Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_027_H01
(642 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P02566|MYO4_CAEEL Myosin-4 (Myosin heavy chain B) (MHC B... 35 0.21
sp|P37709|TRHY_RABIT Trichohyalin 34 0.28
sp|P62290|ASPM_HYLLA Abnormal spindle-like microcephaly-ass... 32 1.1
sp|P62294|ASPM_PONPY Abnormal spindle-like microcephaly-ass... 32 1.1
sp|P62289|ASPM_GORGO Abnormal spindle-like microcephaly-ass... 32 1.4
sp|Q8IZT6|ASPM_HUMAN Abnormal spindle-like microcephaly-ass... 32 1.4
sp|P62293|ASPM_PANTR Abnormal spindle-like microcephaly-ass... 32 1.4
sp|Q15149|PLEC1_HUMAN Plectin 1 (PLTN) (PCN) (Hemidesmosoma... 32 1.8
sp|Q8CJ27|ASPM_MOUSE Abnormal spindle-like microcephaly-ass... 31 2.4
sp|Q6BSE2|ORC1_DEBHA Origin recognition complex subunit 1 31 2.4
>sp|P02566|MYO4_CAEEL Myosin-4 (Myosin heavy chain B) (MHC B) (Uncoordinated protein 54)
Length = 1966
Score = 34.7 bits (78), Expect = 0.21
Identities = 40/176 (22%), Positives = 74/176 (42%), Gaps = 9/176 (5%)
Frame = +2
Query: 71 DEAIRMVQIHERARQGRLRAKLMQEIRLQEDK---ERNAHTKSAQTMDFNEAALKIQRMW 241
DEAI + E+ Q + KLM++++ +EDK + K QT+D E +L+ ++
Sbjct: 998 DEAIAKLN-KEKKHQEEINRKLMEDLQSEEDKGNHQNKVKAKLEQTLDDLEDSLEREKRA 1056
Query: 242 RGILARRFVK-----KIKEEEFIWLGMTTPSV-SNASFKSAQLQRTLKIESDRRIKQAMF 403
R L ++ K KI +E G + +N K ++L D + +
Sbjct: 1057 RADLDKQKRKVEGELKIAQENIDESGRQRHDLENNLKKKESELHSVSSRLEDEQALVSKL 1116
Query: 404 EQEYNQALVTIKDKIRETEGPDMNESMKDQIRQWFLESRDILGKFPDFPDEEEGGS 571
+++ I + E E + S D+ + + LG+ D E+GG+
Sbjct: 1117 QRQIKDGQSRISELEEELENERQSRSKADRAKSDLQRELEELGEKLD----EQGGA 1168
>sp|P37709|TRHY_RABIT Trichohyalin
Length = 1407
Score = 34.3 bits (77), Expect = 0.28
Identities = 31/138 (22%), Positives = 59/138 (42%), Gaps = 5/138 (3%)
Frame = +2
Query: 95 IHERARQGRLRAKLMQEIRLQEDKERNAHTKSAQTMDFNEAALKIQRMWR-----GILAR 259
I E + R + +L +E+R +E + R + + + E L QR WR R
Sbjct: 201 IEEEQLRRREQQELKRELREEEQQRRERREQHERALQEEEEQLLRQRRWREEpreQQQLR 260
Query: 260 RFVKKIKEEEFIWLGMTTPSVSNASFKSAQLQRTLKIESDRRIKQAMFEQEYNQALVTIK 439
R +++I+E E + + QL+R ++E + R EQ+ + L I+
Sbjct: 261 RELEEIRERE--------QRLEQEERREQQLRREQRLEQEER-----REQQLRRELEEIR 307
Query: 440 DKIRETEGPDMNESMKDQ 493
++ + E + E +Q
Sbjct: 308 EREQRLEQEERREQRLEQ 325
>sp|P62290|ASPM_HYLLA Abnormal spindle-like microcephaly-associated protein homolog
Length = 3477
Score = 32.3 bits (72), Expect = 1.1
Identities = 23/84 (27%), Positives = 41/84 (48%), Gaps = 15/84 (17%)
Frame = +2
