Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_027_E22
(893 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|O60341|LSD1_HUMAN Lysine-specific histone demethylase 1 ... 118 3e-26
sp|Q6ZQ88|LSD1_MOUSE Lysine-specific histone demethylase 1 ... 118 3e-26
sp|Q9NWM0|SMOX_HUMAN Spermine oxidase (Polyamine oxidase 1)... 73 9e-13
sp|Q99K82|SMOX_MOUSE Spermine oxidase (Polyamine oxidase 1)... 72 3e-12
sp|Q6QHF9|PAOX_HUMAN Peroxisomal N1-acetyl-spermine/spermid... 72 3e-12
sp|Q9XWP6|SPR5_CAEEL Suppressor of presenilin 5 (P110b homo... 71 4e-12
sp|Q8C0L6|PAOX_MOUSE Peroxisomal N1-acetyl-spermine/spermid... 70 1e-11
sp||Q865R1_3 [Segment 3 of 3] Peroxisomal N1-acetyl-spermin... 70 1e-11
sp|Q21988|AMX1_CAEEL Amine oxidase family member 1 67 7e-11
sp|O64411|PAO_MAIZE Polyamine oxidase precursor 63 1e-09
>sp|O60341|LSD1_HUMAN Lysine-specific histone demethylase 1 (Amine oxidase flavin
containing domain protein 2) (AOF2 protein) (BRAF35-HDAC
complex protein BHC110)
Length = 852
Score = 118 bits (295), Expect = 3e-26
Identities = 84/259 (32%), Positives = 117/259 (45%)
Frame = +3
Query: 6 FKSDVVVCTLPLGVLKESINNPVGTNSPQFSPPLPEWKVKSINALGFGMFDKVVMCFKER 185
+K D V+CTLPLGVLK+ + QF PPLPEWK ++ +GFG +KVV+CF
Sbjct: 616 YKCDAVLCTLPLGVLKQQ------PPAVQFVPPLPEWKTSAVQRMGFGNLNKVVLCFDRV 669
Query: 186 FWGSNNMKVFAQLKSKREQRGEFMQFYAFSRKDASRXXXXXXXXXXXXXXXXKQXXXXXX 365
FW ++ +F + S RGE F+ +
Sbjct: 670 FW-DPSVNLFGHVGSTTASRGELFLFWNLYK------------------------APILL 704
Query: 366 XXXCGEAATAYALEKDLTDAEMGKRALQSLRDIFLKRKITVPEPSLIHVYRWTKDLHARG 545
GEAA + ++++D + R L L+ IF VP+P V RW D ARG
Sbjct: 705 ALVAGEAA---GIMENISDDVIVGRCLAILKGIF--GSSAVPQPKETVVSRWRADPWARG 759
Query: 546 VFSYIPEGASLTDVENAAAPLPVQEQDTNQRQRRSGGPVQLVVPRLFFAGEHTHSAGIGT 725
+SY+ G+S D + A P+ Q +PRLFFAGEHT T
Sbjct: 760 SYSYVAAGSSGNDYDLMAQPITPGPSIPGAPQ---------PIPRLFFAGEHTIRNYPAT 810
Query: 726 IQGAMMSGLRAASDICKYY 782
+ GA++SGLR A I +
Sbjct: 811 VHGALLSGLREAGRIADQF 829
>sp|Q6ZQ88|LSD1_MOUSE Lysine-specific histone demethylase 1 (Amine oxidase flavin
containing domain protein 2) (AOF2 protein) (BRAF35-HDAC
complex protein BHC110)
Length = 853
Score = 118 bits (295), Expect = 3e-26
Identities = 84/259 (32%), Positives = 117/259 (45%)
Frame = +3
Query: 6 FKSDVVVCTLPLGVLKESINNPVGTNSPQFSPPLPEWKVKSINALGFGMFDKVVMCFKER 185
+K D V+CTLPLGVLK+ + QF PPLPEWK ++ +GFG +KVV+CF
Sbjct: 617 YKCDAVLCTLPLGVLKQQ------PPAVQFVPPLPEWKTSAVQRMGFGNLNKVVLCFDRV 670
