Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_027_I21
(677 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q26636|CATL_SARPE Cathepsin L precursor [Contains: Cathe... 197 2e-50
sp|P25782|CYSP2_HOMAM Digestive cysteine proteinase 2 precu... 192 9e-49
sp|Q95029|CATL_DROME Cathepsin L precursor (Cysteine protei... 190 3e-48
sp|P07154|CATL_RAT Cathepsin L precursor (Major excreted pr... 189 4e-48
sp|Q10991|CATL_SHEEP Cathepsin L [Contains: Cathepsin L hea... 188 1e-47
sp|P06797|CATL_MOUSE Cathepsin L precursor (Major excreted ... 185 8e-47
sp|P07711|CATL_HUMAN Cathepsin L precursor (Major excreted ... 181 1e-45
sp|O60911|CATL2_HUMAN Cathepsin L2 precursor (Cathepsin V) ... 181 1e-45
sp|Q9GL24|CATL_CANFA Cathepsin L precursor [Contains: Cathe... 180 3e-45
sp|P25975|CATL_BOVIN Cathepsin L precursor [Contains: Cathe... 180 3e-45
>sp|Q26636|CATL_SARPE Cathepsin L precursor [Contains: Cathepsin L heavy chain; Cathepsin
L light chain]
Length = 339
Score = 197 bits (501), Expect = 2e-50
Identities = 96/178 (53%), Positives = 122/178 (68%), Gaps = 2/178 (1%)
Frame = +1
Query: 76 KQEI*LAFQKQQLVDXXXXXXXXXXXXXLMDNAFEYI-EKFGIESEDAYPYTAEDGTCLY 252
K + ++ +Q LVD LMDNAF YI + GI++E +YPY D +C +
Sbjct: 162 KAGVLVSLSEQNLVDCSTKYGNNGCNGGLMDNAFRYIKDNGGIDTEKSYPYEGIDDSCHF 221
Query: 253 DKSKVVGSCTGYVDIPGGSETSLATAAATVGPISVAIDASNYSFQLYKSGIYNEPDCSST 432
+K+ + + TG+VDIP G E + A AT+GP+SVAIDAS+ SFQLY G+YNEP+C
Sbjct: 222 NKATIGATDTGFVDIPEGDEEKMKKAVATMGPVSVAIDASHESFQLYSEGVYNEPECDEQ 281
Query: 433 QLDHGVLVVGYGT-EDGSNYWLVKNSWGTVWGIDGYIKMSKDANNQCGIATMASYPLV 603
LDHGVLVVGYGT E G +YWLVKNSWGT WG GYIKM+++ NNQCGIAT +SYP V
Sbjct: 282 NLDHGVLVVGYGTDESGMDYWLVKNSWGTTWGEQGYIKMARNQNNQCGIATASSYPTV 339
Score = 57.0 bits (136), Expect = 4e-08
Identities = 24/34 (70%), Positives = 28/34 (82%)
Frame = +3
Query: 3 KNQEQCGSCWSFSATGSLEGQHFRKTGNLTSFSE 104
K+Q CGSCW+FS+TG+LEGQHFRK G L S SE
Sbjct: 138 KDQGHCGSCWAFSSTGALEGQHFRKAGVLVSLSE 171
>sp|P25782|CYSP2_HOMAM Digestive cysteine proteinase 2 precursor
Length = 323
Score = 192 bits (487), Expect = 9e-49
Identities = 91/172 (52%), Positives = 118/172 (68%), Gaps = 1/172 (0%)
Frame = +1
Query: 91 LAFQKQQLVDXXXXXXXXXXXXXLMDNAFEYIE-KFGIESEDAYPYTAEDGTCLYDKSKV 267
++ +QQLVD M++AF+YI+ GI++E AYPY A DG+C +D + V
Sbjct: 152 ISLAEQQLVDCSRPYGPQGCNGGWMNDAFDYIKANNGIDTEAAYPYEARDGSCRFDSNSV 211
Query: 268 VGSCTGYVDIPGGSETSLATAAATVGPISVAIDASNYSFQLYKSGIYNEPDCSSTQLDHG 447
