Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_027_N20
(816 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P58003|SESN1_XENLA Sestrin-1 (p53-regulated protein PA26... 134 3e-31
sp|Q9Y6P5|SESN1_HUMAN Sestrin-1 (p53-regulated protein PA26) 134 4e-31
sp|Q9W1K5|SEST_DROME Putative sestrin 134 4e-31
sp|P58006|SESN1_MOUSE Sestrin-1 (p53-regulated protein PA26) 132 9e-31
sp|P58005|SESN3_HUMAN Sestrin-3 131 2e-30
sp|Q9CYP7|SESN3_MOUSE Sestrin-3 129 1e-29
sp|P58004|SESN2_HUMAN Sestrin-2 (Hi95) 128 2e-29
sp|P58043|SESN2_MOUSE Sestrin-2 121 2e-27
sp|Q9N4D6|SEST_CAEEL Putative sestrin 81 4e-15
sp|P44586|DEAD_HAEIN Cold-shock DEAD-box protein A homolog ... 31 4.6
>sp|P58003|SESN1_XENLA Sestrin-1 (p53-regulated protein PA26) (XPA26)
Length = 481
Score = 134 bits (337), Expect = 3e-31
Identities = 66/197 (33%), Positives = 114/197 (57%), Gaps = 2/197 (1%)
Frame = +2
Query: 2 EVAEDDVVKMFLSVEKENETIIKNQNHPKEVNPLIERFIEDPNFTYISYNSNNAEV--LR 175
E +++++ F EK + ++ + + R ED ++ Y ++ V R
Sbjct: 281 EASQEEMATRF-EREKTESMVFSTEDEDPPPDIDVSRHFEDTSYGYKDFSRRGMHVPTFR 339
Query: 176 MQEYSWSDEACCLADRFYTDIGKALEDKFNCSYDLTYNTMGDKTNIDTTIFRLSVWIYVH 355
+Q+YSW D L +R Y D+G+ L++KF+ +Y+LTYNTM ++DT+ R +VW YVH
Sbjct: 340 VQDYSWEDHGYSLVNRLYPDVGQLLDEKFHIAYNLTYNTMAMHKDVDTSTLRRAVWNYVH 399
Query: 356 SLYGIRHDDFNYAQMDILLTNPLKTFLKKAMTKPCTSKKSDLFRFFPEFKISEKVHIALM 535
++GIR+DD++Y +++ LL K ++K + P + K F+ +FK SEKVH+ L+
Sbjct: 400 CMFGIRYDDYDYGEINQLLDRSFKVYIKNVVCSPEKTSKRMYDGFWRQFKHSEKVHVNLL 459
Query: 536 AADARQQACLLHILKAM 586
+AR Q LL+ L+A+
Sbjct: 460 LMEARMQGELLYALRAI 476
>sp|Q9Y6P5|SESN1_HUMAN Sestrin-1 (p53-regulated protein PA26)
Length = 492
Score = 134 bits (336), Expect = 4e-31
Identities = 65/199 (32%), Positives = 120/199 (60%), Gaps = 4/199 (2%)
Frame = +2
Query: 2 EVAEDDVVKMFLSVEKENETIIKNQNHPKEVNPL--IERFIEDPNFTYISYNSNNAEV-- 169
E +++++ F ++E+ + + + +EV P + R ED ++ Y ++ + V
Sbjct: 291 EASQEEMASRFEIEKRESMFVFSSDD--EEVTPARAVSRHFEDTSYGYKDFSRHGMHVPT 348
Query: 170 LRMQEYSWSDEACCLADRFYTDIGKALEDKFNCSYDLTYNTMGDKTNIDTTIFRLSVWIY 349
R+Q+Y W D L +R Y D+G+ +++KF+ +Y+LTYNTM ++DT++ R ++W Y
Sbjct: 349 FRVQDYCWEDHGYSLVNRLYPDVGQLIDEKFHIAYNLTYNTMAMHKDVDTSMLRRAIWNY 408
