Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_027_O03
(474 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P26928|HGFL_MOUSE Hepatocyte growth factor-like protein ... 82 6e-16
sp|O18783|PLMN_MACEU Plasminogen precursor [Contains: Plasm... 75 8e-14
sp|P12545|PLMN_MACMU Plasminogen precursor [Contains: Plasm... 75 1e-13
sp|Q01177|PLMN_RAT Plasminogen precursor [Contains: Plasmin... 74 2e-13
sp|P06867|PLMN_PIG Plasminogen precursor [Contains: Plasmin... 73 4e-13
sp|P00747|PLMN_HUMAN Plasminogen precursor [Contains: Plasm... 72 6e-13
sp|P26927|HGFL_HUMAN Hepatocyte growth factor-like protein ... 72 6e-13
sp|P06868|PLMN_BOVIN Plasminogen precursor [Contains: Plasm... 72 8e-13
sp|P14210|HGF_HUMAN Hepatocyte growth factor precursor (Sca... 71 1e-12
sp|P20918|PLMN_MOUSE Plasminogen precursor [Contains: Plasm... 71 1e-12
>sp|P26928|HGFL_MOUSE Hepatocyte growth factor-like protein precursor (Macrophage
stimulatory protein) (MSP) [Contains: Hepatocyte growth
factor-like protein alpha chain; Hepatocyte growth
factor-like protein beta chain]
Length = 716
Score = 82.0 bits (201), Expect = 6e-16
Identities = 37/100 (37%), Positives = 58/100 (58%)
Frame = +2
Query: 41 CHLDLREDDICILESEIDYSGKLNKTIGGHICQKWSSQHPHKHNFISDWQFSERDILKAE 220
C + + +C+L + DY G+++ T G CQ+W QHPH H F + +F ++D+ +
Sbjct: 181 CGIKTCREAVCVLCNGEDYRGEVDVTESGRECQRWDLQHPHSHPFQPE-KFLDKDL--KD 237
Query: 221 NFCRNPLLEKMGFHQAKDRLWCYTSNPNVRFDYCDPPLCG 340
N+CRNP +R WCYT++PNV ++CD P CG
Sbjct: 238 NYCRNP--------DGSERPWCYTTDPNVEREFCDLPSCG 269
Score = 65.1 bits (157), Expect = 8e-11
Identities = 36/101 (35%), Positives = 55/101 (54%), Gaps = 2/101 (1%)
Frame = +2
Query: 41 CHLDLREDDI--CILESEIDYSGKLNKTIGGHICQKWSSQHPHKHNFISDWQFSERDILK 214
CHL ++D + CI+++ + Y G + +T GG CQ WS + P+ H + + ++ L+
Sbjct: 98 CHLFQKKDYVRTCIMDNGVSYRGTVARTAGGLPCQAWSRRFPNDHKYTP----TPKNGLE 153
Query: 215 AENFCRNPLLEKMGFHQAKDRLWCYTSNPNVRFDYCDPPLC 337
ENFCRNP + G WCYT+N +VRF C C
Sbjct: 154 -ENFCRNPDGDPRG-------PWCYTTNRSVRFQSCGIKTC 186
Score = 63.5 bits (153), Expect = 2e-10
Identities = 29/77 (37%), Positives = 43/77 (55%)
Frame = +2
Query: 92 DYSGKLNKTIGGHICQKWSSQHPHKHNFISDWQFSERDILKAENFCRNPLLEKMGFHQAK 271
DY G N T G CQ+W +Q PH+H F+ + +++ +D+ ENFCRNP
Sbjct: 299 DYRGTTNTTSAGVPCQRWDAQSPHQHRFVPE-KYACKDL--RENFCRNP--------DGS 347
Query: 272 DRLWCYTSNPNVRFDYC 322
+ WC+TS P +R +C
Sbjct: 348 EAPWCFTSRPGLRMAFC 364
Score = 57.4 bits (137), Expect = 2e-08
Identities = 34/89 (38%), Positives = 41/89 (46%)
Frame = +2
Query: 71 CILESEIDYSGKLNKTIGGHICQKWSSQHPHKHNFISDWQFSERDILKAENFCRNPLLEK 250
C S Y G ++KT G CQ WSS+ PHK F S NFCRNP +
Sbjct: 379 CYHGSGEQYRGSVSKTRKGVQCQHWSSETPHKPQFTPT---SAPQAGLEANFCRNPDGDS 435
Query: 251 MGFHQAKDRLWCYTSNPNVRFDYCDPPLC 337
G WCYT +P++ FDYC C
Sbjct: 436 HG-------PWCYTLDPDILFDYCALQRC 457
>sp|O18783|PLMN_MACEU Plasminogen precursor [Contains: Plasmin heavy chain A; Activation
