Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_027_F06
(528 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q26636|CATL_SARPE Cathepsin L precursor [Contains: Cathe... 196 4e-50
sp|Q95029|CATL_DROME Cathepsin L precursor (Cysteine protei... 196 4e-50
sp|Q10991|CATL_SHEEP Cathepsin L [Contains: Cathepsin L hea... 195 6e-50
sp|P25782|CYSP2_HOMAM Digestive cysteine proteinase 2 precu... 192 5e-49
sp|P07711|CATL_HUMAN Cathepsin L precursor (Major excreted ... 187 2e-47
sp|P25975|CATL_BOVIN Cathepsin L precursor [Contains: Cathe... 186 2e-47
sp|O60911|CATL2_HUMAN Cathepsin L2 precursor (Cathepsin V) ... 185 5e-47
sp|Q9GL24|CATL_CANFA Cathepsin L precursor [Contains: Cathe... 185 5e-47
sp|P25784|CYSP3_HOMAM Digestive cysteine proteinase 3 precu... 184 1e-46
sp|P07154|CATL_RAT Cathepsin L precursor (Major excreted pr... 182 6e-46
>sp|Q26636|CATL_SARPE Cathepsin L precursor [Contains: Cathepsin L heavy chain; Cathepsin
L light chain]
Length = 339
Score = 196 bits (497), Expect = 4e-50
Identities = 94/155 (60%), Positives = 109/155 (70%), Gaps = 2/155 (1%)
Frame = +1
Query: 1 GCGGGLMDNAFRYIKDQG-IESEGDYPYTATDGTCKRNPSKIVTKCTGFTDIQSQNETDL 177
GC GGLMDNAFRYIKD G I++E YPY D +C N + I TGF DI +E +
Sbjct: 185 GCNGGLMDNAFRYIKDNGGIDTEKSYPYEGIDDSCHFNKATIGATDTGFVDIPEGDEEKM 244
Query: 178 ANAVATVGPVSVAIDAGHASFQLYKSGIYNEESCSTTQLDHGVLAVGYGT-QIGKKYWIV 354
AVAT+GPVSVAIDA H SFQLY G+YNE C LDHGVL VGYGT + G YW+V
Sbjct: 245 KKAVATMGPVSVAIDASHESFQLYSEGVYNEPECDEQNLDHGVLVVGYGTDESGMDYWLV 304
Query: 355 KNSWDVTWGESGYIKMSKDKKNQCGIATMASYPLV 459
KNSW TWGE GYIKM++++ NQCGIAT +SYP V
Sbjct: 305 KNSWGTTWGEQGYIKMARNQNNQCGIATASSYPTV 339
>sp|Q95029|CATL_DROME Cathepsin L precursor (Cysteine proteinase 1) [Contains: Cathepsin
L heavy chain; Cathepsin L light chain]
Length = 341
Score = 196 bits (497), Expect = 4e-50
Identities = 93/155 (60%), Positives = 111/155 (71%), Gaps = 2/155 (1%)
Frame = +1
Query: 1 GCGGGLMDNAFRYIKDQG-IESEGDYPYTATDGTCKRNPSKIVTKCTGFTDIQSQNETDL 177
GC GGLMDNAFRYIKD G I++E YPY A D +C N + GFTDI +E +
Sbjct: 187 GCNGGLMDNAFRYIKDNGGIDTEKSYPYEAIDDSCHFNKGTVGATDRGFTDIPQGDEKKM 246
Query: 178 ANAVATVGPVSVAIDAGHASFQLYKSGIYNEESCSTTQLDHGVLAVGYGT-QIGKKYWIV 354
A AVATVGPVSVAIDA H SFQ Y G+YNE C LDHGVL VG+GT + G+ YW+V
Sbjct: 247 AEAVATVGPVSVAIDASHESFQFYSEGVYNEPQCDAQNLDHGVLVVGFGTDESGEDYWLV 306
