Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_027_M19
(803 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q91XW8|FKBP6_MOUSE FK506-binding protein 6 (Peptidyl-pro... 102 9e-22
sp|O75344|FKBP6_HUMAN FK506-binding protein 6 (Peptidyl-pro... 99 2e-20
sp|Q38931|FKB70_ARATH 70 kDa peptidylprolyl isomerase (Pept... 65 2e-10
sp|Q43207|FKB70_WHEAT 70 kDa peptidylprolyl isomerase (Pept... 59 2e-08
sp|Q13451|FKBP5_HUMAN FK506-binding protein 5 (Peptidyl-pro... 55 3e-07
sp|Q64378|FKBP5_MOUSE FK506-binding protein 5 (Peptidyl-pro... 55 3e-07
sp|Q5RF88|FKBP5_PONPY FK506-binding protein 5 (Peptidyl-pro... 55 3e-07
sp|Q9XT11|FKBP5_AOTNA FK506-binding protein 5 (Peptidyl-pro... 54 4e-07
sp|Q9XSH5|FKBP5_SAIBB FK506-binding protein 5 (Peptidyl-pro... 54 5e-07
sp|Q9XSI2|FKBP5_SAGOE FK506-binding protein 5 (Peptidyl-pro... 52 1e-06
>sp|Q91XW8|FKBP6_MOUSE FK506-binding protein 6 (Peptidyl-prolyl cis-trans isomerase)
(PPIase) (Rotamase) (36 kDa FK506 binding protein)
(FKBP-36) (Immunophilin FKBP36)
Length = 327
Score = 102 bits (255), Expect = 9e-22
Identities = 59/182 (32%), Positives = 96/182 (52%)
Frame = +3
Query: 225 YKNIASKMTDISGGQKLIFKRLISKGEGSKAPEGSLVIYNYKFYCEPEPEPFDSTRFKKR 404
Y+ ++ +M DISG + ++ K +I +G G + V+ Y Y E +PFDS F+K
Sbjct: 22 YERLSQRMLDISGDRGVL-KDIIREGTGDTVTPDASVLVKYSGYLEHMDKPFDSNCFRKT 80
Query: 405 PDRQRVGVGQLLPGLDVALQSMSRKERAHFVFDSSVMFGELGVPPRIPERADIYAEIEVI 584
P ++G L G+++ L SM + E A F+F + +G LG PP IP A + EIE+I
Sbjct: 81 PRLMKLGEDITLWGMELGLLSMRKGELARFLFKPAYAYGTLGCPPLIPPNATVLFEIELI 140
Query: 585 DFTEKNLIDDFFEKTVEERLELSFSDMIKLVIQCRDDANVAVRDKRFGGALNKYQRGLDI 764
DF + D F + E++ + ++K+ R+ N R RF A +Y+R L +
Sbjct: 141 DFLDSAESDKFCALSAEQQEQFPLQKVLKVAATEREFGNYLFRQNRFCDAKVRYKRALLL 200
Query: 765 LY 770
L+
Sbjct: 201 LH 202
>sp|O75344|FKBP6_HUMAN FK506-binding protein 6 (Peptidyl-prolyl cis-trans isomerase)
(PPIase) (Rotamase) (36 kDa FK506 binding protein)
(FKBP-36) (Immunophilin FKBP36)
Length = 327
Score = 98.6 bits (244), Expect = 2e-20
Identities = 58/181 (32%), Positives = 93/181 (51%)
Frame = +3
Query: 225 YKNIASKMTDISGGQKLIFKRLISKGEGSKAPEGSLVIYNYKFYCEPEPEPFDSTRFKKR 404
Y+ ++ +M DISG + ++ K +I +G G + V+ Y Y E PFDS F+K
Sbjct: 22 YERLSQRMLDISGDRGVL-KDVIREGAGDLVAPDASVLVKYSGYLEHMDRPFDSNYFRKT 80
Query: 405 PDRQRVGVGQLLPGLDVALQSMSRKERAHFVFDSSVMFGELGVPPRIPERADIYAEIEVI 584
P ++G L G+++ L SM R E A F+F + +G LG PP IP + EIE++
Sbjct: 81 PRLMKLGEDITLWGMELGLLSMRRGELARFLFKPNYAYGTLGCPPLIPPNTTVLFEIELL 140
