Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_027_D22
(796 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P42356|PI4KA_HUMAN Phosphatidylinositol 4-kinase alpha (... 287 3e-77
sp|P37297|STT4_YEAST Phosphatidylinositol 4-kinase STT4 (PI... 198 1e-50
sp|Q9UBF8|PI4KB_HUMAN Phosphatidylinositol 4-kinase beta (P... 145 9e-35
sp|O08561|PI4KB_RAT Phosphatidylinositol 4-kinase beta (Ptd... 144 4e-34
sp|Q8BKC8|PI4KB_MOUSE Phosphatidylinositol 4-kinase beta (P... 144 4e-34
sp|O02810|PI4KB_BOVIN Phosphatidylinositol 4-kinase beta (P... 143 6e-34
sp|P54677|PI4K_DICDI Phosphatidylinositol 4-kinase (PI4-kin... 142 1e-33
sp|Q9UW20|PIK1_CANAL Phosphatidylinositol 4-kinase PIK1alph... 137 4e-32
sp|P39104|PIK1_YEAST Phosphatidylinositol 4-kinase PIK1 (PI... 130 5e-30
sp|Q9UW24|PIK1A_CANAL Phosphatidylinositol 4-kinase PIK1a (... 129 1e-29
>sp|P42356|PI4KA_HUMAN Phosphatidylinositol 4-kinase alpha (PI4-kinase) (PtdIns-4-kinase)
(PI4K-alpha)
Length = 2044
Score = 287 bits (734), Expect = 3e-77
Identities = 129/204 (63%), Positives = 171/204 (83%)
Frame = +1
Query: 1 VPDSKSRDQIGRTTDSGMYDYFLSLFGEETTPSYQEARRNFVMSMASYSVVCYLLQIKDR 180
+PD SRDQ+GR TD GMYDYF +G+E+T ++Q+AR NF+ SMA+YS++ +LLQIKDR
Sbjct: 1841 IPDCTSRDQLGRQTDFGMYDYFTRQYGDESTLAFQQARYNFIRSMAAYSLLLFLLQIKDR 1900
Query: 181 HNGNIMIDKHGHIIHIDFGFMFESSPGNNMGFEPDIKLTKEMMMVMGGKLDSPAFQWFEQ 360
HNGNIM+DK GHIIHIDFGFMFESSPG N+G+EPDIKLT EM+M+MGGK+++ F+WF +
Sbjct: 1901 HNGNIMLDKKGHIIHIDFGFMFESSPGGNLGWEPDIKLTDEMVMIMGGKMEATPFKWFME 1960
Query: 361 LSVQAYLVLRPYQEALVALVSLMLDSGLPCFRGQTIKLLRQRFTPLMRDRDAANHYLRVL 540
+ V+ YL +RPY +A+V+LV+LMLD+GLPCFRGQTIKLL+ RF+P M +R+AAN ++V+
Sbjct: 1961 MCVRGYLAVRPYMDAVVSLVTLMLDTGLPCFRGQTIKLLKHRFSPNMTEREAANFIMKVI 2020
Query: 541 RTCCDHWRANTYDFIQYFQNQIPY 612
++C R+ TYD IQY+QN IPY
Sbjct: 2021 QSCFLSNRSRTYDMIQYYQNDIPY 2044
>sp|P37297|STT4_YEAST Phosphatidylinositol 4-kinase STT4 (PI4-kinase) (PtdIns-4-kinase)
Length = 1900
Score = 198 bits (504), Expect = 1e-50
Identities = 102/205 (49%), Positives = 133/205 (64%), Gaps = 1/205 (0%)
Frame = +1