peptide; Plasmin heavy chain A, short form; Plasmin
light chain B]
Length = 806
Score = 75.1 bits (183), Expect = 8e-14
Identities = 38/98 (38%), Positives = 52/98 (53%)
Frame = +2
Query: 71 CILESEIDYSGKLNKTIGGHICQKWSSQHPHKHNFISDWQFSERDILKAENFCRNPLLEK 250
C+ +Y GK+ T GH CQ+W+ Q PHKHN + F R + EN+CRNP
Sbjct: 275 CLKGRGENYRGKIAVTKSGHTCQRWNKQTPHKHNRTPE-NFPCRGL--DENYCRNP---- 327
Query: 251 MGFHQAKDRLWCYTSNPNVRFDYCDPPLCGNQYAYNDK 364
+ WCYT+NP+VR +YC P CG + D+
Sbjct: 328 ----DGELEPWCYTTNPDVRQEYCAIPSCGTSSPHTDR 361
Score = 74.7 bits (182), Expect = 1e-13
Identities = 35/89 (39%), Positives = 48/89 (53%)
Frame = +2
Query: 71 CILESEIDYSGKLNKTIGGHICQKWSSQHPHKHNFISDWQFSERDILKAENFCRNPLLEK 250
C+ S DY GK + T+ G +CQ W++Q PH+H + + + EN+CRNP +
Sbjct: 476 CMYGSGKDYRGKRSTTVTGTLCQAWTAQEPHRHTIFTPDTYPRAGL--EENYCRNPDGDP 533
Query: 251 MGFHQAKDRLWCYTSNPNVRFDYCDPPLC 337
G WCYT+NP FDYCD P C
Sbjct: 534 NG-------PWCYTTNPKKLFDYCDIPQC 555
Score = 74.3 bits (181), Expect = 1e-13
Identities = 36/94 (38%), Positives = 53/94 (56%)
Frame = +2
Query: 62 DDICILESEIDYSGKLNKTIGGHICQKWSSQHPHKHNFISDWQFSERDILKAENFCRNPL 241
+D C+ S +Y G ++KT G CQ W SQ PH H +I +F +D+ EN+CRNP
Sbjct: 182 EDECMHCSGENYRGTISKTESGIECQPWDSQEPHSHEYIPS-KFPSKDL--KENYCRNP- 237
Query: 242 LEKMGFHQAKDRLWCYTSNPNVRFDYCDPPLCGN 343
+ R WC+TSNP R+++C+ P C +
Sbjct: 238 -------DGEPRPWCFTSNPEKRWEFCNIPRCSS 264
Score = 67.8 bits (164), Expect = 1e-11
Identities = 37/108 (34%), Positives = 56/108 (51%), Gaps = 11/108 (10%)
Frame = +2
Query: 56 REDDICILESEI-----------DYSGKLNKTIGGHICQKWSSQHPHKHNFISDWQFSER 202
R+ D+ + E I +Y G L+KT G CQKWS PH N+ ++ +
Sbjct: 87 RKRDVVLFEKRIYLSDCKSGNGRNYRGTLSKTKSGITCQKWSDLSPHVPNYAPS-KYPDA 145
Query: 203 DILKAENFCRNPLLEKMGFHQAKDRLWCYTSNPNVRFDYCDPPLCGNQ 346
+ K N+CRNP + G WCYT+NP++R++YCD P C ++
Sbjct: 146 GLEK--NYCRNPDDDVKG-------PWCYTTNPDIRYEYCDVPECEDE 184
Score = 61.6 bits (148), Expect = 9e-10
Identities = 31/82 (37%), Positives = 44/82 (53%)
Frame = +2
Query: 92 DYSGKLNKTIGGHICQKWSSQHPHKHNFISDWQFSERDILKAENFCRNPLLEKMGFHQAK 271
+Y G + TI G CQ WSS PH+H D F D+++ N+CRNP +K
Sbjct: 378 NYRGTTSTTISGKKCQAWSSMTPHQHKKTPD-NFPNADLIR--NYCRNPDGDKSP----- 429
Query: 272 DRLWCYTSNPNVRFDYCDPPLC 337
WCYT +P VR+++C+ C
Sbjct: 430 ---WCYTMDPTVRWEFCNLEKC 448
>sp|P12545|PLMN_MACMU Plasminogen precursor [Contains: Plasmin heavy chain A; Activation
peptide; Plasmin heavy chain A, short form; Plasmin
light chain B]
Length = 810
Score = 74.7 bits (182), Expect = 1e-13
Identities = 36/92 (39%), Positives = 54/92 (58%)
Frame = +2
Query: 62 DDICILESEIDYSGKLNKTIGGHICQKWSSQHPHKHNFISDWQFSERDILKAENFCRNPL 241
+D C+ S +Y GK++KT+ G CQ W SQ PH H +I +F +++ K N+CRNP
Sbjct: 182 EDECMHCSGENYDGKISKTMSGLECQAWDSQSPHAHGYIPS-KFPNKNLKK--NYCRNP- 237
Query: 242 LEKMGFHQAKDRLWCYTSNPNVRFDYCDPPLC 337
+ R WC+T++PN R++ CD P C
Sbjct: 238 -------DGEPRPWCFTTDPNKRWELCDIPRC 262
Score = 68.6 bits (166), Expect = 7e-12