Query: 83 RMVQIHERARQGRLRAKLMQEIRLQEDKERNAHTKSA----QTMDFN-----------EA 217
R++ + + R RL ++ +L+ D +R+ T A Q+ N A
Sbjct: 1259 RLLDLRKEIRAARLIQTTWRKYKLKTDLKRHQETDKAARIIQSAVINFLAKQRLRKRVNA 1318
Query: 218 ALKIQRMWRGILARRFVKKIKEEE 289
AL IQ+ WR +LA+R + +K+E+
Sbjct: 1319 ALVIQKYWRRVLAQRKLLMLKKEK 1342
>sp|P62294|ASPM_PONPY Abnormal spindle-like microcephaly-associated protein homolog
Length = 3471
Score = 32.3 bits (72), Expect = 1.1
Identities = 20/84 (23%), Positives = 43/84 (51%), Gaps = 15/84 (17%)
Frame = +2
Query: 83 RMVQIHERARQGRL------RAKLMQEIRLQEDKERNAHTKSAQTMDFN---------EA 217
R++ + + R RL + KL +++ +++E+ A + ++F A
Sbjct: 1253 RLLDLRKEIRAARLIQTTWRKYKLKTDLKRHQEREKAARIIQSAVINFLAKQRLRKRVNA 1312
Query: 218 ALKIQRMWRGILARRFVKKIKEEE 289
AL +Q+ WR +LA+R + +K+E+
Sbjct: 1313 ALVVQKYWRRVLAQRKLLMLKKEK 1336
>sp|P62289|ASPM_GORGO Abnormal spindle-like microcephaly-associated protein homolog
Length = 3476
Score = 32.0 bits (71), Expect = 1.4
Identities = 21/84 (25%), Positives = 42/84 (50%), Gaps = 15/84 (17%)
Frame = +2
Query: 83 RMVQIHERARQGRL------RAKLMQEIRLQEDKERNAHTKSAQTMDFN---------EA 217
R++ + + R RL + KL +++ +++E+ A ++F A
Sbjct: 1258 RLLDLRKEIRAARLIQTTWRKYKLKTDLKRHQEREKAARIIQLAVINFLAKQRLRKRVNA 1317
Query: 218 ALKIQRMWRGILARRFVKKIKEEE 289
AL IQ+ WR +LA+R + +K+E+
Sbjct: 1318 ALVIQKYWRRVLAQRKLLMLKKEK 1341
>sp|Q8IZT6|ASPM_HUMAN Abnormal spindle-like microcephaly-associated protein (Abnormal
spindle protein homolog) (Asp homolog)
Length = 3477
Score = 32.0 bits (71), Expect = 1.4
Identities = 21/84 (25%), Positives = 42/84 (50%), Gaps = 15/84 (17%)
Frame = +2
Query: 83 RMVQIHERARQGRL------RAKLMQEIRLQEDKERNAHTKSAQTMDFN---------EA 217
R++ + + R RL + KL +++ +++E+ A ++F A
Sbjct: 1259 RLLDLRKEIRAARLIQTTWRKYKLKTDLKRHQEREKAARIIQLAVINFLAKQRLRKRVNA 1318
Query: 218 ALKIQRMWRGILARRFVKKIKEEE 289
AL IQ+ WR +LA+R + +K+E+
Sbjct: 1319 ALVIQKYWRRVLAQRKLLMLKKEK 1342
>sp|P62293|ASPM_PANTR Abnormal spindle-like microcephaly-associated protein homolog
Length = 3477
Score = 32.0 bits (71), Expect = 1.4
Identities = 21/84 (25%), Positives = 42/84 (50%), Gaps = 15/84 (17%)
Frame = +2
Query: 83 RMVQIHERARQGRL------RAKLMQEIRLQEDKERNAHTKSAQTMDFN---------EA 217
R++ + + R RL + KL +++ +++E+ A ++F A
Sbjct: 1259 RLLDLRKEIRAARLIQTTWRKYKLKTDLKRHQEREKAARIIQLAVINFLAKQRLRKRVNA 1318
Query: 218 ALKIQRMWRGILARRFVKKIKEEE 289
AL IQ+ WR +LA+R + +K+E+
Sbjct: 1319 ALVIQKYWRRVLAQRKLLMLKKEK 1342
>sp|Q15149|PLEC1_HUMAN Plectin 1 (PLTN) (PCN) (Hemidesmosomal protein 1) (HD1)
Length = 4684
