Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_027_O08
(666 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|O60911|CATL2_HUMAN Cathepsin L2 precursor (Cathepsin V) ... 172 5e-43
sp|Q9GL24|CATL_CANFA Cathepsin L precursor [Contains: Cathe... 172 7e-43
sp|Q24940|CATLP_FASHE Cathepsin L-like proteinase precursor 170 4e-42
sp|P07711|CATL_HUMAN Cathepsin L precursor (Major excreted ... 169 8e-42
sp|Q28944|CATL_PIG Cathepsin L precursor [Contains: Catheps... 166 7e-41
sp|P25975|CATL_BOVIN Cathepsin L precursor [Contains: Cathe... 164 3e-40
sp|P06797|CATL_MOUSE Cathepsin L precursor (Major excreted ... 160 3e-39
sp|P43236|CATK_RABIT Cathepsin K precursor (OC-2 protein) 159 8e-39
sp|O35186|CATK_RAT Cathepsin K precursor 158 1e-38
sp|P07154|CATL_RAT Cathepsin L precursor (Major excreted pr... 157 2e-38
>sp|O60911|CATL2_HUMAN Cathepsin L2 precursor (Cathepsin V) (Cathepsin U)
Length = 334
Score = 172 bits (437), Expect = 5e-43
Identities = 86/177 (48%), Positives = 116/177 (65%)
Frame = +2
Query: 8 LILSLVVVAITAVPQKFSVNSELNEEWETYKTTFGRKYDELTDITRRLIWEQNLKYIQKH 187
L+L+ + I + KF N L+ +W +K T R Y + RR +WE+N+K I+ H
Sbjct: 5 LVLAAFCLGIASAVPKFDQN--LDTKWYQWKATHRRLYGANEEGWRRAVWEKNMKMIELH 62
Query: 188 NLEYDLGKHTYSLGLNQFADMTNEEFKAKYLGIMKTKPTLEGSTYMAPENIGVLPASVDW 367
N EY GKH +++ +N F DMTNEEF+ + +G + + +G + P + LP SVDW
Sbjct: 63 NGEYSQGKHGFTMAMNAFGDMTNEEFR-QMMGCFRNQKFRKGKVFREPLFLD-LPKSVDW 120
Query: 368 RQKGYVTPVKNQQQCGSCWSFSATGSLEGQYFRKNNRLISFSEQQLVDCSGAYGNYG 538
R+KGYVTPVKNQ+QCGSCW+FSATG+LEGQ FRK +L+S SEQ LVDCS GN G
Sbjct: 121 RKKGYVTPVKNQKQCGSCWAFSATGALEGQMFRKTGKLVSLSEQNLVDCSRPQGNQG 177
Score = 43.5 bits (101), Expect = 5e-04
Identities = 18/36 (50%), Positives = 23/36 (63%), Gaps = 1/36 (2%)
Frame = +3
Query: 537 GCGGGLMDNAFRYIKDQ-GIESEGDYPYTGTDGTCK 641
GC GG M AF+Y+K+ G++SE YPY D CK
Sbjct: 177 GCNGGFMARAFQYVKENGGLDSEESYPYVAVDEICK 212
>sp|Q9GL24|CATL_CANFA Cathepsin L precursor [Contains: Cathepsin L heavy chain; Cathepsin
L light chain]
Length = 333
Score = 172 bits (436), Expect = 7e-43
Identities = 87/177 (49%), Positives = 112/177 (63%)
Frame = +2
Query: 8 LILSLVVVAITAVPQKFSVNSELNEEWETYKTTFGRKYDELTDITRRLIWEQNLKYIQKH 187
L L+ + + I + KF + LN +W +K T R Y + RR +WE+N+K I+ H
Sbjct: 5 LFLTALCLGIASAAPKF--DQSLNAQWYQWKATHRRLYGMNEEGWRRAVWEKNMKMIELH 62
Query: 188 NLEYDLGKHTYSLGLNQFADMTNEEFKAKYLGIMKTKPTLEGSTYMAPENIGVLPASVDW 367
N EY GKH +++ +N F DMTNEEF+ G K +G + P +P SVDW
