Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_027_J21
(877 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q11002|CANA_DROME Calpain A (Calcium-activated neutral p... 135 1e-31
sp|Q9VT65|CANB_DROME Calpain B (Calcium-activated neutral p... 135 1e-31
sp|O35920|CAN9_RAT Calpain-9 (Digestive tract-specific calp... 122 1e-27
sp|Q92177|CAN3_CHICK Calpain-3 (Calpain L3) (Calpain p94) (... 122 2e-27
sp|Q9D805|CAN9_MOUSE Calpain-9 (Digestive tract-specific ca... 121 2e-27
sp|O14815|CAN9_HUMAN Calpain-9 (Digestive tract-specific ca... 120 6e-27
sp|P16259|CAN3_RAT Calpain-3 (Calpain L3) (Calpain p94) (Ca... 119 1e-26
sp|Q64691|CAN3_MOUSE Calpain-3 (Calpain L3) (Calpain p94) (... 119 1e-26
sp|P20807|CAN3_HUMAN Calpain-3 (Calpain L3) (Calpain p94) (... 118 2e-26
sp|Q9TTH8|CAN3_SHEEP Calpain-3 (Calpain L3) (Calpain p94) (... 118 2e-26
>sp|Q11002|CANA_DROME Calpain A (Calcium-activated neutral proteinase A) (CANP A)
[Contains: Calpain A catalytic subunit]
Length = 828
Score = 135 bits (340), Expect = 1e-31
Identities = 70/146 (47%), Positives = 92/146 (63%), Gaps = 3/146 (2%)
Frame = +3
Query: 3 SFQDFVKNFEKMEICHLGPQSLESDQLGGKPKSRWEMCLEIGEWKNRLNAGGCRNFLDTF 182
SFQDF+ +F+++EIC+L P SL DQ K +WEM + GEW + AGGCRNFLDTF
Sbjct: 370 SFQDFLNHFDRVEICNLSPDSLTEDQQNSG-KRKWEMSMYEGEWTPGVTAGGCRNFLDTF 428
Query: 183 WTNSQFRVKXXXXXXXXXXNLGTIIVGLMQKDMRKRRKEGVEFYTIGYAIYQLKD---EN 353
W N Q+ + T+IV LMQK+ R +R G+E TIG+AIY L D EN
Sbjct: 429 WHNPQYIITLVDPDEEDEEGQCTVIVALMQKNRRSKRNMGMECLTIGFAIYSLNDRELEN 488
Query: 354 QGPLDVNFFKYNASVAKAPSFINLRE 431
+ P +NFF+Y +SV ++P FIN RE
Sbjct: 489 R-PQGLNFFRYKSSVGRSPHFINTRE 513
Score = 43.5 bits (101), Expect = 8e-04
Identities = 37/129 (28%), Positives = 58/129 (44%), Gaps = 18/129 (13%)
Frame = +2
Query: 392 IGSKSAFIYQSSRECVDVTNLPPGTYVIVPSTFEPNQESCFFS*EYFLRNLMNQVNSMSK 571
+G FI ++RE LPPG Y+IVPSTF+PN+E E+ +R N+M +
Sbjct: 502 VGRSPHFI--NTREVCARFKLPPGHYLIVPSTFDPNEEG-----EFIIRVFSETQNNMEE 554
Query: 572 R--------------PWFLQSQ----QKQSLQPMMHK*LL*EIHLIKFAGQDLEIDAYEL 697
P F + QK+ L+ + AG+D+E+D EL
Sbjct: 555 NDDHVGYGGKADTITPGFPTPKPIDPQKEGLRRLFD----------SIAGKDMEVDWMEL 604
Query: 698 QDILNTAFK 724
+ IL+ + +
