Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_027_D09
(687 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P31153|METK_HUMAN S-adenosylmethionine synthetase gamma ... 232 8e-61
sp|P18298|METK_RAT S-adenosylmethionine synthetase gamma fo... 230 2e-60
sp|Q00266|METL_HUMAN S-adenosylmethionine synthetase alpha ... 229 5e-60
sp|P13444|METL_RAT S-adenosylmethionine synthetase alpha an... 226 6e-59
sp|P40320|METK_DROME S-adenosylmethionine synthetase (Methi... 208 1e-53
sp|P19358|METL_YEAST S-adenosylmethionine synthetase 2 (Met... 206 4e-53
sp|P50306|METL_CAEEL Probable S-adenosylmethionine syntheta... 205 8e-53
sp|P50305|METK_CAEEL Probable S-adenosylmethionine syntheta... 205 1e-52
sp|P48466|METK_NEUCR S-adenosylmethionine synthetase (Methi... 204 2e-52
sp|P10659|METK_YEAST S-adenosylmethionine synthetase 1 (Met... 203 4e-52
>sp|P31153|METK_HUMAN S-adenosylmethionine synthetase gamma form (Methionine
adenosyltransferase) (AdoMet synthetase) (MAT-II)
Length = 395
Score = 232 bits (591), Expect = 8e-61
Identities = 116/174 (66%), Positives = 130/174 (74%)
Frame = +1
Query: 7 LLSDVIRKVIPDHYLDDDTIYHLNPSGRFVIGGPQGDAGLTGRKIIVDTYXXXXXXXXXX 186
L VI+ V+P YLD+DTIYHL PSGRFVIGGPQGDAGLTGRKIIVDTY
Sbjct: 222 LKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGA 281
Query: 187 XXXKDFSKVDRSAAYAARWVAKSLVKANLCRRVLVQVSYAIGISHPLSIXXXXXXXXXXX 366
KD++KVDRSAAYAARWVAKSLVK LCRRVLVQVSYAIG+SHPLSI
Sbjct: 282 FSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKS 341
Query: 367 XXXLLQIVVANFDLRPGHIVKELNLRHPIYKKTACYGHFGRDEFSWEKPKKLKF 528
LL+IV NFDLRPG IV++L+L+ PIY++TA YGHFGRD F WE PKKLK+
Sbjct: 342 ERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY 395
>sp|P18298|METK_RAT S-adenosylmethionine synthetase gamma form (Methionine
adenosyltransferase) (AdoMet synthetase) (MAT-II)
Length = 395
Score = 230 bits (587), Expect = 2e-60
Identities = 115/174 (66%), Positives = 130/174 (74%)
Frame = +1
Query: 7 LLSDVIRKVIPDHYLDDDTIYHLNPSGRFVIGGPQGDAGLTGRKIIVDTYXXXXXXXXXX 186
L +I+ V+P YLD+DTIYHL PSGRFVIGGPQGDAGLTGRKIIVDTY
Sbjct: 222 LKEKLIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGA 281
Query: 187 XXXKDFSKVDRSAAYAARWVAKSLVKANLCRRVLVQVSYAIGISHPLSIXXXXXXXXXXX 366
KD++KVDRSAAYAARWVAKSLVK LCRRVLVQVSYAIG+SHPLSI
Sbjct: 282 FSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKS 341
Query: 367 XXXLLQIVVANFDLRPGHIVKELNLRHPIYKKTACYGHFGRDEFSWEKPKKLKF 528
LL+IV NFDLRPG IV++L+L+ PIY++TA YGHFGRD F WE PKKLK+
