Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_027_D08
(790 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q26636|CATL_SARPE Cathepsin L precursor [Contains: Cathe... 272 7e-73
sp|Q95029|CATL_DROME Cathepsin L precursor (Cysteine protei... 271 1e-72
sp|O60911|CATL2_HUMAN Cathepsin L2 precursor (Cathepsin V) ... 270 3e-72
sp|Q10991|CATL_SHEEP Cathepsin L [Contains: Cathepsin L hea... 270 3e-72
sp|P07711|CATL_HUMAN Cathepsin L precursor (Major excreted ... 270 3e-72
sp|Q9GL24|CATL_CANFA Cathepsin L precursor [Contains: Cathe... 268 2e-71
sp|P25975|CATL_BOVIN Cathepsin L precursor [Contains: Cathe... 266 6e-71
sp|P25782|CYSP2_HOMAM Digestive cysteine proteinase 2 precu... 263 4e-70
sp|P25784|CYSP3_HOMAM Digestive cysteine proteinase 3 precu... 258 1e-68
sp|Q28944|CATL_PIG Cathepsin L precursor [Contains: Catheps... 258 1e-68
>sp|Q26636|CATL_SARPE Cathepsin L precursor [Contains: Cathepsin L heavy chain; Cathepsin
L light chain]
Length = 339
Score = 272 bits (696), Expect = 7e-73
Identities = 135/239 (56%), Positives = 164/239 (68%), Gaps = 2/239 (0%)
Frame = +2
Query: 11 IMKTKPTLEGSTYMAPENIGVLPASVDWRQKGYVTPVKNQQQCGSCWSFSATGSLEGQYF 190
+M+ + L G+TY+ P ++ V P SVDWR+ G VT VK+Q CGSCW+FS+TG+LEGQ+F
Sbjct: 102 LMRERTGLVGATYIPPAHVTV-PKSVDWREHGAVTGVKDQGHCGSCWAFSSTGALEGQHF 160
Query: 191 RKNNRLISFSEQQLVDCSXXXXXXXXXXXLMDNAFRYIKDQG-IESEGDYPYTATDGTCK 367
RK L+S SEQ LVDCS LMDNAFRYIKD G I++E YPY D +C
Sbjct: 161 RKAGVLVSLSEQNLVDCSTKYGNNGCNGGLMDNAFRYIKDNGGIDTEKSYPYEGIDDSCH 220
Query: 368 RNPSKIVTKCTGFTDIQSQNETDLANAVATVGPVSVAIDAGHASFQLYKSGIYNEESCST 547
N + I TGF DI +E + AVAT+GPVSVAIDA H SFQLY G+YNE C
Sbjct: 221 FNKATIGATDTGFVDIPEGDEEKMKKAVATMGPVSVAIDASHESFQLYSEGVYNEPECDE 280
Query: 548 TQLDHGVLAVGYGT-QIGKKYWIVKNSWDVTWGESGYIKMSKDKKNQCGIATMASYPLV 721
LDHGVL VGYGT + G YW+VKNSW TWGE GYIKM++++ NQCGIAT +SYP V
Sbjct: 281 QNLDHGVLVVGYGTDESGMDYWLVKNSWGTTWGEQGYIKMARNQNNQCGIATASSYPTV 339
>sp|Q95029|CATL_DROME Cathepsin L precursor (Cysteine proteinase 1) [Contains: Cathepsin
L heavy chain; Cathepsin L light chain]
Length = 341
Score = 271 bits (693), Expect = 1e-72
Identities = 132/233 (56%), Positives = 164/233 (70%), Gaps = 2/233 (0%)
Frame = +2
Query: 29 TLEGSTYMAPENIGVLPASVDWRQKGYVTPVKNQQQCGSCWSFSATGSLEGQYFRKNNRL 208
+ +G T+++P ++ LP SVDWR KG VT VK+Q CGSCW+FS+TG+LEGQ+FRK+ L
