Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_027_M22
(861 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q9UII4|HERC5_HUMAN HECT domain and RCC1-like domain prot... 64 7e-10
sp|Q15034|HERC3_HUMAN HECT domain and RCC1-like domain prot... 61 4e-09
sp|Q8BK67|RCC2_MOUSE RCC2 protein 60 8e-09
sp|Q9P258|RCC2_HUMAN RCC2 protein (Telophase disk protein o... 59 2e-08
sp|Q91ZR4|NEK8_MOUSE Serine/threonine-protein kinase Nek8 (... 59 2e-08
sp|Q52KW8|RCC2_XENLA RCC2 protein homolog 59 2e-08
sp|Q86SG6|NEK8_HUMAN Serine/threonine-protein kinase Nek8 (... 57 5e-08
sp|Q6NYE2|RCC2_BRARE RCC2 protein homolog 57 9e-08
sp|Q90XC2|NEK8_BRARE Serine/threonine-protein kinase Nek8 (... 54 6e-07
sp|Q9N1T2|RPGR_CANFA X-linked retinitis pigmentosa GTPase r... 52 2e-06
>sp|Q9UII4|HERC5_HUMAN HECT domain and RCC1-like domain protein 5 (Cyclin-E binding
protein 1)
Length = 1024
Score = 63.5 bits (153), Expect = 7e-10
Identities = 33/81 (40%), Positives = 51/81 (62%), Gaps = 4/81 (4%)
Frame = +2
Query: 8 LNRKKIIDVACGSLHCICCTEDGEVYSWGDNDEGQLGDG----TTTTNSRPRIIETLTGK 175
L KKII + CG H + ++ GE+++WG N GQLG G +TTT P+I+E L G
Sbjct: 135 LQEKKIIQITCGDYHSLALSKGGELFAWGQNLHGQLGVGRKFPSTTT---PQIVEHLAGV 191
Query: 176 GINRVACGSAHTLAWTTVSGN 238
+ +++ G AH++A ++SGN
Sbjct: 192 PLAQISAGEAHSMA-LSMSGN 211
Score = 60.8 bits (146), Expect = 5e-09
Identities = 28/76 (36%), Positives = 44/76 (57%)
Frame = +2
Query: 8 LNRKKIIDVACGSLHCICCTEDGEVYSWGDNDEGQLGDGTTTTNSRPRIIETLTGKGINR 187
L+ +K+ VACG H T+DG ++++G GQLG +T RP ++ L G + +
Sbjct: 240 LDNQKVEFVACGGSHSALLTQDGLLFTFGAGKHGQLGHNSTQNELRPCLVAELVGYRVTQ 299
Query: 188 VACGSAHTLAWTTVSG 235
+ACG HTLA+ + G
Sbjct: 300 IACGRWHTLAYVSDLG 315
Score = 55.1 bits (131), Expect = 3e-07
Identities = 24/67 (35%), Positives = 37/67 (55%)
Frame = +2
Query: 23 IIDVACGSLHCICCTEDGEVYSWGDNDEGQLGDGTTTTNSRPRIIETLTGKGINRVACGS 202
+ ++ G H + + G +YSWG N+ GQLG G T + P +IE L + + VACG
Sbjct: 193 LAQISAGEAHSMALSMSGNIYSWGKNECGQLGLGHTESKDDPSLIEGLDNQKVEFVACGG 252
Query: 203 AHTLAWT 223
+H+ T
Sbjct: 253 SHSALLT 259
Score = 37.7 bits (86), Expect = 0.041
Identities = 18/50 (36%), Positives = 28/50 (56%), Gaps = 1/50 (2%)
Frame = +2
Query: 2 AQLNRKKIIDVACGSLHCICCTED-GEVYSWGDNDEGQLGDGTTTTNSRP 148