Sbjct: 605 KRILDHSMR 613
Score = 39.7 bits (91), Expect = 0.011
Identities = 16/28 (57%), Positives = 23/28 (82%)
Frame = +3
Query: 789 VAMMDYDQSGKLGFDEFKVLWTDLRLWK 872
VAM+D D+SGKLGF+EF+ L +++ WK
Sbjct: 708 VAMLDADKSGKLGFEEFETLLSEIAKWK 735
>sp|Q9VT65|CANB_DROME Calpain B (Calcium-activated neutral proteinase B) (CANP B)
[Contains: Calpain B catalytic subunit 1; Calpain B
catalytic subunit 2]
Length = 925
Score = 135 bits (340), Expect = 1e-31
Identities = 68/145 (46%), Positives = 91/145 (62%), Gaps = 2/145 (1%)
Frame = +3
Query: 3 SFQDFVKNFEKMEICHLGPQSLESDQLGGKPKSRWEMCLEIGEWKNRLNAGGCRNFLDTF 182
SFQDF+ +F+++EIC+L P SL DQ + +WEM + GEW + + AGGCRNFL+TF
Sbjct: 541 SFQDFLNHFDRVEICNLSPDSLTEDQQHSS-RRKWEMSMFEGEWTSGVTAGGCRNFLETF 599
Query: 183 WTNSQFRVKXXXXXXXXXXNLGTIIVGLMQKDMRKRRKEGVEFYTIGYAIYQLKDENQ-- 356
W N Q+ + T IV LMQK+ R +R G++ TIG+AIY L D +
Sbjct: 600 WHNPQYIISLEDPDDEDDDGKCTAIVALMQKNRRSKRNVGIDCLTIGFAIYHLTDRDMQV 659
Query: 357 GPLDVNFFKYNASVAKAPSFINLRE 431
P +NFFKY ASVA++P FIN RE
Sbjct: 660 KPQGLNFFKYRASVARSPHFINTRE 684
Score = 42.7 bits (99), Expect = 0.001
Identities = 41/133 (30%), Positives = 61/133 (45%), Gaps = 11/133 (8%)
Frame = +2
Query: 422 SSRECVDVTNLPPGTYVIVPSTFEPNQESCFFS*EYFLRNLMNQVNSMSKRP---WFLQS 592
++RE LPPG Y+IVPSTF+PN+E E+ +R N+M + F ++
Sbjct: 681 NTREVCARFKLPPGHYLIVPSTFDPNEEG-----EFIIRVFSETRNNMEENDDEVGFGET 735
Query: 593 QQK--QSLQPMMHK------*LL*EIHLIKFAGQDLEIDAYELQDILNTAFKKGADGKYF 748
+ SL P K + AG D E+D EL+ IL+ + + G
Sbjct: 736 DDRIAPSLPPPTPKEEDDPQRIALRRLFDSVAGSDEEVDWQELKRILDHSMRDVMVGS-- 793
Query: 749 KFDGFSIETSKSM 787
DGFS + +SM
Sbjct: 794 --DGFSKDAVRSM 804
Score = 41.6 bits (96), Expect = 0.003
Identities = 20/54 (37%), Positives = 32/54 (59%)
Frame = +3
Query: 711 IQHSKKEPMANISSLMGLALKHQKVWVAMMDYDQSGKLGFDEFKVLWTDLRLWK 872
+ HS ++ M A++ VAM+D D+SG+LGF+EF+ L TD+ W+
Sbjct: 782 LDHSMRDVMVGSDGFSKDAVRSM---VAMLDKDRSGRLGFEEFEALLTDIAKWR 832
>sp|O35920|CAN9_RAT Calpain-9 (Digestive tract-specific calpain) (nCL-4)
Length = 674
Score = 122 bits (306), Expect = 1e-27
Identities = 64/143 (44%), Positives = 90/143 (62%)
Frame = +3
Query: 3 SFQDFVKNFEKMEICHLGPQSLESDQLGGKPKSRWEMCLEIGEWKNRLNAGGCRNFLDTF 182
