Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_027_N14
(485 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q9NYB9|ABI2_HUMAN Abl-interactor 2 (Abelson interactor 2... 105 7e-23
sp|P62484|ABI2_MOUSE Abl-interactor 2 (Abelson interactor 2... 104 9e-23
sp|Q8IZP0|ABI1_HUMAN Abl-interactor 1 (Abelson interactor 1... 99 5e-21
sp|Q8CBW3|ABI1_MOUSE Abl-interactor 1 (Abelson interactor 1... 99 5e-21
sp|Q9QZM5|ABI1_RAT Abl-interactor 1 (Abelson interactor 1) ... 99 5e-21
sp|Q9P2A4|ABI3_HUMAN ABI gene family member 3 (New molecule... 86 6e-17
sp|Q8BYZ1|ABI3_MOUSE ABI gene family member 3 (New molecule... 80 3e-15
sp|Q9NZM3|ITSN2_HUMAN Intersectin-2 (SH3 domain-containing ... 72 9e-13
sp|Q9Z0R6|ITSN2_MOUSE Intersectin-2 (SH3 domain-containing ... 71 1e-12
sp|Q15811|ITSN1_HUMAN Intersectin 1 (SH3 domain-containing ... 66 4e-11
>sp|Q9NYB9|ABI2_HUMAN Abl-interactor 2 (Abelson interactor 2) (Abi-2) (Abl-binding
protein 3) (AblBP3) (Arg-binding protein 1) (ArgBP1)
Length = 513
Score = 105 bits (261), Expect = 7e-23
Identities = 53/116 (45%), Positives = 72/116 (62%)
Frame = +1
Query: 49 PPPPNVEQFQRPPSNEQINIDKNQNRYISDSVGIAHLQPTPYDVLRIKSQSDEVWAPSQY 228
PPPP VE+ P +E Y + + PY ++ D WAP Y
Sbjct: 403 PPPPPVEE---PVFDESPPPPPPPEDYEEEEAAVVEYSD-PY------AEEDPPWAPRSY 452
Query: 229 ICKVVTLYEYLQNKDDELSFQENELIYVVKKNNDGWWEGVMNGRTGLFPGNYVQNL 396
+ KVV +Y+Y ++K+DELSFQE +IYV+KKN+DGW+EGVMNG TGLFPGNYV+++
Sbjct: 453 LEKVVAIYDYTKDKEDELSFQEGAIIYVIKKNDDGWYEGVMNGVTGLFPGNYVESI 508
>sp|P62484|ABI2_MOUSE Abl-interactor 2 (Abelson interactor 2) (Abi-2)
Length = 446
Score = 104 bits (260), Expect = 9e-23
Identities = 53/116 (45%), Positives = 72/116 (62%)
Frame = +1
Query: 49 PPPPNVEQFQRPPSNEQINIDKNQNRYISDSVGIAHLQPTPYDVLRIKSQSDEVWAPSQY 228
PPPP VE+ P +E Y + + PY ++ D WAP Y
Sbjct: 336 PPPPPVEE---PVFDESPPPPPPPEDYEEEEAAVVEYSD-PY------AEEDPPWAPRAY 385
Query: 229 ICKVVTLYEYLQNKDDELSFQENELIYVVKKNNDGWWEGVMNGRTGLFPGNYVQNL 396
+ KVV +Y+Y ++K+DELSFQE +IYV+KKN+DGW+EGVMNG TGLFPGNYV+++
Sbjct: 386 LEKVVAIYDYTKDKEDELSFQEGAIIYVIKKNDDGWYEGVMNGVTGLFPGNYVESI 441
>sp|Q8IZP0|ABI1_HUMAN Abl-interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3
domain-binding protein 1) (Eps8 SH3 domain-binding