Query: 186 FWGSNNMKVFAQLKSKREQRGEFMQFYAFSRKDASRXXXXXXXXXXXXXXXXKQXXXXXX 365
FW ++ +F + S RGE F+ +
Sbjct: 671 FW-DPSVNLFGHVGSTTASRGELFLFWNLYK------------------------APILL 705
Query: 366 XXXCGEAATAYALEKDLTDAEMGKRALQSLRDIFLKRKITVPEPSLIHVYRWTKDLHARG 545
GEAA + ++++D + R L L+ IF VP+P V RW D ARG
Sbjct: 706 ALVAGEAA---GIMENISDDVIVGRCLAILKGIF--GSSAVPQPKETVVSRWRADPWARG 760
Query: 546 VFSYIPEGASLTDVENAAAPLPVQEQDTNQRQRRSGGPVQLVVPRLFFAGEHTHSAGIGT 725
+SY+ G+S D + A P+ Q +PRLFFAGEHT T
Sbjct: 761 SYSYVAAGSSGNDYDLMAQPITPGPSIPGAPQ---------PIPRLFFAGEHTIRNYPAT 811
Query: 726 IQGAMMSGLRAASDICKYY 782
+ GA++SGLR A I +
Sbjct: 812 VHGALLSGLREAGRIADQF 830
>sp|Q9NWM0|SMOX_HUMAN Spermine oxidase (Polyamine oxidase 1) (PAO-1) (PAOh1)
Length = 555
Score = 73.2 bits (178), Expect = 9e-13
Identities = 69/257 (26%), Positives = 101/257 (39%)
Frame = +3
Query: 12 SDVVVCTLPLGVLKESINNPVGTNSPQFSPPLPEWKVKSINALGFGMFDKVVMCFKERFW 191
+D V+ T+ LGVLK + F P LP KV +I+ LG G DK+ + F+E FW
Sbjct: 325 ADHVIVTVSLGVLKRQYTS-------FFRPGLPTEKVAAIHRLGIGTTDKIFLEFEEPFW 377
Query: 192 GSNNMKVFAQLKSKREQRGEFMQFYAFSRKDASRXXXXXXXXXXXXXXXXKQXXXXXXXX 371
G + + + E + RK ++
Sbjct: 378 GPECNSLQFVWEDEAESHTLTYPPELWYRKICG----------FDVLYPPERYGHVLSGW 427
Query: 372 XCGEAATAYALEKDLTDAEMGKRALQSLRDIFLKRKITVPEPSLIHVYRWTKDLHARGVF 551
CGE A D AE+ L+ +P+P I W + + RG +
Sbjct: 428 ICGEEALVMEKCDDEAVAEICTEMLRQFTG-----NPNIPKPRRILRSAWGSNPYFRGSY 482
Query: 552 SYIPEGASLTDVENAAAPLPVQEQDTNQRQRRSGGPVQLVVPRLFFAGEHTHSAGIGTIQ 731
SY G+S DVE A PLP E P+Q++ F+GE TH T
Sbjct: 483 SYTQVGSSGADVEKLAKPLPYTESSKT-------APMQVL-----FSGEATHRKYYSTTH 530
Query: 732 GAMMSGLRAASDICKYY 782
GA++SG R A+ + + Y
Sbjct: 531 GALLSGQREAARLIEMY 547
>sp|Q99K82|SMOX_MOUSE Spermine oxidase (Polyamine oxidase 1) (PAO-1) (PAOh1)
Length = 555
Score = 71.6 bits (174), Expect = 3e-12
Identities = 69/257 (26%), Positives = 101/257 (39%)
Frame = +3
Query: 12 SDVVVCTLPLGVLKESINNPVGTNSPQFSPPLPEWKVKSINALGFGMFDKVVMCFKERFW 191
+D V+ T+ LGVLK + F P LP KV +I+ LG G DK+ + F+E FW
Sbjct: 325 ADHVIVTVSLGVLKRQYTS-------FFRPCLPTEKVAAIHRLGIGTTDKIFLEFEEPFW 377
Query: 192 GSNNMKVFAQLKSKREQRGEFMQFYAFSRKDASRXXXXXXXXXXXXXXXXKQXXXXXXXX 371
G + + + E + RK ++
Sbjct: 378 GPECNSLQFVWEDEAESCTLTYPPELWYRKICG----------FDVLYPPERYGHVLSGW 427
Query: 372 XCGEAATAYALEKDLTDAEMGKRALQSLRDIFLKRKITVPEPSLIHVYRWTKDLHARGVF 551
CGE A D AE+ L+ +P+P I W + + RG +