A+L ++ +ACG H + D G+V+S+G +GQLG+G T P
Sbjct: 290 AELVGYRVTQIACGRWHTLAYVSDLGKVFSFGSGKDGQLGNGGTRDQLMP 339
>sp|Q15034|HERC3_HUMAN HECT domain and RCC1-like domain protein 3
Length = 1050
Score = 61.2 bits (147), Expect = 4e-09
Identities = 27/72 (37%), Positives = 45/72 (62%), Gaps = 1/72 (1%)
Frame = +2
Query: 5 QLNRKKIIDVACGSLHCICCTEDGEVYSWGDNDEGQLGDGTT-TTNSRPRIIETLTGKGI 181
+LN++ I+ V+CG+ HC+ DG+ ++WG N GQLG G + + P+ + +L G +
Sbjct: 133 KLNQQTILQVSCGNWHCLALAADGQFFTWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPL 192
Query: 182 NRVACGSAHTLA 217
+VA G AH+ A
Sbjct: 193 AQVAAGGAHSFA 204
Score = 57.0 bits (136), Expect = 7e-08
Identities = 36/102 (35%), Positives = 52/102 (50%), Gaps = 11/102 (10%)
Frame = +2
Query: 23 IIDVACGSLHCICCTEDGEVYSWGDNDEGQLGDGTTTTN-SRPRIIETLTGKGINRVACG 199
II VACG H + ++ G+++SWG +GQLG TT + + PR+I+ L + I +V+CG
Sbjct: 86 IIHVACGESHSLALSDRGQLFSWGAGSDGQLGLMTTEDSVAVPRLIQKLNQQTILQVSCG 145
Query: 200 SAHTLAWTT-----VSGNKSH-----ETESPEQRLPMSTRPI 295
+ H LA G SH E P Q P R +
Sbjct: 146 NWHCLALAADGQFFTWGKNSHGQLGLGKEFPSQASPQRVRSL 187
Score = 56.6 bits (135), Expect = 9e-08
Identities = 26/76 (34%), Positives = 41/76 (53%)
Frame = +2
Query: 8 LNRKKIIDVACGSLHCICCTEDGEVYSWGDNDEGQLGDGTTTTNSRPRIIETLTGKGINR 187
L +K++ ++CG H T+ G V+++G GQLG + PR + L G + +
Sbjct: 239 LRTQKVVYISCGEEHTAVLTKSGGVFTFGAGSCGQLGHDSMNDEVNPRRVLELMGSEVTQ 298
Query: 188 VACGSAHTLAWTTVSG 235
+ACG HTLA+ SG
Sbjct: 299 IACGRQHTLAFVPSSG 314
Score = 53.9 bits (128), Expect = 6e-07
Identities = 28/70 (40%), Positives = 41/70 (58%)
Frame = +2
Query: 8 LNRKKIIDVACGSLHCICCTEDGEVYSWGDNDEGQLGDGTTTTNSRPRIIETLTGKGINR 187
++ + + +VACG H + EDGEVY+ G N +GQLG ++P I L + I
Sbjct: 31 ISDRSVKEVACGGNHSVFLLEDGEVYTCGLNTKGQLGH--EREGNKPEQIGALADQHIIH 88
Query: 188 VACGSAHTLA 217
VACG +H+LA
Sbjct: 89 VACGESHSLA 98
Score = 43.1 bits (100), Expect = 0.001
Identities = 21/71 (29%), Positives = 31/71 (43%)
Frame = +2
Query: 23 IIDVACGSLHCICCTEDGEVYSWGDNDEGQLGDGTTTTNSRPRIIETLTGKGINRVACGS 202
+ VA G H + G V+ WG N+ GQLG P ++ L + + ++CG
Sbjct: 192 LAQVAAGGAHSFALSLSGAVFGWGMNNAGQLGLSDEKDRESPCHVKLLRTQKVVYISCGE 251
Query: 203 AHTLAWTTVSG 235
HT T G
Sbjct: 252 EHTAVLTKSGG 262