Sbjct: 110 SFKGVTFISPAHV-TLPKSVDWRTKGAVTAVKDQGHCGSCWAFSSTGALEGQHFRKSGVL 168
Query: 209 ISFSEQQLVDCSXXXXXXXXXXXLMDNAFRYIKDQ-GIESEGDYPYTATDGTCKRNPSKI 385
+S SEQ LVDCS LMDNAFRYIKD GI++E YPY A D +C N +
Sbjct: 169 VSLSEQNLVDCSTKYGNNGCNGGLMDNAFRYIKDNGGIDTEKSYPYEAIDDSCHFNKGTV 228
Query: 386 VTKCTGFTDIQSQNETDLANAVATVGPVSVAIDAGHASFQLYKSGIYNEESCSTTQLDHG 565
GFTDI +E +A AVATVGPVSVAIDA H SFQ Y G+YNE C LDHG
Sbjct: 229 GATDRGFTDIPQGDEKKMAEAVATVGPVSVAIDASHESFQFYSEGVYNEPQCDAQNLDHG 288
Query: 566 VLAVGYGT-QIGKKYWIVKNSWDVTWGESGYIKMSKDKKNQCGIATMASYPLV 721
VL VG+GT + G+ YW+VKNSW TWG+ G+IKM ++K+NQCGIA+ +SYPLV
Sbjct: 289 VLVVGFGTDESGEDYWLVKNSWGTTWGDKGFIKMLRNKENQCGIASASSYPLV 341
>sp|O60911|CATL2_HUMAN Cathepsin L2 precursor (Cathepsin V) (Cathepsin U)
Length = 334
Score = 270 bits (691), Expect = 3e-72
Identities = 134/244 (54%), Positives = 161/244 (65%), Gaps = 5/244 (2%)
Frame = +2
Query: 5 LGIMKTKPTLEGSTYMAPENIGVLPASVDWRQKGYVTPVKNQQQCGSCWSFSATGSLEGQ 184
+G + + +G + P + LP SVDWR+KGYVTPVKNQ+QCGSCW+FSATG+LEGQ
Sbjct: 92 MGCFRNQKFRKGKVFREPLFLD-LPKSVDWRKKGYVTPVKNQKQCGSCWAFSATGALEGQ 150
Query: 185 YFRKNNRLISFSEQQLVDCSXXXXXXXXXXXLMDNAFRYIKDQ-GIESEGDYPYTATDGT 361
FRK +L+S SEQ LVDCS M AF+Y+K+ G++SE YPY A D
Sbjct: 151 MFRKTGKLVSLSEQNLVDCSRPQGNQGCNGGFMARAFQYVKENGGLDSEESYPYVAVDEI 210
Query: 362 CKRNPSKIVTKCTGFTDIQSQNETDLANAVATVGPVSVAIDAGHASFQLYKSGIYNEESC 541
CK P V TGFT + E L AVATVGP+SVA+DAGH+SFQ YKSGIY E C
Sbjct: 211 CKYRPENSVANDTGFTVVAPGKEKALMKAVATVGPISVAMDAGHSSFQFYKSGIYFEPDC 270
Query: 542 STTQLDHGVLAVGYG----TQIGKKYWIVKNSWDVTWGESGYIKMSKDKKNQCGIATMAS 709
S+ LDHGVL VGYG KYW+VKNSW WG +GY+K++KDK N CGIAT AS
Sbjct: 271 SSKNLDHGVLVVGYGFEGANSNNSKYWLVKNSWGPEWGSNGYVKIAKDKNNHCGIATAAS 330
Query: 710 YPLV 721
YP V
Sbjct: 331 YPNV 334
>sp|Q10991|CATL_SHEEP Cathepsin L [Contains: Cathepsin L heavy chain; Cathepsin L light
chain]
Length = 217
Score = 270 bits (691), Expect = 3e-72
Identities = 134/218 (61%), Positives = 154/218 (70%), Gaps = 2/218 (0%)
Frame = +2
Query: 74 LPASVDWRQKGYVTPVKNQQQCGSCWSFSATGSLEGQYFRKNNRLISFSEQQLVDCSXXX 253
+P SVDW +KGYVTPVKNQ QCGSCW+FSATG+LEGQ FRK +L+S SEQ LVD S
Sbjct: 1 VPKSVDWTKKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGKLVSLSEQNLVDSSRPQ 60
Query: 254 XXXXXXXXLMDNAFRYIKDQ-GIESEGDYPYTATDGTCKRNPSKIVTKCTGFTDIQSQNE 430
LMDNAF+YIK+ G++SE YPY ATD +C P K TGF DI Q E