+C+G+ +I GSET L A +GPISV IDA++ SFQ Y SG+Y EP CS + LDH
Sbjct: 212 AATCSGHTNIASGSETGLQQAVRDIGPISVTIDAAHSSFQFYSSGVYYEPSCSPSYLDHA 271
Query: 448 VLVVGYGTEDGSNYWLVKNSWGTVWGIDGYIKMSKDANNQCGIATMASYPLV 603
VL VGYG+E G ++WLVKNSW T WG GYIKMS++ NN CGIAT+ASYPLV
Sbjct: 272 VLAVGYGSEGGQDFWLVKNSWATSWGDAGYIKMSRNRNNNCGIATVASYPLV 323
Score = 58.9 bits (141), Expect = 1e-08
Identities = 25/34 (73%), Positives = 29/34 (85%)
Frame = +3
Query: 3 KNQEQCGSCWSFSATGSLEGQHFRKTGNLTSFSE 104
K+Q QCGSCW+FS TGSLEGQHF KTG+L S +E
Sbjct: 123 KDQGQCGSCWAFSTTGSLEGQHFLKTGSLISLAE 156
>sp|Q95029|CATL_DROME Cathepsin L precursor (Cysteine proteinase 1) [Contains: Cathepsin
L heavy chain; Cathepsin L light chain]
Length = 341
Score = 190 bits (483), Expect = 3e-48
Identities = 94/178 (52%), Positives = 119/178 (66%), Gaps = 2/178 (1%)
Frame = +1
Query: 76 KQEI*LAFQKQQLVDXXXXXXXXXXXXXLMDNAFEYI-EKFGIESEDAYPYTAEDGTCLY 252
K + ++ +Q LVD LMDNAF YI + GI++E +YPY A D +C +
Sbjct: 164 KSGVLVSLSEQNLVDCSTKYGNNGCNGGLMDNAFRYIKDNGGIDTEKSYPYEAIDDSCHF 223
Query: 253 DKSKVVGSCTGYVDIPGGSETSLATAAATVGPISVAIDASNYSFQLYKSGIYNEPDCSST 432
+K V + G+ DIP G E +A A ATVGP+SVAIDAS+ SFQ Y G+YNEP C +
Sbjct: 224 NKGTVGATDRGFTDIPQGDEKKMAEAVATVGPVSVAIDASHESFQFYSEGVYNEPQCDAQ 283
Query: 433 QLDHGVLVVGYGT-EDGSNYWLVKNSWGTVWGIDGYIKMSKDANNQCGIATMASYPLV 603
LDHGVLVVG+GT E G +YWLVKNSWGT WG G+IKM ++ NQCGIA+ +SYPLV
Sbjct: 284 NLDHGVLVVGFGTDESGEDYWLVKNSWGTTWGDKGFIKMLRNKENQCGIASASSYPLV 341
Score = 57.4 bits (137), Expect = 3e-08
Identities = 24/34 (70%), Positives = 29/34 (85%)
Frame = +3
Query: 3 KNQEQCGSCWSFSATGSLEGQHFRKTGNLTSFSE 104
K+Q CGSCW+FS+TG+LEGQHFRK+G L S SE
Sbjct: 140 KDQGHCGSCWAFSSTGALEGQHFRKSGVLVSLSE 173
>sp|P07154|CATL_RAT Cathepsin L precursor (Major excreted protein) (MEP) (Cyclic
protein 2) (CP-2) [Contains: Cathepsin L heavy chain;
Cathepsin L light chain]
Length = 334
Score = 189 bits (481), Expect = 4e-48
Identities = 98/176 (55%), Positives = 120/176 (68%), Gaps = 5/176 (2%)
Frame = +1
Query: 91 LAFQKQQLVDXXXXXXXXXXXXXLMDNAFEYI-EKFGIESEDAYPYTAEDGTCLYDKSKV 267
++ +Q LVD LMD AF+YI E G++SE++YPY A+DG+C Y
Sbjct: 159 ISLSEQNLVDCSHDQGNQGCNGGLMDFAFQYIKENGGLDSEESYPYEAKDGSCKYRAEYA 218
Query: 268 VGSCTGYVDIPGGSETSLATAAATVGPISVAIDASNYSFQLYKSGIYNEPDCSSTQLDHG 447
V + TG+VDIP E +L A ATVGPISVA+DAS+ S Q Y SGIY EP+CSS LDHG
Sbjct: 219 VANDTGFVDIPQ-QEKALMKAVATVGPISVAMDASHPSLQFYSSGIYYEPNCSSKDLDHG 277
Query: 448 VLVVGYGTE----DGSNYWLVKNSWGTVWGIDGYIKMSKDANNQCGIATMASYPLV 603