>sp|Q8BK67|RCC2_MOUSE RCC2 protein
Length = 520
Score = 60.1 bits (144), Expect = 8e-09
Identities = 28/69 (40%), Positives = 43/69 (62%)
Frame = +2
Query: 17 KKIIDVACGSLHCICCTEDGEVYSWGDNDEGQLGDGTTTTNSRPRIIETLTGKGINRVAC 196
+ ++ +C + H + T +G+++SWG N++GQLG G T PR+IE L+ + I AC
Sbjct: 149 RTVVSGSCAA-HSLLITTEGKLWSWGRNEKGQLGHGDTKRVEAPRLIEALSHEAIVLAAC 207
Query: 197 GSAHTLAWT 223
G HTLA T
Sbjct: 208 GRNHTLALT 216
Score = 44.7 bits (104), Expect = 3e-04
Identities = 22/69 (31%), Positives = 37/69 (53%)
Frame = +2
Query: 8 LNRKKIIDVACGSLHCICCTEDGEVYSWGDNDEGQLGDGTTTTNSRPRIIETLTGKGINR 187
L+ + I+ ACG H + T+ G V+++G+N GQLG G T G+ I +
Sbjct: 197 LSHEAIVLAACGRNHTLALTDTGSVFAFGENKMGQLGLGNQTDAVPSPAQIMYNGQPITK 256
Query: 188 VACGSAHTL 214
+ACG+ ++
Sbjct: 257 MACGAEFSM 265
Score = 40.0 bits (92), Expect = 0.008
Identities = 21/71 (29%), Positives = 33/71 (46%), Gaps = 2/71 (2%)
Frame = +2
Query: 29 DVACGSLHCICCTEDGEVYSWGDNDEGQLGDGTTTTNSRPRIIE--TLTGKGINRVACGS 202
DVACG+ H + V+SWG G+LG PR+++ G+G ++ G
Sbjct: 332 DVACGANHTLVLDSQKRVFSWGFGGYGRLGHAEQKDEMVPRLVKLFDFPGRGATQIYAGY 391
Query: 203 AHTLAWTTVSG 235
+ A + V G
Sbjct: 392 TCSFAVSEVGG 402
>sp|Q9P258|RCC2_HUMAN RCC2 protein (Telophase disk protein of 60 kDa) (RCC1-like protein
TD-60)
Length = 522
Score = 58.5 bits (140), Expect = 2e-08
Identities = 28/69 (40%), Positives = 43/69 (62%)
Frame = +2
Query: 17 KKIIDVACGSLHCICCTEDGEVYSWGDNDEGQLGDGTTTTNSRPRIIETLTGKGINRVAC 196
+ ++ +C + H + T +G+++SWG N++GQLG G T PR+IE L+ + I AC
Sbjct: 151 RTVVSGSCAA-HSLLITTEGKLWSWGRNEKGQLGHGDTKRVEAPRLIEGLSHEVIVSAAC 209
Query: 197 GSAHTLAWT 223
G HTLA T
Sbjct: 210 GRNHTLALT 218
Score = 47.0 bits (110), Expect = 7e-05
Identities = 23/69 (33%), Positives = 37/69 (53%)
Frame = +2
Query: 8 LNRKKIIDVACGSLHCICCTEDGEVYSWGDNDEGQLGDGTTTTNSRPRIIETLTGKGINR 187
L+ + I+ ACG H + TE G V+++G+N GQLG G T G+ I +
Sbjct: 199 LSHEVIVSAACGRNHTLALTETGSVFAFGENKMGQLGLGNQTDAVPSPAQIMYNGQPITK 258
Query: 188 VACGSAHTL 214
+ACG+ ++
Sbjct: 259 MACGAEFSM 267
Score = 40.4 bits (93), Expect = 0.006
Identities = 21/71 (29%), Positives = 34/71 (47%), Gaps = 2/71 (2%)
Frame = +2
Query: 29 DVACGSLHCICCTEDGEVYSWGDNDEGQLGDGTTTTNSRPRIIE--TLTGKGINRVACGS 202
DVACG+ H + V+SWG G+LG PR+++ G+G +++ G
