Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_027_O09
(404 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q13114|TRAF3_HUMAN TNF receptor-associated factor 3 (CD4... 136 1e-32
sp|Q60803|TRAF3_MOUSE TNF receptor-associated factor 3 (CD4... 136 1e-32
sp|P70191|TRAF5_MOUSE TNF receptor-associated factor 5 134 7e-32
sp|O00463|TRAF5_HUMAN TNF receptor-associated factor 5 (RIN... 130 1e-30
sp|Q13077|TRAF1_HUMAN TNF receptor-associated factor 1 (Eps... 127 1e-29
sp|P39428|TRAF1_MOUSE TNF receptor-associated factor 1 126 2e-29
sp|Q12933|TRAF2_HUMAN TNF receptor-associated factor 2 (Tum... 125 2e-29
sp|P39429|TRAF2_MOUSE TNF receptor-associated factor 2 124 5e-29
sp|Q9BUZ4|TRAF4_HUMAN TNF receptor-associated factor 4 (Cys... 92 3e-19
sp|Q61382|TRAF4_MOUSE TNF receptor-associated factor 4 (Cys... 88 7e-18
>sp|Q13114|TRAF3_HUMAN TNF receptor-associated factor 3 (CD40 receptor associated factor
1) (CRAF1) (CD40 binding protein) (CD40BP) (LMP1
associated protein) (LAP1) (CAP-1)
Length = 568
Score = 136 bits (343), Expect = 1e-32
Identities = 65/123 (52%), Positives = 87/123 (70%), Gaps = 1/123 (0%)
Frame = -2
Query: 400 ISVTSDYFYTKEFGYKMSMKIYPAGDGVGKGTHLSVFFTLMKGEYDDLLQWPFKNKVTLT 221
+S+ S FYT FGYKM ++Y GDG+GKGTHLS+FF +M+GEYD LL WPFK KVTL
Sbjct: 438 LSLYSQPFYTGYFGYKMCARVYLNGDGMGKGTHLSLFFVIMRGEYDALLPWPFKQKVTLM 497
Query: 220 ILDQKNKTNDHSDTFKPDVRSTCYQQPTDEYNIASGSPKFITFSQLED-LYLKNDVIFLK 44
++DQ + D FKPD S+ +++PT E NIASG P F+ + LE+ Y+K+D IF+K
Sbjct: 498 LMDQGSSRRHLGDAFKPDPNSSSFKKPTGEMNIASGCPVFVAQTVLENGTYIKDDTIFIK 557
Query: 43 IAV 35
+ V
Sbjct: 558 VIV 560
>sp|Q60803|TRAF3_MOUSE TNF receptor-associated factor 3 (CD40 receptor associated factor
1) (CRAF1) (TRAFAMN)
Length = 567
Score = 136 bits (343), Expect = 1e-32
Identities = 65/123 (52%), Positives = 87/123 (70%), Gaps = 1/123 (0%)
Frame = -2
Query: 400 ISVTSDYFYTKEFGYKMSMKIYPAGDGVGKGTHLSVFFTLMKGEYDDLLQWPFKNKVTLT 221
+S+ S FYT FGYKM ++Y GDG+GKGTHLS+FF +M+GEYD LL WPFK KVTL
Sbjct: 437 LSLYSQPFYTGYFGYKMCARVYLNGDGMGKGTHLSLFFVIMRGEYDALLPWPFKQKVTLM 496
Query: 220 ILDQKNKTNDHSDTFKPDVRSTCYQQPTDEYNIASGSPKFITFSQLED-LYLKNDVIFLK 44
++DQ + D FKPD S+ +++PT E NIASG P F+ + LE+ Y+K+D IF+K
Sbjct: 497 LMDQGSSRRHLGDAFKPDPNSSSFKKPTGEMNIASGCPVFVAQTVLENGTYIKDDTIFIK 556
Query: 43 IAV 35
+ V
Sbjct: 557 VIV 559
>sp|P70191|TRAF5_MOUSE TNF receptor-associated factor 5
Length = 558
Score = 134 bits (337), Expect = 7e-32
Identities = 63/125 (50%), Positives = 88/125 (70%), Gaps = 3/125 (2%)
Frame = -2
Query: 400 ISVTSDYFYTKEFGYKMSMKIYPAGDGVGKGTHLSVFFTLMKGEYDDLLQWPFKNKVTLT 221
+SV S FYT GY++ + Y GDG GKGTHLS++F +M+GE+D LLQWPF+ +VTL
Sbjct: 426 VSVFSQPFYTSRCGYRLCARAYLNGDGSGKGTHLSLYFVVMRGEFDSLLQWPFRQRVTLM 485
Query: 220 ILDQKNKTNDHSDTFKPDVRSTCYQQPTDEYNIASGSPKFITFSQLE---DLYLKNDVIF 50
