Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_027_C09
(849 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q9NX52|RHBD2_HUMAN Rhomboid-related protein 2 (RRP2) (Rh... 192 8e-49
sp|P58872|RHBD4_HUMAN Rhomboid-related protein 4 (Ventrhoid... 167 4e-41
sp|P58873|RHBD4_MOUSE Rhomboid-related protein 4 (Ventrhoid... 164 2e-40
sp|Q19821|ROM1_CAEEL Rhomboid related protein 1 163 6e-40
sp|P20350|RHOM_DROME Rhomboid protein (Veinlet protein) 159 1e-38
sp|Q8VC82|RHBD1_MOUSE Rhomboid-related protein 1 (RRP) (Rho... 158 2e-38
sp|O75783|RHB1_HUMAN Rhomboid-related protein 1 (RRP) (Rhom... 158 2e-38
sp|P34356|ROM2_CAEEL Rhomboid related protein 2 144 4e-34
sp|O88779|RHBD1_RAT Rhomboid-related protein 1 (RRP) (Rhomb... 107 4e-23
sp|P54493|YQGP_BACSU Hypothetical protein yqgP 49 2e-05
>sp|Q9NX52|RHBD2_HUMAN Rhomboid-related protein 2 (RRP2) (Rhomboid-like protein 2)
Length = 303
Score = 192 bits (489), Expect = 8e-49
Identities = 107/257 (41%), Positives = 151/257 (58%), Gaps = 1/257 (0%)
Frame = +2
Query: 2 YSEAYDCKPPPFIIPLITLSQIGVFIYYAIKLNTDTDKTNDVTARSGVHLRSPLIYSPYR 181
Y E +C PPP I I+L+++ VFIYYA+ + +T +G+ L SP IYSP +
Sbjct: 62 YLERANCFPPPVFIISISLAELAVFIYYAVW----KPQKQWITLDTGI-LESPFIYSPEK 116
Query: 182 RIQAWRFIGYMFLHQGYIHLIFNCLMQLVLGTLLEVVHKFWRVGIVYILGVLAGSLAHSC 361
R +AWRFI YM +H G H++ N MQLVLG LE+VHK RVG+VY+ GV+AGSLA S
Sbjct: 117 REEAWRFISYMLVHAGVQHILGNLCMQLVLGIPLEMVHKGLRVGLVYLAGVIAGSLASSI 176
Query: 362 FDATKYLVGASGGCYALIGAHFATIITNWDTMQKKWLENPINFLSSAVFRLIVLFLLAGG 541
FD +YLVGASGG YAL+G +F ++ N+ M + +FRL+++ L+
Sbjct: 177 FDPLRYLVGASGGVYALMGGYFMNVLVNFQEM----------IPAFGIFRLLIIILIIVL 226
Query: 542 DTGIAIYDR-FAKEVPTPIGFSAHFGGALAGFLIGIPVLRNLEVKKWEKICFWISLALYC 718
D G A+Y R F E +P+ F+AH G AG IG V + + FWI++A Y
Sbjct: 227 DMGFALYRRFFVPEDGSPVSFAAHIAGGFAGMSIGYTVFSCFDKALLKDPRFWIAIAAYL 286
Query: 719 LFMIGAIVFNVICASKN 769
++ A+ FN+ + N
Sbjct: 287 ACVLFAVFFNIFLSPAN 303
>sp|P58872|RHBD4_HUMAN Rhomboid-related protein 4 (Ventrhoid transmembrane protein)
Length = 404
Score = 167 bits (422), Expect = 4e-41
Identities = 88/253 (34%), Positives = 142/253 (56%), Gaps = 3/253 (1%)
Frame = +2
Query: 2 YSEAYDCKPPPFIIPLITLSQIGVFIYYAIKLNTDTDKTNDVTARSGVHLRSPLIYSPYR 181
Y ++Y C PPP+ + +TL ++ F+Y + L + +L++ L+Y P
