Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_027_J01
(815 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P43236|CATK_RABIT Cathepsin K precursor (OC-2 protein) 253 4e-67
sp|Q9GLE3|CATK_PIG Cathepsin K precursor 252 8e-67
sp|P61277|CATK_MACMU Cathepsin K precursor >gi|47117667|sp|... 250 4e-66
sp|Q9GL24|CATL_CANFA Cathepsin L precursor [Contains: Cathe... 249 8e-66
sp|O35186|CATK_RAT Cathepsin K precursor 249 8e-66
sp|P07711|CATL_HUMAN Cathepsin L precursor (Major excreted ... 247 2e-65
sp|O60911|CATL2_HUMAN Cathepsin L2 precursor (Cathepsin V) ... 247 2e-65
sp|P43235|CATK_HUMAN Cathepsin K precursor (Cathepsin O) (C... 247 3e-65
sp|P55097|CATK_MOUSE Cathepsin K precursor 246 7e-65
sp|Q28944|CATL_PIG Cathepsin L precursor [Contains: Catheps... 246 7e-65
>sp|P43236|CATK_RABIT Cathepsin K precursor (OC-2 protein)
Length = 329
Score = 253 bits (646), Expect = 4e-67
Identities = 129/260 (49%), Positives = 170/260 (65%), Gaps = 4/260 (1%)
Frame = +3
Query: 45 LNDDWESYKIKFGKKYES-LNEISRRLIWESNLKYIQKHNIESDLGKHTYTLGLNHFADM 221
L+ WE +K + K+Y S ++EISRRLIWE NLK+I HN+E+ LG HTY L +NH DM
Sbjct: 22 LDTQWELWKKTYSKQYNSKVDEISRRLIWEKNLKHISIHNLEASLGVHTYELAMNHLGDM 81
Query: 222 TNEEFRAKY--LSVPPSRKKISTVFMAPKNMGKLPDTVDWRTEGYVTPVKNQEQCGSCWS 395
T+EE K L VPPSR + P G+ PD++D+R +GYVTPVKNQ QCGSCW+
Sbjct: 82 TSEEVVQKMTGLKVPPSRSHSNDTLYIPDWEGRTPDSIDYRKKGYVTPVKNQGQCGSCWA 141
Query: 396 FSATGSLEGQHFRKTGNLTSFSEQQLVDXXXXXXXXXXXXXLMDNAFEYIEKF-GIESED 572
FS+ G+LEGQ +KTG L + S Q LVD M NAF+Y+++ GI+SED
Sbjct: 142 FSSVGALEGQLKKKTGKLLNLSPQNLVDCVSENYGCGGGY--MTNAFQYVQRNRGIDSED 199
Query: 573 AYPYTAEDGTCLYDKSKVVGSCTGYVDIPGGSETSLATAAATVGPISVAIDASNYSFQLY 752
AYPY +D +C+Y+ + C GY +IP G+E +L A A VGP+SVAIDAS SFQ Y
Sbjct: 200 AYPYVGQDESCMYNPTGKAAKCRGYREIPEGNEKALKRAVARVGPVSVAIDASLTSFQFY 259
Query: 753 KSGIYNEPDCSSTQLDHGVL 812
G+Y + +CSS ++H VL
Sbjct: 260 SKGVYYDENCSSDNVNHAVL 279
>sp|Q9GLE3|CATK_PIG Cathepsin K precursor
Length = 330
Score = 252 bits (644), Expect = 8e-67
Identities = 129/260 (49%), Positives = 169/260 (65%), Gaps = 4/260 (1%)
Frame = +3