Query: 350 VHSLYGIRHDDFNYAQMDILLTNPLKTFLKKAMTKPCTSKKSDLFRFFPEFKISEKVHIA 529
+H ++GIR+DD++Y +++ LL K ++K + P K F+ +FK SEKVH+
Sbjct: 409 IHCMFGIRYDDYDYGEINQLLDRSFKVYIKTVVCTPEKVTKRMYDSFWRQFKHSEKVHVN 468
Query: 530 LMAADARQQACLLHILKAM 586
L+ +AR QA LL+ L+A+
Sbjct: 469 LLLIEARMQAELLYALRAI 487
>sp|Q9W1K5|SEST_DROME Putative sestrin
Length = 497
Score = 134 bits (336), Expect = 4e-31
Identities = 73/197 (37%), Positives = 107/197 (54%), Gaps = 4/197 (2%)
Frame = +2
Query: 2 EVAEDDVVKMFLSVEKEN-ETIIKNQNHPKEVNPLIERFIEDPNFTYISYNSNNAEVL-- 172
E +E ++ F VE++ E V + +++D NF Y + E +
Sbjct: 294 ECSEAELSSRFQKVEQQTAELAAVTPEAAVGVPTNLSHYVDDANFIYQDFARRGTESINT 353
Query: 173 -RMQEYSWSDEACCLADRFYTDIGKALEDKFNCSYDLTYNTMGDKTNIDTTIFRLSVWIY 349
R+Q+YSW D L D Y D+G L+ KF +Y+LTY TMG N+DT+ FR ++W Y
Sbjct: 354 FRIQDYSWEDHGYSLVDGLYNDVGIFLDAKFRAAYNLTYCTMGGIKNVDTSKFRRAIWNY 413
Query: 350 VHSLYGIRHDDFNYAQMDILLTNPLKTFLKKAMTKPCTSKKSDLFRFFPEFKISEKVHIA 529
+ +YGIRHDD++Y +++ LL PLK F+K A P D E + SEKVH+
Sbjct: 414 IQCIYGIRHDDYDYGEVNQLLVRPLKMFIKTACCFPERITTKDYDSVLVELQDSEKVHVN 473
Query: 530 LMAADARQQACLLHILK 580
LM +AR QA LL+ L+
Sbjct: 474 LMIMEARNQAELLYALR 490
>sp|P58006|SESN1_MOUSE Sestrin-1 (p53-regulated protein PA26)
Length = 492
Score = 132 bits (333), Expect = 9e-31
Identities = 65/199 (32%), Positives = 118/199 (59%), Gaps = 4/199 (2%)
Frame = +2
Query: 2 EVAEDDVVKMFLSVEKENETIIKNQNHPKEVNPL--IERFIEDPNFTYISYNSNNAEV-- 169
E +++++ F ++E+ + + + EV P + R ED ++ Y ++ + V
Sbjct: 291 EASQEEMASRFEMEKRESMFVFSSDDD--EVTPARDVSRHFEDTSYGYKDFSRHGMHVPT 348
Query: 170 LRMQEYSWSDEACCLADRFYTDIGKALEDKFNCSYDLTYNTMGDKTNIDTTIFRLSVWIY 349
R+Q+Y W D L +R Y D+G+ +++KF+ Y+LTYNTM ++DT++ R ++W Y
Sbjct: 349 FRVQDYCWEDHGYSLVNRLYPDVGQLIDEKFHIPYNLTYNTMAMHKDVDTSMLRRAIWNY 408
Query: 350 VHSLYGIRHDDFNYAQMDILLTNPLKTFLKKAMTKPCTSKKSDLFRFFPEFKISEKVHIA 529
+H ++GIR+DD++Y +++ LL K ++K + P K F+ +FK SEKVH+
Sbjct: 409 IHCMFGIRYDDYDYGEINQLLDRSFKVYIKTVVCTPEKVTKRMYDSFWRQFKHSEKVHVN 468
Query: 530 LMAADARQQACLLHILKAM 586
L+ +AR QA LL+ L+A+
Sbjct: 469 LLLIEARMQAELLYALRAI 487
>sp|P58005|SESN3_HUMAN Sestrin-3
Length = 492
Score = 131 bits (330), Expect = 2e-30
Identities = 65/164 (39%), Positives = 102/164 (62%), Gaps = 3/164 (1%)