Query: 355 KNSWDVTWGESGYIKMSKDKKNQCGIATMASYPLV 459
KNSW TWG+ G+IKM ++K+NQCGIA+ +SYPLV
Sbjct: 307 KNSWGTTWGDKGFIKMLRNKENQCGIASASSYPLV 341
>sp|Q10991|CATL_SHEEP Cathepsin L [Contains: Cathepsin L heavy chain; Cathepsin L light
chain]
Length = 217
Score = 195 bits (495), Expect = 6e-50
Identities = 96/155 (61%), Positives = 110/155 (70%), Gaps = 2/155 (1%)
Frame = +1
Query: 1 GCGGGLMDNAFRYIKDQG-IESEGDYPYTATDGTCKRNPSKIVTKCTGFTDIQSQNETDL 177
GC GGLMDNAF+YIK+ G ++SE YPY ATD +C P K TGF DI Q E L
Sbjct: 64 GCNGGLMDNAFQYIKENGGLDSEESYPYEATDTSCNYKPEYSAAKDTGFVDIP-QREKAL 122
Query: 178 ANAVATVGPVSVAIDAGHASFQLYKSGIYNEESCSTTQLDHGVLAVGYGTQ-IGKKYWIV 354
AVATVGP+SVAIDAGH+SFQ YKSGIY + CS+ LDHGVL VGYG + K+WIV
Sbjct: 123 MKAVATVGPISVAIDAGHSSFQFYKSGIYYDPDCSSKDLDHGVLVVGYGFEGTNNKFWIV 182
Query: 355 KNSWDVTWGESGYIKMSKDKKNQCGIATMASYPLV 459
KNSW WG GY+KM+KD+ N CGIAT ASYP V
Sbjct: 183 KNSWGPEWGNKGYVKMAKDQNNHCGIATAASYPTV 217
>sp|P25782|CYSP2_HOMAM Digestive cysteine proteinase 2 precursor
Length = 323
Score = 192 bits (487), Expect = 5e-49
Identities = 86/154 (55%), Positives = 116/154 (75%), Gaps = 1/154 (0%)
Frame = +1
Query: 1 GCGGGLMDNAFRYIK-DQGIESEGDYPYTATDGTCKRNPSKIVTKCTGFTDIQSQNETDL 177
GC GG M++AF YIK + GI++E YPY A DG+C+ + + + C+G T+I S +ET L
Sbjct: 170 GCNGGWMNDAFDYIKANNGIDTEAAYPYEARDGSCRFDSNSVAATCSGHTNIASGSETGL 229
Query: 178 ANAVATVGPVSVAIDAGHASFQLYKSGIYNEESCSTTQLDHGVLAVGYGTQIGKKYWIVK 357
AV +GP+SV IDA H+SFQ Y SG+Y E SCS + LDH VLAVGYG++ G+ +W+VK
Sbjct: 230 QQAVRDIGPISVTIDAAHSSFQFYSSGVYYEPSCSPSYLDHAVLAVGYGSEGGQDFWLVK 289
Query: 358 NSWDVTWGESGYIKMSKDKKNQCGIATMASYPLV 459
NSW +WG++GYIKMS+++ N CGIAT+ASYPLV
Sbjct: 290 NSWATSWGDAGYIKMSRNRNNNCGIATVASYPLV 323
>sp|P07711|CATL_HUMAN Cathepsin L precursor (Major excreted protein) (MEP) [Contains:
Cathepsin L heavy chain; Cathepsin L light chain]
Length = 333
Score = 187 bits (474), Expect = 2e-47
Identities = 92/158 (58%), Positives = 109/158 (68%), Gaps = 5/158 (3%)
Frame = +1
Query: 1 GCGGGLMDNAFRYIKDQG-IESEGDYPYTATDGTCKRNPSKIVTKCTGFTDIQSQNETDL 177
GC GGLMD AF+Y++D G ++SE YPY AT+ +CK NP V TGF DI Q E L
Sbjct: 177 GCNGGLMDYAFQYVQDNGGLDSEESYPYEATEESCKYNPKYSVANDTGFVDIPKQ-EKAL 235
Query: 178 ANAVATVGPVSVAIDAGHASFQLYKSGIYNEESCSTTQLDHGVLAVGYGTQI----GKKY 345
AVATVGP+SVAIDAGH SF YK GIY E CS+ +DHGVL VGYG + KY