Sbjct: 153 YYDSYTCCPPPWFMITVTLLEVAFFLYNGVSLGQFVLQVTHPR-----YLKNSLVYHPQL 207
Query: 182 RIQAWRFIGYMFLHQGYIHLIFNCLMQLVLGTLLEVVHKFWRVGIVYILGVLAGSLAHSC 361
R Q WR++ Y+F+H G HL N ++QL++G LE+VH R+G+VY+ GV+AGSLA S
Sbjct: 208 RAQVWRYLTYIFMHAGIEHLGLNVVLQLLVGVPLEMVHGATRIGLVYVAGVVAGSLAVSV 267
Query: 362 FDATKYLVGASGGCYALIGAHFATIITNWDTMQKKWLENPINFLSSAVFRLIVLFLLAGG 541
D T +VG+SGG YAL+ AH A I+ NW M+ ++ + R+ V +
Sbjct: 268 ADMTAPVVGSSGGVYALVSAHLANIVMNWSGMKCQF----------KLLRMAVALICMSM 317
Query: 542 DTGIAIYDRFAKEVPTPI---GFSAHFGGALAGFLIGIPVLRNLEVKKWEKICFWISLAL 712
+ G A++ RF P F AH GG G +G+ VLRN E + ++ +WI +A+
Sbjct: 318 EFGRAVWLRFHPSAYPPCPHPSFVAHLGGVAVGITLGVVVLRNYEQRLQDQSLWWIFVAM 377
Query: 713 YCLFMIGAIVFNV 751
Y +F++ A+ +N+
Sbjct: 378 YTVFVLFAVFWNI 390
>sp|P58873|RHBD4_MOUSE Rhomboid-related protein 4 (Ventrhoid transmembrane protein)
Length = 404
Score = 164 bits (416), Expect = 2e-40
Identities = 88/253 (34%), Positives = 142/253 (56%), Gaps = 3/253 (1%)
Frame = +2
Query: 2 YSEAYDCKPPPFIIPLITLSQIGVFIYYAIKLNTDTDKTNDVTARSGVHLRSPLIYSPYR 181
Y ++Y C PPP+ + ITL ++ +F+Y + L+ + +L++ L+Y P
Sbjct: 153 YYDSYTCCPPPWFMITITLLEVALFLYNGVLLDQFVLQVTHPR-----YLKNSLVYHPQL 207
Query: 182 RIQAWRFIGYMFLHQGYIHLIFNCLMQLVLGTLLEVVHKFWRVGIVYILGVLAGSLAHSC 361
R QAWR++ Y+F+H G L N +QL++G LE+VH R+G+VY+ GV+AGSLA S
Sbjct: 208 RAQAWRYVTYIFMHAGVEQLGLNVALQLLVGVPLEMVHGATRIGLVYVAGVVAGSLAVSV 267
Query: 362 FDATKYLVGASGGCYALIGAHFATIITNWDTMQKKWLENPINFLSSAVFRLIVLFLLAGG 541
D T +VG+SGG YAL+ AH A I+ NW M+ ++ + R+ V +
Sbjct: 268 ADMTAPVVGSSGGVYALVSAHLANIVMNWSGMKCQF----------KLLRMAVALICMSM 317
Query: 542 DTGIAIYDRFAKEVPTPI---GFSAHFGGALAGFLIGIPVLRNLEVKKWEKICFWISLAL 712
+ G A++ RF P F AH GG G +G+ VLRN E + ++ +WI + +
Sbjct: 318 EFGRAVWLRFHPSAYPPCPHPSFVAHLGGVAVGITLGVVVLRNYEQRLQDQSLWWIFVTM 377
Query: 713 YCLFMIGAIVFNV 751
Y +F++ A+ +N+
Sbjct: 378 YTIFVLFAVFWNI 390
>sp|Q19821|ROM1_CAEEL Rhomboid related protein 1
Length = 356
Score = 163 bits (412), Expect = 6e-40
Identities = 100/266 (37%), Positives = 138/266 (51%), Gaps = 9/266 (3%)
Frame = +2
Query: 2 YSEAYDCKPPPFIIPLITLSQIGVFIYYAIKLNTDTDKTNDV---TARSGVHLRSP---- 160
Y ++Y PPP + LIT+ Q+G+F +Y ++D + A VH
Sbjct: 101 YIDSYSWCPPPIFMLLITIIQVGIFFFY-----WESDGGRSIWTDCAGCFVHHNHTAPGI 155
Query: 161 LIYSPYRRIQAWRFIGYMFLHQGYIHLIFNCLMQLVLGTLLEVVHKFWRVGIVYILGVLA 340