Frame = +2
Query: 104 IERFIEDPNFTYISYNSNNAEVL---RMQEYSWSDEACCLADRFYTDIGKALEDKFNCSY 274
+ R+IEDP F Y + E L R Q+Y+W + L +R Y+DIG L++KF Y
Sbjct: 324 VSRYIEDPGFGYEDFARRGEEHLPTFRAQDYTWENHGFSLVNRLYSDIGHLLDEKFRMVY 383
Query: 275 DLTYNTMGDKTNIDTTIFRLSVWIYVHSLYGIRHDDFNYAQMDILLTNPLKTFLKKAMTK 454
+LTYNTM ++DTT+ R +++ YVH ++GIR+DD++Y +++ LL LK ++K
Sbjct: 384 NLTYNTMATHEDVDTTMLRRALFNYVHCMFGIRYDDYDYGEVNQLLERSLKVYIKTVTCY 443
Query: 455 PCTSKKSDLFRFFPEFKISEKVHIALMAADARQQACLLHILKAM 586
P + K ++ +FK SEKVH+ L+ +AR QA LL+ L+A+
Sbjct: 444 PERTTKRMYDSYWRQFKHSEKVHVNLLLMEARMQAELLYALRAI 487
>sp|Q9CYP7|SESN3_MOUSE Sestrin-3
Length = 492
Score = 129 bits (323), Expect = 1e-29
Identities = 64/164 (39%), Positives = 101/164 (61%), Gaps = 3/164 (1%)
Frame = +2
Query: 104 IERFIEDPNFTYISYNSNNAEVL---RMQEYSWSDEACCLADRFYTDIGKALEDKFNCSY 274
+ R+IEDP+F Y + E L R Q+Y+W + L +R Y+DIG L++KF Y
Sbjct: 324 VSRYIEDPSFGYEDFARRGEEHLPTFRAQDYTWENHGFSLVNRLYSDIGHLLDEKFRMVY 383
Query: 275 DLTYNTMGDKTNIDTTIFRLSVWIYVHSLYGIRHDDFNYAQMDILLTNPLKTFLKKAMTK 454
+LTYNTM ++DTT R +++ YVH ++GIR+DD++Y +++ LL LK ++K
Sbjct: 384 NLTYNTMATHEDVDTTTLRRALFNYVHCMFGIRYDDYDYGEVNQLLERSLKVYIKTVTCY 443
Query: 455 PCTSKKSDLFRFFPEFKISEKVHIALMAADARQQACLLHILKAM 586
P + K ++ +F SEKVH+ L+ +AR QA LL+ L+A+
Sbjct: 444 PERTTKRMYDSYWRQFTHSEKVHVNLLLMEARMQAELLYALRAI 487
>sp|P58004|SESN2_HUMAN Sestrin-2 (Hi95)
Length = 480
Score = 128 bits (321), Expect = 2e-29
Identities = 59/161 (36%), Positives = 97/161 (60%), Gaps = 3/161 (1%)
Frame = +2
Query: 113 FIEDPNFTYISYNSNNAEV---LRMQEYSWSDEACCLADRFYTDIGKALEDKFNCSYDLT 283
F+EDP F Y + A+ R Q+Y+W D L R Y + G+ L++KF +Y LT
Sbjct: 315 FVEDPTFGYEDFTRRGAQAPPTFRAQDYTWEDHGYSLIQRLYPEGGQLLDEKFQAAYSLT 374
Query: 284 YNTMGDKTNIDTTIFRLSVWIYVHSLYGIRHDDFNYAQMDILLTNPLKTFLKKAMTKPCT 463
YNT+ + +DT++ R ++W Y+H ++GIR+DD++Y +++ LL LK ++K P
Sbjct: 375 YNTIAMHSGVDTSVLRRAIWNYIHCVFGIRYDDYDYGEVNQLLERNLKVYIKTVACYPEK 434
Query: 464 SKKSDLFRFFPEFKISEKVHIALMAADARQQACLLHILKAM 586
+ + F+ F+ SEKVH+ L+ +AR QA LL+ L+A+
Sbjct: 435 TTRRMYNLFWRHFRHSEKVHVNLLLLEARMQAALLYALRAI 475
>sp|P58043|SESN2_MOUSE Sestrin-2
Length = 480
Score = 121 bits (304), Expect = 2e-27
Identities = 59/167 (35%), Positives = 98/167 (58%), Gaps = 3/167 (1%)