Query: 585 DFTEKNLIDDFFEKTVEERLELSFSDMIKLVIQCRDDANVAVRDKRFGGALNKYQRGLDI 764
DF + D F + E++ + ++K+ R+ N R RF A +Y+R L +
Sbjct: 141 DFLDCAESDKFCALSAEQQDQFPLQKVLKVAATEREFGNYLFRQNRFYDAKVRYKRALLL 200
Query: 765 L 767
L
Sbjct: 201 L 201
>sp|Q38931|FKB70_ARATH 70 kDa peptidylprolyl isomerase (Peptidyl-prolyl cis-trans
isomerase) (PPIase) (Rotamase) (Peptidylprolyl isomerase
ROF1)
Length = 551
Score = 65.1 bits (157), Expect = 2e-10
Identities = 37/130 (28%), Positives = 69/130 (53%)
Frame = +3
Query: 195 NDPDSVDFPSYKNIASKMTDISGGQKLIFKRLISKGEGSKAPEGSLVIYNYKFYCEPEPE 374
ND D +DF + K+ + Q+ + K+L+ +GEG + PE + + +
Sbjct: 14 NDDDDMDFGDGASFL-KVGEEKEIQQGLKKKLLKEGEGYETPENGDEVEVHYTGTLLDGT 72
Query: 375 PFDSTRFKKRPDRQRVGVGQLLPGLDVALQSMSRKERAHFVFDSSVMFGELGVPPRIPER 554
FDS+R + P + +G GQ++ G D+ +++M + E A F + + +GE G PP IP
Sbjct: 73 KFDSSRDRATPFKFTLGQGQVIKGWDIGIKTMKKGENAVFTIPAELAYGESGSPPTIPAN 132
Query: 555 ADIYAEIEVI 584
A + ++E++
Sbjct: 133 ATLQFDVELL 142
Score = 35.0 bits (79), Expect = 0.24
Identities = 44/218 (20%), Positives = 100/218 (45%), Gaps = 19/218 (8%)
Frame = +3
Query: 207 SVDFPSYKNIASKMTDISGGQKLIFKRLISKGEGSKAP-EGSLV------------IYNY 347
+++ S+K + S++TD + K+++ +G+G + P EG++V ++
Sbjct: 255 NLELVSWKTV-SEVTD----DNKVVKKVLKEGDGYERPNEGAVVKVKLIGKLQDGTVFLK 309
Query: 348 KFYCEPEPEPFDSTRFKKRPDRQRVGVGQLLPGLDVALQSMSRKERAHFVFDSSVMFG-- 521
K + E E EPF+ FK + Q++ GLD A+ M + E A D FG
Sbjct: 310 KGHGENE-EPFE---FKTDEE-------QVVDGLDRAVMKMKKGEVALVTIDPEYAFGSN 358
Query: 522 ----ELGVPPRIPERADIYAEIEVIDFTEKNLIDDFFEKTVEERLELSFSDMIKLVIQCR 689
EL V +P + + E++++ F ++ + ++ EE++E + +
Sbjct: 359 ESQQELAV---VPPNSTVTYEVDLLTFDKER---ESWDMNTEEKIEAASKK--------K 404
Query: 690 DDANVAVRDKRFGGALNKYQRGLDILYSMPICTDDEER 803
++ N + ++ A +Y++ + + +++E++
Sbjct: 405 EEGNSKFKGGKYSLASKRYEKAVKFIEYDTSFSEEEKK 442
>sp|Q43207|FKB70_WHEAT 70 kDa peptidylprolyl isomerase (Peptidyl-prolyl cis-trans
isomerase) (PPIase) (Rotamase)
Length = 559
Score = 58.9 bits (141), Expect = 2e-08
Identities = 35/128 (27%), Positives = 70/128 (54%), Gaps = 3/128 (2%)
Frame = +3
Query: 264 GQKLIFKRLISKGEGSKAPEGSLVIYNYKFYCEPEPEPFDSTRFKKRPDRQRVGVGQLLP 443
G++ + K+L+ +GEG PE + + + + FDS+R + + ++G GQ++
Sbjct: 39 GKQGLKKKLLKEGEGWDTPEVGDEVEVHYTGTLLDGKKFDSSRDRDDTFKFKLGQGQVIK 98
Query: 444 GLDVALQSMSRKERAHFVFDSSVMFGELGVPPRIPERADIYAEIEVIDFTE-KNLIDD-- 614
G D +++M + E A F + +GE G PP IP A + ++E++ +T +++ D
Sbjct: 99 GWDQGIKTMKKGENALFTIPPELAYGESGSPPTIPANATLQFDVELLSWTSVRDIAKDGG 158
Query: 615 FFEKTVEE 638
F+K ++E