Identities = 36/85 (42%), Positives = 46/85 (54%)
Frame = +2
Query: 92 DYSGKLNKTIGGHICQKWSSQHPHKHNFISDWQFSERDILKAENFCRNPLLEKMGFHQAK 271
+Y G ++KT G CQKWSS PH+ F SE EN+CRNP + G
Sbjct: 110 NYRGTMSKTRTGITCQKWSSTSPHRPTFSPATHPSEG---LEENYCRNPDNDGQG----- 161
Query: 272 DRLWCYTSNPNVRFDYCDPPLCGNQ 346
WCYT++P RFDYCD P C ++
Sbjct: 162 --PWCYTTDPEERFDYCDIPECEDE 184
Score = 66.2 bits (160), Expect = 4e-11
Identities = 34/89 (38%), Positives = 48/89 (53%)
Frame = +2
Query: 71 CILESEIDYSGKLNKTIGGHICQKWSSQHPHKHNFISDWQFSERDILKAENFCRNPLLEK 250
C+ + +Y G + T+ GH C WS+Q PH HN + F +++ EN+CRNP EK
Sbjct: 275 CLKGTGENYRGDVAVTVSGHTCHGWSAQTPHTHNRTPE-NFPCKNL--DENYCRNPDGEK 331
Query: 251 MGFHQAKDRLWCYTSNPNVRFDYCDPPLC 337
WCYT+N VR++YC P C
Sbjct: 332 AP--------WCYTTNSQVRWEYCKIPSC 352
Score = 65.5 bits (158), Expect = 6e-11
Identities = 33/92 (35%), Positives = 46/92 (50%)
Frame = +2
Query: 62 DDICILESEIDYSGKLNKTIGGHICQKWSSQHPHKHNFISDWQFSERDILKAENFCRNPL 241
++ C+ + Y GK T+ G CQ+W++Q PH H + + K N+CRNP
Sbjct: 478 EEDCMFGNGKGYRGKKATTVTGTPCQEWAAQEPHSHRIFTPETNPRAGLEK--NYCRNPD 535
Query: 242 LEKMGFHQAKDRLWCYTSNPNVRFDYCDPPLC 337
+ G WCYT+NP FDYCD P C
Sbjct: 536 GDVGG-------PWCYTTNPRKLFDYCDVPQC 560
Score = 52.0 bits (123), Expect = 7e-07
Identities = 28/81 (34%), Positives = 40/81 (49%)
Frame = +2
Query: 95 YSGKLNKTIGGHICQKWSSQHPHKHNFISDWQFSERDILKAENFCRNPLLEKMGFHQAKD 274
Y G + T G CQ WSS PH H + F + N+CRNP +K
Sbjct: 385 YRGTSSTTTTGKKCQSWSSMTPHWHEKTPE-NFPNAGLTM--NYCRNPDADKGP------ 435
Query: 275 RLWCYTSNPNVRFDYCDPPLC 337
WC+T++P+VR++YC+ C
Sbjct: 436 --WCFTTDPSVRWEYCNLKKC 454
>sp|Q01177|PLMN_RAT Plasminogen precursor [Contains: Plasmin heavy chain A; Activation
peptide; Angiostatin; Plasmin heavy chain A, short form;
Plasmin light chain B]
Length = 812
Score = 73.9 bits (180), Expect = 2e-13
Identities = 37/99 (37%), Positives = 57/99 (57%)
Frame = +2
Query: 41 CHLDLREDDICILESEIDYSGKLNKTIGGHICQKWSSQHPHKHNFISDWQFSERDILKAE 220
C++ E++ C+ S Y GK++KT+ G CQ W SQ PH H +I +F +++
Sbjct: 176 CNIPECEEE-CMYCSGEKYEGKISKTMSGLDCQSWDSQSPHAHGYIPA-KFPSKNL--KM 231
Query: 221 NFCRNPLLEKMGFHQAKDRLWCYTSNPNVRFDYCDPPLC 337
N+CRNP + R WC+T++PN R++YCD P C
Sbjct: 232 NYCRNP--------DGEPRPWCFTTDPNKRWEYCDIPRC 262
Score = 65.9 bits (159), Expect = 5e-11
Identities = 31/91 (34%), Positives = 50/91 (54%)
Frame = +2
Query: 71 CILESEIDYSGKLNKTIGGHICQKWSSQHPHKHNFISDWQFSERDILKAENFCRNPLLEK 250
C+ +Y G ++ T G CQ+WS Q PH+HN + F +++ EN+CRNP
Sbjct: 275 CLKGRGENYRGTVSVTASGKTCQRWSEQTPHRHNRTPE-NFPCKNL--EENYCRNP---- 327
Query: 251 MGFHQAKDRLWCYTSNPNVRFDYCDPPLCGN 343
+ WCYT++ +R++YC+ P CG+
Sbjct: 328 ----DGETAPWCYTTDSQLRWEYCEIPSCGS 354
Score = 65.1 bits (157), Expect = 8e-11
Identities = 34/91 (37%), Positives = 49/91 (53%)
Frame = +2
Query: 71 CILESEIDYSGKLNKTIGGHICQKWSSQHPHKHNFISDWQFSERDILKAENFCRNPLLEK 250
C+ + +Y GK T G CQ+W++Q PH H + Q + R L+ +N+CRNP +
Sbjct: 481 CMYGNGKEYRGKTAVTAAGTPCQEWAAQEPHSHRIFTP-QTNPRAGLE-KNYCRNPDGDV 538
