Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= Dr_sW_027_B06 (860 letters) Database: Non-redundant SwissProt sequences 184,735 sequences; 68,354,980 total letters Score E Sequences producing significant alignments: (bits) Value sp|Q24940|CATLP_FASHE Cathepsin L-like proteinase precursor 183 6e-46 sp|O60911|CATL2_HUMAN Cathepsin L2 precursor (Cathepsin V) ... 178 2e-44 sp|Q9R014|CATJ_MOUSE Cathepsin J precursor (Cathepsin P) (C... 172 8e-43 sp|Q9GL24|CATL_CANFA Cathepsin L precursor [Contains: Cathe... 167 3e-41 sp|Q9JIA9|CATR_MOUSE Cathepsin R precursor 167 3e-41 sp|Q28944|CATL_PIG Cathepsin L precursor [Contains: Catheps... 166 6e-41 sp|P07711|CATL_HUMAN Cathepsin L precursor (Major excreted ... 164 2e-40 sp|P06797|CATL_MOUSE Cathepsin L precursor (Major excreted ... 164 3e-40 sp|Q26636|CATL_SARPE Cathepsin L precursor [Contains: Cathe... 162 1e-39 sp|Q95029|CATL_DROME Cathepsin L precursor (Cysteine protei... 161 2e-39
>sp|Q24940|CATLP_FASHE Cathepsin L-like proteinase precursor Length = 326 Score = 183 bits (464), Expect = 6e-46 Identities = 100/272 (36%), Positives = 148/272 (54%), Gaps = 6/272 (2%) Frame = +3 Query: 63 WEDYKTIFNKKYSDETDLIRRNIWEENLKFIKQHNLQFDLGKTKFSVGLNEFSDMNQKEF 242 W +K ++NK+Y+ D RRNIWE+N+K I++HNL+ DLG +++GLN+F+DM +EF Sbjct: 21 WHQWKRMYNKEYNGADDQHRRNIWEKNVKHIQEHNLRHDLGLVTYTLGLNQFTDMTFEEF 80 Query: 243 QSNILSVXXXXXXXXXXXXXXXXXXLSRNDFITT------PNNIKLPDSWDWREKGAVSP 404 ++ L+ +SR I + NN +PD DWRE G V+ Sbjct: 81 KAKYLT------------------EMSRASDILSHGVPYEANNRAVPDKIDWRESGYVTE 122 Query: 405 VGNQRNNCCGYAFAAAGALEGQNFNLTKTLEILSKQQIIDCSIYYGNSNCYSGCILSKAY 584 V +Q N +AF+ G +EGQ +T S+QQ++DCS +GN+ C SG ++ AY Sbjct: 123 VKDQGNCGSCWAFSTTGTMEGQYMKNERTSISFSEQQLVDCSGPWGNNGC-SGGLMENAY 181 Query: 585 AYLADYGSELDEDYPFVGYNSNCKYDKSLATVKPYGFKYVSRGKEADLMNAVYNIGPISA 764 YL +G E + YP+ C+Y+K L K G+ V G E +L N V P + Sbjct: 182 QYLKQFGLETESSYPYTAVEGQCRYNKQLGVAKVTGYYTVHSGSEVELKNLVGARRPAAV 241 Query: 765 AIDASPNTFKQYKTGIYDDTSCSSNNVNHAVL 860 A+D + F Y++GIY +CS VNHAVL Sbjct: 242 AVDVE-SDFMMYRSGIYQSQTCSPLRVNHAVL 272