Sbjct: 159 IFKKILKE 166
>sp|Q13451|FKBP5_HUMAN FK506-binding protein 5 (Peptidyl-prolyl cis-trans isomerase)
(PPIase) (Rotamase) (51 kDa FK506-binding protein)
(FKBP-51) (54 kDa progesterone receptor-associated
immunophilin) (FKBP54) (P54) (FF1 antigen)
(HSP90-binding immunophilin) (Androgen-regulated protein
6)
Length = 457
Score = 54.7 bits (130), Expect = 3e-07
Identities = 34/129 (26%), Positives = 64/129 (49%), Gaps = 2/129 (1%)
Frame = +3
Query: 234 IASKMTDISGGQKLIFKRLISK-GEGSKAPE-GSLVIYNYKFYCEPEPEPFDSTRFKKRP 407
+A + DI+ + +++ + G G + P G V +YK + FDS+ + P
Sbjct: 18 VAEQGEDITSKKDRGVLKIVKRVGNGEETPMIGDKVYVHYKGKLS-NGKKFDSSHDRNEP 76
Query: 408 DRQRVGVGQLLPGLDVALQSMSRKERAHFVFDSSVMFGELGVPPRIPERADIYAEIEVID 587
+G GQ++ D+ + +M + E H + +G G P+IP A ++ EIE++D
Sbjct: 77 FVFSLGKGQVIKAWDIGVATMKKGEICHLLCKPEYAYGSAGSLPKIPSNATLFFEIELLD 136
Query: 588 FTEKNLIDD 614
F ++L +D
Sbjct: 137 FKGEDLFED 145
Score = 33.1 bits (74), Expect = 0.91
Identities = 36/129 (27%), Positives = 55/129 (42%), Gaps = 5/129 (3%)
Frame = +3
Query: 276 IFKRLISKGEGSKAP-EGSLVIYNYKFYCEPEPEPFDSTRFKKRPDRQRVGVGQ---LLP 443
I +R KGEG P EG+ V + + C F R VG G+ +
Sbjct: 148 IIRRTKRKGEGYSNPNEGATVEIHLEGRC-------GGRMFDCRDVAFTVGEGEDHDIPI 200
Query: 444 GLDVALQSMSRKERAHFVFDSSVMFGELGVPP-RIPERADIYAEIEVIDFTEKNLIDDFF 620
G+D AL+ M R+E+ FGE G P I A++ E+ + F + + +
Sbjct: 201 GIDKALEKMQREEQCILYLGPRYGFGEAGKPKFGIEPNAELIYEVTLKSFEKAK---ESW 257
Query: 621 EKTVEERLE 647
E +E+LE
Sbjct: 258 EMDTKEKLE 266
>sp|Q64378|FKBP5_MOUSE FK506-binding protein 5 (Peptidyl-prolyl cis-trans isomerase)
(PPIase) (Rotamase) (51 kDa FK506-binding protein)
(FKBP-51)
Length = 456
Score = 54.7 bits (130), Expect = 3e-07
Identities = 31/106 (29%), Positives = 55/106 (51%), Gaps = 1/106 (0%)
Frame = +3
Query: 300 GEGSKAPE-GSLVIYNYKFYCEPEPEPFDSTRFKKRPDRQRVGVGQLLPGLDVALQSMSR 476
G +AP G V +YK + + FDS+ +K+P +G GQ++ D+ + +M +
Sbjct: 41 GTSDEAPMFGDKVYVHYKGMLS-DGKKFDSSHDRKKPFAFSLGQGQVIKAWDIGVSTMKK 99
Query: 477 KERAHFVFDSSVMFGELGVPPRIPERADIYAEIEVIDFTEKNLIDD 614
E H + +G G +IP A ++ EIE++DF ++L +D
Sbjct: 100 GEICHLLCKPEYAYGSAGHLQKIPSNATLFFEIELLDFKGEDLFED 145
>sp|Q5RF88|FKBP5_PONPY FK506-binding protein 5 (Peptidyl-prolyl cis-trans isomerase)
(PPIase) (Rotamase)
Length = 457
Score = 54.7 bits (130), Expect = 3e-07
Identities = 34/129 (26%), Positives = 64/129 (49%), Gaps = 2/129 (1%)
Frame = +3
Query: 234 IASKMTDISGGQKLIFKRLISK-GEGSKAPE-GSLVIYNYKFYCEPEPEPFDSTRFKKRP 407
+A + DI+ + +++ + G G + P G V +YK + FDS+ + P