Sbjct: 334 DVACGANHTLVLDSQKRVFSWGFGGYGRLGHAEQKDEMVPRLVKLFDFPGRGASQIYAGY 393
Query: 203 AHTLAWTTVSG 235
+ A + V G
Sbjct: 394 TCSFAVSEVGG 404
>sp|Q91ZR4|NEK8_MOUSE Serine/threonine-protein kinase Nek8 (NimA-related protein kinase
8)
Length = 698
Score = 58.5 bits (140), Expect = 2e-08
Identities = 28/65 (43%), Positives = 39/65 (60%)
Frame = +2
Query: 32 VACGSLHCICCTEDGEVYSWGDNDEGQLGDGTTTTNSRPRIIETLTGKGINRVACGSAHT 211
VACG L C T+ G + ++G G LG G T S+P I+E L G + +VACG++H
Sbjct: 402 VACGDLFTACLTDRGIIMTFGSGSNGCLGHGNLTDISQPTIVEALLGYEMVQVACGASHV 461
Query: 212 LAWTT 226
LA +T
Sbjct: 462 LALST 466
Score = 55.5 bits (132), Expect = 2e-07
Identities = 23/69 (33%), Positives = 42/69 (60%)
Frame = +2
Query: 20 KIIDVACGSLHCICCTEDGEVYSWGDNDEGQLGDGTTTTNSRPRIIETLTGKGINRVACG 199
+++ VACG+ H + + DGE+++WG D G+LG GT +++ P+ + G+ RV CG
Sbjct: 450 EMVQVACGASHVLALSTDGELFAWGRGDGGRLGLGTRESHNCPQQVPVAPGQEAQRVVCG 509
Query: 200 SAHTLAWTT 226
++ T+
Sbjct: 510 IDSSMILTS 518
Score = 48.1 bits (113), Expect = 3e-05
Identities = 24/72 (33%), Positives = 39/72 (54%)
Frame = +2
Query: 2 AQLNRKKIIDVACGSLHCICCTEDGEVYSWGDNDEGQLGDGTTTTNSRPRIIETLTGKGI 181
A L+++ ++ V G+ H T G+ Y++G N GQLG + + P ++ L G +
Sbjct: 562 APLDQEPLLCVDLGTAHSAAITASGDCYTFGSNQHGQLGTSSRRVSRAPCRVQGLEGIKM 621
Query: 182 NRVACGSAHTLA 217
VACG A T+A
Sbjct: 622 VMVACGDAFTVA 633
Score = 37.7 bits (86), Expect = 0.041
Identities = 21/66 (31%), Positives = 31/66 (46%), Gaps = 1/66 (1%)
Frame = +2
Query: 20 KIIDVACGSLHCICCTEDGEVYSWGDNDEGQLGDGTTTTN-SRPRIIETLTGKGINRVAC 196
K++ VACG + +GEVYSWG G+LG RP ++ + V+C
Sbjct: 620 KMVMVACGDAFTVAVGAEGEVYSWGKGTRGRLGRRDEDAGLPRPVQLDETHPYMVTSVSC 679
Query: 197 GSAHTL 214
+TL
Sbjct: 680 CHGNTL 685
>sp|Q52KW8|RCC2_XENLA RCC2 protein homolog
Length = 513
Score = 58.5 bits (140), Expect = 2e-08
Identities = 37/102 (36%), Positives = 50/102 (49%), Gaps = 17/102 (16%)
Frame = +2
Query: 20 KIIDVACGSL--HCICCTEDGEVYSWGDNDEGQLGDGTTTTNSRPRIIETLTGKGINRVA 193
++ VA GS H + T +G+++SWG ND+GQLG G P++IE+L G+ A
Sbjct: 140 QVRSVASGSCAAHSLLITVEGKLWSWGRNDKGQLGHGDIKRIDVPKLIESLKGEVFVHAA 199
Query: 194 CGSAHTLAWTTVS---------------GNKSHETESPEQRL 274
CG HTLA T GNK+ SP Q L
Sbjct: 200 CGRNHTLALTENGSVYAFGENKMGQLGLGNKTDAVPSPAQIL 241