Query: 251 MGFHQAKDRLWCYTSNPNVRFDYCDPPLCGN 343
G WCYT NP +DYC+ PLC +
Sbjct: 539 NG-------PWCYTMNPRKLYDYCNIPLCAS 562
Score = 62.8 bits (151), Expect = 4e-10
Identities = 32/87 (36%), Positives = 45/87 (51%)
Frame = +2
Query: 95 YSGKLNKTIGGHICQKWSSQHPHKHNFISDWQFSERDILKAENFCRNPLLEKMGFHQAKD 274
Y G ++KT G CQKWS PH + SE EN+CRNP ++ G
Sbjct: 111 YRGTMSKTKTGVTCQKWSDTSPHVPKYSPSTHPSEG---LEENYCRNPDNDEQG------ 161
Query: 275 RLWCYTSNPNVRFDYCDPPLCGNQYAY 355
WCYT++P+ R++YC+ P C + Y
Sbjct: 162 -PWCYTTDPDQRYEYCNIPECEEECMY 187
Score = 51.2 bits (121), Expect = 1e-06
Identities = 28/81 (34%), Positives = 40/81 (49%)
Frame = +2
Query: 95 YSGKLNKTIGGHICQKWSSQHPHKHNFISDWQFSERDILKAENFCRNPLLEKMGFHQAKD 274
Y G + T G CQ W S PH H S + D N+CRNP ++ G
Sbjct: 384 YRGTSSTTNTGKKCQSWVSMTPHSH---SKTPANFPDAGLEMNYCRNPDNDQRG------ 434
Query: 275 RLWCYTSNPNVRFDYCDPPLC 337
WC+T++P+VR++YC+ C
Sbjct: 435 -PWCFTTDPSVRWEYCNLKRC 454
>sp|P06867|PLMN_PIG Plasminogen precursor [Contains: Plasmin heavy chain A; Activation
peptide; Plasmin heavy chain A, short form; Plasmin
light chain B]
Length = 790
Score = 72.8 bits (177), Expect = 4e-13
Identities = 34/92 (36%), Positives = 53/92 (57%)
Frame = +2
Query: 62 DDICILESEIDYSGKLNKTIGGHICQKWSSQHPHKHNFISDWQFSERDILKAENFCRNPL 241
+D C+ S Y GK++KT+ G CQ W SQ PH H ++ +F +++ N+CRNP
Sbjct: 163 EDECMHCSGEHYEGKISKTMSGIECQSWGSQSPHAHGYLPS-KFPNKNL--KMNYCRNP- 218
Query: 242 LEKMGFHQAKDRLWCYTSNPNVRFDYCDPPLC 337
+ R WC+T++PN R+++CD P C
Sbjct: 219 -------DGEPRPWCFTTDPNKRWEFCDIPRC 243
Score = 72.8 bits (177), Expect = 4e-13
Identities = 35/91 (38%), Positives = 51/91 (56%)
Frame = +2
Query: 71 CILESEIDYSGKLNKTIGGHICQKWSSQHPHKHNFISDWQFSERDILKAENFCRNPLLEK 250
C+ +Y G ++ T GH CQ+WS+Q PHKHN + F +++ EN+CRNP
Sbjct: 256 CLKGRGENYRGTVSVTASGHTCQRWSAQSPHKHNRTPE-NFPCKNL--EENYCRNP---- 308
Query: 251 MGFHQAKDRLWCYTSNPNVRFDYCDPPLCGN 343
+ WCYT++ VR+DYC P CG+
Sbjct: 309 ----DGETAPWCYTTDSEVRWDYCKIPSCGS 335
Score = 69.7 bits (169), Expect = 3e-12
Identities = 37/96 (38%), Positives = 50/96 (52%)
Frame = +2
Query: 50 DLREDDICILESEIDYSGKLNKTIGGHICQKWSSQHPHKHNFISDWQFSERDILKAENFC 229
DL ED C+ + Y GK T+ G CQ+W++Q PH+H+ + + K N+C
Sbjct: 456 DLSED--CMFGNGKRYRGKRATTVAGVPCQEWAAQEPHRHSIFTPETNPRAGLEK--NYC 511
Query: 230 RNPLLEKMGFHQAKDRLWCYTSNPNVRFDYCDPPLC 337
RNP + G WCYT+NP FDYCD P C
Sbjct: 512 RNPDGDDNG-------PWCYTTNPQKLFDYCDVPQC 540
Score = 65.9 bits (159), Expect = 5e-11
Identities = 35/85 (41%), Positives = 47/85 (55%)
Frame = +2
Query: 92 DYSGKLNKTIGGHICQKWSSQHPHKHNFISDWQFSERDILKAENFCRNPLLEKMGFHQAK 271
+Y G +KT G ICQKWS PH + S +F + EN+CRNP ++ G
Sbjct: 91 NYRGTTSKTKSGVICQKWSVSSPHIPKY-SPEKFPLAGL--EENYCRNPDNDEKG----- 142
Query: 272 DRLWCYTSNPNVRFDYCDPPLCGNQ 346
WCYT++P RFDYCD P C ++
Sbjct: 143 --PWCYTTDPETRFDYCDIPECEDE 165
Score = 55.1 bits (131), Expect = 8e-08
Identities = 29/81 (35%), Positives = 40/81 (49%)