Sbjct: 428 ICGEEALVMERCDDEAVAEICTEMLRQFTG-----NPNIPKPRRILRSAWGSNPYFRGSY 482
Query: 552 SYIPEGASLTDVENAAAPLPVQEQDTNQRQRRSGGPVQLVVPRLFFAGEHTHSAGIGTIQ 731
SY G+S DVE A PLP E P+Q++ F+GE TH T
Sbjct: 483 SYTQVGSSGADVEKLAKPLPYTESSKT-------APMQVL-----FSGEATHRKYYSTTH 530
Query: 732 GAMMSGLRAASDICKYY 782
GA++SG R A+ + + Y
Sbjct: 531 GALLSGQREAARLIEMY 547
>sp|Q6QHF9|PAOX_HUMAN Peroxisomal N1-acetyl-spermine/spermidine oxidase (Polyamine oxidase)
Length = 649
Score = 71.6 bits (174), Expect = 3e-12
Identities = 70/276 (25%), Positives = 112/276 (40%), Gaps = 6/276 (2%)
Frame = +3
Query: 6 FKSDVVVCTLPLGVLKESINNPVGTNSPQFSPPLPEWKVKSINALGFGMFDKVVMCFKER 185
F + V+ T+PLG L+E ++ F PPLP K ++I +GFG +K+ + F+E
Sbjct: 416 FPAHHVIVTVPLGFLREHLDT-------FFDPPLPAEKAEAIRKIGFGTNNKIFLEFEEP 468
Query: 186 FWGSNN--MKVFAQLKSKREQRGEFMQFYAFSRKDASRXXXXXXXXXXXXXXXXKQXXXX 359
FW + +++ + S E +Q F +
Sbjct: 469 FWEPDCQLIQLVWEDTSPLEDAAPELQDAWFRK----------------LIGFVVLPAFA 512
Query: 360 XXXXXCGEAATAYALEKDLTDAEMGKRALQSLRDIFLKRKIT----VPEPSLIHVYRWTK 527
CG A LE + + + L L + R++T +P P + RW
Sbjct: 513 SVHVLCGFIA---GLESEFMETLSDEEVLLCLTQVL--RRVTGNPRLPAPKSVLRSRWHS 567
Query: 528 DLHARGVFSYIPEGASLTDVENAAAPLPVQEQDTNQRQRRSGGPVQLVVPRLFFAGEHTH 707
+ RG +SY+ G++ D++ A PLP G QL ++ FAGE TH
Sbjct: 568 APYTRGSYSYVAVGSTGGDLDLLAQPLPAD-----------GAGAQL---QILFAGEATH 613
Query: 708 SAGIGTIQGAMMSGLRAASDICKYYFPQLPNILSRL 815
T GA++SG R A + + PQ+ RL
Sbjct: 614 RTFYSTTHGALLSGWREADRLLSLWAPQVQQPRPRL 649
>sp|Q9XWP6|SPR5_CAEEL Suppressor of presenilin 5 (P110b homolog)
Length = 770
Score = 71.2 bits (173), Expect = 4e-12
Identities = 70/255 (27%), Positives = 107/255 (41%), Gaps = 1/255 (0%)
Frame = +3
Query: 9 KSDVVVCTLPLGVLKESINNPVGTNSPQFSPPLPEWKVKSINALGFGMFDKVVMCFKERF 188
K+ VV TLP+GVLK++I +P F+P LP+ KV++I +G G +K ++ F F
Sbjct: 471 KAAFVVSTLPIGVLKKTII--ADERAPTFTPSLPDKKVEAIRNIGCGSVNKCILEFDRVF 528
Query: 189 WGSN-NMKVFAQLKSKREQRGEFMQFYAFSRKDASRXXXXXXXXXXXXXXXXKQXXXXXX 365
W +N F + + RG +S S+
Sbjct: 529 WTANGGRNQFVTVSPNIKTRG---SMNIWSSVPGSK---------------------VLC 564
Query: 366 XXXCGEAATAYALEKDLTDAEMGKRALQSLRDIFLKRKITVPEPSLIHVYRWTKDLHARG 545
GE A +L D + + A+ +L+ F P + H+ RW D A G
Sbjct: 565 TYIVGEEAML-----ELPDDVIIQNAMINLQKAFGNNCPRAPISA--HITRWHDDELAFG 617
Query: 546 VFSYIPEGASLTDVENAAAPLPVQEQDTNQRQRRSGGPVQLVVPRLFFAGEHTHSAGIGT 725
+++ T ++ PL + + R++FAGEHT S+ T
Sbjct: 618 SGAFMSLRTETTSFDDVMEPLKTSDG----------------MSRVYFAGEHTCSSYTST 661