Sbjct: 63 NREYSQGKHGFTMAMNAFGDMTNEEFRQVMNGFQNQKHK-KGKMFQEPL-FAEIPKSVDW 120
Query: 368 RQKGYVTPVKNQQQCGSCWSFSATGSLEGQYFRKNNRLISFSEQQLVDCSGAYGNYG 538
R+KGYVTPVKNQ QCGSCW+FSATG+LEGQ FRK +L+S SEQ LVDCS A GN G
Sbjct: 121 REKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGKLVSLSEQNLVDCSRAQGNEG 177
Score = 52.0 bits (123), Expect = 1e-06
Identities = 25/39 (64%), Positives = 28/39 (71%), Gaps = 2/39 (5%)
Frame = +3
Query: 537 GCGGGLMDNAFRYIKDQ-GIESEGDYPYTGTD-GTCKKK 647
GC GGLMDNAFRY+KD G++SE YPY G D TC K
Sbjct: 177 GCNGGLMDNAFRYVKDNGGLDSEESYPYLGRDTETCNYK 215
>sp|Q24940|CATLP_FASHE Cathepsin L-like proteinase precursor
Length = 326
Score = 170 bits (430), Expect = 4e-42
Identities = 84/175 (48%), Positives = 111/175 (63%)
Frame = +2
Query: 14 LSLVVVAITAVPQKFSVNSELNEEWETYKTTFGRKYDELTDITRRLIWEQNLKYIQKHNL 193
+ L ++A+ V V ++ W +K + ++Y+ D RR IWE+N+K+IQ+HNL
Sbjct: 1 MRLFILAVLTV----GVLGSNDDLWHQWKRMYNKEYNGADDQHRRNIWEKNVKHIQEHNL 56
Query: 194 EYDLGKHTYSLGLNQFADMTNEEFKAKYLGIMKTKPTLEGSTYMAPENIGVLPASVDWRQ 373
+DLG TY+LGLNQF DMT EEFKAKYL M + N +P +DWR+
Sbjct: 57 RHDLGLVTYTLGLNQFTDMTFEEFKAKYLTEMSRASDILSHGVPYEANNRAVPDKIDWRE 116
Query: 374 KGYVTPVKNQQQCGSCWSFSATGSLEGQYFRKNNRLISFSEQQLVDCSGAYGNYG 538
GYVT VK+Q CGSCW+FS TG++EGQY + ISFSEQQLVDCSG +GN G
Sbjct: 117 SGYVTEVKDQGNCGSCWAFSTTGTMEGQYMKNERTSISFSEQQLVDCSGPWGNNG 171
Score = 53.1 bits (126), Expect = 6e-07
Identities = 19/35 (54%), Positives = 27/35 (77%)
Frame = +3
Query: 537 GCGGGLMDNAFRYIKDQGIESEGDYPYTGTDGTCK 641
GC GGLM+NA++Y+K G+E+E YPYT +G C+
Sbjct: 171 GCSGGLMENAYQYLKQFGLETESSYPYTAVEGQCR 205
>sp|P07711|CATL_HUMAN Cathepsin L precursor (Major excreted protein) (MEP) [Contains:
Cathepsin L heavy chain; Cathepsin L light chain]
Length = 333
Score = 169 bits (427), Expect = 8e-42
Identities = 87/177 (49%), Positives = 110/177 (62%)
Frame = +2
Query: 8 LILSLVVVAITAVPQKFSVNSELNEEWETYKTTFGRKYDELTDITRRLIWEQNLKYIQKH 187
LIL+ + I + F + L +W +K R Y + RR +WE+N+K I+ H
Sbjct: 5 LILAAFCLGIASATLTF--DHSLEAQWTKWKAMHNRLYGMNEEGWRRAVWEKNMKMIELH 62
Query: 188 NLEYDLGKHTYSLGLNQFADMTNEEFKAKYLGIMKTKPTLEGSTYMAPENIGVLPASVDW 367
N EY GKH++++ +N F DMT+EEF+ G KP +G + P P SVDW
Sbjct: 63 NQEYREGKHSFTMAMNAFGDMTSEEFRQVMNGFQNRKPR-KGKVFQEPLFYEA-PRSVDW 120
Query: 368 RQKGYVTPVKNQQQCGSCWSFSATGSLEGQYFRKNNRLISFSEQQLVDCSGAYGNYG 538
R+KGYVTPVKNQ QCGSCW+FSATG+LEGQ FRK RLIS SEQ LVDCSG GN G
Sbjct: 121 REKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGRLISLSEQNLVDCSGPQGNEG 177
Score = 48.1 bits (113), Expect = 2e-05