Score = 47.8 bits (112), Expect = 4e-05
Identities = 26/70 (37%), Positives = 41/70 (58%), Gaps = 1/70 (1%)
Frame = +2
Query: 8 LNRKKIIDVACGSLHCICCTEDGEVYSWGDNDEGQLGDGTTTTNSRPRIIETL-TGKGIN 184
L + + ACG H + TE+G VY++G+N GQLG G T++ P + L G+ I
Sbjct: 190 LKGEVFVHAACGRNHTLALTENGSVYAFGENKMGQLGLG-NKTDAVPSPAQILYNGQPIT 248
Query: 185 RVACGSAHTL 214
+VACG+ ++
Sbjct: 249 KVACGAEFSM 258
Score = 37.7 bits (86), Expect = 0.041
Identities = 19/71 (26%), Positives = 33/71 (46%), Gaps = 2/71 (2%)
Frame = +2
Query: 29 DVACGSLHCICCTEDGEVYSWGDNDEGQLGDGTTTTNSRPRIIE--TLTGKGINRVACGS 202
D+ACG H + V+SWG G+LG PR+++ G+G ++ G+
Sbjct: 325 DIACGINHSLILDSQKRVFSWGFGGYGRLGHSEQRDEMVPRLVKLFDFPGRGAAQIYAGA 384
Query: 203 AHTLAWTTVSG 235
+ A + + G
Sbjct: 385 TCSFAVSEMGG 395
Score = 33.9 bits (76), Expect = 0.60
Identities = 23/89 (25%), Positives = 48/89 (53%), Gaps = 3/89 (3%)
Frame = +2
Query: 20 KIIDVACGSLHCICCTEDGEVYSWGDNDE-GQLG--DGTTTTNSRPRIIETLTGKGINRV 190
K+ +ACG I ++ + SWG + G+LG D +++ + ++TL G ++V
Sbjct: 422 KVRSLACGKSSIIVAADESTI-SWGPSPTFGELGYGDNKAKSSTTAQEVKTLDGIYSDQV 480
Query: 191 ACGSAHTLAWTTVSGNKSHETESPEQRLP 277
G++HTL V+ +++ + + ++LP
Sbjct: 481 IMGNSHTL---VVARDETEQDKEKLKKLP 506
>sp|Q86SG6|NEK8_HUMAN Serine/threonine-protein kinase Nek8 (NimA-related protein kinase
8) (NIMA-related kinase 12a)
Length = 692
Score = 57.4 bits (137), Expect = 5e-08
Identities = 27/65 (41%), Positives = 39/65 (60%)
Frame = +2
Query: 32 VACGSLHCICCTEDGEVYSWGDNDEGQLGDGTTTTNSRPRIIETLTGKGINRVACGSAHT 211
VACG C T+ G + ++G G LG G+ T S+P I+E L G + +VACG++H
Sbjct: 396 VACGDFFTACLTDRGIIMTFGSGSNGCLGHGSLTDISQPTIVEALLGYEMVQVACGASHV 455
Query: 212 LAWTT 226
LA +T
Sbjct: 456 LALST 460
Score = 51.2 bits (121), Expect = 4e-06
Identities = 21/60 (35%), Positives = 37/60 (61%)
Frame = +2
Query: 20 KIIDVACGSLHCICCTEDGEVYSWGDNDEGQLGDGTTTTNSRPRIIETLTGKGINRVACG 199
+++ VACG+ H + + + E+++WG D G+LG GT ++S P+ + G+ RV CG
Sbjct: 444 EMVQVACGASHVLALSTERELFAWGRGDSGRLGLGTRESHSCPQQVPMPPGQEAQRVVCG 503
Score = 50.1 bits (118), Expect = 8e-06
Identities = 24/72 (33%), Positives = 39/72 (54%)
Frame = +2
Query: 2 AQLNRKKIIDVACGSLHCICCTEDGEVYSWGDNDEGQLGDGTTTTNSRPRIIETLTGKGI 181
A L+++ ++ + G+ H T G+ Y++G N GQLG T + P ++ L G +