Sbjct: 236 MKAVATVGPISVAIDAGHESFLFYKEGIYFEPDCSSEDMDHGVLVVGYGFESTESDNNKY 295
Query: 346 WIVKNSWDVTWGESGYIKMSKDKKNQCGIATMASYPLV 459
W+VKNSW WG GY+KM+KD++N CGIA+ ASYP V
Sbjct: 296 WLVKNSWGEEWGMGGYVKMAKDRRNHCGIASAASYPTV 333
>sp|P25975|CATL_BOVIN Cathepsin L precursor [Contains: Cathepsin L heavy chain; Cathepsin
L light chain]
Length = 334
Score = 186 bits (473), Expect = 2e-47
Identities = 96/159 (60%), Positives = 108/159 (67%), Gaps = 6/159 (3%)
Frame = +1
Query: 1 GCGGGLMDNAFRYIKDQG-IESEGDYPYTATD-GTCKRNPSKIVTKCTGFTDIQSQNETD 174
GC GGLMDNAF+YIKD G ++SE YPY ATD +C P TGF DI Q E
Sbjct: 177 GCNGGLMDNAFQYIKDNGGLDSEESYPYLATDTNSCNYKPECSAANDTGFVDIP-QREKA 235
Query: 175 LANAVATVGPVSVAIDAGHASFQLYKSGIYNEESCSTTQLDHGVLAVGYGTQ----IGKK 342
L AVATVGP+SVAIDAGH SFQ YKSGIY + CS LDHGVL VGYG + K
Sbjct: 236 LMKAVATVGPISVAIDAGHTSFQFYKSGIYYDPDCSCKDLDHGVLVVGYGFEGTDSNNNK 295
Query: 343 YWIVKNSWDVTWGESGYIKMSKDKKNQCGIATMASYPLV 459
+WIVKNSW WG +GY+KM+KD+ N CGIAT ASYP V
Sbjct: 296 FWIVKNSWGPEWGWNGYVKMAKDQNNHCGIATAASYPTV 334
>sp|O60911|CATL2_HUMAN Cathepsin L2 precursor (Cathepsin V) (Cathepsin U)
Length = 334
Score = 185 bits (470), Expect = 5e-47
Identities = 90/158 (56%), Positives = 105/158 (66%), Gaps = 5/158 (3%)
Frame = +1
Query: 1 GCGGGLMDNAFRYIKDQG-IESEGDYPYTATDGTCKRNPSKIVTKCTGFTDIQSQNETDL 177
GC GG M AF+Y+K+ G ++SE YPY A D CK P V TGFT + E L
Sbjct: 177 GCNGGFMARAFQYVKENGGLDSEESYPYVAVDEICKYRPENSVANDTGFTVVAPGKEKAL 236
Query: 178 ANAVATVGPVSVAIDAGHASFQLYKSGIYNEESCSTTQLDHGVLAVGYG----TQIGKKY 345
AVATVGP+SVA+DAGH+SFQ YKSGIY E CS+ LDHGVL VGYG KY
Sbjct: 237 MKAVATVGPISVAMDAGHSSFQFYKSGIYFEPDCSSKNLDHGVLVVGYGFEGANSNNSKY 296
Query: 346 WIVKNSWDVTWGESGYIKMSKDKKNQCGIATMASYPLV 459
W+VKNSW WG +GY+K++KDK N CGIAT ASYP V
Sbjct: 297 WLVKNSWGPEWGSNGYVKIAKDKNNHCGIATAASYPNV 334
>sp|Q9GL24|CATL_CANFA Cathepsin L precursor [Contains: Cathepsin L heavy chain; Cathepsin
L light chain]
Length = 333
Score = 185 bits (470), Expect = 5e-47
Identities = 94/158 (59%), Positives = 107/158 (67%), Gaps = 5/158 (3%)
Frame = +1
Query: 1 GCGGGLMDNAFRYIKDQG-IESEGDYPYTATDG-TCKRNPSKIVTKCTGFTDIQSQNETD 174
GC GGLMDNAFRY+KD G ++SE YPY D TC P TGF D+ Q E
Sbjct: 177 GCNGGLMDNAFRYVKDNGGLDSEESYPYLGRDTETCNYKPECSAANDTGFVDLP-QREKA 235
Query: 175 LANAVATVGPVSVAIDAGHASFQLYKSGIYNEESCSTTQLDHGVLAVGY---GTQIGKKY 345
L AVAT+GP+SVAIDAGH SFQ YKSGIY + CS+ LDHGVL VGY GT K+