Sbjct: 342 ERELLEIVKNNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY 395
>sp|Q00266|METL_HUMAN S-adenosylmethionine synthetase alpha and beta forms (Methionine
adenosyltransferase) (AdoMet synthetase) (MAT-I/III)
Length = 395
Score = 229 bits (584), Expect = 5e-60
Identities = 114/174 (65%), Positives = 129/174 (74%)
Frame = +1
Query: 7 LLSDVIRKVIPDHYLDDDTIYHLNPSGRFVIGGPQGDAGLTGRKIIVDTYXXXXXXXXXX 186
L VIR V+P YLD+DT+YHL PSGRFVIGGPQGDAG+TGRKIIVDTY
Sbjct: 222 LKEQVIRAVVPAKYLDEDTVYHLQPSGRFVIGGPQGDAGVTGRKIIVDTYGGWGAHGGGA 281
Query: 187 XXXKDFSKVDRSAAYAARWVAKSLVKANLCRRVLVQVSYAIGISHPLSIXXXXXXXXXXX 366
KD++KVDRSAAYAARWVAKSLVKA LCRRVLVQVSYAIG++ PLSI
Sbjct: 282 FSGKDYTKVDRSAAYAARWVAKSLVKAGLCRRVLVQVSYAIGVAEPLSISIFTYGTSQKT 341
Query: 367 XXXLLQIVVANFDLRPGHIVKELNLRHPIYKKTACYGHFGRDEFSWEKPKKLKF 528
LL +V NFDLRPG IV++L+L+ PIY+KTACYGHFGR EF WE P+KL F
Sbjct: 342 ERELLDVVHKNFDLRPGVIVRDLDLKKPIYQKTACYGHFGRSEFPWEVPRKLVF 395
>sp|P13444|METL_RAT S-adenosylmethionine synthetase alpha and beta forms (Methionine
adenosyltransferase) (AdoMet synthetase) (MAT-I/III)
Length = 397
Score = 226 bits (575), Expect = 6e-59
Identities = 115/175 (65%), Positives = 130/175 (74%), Gaps = 1/175 (0%)
Frame = +1
Query: 7 LLSDVIRKVIPDHYLDDDTIYHLNPSGRFVIGGPQGDAGLTGRKIIVDTYXXXXXXXXXX 186
L VI+ V+P YLD+DTIYHL PSGRFVIGGPQGDAG+TGRKIIVDTY
Sbjct: 223 LKEQVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGVTGRKIIVDTYGGWGAHGGGA 282
Query: 187 XXXKDFSKVDRSAAYAARWVAKSLVKANLCRRVLVQVSYAIGISHPLSI-XXXXXXXXXX 363
KD++KVDRSAAYAARWVAKSLVKA LCRRVLVQVSYAIG++ PLSI
Sbjct: 283 FSGKDYTKVDRSAAYAARWVAKSLVKAGLCRRVLVQVSYAIGVAEPLSISIFTYGTSKKT 342
Query: 364 XXXXLLQIVVANFDLRPGHIVKELNLRHPIYKKTACYGHFGRDEFSWEKPKKLKF 528
LL++V NFDLRPG IV++L+L+ PIY+KTACYGHFGR EF WE PKKL F
Sbjct: 343 ERDELLEVVNKNFDLRPGVIVRDLDLKKPIYQKTACYGHFGRSEFPWEVPKKLVF 397
>sp|P40320|METK_DROME S-adenosylmethionine synthetase (Methionine adenosyltransferase)
(AdoMet synthetase)
Length = 408
Score = 208 bits (529), Expect = 1e-53
Identities = 105/173 (60%), Positives = 123/173 (71%)
Frame = +1
Query: 7 LLSDVIRKVIPDHYLDDDTIYHLNPSGRFVIGGPQGDAGLTGRKIIVDTYXXXXXXXXXX 186
++ V++ VIP Y+D +TI H+NP G FVIGGP GDAGLTGRKIIVDTY
Sbjct: 233 VMEKVVKVVIPAKYIDANTIVHINPCGLFVIGGPMGDAGLTGRKIIVDTYGGWGAHGGGA 292
Query: 187 XXXKDFSKVDRSAAYAARWVAKSLVKANLCRRVLVQVSYAIGISHPLSIXXXXXXXXXXX 366
KDF+KVDRSAAYAARWVAKSLVKA LC+R LVQVSYAIG++ PLSI
Sbjct: 293 FSGKDFTKVDRSAAYAARWVAKSLVKAGLCKRCLVQVSYAIGLAEPLSITVFDYGTSHKS 352