+F+DF +F+K+EIC+L P +LE + L +WE+ + G W AGGCRNFLDTF
Sbjct: 302 AFEDFKTHFDKVEICNLTPDALEDNTL-----HKWEVTIHQGSWVRGSTAGGCRNFLDTF 356
Query: 183 WTNSQFRVKXXXXXXXXXXNLGTIIVGLMQKDMRKRRKEGVEFYTIGYAIYQLKDENQGP 362
WTN Q +K T + LMQKD R+ ++ G TIGYAIYQ D++ G
Sbjct: 357 WTNPQ--IKLSLTERDEGQEGCTFLAALMQKDRRRLKRFGANMLTIGYAIYQCPDKD-GH 413
Query: 363 LDVNFFKYNASVAKAPSFINLRE 431
L+ +FF+Y+AS+A++ +FINLRE
Sbjct: 414 LNRDFFRYHASLARSKTFINLRE 436
Score = 44.3 bits (103), Expect = 5e-04
Identities = 31/110 (28%), Positives = 56/110 (50%), Gaps = 10/110 (9%)
Frame = +2
Query: 428 RECVDVTNLPPGTYVIVPSTFEPNQESCF----FS*EYFL-----RNLMNQVNSMSK-RP 577
RE LPPG Y+++PSTFEP+QE+ F FS + + N+ + + K P
Sbjct: 435 REVSGRFQLPPGDYILIPSTFEPHQEADFCLRIFSEKKAVTQDLDENIDIDLPELPKPTP 494
Query: 578 WFLQSQQKQSLQPMMHK*LL*EIHLIKFAGQDLEIDAYELQDILNTAFKK 727
++++++ + + + AG+D+E+ A EL+ +LN +K
Sbjct: 495 QEEETEEERQFRALFR----------RIAGEDMEVSAEELEYVLNAVLQK 534
Score = 35.0 bits (79), Expect = 0.27
Identities = 12/29 (41%), Positives = 20/29 (68%)
Frame = +3
Query: 789 VAMMDYDQSGKLGFDEFKVLWTDLRLWKE 875
+++MD +GK+ F+EF+V W LR W +
Sbjct: 554 ISLMDTSGNGKMEFEEFRVFWDKLRYWMD 582
>sp|Q92177|CAN3_CHICK Calpain-3 (Calpain L3) (Calpain p94) (Calcium-activated neutral
proteinase 3) (CANP 3) (Muscle-specific
calcium-activated neutral protease 3)
Length = 810
Score = 122 bits (305), Expect = 2e-27
Identities = 63/148 (42%), Positives = 91/148 (61%), Gaps = 5/148 (3%)
Frame = +3
Query: 3 SFQDFVKNFEKMEICHLGPQSLESDQLGGKPKSRWEMCLEIGEWKNRLNAGGCRNFLDTF 182
S +DF+++F K+EIC+L P +LE+D+L W + + G W +AGGCRN+ DTF
Sbjct: 393 SLEDFMRHFTKLEICNLTPDTLEADKL-----QTWTVSVNEGRWVRGCSAGGCRNYPDTF 447
Query: 183 WTNSQFRVKXXXXXXXXXXN--LGTIIVGLMQKDMRKRRKEGVEFYTIGYAIYQLKDENQ 356
WTN Q+R+K + + +V LMQK+ RK RK G YTIG+AIY++ E
Sbjct: 448 WTNPQYRLKLLEEDDDPEDEEVICSFLVALMQKNRRKERKLGANLYTIGFAIYEVPKEMH 507
Query: 357 GP---LDVNFFKYNASVAKAPSFINLRE 431
G L +FF YNAS A++ ++IN+RE
Sbjct: 508 GTKHHLQKDFFLYNASKARSKTYINMRE 535
Score = 42.0 bits (97), Expect = 0.002
Identities = 16/39 (41%), Positives = 26/39 (66%)
Frame = +3
Query: 759 GLALKHQKVWVAMMDYDQSGKLGFDEFKVLWTDLRLWKE 875
G L+ + +A+MD D SGK+ FDEF+ LW ++ W++