Sbjct: 556 APLDQEPLLSIDLGTAHSAAVTASGDCYTFGSNQHGQLGTNTRRGSRAPCKVQGLEGIKM 615
Query: 182 NRVACGSAHTLA 217
VACG A T+A
Sbjct: 616 AMVACGDAFTVA 627
Score = 33.9 bits (76), Expect = 0.60
Identities = 20/66 (30%), Positives = 29/66 (43%), Gaps = 1/66 (1%)
Frame = +2
Query: 20 KIIDVACGSLHCICCTEDGEVYSWGDNDEGQLGDGTTTTN-SRPRIIETLTGKGINRVAC 196
K+ VACG + + EVYSWG G+LG RP ++ + V+C
Sbjct: 614 KMAMVACGDAFTVAIGAESEVYSWGKGARGRLGRRDEDAGLPRPVQLDETHPYTVTSVSC 673
Query: 197 GSAHTL 214
+TL
Sbjct: 674 CHGNTL 679
>sp|Q6NYE2|RCC2_BRARE RCC2 protein homolog
Length = 495
Score = 56.6 bits (135), Expect = 9e-08
Identities = 27/58 (46%), Positives = 36/58 (62%)
Frame = +2
Query: 50 HCICCTEDGEVYSWGDNDEGQLGDGTTTTNSRPRIIETLTGKGINRVACGSAHTLAWT 223
H + T +G+++SWG ND+GQLG G T P++IE L + I ACG HTLA T
Sbjct: 134 HSLIITTEGKLWSWGRNDKGQLGHGDTKRLEAPKLIEGLGEEVIVAAACGRNHTLALT 191
Score = 49.7 bits (117), Expect = 1e-05
Identities = 25/69 (36%), Positives = 37/69 (53%)
Frame = +2
Query: 8 LNRKKIIDVACGSLHCICCTEDGEVYSWGDNDEGQLGDGTTTTNSRPRIIETLTGKGINR 187
L + I+ ACG H + TE+G VY++G+N GQLG G T G+ I +
Sbjct: 172 LGEEVIVAAACGRNHTLALTENGTVYTFGENKLGQLGQGNQTDAVLSPATIQYNGQPIVK 231
Query: 188 VACGSAHTL 214
VACG+ ++
Sbjct: 232 VACGAEFSM 240
Score = 42.4 bits (98), Expect = 0.002
Identities = 21/71 (29%), Positives = 34/71 (47%), Gaps = 2/71 (2%)
Frame = +2
Query: 29 DVACGSLHCICCTEDGEVYSWGDNDEGQLGDGTTTTNSRPRIIE--TLTGKGINRVACGS 202
DVACG+ H + V+SWG G+LG PR+++ G+G ++ CG
Sbjct: 307 DVACGANHTLVLDSQKRVFSWGFGGYGRLGHAEQKDEMVPRLVKLFDFPGRGATQIYCGY 366
Query: 203 AHTLAWTTVSG 235
+ A + + G
Sbjct: 367 QCSFALSEMGG 377
Score = 31.6 bits (70), Expect = 3.0
Identities = 21/68 (30%), Positives = 35/68 (51%), Gaps = 3/68 (4%)
Frame = +2
Query: 20 KIIDVACGSLHCICCTEDGEVYSWGDNDE-GQL--GDGTTTTNSRPRIIETLTGKGINRV 190
KI +ACG I +D + SWG + G+L GD +++ + ++TL G +V
Sbjct: 404 KIRSLACGKSSIIVAADDSTI-SWGPSPTFGELGYGDNKPKSSTTAQEVKTLDGVYSEQV 462
Query: 191 ACGSAHTL 214
G +H+L
Sbjct: 463 VMGYSHSL 470
Score = 30.8 bits (68), Expect = 5.1
Identities = 29/94 (30%), Positives = 42/94 (44%), Gaps = 24/94 (25%)
Frame = +2
Query: 5 QLNRKKIIDVACGSLHCICCTEDGEVYSWGDNDEGQLG---DGTTTTNSR---------P 148
Q N + I+ VACG+ + G +YS+G + GQLG DG ++ P