VLVVGYG E + YWLVKNSWG WG+DGYIK++KD NN CG+AT ASYP+V
Sbjct: 278 VLVVGYGYEGTDSNKDKYWLVKNSWGKEWGMDGYIKIAKDRNNHCGLATAASYPIV 333
Score = 55.8 bits (133), Expect = 1e-07
Identities = 25/34 (73%), Positives = 27/34 (79%)
Frame = +3
Query: 3 KNQEQCGSCWSFSATGSLEGQHFRKTGNLTSFSE 104
KNQ QCGSCW+FSA+G LEGQ F KTG L S SE
Sbjct: 130 KNQGQCGSCWAFSASGCLEGQMFLKTGKLISLSE 163
>sp|Q10991|CATL_SHEEP Cathepsin L [Contains: Cathepsin L heavy chain; Cathepsin L light
chain]
Length = 217
Score = 188 bits (477), Expect = 1e-47
Identities = 98/173 (56%), Positives = 116/173 (67%), Gaps = 2/173 (1%)
Frame = +1
Query: 91 LAFQKQQLVDXXXXXXXXXXXXXLMDNAFEYI-EKFGIESEDAYPYTAEDGTCLYDKSKV 267
++ +Q LVD LMDNAF+YI E G++SE++YPY A D +C Y
Sbjct: 46 VSLSEQNLVDSSRPQGNQGCNGGLMDNAFQYIKENGGLDSEESYPYEATDTSCNYKPEYS 105
Query: 268 VGSCTGYVDIPGGSETSLATAAATVGPISVAIDASNYSFQLYKSGIYNEPDCSSTQLDHG 447
TG+VDIP E +L A ATVGPISVAIDA + SFQ YKSGIY +PDCSS LDHG
Sbjct: 106 AAKDTGFVDIPQ-REKALMKAVATVGPISVAIDAGHSSFQFYKSGIYYDPDCSSKDLDHG 164
Query: 448 VLVVGYGTEDGSN-YWLVKNSWGTVWGIDGYIKMSKDANNQCGIATMASYPLV 603
VLVVGYG E +N +W+VKNSWG WG GY+KM+KD NN CGIAT ASYP V
Sbjct: 165 VLVVGYGFEGTNNKFWIVKNSWGPEWGNKGYVKMAKDQNNHCGIATAASYPTV 217
Score = 61.2 bits (147), Expect = 2e-09
Identities = 27/34 (79%), Positives = 29/34 (85%)
Frame = +3
Query: 3 KNQEQCGSCWSFSATGSLEGQHFRKTGNLTSFSE 104
KNQ QCGSCW+FSATG+LEGQ FRKTG L S SE
Sbjct: 17 KNQGQCGSCWAFSATGALEGQMFRKTGKLVSLSE 50
>sp|P06797|CATL_MOUSE Cathepsin L precursor (Major excreted protein) (MEP) (p39 cysteine
proteinase) [Contains: Cathepsin L heavy chain;
Cathepsin L light chain]
Length = 334
Score = 185 bits (470), Expect = 8e-47
Identities = 95/176 (53%), Positives = 122/176 (69%), Gaps = 5/176 (2%)
Frame = +1
Query: 91 LAFQKQQLVDXXXXXXXXXXXXXLMDNAFEYI-EKFGIESEDAYPYTAEDGTCLYDKSKV 267
++ +Q LVD LMD AF+YI E G++SE++YPY A+DG+C Y
Sbjct: 159 ISLSEQNLVDCSHAQGNQGCNGGLMDFAFQYIKENGGLDSEESYPYEAKDGSCKYRAEFA 218
Query: 268 VGSCTGYVDIPGGSETSLATAAATVGPISVAIDASNYSFQLYKSGIYNEPDCSSTQLDHG 447
V + TG+VDIP E +L A ATVGPISVA+DAS+ S Q Y SGIY EP+CSS LDHG
Sbjct: 219 VANDTGFVDIPQ-QEKALMKAVATVGPISVAMDASHPSLQFYSSGIYYEPNCSSKNLDHG 277
Query: 448 VLVVGYGTE----DGSNYWLVKNSWGTVWGIDGYIKMSKDANNQCGIATMASYPLV 603
VL+VGYG E + + YWLVKNSWG+ WG++GYIK++KD +N CG+AT ASYP+V
Sbjct: 278 VLLVGYGYEGTDSNKNKYWLVKNSWGSEWGMEGYIKIAKDRDNHCGLATAASYPVV 333
Score = 55.8 bits (133), Expect = 1e-07
Identities = 25/34 (73%), Positives = 27/34 (79%)
Frame = +3
Query: 3 KNQEQCGSCWSFSATGSLEGQHFRKTGNLTSFSE 104
