Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_027_L11
(709 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P08253|MMP2_HUMAN 72 kDa type IV collagenase precursor (... 98 2e-20
sp|P50757|MMP2_RABIT 72 kDa type IV collagenase precursor (... 97 3e-20
sp|P33434|MMP2_MOUSE 72 kDa type IV collagenase precursor (... 97 5e-20
sp|P51512|MMP16_HUMAN Matrix metalloproteinase-16 precursor... 97 5e-20
sp|P33436|MMP2_RAT 72 kDa type IV collagenase precursor (72... 97 5e-20
sp|Q9WTR0|MMP16_MOUSE Matrix metalloproteinase-16 precursor... 96 9e-20
sp|O35548|MMP16_RAT Matrix metalloproteinase-16 precursor (... 96 9e-20
sp|Q90611|MMP2_CHICK 72 kDa type IV collagenase precursor (... 94 4e-19
sp|Q9R0S2|MMP24_MOUSE Matrix metalloproteinase-24 precursor... 92 1e-18
sp|Q99PW6|MMP24_RAT Matrix metalloproteinase-24 precursor (... 92 1e-18
>sp|P08253|MMP2_HUMAN 72 kDa type IV collagenase precursor (72 kDa gelatinase) (Matrix
metalloproteinase-2) (MMP-2) (Gelatinase A) (TBE-1)
Length = 660
Score = 98.2 bits (243), Expect = 2e-20
Identities = 65/199 (32%), Positives = 98/199 (49%), Gaps = 7/199 (3%)
Frame = +3
Query: 33 VFSGKLQWR--IDFSKTVTSWISYELRD---GPEDLTYYWPVLPKTIDGIDGGIERKDQK 197
VF G Q R I F K W + RD GP + +WP LP+ ID + + ++K
Sbjct: 474 VFDGIAQIRGEIFFFKDRFIWRTVTPRDKPMGPLLVATFWPELPEKIDAVYEAPQ--EEK 531
Query: 198 IYLFRKNKFWLLEDNTKLFRPDYADGLPLTVLGLPSSLEKIDTIFRWDYNKAIYIMAGDK 377
F N++W+ +T + PLT LGLP ++++D F W NK YI AGDK
Sbjct: 532 AVFFAGNEYWIYSASTL----ERGYPKPLTSLGLPPDVQRVDAAFNWSKNKKTYIFAGDK 587
Query: 378 YWKINENSGEFGFTYPRYPRYIHSVWKDIPLPVDVAYTGLH--GKTFFIKGKYFYEFNNL 551
+W+ NE + P +P+ I W IP +D A L G ++F KG Y+ + N
Sbjct: 588 FWRYNEVKKKMD---PGFPKLIADAWNAIPDNLD-AVVDLQGGGHSYFFKGAYYLKLENQ 643
Query: 552 EMRIVEGGPRPLTAAWIGC 608
++ V+ G + + W+GC
Sbjct: 644 SLKSVKFG--SIKSDWLGC 660
>sp|P50757|MMP2_RABIT 72 kDa type IV collagenase precursor (72 kDa gelatinase) (Matrix
metalloproteinase-2) (MMP-2) (Gelatinase A)
Length = 662
Score = 97.4 bits (241), Expect = 3e-20
Identities = 62/197 (31%), Positives = 96/197 (48%), Gaps = 2/197 (1%)
Frame = +3
Query: 24 ELYVFSGKLQWRIDFSKTVTSWISYELRDGPEDLTYYWPVLPKTIDGIDGGIERKDQKIY 203
E++ F + WR TVT + GP + +WP LP+ ID + + ++K