Query: 726 IQGAMMSGLRAASDI 770
IQGA MSG RAA+DI
Sbjct: 662 IQGAWMSGARAAADI 676
>sp|Q8C0L6|PAOX_MOUSE Peroxisomal N1-acetyl-spermine/spermidine oxidase (Polyamine
oxidase)
Length = 504
Score = 69.7 bits (169), Expect = 1e-11
Identities = 71/269 (26%), Positives = 105/269 (39%), Gaps = 4/269 (1%)
Frame = +3
Query: 21 VVCTLPLGVLKESINNPVGTNSPQFSPPLPEWKVKSINALGFGMFDKVVMCFKERFWGSN 200
V+ T+PLG LKE F PPLP K ++I LGFG +K+ + F+E FW +
Sbjct: 276 VIVTVPLGFLKEH-------QDTFFEPPLPAKKAEAIKKLGFGTNNKIFLEFEEPFWEPD 328
Query: 201 NMKVFAQLKSKREQRGEFMQFYAFSRKDASRXXXXXXXXXXXXXXXXKQXXXXXXXXXCG 380
+ + +Q A S +D Q CG
Sbjct: 329 CQFIQVVWEDTSP-----LQDTALSLQDT---------WFKKLIGFLVQPSFESSHVLCG 374
Query: 381 EAATAYALEKDLTDAEMGKRALQSLRDIFLKRKIT----VPEPSLIHVYRWTKDLHARGV 548
A LE + + + L SL + R++T +P + +W + RG
Sbjct: 375 FIA---GLESEFMETLSDEEVLLSLTQVL--RRVTGNPQLPAAKSVRRSQWHSAPYTRGS 429
Query: 549 FSYIPEGASLTDVENAAAPLPVQEQDTNQRQRRSGGPVQLVVPRLFFAGEHTHSAGIGTI 728
+SY+ G++ D++ A PLP G QL V FAGE TH T
Sbjct: 430 YSYVAVGSTGDDLDLMAQPLP-----------EDGTGTQLQV---LFAGEATHRTFYSTT 475
Query: 729 QGAMMSGLRAASDICKYYFPQLPNILSRL 815
GA++SG R A + + Q+ RL
Sbjct: 476 HGALLSGWREADRLVSLWDSQVEQSRPRL 504
>sp||Q865R1_3 [Segment 3 of 3] Peroxisomal N1-acetyl-spermine/spermidine oxidase
(Polyamine oxidase)
Length = 452
Score = 69.7 bits (169), Expect = 1e-11
Identities = 70/268 (26%), Positives = 110/268 (41%), Gaps = 6/268 (2%)
Frame = +3
Query: 6 FKSDVVVCTLPLGVLKESINNPVGTNSPQFSPPLPEWKVKSINALGFGMFDKVVMCFKER 185
F + VV T+PLG K+ ++ F PPLP KV++I +GFG +K+ + F+E
Sbjct: 219 FPAHHVVVTVPLGFFKKHLDT-------FFEPPLPTEKVEAIRKIGFGTNNKIFLEFEEP 271
Query: 186 FWGSN--NMKVFAQLKSKREQRGEFMQFYAFSRKDASRXXXXXXXXXXXXXXXXKQXXXX 359
FW + +++V + S E +Q F +
Sbjct: 272 FWEPDCQHIQVVWEDMSPLEDTAPELQDAWFKK----------------LIGFWVLPPFQ 315
Query: 360 XXXXXCGEAATAYALEKDLTDAEMGKRALQSLRDIFLKRKIT----VPEPSLIHVYRWTK 527
CG A LE + + + L+SL + R++T +P P + W
Sbjct: 316 ASHVLCGFIA---GLESEFMETLSDEDVLRSLTQVL--RRVTGNPQLPAPRSMLRSCWHS 370
Query: 528 DLHARGVFSYIPEGASLTDVENAAAPLPVQEQDTNQRQRRSGGPVQLVVPRLFFAGEHTH 707
+ RG +SY+ G+S D++ A PLP G QL ++ FAGE TH
Sbjct: 371 APYTRGSYSYVAVGSSGDDMDRLAQPLP-----------SDGKGAQL---QVLFAGEATH 416
Query: 708 SAGIGTIQGAMMSGLRAASDICKYYFPQ 791
GA++SG R A + + PQ
Sbjct: 417 RTFYSPTHGALLSGWREADRLMTLWDPQ 444
>sp|Q21988|AMX1_CAEEL Amine oxidase family member 1
Length = 783
Score = 67.0 bits (162), Expect = 7e-11