Sbjct: 223 QYNGQPIVKVACGAEFSMIVDCKGNLYSFGCPEYGQLGHNSDGKFIARAQRIEFDCELIP 282
Query: 149 R-----IIETLTGKGI-------NRVACGSAHTL 214
R I +T G+ + VACG+ HTL
Sbjct: 283 RRVAIFIEKTKDGQVLPVPNVVARDVACGANHTL 316
>sp|Q90XC2|NEK8_BRARE Serine/threonine-protein kinase Nek8 (NimA-related protein kinase
8)
Length = 697
Score = 53.9 bits (128), Expect = 6e-07
Identities = 25/67 (37%), Positives = 39/67 (58%)
Frame = +2
Query: 23 IIDVACGSLHCICCTEDGEVYSWGDNDEGQLGDGTTTTNSRPRIIETLTGKGINRVACGS 202
I V+CG L C T+ G + ++G G LG G ++P+I+E L G + +V+CG+
Sbjct: 400 IKSVSCGDLFTTCLTDRGIIMTFGSGSNGCLGHGNFNDVTQPKIVEALLGYELVQVSCGA 459
Query: 203 AHTLAWT 223
+H LA T
Sbjct: 460 SHVLAVT 466
Score = 51.2 bits (121), Expect = 4e-06
Identities = 27/72 (37%), Positives = 40/72 (55%)
Frame = +2
Query: 2 AQLNRKKIIDVACGSLHCICCTEDGEVYSWGDNDEGQLGDGTTTTNSRPRIIETLTGKGI 181
A LN +KI+ + G+ H + TE G+ +++G N GQLG ++ P + L +GI
Sbjct: 563 APLNTEKIVYIDIGTAHSVAVTEKGQCFTFGSNQHGQLGCSHRRSSRVPYQVSGL--QGI 620
Query: 182 NRVACGSAHTLA 217
ACG A TLA
Sbjct: 621 TMAACGDAFTLA 632
Score = 47.4 bits (111), Expect = 5e-05
Identities = 20/60 (33%), Positives = 34/60 (56%)
Frame = +2
Query: 20 KIIDVACGSLHCICCTEDGEVYSWGDNDEGQLGDGTTTTNSRPRIIETLTGKGINRVACG 199
+++ V+CG+ H + T + EV+SWG D G+LG T +++ P+ + RV CG
Sbjct: 451 ELVQVSCGASHVLAVTNEREVFSWGRGDNGRLGLATQDSHNCPQQVSLPADFEAQRVLCG 510
Score = 31.6 bits (70), Expect = 3.0
Identities = 12/28 (42%), Positives = 16/28 (57%)
Frame = +2
Query: 35 ACGSLHCICCTEDGEVYSWGDNDEGQLG 118
ACG + +GEVY+WG G+LG
Sbjct: 624 ACGDAFTLAIGAEGEVYTWGKGARGRLG 651
>sp|Q9N1T2|RPGR_CANFA X-linked retinitis pigmentosa GTPase regulator
Length = 1003
Score = 52.4 bits (124), Expect = 2e-06
Identities = 27/72 (37%), Positives = 41/72 (56%)
Frame = +2
Query: 11 NRKKIIDVACGSLHCICCTEDGEVYSWGDNDEGQLGDGTTTTNSRPRIIETLTGKGINRV 190
+++KI ++ GS TEDGE++ WGDN EGQ+G T P+ + GK I+ +
Sbjct: 138 SQRKIKQLSAGSNTSAALTEDGELFMWGDNSEGQIGLENVTNVCVPQ--QVTVGKPISWI 195
Query: 191 ACGSAHTLAWTT 226
+CG H+ TT
Sbjct: 196 SCGYYHSAFVTT 207
Score = 49.7 bits (117), Expect = 1e-05
Identities = 23/64 (35%), Positives = 37/64 (57%)
Frame = +2
Query: 32 VACGSLHCICCTEDGEVYSWGDNDEGQLGDGTTTTNSRPRIIETLTGKGINRVACGSAHT 211