+LDQ K N +TFK D S+ +++P E NIASG P+F++ S LE + Y+K+D +F
Sbjct: 486 LLDQSGKKNHIVETFKADPNSSSFKRPDGEMNIASGCPRFVSHSTLENSKNTYIKDDTLF 545
Query: 49 LKIAV 35
LK+AV
Sbjct: 546 LKVAV 550
>sp|O00463|TRAF5_HUMAN TNF receptor-associated factor 5 (RING finger protein 84)
Length = 557
Score = 130 bits (326), Expect = 1e-30
Identities = 61/125 (48%), Positives = 88/125 (70%), Gaps = 3/125 (2%)
Frame = -2
Query: 400 ISVTSDYFYTKEFGYKMSMKIYPAGDGVGKGTHLSVFFTLMKGEYDDLLQWPFKNKVTLT 221
+S+ S FYT GY++ + Y GDG G+G+HLS++F +M+GE+D LLQWPF+ +VTL
Sbjct: 426 VSIFSQSFYTSRCGYRLCARAYLNGDGSGRGSHLSLYFVVMRGEFDSLLQWPFRQRVTLM 485
Query: 220 ILDQKNKTNDHSDTFKPDVRSTCYQQPTDEYNIASGSPKFITFSQLE---DLYLKNDVIF 50
+LDQ K N +TFKPD S+ +++P E NIASG P+F+ S LE + Y+K+D +F
Sbjct: 486 LLDQSGKKN-IMETFKPDPNSSSFKRPDGEMNIASGCPRFVAHSVLENAKNAYIKDDTLF 544
Query: 49 LKIAV 35
LK+AV
Sbjct: 545 LKVAV 549
>sp|Q13077|TRAF1_HUMAN TNF receptor-associated factor 1 (Epstein-Barr virus-induced
protein 6)
Length = 416
Score = 127 bits (318), Expect = 1e-29
Identities = 61/126 (48%), Positives = 87/126 (69%), Gaps = 4/126 (3%)
Frame = -2
Query: 400 ISVTSDYFYTKEFGYKMSMKIYPAGDGVGKGTHLSVFFTLMKGEYDDLLQWPFKNKVTLT 221
+S+ S FYT ++GYK+ +++Y GDG GK THLS+F +M+GEYD LL WPF+NKVT
Sbjct: 289 VSLFSPAFYTAKYGYKLCLRLYLNGDGTGKRTHLSLFIVIMRGEYDALLPWPFRNKVTFM 348
Query: 220 ILDQKNKTNDHS-DTFKPDVRSTCYQQPTDEYNIASGSPKFITFSQLED---LYLKNDVI 53
+LDQ N+ +H+ D F+PD+ S +Q+P E N+ASG P F S+L+ Y+K+D +
Sbjct: 349 LLDQNNR--EHAIDAFRPDLSSASFQRPQSETNVASGCPLFFPLSKLQSPKHAYVKDDTM 406
Query: 52 FLKIAV 35
FLK V
Sbjct: 407 FLKCIV 412
>sp|P39428|TRAF1_MOUSE TNF receptor-associated factor 1
Length = 409
Score = 126 bits (316), Expect = 2e-29
Identities = 61/126 (48%), Positives = 87/126 (69%), Gaps = 4/126 (3%)
Frame = -2
Query: 400 ISVTSDYFYTKEFGYKMSMKIYPAGDGVGKGTHLSVFFTLMKGEYDDLLQWPFKNKVTLT 221
+S+ S FYT ++GYK+ +++Y GDG GK THLS+F +M+GEYD LL WPF+NKVT
Sbjct: 282 VSLFSPAFYTAKYGYKLCLRLYLNGDGSGKKTHLSLFIVIMRGEYDALLPWPFRNKVTFM 341
Query: 220 ILDQKNKTNDHS-DTFKPDVRSTCYQQPTDEYNIASGSPKFITFSQLED---LYLKNDVI 53
+LDQ N+ +H+ D F+PD+ S +Q+P E N+ASG P F S+L+ Y+K+D +
Sbjct: 342 LLDQNNR--EHAIDAFRPDLSSASFQRPQSETNVASGCPLFFPLSKLQSPKHAYVKDDTM 399
Query: 52 FLKIAV 35
FLK V
Sbjct: 400 FLKCIV 405
>sp|Q12933|TRAF2_HUMAN TNF receptor-associated factor 2 (Tumor necrosis factor type 2
receptor-associated protein 3)
Length = 501
Score = 125 bits (315), Expect = 2e-29
Identities = 61/123 (49%), Positives = 86/123 (69%), Gaps = 2/123 (1%)
Frame = -2
Query: 397 SVTSDYFYTKEFGYKMSMKIYPAGDGVGKGTHLSVFFTLMKGEYDDLLQWPFKNKVTLTI 218
++ S FYT +GYKM ++IY GDG G+GTHLS+FF +MKG D LL+WPF KVTL +
Sbjct: 375 AIFSPAFYTSRYGYKMCLRIYLNGDGTGRGTHLSLFFVVMKGPNDALLRWPFNQKVTLML 434
Query: 217 LDQKNKTNDHSDTFKPDVRSTCYQQPTDEYNIASGSPKFITFSQLE--DLYLKNDVIFLK 44