KNQ QCGSCW+FSA+G LEGQ F KTG L S SE
Sbjct: 130 KNQGQCGSCWAFSASGCLEGQMFLKTGKLISLSE 163
>sp|P07711|CATL_HUMAN Cathepsin L precursor (Major excreted protein) (MEP) [Contains:
Cathepsin L heavy chain; Cathepsin L light chain]
Length = 333
Score = 181 bits (460), Expect = 1e-45
Identities = 93/176 (52%), Positives = 116/176 (65%), Gaps = 5/176 (2%)
Frame = +1
Query: 91 LAFQKQQLVDXXXXXXXXXXXXXLMDNAFEYIE-KFGIESEDAYPYTAEDGTCLYDKSKV 267
++ +Q LVD LMD AF+Y++ G++SE++YPY A + +C Y+
Sbjct: 159 ISLSEQNLVDCSGPQGNEGCNGGLMDYAFQYVQDNGGLDSEESYPYEATEESCKYNPKYS 218
Query: 268 VGSCTGYVDIPGGSETSLATAAATVGPISVAIDASNYSFQLYKSGIYNEPDCSSTQLDHG 447
V + TG+VDIP E +L A ATVGPISVAIDA + SF YK GIY EPDCSS +DHG
Sbjct: 219 VANDTGFVDIPK-QEKALMKAVATVGPISVAIDAGHESFLFYKEGIYFEPDCSSEDMDHG 277
Query: 448 VLVVGYGTE----DGSNYWLVKNSWGTVWGIDGYIKMSKDANNQCGIATMASYPLV 603
VLVVGYG E D + YWLVKNSWG WG+ GY+KM+KD N CGIA+ ASYP V
Sbjct: 278 VLVVGYGFESTESDNNKYWLVKNSWGEEWGMGGYVKMAKDRRNHCGIASAASYPTV 333
Score = 60.8 bits (146), Expect = 3e-09
Identities = 27/34 (79%), Positives = 29/34 (85%)
Frame = +3
Query: 3 KNQEQCGSCWSFSATGSLEGQHFRKTGNLTSFSE 104
KNQ QCGSCW+FSATG+LEGQ FRKTG L S SE
Sbjct: 130 KNQGQCGSCWAFSATGALEGQMFRKTGRLISLSE 163
>sp|O60911|CATL2_HUMAN Cathepsin L2 precursor (Cathepsin V) (Cathepsin U)
Length = 334
Score = 181 bits (460), Expect = 1e-45
Identities = 93/176 (52%), Positives = 113/176 (64%), Gaps = 5/176 (2%)
Frame = +1
Query: 91 LAFQKQQLVDXXXXXXXXXXXXXLMDNAFEYI-EKFGIESEDAYPYTAEDGTCLYDKSKV 267
++ +Q LVD M AF+Y+ E G++SE++YPY A D C Y
Sbjct: 159 VSLSEQNLVDCSRPQGNQGCNGGFMARAFQYVKENGGLDSEESYPYVAVDEICKYRPENS 218
Query: 268 VGSCTGYVDIPGGSETSLATAAATVGPISVAIDASNYSFQLYKSGIYNEPDCSSTQLDHG 447
V + TG+ + G E +L A ATVGPISVA+DA + SFQ YKSGIY EPDCSS LDHG
Sbjct: 219 VANDTGFTVVAPGKEKALMKAVATVGPISVAMDAGHSSFQFYKSGIYFEPDCSSKNLDHG 278
Query: 448 VLVVGYGTE----DGSNYWLVKNSWGTVWGIDGYIKMSKDANNQCGIATMASYPLV 603
VLVVGYG E + S YWLVKNSWG WG +GY+K++KD NN CGIAT ASYP V
Sbjct: 279 VLVVGYGFEGANSNNSKYWLVKNSWGPEWGSNGYVKIAKDKNNHCGIATAASYPNV 334
Score = 62.4 bits (150), Expect = 1e-09
Identities = 27/34 (79%), Positives = 30/34 (88%)
Frame = +3
Query: 3 KNQEQCGSCWSFSATGSLEGQHFRKTGNLTSFSE 104
KNQ+QCGSCW+FSATG+LEGQ FRKTG L S SE
Sbjct: 130 KNQKQCGSCWAFSATGALEGQMFRKTGKLVSLSE 163
>sp|Q9GL24|CATL_CANFA Cathepsin L precursor [Contains: Cathepsin L heavy chain; Cathepsin
L light chain]
Length = 333
Score = 180 bits (456), Expect = 3e-45