Query: 45 LNDDWESYKIKFGKKYES-LNEISRRLIWESNLKYIQKHNIESDLGKHTYTLGLNHFADM 221
L+ WE +K + K+Y S ++EISRRLIWE NLK+I HN+E+ LG HTY L +NH DM
Sbjct: 23 LDTQWELWKKTYRKQYNSKVDEISRRLIWEKNLKHISIHNLEASLGVHTYELAMNHLGDM 82
Query: 222 TNEEFRAKY--LSVPPSRKKISTVFMAPKNMGKLPDTVDWRTEGYVTPVKNQEQCGSCWS 395
T+EE K L VPPS + + P G+ PD++D+R +GYVTPVKNQ QCGSCW+
Sbjct: 83 TSEEVVQKMTGLKVPPSHSRSNDTLYIPDWEGRTPDSIDYRKKGYVTPVKNQGQCGSCWA 142
Query: 396 FSATGSLEGQHFRKTGNLTSFSEQQLVDXXXXXXXXXXXXXLMDNAFEYIEKF-GIESED 572
FS+ G+LEGQ +KTG L + S Q LVD M NAF+Y++K GI+SED
Sbjct: 143 FSSVGALEGQLKKKTGKLLNLSPQNLVDCVSENDGCGGGY--MTNAFQYVQKNRGIDSED 200
Query: 573 AYPYTAEDGTCLYDKSKVVGSCTGYVDIPGGSETSLATAAATVGPISVAIDASNYSFQLY 752
AYPY +D C+Y+ + C GY +IP G+E +L A A VGP+SVAIDAS SFQ Y
Sbjct: 201 AYPYVGQDENCMYNPTGKAAKCRGYREIPEGNEKALKRAVARVGPVSVAIDASLTSFQFY 260
Query: 753 KSGIYNEPDCSSTQLDHGVL 812
G+Y + +C+S L+H VL
Sbjct: 261 SKGVYYDENCNSDNLNHAVL 280
>sp|P61277|CATK_MACMU Cathepsin K precursor
sp|P61276|CATK_MACFA Cathepsin K precursor
Length = 329
Score = 250 bits (638), Expect = 4e-66
Identities = 130/260 (50%), Positives = 167/260 (64%), Gaps = 4/260 (1%)
Frame = +3
Query: 45 LNDDWESYKIKFGKKYES-LNEISRRLIWESNLKYIQKHNIESDLGKHTYTLGLNHFADM 221
L+ WE +K K+Y S ++EISRRLIWE NLKYI HN+E+ LG HTY L +NH DM
Sbjct: 22 LDTHWELWKKTHRKQYNSKVDEISRRLIWEKNLKYISIHNLEASLGVHTYELAMNHLGDM 81
Query: 222 TNEEFRAKY--LSVPPSRKKISTVFMAPKNMGKLPDTVDWRTEGYVTPVKNQEQCGSCWS 395
TNEE K L VP S + + P G+ PD+VD+R +GYVTPVKNQ QCGSCW+
Sbjct: 82 TNEEVVQKMTGLKVPASHSRSNDTLYIPDWEGRAPDSVDYRKKGYVTPVKNQGQCGSCWA 141
Query: 396 FSATGSLEGQHFRKTGNLTSFSEQQLVDXXXXXXXXXXXXXLMDNAFEYIEKF-GIESED 572
FS+ G+LEGQ +KTG L + S Q LVD M NAF+Y++K GI+SED
Sbjct: 142 FSSVGALEGQLKKKTGKLLNLSPQNLVDCVSENDGCGGGY--MTNAFQYVQKNRGIDSED 199
Query: 573 AYPYTAEDGTCLYDKSKVVGSCTGYVDIPGGSETSLATAAATVGPISVAIDASNYSFQLY 752
AYPY ++ +C+Y+ + C GY +IP G+E +L A A VGP+SVAIDAS SFQ Y
Sbjct: 200 AYPYVGQEESCMYNPTGKAAKCRGYREIPEGNEKALKRAVARVGPVSVAIDASLTSFQFY 259
Query: 753 KSGIYNEPDCSSTQLDHGVL 812
G+Y + C+S L+H VL
Sbjct: 260 SKGVYYDESCNSDNLNHAVL 279
>sp|Q9GL24|CATL_CANFA Cathepsin L precursor [Contains: Cathepsin L heavy chain; Cathepsin