Frame = +2
Query: 95 NPLIERFIEDPNFTYISYNSNNAEV---LRMQEYSWSDEACCLADRFYTDIGKALEDKFN 265
+P I F+EDP F Y + + R Q+Y+W D L R Y + G+ L++KF
Sbjct: 309 HPDILCFVEDPAFGYEDFTRRGTQAPPTFRAQDYTWEDHGYSLIQRLYPEGGQLLDEKFQ 368
Query: 266 CSYDLTYNTMGDKTNIDTTIFRLSVWIYVHSLYGIRHDDFNYAQMDILLTNPLKTFLKKA 445
+ LTYNT+ + +DT++ R ++W Y+H ++GIR+DD++Y +++ LL LK ++K
Sbjct: 369 VACSLTYNTIAMHSGVDTSMLRRAIWNYIHCVFGIRYDDYDYGEVNQLLERNLKIYIKTV 428
Query: 446 MTKPCTSKKSDLFRFFPEFKISEKVHIALMAADARQQACLLHILKAM 586
P + + F+ F+ SEKVH+ L+ +AR QA LL+ L+A+
Sbjct: 429 ACYPEKTTRRMYNLFWRHFRHSEKVHVNLLLLEARMQAALLYALRAI 475
>sp|Q9N4D6|SEST_CAEEL Putative sestrin
Length = 517
Score = 80.9 bits (198), Expect = 4e-15
Identities = 49/155 (31%), Positives = 81/155 (52%), Gaps = 3/155 (1%)
Frame = +2
Query: 131 FTYISYNSNNAEVL---RMQEYSWSDEACCLADRFYTDIGKALEDKFNCSYDLTYNTMGD 301
F YI + + + R++E+ W D + + + L+ F+ LT N + +
Sbjct: 350 FGYIDFRKRPEKDIPPFRVEEFGW-DHVYNTMNEYTDTLTSRLDRMFDHIRTLTGNMLNE 408
Query: 302 KTNIDTTIFRLSVWIYVHSLYGIRHDDFNYAQMDILLTNPLKTFLKKAMTKPCTSKKSDL 481
IDT FR ++W Y LYG+R DD++Y++++ +L KTF+K A P ++
Sbjct: 409 ---IDTAAFREAIWNYTQGLYGVRVDDYDYSKINRVLDKGTKTFIKLAACYP-HKLTTEF 464
Query: 482 FRFFPEFKISEKVHIALMAADARQQACLLHILKAM 586
R P FK SEK+H+ +M A AR QA + H +A+
Sbjct: 465 TRALPGFKDSEKIHVVMMVAMARFQASMFHYTRAV 499
>sp|P44586|DEAD_HAEIN Cold-shock DEAD-box protein A homolog (ATP-dependent RNA helicase
deaD homolog)
Length = 613
Score = 30.8 bits (68), Expect = 4.6
Identities = 13/50 (26%), Positives = 26/50 (52%)
Frame = +2
Query: 14 DDVVKMFLSVEKENETIIKNQNHPKEVNPLIERFIEDPNFTYISYNSNNA 163
DDV + + + ++T + + P+ + + +RF+ DP I N+ NA
Sbjct: 167 DDVETVMAELPENHQTALFSATMPEPIRRITKRFMNDPQEVKIKVNNENA 216
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 86,842,482
Number of Sequences: 369166
Number of extensions: 1755407
Number of successful extensions: 4400
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 4271
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 4395
length of database: 68,354,980
effective HSP length: 109
effective length of database: 48,218,865
effective search space used: 7811456130
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)