Sbjct: 680 GFELESSRSMIALMDTDGSGKINFDEFRHLWDKIKSWQK 718
Score = 40.0 bits (92), Expect = 0.009
Identities = 47/186 (25%), Positives = 74/186 (39%), Gaps = 48/186 (25%)
Frame = +2
Query: 374 LFQVQRIGSKSAFIYQSSRECVDVTNLPPGTYVIVPSTFEPNQESCFFS*EYF-LRNLMN 550
L+ + SK+ Y + RE + LPP YVI+PST+EP+QE F + R+L
Sbjct: 519 LYNASKARSKT---YINMREISERFRLPPSEYVIIPSTYEPHQEGEFILRVFSEKRSLSE 575
Query: 551 QVNSMSK----------RPWFLQSQQKQSLQPMMHK*LL*EIHLIKFAGQD--------- 673
+V +M + +P S + S + E+ + AG+D
Sbjct: 576 EVENMIEADRPSKKKKGKPIIFVSDRANSNK---------ELTTDEDAGKDGEKTHVDEK 626
Query: 674 ----------------------------LEIDAYELQDILNTAFKKGADGKYFKFDGFSI 769
+EI EL+++LN KK D K +GF +
Sbjct: 627 KRSSAKAREKSEEETQFRNIFRQIAGDDMEICREELRNVLNNVVKKHKD---LKTEGFEL 683
Query: 770 ETSKSM 787
E+S+SM
Sbjct: 684 ESSRSM 689
>sp|Q9D805|CAN9_MOUSE Calpain-9 (Digestive tract-specific calpain) (nCL-4)
Length = 690
Score = 121 bits (304), Expect = 2e-27
Identities = 65/143 (45%), Positives = 88/143 (61%)
Frame = +3
Query: 3 SFQDFVKNFEKMEICHLGPQSLESDQLGGKPKSRWEMCLEIGEWKNRLNAGGCRNFLDTF 182
+F+DF +F+K+EIC+L P +LE L RWE+ + G W AGGCRNFLDTF
Sbjct: 320 AFKDFKIHFDKVEICNLTPDALEDSAL-----HRWEVTIHQGSWVRGSTAGGCRNFLDTF 374
Query: 183 WTNSQFRVKXXXXXXXXXXNLGTIIVGLMQKDMRKRRKEGVEFYTIGYAIYQLKDENQGP 362
WTN Q +K T + LMQKD R+ ++ G TIGYAIYQ D++ G
Sbjct: 375 WTNPQ--IKLSLTERDEGQEGCTFLAALMQKDRRRLKRFGANMLTIGYAIYQCPDKD-GH 431
Query: 363 LDVNFFKYNASVAKAPSFINLRE 431
L +FF+Y+AS+A++ +FINLRE
Sbjct: 432 LSRDFFRYHASLARSKTFINLRE 454
Score = 46.6 bits (109), Expect = 9e-05
Identities = 32/110 (29%), Positives = 57/110 (51%), Gaps = 10/110 (9%)
Frame = +2
Query: 428 RECVDVTNLPPGTYVIVPSTFEPNQESCF----FS*EYFL-----RNLMNQVNSMSK-RP 577
RE + LPPG Y+++PSTFEP+QE+ F FS + + N+ + + K P
Sbjct: 453 REVSERFQLPPGDYILIPSTFEPHQEADFCLRIFSEKRAVTRDLDENIDIDLPELPKPTP 512
Query: 578 WFLQSQQKQSLQPMMHK*LL*EIHLIKFAGQDLEIDAYELQDILNTAFKK 727
+++++Q + + + AG+D+E+ A EL+ +LN +K
Sbjct: 513 QEEETEEEQQFRALFQ----------RVAGEDMEVSAEELEYVLNAVLQK 552
Score = 33.9 bits (76), Expect = 0.61
Identities = 12/29 (41%), Positives = 20/29 (68%)
Frame = +3
Query: 789 VAMMDYDQSGKLGFDEFKVLWTDLRLWKE 875
+++MD +GKL F+EF+V W L+ W +
Sbjct: 570 ISLMDTSGNGKLEFEEFRVFWDKLKHWMD 598