protein) (Eps8-binding protein) (e3B1) (Nap1-binding
protein) (Nap1BP) (Abl-binding protein 4) (AblBP4)
Length = 508
Score = 99.0 bits (245), Expect = 5e-21
Identities = 51/117 (43%), Positives = 68/117 (58%), Gaps = 1/117 (0%)
Frame = +1
Query: 49 PPPPNVEQFQ-RPPSNEQINIDKNQNRYISDSVGIAHLQPTPYDVLRIKSQSDEVWAPSQ 225
PPP ++ F PP +D Y + + PY + D WAP
Sbjct: 399 PPPDDIPMFDDSPPPPPPPPVD-----YEDEEAAVVQYND-PY------ADGDPAWAPKN 446
Query: 226 YICKVVTLYEYLQNKDDELSFQENELIYVVKKNNDGWWEGVMNGRTGLFPGNYVQNL 396
YI KVV +Y+Y ++KDDELSF E +IYV+KKN+DGW+EGV N TGLFPGNYV+++
Sbjct: 447 YIEKVVAIYDYTKDKDDELSFMEGAIIYVIKKNDDGWYEGVCNRVTGLFPGNYVESI 503
>sp|Q8CBW3|ABI1_MOUSE Abl-interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3
domain-binding protein 1) (Eps8 SH3 domain-binding
protein) (Eps8-binding protein) (e3B1) (Ablphilin-1)
Length = 481
Score = 99.0 bits (245), Expect = 5e-21
Identities = 50/119 (42%), Positives = 70/119 (58%), Gaps = 3/119 (2%)
Frame = +1
Query: 49 PPPPNVEQFQR---PPSNEQINIDKNQNRYISDSVGIAHLQPTPYDVLRIKSQSDEVWAP 219
PPP ++ F PP ++ + + + S PY + D WAP
Sbjct: 372 PPPDDIPMFDDSPPPPPPPPVDYEDEEAAVVQYS--------DPY------ADGDPAWAP 417
Query: 220 SQYICKVVTLYEYLQNKDDELSFQENELIYVVKKNNDGWWEGVMNGRTGLFPGNYVQNL 396
YI KVV +Y+Y ++KDDELSF+E +IYV+KKN+DGW+EGV N TGLFPGNYV+++
Sbjct: 418 KNYIEKVVAIYDYTKDKDDELSFKEGAIIYVIKKNDDGWFEGVCNRVTGLFPGNYVESI 476
>sp|Q9QZM5|ABI1_RAT Abl-interactor 1 (Abelson interactor 1) (Abi-1) (Eps8 SH3 domain
binding protein) (Eps8 binding protein) (e3B1)
Length = 476
Score = 99.0 bits (245), Expect = 5e-21
Identities = 50/119 (42%), Positives = 70/119 (58%), Gaps = 3/119 (2%)
Frame = +1
Query: 49 PPPPNVEQFQR---PPSNEQINIDKNQNRYISDSVGIAHLQPTPYDVLRIKSQSDEVWAP 219
PPP ++ F PP ++ + + + S PY + D WAP
Sbjct: 367 PPPDDIPMFDDSPPPPPPPPVDYEDEEAAVVQYS--------DPY------ADGDPAWAP 412
Query: 220 SQYICKVVTLYEYLQNKDDELSFQENELIYVVKKNNDGWWEGVMNGRTGLFPGNYVQNL 396
YI KVV +Y+Y ++KDDELSF+E +IYV+KKN+DGW+EGV N TGLFPGNYV+++
Sbjct: 413 KNYIEKVVAIYDYTKDKDDELSFKEGAIIYVIKKNDDGWFEGVCNRVTGLFPGNYVESI 471
>sp|Q9P2A4|ABI3_HUMAN ABI gene family member 3 (New molecule including SH3) (Nesh)
Length = 366
Score = 85.5 bits (210), Expect = 6e-17
Identities = 47/120 (39%), Positives = 66/120 (55%), Gaps = 6/120 (5%)
Frame = +1
