Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_027_C16
(734 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P16237|HMDH_SCHMA 3-hydroxy-3-methylglutaryl-coenzyme A ... 122 1e-27
sp|O76819|HMDH_AGRIP 3-hydroxy-3-methylglutaryl-coenzyme A ... 105 1e-22
sp|P14773|HMDH_DROME 3-hydroxy-3-methylglutaryl-coenzyme A ... 102 8e-22
sp|Q29512|HMDH_RABIT 3-hydroxy-3-methylglutaryl-coenzyme A ... 100 5e-21
sp|P04035|HMDH_HUMAN 3-hydroxy-3-methylglutaryl-coenzyme A ... 100 5e-21
sp|Q01237|HMDH_MOUSE 3-hydroxy-3-methylglutaryl-coenzyme A ... 99 1e-20
sp|P54960|HMDH_BLAGE 3-hydroxy-3-methylglutaryl-coenzyme A ... 99 1e-20
sp|P00347|HMDH_CRIGR 3-hydroxy-3-methylglutaryl-coenzyme A ... 99 1e-20
sp|P09610|HMDH_MESAU 3-hydroxy-3-methylglutaryl-coenzyme A ... 99 1e-20
sp|P51639|HMDH_RAT 3-hydroxy-3-methylglutaryl-coenzyme A re... 99 1e-20
>sp|P16237|HMDH_SCHMA 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA reductase)
Length = 948
Score = 122 bits (305), Expect = 1e-27
Identities = 59/110 (53%), Positives = 84/110 (76%)
Frame = +2
Query: 83 TGQDLAQVVESSSCITEMEALPQKNNTNKFDLLITCTMPCLEVGVIGGGTKLKAQKSCLS 262
TGQDLAQVV+SSSC+T++E + + L+ + TMPCLEVG +GGGT+L Q++CL
Sbjct: 774 TGQDLAQVVDSSSCLTQLEV-----DLSDDSLVASVTMPCLEVGTVGGGTRLSGQRACLD 828
Query: 263 LLNLNEEKPCENFARIICATVLCSELNLMAALQTNDLVKSHLRLNRAQNN 412
LL+L+ ++P E+ +RII TVL +EL+LMAAL T+DLVK+H+ NRA+ +
Sbjct: 829 LLDLSVDRPTEHLSRIIAGTVLAAELSLMAALDTDDLVKAHMHFNRAKQS 878
>sp|O76819|HMDH_AGRIP 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA reductase)
Length = 833
Score = 105 bits (263), Expect = 1e-22
Identities = 62/115 (53%), Positives = 75/115 (65%), Gaps = 5/115 (4%)
Frame = +2
Query: 83 TGQDLAQVVESSSCITEMEALPQKNNTNKFDLLITCTMPCLEVGVIGGGTKLKAQKSCLS 262
TGQD AQ V SS+C T ME + N DL +TCTMP LEVG +GGGT L Q +CL
Sbjct: 708 TGQDPAQNVTSSNCSTNMEVCGE----NGEDLYVTCTMPSLEVGTVGGGTILTGQGACLD 763
Query: 263 LLNLNEE--KPCENFARI---ICATVLCSELNLMAALQTNDLVKSHLRLNRAQNN 412
+L + +P EN AR+ ICATVL EL+LMAAL +DLVKSH+R NR+ N
Sbjct: 764 ILGVKGAGARPAENSARLASLICATVLAGELSLMAALVNSDLVKSHMRHNRSTVN 818
>sp|P14773|HMDH_DROME 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA reductase)
Length = 920
Score = 102 bits (255), Expect = 8e-22
Identities = 58/113 (51%), Positives = 75/113 (66%), Gaps = 6/113 (5%)
Frame = +2
Query: 83 TGQDLAQVVESSSCITEMEALPQKNNTNKFDLLITCTMPCLEVGVIGGGTKLKAQKSCLS 262
TGQD AQ V SS+C T ME + N DL +TCTMP LEVG +GGGT L Q +CL
Sbjct: 790 TGQDPAQNVTSSNCSTAMECWAE----NSEDLYMTCTMPSLEVGTVGGGTGLPGQSACLE 845