Query: 1 VPDSKSRDQIGRTTDSGMYDYFLSLFGEETTPSYQEARRNFVMSMASYSVVCYLLQIKDR 180
+P+S SRD +GR +G+Y+YF S FG E+T +Q AR NFV S+A YSV+ YLLQ KDR
Sbjct: 1696 LPNSVSRDMLGREAVNGLYEYFTSKFGNESTIEFQNARNNFVKSLAGYSVISYLLQFKDR 1755
Query: 181 HNGNIMIDKHGHIIHIDFGFMFESSPGNNMGFEPDIKLTKEMMMVMGGKLDSPAFQWFEQ 360
HNGNIM D GH +HIDFGF+F+ PG KLTKEM+ VMGG +PA+ FE+
Sbjct: 1756 HNGNIMYDDQGHCLHIDFGFIFDIVPGGIKFEAVPFKLTKEMVKVMGGSPQTPAYLDFEE 1815
Query: 361 LSVQAYLVLRPYQEALVALVSLMLDSGLPCFRG-QTIKLLRQRFTPLMRDRDAANHYLRV 537
L ++AYL RP+ EA++ V+ ML SGLPCF+G +TI+ LR RF P D +AA + +
Sbjct: 1816 LCIKAYLAARPHVEAIIECVNPMLGSGLPCFKGHKTIRNLRARFQPQKTDHEAALYMKAL 1875
Query: 538 LRTCCDHWRANTYDFIQYFQNQIPY 612
+R + YD Q N IPY
Sbjct: 1876 IRKSYESIFTKGYDEFQRLTNGIPY 1900
>sp|Q9UBF8|PI4KB_HUMAN Phosphatidylinositol 4-kinase beta (PtdIns 4-kinase) (PI4Kbeta)
(PI4K-beta) (NPIK) (PI4K92)
Length = 816
Score = 145 bits (367), Expect = 9e-35
Identities = 85/205 (41%), Positives = 118/205 (57%), Gaps = 3/205 (1%)
Frame = +1
Query: 1 VPDSKSRDQIGRTTDSGMYDYFLSLFGEETTPSYQEARRNFVMSMASYSVVCYLLQIKDR 180
V ++ S Q+ + + + DYFL G TT ++ A+RNFV S A Y +VCYLLQ+KDR
Sbjct: 613 VVNAVSIHQVKKQSQLSLLDYFLQEHGSYTTEAFLSAQRNFVQSCAGYCLVCYLLQVKDR 672
Query: 181 HNGNIMIDKHGHIIHIDFGFMFESSPGNNMGFEPD-IKLTKEMMMVMGGKLDSPAFQWFE 357
HNGNI++D GHIIHIDFGF+ SSP N+GFE KLT E + VMGG LD F +++
Sbjct: 673 HNGNILLDAEGHIIHIDFGFILSSSP-RNLGFETSAFKLTTEFVDVMGG-LDGDMFNYYK 730
Query: 358 QLSVQAYLVLRPYQEALVALVSLMLD-SGLPCFRG-QTIKLLRQRFTPLMRDRDAANHYL 531
L +Q + R + + +V +V +M S LPCF G TI+ L++RF M +
Sbjct: 731 MLMLQGLIAARKHMDKVVQIVEIMQQGSQLPCFHGSSTIRNLKERFHMSMTEEQLQLLVE 790
Query: 532 RVLRTCCDHWRANTYDFIQYFQNQI 606
+++ YD QY N I
Sbjct: 791 QMVDGSMRSITTKLYDGFQYLTNGI 815
>sp|O08561|PI4KB_RAT Phosphatidylinositol 4-kinase beta (PtdIns 4-kinase) (PI4Kbeta)
(PI4K-beta)
Length = 816
Score = 144 bits (362), Expect = 4e-34
Identities = 84/205 (40%), Positives = 118/205 (57%), Gaps = 3/205 (1%)
Frame = +1
Query: 1 VPDSKSRDQIGRTTDSGMYDYFLSLFGEETTPSYQEARRNFVMSMASYSVVCYLLQIKDR 180
V ++ S Q+ + + + DYFL G TT ++ A+RNFV S A Y +VCYLLQ+KDR