L light chain]
Length = 333
Score = 249 bits (635), Expect = 8e-66
Identities = 135/273 (49%), Positives = 166/273 (60%), Gaps = 2/273 (0%)
Frame = +3
Query: 3 VAHVAPHKLTVNSELNDDWESYKIKFGKKYESLNEISRRLIWESNLKYIQKHNIESDLGK 182
+A AP + LN W +K + Y E RR +WE N+K I+ HN E GK
Sbjct: 14 IASAAPK---FDQSLNAQWYQWKATHRRLYGMNEEGWRRAVWEKNMKMIELHNREYSQGK 70
Query: 183 HTYTLGLNHFADMTNEEFRAKYLSVPPSRKKISTVFMAPKNMGKLPDTVDWRTEGYVTPV 362
H +T+ +N F DMTNEEFR + K +F P ++P +VDWR +GYVTPV
Sbjct: 71 HGFTMAMNAFGDMTNEEFRQVMNGFQNQKHKKGKMFQEPL-FAEIPKSVDWREKGYVTPV 129
Query: 363 KNQEQCGSCWSFSATGSLEGQHFRKTGNLTSFSEQQLVDXXXXXXXXXXXXXLMDNAFEY 542
KNQ QCGSCW+FSATG+LEGQ FRKTG L S SEQ LVD LMDNAF Y
Sbjct: 130 KNQGQCGSCWAFSATGALEGQMFRKTGKLVSLSEQNLVDCSRAQGNEGCNGGLMDNAFRY 189
Query: 543 I-EKFGIESEDAYPYTAED-GTCLYDKSKVVGSCTGYVDIPGGSETSLATAAATVGPISV 716
+ + G++SE++YPY D TC Y + TG+VD+P E +L A AT+GPISV
Sbjct: 190 VKDNGGLDSEESYPYLGRDTETCNYKPECSAANDTGFVDLP-QREKALMKAVATLGPISV 248
Query: 717 AIDASNYSFQLYKSGIYNEPDCSSTQLDHGVLV 815
AIDA + SFQ YKSGIY +PDCSS LDHGVLV
Sbjct: 249 AIDAGHQSFQFYKSGIYFDPDCSSKDLDHGVLV 281
>sp|O35186|CATK_RAT Cathepsin K precursor
Length = 329
Score = 249 bits (635), Expect = 8e-66
Identities = 129/272 (47%), Positives = 172/272 (63%), Gaps = 4/272 (1%)
Frame = +3
Query: 12 VAPHKLTVNSELNDDWESYKIKFGKKYES-LNEISRRLIWESNLKYIQKHNIESDLGKHT 188
V L+ L+ WE +K GK+Y S ++EISRRLIWE NLK I HN+E+ LG HT
Sbjct: 11 VVSFALSPEETLDTQWELWKKTHGKQYNSKVDEISRRLIWEKNLKKISVHNLEASLGAHT 70
Query: 189 YTLGLNHFADMTNEEFRAKY--LSVPPSRKKISTVFMAPKNMGKLPDTVDWRTEGYVTPV 362
Y L +NH DMT+EE K L VPPSR + P+ G++PD++D+R +GYVTPV
Sbjct: 71 YELAMNHLGDMTSEEVVQKMTGLRVPPSRSFSNDTLYTPEWEGRVPDSIDYRKKGYVTPV 130
Query: 363 KNQEQCGSCWSFSATGSLEGQHFRKTGNLTSFSEQQLVDXXXXXXXXXXXXXLMDNAFEY 542
KNQ QCGSCW+FS+ G+LEGQ +KTG L + S Q LVD M AF+Y
Sbjct: 131 KNQGQCGSCWAFSSAGALEGQLKKKTGKLLALSPQNLVD--CVSENYGCGGGYMTTAFQY 188
Query: 543 IEK-FGIESEDAYPYTAEDGTCLYDKSKVVGSCTGYVDIPGGSETSLATAAATVGPISVA 719
+++ GI+SEDAYPY +D +C+Y+ + C GY +IP G+E +L A A VGP+SV+
Sbjct: 189 VQQNGGIDSEDAYPYVGQDESCMYNATAKAAKCRGYREIPVGNEKALKRAVARVGPVSVS 248
Query: 720 IDASNYSFQLYKSGIYNEPDCSSTQLDHGVLV 815