I++P R +AWRF YMFLH G HL+ N ++QL++G LEV HK WR+G +Y+L V +
Sbjct: 156 FIFAPKLRGEAWRFTSYMFLHAGLNHLLGNVIIQLLVGIPLEVAHKIWRIGPIYLLAVTS 215
Query: 341 GSLAHSCFDATKYLVGASGGCYALIGAHFATIITNWDTMQKKWLENPINFLSSAVFRLIV 520
GSL D LVGAS G YALI AH A +I NW M +W+ R++V
Sbjct: 216 GSLLQYAIDPNSLLVGASAGVYALIFAHVANVILNWHEMPLRWI------------RVLV 263
Query: 521 LFLLAGGDTGIAIYDRFAKEVPTPIGFSAHFGGALAGFLIGIPVLRNLEVKKWEKICFWI 700
LF+ D G AI+ RF + AH GA+ G G VL N+ + EKI ++
Sbjct: 264 LFVFIFLDFGGAIHRRFYTNDCDSVSHLAHIAGAVTGLFFGYVVLYNVVEHRIEKIIRYV 323
Query: 701 SLALYCLFMIGAIVFNVICA--SKNL 772
L LY F I+F ++ SKNL
Sbjct: 324 CLFLYSAFFATTIIFVIVRQPYSKNL 349
>sp|P20350|RHOM_DROME Rhomboid protein (Veinlet protein)
Length = 355
Score = 159 bits (401), Expect = 1e-38
Identities = 93/249 (37%), Positives = 137/249 (55%), Gaps = 8/249 (3%)
Frame = +2
Query: 32 PFIIPLITLSQIGVFIYYAIKLNTDTDKTNDVTARSGVHLRSP----LIYSPYRRIQAWR 199
P+ I +I++ +I +F Y D+ G+ + P L+Y P RR+Q WR
Sbjct: 102 PWFILVISIIEIAIFAY---------DRYTMPAQNFGLPVPIPSDSVLVYRPDRRLQVWR 152
Query: 200 FIGYMFLHQGYIHLIFNCLMQLVLGTLLEVVHKFWRVGIVYILGVLAGSLAHSCFDATKY 379
F YMFLH + HL FN ++QL G LEV+H R+G++Y+ GV AGSL S D+ +
Sbjct: 153 FFSYMFLHANWFHLGFNIVIQLFFGIPLEVMHGTARIGVIYMAGVFAGSLGTSVVDSEVF 212
Query: 380 LVGASGGCYALIGAHFATIITNWDTMQKKWLENPINFLSSAVFRLIVLFLLAGGDTGIAI 559
LVGASGG YAL+ AH A I N+ M+ SA +L + + D G A+
Sbjct: 213 LVGASGGVYALLAAHLANITLNYAHMK------------SASTQLGSVVIFVSCDLGYAL 260
Query: 560 YDRF----AKEVPTPIGFSAHFGGALAGFLIGIPVLRNLEVKKWEKICFWISLALYCLFM 727
Y ++ A + + AH GALAG IG VL+N +++E++ +W++L +YC F
Sbjct: 261 YTQYFDGSAFAKGPQVSYIAHLTGALAGLTIGFLVLKNFGHREYEQLIWWLALGVYCAFT 320
Query: 728 IGAIVFNVI 754
+ AIVFN+I
Sbjct: 321 VFAIVFNLI 329
>sp|Q8VC82|RHBD1_MOUSE Rhomboid-related protein 1 (RRP) (Rhomboid-like protein 1)
Length = 373
Score = 158 bits (400), Expect = 2e-38
Identities = 88/245 (35%), Positives = 137/245 (55%), Gaps = 3/245 (1%)
Frame = +2
Query: 26 PPPFIIPLITLSQIGVFIYYAIKLNTDTDKTNDVTARSGVHLRSPLIYSPYRRIQAWRFI 205
PPP + +TL+QI VF+ Y +LN +T +++SPL+Y P R +AWRF+
Sbjct: 130 PPPVFMASVTLAQIIVFLCYGARLNKWVLQTYHPE-----YMKSPLVYHPGHRARAWRFL 184
Query: 206 GYMFLHQGYIHLIFNCLMQLVLGTLLEVVHKFWRVGIVYILGVLAGSLAHSCFDATKYLV 385
YMF+H G L FN L+QL++G LE+VH R+ ++Y+ GVLAGSL S D +V
Sbjct: 185 TYMFMHVGLEQLGFNALLQLMIGVPLEMVHGVLRISLLYLAGVLAGSLTVSITDMRAPVV 244