Query: 367 XXXLLQIVVANFDLRPGHIVKELNLRHPIYKKTACYGHFGRDEFSWEKPKKLK 525
LL I+ NFDLRPG IVK+LNLR PIY++T+ YGHFGR FSWE+ K L+
Sbjct: 353 QKELLDIIRRNFDLRPGKIVKDLNLRQPIYQRTSTYGHFGRAGFSWEEAKPLE 405
>sp|P19358|METL_YEAST S-adenosylmethionine synthetase 2 (Methionine adenosyltransferase
2) (AdoMet synthetase 2)
Length = 384
Score = 206 bits (525), Expect = 4e-53
Identities = 104/174 (59%), Positives = 121/174 (69%)
Frame = +1
Query: 7 LLSDVIRKVIPDHYLDDDTIYHLNPSGRFVIGGPQGDAGLTGRKIIVDTYXXXXXXXXXX 186
L D++ KVIP LD++T Y + PSGRFVIGGPQGDAGLTGRKIIVD Y
Sbjct: 211 LQKDIVEKVIPKDMLDENTKYFIQPSGRFVIGGPQGDAGLTGRKIIVDAYGGASSVGGGA 270
Query: 187 XXXKDFSKVDRSAAYAARWVAKSLVKANLCRRVLVQVSYAIGISHPLSIXXXXXXXXXXX 366
KD+SKVDRSAAYAARWVAKSLV A LC+RV VQ SYAIGI+ PLS+
Sbjct: 271 FSGKDYSKVDRSAAYAARWVAKSLVAAGLCKRVQVQFSYAIGIAEPLSLHVDTYGTATKS 330
Query: 367 XXXLLQIVVANFDLRPGHIVKELNLRHPIYKKTACYGHFGRDEFSWEKPKKLKF 528
+++I+ NFDLRPG +VKEL+L PIY TA YGHF E+SWEKPKKL+F
Sbjct: 331 DDEIIEIIKKNFDLRPGVLVKELDLARPIYLPTASYGHFTNQEYSWEKPKKLEF 384
>sp|P50306|METL_CAEEL Probable S-adenosylmethionine synthetase C06E7.3 (Methionine
adenosyltransferase) (AdoMet synthetase)
Length = 404
Score = 205 bits (522), Expect = 8e-53
Identities = 105/175 (60%), Positives = 121/175 (69%)
Frame = +1
Query: 1 KHLLSDVIRKVIPDHYLDDDTIYHLNPSGRFVIGGPQGDAGLTGRKIIVDTYXXXXXXXX 180
K L+ VI+ VIP + +DD TIYHLNP G F+IGGP GDAGLTGRKIIVDTY
Sbjct: 208 KELIEKVIKAVIPANLIDDKTIYHLNPCGSFIIGGPMGDAGLTGRKIIVDTYGGWGAHGG 267
Query: 181 XXXXXKDFSKVDRSAAYAARWVAKSLVKANLCRRVLVQVSYAIGISHPLSIXXXXXXXXX 360
KD +KVDRSAAYAARWVAKSLVKA LCRR LVQVSYAIG++ PLS+
Sbjct: 268 GAFSGKDPTKVDRSAAYAARWVAKSLVKAGLCRRCLVQVSYAIGVAKPLSVMVFSFGTSA 327
Query: 361 XXXXXLLQIVVANFDLRPGHIVKELNLRHPIYKKTACYGHFGRDEFSWEKPKKLK 525
LL IV NFDLRPG I+K L+L+ PIY+ TA GHFG + F WE+P+ LK
Sbjct: 328 LSEEDLLTIVNDNFDLRPGKIIKNLDLKRPIYEPTAENGHFGHNNFPWEQPRNLK 382
>sp|P50305|METK_CAEEL Probable S-adenosylmethionine synthetase C06E7.1 (Methionine
adenosyltransferase) (AdoMet synthetase)
Length = 404
Score = 205 bits (521), Expect = 1e-52
Identities = 104/175 (59%), Positives = 124/175 (70%)
Frame = +1
Query: 1 KHLLSDVIRKVIPDHYLDDDTIYHLNPSGRFVIGGPQGDAGLTGRKIIVDTYXXXXXXXX 180
K L+ VI+ VIP + +DD TIYHLNP G F+IGGP GDAGLTGRKIIVDTY
Sbjct: 208 KELIEKVIKAVIPANLIDDKTIYHLNPCGSFIIGGPMGDAGLTGRKIIVDTYGGWGAHGG 267
Query: 181 XXXXXKDFSKVDRSAAYAARWVAKSLVKANLCRRVLVQVSYAIGISHPLSIXXXXXXXXX 360
KD +KVDRSAAYAARWVAKSLVK+ LCRR LVQVSYAIG++ PLS+