Identities = 67/257 (26%), Positives = 102/257 (39%), Gaps = 5/257 (1%)
Frame = +3
Query: 15 DVVVCTLPLGVLKESINNPVGTNSPQFSPPLPEWKVKSINALGFGMFDKVVMCFKERFWG 194
D VV T L VLK + +S F PPLP K K+I+ LG G+ +K+ + F RFW
Sbjct: 565 DKVVITTSLSVLKSN-------HSKMFVPPLPIEKQKAIDDLGAGLIEKIAVKFDRRFWD 617
Query: 195 SNN-----MKVFAQLKSKREQRGEFMQFYAFSRKDASRXXXXXXXXXXXXXXXXKQXXXX 359
+ + + F ++ + R F FY FS KD +
Sbjct: 618 TVDADGLRTEYFGKVSDCKTDRSLFNIFYDFSGKDPNGEDTFVLMSYV------------ 665
Query: 360 XXXXXCGEAATAYALEKDLTDAEMGKRALQSLRDIFLKRKITVPEPSLIHVYRWTKDLHA 539
A L LT++E+ + +LR +F I + H W D
Sbjct: 666 --------TAEHVNLVNVLTESEVADKFCATLRKMFPSAVINPLGHMMSH---WGADRFV 714
Query: 540 RGVFSYIPEGASLTDVENAAAPLPVQEQDTNQRQRRSGGPVQLVVPRLFFAGEHTHSAGI 719
++++P G+ + D Q + + +L+FAGEHT +A
Sbjct: 715 GMSYTFVPFGS---------------DGDATYNQLKKS-----IDEKLYFAGEHTIAAEP 754
Query: 720 GTIQGAMMSGLRAASDI 770
T+ GA +SGLR A I
Sbjct: 755 QTMAGAYISGLREAGQI 771
>sp|O64411|PAO_MAIZE Polyamine oxidase precursor
Length = 500
Score = 63.2 bits (152), Expect = 1e-09
Identities = 61/267 (22%), Positives = 99/267 (37%), Gaps = 8/267 (2%)
Frame = +3
Query: 6 FKSDVVVCTLPLGVLKESINNPVGTNSPQFSPPLPEWKVKSINALGFGMFDKVVMCFKER 185
+ +D V+ + LGVL+ + QF P LP WKV++I ++ K+ + F +
Sbjct: 285 YSADYVMVSASLGVLQSDLI--------QFKPKLPTWKVRAIYQFDMAVYTKIFLKFPRK 336
Query: 186 FWGSNNMKVFAQLKSKREQRGEFMQFYAFSRKDASRXXXXXXXXXXXXXXXXKQXXXXXX 365
FW + F S R RG + + F ++ +Q
Sbjct: 337 FWPEGKGREFFLYASSR--RGYYGVWQEFEKQYPDANVLLVTVTDEESRRIEQQ------ 388
Query: 366 XXXCGEAATAYALEKDLTDAEMGKRALQSLRDIFLKRKITVPEPSLIHVYRWTKDLHARG 545
+D + +Q LR +F + VP+ + I V RW D +G
Sbjct: 389 -----------------SDEQTKAEIMQVLRKMFPGK--DVPDATDILVPRWWSDRFYKG 429
Query: 546 VFSYIPEGASLTDVENAAAPLPVQEQDTNQRQRRSGGPVQLVVPRLFFAGEHTHSAGIGT 725
FS P G + + + AP V R++F GEHT G
Sbjct: 430 TFSNWPVGVNRYEYDQLRAP----------------------VGRVYFTGEHTSEHYNGY 467
Query: 726 IQGAMMSGLRAA--------SDICKYY 782
+ GA +SG+ +A +CKY+
Sbjct: 468 VHGAYLSGIDSAEILINCAQKKMCKYH 494
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 102,486,547
Number of Sequences: 369166
Number of extensions: 2117593
Number of successful extensions: 5277
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 5015
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 5257
length of database: 68,354,980
effective HSP length: 110
effective length of database: 48,034,130
effective search space used: 8982382310
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)