Sbjct: 18 VAEQGEDITSKKDRGVLKIVKRVGNGEETPMIGDKVYVHYKGKLS-NGKKFDSSHDRNEP 76
Query: 408 DRQRVGVGQLLPGLDVALQSMSRKERAHFVFDSSVMFGELGVPPRIPERADIYAEIEVID 587
+G GQ++ D+ + +M + E H + +G G P+IP A ++ EIE++D
Sbjct: 77 FVFSLGKGQVIKAWDIGVATMKKGEICHLLCKPEYAYGSAGSLPKIPSNATLFFEIELLD 136
Query: 588 FTEKNLIDD 614
F ++L +D
Sbjct: 137 FKGEDLFED 145
Score = 34.3 bits (77), Expect = 0.41
Identities = 37/129 (28%), Positives = 57/129 (44%), Gaps = 5/129 (3%)
Frame = +3
Query: 276 IFKRLISKGEGSKAP-EGSLVIYNYKFYCEPEPEPFDSTRFKKRPDRQRVGVGQ--LLP- 443
I +R KGEG P EG+ V + + C F R VG G+ ++P
Sbjct: 148 IIRRTKRKGEGYSNPNEGATVEIHLEGRC-------GGRMFDCRDVAFTVGEGEDHVIPI 200
Query: 444 GLDVALQSMSRKERAHFVFDSSVMFGELGVPP-RIPERADIYAEIEVIDFTEKNLIDDFF 620
G+D AL+ M R+E+ FGE G P I A++ E+ + F + + +
Sbjct: 201 GIDKALEKMQREEQCILYLGPRYGFGEAGKPKFGIEPNAELIYEVTLKSFEKAK---ESW 257
Query: 621 EKTVEERLE 647
E +E+LE
Sbjct: 258 EMDTKEKLE 266
>sp|Q9XT11|FKBP5_AOTNA FK506-binding protein 5 (Peptidyl-prolyl cis-trans isomerase) (51
kDa FK506-binding immunophilin) (FKBP-51)
Length = 457
Score = 54.3 bits (129), Expect = 4e-07
Identities = 31/108 (28%), Positives = 54/108 (50%), Gaps = 3/108 (2%)
Frame = +3
Query: 300 GEGSKAP---EGSLVIYNYKFYCEPEPEPFDSTRFKKRPDRQRVGVGQLLPGLDVALQSM 470
G G + P + V YN K + FDS+ + P +G GQ++ D+ + +M
Sbjct: 41 GHGEETPMIGDKVYVHYNGKL---SNGKKFDSSHDRNEPFVFSIGKGQVIKAWDIGVATM 97
Query: 471 SRKERAHFVFDSSVMFGELGVPPRIPERADIYAEIEVIDFTEKNLIDD 614
+ E H + +G G P+IP A ++ EIE++DF ++L++D
Sbjct: 98 KKGEICHLLCKPEYAYGATGSLPKIPSNATLFFEIELLDFKGEDLLED 145
Score = 30.0 bits (66), Expect = 7.7
Identities = 35/129 (27%), Positives = 55/129 (42%), Gaps = 5/129 (3%)
Frame = +3
Query: 276 IFKRLISKGEGSKAP-EGSLVIYNYKFYCEPEPEPFDSTRFKKRPDRQRVGVGQ---LLP 443
I +R +GEG P EG+ V + + C F R VG G+ +
Sbjct: 148 IIRRTKRRGEGYSNPNEGARVQIHLEGRC-------GGRVFDCRDVAFTVGEGEDHDIPI 200
Query: 444 GLDVALQSMSRKERAHFVFDSSVMFGELGVPP-RIPERADIYAEIEVIDFTEKNLIDDFF 620
G+D AL+ M R+E+ FGE G P I A++ E+ + F + + +
Sbjct: 201 GIDKALEKMQREEQCILHLGPRYGFGEAGKPKFGIEPNAELIYEVTLKSFEKAK---ESW 257
Query: 621 EKTVEERLE 647
E +E+LE
Sbjct: 258 EMDTKEKLE 266
>sp|Q9XSH5|FKBP5_SAIBB FK506-binding protein 5 (Peptidyl-prolyl cis-trans isomerase) (51
kDa FK506-binding immunophilin) (FKBP-51)
Length = 457
Score = 53.9 bits (128), Expect = 5e-07
Identities = 30/108 (27%), Positives = 54/108 (50%), Gaps = 3/108 (2%)
Frame = +3
Query: 300 GEGSKAP---EGSLVIYNYKFYCEPEPEPFDSTRFKKRPDRQRVGVGQLLPGLDVALQSM 470
G G + P + V YN K + FDS+ + P +G GQ++ D+ + +M