IDAS SFQ Y G+Y + +C ++H VLV
Sbjct: 249 IDASLTSFQFYSRGVYYDENCDRDNVNHAVLV 280
>sp|P07711|CATL_HUMAN Cathepsin L precursor (Major excreted protein) (MEP) [Contains:
Cathepsin L heavy chain; Cathepsin L light chain]
Length = 333
Score = 247 bits (631), Expect = 2e-65
Identities = 132/269 (49%), Positives = 166/269 (61%), Gaps = 1/269 (0%)
Frame = +3
Query: 12 VAPHKLTVNSELNDDWESYKIKFGKKYESLNEISRRLIWESNLKYIQKHNIESDLGKHTY 191
+A LT + L W +K + Y E RR +WE N+K I+ HN E GKH++
Sbjct: 14 IASATLTFDHSLEAQWTKWKAMHNRLYGMNEEGWRRAVWEKNMKMIELHNQEYREGKHSF 73
Query: 192 TLGLNHFADMTNEEFRAKYLSVPPSRKKISTVFMAPKNMGKLPDTVDWRTEGYVTPVKNQ 371
T+ +N F DMT+EEFR + + VF P + P +VDWR +GYVTPVKNQ
Sbjct: 74 TMAMNAFGDMTSEEFRQVMNGFQNRKPRKGKVFQEPL-FYEAPRSVDWREKGYVTPVKNQ 132
Query: 372 EQCGSCWSFSATGSLEGQHFRKTGNLTSFSEQQLVDXXXXXXXXXXXXXLMDNAFEYI-E 548
QCGSCW+FSATG+LEGQ FRKTG L S SEQ LVD LMD AF+Y+ +
Sbjct: 133 GQCGSCWAFSATGALEGQMFRKTGRLISLSEQNLVDCSGPQGNEGCNGGLMDYAFQYVQD 192
Query: 549 KFGIESEDAYPYTAEDGTCLYDKSKVVGSCTGYVDIPGGSETSLATAAATVGPISVAIDA 728
G++SE++YPY A + +C Y+ V + TG+VDIP E +L A ATVGPISVAIDA
Sbjct: 193 NGGLDSEESYPYEATEESCKYNPKYSVANDTGFVDIP-KQEKALMKAVATVGPISVAIDA 251
Query: 729 SNYSFQLYKSGIYNEPDCSSTQLDHGVLV 815
+ SF YK GIY EPDCSS +DHGVLV
Sbjct: 252 GHESFLFYKEGIYFEPDCSSEDMDHGVLV 280
>sp|O60911|CATL2_HUMAN Cathepsin L2 precursor (Cathepsin V) (Cathepsin U)
Length = 334
Score = 247 bits (631), Expect = 2e-65
Identities = 130/261 (49%), Positives = 161/261 (61%), Gaps = 1/261 (0%)
Frame = +3
Query: 36 NSELNDDWESYKIKFGKKYESLNEISRRLIWESNLKYIQKHNIESDLGKHTYTLGLNHFA 215
+ L+ W +K + Y + E RR +WE N+K I+ HN E GKH +T+ +N F
Sbjct: 22 DQNLDTKWYQWKATHRRLYGANEEGWRRAVWEKNMKMIELHNGEYSQGKHGFTMAMNAFG 81
Query: 216 DMTNEEFRAKYLSVPPSRKKISTVFMAPKNMGKLPDTVDWRTEGYVTPVKNQEQCGSCWS 395
DMTNEEFR + + VF P + LP +VDWR +GYVTPVKNQ+QCGSCW+
Sbjct: 82 DMTNEEFRQMMGCFRNQKFRKGKVFREPLFLD-LPKSVDWRKKGYVTPVKNQKQCGSCWA 140
Query: 396 FSATGSLEGQHFRKTGNLTSFSEQQLVDXXXXXXXXXXXXXLMDNAFEYI-EKFGIESED 572
FSATG+LEGQ FRKTG L S SEQ LVD M AF+Y+ E G++SE+
Sbjct: 141 FSATGALEGQMFRKTGKLVSLSEQNLVDCSRPQGNQGCNGGFMARAFQYVKENGGLDSEE 200