Sbjct: 486 EIFFFKDRFIWR-----TVTPG---DKPMGPLLVATFWPELPEKIDAVYEAPQ--EEKAV 535
Query: 204 LFRKNKFWLLEDNTKLFRPDYADGLPLTVLGLPSSLEKIDTIFRWDYNKAIYIMAGDKYW 383
F N++W+ +T + PLT LGLP ++++D F W NK YI AGDK+W
Sbjct: 536 FFAGNEYWVYSASTL----ERGYPKPLTSLGLPPDVQRVDAAFNWSKNKKTYIFAGDKFW 591
Query: 384 KINENSGEFGFTYPRYPRYIHSVWKDIPLPVDVAYTGLHGK--TFFIKGKYFYEFNNLEM 557
+ NE + P +PR I W IP +D A L G ++F KG Y+ + N +
Sbjct: 592 RYNEVKKKMD---PGFPRLIADAWNAIPDHLD-AVVDLQGSGHSYFFKGTYYLKLENQSL 647
Query: 558 RIVEGGPRPLTAAWIGC 608
+ V+ G + W+GC
Sbjct: 648 KSVKVG--SIKTDWLGC 662
>sp|P33434|MMP2_MOUSE 72 kDa type IV collagenase precursor (72 kDa gelatinase) (Matrix
metalloproteinase-2) (MMP-2) (Gelatinase A)
Length = 662
Score = 96.7 bits (239), Expect = 5e-20
Identities = 65/199 (32%), Positives = 98/199 (49%), Gaps = 7/199 (3%)
Frame = +3
Query: 33 VFSGKLQWR--IDFSKTVTSWISYELRD---GPEDLTYYWPVLPKTIDGIDGGIERKDQK 197
VF G Q R I F K W + RD GP + +WP LP+ ID + + ++K
Sbjct: 476 VFDGIAQIRGEIFFFKDRFIWRTVTPRDKPTGPLLVATFWPELPEKIDAVYEAPQ--EEK 533
Query: 198 IYLFRKNKFWLLEDNTKLFRPDYADGLPLTVLGLPSSLEKIDTIFRWDYNKAIYIMAGDK 377
F N++W+ +T + PLT LGLP ++++D F W NK YI AGDK
Sbjct: 534 AVFFAGNEYWVYSASTL----ERGYPKPLTSLGLPPDVQQVDAAFNWSKNKKTYIFAGDK 589
Query: 378 YWKINENSGEFGFTYPRYPRYIHSVWKDIPLPVDVAYTGLH--GKTFFIKGKYFYEFNNL 551
+W+ NE + P +P+ I W IP +D A L G ++F KG Y+ + N
Sbjct: 590 FWRYNEVKKKMD---PGFPKLIADSWNAIPDNLD-AVVDLQGGGHSYFFKGAYYLKLENQ 645
Query: 552 EMRIVEGGPRPLTAAWIGC 608
++ V+ G + + W+GC
Sbjct: 646 SLKSVKFG--SIKSDWLGC 662
>sp|P51512|MMP16_HUMAN Matrix metalloproteinase-16 precursor (MMP-16) (Membrane-type
matrix metalloproteinase 3) (MT-MMP 3) (MTMMP3)
(Membrane-type-3 matrix metalloproteinase) (MT3-MMP)
(MT3MMP) (MMP-X2)
Length = 607
Score = 96.7 bits (239), Expect = 5e-20
Identities = 60/196 (30%), Positives = 97/196 (49%), Gaps = 1/196 (0%)
Frame = +3
Query: 24 ELYVFSGKLQWRIDFSKTVTSWISYELRDGPEDLTYYWPVLPKTIDGIDGGIERKDQKIY 203
E++VF + WR+ ++ + + P +TY+W LP +ID + E D
Sbjct: 356 EMFVFKDQWFWRVRNNRVMDGY--------PMQITYFWRGLPPSIDAV---YENSDGNFV 404
Query: 204 LFRKNKFWLLEDNTKLFRPDYADGLPLTVLGLPSSLEKIDTIFRWDYNKAIYIMAGDKYW 383
F+ NK+W+ +D T +P Y L G+P ID+ W+ Y GD+YW
Sbjct: 405 FFKGNKYWVFKDTT--LQPGYPHDLITLGSGIPP--HGIDSAIWWEDVGKTYFFKGDRYW 460