Identities = 20/36 (55%), Positives = 27/36 (75%), Gaps = 1/36 (2%)
Frame = +3
Query: 537 GCGGGLMDNAFRYIKDQ-GIESEGDYPYTGTDGTCK 641
GC GGLMD AF+Y++D G++SE YPY T+ +CK
Sbjct: 177 GCNGGLMDYAFQYVQDNGGLDSEESYPYEATEESCK 212
>sp|Q28944|CATL_PIG Cathepsin L precursor [Contains: Cathepsin L heavy chain; Cathepsin
L light chain]
Length = 334
Score = 166 bits (419), Expect = 7e-41
Identities = 86/177 (48%), Positives = 110/177 (62%)
Frame = +2
Query: 8 LILSLVVVAITAVPQKFSVNSELNEEWETYKTTFGRKYDELTDITRRLIWEQNLKYIQKH 187
L L+ + + I + K N L+ +W +K T GR Y + RR +WE+N+K I+ H
Sbjct: 5 LFLTALCLGIASAAPKLDQN--LDADWYKWKATHGRLYGMNEEGWRRAVWEKNMKMIELH 62
Query: 188 NLEYDLGKHTYSLGLNQFADMTNEEFKAKYLGIMKTKPTLEGSTYMAPENIGVLPASVDW 367
N EY GKH +S+ +N F DMTNEEF+ G K +G + + V P SVDW
Sbjct: 63 NQEYSQGKHGFSMAMNAFGDMTNEEFRQVMNGFQNQKHK-KGKVFHESLVLEV-PKSVDW 120
Query: 368 RQKGYVTPVKNQQQCGSCWSFSATGSLEGQYFRKNNRLISFSEQQLVDCSGAYGNYG 538
R+KGYVT VKNQ QCGSCW+FSATG+LEGQ FRK +L+S SEQ LVDCS GN G
Sbjct: 121 REKGYVTAVKNQGQCGSCWAFSATGALEGQMFRKTGKLVSLSEQNLVDCSRPQGNQG 177
Score = 46.6 bits (109), Expect = 6e-05
Identities = 19/32 (59%), Positives = 25/32 (78%), Gaps = 1/32 (3%)
Frame = +3
Query: 537 GCGGGLMDNAFRYIKDQ-GIESEGDYPYTGTD 629
GC GGLMDNAF+Y+KD G+++E YPY G +
Sbjct: 177 GCNGGLMDNAFQYVKDNGGLDTEESYPYLGRE 208
>sp|P25975|CATL_BOVIN Cathepsin L precursor [Contains: Cathepsin L heavy chain; Cathepsin
L light chain]
Length = 334
Score = 164 bits (414), Expect = 3e-40
Identities = 84/175 (48%), Positives = 107/175 (61%)
Frame = +2
Query: 14 LSLVVVAITAVPQKFSVNSELNEEWETYKTTFGRKYDELTDITRRLIWEQNLKYIQKHNL 193
L+++ + + + K N L+ W +K T R Y + RR +WE+N K I HN
Sbjct: 7 LTVLCLGVASAAPKLDPN--LDAHWHQWKATHRRLYGMNEEEWRRAVWEKNKKIIDLHNQ 64
Query: 194 EYDLGKHTYSLGLNQFADMTNEEFKAKYLGIMKTKPTLEGSTYMAPENIGVLPASVDWRQ 373
EY GKH + + +N F DMTNEEF+ G K +G + P + V P SVDW +
Sbjct: 65 EYSEGKHAFRMAMNAFGDMTNEEFRQVMNGFQNQKHK-KGKLFHEPLLVDV-PKSVDWTK 122
Query: 374 KGYVTPVKNQQQCGSCWSFSATGSLEGQYFRKNNRLISFSEQQLVDCSGAYGNYG 538
KGYVTPVKNQ QCGSCW+FSATG+LEGQ FRK +L+S SEQ LVDCS A GN G
Sbjct: 123 KGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGKLVSLSEQNLVDCSRAQGNQG 177
Score = 50.1 bits (118), Expect = 5e-06
Identities = 24/39 (61%), Positives = 28/39 (71%), Gaps = 2/39 (5%)
Frame = +3
Query: 537 GCGGGLMDNAFRYIKDQ-GIESEGDYPYTGTD-GTCKKK 647
GC GGLMDNAF+YIKD G++SE YPY TD +C K
Sbjct: 177 GCNGGLMDNAFQYIKDNGGLDSEESYPYLATDTNSCNYK 215
>sp|P06797|CATL_MOUSE Cathepsin L precursor (Major excreted protein) (MEP) (p39 cysteine