Query: 573 AYPYTAEDGTCLYDKSKVVGSCTGYVDIPGGSETSLATAAATVGPISVAIDASNYSFQLY 752
+YPY A D C Y V + TG+ + G E +L A ATVGPISVA+DA + SFQ Y
Sbjct: 201 SYPYVAVDEICKYRPENSVANDTGFTVVAPGKEKALMKAVATVGPISVAMDAGHSSFQFY 260
Query: 753 KSGIYNEPDCSSTQLDHGVLV 815
KSGIY EPDCSS LDHGVLV
Sbjct: 261 KSGIYFEPDCSSKNLDHGVLV 281
>sp|P43235|CATK_HUMAN Cathepsin K precursor (Cathepsin O) (Cathepsin X) (Cathepsin O2)
Length = 329
Score = 247 bits (630), Expect = 3e-65
Identities = 128/260 (49%), Positives = 168/260 (64%), Gaps = 4/260 (1%)
Frame = +3
Query: 45 LNDDWESYKIKFGKKYES-LNEISRRLIWESNLKYIQKHNIESDLGKHTYTLGLNHFADM 221
L+ WE +K K+Y + ++EISRRLIWE NLKYI HN+E+ LG HTY L +NH DM
Sbjct: 22 LDTHWELWKKTHRKQYNNKVDEISRRLIWEKNLKYISIHNLEASLGVHTYELAMNHLGDM 81
Query: 222 TNEEFRAKY--LSVPPSRKKISTVFMAPKNMGKLPDTVDWRTEGYVTPVKNQEQCGSCWS 395
T+EE K L VP S + + P+ G+ PD+VD+R +GYVTPVKNQ QCGSCW+
Sbjct: 82 TSEEVVQKMTGLKVPLSHSRSNDTLYIPEWEGRAPDSVDYRKKGYVTPVKNQGQCGSCWA 141
Query: 396 FSATGSLEGQHFRKTGNLTSFSEQQLVDXXXXXXXXXXXXXLMDNAFEYIEKF-GIESED 572
FS+ G+LEGQ +KTG L + S Q LVD M NAF+Y++K GI+SED
Sbjct: 142 FSSVGALEGQLKKKTGKLLNLSPQNLVDCVSENDGCGGGY--MTNAFQYVQKNRGIDSED 199
Query: 573 AYPYTAEDGTCLYDKSKVVGSCTGYVDIPGGSETSLATAAATVGPISVAIDASNYSFQLY 752
AYPY ++ +C+Y+ + C GY +IP G+E +L A A VGP+SVAIDAS SFQ Y
Sbjct: 200 AYPYVGQEESCMYNPTGKAAKCRGYREIPEGNEKALKRAVARVGPVSVAIDASLTSFQFY 259
Query: 753 KSGIYNEPDCSSTQLDHGVL 812
G+Y + C+S L+H VL
Sbjct: 260 SKGVYYDESCNSDNLNHAVL 279
>sp|P55097|CATK_MOUSE Cathepsin K precursor
Length = 329
Score = 246 bits (627), Expect = 7e-65
Identities = 127/267 (47%), Positives = 170/267 (63%), Gaps = 4/267 (1%)
Frame = +3
Query: 27 LTVNSELNDDWESYKIKFGKKYES-LNEISRRLIWESNLKYIQKHNIESDLGKHTYTLGL 203
L+ L+ WE +K K+Y S ++EISRRLIWE NLK I HN+E+ LG HTY L +
Sbjct: 16 LSPEEMLDTQWELWKKTHQKQYNSKVDEISRRLIWEKNLKQISAHNLEASLGVHTYELAM 75
Query: 204 NHFADMTNEEFRAKY--LSVPPSRKKISTVFMAPKNMGKLPDTVDWRTEGYVTPVKNQEQ 377
NH DMT+EE K L +PPSR + P+ G++PD++D+R +GYVTPVKNQ Q
Sbjct: 76 NHLGDMTSEEVVQKMTGLRIPPSRSYSNDTLYTPEWEGRVPDSIDYRKKGYVTPVKNQGQ 135
Query: 378 CGSCWSFSATGSLEGQHFRKTGNLTSFSEQQLVDXXXXXXXXXXXXXLMDNAFEYIEK-F 554