Sbjct: 61 GNQGCNGGLMDNAFQYIKENGGLDSEESYPYEATDTSCNYKPEYSAAKDTGFVDI-PQRE 119
Query: 431 TDLANAVATVGPVSVAIDAGHASFQLYKSGIYNEESCSTTQLDHGVLAVGYGTQ-IGKKY 607
L AVATVGP+SVAIDAGH+SFQ YKSGIY + CS+ LDHGVL VGYG + K+
Sbjct: 120 KALMKAVATVGPISVAIDAGHSSFQFYKSGIYYDPDCSSKDLDHGVLVVGYGFEGTNNKF 179
Query: 608 WIVKNSWDVTWGESGYIKMSKDKKNQCGIATMASYPLV 721
WIVKNSW WG GY+KM+KD+ N CGIAT ASYP V
Sbjct: 180 WIVKNSWGPEWGNKGYVKMAKDQNNHCGIATAASYPTV 217
>sp|P07711|CATL_HUMAN Cathepsin L precursor (Major excreted protein) (MEP) [Contains:
Cathepsin L heavy chain; Cathepsin L light chain]
Length = 333
Score = 270 bits (690), Expect = 3e-72
Identities = 134/220 (60%), Positives = 154/220 (70%), Gaps = 5/220 (2%)
Frame = +2
Query: 77 PASVDWRQKGYVTPVKNQQQCGSCWSFSATGSLEGQYFRKNNRLISFSEQQLVDCSXXXX 256
P SVDWR+KGYVTPVKNQ QCGSCW+FSATG+LEGQ FRK RLIS SEQ LVDCS
Sbjct: 115 PRSVDWREKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGRLISLSEQNLVDCSGPQG 174
Query: 257 XXXXXXXLMDNAFRYIKDQ-GIESEGDYPYTATDGTCKRNPSKIVTKCTGFTDIQSQNET 433
LMD AF+Y++D G++SE YPY AT+ +CK NP V TGF DI Q E
Sbjct: 175 NEGCNGGLMDYAFQYVQDNGGLDSEESYPYEATEESCKYNPKYSVANDTGFVDIPKQ-EK 233
Query: 434 DLANAVATVGPVSVAIDAGHASFQLYKSGIYNEESCSTTQLDHGVLAVGYGTQI----GK 601
L AVATVGP+SVAIDAGH SF YK GIY E CS+ +DHGVL VGYG +
Sbjct: 234 ALMKAVATVGPISVAIDAGHESFLFYKEGIYFEPDCSSEDMDHGVLVVGYGFESTESDNN 293
Query: 602 KYWIVKNSWDVTWGESGYIKMSKDKKNQCGIATMASYPLV 721
KYW+VKNSW WG GY+KM+KD++N CGIA+ ASYP V
Sbjct: 294 KYWLVKNSWGEEWGMGGYVKMAKDRRNHCGIASAASYPTV 333
>sp|Q9GL24|CATL_CANFA Cathepsin L precursor [Contains: Cathepsin L heavy chain; Cathepsin
L light chain]
Length = 333
Score = 268 bits (684), Expect = 2e-71
Identities = 134/221 (60%), Positives = 153/221 (69%), Gaps = 5/221 (2%)
Frame = +2
Query: 74 LPASVDWRQKGYVTPVKNQQQCGSCWSFSATGSLEGQYFRKNNRLISFSEQQLVDCSXXX 253
+P SVDWR+KGYVTPVKNQ QCGSCW+FSATG+LEGQ FRK +L+S SEQ LVDCS
Sbjct: 114 IPKSVDWREKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGKLVSLSEQNLVDCSRAQ 173
Query: 254 XXXXXXXXLMDNAFRYIKDQ-GIESEGDYPYTATD-GTCKRNPSKIVTKCTGFTDIQSQN 427
LMDNAFRY+KD G++SE YPY D TC P TGF D+ Q
Sbjct: 174 GNEGCNGGLMDNAFRYVKDNGGLDSEESYPYLGRDTETCNYKPECSAANDTGFVDL-PQR 232
Query: 428 ETDLANAVATVGPVSVAIDAGHASFQLYKSGIYNEESCSTTQLDHGVLAVGY---GTQIG 598
E L AVAT+GP+SVAIDAGH SFQ YKSGIY + CS+ LDHGVL VGY GT
Sbjct: 233 EKALMKAVATLGPISVAIDAGHQSFQFYKSGIYFDPDCSSKDLDHGVLVVGYGFEGTDSN 292