>sp|O14815|CAN9_HUMAN Calpain-9 (Digestive tract-specific calpain) (nCL-4) (CG36 protein)
Length = 690
Score = 120 bits (300), Expect = 6e-27
Identities = 63/143 (44%), Positives = 90/143 (62%)
Frame = +3
Query: 3 SFQDFVKNFEKMEICHLGPQSLESDQLGGKPKSRWEMCLEIGEWKNRLNAGGCRNFLDTF 182
+F+DF +F+K+EIC+L P +LE D + +WE+ + G W AGGCRNFLDTF
Sbjct: 320 AFKDFKAHFDKVEICNLTPDALEEDAI-----HKWEVTVHQGSWVRGSTAGGCRNFLDTF 374
Query: 183 WTNSQFRVKXXXXXXXXXXNLGTIIVGLMQKDMRKRRKEGVEFYTIGYAIYQLKDENQGP 362
WTN Q +K + +V LMQKD RK ++ G TIGYAIY+ D+++
Sbjct: 375 WTNPQ--IKLSLTEKDEGQEECSFLVALMQKDRRKLKRFGANVLTIGYAIYECPDKDE-H 431
Query: 363 LDVNFFKYNASVAKAPSFINLRE 431
L+ +FF+Y+AS A++ +FINLRE
Sbjct: 432 LNKDFFRYHASRARSKTFINLRE 454
Score = 51.6 bits (122), Expect = 3e-06
Identities = 38/125 (30%), Positives = 64/125 (51%), Gaps = 5/125 (4%)
Frame = +2
Query: 428 RECVDVTNLPPGTYVIVPSTFEPNQESCF----FS*EYFL-RNLMNQVNSMSKRPWFLQS 592
RE D LPPG Y+++PSTFEP+QE+ F FS + + R++ V+ P
Sbjct: 453 REVSDRFKLPPGEYILIPSTFEPHQEADFCLRIFSEKKAITRDMDGNVDIDLPEPPKPTP 512
Query: 593 QQKQSLQPMMHK*LL*EIHLIKFAGQDLEIDAYELQDILNTAFKKGADGKYFKFDGFSIE 772
+++ + + L ++ AG+D+E+ A EL+ +LN +K D K+ K S +
Sbjct: 513 PDQETEEEQRFRALFEQV-----AGEDMEVTAEELEYVLNAVLQKKKDIKFKKLSLISCK 567
Query: 773 TSKSM 787
S+
Sbjct: 568 NIISL 572
Score = 37.0 bits (84), Expect = 0.072
Identities = 17/36 (47%), Positives = 23/36 (63%)
Frame = +3
Query: 762 LALKHQKVWVAMMDYDQSGKLGFDEFKVLWTDLRLW 869
L+L K +++MD +GKL FDEFKV W L+ W
Sbjct: 561 LSLISCKNIISLMDTSGNGKLEFDEFKVFWDKLKQW 596
>sp|P16259|CAN3_RAT Calpain-3 (Calpain L3) (Calpain p94) (Calcium-activated neutral
proteinase 3) (CANP 3) (Muscle-specific
calcium-activated neutral protease 3)
Length = 821
Score = 119 bits (298), Expect = 1e-26
Identities = 64/148 (43%), Positives = 91/148 (61%), Gaps = 5/148 (3%)
Frame = +3
Query: 3 SFQDFVKNFEKMEICHLGPQSLESDQLGGKPKSRWEMCLEIGEWKNRLNAGGCRNFLDTF 182
S+ DFV +F K+EIC+L +LESD+L W + + G W +AGGCRNF DTF
Sbjct: 400 SYDDFVYHFTKLEICNLTADALESDKL-----QTWTVSVNEGRWVRGCSAGGCRNFPDTF 454
Query: 183 WTNSQFRVKXXXXXXXXXXN--LGTIIVGLMQKDMRKRRKEGVEFYTIGYAIYQLKDE-- 350
WTN Q+R+K + + + +V LMQK+ RK RK G +TIG+AIY++ E
Sbjct: 455 WTNPQYRLKLLEEDDDPDDSEVICSFLVALMQKNRRKDRKLGANLFTIGFAIYEVPKEMH 514