Query: 263 LLNL---NEEKPCEN---FARIICATVLCSELNLMAALQTNDLVKSHLRLNRA 403
+L + + +P +N A+I+CATV+ EL+LMAAL +DLVKSH+R NR+
Sbjct: 846 MLGVRGAHATRPGDNAKKLAQIVCATVMAGELSLMAALVNSDLVKSHMRHNRS 898
>sp|Q29512|HMDH_RABIT 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA reductase)
Length = 888
Score = 100 bits (248), Expect = 5e-21
Identities = 57/115 (49%), Positives = 74/115 (64%), Gaps = 6/115 (5%)
Frame = +2
Query: 86 GQDLAQVVESSSCITEMEALPQKNNTNKFDLLITCTMPCLEVGVIGGGTKLKAQKSCLSL 265
GQD AQ V SS+CIT MEA N DL I+CTMP +E+G +GGGT L Q++CL +
Sbjct: 765 GQDAAQNVGSSNCITLMEASGPPNE----DLYISCTMPSIEIGTVGGGTNLLPQQACLQM 820
Query: 266 LNLN---EEKPCEN---FARIICATVLCSELNLMAALQTNDLVKSHLRLNRAQNN 412
L + ++ P EN ARI+C TV+ EL+LMAAL LVKSH+ NR++ N
Sbjct: 821 LGVQGACKDSPGENARQLARIVCGTVMAGELSLMAALAAGHLVKSHMIHNRSKIN 875
>sp|P04035|HMDH_HUMAN 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA reductase)
Length = 888
Score = 100 bits (248), Expect = 5e-21
Identities = 57/115 (49%), Positives = 74/115 (64%), Gaps = 6/115 (5%)
Frame = +2
Query: 86 GQDLAQVVESSSCITEMEALPQKNNTNKFDLLITCTMPCLEVGVIGGGTKLKAQKSCLSL 265
GQD AQ V SS+CIT MEA N DL I+CTMP +E+G +GGGT L Q++CL +
Sbjct: 765 GQDAAQNVGSSNCITLMEASGPTNE----DLYISCTMPSIEIGTVGGGTNLLPQQACLQM 820
Query: 266 LNLN---EEKPCEN---FARIICATVLCSELNLMAALQTNDLVKSHLRLNRAQNN 412
L + ++ P EN ARI+C TV+ EL+LMAAL LVKSH+ NR++ N
Sbjct: 821 LGVQGACKDNPGENARQLARIVCGTVMAGELSLMAALAAGHLVKSHMIHNRSKIN 875
>sp|Q01237|HMDH_MOUSE 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA reductase)
Length = 887
Score = 99.0 bits (245), Expect = 1e-20
Identities = 56/115 (48%), Positives = 74/115 (64%), Gaps = 6/115 (5%)
Frame = +2
Query: 86 GQDLAQVVESSSCITEMEALPQKNNTNKFDLLITCTMPCLEVGVIGGGTKLKAQKSCLSL 265
GQD AQ V SS+CIT MEA N DL I+CTMP +E+G +GGGT L Q++CL +
Sbjct: 764 GQDAAQNVGSSNCITLMEASGPTNE----DLYISCTMPSIEIGTVGGGTNLLPQQACLQM 819
Query: 266 LNLN---EEKPCEN---FARIICATVLCSELNLMAALQTNDLVKSHLRLNRAQNN 412
L + ++ P EN ARI+C TV+ EL+LMAAL LV+SH+ NR++ N
Sbjct: 820 LGVQGACKDNPGENARQLARIVCGTVMAGELSLMAALAAGHLVRSHMVHNRSKIN 874
>sp|P54960|HMDH_BLAGE 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA reductase)
Length = 856
Score = 99.0 bits (245), Expect = 1e-20
Identities = 63/136 (46%), Positives = 78/136 (57%), Gaps = 6/136 (4%)
Frame = +2
Query: 14 VAGSASGGXXXXXXXXXXXXXXXTGQDLAQVVESSSCITEMEALPQKNNTNKFDLLITCT 193
VAGS GG TGQD AQ V SS+C+T ME + DL ++CT
Sbjct: 710 VAGSI-GGFNAHAANIVTAIFIATGQDPAQNVGSSNCMTLMEPWGEDGK----DLYVSCT 764
Query: 194 MPCLEVGVIGGGTKLKAQKSCLSLLNL---NEEKPCEN---FARIICATVLCSELNLMAA 355