Query: 599 KKYWIVKNSWDVTWGESGYIKMSKDKKNQCGIATMASYPLV 721
K+WIVKNSW WG +GY+KM+KD+ N CGIAT ASYP V
Sbjct: 293 NKFWIVKNSWGPEWGWNGYVKMAKDQNNHCGIATAASYPTV 333
>sp|P25975|CATL_BOVIN Cathepsin L precursor [Contains: Cathepsin L heavy chain; Cathepsin
L light chain]
Length = 334
Score = 266 bits (679), Expect = 6e-71
Identities = 135/222 (60%), Positives = 153/222 (68%), Gaps = 6/222 (2%)
Frame = +2
Query: 74 LPASVDWRQKGYVTPVKNQQQCGSCWSFSATGSLEGQYFRKNNRLISFSEQQLVDCSXXX 253
+P SVDW +KGYVTPVKNQ QCGSCW+FSATG+LEGQ FRK +L+S SEQ LVDCS
Sbjct: 114 VPKSVDWTKKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGKLVSLSEQNLVDCSRAQ 173
Query: 254 XXXXXXXXLMDNAFRYIKDQ-GIESEGDYPYTATD-GTCKRNPSKIVTKCTGFTDIQSQN 427
LMDNAF+YIKD G++SE YPY ATD +C P TGF DI Q
Sbjct: 174 GNQGCNGGLMDNAFQYIKDNGGLDSEESYPYLATDTNSCNYKPECSAANDTGFVDI-PQR 232
Query: 428 ETDLANAVATVGPVSVAIDAGHASFQLYKSGIYNEESCSTTQLDHGVLAVGYGTQ----I 595
E L AVATVGP+SVAIDAGH SFQ YKSGIY + CS LDHGVL VGYG +
Sbjct: 233 EKALMKAVATVGPISVAIDAGHTSFQFYKSGIYYDPDCSCKDLDHGVLVVGYGFEGTDSN 292
Query: 596 GKKYWIVKNSWDVTWGESGYIKMSKDKKNQCGIATMASYPLV 721
K+WIVKNSW WG +GY+KM+KD+ N CGIAT ASYP V
Sbjct: 293 NNKFWIVKNSWGPEWGWNGYVKMAKDQNNHCGIATAASYPTV 334
>sp|P25782|CYSP2_HOMAM Digestive cysteine proteinase 2 precursor
Length = 323
Score = 263 bits (672), Expect = 4e-70
Identities = 124/228 (54%), Positives = 160/228 (70%), Gaps = 1/228 (0%)
Frame = +2
Query: 41 STYMAPENIGVLPASVDWRQKGYVTPVKNQQQCGSCWSFSATGSLEGQYFRKNNRLISFS 220
S + + G VDWR KG VTPVK+Q QCGSCW+FS TGSLEGQ+F K LIS +
Sbjct: 96 SVFYPKKETGPQATEVDWRTKGAVTPVKDQGQCGSCWAFSTTGSLEGQHFLKTGSLISLA 155
Query: 221 EQQLVDCSXXXXXXXXXXXLMDNAFRYIK-DQGIESEGDYPYTATDGTCKRNPSKIVTKC 397
EQQLVDCS M++AF YIK + GI++E YPY A DG+C+ + + + C
Sbjct: 156 EQQLVDCSRPYGPQGCNGGWMNDAFDYIKANNGIDTEAAYPYEARDGSCRFDSNSVAATC 215
Query: 398 TGFTDIQSQNETDLANAVATVGPVSVAIDAGHASFQLYKSGIYNEESCSTTQLDHGVLAV 577
+G T+I S +ET L AV +GP+SV IDA H+SFQ Y SG+Y E SCS + LDH VLAV
Sbjct: 216 SGHTNIASGSETGLQQAVRDIGPISVTIDAAHSSFQFYSSGVYYEPSCSPSYLDHAVLAV 275
Query: 578 GYGTQIGKKYWIVKNSWDVTWGESGYIKMSKDKKNQCGIATMASYPLV 721
GYG++ G+ +W+VKNSW +WG++GYIKMS+++ N CGIAT+ASYPLV
Sbjct: 276 GYGSEGGQDFWLVKNSWATSWGDAGYIKMSRNRNNNCGIATVASYPLV 323
>sp|P25784|CYSP3_HOMAM Digestive cysteine proteinase 3 precursor
Length = 321
Score = 258 bits (660), Expect = 1e-68