CGSCW+FS+ G+LEGQ +KTG L + S Q LVD M AF+Y+++
Sbjct: 136 CGSCWAFSSAGALEGQLKKKTGKLLALSPQNLVD--CVTENYGCGGGYMTTAFQYVQQNG 193
Query: 555 GIESEDAYPYTAEDGTCLYDKSKVVGSCTGYVDIPGGSETSLATAAATVGPISVAIDASN 734
GI+SEDAYPY +D +C+Y+ + C GY +IP G+E +L A A VGPISV+IDAS
Sbjct: 194 GIDSEDAYPYVGQDESCMYNATAKAAKCRGYREIPVGNEKALKRAVARVGPISVSIDASL 253
Query: 735 YSFQLYKSGIYNEPDCSSTQLDHGVLV 815
SFQ Y G+Y + +C ++H VLV
Sbjct: 254 ASFQFYSRGVYYDENCDRDNVNHAVLV 280
>sp|Q28944|CATL_PIG Cathepsin L precursor [Contains: Cathepsin L heavy chain; Cathepsin
L light chain]
Length = 334
Score = 246 bits (627), Expect = 7e-65
Identities = 134/273 (49%), Positives = 169/273 (61%), Gaps = 2/273 (0%)
Frame = +3
Query: 3 VAHVAPHKLTVNSELNDDWESYKIKFGKKYESLNEISRRLIWESNLKYIQKHNIESDLGK 182
+A AP ++ L+ DW +K G+ Y E RR +WE N+K I+ HN E GK
Sbjct: 14 IASAAPK---LDQNLDADWYKWKATHGRLYGMNEEGWRRAVWEKNMKMIELHNQEYSQGK 70
Query: 183 HTYTLGLNHFADMTNEEFRAKYLSVPPSRKKISTVFMAPKNMGKLPDTVDWRTEGYVTPV 362
H +++ +N F DMTNEEFR + K VF + ++P +VDWR +GYVT V
Sbjct: 71 HGFSMAMNAFGDMTNEEFRQVMNGFQNQKHKKGKVFHESLVL-EVPKSVDWREKGYVTAV 129
Query: 363 KNQEQCGSCWSFSATGSLEGQHFRKTGNLTSFSEQQLVDXXXXXXXXXXXXXLMDNAFEY 542
KNQ QCGSCW+FSATG+LEGQ FRKTG L S SEQ LVD LMDNAF+Y
Sbjct: 130 KNQGQCGSCWAFSATGALEGQMFRKTGKLVSLSEQNLVDCSRPQGNQGCNGGLMDNAFQY 189
Query: 543 I-EKFGIESEDAYPYTA-EDGTCLYDKSKVVGSCTGYVDIPGGSETSLATAAATVGPISV 716
+ + G+++E++YPY E +C Y + TG+VDIP E +L A ATVGPISV
Sbjct: 190 VKDNGGLDTEESYPYLGRETNSCTYKPECSAANDTGFVDIP-QREKALMKAVATVGPISV 248
Query: 717 AIDASNYSFQLYKSGIYNEPDCSSTQLDHGVLV 815
AIDA + SFQ YKSGIY +PDCSS LDHGVLV
Sbjct: 249 AIDAGHSSFQFYKSGIYYDPDCSSKDLDHGVLV 281
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 88,465,181
Number of Sequences: 369166
Number of extensions: 1768944
Number of successful extensions: 5897
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 5337
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 5527
length of database: 68,354,980
effective HSP length: 109
effective length of database: 48,218,865
effective search space used: 7811456130
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)