Sbjct: 613 VVNAVSIHQVKKQSQLSLLDYFLQEHGSYTTEAFLSAQRNFVQSCAGYCLVCYLLQVKDR 672
Query: 181 HNGNIMIDKHGHIIHIDFGFMFESSPGNNMGFEPD-IKLTKEMMMVMGGKLDSPAFQWFE 357
HNGNI++D GHIIHIDFGF+ SSP N+GFE KLT E + VMGG L+ F +++
Sbjct: 673 HNGNILLDAEGHIIHIDFGFILSSSP-RNLGFETSAFKLTTEFVDVMGG-LNGDMFNYYK 730
Query: 358 QLSVQAYLVLRPYQEALVALVSLMLD-SGLPCFRG-QTIKLLRQRFTPLMRDRDAANHYL 531
L +Q + R + + +V +V +M S LPCF G TI+ L++RF M +
Sbjct: 731 MLMLQGLIAARKHMDKVVQIVEIMQQGSQLPCFHGSSTIRNLKERFHMSMTEEQLQLLVE 790
Query: 532 RVLRTCCDHWRANTYDFIQYFQNQI 606
+++ YD QY N I
Sbjct: 791 QMVDGSMRSITTKLYDGFQYLTNGI 815
>sp|Q8BKC8|PI4KB_MOUSE Phosphatidylinositol 4-kinase beta (PtdIns 4-kinase) (PI4Kbeta)
(PI4K-beta)
Length = 801
Score = 144 bits (362), Expect = 4e-34
Identities = 84/205 (40%), Positives = 118/205 (57%), Gaps = 3/205 (1%)
Frame = +1
Query: 1 VPDSKSRDQIGRTTDSGMYDYFLSLFGEETTPSYQEARRNFVMSMASYSVVCYLLQIKDR 180
V ++ S Q+ + + + DYFL G TT ++ A+RNFV S A Y +VCYLLQ+KDR
Sbjct: 598 VVNAVSIHQVKKQSQLSLLDYFLQEHGSYTTEAFLSAQRNFVQSCAGYCLVCYLLQVKDR 657
Query: 181 HNGNIMIDKHGHIIHIDFGFMFESSPGNNMGFEPD-IKLTKEMMMVMGGKLDSPAFQWFE 357
HNGNI++D GHIIHIDFGF+ SSP N+GFE KLT E + VMGG L+ F +++
Sbjct: 658 HNGNILLDAEGHIIHIDFGFILSSSP-RNLGFETSAFKLTTEFVDVMGG-LNGDMFNYYK 715
Query: 358 QLSVQAYLVLRPYQEALVALVSLMLD-SGLPCFRG-QTIKLLRQRFTPLMRDRDAANHYL 531
L +Q + R + + +V +V +M S LPCF G TI+ L++RF M +
Sbjct: 716 MLMLQGLIAARKHMDKVVQIVEIMQQGSQLPCFHGSSTIRNLKERFHMSMTEEQLQLLVE 775
Query: 532 RVLRTCCDHWRANTYDFIQYFQNQI 606
+++ YD QY N I
Sbjct: 776 QMVDGSMRSITTKLYDGFQYLTNGI 800
>sp|O02810|PI4KB_BOVIN Phosphatidylinositol 4-kinase beta (PtdIns 4-kinase) (PI4Kbeta)
(PI4K-beta)
Length = 816
Score = 143 bits (360), Expect = 6e-34
Identities = 84/205 (40%), Positives = 117/205 (57%), Gaps = 3/205 (1%)
Frame = +1
Query: 1 VPDSKSRDQIGRTTDSGMYDYFLSLFGEETTPSYQEARRNFVMSMASYSVVCYLLQIKDR 180
V ++ S Q+ + + + DYFL G TT ++ A+RNFV S A Y + CYLLQ+KDR
Sbjct: 613 VVNAVSIHQVKKQSQLSLLDYFLQEHGSYTTEAFLSAQRNFVQSCAGYCLGCYLLQVKDR 672
Query: 181 HNGNIMIDKHGHIIHIDFGFMFESSPGNNMGFEPD-IKLTKEMMMVMGGKLDSPAFQWFE 357
HNGNI++D GHIIHIDFGF+ SSP N+GFE KLT E + VMGG LD F +++