Query: 384 KINENSGEFGFTYPRYPRYIHSVWKDIPLPVDVAYTGL-HGKTFFIKGKYFYEFNNLEMR 560
+ +E E P YP+ I +VWK IP A+ +G T+F KGK +++FNN ++
Sbjct: 461 RYSE---EMKTMDPGYPKPI-TVWKGIPESPQGAFVHKENGFTYFYKGKEYWKFNNQILK 516
Query: 561 IVEGGPRPLTAAWIGC 608
+ G PR + ++GC
Sbjct: 517 VEPGYPRSILKDFMGC 532
>sp|P33436|MMP2_RAT 72 kDa type IV collagenase precursor (72 kDa gelatinase) (Matrix
metalloproteinase-2) (MMP-2) (Gelatinase A)
Length = 662
Score = 96.7 bits (239), Expect = 5e-20
Identities = 65/199 (32%), Positives = 98/199 (49%), Gaps = 7/199 (3%)
Frame = +3
Query: 33 VFSGKLQWR--IDFSKTVTSWISYELRD---GPEDLTYYWPVLPKTIDGIDGGIERKDQK 197
VF G Q R I F K W + RD GP + +WP LP+ ID + + ++K
Sbjct: 476 VFDGIAQIRGEIFFFKDRFIWRTVTPRDKPTGPLLVATFWPELPEKIDAVYEAPQ--EEK 533
Query: 198 IYLFRKNKFWLLEDNTKLFRPDYADGLPLTVLGLPSSLEKIDTIFRWDYNKAIYIMAGDK 377
F N++W+ +T + PLT LGLP ++++D F W NK YI AGDK
Sbjct: 534 AVFFAGNEYWVYSASTL----ERGYPKPLTSLGLPPDVQQVDAAFNWSKNKKTYIFAGDK 589
Query: 378 YWKINENSGEFGFTYPRYPRYIHSVWKDIPLPVDVAYTGLH--GKTFFIKGKYFYEFNNL 551
+W+ NE + P +P+ I W IP +D A L G ++F KG Y+ + N
Sbjct: 590 FWRYNEVKKKMD---PGFPKLIADSWNAIPDNLD-AVVDLQGGGHSYFFKGAYYLKLENQ 645
Query: 552 EMRIVEGGPRPLTAAWIGC 608
++ V+ G + + W+GC
Sbjct: 646 SLKSVKFG--SIKSDWLGC 662
>sp|Q9WTR0|MMP16_MOUSE Matrix metalloproteinase-16 precursor (MMP-16) (Membrane-type
matrix metalloproteinase 3) (MT-MMP 3) (MTMMP3)
(Membrane-type-3 matrix metalloproteinase) (MT3-MMP)
(MT3MMP)
Length = 607
Score = 95.9 bits (237), Expect = 9e-20
Identities = 59/196 (30%), Positives = 97/196 (49%), Gaps = 1/196 (0%)
Frame = +3
Query: 24 ELYVFSGKLQWRIDFSKTVTSWISYELRDGPEDLTYYWPVLPKTIDGIDGGIERKDQKIY 203
E++VF + WR+ ++ + + P +TY+W LP +ID + E D
Sbjct: 356 EMFVFKDQWFWRVRNNRVMDGY--------PMQITYFWRGLPPSIDAV---YENSDGNFV 404
Query: 204 LFRKNKFWLLEDNTKLFRPDYADGLPLTVLGLPSSLEKIDTIFRWDYNKAIYIMAGDKYW 383
F+ NK+W+ +D T +P Y L G+P ID+ W+ Y GD+YW
Sbjct: 405 FFKGNKYWVFKDTT--LQPGYPHDLITLGNGIPP--HGIDSAIWWEDVGKTYFFKGDRYW 460
Query: 384 KINENSGEFGFTYPRYPRYIHSVWKDIPLPVDVAYTGL-HGKTFFIKGKYFYEFNNLEMR 560
+ +E E P YP+ I ++WK IP A+ +G T+F KGK +++FNN ++
Sbjct: 461 RYSE---EMKTMDPGYPKPI-TIWKGIPESPQGAFVHKENGFTYFYKGKEYWKFNNQILK 516
Query: 561 IVEGGPRPLTAAWIGC 608
+ G PR + ++GC