>sp|O60911|CATL2_HUMAN Cathepsin L2 precursor (Cathepsin V) (Cathepsin U) Length = 334 Score = 178 bits (452), Expect = 2e-44 Identities = 102/287 (35%), Positives = 152/287 (52%), Gaps = 1/287 (0%) Frame = +3 Query: 3 FMLNNASRIDSNVNSQLNKDWEDYKTIFNKKYSDETDLIRRNIWEENLKFIKQHNLQFDL 182 F L AS + + L+ W +K + Y + RR +WE+N+K I+ HN ++ Sbjct: 10 FCLGIASAVPK-FDQNLDTKWYQWKATHRRLYGANEEGWRRAVWEKNMKMIELHNGEYSQ 68 Query: 183 GKTKFSVGLNEFSDMNQKEFQSNILSVXXXXXXXXXXXXXXXXXXLSRNDFITTPNNIKL 362 GK F++ +N F DM +EF+ + + P + L Sbjct: 69 GKHGFTMAMNAFGDMTNEEFRQMM--------------GCFRNQKFRKGKVFREPLFLDL 114 Query: 363 PDSWDWREKGAVSPVGNQRNNCCGYAFAAAGALEGQNFNLTKTLEILSKQQIIDCSIYYG 542 P S DWR+KG V+PV NQ+ +AF+A GALEGQ F T L LS+Q ++DCS G Sbjct: 115 PKSVDWRKKGYVTPVKNQKQCGSCWAFSATGALEGQMFRKTGKLVSLSEQNLVDCSRPQG 174 Query: 543 NSNCYSGCILSKAYAYLADYGS-ELDEDYPFVGYNSNCKYDKSLATVKPYGFKYVSRGKE 719 N C +G +++A+ Y+ + G + +E YP+V + CKY + GF V+ GKE Sbjct: 175 NQGC-NGGFMARAFQYVKENGGLDSEESYPYVAVDEICKYRPENSVANDTGFTVVAPGKE 233 Query: 720 ADLMNAVYNIGPISAAIDASPNTFKQYKTGIYDDTSCSSNNVNHAVL 860 LM AV +GPIS A+DA ++F+ YK+GIY + CSS N++H VL Sbjct: 234 KALMKAVATVGPISVAMDAGHSSFQFYKSGIYFEPDCSSKNLDHGVL 280
>sp|Q9R014|CATJ_MOUSE Cathepsin J precursor (Cathepsin P) (Catlrp-p) Length = 333 Score = 172 bits (437), Expect = 8e-43 Identities = 106/276 (38%), Positives = 151/276 (54%), Gaps = 5/276 (1%) Frame = +3 Query: 48 QLNKDWEDYKTIFNKKYSDETDLIRRNIWEENLKFIKQHNLQFDLGKTKFSVGLNEFSDM 227 +L+ +W+D+KT + K YS E + +RR +WEEN++ IK HN + LGK F++ +N+F D Sbjct: 24 KLDAEWKDWKTKYAKSYSPE-EALRRAVWEENMRMIKLHNKENSLGKNNFTMKMNKFGDQ 82 Query: 228 NQKEFQSNILSVXXXXXXXXXXXXXXXXXXLSRNDFITTPN-----NIKLPDSWDWREKG 392 +EF+ +I ++ +T P+ +I LPD DWRE+G Sbjct: 83 TSEEFRKSIDNIPIPAA-------------------MTDPHAQNHVSIGLPDYKDWREEG 123 Query: 393 AVSPVGNQRNNCCGYAFAAAGALEGQNFNLTKTLEILSKQQIIDCSIYYGNSNCYSGCIL 572 V+PV NQ +AFAAAGA+EGQ F T L LS Q ++DCS GN C SG Sbjct: 124 YVTPVRNQGKCGSCWAFAAAGAIEGQMFWKTGNLTPLSVQNLLDCSKTVGNKGCQSGTAH 183 Query: 573 SKAYAYLADYGSELDEDYPFVGYNSNCKYDKSLATVKPYGFKYVSRGKEADLMNAVYNIG 752 L + G E + YP+ G + C+Y A+ + + E L AV +IG Sbjct: 184 QAFEYVLKNKGLEAEATYPYEGKDGPCRYRSENASANITDYVNLP-PNELYLWVAVASIG 242 Query: 753 PISAAIDASPNTFKQYKTGIYDDTSCSSNNVNHAVL 860 P+SAAIDAS ++F+ Y GIY + +CSS VNHAVL Sbjct: 243 PVSAAIDASHDSFRFYNGGIYYEPNCSSYFVNHAVL 278