Frame = +2
Query: 95 YSGKLNKTIGGHICQKWSSQHPHKHNFISDWQFSERDILKAENFCRNPLLEKMGFHQAKD 274
Y G + TI G CQ W S PH+H + F + N+CRNP +K
Sbjct: 366 YRGTSSTTITGRKCQSWVSMTPHRHEK-TPGNFPNAGLTM--NYCRNPDADKSP------ 416
Query: 275 RLWCYTSNPNVRFDYCDPPLC 337
WCYT++P VR++YC+ C
Sbjct: 417 --WCYTTDPRVRWEYCNLKKC 435
>sp|P00747|PLMN_HUMAN Plasminogen precursor [Contains: Plasmin heavy chain A; Activation
peptide; Angiostatin; Plasmin heavy chain A, short form;
Plasmin light chain B]
Length = 810
Score = 72.0 bits (175), Expect = 6e-13
Identities = 36/92 (39%), Positives = 54/92 (58%)
Frame = +2
Query: 62 DDICILESEIDYSGKLNKTIGGHICQKWSSQHPHKHNFISDWQFSERDILKAENFCRNPL 241
++ C+ S +Y GK++KT+ G CQ W SQ PH H +I +F +++ K N+CRNP
Sbjct: 182 EEECMHCSGENYDGKISKTMSGLECQAWDSQSPHAHGYIPS-KFPNKNLKK--NYCRNPD 238
Query: 242 LEKMGFHQAKDRLWCYTSNPNVRFDYCDPPLC 337
E R WC+T++PN R++ CD P C
Sbjct: 239 REL--------RPWCFTTDPNKRWELCDIPRC 262
Score = 67.0 bits (162), Expect = 2e-11
Identities = 33/89 (37%), Positives = 48/89 (53%)
Frame = +2
Query: 71 CILESEIDYSGKLNKTIGGHICQKWSSQHPHKHNFISDWQFSERDILKAENFCRNPLLEK 250
C+ + +Y G + T+ GH CQ WS+Q PH HN + F +++ EN+CRNP
Sbjct: 275 CLKGTGENYRGNVAVTVSGHTCQHWSAQTPHTHNRTPE-NFPCKNL--DENYCRNP---- 327
Query: 251 MGFHQAKDRLWCYTSNPNVRFDYCDPPLC 337
K WC+T+N VR++YC P C
Sbjct: 328 ----DGKRAPWCHTTNSQVRWEYCKIPSC 352
Score = 64.7 bits (156), Expect = 1e-10
Identities = 32/92 (34%), Positives = 47/92 (51%)
Frame = +2
Query: 62 DDICILESEIDYSGKLNKTIGGHICQKWSSQHPHKHNFISDWQFSERDILKAENFCRNPL 241
++ C+ + Y GK T+ G CQ W++Q PH+H+ + + K N+CRNP
Sbjct: 478 EEDCMFGNGKGYRGKRATTVTGTPCQDWAAQEPHRHSIFTPETNPRAGLEK--NYCRNPD 535
Query: 242 LEKMGFHQAKDRLWCYTSNPNVRFDYCDPPLC 337
+ G WCYT+NP +DYCD P C
Sbjct: 536 GDVGG-------PWCYTTNPRKLYDYCDVPQC 560
Score = 64.3 bits (155), Expect = 1e-10
Identities = 33/78 (42%), Positives = 42/78 (53%)
Frame = +2
Query: 92 DYSGKLNKTIGGHICQKWSSQHPHKHNFISDWQFSERDILKAENFCRNPLLEKMGFHQAK 271
+Y G ++KT G CQKWSS PH+ F SE EN+CRNP + G
Sbjct: 110 NYRGTMSKTKNGITCQKWSSTSPHRPRFSPATHPSEG---LEENYCRNPDNDPQG----- 161
Query: 272 DRLWCYTSNPNVRFDYCD 325
WCYT++P R+DYCD
Sbjct: 162 --PWCYTTDPEKRYDYCD 177
Score = 53.1 bits (126), Expect = 3e-07
Identities = 28/86 (32%), Positives = 42/86 (48%)
Frame = +2
Query: 95 YSGKLNKTIGGHICQKWSSQHPHKHNFISDWQFSERDILKAENFCRNPLLEKMGFHQAKD 274
Y G + T G CQ WSS PH+H + + + N+CRNP +K
Sbjct: 385 YRGTSSTTTTGKKCQSWSSMTPHRHQKTPE---NYPNAGLTMNYCRNPDADKGP------ 435
Query: 275 RLWCYTSNPNVRFDYCDPPLCGNQYA 352
WC+T++P+VR++YC+ C A
Sbjct: 436 --WCFTTDPSVRWEYCNLKKCSGTEA 459
>sp|P26927|HGFL_HUMAN Hepatocyte growth factor-like protein precursor (Macrophage
stimulatory protein) (MSP) (Macrophage-stimulating
protein) [Contains: Hepatocyte growth factor-like
protein alpha chain; Hepatocyte growth factor-like
protein beta chain]
Length = 711
Score = 72.0 bits (175), Expect = 6e-13
Identities = 32/102 (31%), Positives = 56/102 (54%)
Frame = +2