proteinase) [Contains: Cathepsin L heavy chain;
Cathepsin L light chain]
Length = 334
Score = 160 bits (405), Expect = 3e-39
Identities = 84/178 (47%), Positives = 111/178 (62%)
Frame = +2
Query: 5 ILILSLVVVAITAVPQKFSVNSELNEEWETYKTTFGRKYDELTDITRRLIWEQNLKYIQK 184
+L+L+++ + KF + + EW +K+T R Y + RR IWE+N++ IQ
Sbjct: 4 LLLLAVLCLGTALATPKF--DQTFSAEWHQWKSTHRRLYGTNEEEWRRAIWEKNMRMIQL 61
Query: 185 HNLEYDLGKHTYSLGLNQFADMTNEEFKAKYLGIMKTKPTLEGSTYMAPENIGVLPASVD 364
HN EY G+H +S+ +N F DMTNEEF+ G K +G + P + + P SVD
Sbjct: 62 HNGEYSNGQHGFSMEMNAFGDMTNEEFRQVVNGYRHQKHK-KGRLFQEPLMLKI-PKSVD 119
Query: 365 WRQKGYVTPVKNQQQCGSCWSFSATGSLEGQYFRKNNRLISFSEQQLVDCSGAYGNYG 538
WR+KG VTPVKNQ QCGSCW+FSA+G LEGQ F K +LIS SEQ LVDCS A GN G
Sbjct: 120 WREKGCVTPVKNQGQCGSCWAFSASGCLEGQMFLKTGKLISLSEQNLVDCSHAQGNQG 177
Score = 50.4 bits (119), Expect = 4e-06
Identities = 22/36 (61%), Positives = 27/36 (75%), Gaps = 1/36 (2%)
Frame = +3
Query: 537 GCGGGLMDNAFRYIKDQ-GIESEGDYPYTGTDGTCK 641
GC GGLMD AF+YIK+ G++SE YPY DG+CK
Sbjct: 177 GCNGGLMDFAFQYIKENGGLDSEESYPYEAKDGSCK 212
>sp|P43236|CATK_RABIT Cathepsin K precursor (OC-2 protein)
Length = 329
Score = 159 bits (401), Expect = 8e-39
Identities = 89/196 (45%), Positives = 120/196 (61%), Gaps = 3/196 (1%)
Frame = +2
Query: 11 ILSLVVVAITAVPQKFSVNSELNEEWETYKTTFGRKYDELTD-ITRRLIWEQNLKYIQKH 187
+L L VV+ P++ L+ +WE +K T+ ++Y+ D I+RRLIWE+NLK+I H
Sbjct: 6 VLLLPVVSFALHPEEI-----LDTQWELWKKTYSKQYNSKVDEISRRLIWEKNLKHISIH 60
Query: 188 NLEYDLGKHTYSLGLNQFADMTNEEFKAKYLGIMKTKPTLEGS--TYMAPENIGVLPASV 361
NLE LG HTY L +N DMT+EE K G+ K P+ S T P+ G P S+
Sbjct: 61 NLEASLGVHTYELAMNHLGDMTSEEVVQKMTGL-KVPPSRSHSNDTLYIPDWEGRTPDSI 119
Query: 362 DWRQKGYVTPVKNQQQCGSCWSFSATGSLEGQYFRKNNRLISFSEQQLVDCSGAYGNYGM 541
D+R+KGYVTPVKNQ QCGSCW+FS+ G+LEGQ +K +L++ S Q LVDC NYG
Sbjct: 120 DYRKKGYVTPVKNQGQCGSCWAFSSVGALEGQLKKKTGKLLNLSPQNLVDCVSE--NYGC 177
Query: 542 WWRSYG*RFQIYKRSR 589
FQ +R+R
Sbjct: 178 GGGYMTNAFQYVQRNR 193
Score = 49.3 bits (116), Expect = 9e-06
Identities = 22/44 (50%), Positives = 31/44 (70%), Gaps = 1/44 (2%)
Frame = +3
Query: 510 IVVVLMEIMGCGGGLMDNAFRYI-KDQGIESEGDYPYTGTDGTC 638
+V + E GCGGG M NAF+Y+ +++GI+SE YPY G D +C
Sbjct: 167 LVDCVSENYGCGGGYMTNAFQYVQRNRGIDSEDAYPYVGQDESC 210
>sp|O35186|CATK_RAT Cathepsin K precursor
Length = 329
Score = 158 bits (399), Expect = 1e-38
Identities = 84/177 (47%), Positives = 111/177 (62%), Gaps = 2/177 (1%)
Frame = +2