>sp|Q9GL24|CATL_CANFA Cathepsin L precursor [Contains: Cathepsin L heavy chain; Cathepsin L light chain] Length = 333 Score = 167 bits (423), Expect = 3e-41 Identities = 97/275 (35%), Positives = 144/275 (52%), Gaps = 2/275 (0%) Frame = +3 Query: 42 NSQLNKDWEDYKTIFNKKYSDETDLIRRNIWEENLKFIKQHNLQFDLGKTKFSVGLNEFS 221 + LN W +K + Y + RR +WE+N+K I+ HN ++ GK F++ +N F Sbjct: 22 DQSLNAQWYQWKATHRRLYGMNEEGWRRAVWEKNMKMIELHNREYSQGKHGFTMAMNAFG 81 Query: 222 DMNQKEFQSNILSVXXXXXXXXXXXXXXXXXXLSRNDFITTPNNIKLPDSWDWREKGAVS 401 DM +EF+ + + P ++P S DWREKG V+ Sbjct: 82 DMTNEEFRQVMNGFQNQKH--------------KKGKMFQEPLFAEIPKSVDWREKGYVT 127 Query: 402 PVGNQRNNCCGYAFAAAGALEGQNFNLTKTLEILSKQQIIDCSIYYGNSNCYSGCILSKA 581 PV NQ +AF+A GALEGQ F T L LS+Q ++DCS GN C +G ++ A Sbjct: 128 PVKNQGQCGSCWAFSATGALEGQMFRKTGKLVSLSEQNLVDCSRAQGNEGC-NGGLMDNA 186 Query: 582 YAYLADYGS-ELDEDYPFVGYNS-NCKYDKSLATVKPYGFKYVSRGKEADLMNAVYNIGP 755 + Y+ D G + +E YP++G ++ C Y + GF + + +E LM AV +GP Sbjct: 187 FRYVKDNGGLDSEESYPYLGRDTETCNYKPECSAANDTGFVDLPQ-REKALMKAVATLGP 245 Query: 756 ISAAIDASPNTFKQYKTGIYDDTSCSSNNVNHAVL 860 IS AIDA +F+ YK+GIY D CSS +++H VL Sbjct: 246 ISVAIDAGHQSFQFYKSGIYFDPDCSSKDLDHGVL 280
>sp|Q9JIA9|CATR_MOUSE Cathepsin R precursor Length = 334 Score = 167 bits (423), Expect = 3e-41 Identities = 96/274 (35%), Positives = 144/274 (52%) Frame = +3 Query: 39 VNSQLNKDWEDYKTIFNKKYSDETDLIRRNIWEENLKFIKQHNLQFDLGKTKFSVGLNEF 218 ++S L+ +W+D+K +NK YS + + ++R +WEE LK IK HN + LGK F++ +NEF Sbjct: 21 LDSSLDAEWQDWKIKYNKSYSLKEEKLKRVVWEEKLKMIKLHNRENSLGKNGFTMKMNEF 80 Query: 219 SDMNQKEFQSNILSVXXXXXXXXXXXXXXXXXXLSRNDFITTPNNIKLPDSWDWREKGAV 398 D +EF+ ++ + + LP DWR+KG V Sbjct: 81 GDQTDEEFRKMMIEISVWTHREGKSIMKREAGSI-------------LPKFVDWRKKGYV 127 Query: 399 SPVGNQRNNCCGYAFAAAGALEGQNFNLTKTLEILSKQQIIDCSIYYGNSNCYSGCILSK 578 +PV Q + +AFA GA+E Q T L LS Q ++DCS GN+ C G + Sbjct: 128 TPVRRQGDCDACWAFAVTGAIEAQAIWQTGKLTPLSVQNLVDCSKPQGNNGCLGGDTYNA 187 Query: 579 AYAYLADYGSELDEDYPFVGYNSNCKYDKSLATVKPYGFKYVSRGKEADLMNAVYNIGPI 758 L + G E + YP+ G + C+Y+ + + GF + + ++ LM AV IGPI Sbjct: 188 FQYVLHNGGLESEATYPYEGKDGPCRYNPKNSKAEITGFVSLPQSEDI-LMAAVATIGPI 246 Query: 759 SAAIDASPNTFKQYKTGIYDDTSCSSNNVNHAVL 860 +A IDAS +FK YK GIY + +CSS+ V H VL Sbjct: 247 TAGIDASHESFKNYKGGIYHEPNCSSDTVTHGVL 280