Query: 41 CHLDLREDDICILESEIDYSGKLNKTIGGHICQKWSSQHPHKHNFISDWQFSERDILKAE 220
C + + C+ + +Y G +++T G CQ+W QHPH+H F +F ++ + +
Sbjct: 181 CGIKSCREAACVWCNGEEYRGAVDRTESGRECQRWDLQHPHQHPF-EPGKFLDQGL--DD 237
Query: 221 NFCRNPLLEKMGFHQAKDRLWCYTSNPNVRFDYCDPPLCGNQ 346
N+CRNP +R WCYT++P + ++CD P CG++
Sbjct: 238 NYCRNP--------DGSERPWCYTTDPQIEREFCDLPRCGSE 271
Score = 62.8 bits (151), Expect = 4e-10
Identities = 38/104 (36%), Positives = 49/104 (47%)
Frame = +2
Query: 32 VNGCHLDLREDDICILESEIDYSGKLNKTIGGHICQKWSSQHPHKHNFISDWQFSERDIL 211
+ C D+R D C + Y G ++KT G CQ+WS++ PHK F SE
Sbjct: 358 IRRCTDDVRPQD-CYHGAGEQYRGTVSKTRKGVQCQRWSAETPHKPQFTFT---SEPHAQ 413
Query: 212 KAENFCRNPLLEKMGFHQAKDRLWCYTSNPNVRFDYCDPPLCGN 343
ENFCRNP + G WCYT +P FDYC C +
Sbjct: 414 LEENFCRNPDGDSHG-------PWCYTMDPRTPFDYCALRRCAD 450
Score = 60.8 bits (146), Expect = 1e-09
Identities = 36/101 (35%), Positives = 53/101 (52%), Gaps = 2/101 (1%)
Frame = +2
Query: 41 CHLDLREDDI--CILESEIDYSGKLNKTIGGHICQKWSSQHPHKHNFISDWQFSERDILK 214
C L ++D + CI+ + + Y G + T+GG CQ WS + P+ H + + R+ L+
Sbjct: 98 CDLFQKKDYVRTCIMNNGVGYRGTMATTVGGLPCQAWSHKFPNDHKYTP----TLRNGLE 153
Query: 215 AENFCRNPLLEKMGFHQAKDRLWCYTSNPNVRFDYCDPPLC 337
ENFCRNP + G WCYT++P VRF C C
Sbjct: 154 -ENFCRNPDGDPGG-------PWCYTTDPAVRFQSCGIKSC 186
Score = 56.2 bits (134), Expect = 4e-08
Identities = 27/76 (35%), Positives = 40/76 (52%)
Frame = +2
Query: 95 YSGKLNKTIGGHICQKWSSQHPHKHNFISDWQFSERDILKAENFCRNPLLEKMGFHQAKD 274
Y G N T G CQ+W +Q PH+H F + +++ +D+ ENFCRNP +
Sbjct: 291 YRGTANTTTAGVPCQRWDAQIPHQHRFTPE-KYACKDL--RENFCRNP--------DGSE 339
Query: 275 RLWCYTSNPNVRFDYC 322
WC+T P +R +C
Sbjct: 340 APWCFTLRPGMRAAFC 355
>sp|P06868|PLMN_BOVIN Plasminogen precursor [Contains: Plasmin heavy chain A; Activation
peptide; Plasmin heavy chain A, short form; Plasmin
light chain B]
Length = 812
Score = 71.6 bits (174), Expect = 8e-13
Identities = 34/92 (36%), Positives = 52/92 (56%)
Frame = +2
Query: 62 DDICILESEIDYSGKLNKTIGGHICQKWSSQHPHKHNFISDWQFSERDILKAENFCRNPL 241
+D C+ S +Y GK+ KT+ G CQ W SQ PH H +I +F +++ N+CRNP
Sbjct: 189 EDKCMHCSGENYEGKIAKTMSGRDCQAWDSQSPHAHGYIPS-KFPNKNL--KMNYCRNP- 244
Query: 242 LEKMGFHQAKDRLWCYTSNPNVRFDYCDPPLC 337
+ R WC+T++P R+++CD P C
Sbjct: 245 -------DGEPRPWCFTTDPQKRWEFCDIPRC 269
Score = 70.5 bits (171), Expect = 2e-12
Identities = 36/89 (40%), Positives = 49/89 (55%)
Frame = +2
Query: 71 CILESEIDYSGKLNKTIGGHICQKWSSQHPHKHNFISDWQFSERDILKAENFCRNPLLEK 250
C+ + +Y G + T GH CQ+WS Q PHKHN + F +++ EN+CRNP EK
Sbjct: 282 CLKGTGKNYGGTVAVTESGHTCQRWSEQTPHKHNRTPE-NFPCKNL--EENYCRNPNGEK 338
Query: 251 MGFHQAKDRLWCYTSNPNVRFDYCDPPLC 337
WCYT+N VR++YC P C
Sbjct: 339 AP--------WCYTTNSEVRWEYCTIPSC 359
Score = 67.4 bits (163), Expect = 2e-11
Identities = 32/93 (34%), Positives = 49/93 (52%)
Frame = +2
Query: 71 CILESEIDYSGKLNKTIGGHICQKWSSQHPHKHNFISDWQFSERDILKAENFCRNPLLEK 250
C++ + Y GK T+ G CQ+W++Q PH+H+ + + + + N+CRNP +