Sbjct: 41 GHGEETPMIGDRVYVHYNGKL---ANGKKFDSSHDRNEPFVFSIGKGQVIKAWDIGVATM 97
Query: 471 SRKERAHFVFDSSVMFGELGVPPRIPERADIYAEIEVIDFTEKNLIDD 614
+ E H + +G G P+IP A ++ E+E++DF ++L++D
Sbjct: 98 KKGEICHLLCKPEYAYGATGSLPKIPSNATLFFEVELLDFKGEDLLED 145
Score = 30.0 bits (66), Expect = 7.7
Identities = 35/129 (27%), Positives = 55/129 (42%), Gaps = 5/129 (3%)
Frame = +3
Query: 276 IFKRLISKGEGSKAP-EGSLVIYNYKFYCEPEPEPFDSTRFKKRPDRQRVGVGQ---LLP 443
I +R +GEG P EG+ V + + C F R VG G+ +
Sbjct: 148 IIRRTKRRGEGYSNPNEGARVQIHLEGRC-------GGRVFDCRDVAFTVGEGEDHDIPI 200
Query: 444 GLDVALQSMSRKERAHFVFDSSVMFGELGVPP-RIPERADIYAEIEVIDFTEKNLIDDFF 620
G+D AL+ M R+E+ FGE G P I A++ E+ + F + + +
Sbjct: 201 GIDKALEKMQREEQCILHLGPRYGFGEAGKPKFGIEPNAELIYEVTLKSFEKAK---ESW 257
Query: 621 EKTVEERLE 647
E +E+LE
Sbjct: 258 EMDTKEKLE 266
>sp|Q9XSI2|FKBP5_SAGOE FK506-binding protein 5 (Peptidyl-prolyl cis-trans isomerase) (51
kDa FK506-binding immunophilin) (FKBP-51)
Length = 457
Score = 52.4 bits (124), Expect = 1e-06
Identities = 29/108 (26%), Positives = 54/108 (50%), Gaps = 3/108 (2%)
Frame = +3
Query: 300 GEGSKAP---EGSLVIYNYKFYCEPEPEPFDSTRFKKRPDRQRVGVGQLLPGLDVALQSM 470
G G + P + V YN K + FDS+ + P +G GQ++ D+ + +M
Sbjct: 41 GHGEETPMIGDKVYVHYNGKL---SNGKKFDSSHDRNEPFVFSIGKGQVIKAWDIGVSTM 97
Query: 471 SRKERAHFVFDSSVMFGELGVPPRIPERADIYAEIEVIDFTEKNLIDD 614
+ E H + +G G P+IP A ++ E+E+++F ++L++D
Sbjct: 98 KKGEICHLLCKPEYAYGATGSLPKIPSNATLFFEVELLNFKGEDLLED 145
Score = 30.0 bits (66), Expect = 7.7
Identities = 35/129 (27%), Positives = 55/129 (42%), Gaps = 5/129 (3%)
Frame = +3
Query: 276 IFKRLISKGEGSKAP-EGSLVIYNYKFYCEPEPEPFDSTRFKKRPDRQRVGVGQ---LLP 443
I +R +GEG P EG+ V + + C F R VG G+ +
Sbjct: 148 IIRRTKRRGEGYSNPNEGARVQIHLEGRC-------GGRVFDCRDVAFTVGEGEDHDIPI 200
Query: 444 GLDVALQSMSRKERAHFVFDSSVMFGELGVPP-RIPERADIYAEIEVIDFTEKNLIDDFF 620
G+D AL+ M R+E+ FGE G P I A++ E+ + F + + +
Sbjct: 201 GIDKALEKMQREEQCILHLGPRYGFGEAGKPKFGIEPNAELIYEVTLKSFEKAK---ESW 257
Query: 621 EKTVEERLE 647
E +E+LE
Sbjct: 258 EMDTKEKLE 266
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 77,681,108
Number of Sequences: 369166
Number of extensions: 1503680
Number of successful extensions: 4510
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 4324
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 4496
length of database: 68,354,980
effective HSP length: 109
effective length of database: 48,218,865
effective search space used: 7618580670
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)