MP +E+G IGGGT L Q +CL +L + NE P EN ARI+C TVL EL+LM+A
Sbjct: 765 MPSIEIGTIGGGTVLPPQAACLDMLGVRGANEMCPGENANTLARIVCGTVLAGELSLMSA 824
Query: 356 LQTNDLVKSHLRLNRA 403
L LVKSH+R NR+
Sbjct: 825 LAAGHLVKSHMRHNRS 840
>sp|P00347|HMDH_CRIGR 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA reductase)
Length = 887
Score = 99.0 bits (245), Expect = 1e-20
Identities = 56/115 (48%), Positives = 74/115 (64%), Gaps = 6/115 (5%)
Frame = +2
Query: 86 GQDLAQVVESSSCITEMEALPQKNNTNKFDLLITCTMPCLEVGVIGGGTKLKAQKSCLSL 265
GQD AQ V SS+CIT MEA N DL I+CTMP +E+G +GGGT L Q++CL +
Sbjct: 764 GQDAAQNVGSSNCITLMEASGPTNE----DLYISCTMPSIEIGTVGGGTNLLPQQACLQM 819
Query: 266 LNLN---EEKPCEN---FARIICATVLCSELNLMAALQTNDLVKSHLRLNRAQNN 412
L + ++ P EN ARI+C TV+ EL+LMAAL LV+SH+ NR++ N
Sbjct: 820 LGVQGACKDNPGENARQLARIVCGTVMAGELSLMAALAAGHLVRSHMVHNRSKIN 874
>sp|P09610|HMDH_MESAU 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA reductase)
Length = 887
Score = 99.0 bits (245), Expect = 1e-20
Identities = 56/115 (48%), Positives = 74/115 (64%), Gaps = 6/115 (5%)
Frame = +2
Query: 86 GQDLAQVVESSSCITEMEALPQKNNTNKFDLLITCTMPCLEVGVIGGGTKLKAQKSCLSL 265
GQD AQ V SS+CIT MEA N DL I+CTMP +E+G +GGGT L Q++CL +
Sbjct: 764 GQDAAQNVGSSNCITLMEASGPTNE----DLYISCTMPSIEIGTVGGGTNLLPQQACLQM 819
Query: 266 LNLN---EEKPCEN---FARIICATVLCSELNLMAALQTNDLVKSHLRLNRAQNN 412
L + ++ P EN ARI+C TV+ EL+LMAAL LV+SH+ NR++ N
Sbjct: 820 LGVQGACKDNPGENARQLARIVCGTVMAGELSLMAALAAGHLVRSHMVHNRSKIN 874
>sp|P51639|HMDH_RAT 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA reductase)
Length = 887
Score = 99.0 bits (245), Expect = 1e-20
Identities = 56/115 (48%), Positives = 74/115 (64%), Gaps = 6/115 (5%)
Frame = +2
Query: 86 GQDLAQVVESSSCITEMEALPQKNNTNKFDLLITCTMPCLEVGVIGGGTKLKAQKSCLSL 265
GQD AQ V SS+CIT MEA N DL I+CTMP +E+G +GGGT L Q++CL +
Sbjct: 764 GQDAAQNVGSSNCITLMEASGPTNE----DLYISCTMPSIEIGTVGGGTNLLPQQACLQM 819
Query: 266 LNLN---EEKPCEN---FARIICATVLCSELNLMAALQTNDLVKSHLRLNRAQNN 412
L + ++ P EN ARI+C TV+ EL+LMAAL LV+SH+ NR++ N
Sbjct: 820 LGVQGACKDNPGENARQLARIVCGTVMAGELSLMAALAAGHLVRSHMVHNRSKIN 874
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 69,399,103
Number of Sequences: 369166
Number of extensions: 1215535
Number of successful extensions: 2374
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 2255
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 2287
length of database: 68,354,980
effective HSP length: 108
effective length of database: 48,403,600
effective search space used: 6582889600
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)