Query: 351 -NQGPLDVNFFKYNASVAKAPSFINLRE 431
N+ L +FF YNAS A++ ++IN+RE
Sbjct: 515 GNKQHLQKDFFLYNASKARSKTYINMRE 542
Score = 38.5 bits (88), Expect = 0.025
Identities = 21/47 (44%), Positives = 27/47 (57%)
Frame = +2
Query: 374 LFQVQRIGSKSAFIYQSSRECVDVTNLPPGTYVIVPSTFEPNQESCF 514
L+ + SK+ Y + RE LPP YVIVPST+EP+QE F
Sbjct: 526 LYNASKARSKT---YINMREVSQRFRLPPSEYVIVPSTYEPHQEGEF 569
Score = 36.2 bits (82), Expect = 0.12
Identities = 19/44 (43%), Positives = 28/44 (63%)
Frame = +2
Query: 656 KFAGQDLEIDAYELQDILNTAFKKGADGKYFKFDGFSIETSKSM 787
+ AG D+EI A EL+++LNT K D K GF++E+ +SM
Sbjct: 660 QIAGDDMEICADELKNVLNTVVNKHKD---LKTQGFTLESCRSM 700
Score = 35.4 bits (80), Expect = 0.21
Identities = 14/39 (35%), Positives = 23/39 (58%)
Frame = +3
Query: 759 GLALKHQKVWVAMMDYDQSGKLGFDEFKVLWTDLRLWKE 875
G L+ + +A+MD D SG+L EF LW ++ W++
Sbjct: 691 GFTLESCRSMIALMDTDGSGRLNLQEFHHLWKKIKAWQK 729
>sp|Q64691|CAN3_MOUSE Calpain-3 (Calpain L3) (Calpain p94) (Calcium-activated neutral
proteinase 3) (CANP 3) (Muscle-specific
calcium-activated neutral protease 3)
Length = 821
Score = 119 bits (298), Expect = 1e-26
Identities = 64/148 (43%), Positives = 91/148 (61%), Gaps = 5/148 (3%)
Frame = +3
Query: 3 SFQDFVKNFEKMEICHLGPQSLESDQLGGKPKSRWEMCLEIGEWKNRLNAGGCRNFLDTF 182
S+ DFV +F K+EIC+L +LESD+L W + + G W +AGGCRNF DTF
Sbjct: 400 SYDDFVYHFTKLEICNLTADALESDKL-----QTWTVSVNEGRWVRGCSAGGCRNFPDTF 454
Query: 183 WTNSQFRVKXXXXXXXXXXN--LGTIIVGLMQKDMRKRRKEGVEFYTIGYAIYQLKDE-- 350
WTN Q+R+K + + + +V LMQK+ RK RK G +TIG+AIY++ E
Sbjct: 455 WTNPQYRLKLLEEDDDPEDSEVICSFLVALMQKNRRKDRKLGANLFTIGFAIYEVPKEMH 514
Query: 351 -NQGPLDVNFFKYNASVAKAPSFINLRE 431
N+ L +FF YNAS A++ ++IN+RE
Sbjct: 515 GNKQHLQKDFFLYNASKARSKTYINMRE 542
Score = 38.5 bits (88), Expect = 0.025
Identities = 21/47 (44%), Positives = 27/47 (57%)
Frame = +2
Query: 374 LFQVQRIGSKSAFIYQSSRECVDVTNLPPGTYVIVPSTFEPNQESCF 514
L+ + SK+ Y + RE LPP YVIVPST+EP+QE F
Sbjct: 526 LYNASKARSKT---YINMREVSQRFRLPPSEYVIVPSTYEPHQEGEF 569
Score = 36.2 bits (82), Expect = 0.12
Identities = 19/44 (43%), Positives = 28/44 (63%)
Frame = +2
Query: 656 KFAGQDLEIDAYELQDILNTAFKKGADGKYFKFDGFSIETSKSM 787