Query: 49 PPPPNVEQFQRPPSNEQINIDKNQNRYISDSVGIAHLQPTPYDVLRIK------SQSDEV 210
PPP VE FQRPP+ E+++ + + + + P D L + +
Sbjct: 245 PPPAAVEVFQRPPTLEELS-PPPPDEELPLPLDLPPPPPLDGDELGLPPPPPGFGPDEPS 303
Query: 211 WAPSQYICKVVTLYEYLQNKDDELSFQENELIYVVKKNNDGWWEGVMNGRTGLFPGNYVQ 390
W P+ Y+ KVVTLY Y KD+ELSF E +I V ++ +DGW EGV + TG FPGNYV+
Sbjct: 304 WVPASYLEKVVTLYPYTSQKDNELSFSEGTVICVTRRYSDGWCEGVSSEGTGFFPGNYVE 363
>sp|Q8BYZ1|ABI3_MOUSE ABI gene family member 3 (New molecule including SH3) (Nesh)
Length = 367
Score = 79.7 bits (195), Expect = 3e-15
Identities = 43/115 (37%), Positives = 63/115 (54%)
Frame = +1
Query: 46 LPPPPNVEQFQRPPSNEQINIDKNQNRYISDSVGIAHLQPTPYDVLRIKSQSDEVWAPSQ 225
LPPPP + +PP ++ + D +G+ P + + W P+
Sbjct: 259 LPPPPL--EVSQPPLEAELPLPPPP-ALEGDELGLLPPPPPGF------GPDEPSWVPAS 309
Query: 226 YICKVVTLYEYLQNKDDELSFQENELIYVVKKNNDGWWEGVMNGRTGLFPGNYVQ 390
Y+ KVVTLY Y + KD+ELSF E +I V+++ +DGW EGV + TG FPGNYV+
Sbjct: 310 YLEKVVTLYPYTRQKDNELSFSEGTVICVIRRYSDGWCEGVSSEGTGFFPGNYVE 364
>sp|Q9NZM3|ITSN2_HUMAN Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18)
(SH3P18-like WASP associated protein)
Length = 1696
Score = 71.6 bits (174), Expect = 9e-13
Identities = 31/75 (41%), Positives = 50/75 (66%), Gaps = 1/75 (1%)
Frame = +1
Query: 169 PYDVLRIKSQSDEVWAPSQY-ICKVVTLYEYLQNKDDELSFQENELIYVVKKNNDGWWEG 345
P +++ S E P+ + +C+V+ +Y+Y N +DELSF + +LI V+ K++ WW+G
Sbjct: 1107 PASHVKLLGPSSERATPAFHPVCQVIAMYDYAANNEDELSFSKGQLINVMNKDDPDWWQG 1166
Query: 346 VMNGRTGLFPGNYVQ 390
+NG TGLFP NYV+
Sbjct: 1167 EINGVTGLFPSNYVK 1181
Score = 45.8 bits (107), Expect = 5e-05
Identities = 20/50 (40%), Positives = 31/50 (62%)
Frame = +1
Query: 241 VTLYEYLQNKDDELSFQENELIYVVKKNNDGWWEGVMNGRTGLFPGNYVQ 390
+ LY Y + +L+F E E I V +K+ + WW G + R+G+FP NYV+
Sbjct: 986 IALYPYSSVEPGDLTFTEGEEILVTQKDGE-WWTGSIGDRSGIFPSNYVK 1034
Score = 41.2 bits (95), Expect = 0.001
Identities = 18/52 (34%), Positives = 30/52 (57%), Gaps = 5/52 (9%)
Frame = +1
Query: 256 YLQNKDDELSFQENELIYVVKKNNDGWWEGVMNGR-----TGLFPGNYVQNL 396
Y+ + ++LS +LI ++KKN GWW+G + R G FP ++V+ L
Sbjct: 1063 YVASGSEQLSLAPGQLILILKKNTSGWWQGELQARGKKRQKGWFPASHVKLL 1114
Score = 38.9 bits (89), Expect = 0.006
Identities = 25/103 (24%), Positives = 43/103 (41%), Gaps = 2/103 (1%)