Sbjct: 517 VEPGYPRSILKDFMGC 532
>sp|O35548|MMP16_RAT Matrix metalloproteinase-16 precursor (MMP-16) (Membrane-type
matrix metalloproteinase 3) (MT-MMP 3) (MTMMP3)
(Membrane-type-3 matrix metalloproteinase) (MT3-MMP)
(MT3MMP)
Length = 607
Score = 95.9 bits (237), Expect = 9e-20
Identities = 59/196 (30%), Positives = 97/196 (49%), Gaps = 1/196 (0%)
Frame = +3
Query: 24 ELYVFSGKLQWRIDFSKTVTSWISYELRDGPEDLTYYWPVLPKTIDGIDGGIERKDQKIY 203
E++VF + WR+ ++ + + P +TY+W LP +ID + E D
Sbjct: 356 EMFVFKDQWFWRVRNNRVMDGY--------PMQITYFWRGLPPSIDAV---YENSDGNFV 404
Query: 204 LFRKNKFWLLEDNTKLFRPDYADGLPLTVLGLPSSLEKIDTIFRWDYNKAIYIMAGDKYW 383
F+ NK+W+ +D T +P Y L G+P ID+ W+ Y GD+YW
Sbjct: 405 FFKGNKYWVFKDTT--LQPGYPHDLITLGNGIPP--HGIDSAIWWEDVGKTYFFKGDRYW 460
Query: 384 KINENSGEFGFTYPRYPRYIHSVWKDIPLPVDVAYTGL-HGKTFFIKGKYFYEFNNLEMR 560
+ +E E P YP+ I ++WK IP A+ +G T+F KGK +++FNN ++
Sbjct: 461 RYSE---EMKTMDPGYPKPI-TIWKGIPESPQGAFVHKENGFTYFYKGKEYWKFNNQILK 516
Query: 561 IVEGGPRPLTAAWIGC 608
+ G PR + ++GC
Sbjct: 517 VEPGYPRSILKDFMGC 532
>sp|Q90611|MMP2_CHICK 72 kDa type IV collagenase precursor (72 kDa gelatinase) (Matrix
metalloproteinase-2) (MMP-2) (Gelatinase A)
Length = 663
Score = 94.0 bits (232), Expect = 4e-19
Identities = 64/199 (32%), Positives = 97/199 (48%), Gaps = 7/199 (3%)
Frame = +3
Query: 33 VFSGKLQWR--IDFSKTVTSWISYELRD---GPEDLTYYWPVLPKTIDGIDGGIERKDQK 197
VF G Q R I F K W + R GP + +WP LP+ ID + + D+K
Sbjct: 477 VFDGVAQIRGEIFFFKDRFMWRTVNPRGKPTGPLLVATFWPDLPEKIDAVYESPQ--DEK 534
Query: 198 IYLFRKNKFWLLEDNTKLFRPDYADGLPLTVLGLPSSLEKIDTIFRWDYNKAIYIMAGDK 377
F N++W+ + D LT LGLP +++ID F W NK YI +GD+
Sbjct: 535 AVFFAGNEYWVYTASNL----DRGYPKKLTSLGLPPDVQRIDAAFNWGRNKKTYIFSGDR 590
Query: 378 YWKINENSGEFGFTYPRYPRYIHSVWKDIPLPVDVAYTGL--HGKTFFIKGKYFYEFNNL 551
YWK NE + P++I W +P +D A GL G T+F K +Y+ + +
Sbjct: 591 YWKYNEEKKKMELA---TPKFIADSWNGVPDNLD-AVLGLTDSGYTYFFKDQYYLQMEDK 646
Query: 552 EMRIVEGGPRPLTAAWIGC 608
++IV+ G +++ W+GC
Sbjct: 647 SLKIVKIG--KISSDWLGC 663
>sp|Q9R0S2|MMP24_MOUSE Matrix metalloproteinase-24 precursor (MMP-24) (Membrane-type
matrix metalloproteinase 5) (MT-MMP 5) (Membrane-type-5
matrix metalloproteinase) (MT5-MMP) (MMP-21)
Length = 618
Score = 92.4 bits (228), Expect = 1e-18