Query: 386 GASGGCYALIGAHFATIITNWDTMQKKWLENPINFLSSAVFRLIVLFLLAGGDTGIAIYD 565
G SGG YAL AH A ++ NW M+ + + R+++ + + G A++
Sbjct: 245 GGSGGVYALCSAHLANVVMNWAGMRCPY----------KLLRMVLALVCMSSEVGRAVWL 294
Query: 566 RFAKEVPT---PIGFSAHFGGALAGFLIGIPVLRNLEVKKWEKICFWISLALYCLFMIGA 736
RF+ +P F AH GA+ G +G+ +LR+ E + ++ +W+ L Y F++ A
Sbjct: 295 RFSPPLPASGPQPSFMAHLAGAVVGVSMGLTILRSYEERLRDQCGWWVVLLAYGTFLLFA 354
Query: 737 IVFNV 751
I +NV
Sbjct: 355 IFWNV 359
>sp|O75783|RHB1_HUMAN Rhomboid-related protein 1 (RRP) (Rhomboid-like protein 1)
Length = 438
Score = 158 bits (400), Expect = 2e-38
Identities = 87/245 (35%), Positives = 137/245 (55%), Gaps = 3/245 (1%)
Frame = +2
Query: 26 PPPFIIPLITLSQIGVFIYYAIKLNTDTDKTNDVTARSGVHLRSPLIYSPYRRIQAWRFI 205
PPP + +TL+QI VF+ Y +LN +T +++SPL+Y P R +AWRF+
Sbjct: 195 PPPVFMASVTLAQIIVFLCYGARLNKWVLQTYHPE-----YMKSPLVYHPGHRARAWRFL 249
Query: 206 GYMFLHQGYIHLIFNCLMQLVLGTLLEVVHKFWRVGIVYILGVLAGSLAHSCFDATKYLV 385
YMF+H G L FN L+QL++G LE+VH R+ ++Y+ GVLAGSL S D +V
Sbjct: 250 TYMFMHVGLEQLGFNALLQLMIGVPLEMVHGLLRISLLYLAGVLAGSLTVSITDMRAPVV 309
Query: 386 GASGGCYALIGAHFATIITNWDTMQKKWLENPINFLSSAVFRLIVLFLLAGGDTGIAIYD 565
G SGG YAL AH A ++ NW M+ + + R+++ + + G A++
Sbjct: 310 GGSGGVYALCSAHLANVVMNWAGMRCPY----------KLLRMVLALVCMSSEVGRAVWL 359
Query: 566 RFAKEVPT---PIGFSAHFGGALAGFLIGIPVLRNLEVKKWEKICFWISLALYCLFMIGA 736
RF+ +P F AH GA+ G +G+ +LR+ E + ++ +W+ L Y F++ A
Sbjct: 360 RFSPPLPASGPQPSFMAHLAGAVVGVSMGLTILRSYEERLRDQCGWWVVLLAYGTFLLFA 419
Query: 737 IVFNV 751
+ +NV
Sbjct: 420 VFWNV 424
>sp|P34356|ROM2_CAEEL Rhomboid related protein 2
Length = 435
Score = 144 bits (362), Expect = 4e-34
Identities = 81/253 (32%), Positives = 127/253 (50%)
Frame = +2
Query: 8 EAYDCKPPPFIIPLITLSQIGVFIYYAIKLNTDTDKTNDVTARSGVHLRSPLIYSPYRRI 187
+ Y C PPP + +++ Q+ ++YY + D + V + SPLI S Y
Sbjct: 114 QRYKCVPPPIFLIFLSIVQLAFYLYYVV------DSSEGVWLSGPIPTMSPLIVSQYHLP 167
Query: 188 QAWRFIGYMFLHQGYIHLIFNCLMQLVLGTLLEVVHKFWRVGIVYILGVLAGSLAHSCFD 367
+ WR Y ++ G H+IFN L+QL +G LE+VH+ WR+ I+Y +GVL GS+ D
Sbjct: 168 ELWRLFTYCLINVGIFHIIFNILIQLAIGVPLELVHR-WRIYILYFMGVLFGSILSLALD 226
Query: 368 ATKYLVGASGGCYALIGAHFATIITNWDTMQKKWLENPINFLSSAVFRLIVLFLLAGGDT 547
T +L G + G ++LI +H TI TN+ M+ +A RL +L + A D
Sbjct: 227 PTVFLCGGAAGSFSLIASHITTIATNFKEME------------NATCRLPILIVFAALDY 274