Frame = +1
Query: 94 EQINIDKNQNRYISDSVGIAHLQPTPYDVLRIKSQSDEVWAPSQYICKVVTLYEYLQNKD 273
+++ +K Q + + Q D L+ + + E + + LY +
Sbjct: 716 KRLQEEKTQEKIQEEERKAEEKQRKDKDTLKAEEKKRET---ASVLVNYRALYPFEARNH 772
Query: 274 DELSFQENELIYVVKKN--NDGWWEGVMNGRTGLFPGNYVQNL 396
DE+SF ++I V +K GW G G G FP NYV+ +
Sbjct: 773 DEMSFNSGDIIQVDEKTVGEPGWLYGSFQGNFGWFPCNYVEKM 815
Score = 38.9 bits (89), Expect = 0.006
Identities = 17/52 (32%), Positives = 32/52 (61%)
Frame = +1
Query: 235 KVVTLYEYLQNKDDELSFQENELIYVVKKNNDGWWEGVMNGRTGLFPGNYVQ 390
K L + KD+ L+F ++++I V+++ + WW G ++G G FP +YV+
Sbjct: 901 KAQALCSWTAKKDNHLNFSKHDIITVLEQQ-ENWWFGEVHGGRGWFPKSYVK 951
>sp|Q9Z0R6|ITSN2_MOUSE Intersectin-2 (SH3 domain-containing protein 1B) (EH and SH3 domains
protein 2) (EH domain and SH3 domain regulator of
endocytosis 2)
Length = 1658
Score = 71.2 bits (173), Expect = 1e-12
Identities = 30/75 (40%), Positives = 50/75 (66%), Gaps = 1/75 (1%)
Frame = +1
Query: 169 PYDVLRIKSQSDEVWAPSQY-ICKVVTLYEYLQNKDDELSFQENELIYVVKKNNDGWWEG 345
P +++ S E P+ + +C+V+ +Y+Y+ N +DEL+F + +LI V+ K++ WW+G
Sbjct: 1068 PASHVKLLGPSSERTMPTFHAVCQVIAMYDYMANNEDELNFSKGQLINVMNKDDPDWWQG 1127
Query: 346 VMNGRTGLFPGNYVQ 390
NG TGLFP NYV+
Sbjct: 1128 ETNGLTGLFPSNYVK 1142
Score = 47.4 bits (111), Expect = 2e-05
Identities = 21/50 (42%), Positives = 31/50 (62%)
Frame = +1
Query: 241 VTLYEYLQNKDDELSFQENELIYVVKKNNDGWWEGVMNGRTGLFPGNYVQ 390
+ LY Y + +L+F E E I V +K+ + WW G + RTG+FP NYV+
Sbjct: 947 IALYSYSSVEPGDLTFTEGEEILVTQKDGE-WWTGSIGERTGIFPSNYVR 995
Score = 40.0 bits (92), Expect = 0.003
Identities = 18/52 (34%), Positives = 29/52 (55%), Gaps = 5/52 (9%)
Frame = +1
Query: 256 YLQNKDDELSFQENELIYVVKKNNDGWWEGVMNGR-----TGLFPGNYVQNL 396
Y + ++LS +LI ++KKN GWW+G + R G FP ++V+ L
Sbjct: 1024 YAASGTEQLSLAPGQLILILKKNTSGWWQGELQARGKKRQKGWFPASHVKLL 1075
Score = 38.5 bits (88), Expect = 0.008
Identities = 19/52 (36%), Positives = 27/52 (51%), Gaps = 2/52 (3%)
Frame = +1
Query: 247 LYEYLQNKDDELSFQENELIYVVKKN--NDGWWEGVMNGRTGLFPGNYVQNL 396
LY + DE+SF ++I V +K GW G G+ G FP NYV+ +
Sbjct: 725 LYPFEARNHDEMSFSSGDIIQVDEKTVGEPGWLYGSFQGKFGWFPCNYVEKV 776
Score = 37.0 bits (84), Expect = 0.024
Identities = 16/52 (30%), Positives = 32/52 (61%)
Frame = +1