Identities = 60/198 (30%), Positives = 96/198 (48%), Gaps = 1/198 (0%)
Frame = +3
Query: 24 ELYVFSGKLQWRIDFSKTVTSWISYELRDGPEDLTYYWPVLPKTIDGIDGGIERKDQKIY 203
E++VF + WR+ ++ + P + +W LP ID ER D +
Sbjct: 366 EMFVFKDRWFWRLRNNRVQEGY--------PMQIEQFWKGLPARIDA---AYERADGRFV 414
Query: 204 LFRKNKFWLLEDNTKLFRPDYADGLPLTVLGLPSSLEKIDTIFRWDYNKAIYIMAGDKYW 383
F+ +K+W+ ++ T P Y L LP E IDT RW+ Y G++YW
Sbjct: 415 FFKGDKYWVFKEVT--VEPGYPHSLGELGSCLPR--EGIDTALRWEPVGKTYFFKGERYW 470
Query: 384 KINENSGEFGFTYPRYPRYIHSVWKDIPLPVDVAYTGLHGK-TFFIKGKYFYEFNNLEMR 560
+ +E E T P YP+ I +VWK IP A+ G T+F KG+ +++F+N ++
Sbjct: 471 RYSE---ERRATDPGYPKPI-TVWKGIPQAPQGAFISKEGYYTYFYKGRDYWKFDNQKLS 526
Query: 561 IVEGGPRPLTAAWIGCKK 614
+ G PR + W+GCK+
Sbjct: 527 VEPGYPRNILRDWMGCKQ 544
>sp|Q99PW6|MMP24_RAT Matrix metalloproteinase-24 precursor (MMP-24) (Membrane-type
matrix metalloproteinase 5) (MT-MMP 5) (Membrane-type-5
matrix metalloproteinase) (MT5-MMP)
Length = 618
Score = 92.4 bits (228), Expect = 1e-18
Identities = 60/198 (30%), Positives = 96/198 (48%), Gaps = 1/198 (0%)
Frame = +3
Query: 24 ELYVFSGKLQWRIDFSKTVTSWISYELRDGPEDLTYYWPVLPKTIDGIDGGIERKDQKIY 203
E++VF + WR+ ++ + P + +W LP ID ER D +
Sbjct: 366 EMFVFKDRWFWRLRNNRVQEGY--------PMQIEQFWKGLPARIDA---AYERADGRFV 414
Query: 204 LFRKNKFWLLEDNTKLFRPDYADGLPLTVLGLPSSLEKIDTIFRWDYNKAIYIMAGDKYW 383
F+ +K+W+ ++ T P Y L LP E IDT RW+ Y G++YW
Sbjct: 415 FFKGDKYWVFKEVT--VEPGYPHSLGELGSCLPR--EGIDTALRWEPVGKTYFFKGERYW 470
Query: 384 KINENSGEFGFTYPRYPRYIHSVWKDIPLPVDVAYTGLHGK-TFFIKGKYFYEFNNLEMR 560
+ +E E T P YP+ I +VWK IP A+ G T+F KG+ +++F+N ++
Sbjct: 471 RYSE---ERRATDPGYPKPI-TVWKGIPQAPQGAFISKEGYYTYFYKGRDYWKFDNQKLS 526
Query: 561 IVEGGPRPLTAAWIGCKK 614
+ G PR + W+GCK+
Sbjct: 527 VEPGYPRNILRDWMGCKQ 544
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 88,102,315
Number of Sequences: 369166
Number of extensions: 2016899
Number of successful extensions: 4455
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 4135
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 4293
length of database: 68,354,980
effective HSP length: 107
effective length of database: 48,588,335
effective search space used: 6219306880
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)