Sbjct: 485 CMIGTGKSYRGKKATTVAGVPCQEWAAQEPHQHSIFTPETNPQSGLER--NYCRNPDGDV 542
Query: 251 MGFHQAKDRLWCYTSNPNVRFDYCDPPLCGNQY 349
G WCYT NP FDYCD P C + +
Sbjct: 543 NG-------PWCYTMNPRKPFDYCDVPQCESSF 568
Score = 60.8 bits (146), Expect = 1e-09
Identities = 33/81 (40%), Positives = 44/81 (54%)
Frame = +2
Query: 95 YSGKLNKTIGGHICQKWSSQHPHKHNFISDWQFSERDILKAENFCRNPLLEKMGFHQAKD 274
Y G +T G CQKWS+ PH F S +F + EN+CRNP ++ G
Sbjct: 118 YRGTTAETKSGVTCQKWSATSPHVPKF-SPEKFPLAGL--EENYCRNPDNDENG------ 168
Query: 275 RLWCYTSNPNVRFDYCDPPLC 337
WCYT++P+ R+DYCD P C
Sbjct: 169 -PWCYTTDPDKRYDYCDIPEC 188
Score = 54.3 bits (129), Expect = 1e-07
Identities = 28/81 (34%), Positives = 41/81 (50%)
Frame = +2
Query: 95 YSGKLNKTIGGHICQKWSSQHPHKHNFISDWQFSERDILKAENFCRNPLLEKMGFHQAKD 274
Y G + TI G CQ WSS PH+H + + + N+CRNP +K
Sbjct: 392 YRGTSSTTITGRKCQSWSSMTPHRHLKTPE---NYPNAGLTMNYCRNPDADKSP------ 442
Query: 275 RLWCYTSNPNVRFDYCDPPLC 337
WCYT++P VR+++C+ C
Sbjct: 443 --WCYTTDPRVRWEFCNLKKC 461
>sp|P14210|HGF_HUMAN Hepatocyte growth factor precursor (Scatter factor) (SF)
(Hepatopoeitin A) [Contains: Hepatocyte growth factor
alpha chain; Hepatocyte growth factor beta chain]
Length = 728
Score = 71.2 bits (173), Expect = 1e-12
Identities = 36/89 (40%), Positives = 50/89 (56%)
Frame = +2
Query: 71 CILESEIDYSGKLNKTIGGHICQKWSSQHPHKHNFISDWQFSERDILKAENFCRNPLLEK 250
CI+ Y G ++ T G CQ WSS PH+H+F+ + +D+ EN+CRNP E+
Sbjct: 128 CIIGKGRSYKGTVSITKSGIKCQPWSSMIPHEHSFLPS-SYRGKDL--QENYCRNPRGEE 184
Query: 251 MGFHQAKDRLWCYTSNPNVRFDYCDPPLC 337
G WC+TSNP VR++ CD P C
Sbjct: 185 GG-------PWCFTSNPEVRYEVCDIPQC 206
Score = 63.5 bits (153), Expect = 2e-10
Identities = 29/91 (31%), Positives = 49/91 (53%)
Frame = +2
Query: 71 CILESEIDYSGKLNKTIGGHICQKWSSQHPHKHNFISDWQFSERDILKAENFCRNPLLEK 250
C+ + Y G ++ T G ICQ+W Q PH+H F+ + ++ ++ +N+CRNP
Sbjct: 211 CMTCNGESYRGLMDHTESGKICQRWDHQTPHRHKFLPE-RYPDKGF--DDNYCRNP---- 263
Query: 251 MGFHQAKDRLWCYTSNPNVRFDYCDPPLCGN 343
+ R WCYT +P+ R++YC C +
Sbjct: 264 ----DGQPRPWCYTLDPHTRWEYCAIKTCAD 290
Score = 63.5 bits (153), Expect = 2e-10
Identities = 40/122 (32%), Positives = 59/122 (48%), Gaps = 3/122 (2%)
Frame = +2
Query: 71 CILESEIDYSGKLNKTIGGHICQKWSSQHPHKHNFISDWQFSERDILKAENFCRNPLLEK 250
CI Y G +N G CQ+W SQ+PH+H+ + F +D+ EN+CRNP
Sbjct: 305 CIQGQGEGYRGTVNTIWNGIPCQRWDSQYPHEHDMTPE-NFKCKDL--RENYCRNP---- 357
Query: 251 MGFHQAKDRLWCYTSNPNVRFDYCDP-PLCGNQYAYNDKRR*I*MNF--N*KQMKSTIKC 421
+ WC+T++PN+R YC P C + D R N+ N Q +S + C
Sbjct: 358 ----DGSESPWCFTTDPNIRVGYCSQIPNCDMSHG-QDCYRGNGKNYMGNLSQTRSGLTC 412
Query: 422 SL 427
S+
Sbjct: 413 SM 414
Score = 51.2 bits (121), Expect = 1e-06
Identities = 32/97 (32%), Positives = 41/97 (42%), Gaps = 1/97 (1%)
Frame = +2
Query: 50 DLREDDICILESEIDYSGKLNKTIGGHICQKWSSQHPHKHNFISDWQFSERDILKA-ENF 226
D+ C + +Y G L++T G C W H I F E D K EN+
Sbjct: 384 DMSHGQDCYRGNGKNYMGNLSQTRSGLTCSMWDKNMEDLHRHI----FWEPDASKLNENY 439