Query: 235 KVVTLYEYLQNKDDELSFQENELIYVVKKNNDGWWEGVMNGRTGLFPGNYVQ 390
K L + K++ L+F ++++I V+++ + WW G ++G G FP +YV+
Sbjct: 855 KAQALCSWTAKKENHLNFSKHDVITVLEQQ-ENWWFGEVHGGRGWFPKSYVK 905
>sp|Q15811|ITSN1_HUMAN Intersectin 1 (SH3 domain-containing protein 1A) (SH3P17)
Length = 1721
Score = 66.2 bits (160), Expect = 4e-11
Identities = 24/54 (44%), Positives = 39/54 (72%)
Frame = +1
Query: 229 ICKVVTLYEYLQNKDDELSFQENELIYVVKKNNDGWWEGVMNGRTGLFPGNYVQ 390
+C+V+ +Y+Y DDEL+F + ++I V+ K + WW+G +NG+ GLFP NYV+
Sbjct: 1157 VCQVIGMYDYTAQNDDELAFNKGQIINVLNKEDPDWWKGEVNGQVGLFPSNYVK 1210
Score = 50.1 bits (118), Expect = 3e-06
Identities = 19/50 (38%), Positives = 33/50 (66%)
Frame = +1
Query: 241 VTLYEYLQNKDDELSFQENELIYVVKKNNDGWWEGVMNGRTGLFPGNYVQ 390
+ +Y Y ++ +L+FQ+ ++I V KK+ D WW G + + G+FP NYV+
Sbjct: 1008 IAMYTYESSEQGDLTFQQGDVILVTKKDGD-WWTGTVGDKAGVFPSNYVR 1056
Score = 43.1 bits (100), Expect = 3e-04
Identities = 19/48 (39%), Positives = 32/48 (66%)
Frame = +1
Query: 247 LYEYLQNKDDELSFQENELIYVVKKNNDGWWEGVMNGRTGLFPGNYVQ 390
LY + KD+ L+F +N++I V+++ D WW G + G+ G FP +YV+
Sbjct: 921 LYPWRAKKDNHLNFNKNDVITVLEQQ-DMWWFGEVQGQKGWFPKSYVK 967
Score = 41.2 bits (95), Expect = 0.001
Identities = 20/53 (37%), Positives = 28/53 (52%), Gaps = 5/53 (9%)
Frame = +1
Query: 256 YLQNKDDELSFQENELIYVVKKNNDGWWEGVMNGR-----TGLFPGNYVQNLN 399
Y ++L+ +LI + KKN GWWEG + R G FP NYV+ L+
Sbjct: 1085 YTATGPEQLTLAPGQLILIRKKNPGGWWEGELQARGKKRQIGWFPANYVKLLS 1137
Score = 36.2 bits (82), Expect = 0.041
Identities = 16/57 (28%), Positives = 27/57 (47%), Gaps = 7/57 (12%)
Frame = +1
Query: 247 LYEYLQNKDDELSFQENELIYVV-------KKNNDGWWEGVMNGRTGLFPGNYVQNL 396
LY + DE++ Q +++ V + GW G + G+TG FP NY + +
Sbjct: 748 LYPFESRSHDEITIQPGDIVMVKGEWVDESQTGEPGWLGGELKGKTGWFPANYAEKI 804
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 48,179,058
Number of Sequences: 369166
Number of extensions: 947022
Number of successful extensions: 3328
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 3053
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 3227
length of database: 68,354,980
effective HSP length: 102
effective length of database: 49,512,010
effective search space used: 2921208590
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)