Sbjct: 673 HNGNILLDAEGHIIHIDFGFILSSSP-RNLGFETSAFKLTTEFVDVMGG-LDGDMFNYYK 730
Query: 358 QLSVQAYLVLRPYQEALVALVSLMLD-SGLPCFRG-QTIKLLRQRFTPLMRDRDAANHYL 531
L +Q + R + + +V +V +M S LPCF G TI+ L++RF M +
Sbjct: 731 MLMLQGLIAARKHMDKVVQIVEIMQQGSQLPCFHGSSTIRNLKERFHMSMTEEQLQLLVE 790
Query: 532 RVLRTCCDHWRANTYDFIQYFQNQI 606
+++ YD QY N I
Sbjct: 791 QMVDGSMRSITTKLYDGFQYLTNGI 815
>sp|P54677|PI4K_DICDI Phosphatidylinositol 4-kinase (PI4-kinase) (PtdIns-4-kinase)
(PI4K-alpha)
Length = 1093
Score = 142 bits (357), Expect = 1e-33
Identities = 77/207 (37%), Positives = 127/207 (61%), Gaps = 5/207 (2%)
Frame = +1
Query: 1 VPDSKSRDQIGRTTD--SGMYDYFLSLFGEETTPSYQEARRNFVMSMASYSVVCYLLQIK 174
+PD+ S + ++T + + +YF S +G+ + ++ A+ NF+ SMA+YS+V Y+LQIK
Sbjct: 886 IPDTMSLHNLKKSTPGFTTLLNYFKSTYGDPSGLRFRTAQSNFIESMAAYSIVTYILQIK 945
Query: 175 DRHNGNIMIDKHGHIIHIDFGFMFESSPGNNMGFEPDIKLTKEMMMVMGGKLDSPAFQWF 354
DRHNGNI+IDK GHI+HIDFGF+ +SPGN KLT+E++ VMGG + S FQ+F
Sbjct: 946 DRHNGNILIDKEGHIVHIDFGFILSNSPGNISFESAPFKLTQELVDVMGG-IQSGQFQYF 1004
Query: 355 EQLSVQAYLVLRPYQEALVALVSLMLDS-GLPCFRG--QTIKLLRQRFTPLMRDRDAANH 525
+ L V+ + R + +++L+ +M+ + CF G + I+ L+ RF + +R+ +
Sbjct: 1005 KVLCVRGLIEARKQVDKIISLIEIMMSGPKMSCFVGGKEVIEQLKARFFLDVNERECSTL 1064
Query: 526 YLRVLRTCCDHWRANTYDFIQYFQNQI 606
++ DH++ YD Q + N I
Sbjct: 1065 VENLISYSIDHFKTRYYDKYQSWLNGI 1091
>sp|Q9UW20|PIK1_CANAL Phosphatidylinositol 4-kinase PIK1alpha (PI4-kinase)
(PtdIns-4-kinase)
Length = 977
Score = 137 bits (344), Expect = 4e-32
Identities = 75/158 (47%), Positives = 103/158 (65%), Gaps = 4/158 (2%)
Frame = +1
Query: 52 MYDYFLSLFGEETTPSYQEARRNFVMSMASYSVVCYLLQIKDRHNGNIMIDKHGHIIHID 231
+ DYF S+FG + S++ A++NF S+A+YS++CY+LQIKDRHNGNIM+D GHIIHID
Sbjct: 788 LLDYFHSVFGSPNSTSFRTAQQNFAKSLAAYSIICYVLQIKDRHNGNIMVDGDGHIIHID 847
Query: 232 FGFMFESSPGNNMGFE-PDIKLTKEMMMVMGGKLDSPAFQWFEQLSVQAYLVLRPYQEAL 408
FGF+ +SPG ++GFE KLT E + ++GG +DS + F L Q + LR E +
Sbjct: 848 FGFLLSNSPG-SVGFEAAPFKLTVEYVELLGG-VDSEIYSQFVYLCKQCFKSLRDNSEEI 905
Query: 409 VALVSLM-LDSGLPCFRG--QTIKLLRQRFTPLMRDRD 513
+ +V LM DS LPCF T LL+QR + D D