+ AG D+EI A EL+++LNT K D K GF++E+ +SM
Sbjct: 660 QIAGDDMEICADELKNVLNTVVNKHKD---LKTQGFTLESCRSM 700
Score = 35.4 bits (80), Expect = 0.21
Identities = 14/39 (35%), Positives = 23/39 (58%)
Frame = +3
Query: 759 GLALKHQKVWVAMMDYDQSGKLGFDEFKVLWTDLRLWKE 875
G L+ + +A+MD D SG+L EF LW ++ W++
Sbjct: 691 GFTLESCRSMIALMDTDGSGRLNLQEFHHLWKKIKAWQK 729
>sp|P20807|CAN3_HUMAN Calpain-3 (Calpain L3) (Calpain p94) (Calcium-activated neutral
proteinase 3) (CANP 3) (Muscle-specific
calcium-activated neutral protease 3) (nCL-1)
Length = 821
Score = 118 bits (296), Expect = 2e-26
Identities = 62/148 (41%), Positives = 92/148 (62%), Gaps = 5/148 (3%)
Frame = +3
Query: 3 SFQDFVKNFEKMEICHLGPQSLESDQLGGKPKSRWEMCLEIGEWKNRLNAGGCRNFLDTF 182
S++DF+ +F K+EIC+L +L+SD+L W + + G W +AGGCRNF DTF
Sbjct: 400 SYEDFIYHFTKLEICNLTADALQSDKL-----QTWTVSVNEGRWVRGCSAGGCRNFPDTF 454
Query: 183 WTNSQFRVKXXXXXXXXXXN--LGTIIVGLMQKDMRKRRKEGVEFYTIGYAIYQLKDE-- 350
WTN Q+R+K + + + +V LMQK+ RK RK G +TIG+AIY++ E
Sbjct: 455 WTNPQYRLKLLEEDDDPDDSEVICSFLVALMQKNRRKDRKLGASLFTIGFAIYEVPKEMH 514
Query: 351 -NQGPLDVNFFKYNASVAKAPSFINLRE 431
N+ L +FF YNAS A++ ++IN+RE
Sbjct: 515 GNKQHLQKDFFLYNASKARSKTYINMRE 542
Score = 46.2 bits (108), Expect = 1e-04
Identities = 55/181 (30%), Positives = 75/181 (41%), Gaps = 43/181 (23%)
Frame = +2
Query: 374 LFQVQRIGSKSAFIYQSSRECVDVTNLPPGTYVIVPSTFEPNQESCFFS*EYF-LRNLMN 550
L+ + SK+ Y + RE LPP YVIVPST+EP+QE F + RNL
Sbjct: 526 LYNASKARSKT---YINMREVSQRFRLPPSEYVIVPSTYEPHQEGEFILRVFSEKRNLSE 582
Query: 551 QV-NSMS---------KRPWFLQS-------------------------QQKQSLQPMMH 625
+V N++S +P S +QKQS QP
Sbjct: 583 EVENTISVDRPVKKKKTKPIIFVSDRANSNKELGVDQESEEGKGKTSPDKQKQSPQPQPG 642
Query: 626 K*LL*EIHLIKF-------AGQDLEIDAYELQDILNTAFKKGADGKYFKFDGFSIETSKS 784
+F AG D+EI A EL+ +LNT K D K GF++E+ +S
Sbjct: 643 SSDQESEEQQQFRNIFKQIAGDDMEICADELKKVLNTVVNKHKD---LKTHGFTLESCRS 699
Query: 785 M 787
M
Sbjct: 700 M 700
Score = 37.0 bits (84), Expect = 0.072
Identities = 15/39 (38%), Positives = 23/39 (58%)
Frame = +3
Query: 759 GLALKHQKVWVAMMDYDQSGKLGFDEFKVLWTDLRLWKE 875
G L+ + +A+MD D SGKL EF LW ++ W++
Sbjct: 691 GFTLESCRSMIALMDTDGSGKLNLQEFHHLWNKIKAWQK 729