LDQ N+ + D F+PDV S+ +Q+P ++ NIASG P F S++E + Y+++D IF+K
Sbjct: 435 LDQNNREH-VIDAFRPDVTSSSFQRPVNDMNIASGCPLFCPVSKMEAKNSYVRDDAIFIK 493
Query: 43 IAV 35
V
Sbjct: 494 AIV 496
>sp|P39429|TRAF2_MOUSE TNF receptor-associated factor 2
Length = 501
Score = 124 bits (312), Expect = 5e-29
Identities = 60/123 (48%), Positives = 84/123 (68%), Gaps = 2/123 (1%)
Frame = -2
Query: 397 SVTSDYFYTKEFGYKMSMKIYPAGDGVGKGTHLSVFFTLMKGEYDDLLQWPFKNKVTLTI 218
++ S FYT +GYKM +++Y GDG G+GTHLS+FF +MKG D LLQWPF KVTL +
Sbjct: 375 AIFSPAFYTSRYGYKMCLRVYLNGDGTGRGTHLSLFFVVMKGPNDALLQWPFNQKVTLML 434
Query: 217 LDQKNKTNDHSDTFKPDVRSTCYQQPTDEYNIASGSPKFITFSQLE--DLYLKNDVIFLK 44
LD N+ + D F+PDV S+ +Q+P + NIASG P F S++E + Y+++D IF+K
Sbjct: 435 LDHNNREH-VIDAFRPDVTSSSFQRPVSDMNIASGCPLFCPVSKMEAKNSYVRDDAIFIK 493
Query: 43 IAV 35
V
Sbjct: 494 AIV 496
>sp|Q9BUZ4|TRAF4_HUMAN TNF receptor-associated factor 4 (Cysteine-rich domain associated
with RING and Traf domains protein 1) (Malignant 62)
(RING finger protein 83)
Length = 470
Score = 92.4 bits (228), Expect = 3e-19
Identities = 46/129 (35%), Positives = 78/129 (60%), Gaps = 11/129 (8%)
Frame = -2
Query: 388 SDYFYTKEFGYKMSMKIYPAGDGVGKGTHLSVFFTLMKGEYDDLLQWPFKNKVTLTILDQ 209
S FYT ++GYK+ + + G+G G+GTHLS++ ++ G +D+LL+WPF +VT ++LDQ
Sbjct: 334 SPAFYTHKYGYKLQVSAFLNGNGSGEGTHLSLYIRVLPGAFDNLLEWPFARRVTFSLLDQ 393
Query: 208 KN----KTNDHSDTFKPDVRSTCYQQP------TDEYNIASGSPKFITFSQLEDL-YLKN 62
+ K ++TF PD +Q+P DE ++ G PKFI+ + Y+++
Sbjct: 394 SDPGLAKPQHVTETFHPDPNWKNFQKPGTWRGSLDESSLGFGYPKFISHQDIRKRNYVRD 453
Query: 61 DVIFLKIAV 35
D +F++ AV
Sbjct: 454 DAVFIRAAV 462
>sp|Q61382|TRAF4_MOUSE TNF receptor-associated factor 4 (Cysteine-rich motif associated to
RING and Traf domains protein 1)
Length = 470
Score = 87.8 bits (216), Expect = 7e-18
Identities = 44/129 (34%), Positives = 76/129 (58%), Gaps = 11/129 (8%)
Frame = -2
Query: 388 SDYFYTKEFGYKMSMKIYPAGDGVGKGTHLSVFFTLMKGEYDDLLQWPFKNKVTLTILDQ 209
S FYT ++GYK+ + G+G G+GTHLS++ ++ G +D+LL+WP +VT ++LDQ
Sbjct: 334 SPAFYTHKYGYKLQVSASLNGNGSGEGTHLSIYIRVLPGAFDNLLEWPLARRVTFSLLDQ 393
Query: 208 KN----KTNDHSDTFKPDVRSTCYQQP------TDEYNIASGSPKFITFSQLEDL-YLKN 62
+ K ++TF PD +Q+P DE ++ G PKFI+ + Y+++
Sbjct: 394 SDPGLAKPQHVTETFHPDPNWKNFQKPGTWRGSLDESSLGFGYPKFISHQDIRKRNYVRD 453
Query: 61 DVIFLKIAV 35
D +F++ +V
Sbjct: 454 DAVFIRASV 462
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 50,652,387
Number of Sequences: 369166
Number of extensions: 1040010
Number of successful extensions: 2198
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 2159
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 2187
length of database: 68,354,980
effective HSP length: 98
effective length of database: 50,250,950
effective search space used: 1809034200
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)