Score = 31.6 bits (70), Expect = 1.8
Identities = 46/211 (21%), Positives = 90/211 (42%), Gaps = 36/211 (17%)
Frame = +2
Query: 68 LDEAIRMVQIHERARQGRLRAKLMQEIRLQEDKERNAHTKSAQTMDFNEA---------- 217
+ EA R+ E +Q + A+ Q RLQEDKE+ A + +T F
Sbjct: 2456 VQEATRLKAEAELLQQQKELAQ-EQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLE 2514
Query: 218 --------ALKIQRMWRGIL-----ARRFVKKIKEEEFIWLGMTTPSVSNASFKSAQLQR 358
L++ M R A+RF K+ +E +G A+ + L +
Sbjct: 2515 MSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEE-----IGEKLHRTELATQEKVTLVQ 2569
Query: 359 TLKIESDR------RIKQAMFEQEYNQALVTIKDKIRETEGPDMNESMKDQ-------IR 499
TL+I+ + R+++A+ E E + + + K+ + + +M ++Q ++
Sbjct: 2570 TLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQ 2629
Query: 500 QWFLESRDILGKFPDFPDEEEGGSLIIFKEK 592
Q FL +D L + F ++E+ +F+++
Sbjct: 2630 QSFLSEKDSLLQRERFIEQEKAKLEQLFQDE 2660
>sp|Q8CJ27|ASPM_MOUSE Abnormal spindle-like microcephaly-associated protein homolog
(Calmodulin-binding protein 1) (Spindle and hydroxyurea
checkpoint abnormal protein) (Calmodulin-binding protein
Sha1)
Length = 3122
Score = 31.2 bits (69), Expect = 2.4
Identities = 19/84 (22%), Positives = 43/84 (51%), Gaps = 15/84 (17%)
Frame = +2
Query: 83 RMVQIHERARQGRL------RAKLMQEIRLQEDKERNAHTKSAQTMDFNE---------A 217
R++ + + R RL + KL ++++ +++++ A + ++F A
Sbjct: 1227 RLLDLRKEIRAARLIQTTWRKYKLKRDLKHHQERDKAARVIQSVVLNFLSRRRLQKNVSA 1286
Query: 218 ALKIQRMWRGILARRFVKKIKEEE 289
AL IQ+ WR + A+R ++ +K E+
Sbjct: 1287 ALVIQKCWRRVSAQRKLRMLKNEK 1310
>sp|Q6BSE2|ORC1_DEBHA Origin recognition complex subunit 1
Length = 810
Score = 31.2 bits (69), Expect = 2.4
Identities = 31/90 (34%), Positives = 43/90 (47%), Gaps = 5/90 (5%)
Frame = +2
Query: 308 TTPSVSNASFKSAQLQR-TLKIESDR-RIKQAMF---EQEYNQALVTIKDKIRETEGPDM 472
TTPS + KS Q+ +LK E D IK+ F +Q+ N V I +I+
Sbjct: 31 TTPSRRSRRGKSTSSQKISLKREEDELEIKEGDFLLVQQDNNSPEVAIVKEIKFG----- 85
Query: 473 NESMKDQIRQWFLESRDILGKFPDFPDEEE 562
N++ D I WF+ RDI + D P EE
Sbjct: 86 NDNFLDIIVSWFIRMRDI--EEADLPKVEE 113
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 59,304,971
Number of Sequences: 369166
Number of extensions: 1026796
Number of successful extensions: 3103
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 2910
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 3094
length of database: 68,354,980
effective HSP length: 106
effective length of database: 48,773,070
effective search space used: 5218718490
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)