++CG H T + ++Y +G N+ GQLG G+ +T S+P ++ L + + ACG HT
Sbjct: 40 LSCGDEHTAVVTGNNKLYMFGSNNWGQLGLGSKSTVSKPTCVKALKPEKVKFAACGRNHT 99
Query: 212 LAWT 223
L T
Sbjct: 100 LVST 103
Score = 47.0 bits (110), Expect = 7e-05
Identities = 28/73 (38%), Positives = 40/73 (54%), Gaps = 1/73 (1%)
Frame = +2
Query: 8 LNRKKIIDVACGSLHCICCTEDGEVYSWGDNDEGQLGDGTTTTNSRPRIIETLTG-KGIN 184
L +K+ ACG H + TE G+VY+ G N+EGQLG G T S +I T + I
Sbjct: 84 LKPEKVKFAACGRNHTLVSTEGGKVYAAGGNNEGQLGLGDTEERSTFHLISFFTSQRKIK 143
Query: 185 RVACGSAHTLAWT 223
+++ GS + A T
Sbjct: 144 QLSAGSNTSAALT 156
Score = 46.6 bits (109), Expect = 9e-05
Identities = 27/65 (41%), Positives = 37/65 (56%), Gaps = 1/65 (1%)
Frame = +2
Query: 20 KIIDVACGSLHCICCTEDGEVYSWGDNDEGQLGDGTTT-TNSRPRIIETLTGKGINRVAC 196
K++ VACG H + TE VY++G GQLG GT S P+ IE + + I+ +AC
Sbjct: 244 KVVQVACGGGHTVVLTEKA-VYTFGLGQFGQLGLGTFLFETSVPKAIEHIKDQKISFIAC 302
Query: 197 GSAHT 211
G HT
Sbjct: 303 GENHT 307
Score = 45.8 bits (107), Expect = 2e-04
Identities = 30/87 (34%), Positives = 42/87 (48%), Gaps = 4/87 (4%)
Frame = +2
Query: 17 KKIIDVACGSLHCICCTEDGEVYSWGDNDEGQLGDGTTTTNSRPRIIETLTGKG----IN 184
+KI +ACG H T+ G +Y++GD G+LG G NS + I TL +
Sbjct: 295 QKISFIACGENHTALITDMGLMYTFGDGRHGKLGLG--LENSTNQFIPTLCSNFLRFIVQ 352
Query: 185 RVACGSAHTLAWTTVSGNKSHETESPE 265
V+CG HTL + T + E E E
Sbjct: 353 LVSCGGCHTLVFATPRLGGTEEMELKE 379
Score = 41.2 bits (95), Expect = 0.004
Identities = 22/71 (30%), Positives = 40/71 (56%), Gaps = 2/71 (2%)
Frame = +2
Query: 17 KKIIDVACGSLHCICCTEDGEVYSWGDNDEGQLG--DGTTTTNSRPRIIETLTGKGINRV 190
K I ++CG H T +G++Y++G+ + G+LG + + P+ + + GK + +V
Sbjct: 190 KPISWISCGYYHSAFVTTEGQLYTFGEPECGKLGLPNQLLVNHRMPQPVPGIPGKVV-QV 248
Query: 191 ACGSAHTLAWT 223
ACG HT+ T
Sbjct: 249 ACGGGHTVVLT 259
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 99,914,070
Number of Sequences: 369166
Number of extensions: 2038719
Number of successful extensions: 5649
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 5280
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 5627
length of database: 68,354,980
effective HSP length: 109
effective length of database: 48,218,865
effective search space used: 8534739105
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)