Identities = 125/219 (57%), Positives = 156/219 (71%), Gaps = 1/219 (0%)
Frame = +2
Query: 68 GVLPASVDWRQKGYVTPVKNQQQCGSCWSFSATGSLEGQYFRKNNRLISFSEQQLVDCSX 247
G + A VDWR K VTPVK+Q+QCGSCW+FSATG+LEGQ+F KN+ L+S SEQQLVDCS
Sbjct: 104 GPMAADVDWRTKALVTPVKDQEQCGSCWAFSATGALEGQHFLKNDELVSLSEQQLVDCST 163
Query: 248 XXXXXXXXXXLMDNAFRYIKDQG-IESEGDYPYTATDGTCKRNPSKIVTKCTGFTDIQSQ 424
M +AF YIKD G I++E YPY A D +C+ + + I CTG ++Q
Sbjct: 164 DYGNDGCGGGWMTSAFDYIKDNGGIDTESSYPYEAEDRSCRFDANSIGAICTGSVEVQHT 223
Query: 425 NETDLANAVATVGPVSVAIDAGHASFQLYKSGIYNEESCSTTQLDHGVLAVGYGTQIGKK 604
E L AV+ VGP+SVAIDA H SFQ Y SG+Y E++CS T LDHGVLAVGYGT+ K
Sbjct: 224 EEA-LQEAVSGVGPISVAIDASHFSFQFYSSGVYYEQNCSPTFLDHGVLAVGYGTESTKD 282
Query: 605 YWIVKNSWDVTWGESGYIKMSKDKKNQCGIATMASYPLV 721
YW+VKNSW +WG++GYIKMS+++ N CGIA+ SYP V
Sbjct: 283 YWLVKNSWGSSWGDAGYIKMSRNRDNNCGIASEPSYPTV 321
>sp|Q28944|CATL_PIG Cathepsin L precursor [Contains: Cathepsin L heavy chain; Cathepsin
L light chain]
Length = 334
Score = 258 bits (659), Expect = 1e-68
Identities = 129/222 (58%), Positives = 153/222 (68%), Gaps = 6/222 (2%)
Frame = +2
Query: 74 LPASVDWRQKGYVTPVKNQQQCGSCWSFSATGSLEGQYFRKNNRLISFSEQQLVDCSXXX 253
+P SVDWR+KGYVT VKNQ QCGSCW+FSATG+LEGQ FRK +L+S SEQ LVDCS
Sbjct: 114 VPKSVDWREKGYVTAVKNQGQCGSCWAFSATGALEGQMFRKTGKLVSLSEQNLVDCSRPQ 173
Query: 254 XXXXXXXXLMDNAFRYIKDQ-GIESEGDYPYTATD-GTCKRNPSKIVTKCTGFTDIQSQN 427
LMDNAF+Y+KD G+++E YPY + +C P TGF DI Q
Sbjct: 174 GNQGCNGGLMDNAFQYVKDNGGLDTEESYPYLGRETNSCTYKPECSAANDTGFVDI-PQR 232
Query: 428 ETDLANAVATVGPVSVAIDAGHASFQLYKSGIYNEESCSTTQLDHGVLAVGYGTQ----I 595
E L AVATVGP+SVAIDAGH+SFQ YKSGIY + CS+ LDHGVL VGYG +
Sbjct: 233 EKALMKAVATVGPISVAIDAGHSSFQFYKSGIYYDPDCSSKDLDHGVLVVGYGFEGTDSN 292
Query: 596 GKKYWIVKNSWDVTWGESGYIKMSKDKKNQCGIATMASYPLV 721
K+WIVKNSW WG +GY+KM+KD+ N CGI+T ASYP V
Sbjct: 293 SSKFWIVKNSWGPEWGWNGYVKMAKDQNNHCGISTAASYPTV 334
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 88,631,499
Number of Sequences: 369166
Number of extensions: 1738231
Number of successful extensions: 5378
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 4737
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 4898
length of database: 68,354,980
effective HSP length: 108
effective length of database: 48,403,600
effective search space used: 7454154400
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)