Query: 14 LSLVVVAITAVPQKFSVNSELNEEWETYKTTFGRKYDELTD-ITRRLIWEQNLKYIQKHN 190
L L VV+ P++ L+ +WE +K T G++Y+ D I+RRLIWE+NLK I HN
Sbjct: 7 LLLPVVSFALSPEE-----TLDTQWELWKKTHGKQYNSKVDEISRRLIWEKNLKKISVHN 61
Query: 191 LEYDLGKHTYSLGLNQFADMTNEEFKAKYLGI-MKTKPTLEGSTYMAPENIGVLPASVDW 367
LE LG HTY L +N DMT+EE K G+ + + T PE G +P S+D+
Sbjct: 62 LEASLGAHTYELAMNHLGDMTSEEVVQKMTGLRVPPSRSFSNDTLYTPEWEGRVPDSIDY 121
Query: 368 RQKGYVTPVKNQQQCGSCWSFSATGSLEGQYFRKNNRLISFSEQQLVDCSGAYGNYG 538
R+KGYVTPVKNQ QCGSCW+FS+ G+LEGQ +K +L++ S Q LVDC NYG
Sbjct: 122 RKKGYVTPVKNQGQCGSCWAFSSAGALEGQLKKKTGKLLALSPQNLVDCVSE--NYG 176
Score = 45.8 bits (107), Expect = 1e-04
Identities = 21/44 (47%), Positives = 28/44 (63%), Gaps = 1/44 (2%)
Frame = +3
Query: 510 IVVVLMEIMGCGGGLMDNAFRYIKDQ-GIESEGDYPYTGTDGTC 638
+V + E GCGGG M AF+Y++ GI+SE YPY G D +C
Sbjct: 167 LVDCVSENYGCGGGYMTTAFQYVQQNGGIDSEDAYPYVGQDESC 210
>sp|P07154|CATL_RAT Cathepsin L precursor (Major excreted protein) (MEP) (Cyclic
protein 2) (CP-2) [Contains: Cathepsin L heavy chain;
Cathepsin L light chain]
Length = 334
Score = 157 bits (397), Expect = 2e-38
Identities = 81/178 (45%), Positives = 110/178 (61%)
Frame = +2
Query: 5 ILILSLVVVAITAVPQKFSVNSELNEEWETYKTTFGRKYDELTDITRRLIWEQNLKYIQK 184
+L+L+++ + KF + N +W +K+T R Y + RR +WE+N++ IQ
Sbjct: 4 LLLLAVLCLGTALATPKF--DQTFNAQWHQWKSTHRRLYGTNEEEWRRAVWEKNMRMIQL 61
Query: 185 HNLEYDLGKHTYSLGLNQFADMTNEEFKAKYLGIMKTKPTLEGSTYMAPENIGVLPASVD 364
HN EY GKH +++ +N F DMTNEEF+ G K +G + P + + P +VD
Sbjct: 62 HNGEYSNGKHGFTMEMNAFGDMTNEEFRQIVNGYRHQKHK-KGRLFQEPLMLQI-PKTVD 119
Query: 365 WRQKGYVTPVKNQQQCGSCWSFSATGSLEGQYFRKNNRLISFSEQQLVDCSGAYGNYG 538
WR+KG VTPVKNQ QCGSCW+FSA+G LEGQ F K +LIS SEQ LVDCS GN G
Sbjct: 120 WREKGCVTPVKNQGQCGSCWAFSASGCLEGQMFLKTGKLISLSEQNLVDCSHDQGNQG 177
Score = 50.4 bits (119), Expect = 4e-06
Identities = 22/36 (61%), Positives = 27/36 (75%), Gaps = 1/36 (2%)
Frame = +3
Query: 537 GCGGGLMDNAFRYIKDQ-GIESEGDYPYTGTDGTCK 641
GC GGLMD AF+YIK+ G++SE YPY DG+CK
Sbjct: 177 GCNGGLMDFAFQYIKENGGLDSEESYPYEAKDGSCK 212
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 74,959,011
Number of Sequences: 369166
Number of extensions: 1530101
Number of successful extensions: 4872
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 4345
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 4655
length of database: 68,354,980
effective HSP length: 106
effective length of database: 48,773,070
effective search space used: 5608903050
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)