>sp|Q9TTH8|CAN3_SHEEP Calpain-3 (Calpain L3) (Calpain p94) (Calcium-activated neutral
proteinase 3) (CANP 3) (Muscle-specific
calcium-activated neutral protease 3) (nCL-1)
Length = 822
Score = 118 bits (296), Expect = 2e-26
Identities = 63/148 (42%), Positives = 91/148 (61%), Gaps = 5/148 (3%)
Frame = +3
Query: 3 SFQDFVKNFEKMEICHLGPQSLESDQLGGKPKSRWEMCLEIGEWKNRLNAGGCRNFLDTF 182
S+ DF+ +F K+EIC+L +LESD+L W + + G W +AGGCRNF DTF
Sbjct: 401 SYDDFIYHFTKLEICNLTADALESDKL-----QTWTVSVNEGRWVRGCSAGGCRNFPDTF 455
Query: 183 WTNSQFRVKXXXXXXXXXXN--LGTIIVGLMQKDMRKRRKEGVEFYTIGYAIYQLKDE-- 350
WTN Q+R+K + + + +V LMQK+ RK RK G +TIG+AIY++ E
Sbjct: 456 WTNPQYRLKLLEEDDDPDDSEVICSFLVALMQKNRRKDRKLGANLFTIGFAIYEVPKEMH 515
Query: 351 -NQGPLDVNFFKYNASVAKAPSFINLRE 431
N+ L +FF YNAS A++ ++IN+RE
Sbjct: 516 GNKQHLQKDFFLYNASKARSRTYINMRE 543
Score = 43.9 bits (102), Expect = 6e-04
Identities = 48/167 (28%), Positives = 71/167 (42%), Gaps = 43/167 (25%)
Frame = +2
Query: 416 YQSSRECVDVTNLPPGTYVIVPSTFEPNQESCFFS*EYF-LRNLMNQV-NSMS------- 568
Y + RE + LPP YVIVPST+EP+QE F + RNL +V N++S
Sbjct: 538 YINMREVSERFRLPPSEYVIVPSTYEPHQEGEFILRVFSEKRNLSEEVENTISVDRPVKK 597
Query: 569 KRPWFL-------------------------QSQQKQSLQPMMHK*LL*EIH-------- 649
K+P + S KQ+ P + + +
Sbjct: 598 KKPKPIIFGSDRANSNKELGVDQESEEGKDNTSPDKQAKSPQLKPGNIDQESKEQRQFRN 657
Query: 650 -LIKFAGQDLEIDAYELQDILNTAFKKGADGKYFKFDGFSIETSKSM 787
+ AG D+EI A EL+++LN K D K GF++E+ +SM
Sbjct: 658 IFRQIAGDDMEICADELKNVLNRVVNKHKD---LKTQGFTLESCRSM 701
Score = 35.4 bits (80), Expect = 0.21
Identities = 14/39 (35%), Positives = 23/39 (58%)
Frame = +3
Query: 759 GLALKHQKVWVAMMDYDQSGKLGFDEFKVLWTDLRLWKE 875
G L+ + +A+MD D SG+L EF LW ++ W++
Sbjct: 692 GFTLESCRSMIALMDTDGSGRLNLQEFHHLWKKIKTWQK 730
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 96,230,744
Number of Sequences: 369166
Number of extensions: 1855589
Number of successful extensions: 4964
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 4581
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 4855
length of database: 68,354,980
effective HSP length: 110
effective length of database: 48,034,130
effective search space used: 8694177530
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)