Query: 548 GIAIYDRFAKEVPTPIGFSAHFGGALAGFLIGIPVLRNLEVKKWEKICFWISLALYCLFM 727
+A+Y RF + H GG +AG L + R + ++ + FW+SL L F+
Sbjct: 275 VLAVYQRFFAPRIDKVSMYGHLGGLVAGILFTFILFRGSKPSRFYTVSFWVSLVLSGFFI 334
Query: 728 IGAIVFNVICASK 766
AI +I A +
Sbjct: 335 --AICITLIAAPR 345
>sp|O88779|RHBD1_RAT Rhomboid-related protein 1 (RRP) (Rhomboid-like protein 1)
Length = 164
Score = 107 bits (267), Expect = 4e-23
Identities = 59/174 (33%), Positives = 94/174 (54%), Gaps = 3/174 (1%)
Frame = +2
Query: 215 FLHQGYIHLIFNCLMQLVLGTLLEVVHKFWRVGIVYILGVLAGSLAHSCFDATKYLVGAS 394
F+H G L FN L+QL++G LE+VH R+ ++Y+ GVLAGSL S D +VG S
Sbjct: 1 FMHVGLEQLGFNALLQLMIGVPLEMVHGVLRISLLYLAGVLAGSLTVSITDMRAPVVGGS 60
Query: 395 GGCYALIGAHFATIITNWDTMQKKWLENPINFLSSAVFRLIVLFLLAGGDTGIAIYDRFA 574
GG YAL AH A ++ NW M+ + + R+++ + + G A++ RF+
Sbjct: 61 GGVYALCSAHLANVVMNWAGMRCPY----------KLLRMVLALVCMSSEVGRAVWLRFS 110
Query: 575 KEVPT---PIGFSAHFGGALAGFLIGIPVLRNLEVKKWEKICFWISLALYCLFM 727
+P F AH GA+ G +G+ +LR+ E + ++ +W+ L Y F+
Sbjct: 111 PPLPASGPQPSFMAHLAGAVVGVSMGLTILRSYEERLRDQCGWWVVLLAYGTFL 164
>sp|P54493|YQGP_BACSU Hypothetical protein yqgP
Length = 507
Score = 48.5 bits (114), Expect = 2e-05
Identities = 42/156 (26%), Positives = 67/156 (42%), Gaps = 4/156 (2%)
Frame = +2
Query: 194 WRFIGYMFLHQGYIHLIFNCLMQLVLGTLLEVVHKFWRVGIVYILGVLAGSLAHSCFDAT 373
WR + + LH G HL FN L +GT +E ++ R ++Y+ + GS+A F
Sbjct: 223 WRLLTPIVLHIGIAHLAFNTLALWSVGTAVERMYGSGRFLLIYLAAGITGSIASFVFSPY 282
Query: 374 KYLVGASGGCYALIGAHFATIITNWDTMQKKWLENPINFLSSAVFRLIVLFLLAGGDTGI 553
GASG + +GA ++N FL + +IV+ ++ G G
Sbjct: 283 P-SAGASGAIFGCLGALLYVALSNRKM-----------FLRTIGTNIIVIIIINLG-FGF 329
Query: 554 AIYDRFAKEVPTPIGFSAHFGGALAGFL----IGIP 649
A+ + I S H GG + GF +G+P
Sbjct: 330 AV---------SNIDNSGHIGGLIGGFFAAAALGLP 356
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 102,862,832
Number of Sequences: 369166
Number of extensions: 2223387
Number of successful extensions: 5890
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 5706
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 5868
length of database: 68,354,980
effective HSP length: 109
effective length of database: 48,218,865
effective search space used: 8341863645
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)