Sbjct: 236 LMKAVATLGPISVAIDAGHQSFQFYKSGIYFDPDCSSKDLDHGVLVVGYGFEGTDSNNKF 295
Query: 346 WIVKNSWDVTWGESGYIKMSKDKKNQCGIATMASYPLV 459
WIVKNSW WG +GY+KM+KD+ N CGIAT ASYP V
Sbjct: 296 WIVKNSWGPEWGWNGYVKMAKDQNNHCGIATAASYPTV 333
>sp|P25784|CYSP3_HOMAM Digestive cysteine proteinase 3 precursor
Length = 321
Score = 184 bits (467), Expect = 1e-46
Identities = 88/154 (57%), Positives = 111/154 (72%), Gaps = 1/154 (0%)
Frame = +1
Query: 1 GCGGGLMDNAFRYIKDQG-IESEGDYPYTATDGTCKRNPSKIVTKCTGFTDIQSQNETDL 177
GCGGG M +AF YIKD G I++E YPY A D +C+ + + I CTG ++Q E L
Sbjct: 169 GCGGGWMTSAFDYIKDNGGIDTESSYPYEAEDRSCRFDANSIGAICTGSVEVQHTEEA-L 227
Query: 178 ANAVATVGPVSVAIDAGHASFQLYKSGIYNEESCSTTQLDHGVLAVGYGTQIGKKYWIVK 357
AV+ VGP+SVAIDA H SFQ Y SG+Y E++CS T LDHGVLAVGYGT+ K YW+VK
Sbjct: 228 QEAVSGVGPISVAIDASHFSFQFYSSGVYYEQNCSPTFLDHGVLAVGYGTESTKDYWLVK 287
Query: 358 NSWDVTWGESGYIKMSKDKKNQCGIATMASYPLV 459
NSW +WG++GYIKMS+++ N CGIA+ SYP V
Sbjct: 288 NSWGSSWGDAGYIKMSRNRDNNCGIASEPSYPTV 321
>sp|P07154|CATL_RAT Cathepsin L precursor (Major excreted protein) (MEP) (Cyclic
protein 2) (CP-2) [Contains: Cathepsin L heavy chain;
Cathepsin L light chain]
Length = 334
Score = 182 bits (461), Expect = 6e-46
Identities = 93/158 (58%), Positives = 108/158 (68%), Gaps = 5/158 (3%)
Frame = +1
Query: 1 GCGGGLMDNAFRYIKDQG-IESEGDYPYTATDGTCKRNPSKIVTKCTGFTDIQSQNETDL 177
GC GGLMD AF+YIK+ G ++SE YPY A DG+CK V TGF DI Q E L
Sbjct: 177 GCNGGLMDFAFQYIKENGGLDSEESYPYEAKDGSCKYRAEYAVANDTGFVDIPQQ-EKAL 235
Query: 178 ANAVATVGPVSVAIDAGHASFQLYKSGIYNEESCSTTQLDHGVLAVGY---GTQIGK-KY 345
AVATVGP+SVA+DA H S Q Y SGIY E +CS+ LDHGVL VGY GT K KY
Sbjct: 236 MKAVATVGPISVAMDASHPSLQFYSSGIYYEPNCSSKDLDHGVLVVGYGYEGTDSNKDKY 295
Query: 346 WIVKNSWDVTWGESGYIKMSKDKKNQCGIATMASYPLV 459
W+VKNSW WG GYIK++KD+ N CG+AT ASYP+V
Sbjct: 296 WLVKNSWGKEWGMDGYIKIAKDRNNHCGLATAASYPIV 333
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 63,499,205
Number of Sequences: 369166
Number of extensions: 1266468
Number of successful extensions: 3987
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 3515
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 3598
length of database: 68,354,980
effective HSP length: 103
effective length of database: 49,327,275
effective search space used: 3551563800
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)