Sbjct: 906 IEIVELMQKDSTLPCFNNGENTSVLLKQRLQLQLNDED 943
>sp|P39104|PIK1_YEAST Phosphatidylinositol 4-kinase PIK1 (PI4-kinase) (PtdIns-4-kinase)
Length = 1066
Score = 130 bits (326), Expect = 5e-30
Identities = 71/152 (46%), Positives = 100/152 (65%), Gaps = 4/152 (2%)
Frame = +1
Query: 46 SGMYDYFLSLFGEETTPSYQEARRNFVMSMASYSVVCYLLQIKDRHNGNIMIDKHGHIIH 225
+ + D+FL FG Y+ A+ NF S+A+YSV+CYLLQ+KDRHNGNIMID GH+ H
Sbjct: 875 ASLNDHFLRAFGNPNGFKYRRAQDNFASSLAAYSVICYLLQVKDRHNGNIMIDNEGHVSH 934
Query: 226 IDFGFMFESSPGNNMGFE-PDIKLTKEMMMVMGGKLDSPAFQWFEQLSVQAYLVLRPYQE 402
IDFGFM +SPG ++GFE KLT E + ++GG ++ AF+ F +L+ ++ LR Y +
Sbjct: 935 IDFGFMLSNSPG-SVGFEAAPFKLTYEYIELLGG-VEGEAFKKFVELTKSSFKALRKYAD 992
Query: 403 ALVALVSLM-LDSGLPCFRG--QTIKLLRQRF 489
+V++ +M D+ PCF QT LRQRF
Sbjct: 993 QIVSMCEIMQKDNMQPCFDAGEQTSVQLRQRF 1024
>sp|Q9UW24|PIK1A_CANAL Phosphatidylinositol 4-kinase PIK1a (PI4-kinase) (PtdIns-4-kinase)
Length = 956
Score = 129 bits (323), Expect = 1e-29
Identities = 73/156 (46%), Positives = 98/156 (62%), Gaps = 4/156 (2%)
Frame = +1
Query: 58 DYFLSLFGEETTPSYQEARRNFVMSMASYSVVCYLLQIKDRHNGNIMIDKHGHIIHIDFG 237
DYF L+G + Y +A+ NF +S+ASYS++CY+LQIKDRHNGNIM+D GHIIHIDFG
Sbjct: 769 DYFQKLYGSVDSSKYVKAQENFAISLASYSIICYVLQIKDRHNGNIMLDHEGHIIHIDFG 828
Query: 238 FMFESSPGNNMGFE-PDIKLTKEMMMVMGGKLDSPAFQWFEQLSVQAYLVLRPYQEALVA 414
F+ +SPG ++GFE KLT E + V+GG L+S A+ F + LR +V+
Sbjct: 829 FLLSNSPG-SVGFEAAPFKLTSEYVEVLGG-LESKAYLKFVDTCKNCFKALRKEWGQIVS 886
Query: 415 LVSLM-LDSGLPCFRG--QTIKLLRQRFTPLMRDRD 513
+V LM S LPCF T LL+QR + D +
Sbjct: 887 IVELMQKGSSLPCFNNGDNTSVLLQQRLQLHLSDEE 922
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 82,060,519
Number of Sequences: 369166
Number of extensions: 1530417
Number of successful extensions: 4077
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 3941
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 4036
length of database: 68,354,980
effective HSP length: 109
effective length of database: 48,218,865
effective search space used: 7473924075
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)