Identities = 93/176 (52%), Positives = 116/176 (65%), Gaps = 5/176 (2%)
Frame = +1
Query: 91 LAFQKQQLVDXXXXXXXXXXXXXLMDNAFEYI-EKFGIESEDAYPYTAEDG-TCLYDKSK 264
++ +Q LVD LMDNAF Y+ + G++SE++YPY D TC Y
Sbjct: 159 VSLSEQNLVDCSRAQGNEGCNGGLMDNAFRYVKDNGGLDSEESYPYLGRDTETCNYKPEC 218
Query: 265 VVGSCTGYVDIPGGSETSLATAAATVGPISVAIDASNYSFQLYKSGIYNEPDCSSTQLDH 444
+ TG+VD+P E +L A AT+GPISVAIDA + SFQ YKSGIY +PDCSS LDH
Sbjct: 219 SAANDTGFVDLPQ-REKALMKAVATLGPISVAIDAGHQSFQFYKSGIYFDPDCSSKDLDH 277
Query: 445 GVLVVGY---GTEDGSNYWLVKNSWGTVWGIDGYIKMSKDANNQCGIATMASYPLV 603
GVLVVGY GT+ + +W+VKNSWG WG +GY+KM+KD NN CGIAT ASYP V
Sbjct: 278 GVLVVGYGFEGTDSNNKFWIVKNSWGPEWGWNGYVKMAKDQNNHCGIATAASYPTV 333
Score = 61.2 bits (147), Expect = 2e-09
Identities = 27/34 (79%), Positives = 29/34 (85%)
Frame = +3
Query: 3 KNQEQCGSCWSFSATGSLEGQHFRKTGNLTSFSE 104
KNQ QCGSCW+FSATG+LEGQ FRKTG L S SE
Sbjct: 130 KNQGQCGSCWAFSATGALEGQMFRKTGKLVSLSE 163
>sp|P25975|CATL_BOVIN Cathepsin L precursor [Contains: Cathepsin L heavy chain; Cathepsin
L light chain]
Length = 334
Score = 180 bits (456), Expect = 3e-45
Identities = 95/177 (53%), Positives = 117/177 (66%), Gaps = 6/177 (3%)
Frame = +1
Query: 91 LAFQKQQLVDXXXXXXXXXXXXXLMDNAFEYI-EKFGIESEDAYPYTAED-GTCLYDKSK 264
++ +Q LVD LMDNAF+YI + G++SE++YPY A D +C Y
Sbjct: 159 VSLSEQNLVDCSRAQGNQGCNGGLMDNAFQYIKDNGGLDSEESYPYLATDTNSCNYKPEC 218
Query: 265 VVGSCTGYVDIPGGSETSLATAAATVGPISVAIDASNYSFQLYKSGIYNEPDCSSTQLDH 444
+ TG+VDIP E +L A ATVGPISVAIDA + SFQ YKSGIY +PDCS LDH
Sbjct: 219 SAANDTGFVDIPQ-REKALMKAVATVGPISVAIDAGHTSFQFYKSGIYYDPDCSCKDLDH 277
Query: 445 GVLVVGYGTE----DGSNYWLVKNSWGTVWGIDGYIKMSKDANNQCGIATMASYPLV 603
GVLVVGYG E + + +W+VKNSWG WG +GY+KM+KD NN CGIAT ASYP V
Sbjct: 278 GVLVVGYGFEGTDSNNNKFWIVKNSWGPEWGWNGYVKMAKDQNNHCGIATAASYPTV 334
Score = 61.2 bits (147), Expect = 2e-09
Identities = 27/34 (79%), Positives = 29/34 (85%)
Frame = +3
Query: 3 KNQEQCGSCWSFSATGSLEGQHFRKTGNLTSFSE 104
KNQ QCGSCW+FSATG+LEGQ FRKTG L S SE
Sbjct: 130 KNQGQCGSCWAFSATGALEGQMFRKTGKLVSLSE 163
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 73,229,469
Number of Sequences: 369166
Number of extensions: 1496441
Number of successful extensions: 5027
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 4408
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 4721
length of database: 68,354,980
effective HSP length: 107
effective length of database: 48,588,335
effective search space used: 5733423530
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)