Sbjct: 268 GAFSGKDPTKVDRSAAYAARWVAKSLVKSGLCRRCLVQVSYAIGVAKPLSVMVFSFGTSA 327
Query: 361 XXXXXLLQIVVANFDLRPGHIVKELNLRHPIYKKTACYGHFGRDEFSWEKPKKLK 525
LL+IV NFDLRPG I+K+L+L+ PIY+ TA GHFG +EF WE+P+ L+
Sbjct: 328 LNEGELLKIVNDNFDLRPGMIIKDLDLKKPIYEPTAENGHFGHNEFPWEQPRHLQ 382
>sp|P48466|METK_NEUCR S-adenosylmethionine synthetase (Methionine adenosyltransferase)
(AdoMet synthetase)
Length = 395
Score = 204 bits (519), Expect = 2e-52
Identities = 106/177 (59%), Positives = 122/177 (68%), Gaps = 1/177 (0%)
Frame = +1
Query: 1 KHLLSDVIRKVIPDHYLDDDTIYHLNPSGRFVIGGPQGDAGLTGRKIIVDTYXXXXXXXX 180
K +L +I+ IP YLD+ T+YH+ PSG FVIGGPQGDAGLTGRKIIVDTY
Sbjct: 219 KEILEKIIKTTIPAKYLDEKTVYHIQPSGLFVIGGPQGDAGLTGRKIIVDTYGGWGAHGG 278
Query: 181 XXXXXKDFSKVDRSAAYAARWVAKSLVKANLCRRVLVQVSYAIGISHPLSIXXXXXXXXX 360
KDFSKVDRSAAY RW+AKSLV A L RR LVQ+SYAIG++ PLSI
Sbjct: 279 GAFSGKDFSKVDRSAAYVGRWIAKSLVAAGLARRALVQLSYAIGVAEPLSIYVDTYGTSD 338
Query: 361 XXXXXLLQIVVANFDLRPGHIVKELNLRHPIYKKTACYGHFGRDE-FSWEKPKKLKF 528
L+QI+ NFDLRPG IVKEL+L PIY +TA GHFG ++ FSWEKPK LKF
Sbjct: 339 KTSEELVQIIRNNFDLRPGVIVKELDLAKPIYLQTAKNGHFGTNQSFSWEKPKALKF 395
>sp|P10659|METK_YEAST S-adenosylmethionine synthetase 1 (Methionine adenosyltransferase
1) (AdoMet synthetase 1)
Length = 382
Score = 203 bits (516), Expect = 4e-52
Identities = 104/174 (59%), Positives = 119/174 (68%)
Frame = +1
Query: 7 LLSDVIRKVIPDHYLDDDTIYHLNPSGRFVIGGPQGDAGLTGRKIIVDTYXXXXXXXXXX 186
L S++I KVIP LD++T Y + PSGRFVIGGPQGDAGLTGRKIIVD Y
Sbjct: 209 LKSEIIEKVIPRDMLDENTKYFIQPSGRFVIGGPQGDAGLTGRKIIVDAYGGASSVGGGA 268
Query: 187 XXXKDFSKVDRSAAYAARWVAKSLVKANLCRRVLVQVSYAIGISHPLSIXXXXXXXXXXX 366
KD+SKVDRSAAYAARWVAKSLV A LC+RV VQ SYAIGI+ PLS+
Sbjct: 269 FSGKDYSKVDRSAAYAARWVAKSLVAAGLCKRVQVQFSYAIGIAEPLSLHVDTYGTATKS 328
Query: 367 XXXLLQIVVANFDLRPGHIVKELNLRHPIYKKTACYGHFGRDEFSWEKPKKLKF 528
++ I+ NFDLRPG +VKEL+L PIY TA YGHF E+ WEKPK LKF
Sbjct: 329 DEEIIDIISKNFDLRPGVLVKELDLARPIYLPTASYGHFTNQEYPWEKPKTLKF 382
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 72,877,784
Number of Sequences: 369166
Number of extensions: 1375977
Number of successful extensions: 3462
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 3220
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 3378
length of database: 68,354,980
effective HSP length: 107
effective length of database: 48,588,335
effective search space used: 5879188535
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)