Query: 227 CRNPLLEKMGFHQAKDRLWCYTSNPNVRFDYCDPPLC 337
CRNP + G WCYT NP + +DYC C
Sbjct: 440 CRNPDDDAHG-------PWCYTGNPLIPWDYCPISRC 469
>sp|P20918|PLMN_MOUSE Plasminogen precursor [Contains: Plasmin heavy chain A; Activation
peptide; Angiostatin; Plasmin heavy chain A, short form;
Plasmin light chain B]
Length = 812
Score = 71.2 bits (173), Expect = 1e-12
Identities = 36/99 (36%), Positives = 56/99 (56%)
Frame = +2
Query: 41 CHLDLREDDICILESEIDYSGKLNKTIGGHICQKWSSQHPHKHNFISDWQFSERDILKAE 220
C++ E++ C+ S Y GK++KT+ G CQ W SQ PH H +I +F +++
Sbjct: 176 CNIPECEEE-CMYCSGEKYEGKISKTMSGLDCQAWDSQSPHAHGYIPA-KFPSKNL--KM 231
Query: 221 NFCRNPLLEKMGFHQAKDRLWCYTSNPNVRFDYCDPPLC 337
N+CRNP + R WC+T++P R++YCD P C
Sbjct: 232 NYCRNP--------DGEPRPWCFTTDPTKRWEYCDIPRC 262
Score = 69.7 bits (169), Expect = 3e-12
Identities = 36/95 (37%), Positives = 53/95 (55%)
Frame = +2
Query: 71 CILESEIDYSGKLNKTIGGHICQKWSSQHPHKHNFISDWQFSERDILKAENFCRNPLLEK 250
C+ + DY GK T G CQ W++Q PH+H+ + Q + R L+ +N+CRNP +
Sbjct: 481 CMYGNGKDYRGKTAVTAAGTPCQGWAAQEPHRHSIFTP-QTNPRAGLE-KNYCRNPDGDV 538
Query: 251 MGFHQAKDRLWCYTSNPNVRFDYCDPPLCGNQYAY 355
G WCYT+NP +DYCD PLC + ++
Sbjct: 539 NG-------PWCYTTNPRKLYDYCDIPLCASASSF 566
Score = 64.7 bits (156), Expect = 1e-10
Identities = 30/89 (33%), Positives = 49/89 (55%)
Frame = +2
Query: 71 CILESEIDYSGKLNKTIGGHICQKWSSQHPHKHNFISDWQFSERDILKAENFCRNPLLEK 250
C+ +Y G ++ T+ G CQ+WS Q PH+HN + F +++ EN+CRNP
Sbjct: 275 CLKGRGENYRGTVSVTVSGKTCQRWSEQTPHRHNRTPE-NFPCKNL--EENYCRNP---- 327
Query: 251 MGFHQAKDRLWCYTSNPNVRFDYCDPPLC 337
+ WCYT++ +R++YC+ P C
Sbjct: 328 ----DGETAPWCYTTDSQLRWEYCEIPSC 352
Score = 63.9 bits (154), Expect = 2e-10
Identities = 31/87 (35%), Positives = 46/87 (52%)
Frame = +2
Query: 95 YSGKLNKTIGGHICQKWSSQHPHKHNFISDWQFSERDILKAENFCRNPLLEKMGFHQAKD 274
Y G +++T G CQKW + PH N+ +E EN+CRNP ++ G
Sbjct: 111 YRGTMSRTKSGVACQKWGATFPHVPNYSPSTHPNEG---LEENYCRNPDNDEQG------ 161
Query: 275 RLWCYTSNPNVRFDYCDPPLCGNQYAY 355
WCYT++P+ R+DYC+ P C + Y
Sbjct: 162 -PWCYTTDPDKRYDYCNIPECEEECMY 187
Score = 55.5 bits (132), Expect = 6e-08
Identities = 29/89 (32%), Positives = 45/89 (50%)
Frame = +2
Query: 71 CILESEIDYSGKLNKTIGGHICQKWSSQHPHKHNFISDWQFSERDILKAENFCRNPLLEK 250
C Y G + TI G CQ W++ PH+H+ + F + + N+CRNP +K
Sbjct: 377 CYQSDGQSYRGTSSTTITGKKCQSWAAMFPHRHSKTPE-NFPDAGL--EMNYCRNPDGDK 433
Query: 251 MGFHQAKDRLWCYTSNPNVRFDYCDPPLC 337
WCYT++P+VR++YC+ C
Sbjct: 434 GP--------WCYTTDPSVRWEYCNLKRC 454
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 53,817,593
Number of Sequences: 369166
Number of extensions: 1034987
Number of successful extensions: 2612
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 2293
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 2445
length of database: 68,354,980
effective HSP length: 101
effective length of database: 49,696,745
effective search space used: 2783017720
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)