>sp|Q28944|CATL_PIG Cathepsin L precursor [Contains: Cathepsin L heavy chain; Cathepsin L light chain] Length = 334 Score = 166 bits (421), Expect = 6e-41 Identities = 100/283 (35%), Positives = 149/283 (52%), Gaps = 2/283 (0%) Frame = +3 Query: 18 ASRIDSNVNSQLNKDWEDYKTIFNKKYSDETDLIRRNIWEENLKFIKQHNLQFDLGKTKF 197 A ++D N L+ DW +K + Y + RR +WE+N+K I+ HN ++ GK F Sbjct: 18 APKLDQN----LDADWYKWKATHGRLYGMNEEGWRRAVWEKNMKMIELHNQEYSQGKHGF 73 Query: 198 SVGLNEFSDMNQKEFQSNILSVXXXXXXXXXXXXXXXXXXLSRNDFITTPNNIKLPDSWD 377 S+ +N F DM +EF+ + + +++P S D Sbjct: 74 SMAMNAFGDMTNEEFRQVMNGFQNQKH--------------KKGKVFHESLVLEVPKSVD 119 Query: 378 WREKGAVSPVGNQRNNCCGYAFAAAGALEGQNFNLTKTLEILSKQQIIDCSIYYGNSNCY 557 WREKG V+ V NQ +AF+A GALEGQ F T L LS+Q ++DCS GN C Sbjct: 120 WREKGYVTAVKNQGQCGSCWAFSATGALEGQMFRKTGKLVSLSEQNLVDCSRPQGNQGC- 178 Query: 558 SGCILSKAYAYLADYGS-ELDEDYPFVGYNSN-CKYDKSLATVKPYGFKYVSRGKEADLM 731 +G ++ A+ Y+ D G + +E YP++G +N C Y + GF + + +E LM Sbjct: 179 NGGLMDNAFQYVKDNGGLDTEESYPYLGRETNSCTYKPECSAANDTGFVDIPQ-REKALM 237 Query: 732 NAVYNIGPISAAIDASPNTFKQYKTGIYDDTSCSSNNVNHAVL 860 AV +GPIS AIDA ++F+ YK+GIY D CSS +++H VL Sbjct: 238 KAVATVGPISVAIDAGHSSFQFYKSGIYYDPDCSSKDLDHGVL 280
>sp|P07711|CATL_HUMAN Cathepsin L precursor (Major excreted protein) (MEP) [Contains: Cathepsin L heavy chain; Cathepsin L light chain] Length = 333 Score = 164 bits (416), Expect = 2e-40 Identities = 96/271 (35%), Positives = 141/271 (52%), Gaps = 1/271 (0%) Frame = +3 Query: 51 LNKDWEDYKTIFNKKYSDETDLIRRNIWEENLKFIKQHNLQFDLGKTKFSVGLNEFSDMN 230 L W +K + N+ Y + RR +WE+N+K I+ HN ++ GK F++ +N F DM Sbjct: 25 LEAQWTKWKAMHNRLYGMNEEGWRRAVWEKNMKMIELHNQEYREGKHSFTMAMNAFGDMT 84 Query: 231 QKEFQSNILSVXXXXXXXXXXXXXXXXXXLSRNDFITTPNNIKLPDSWDWREKGAVSPVG 410 +EF+ + + P + P S DWREKG V+PV Sbjct: 85 SEEFRQVMNGFQNRKPR--------------KGKVFQEPLFYEAPRSVDWREKGYVTPVK 130 Query: 411 NQRNNCCGYAFAAAGALEGQNFNLTKTLEILSKQQIIDCSIYYGNSNCYSGCILSKAYAY 590 NQ +AF+A GALEGQ F T L LS+Q ++DCS GN C +G ++ A+ Y Sbjct: 131 NQGQCGSCWAFSATGALEGQMFRKTGRLISLSEQNLVDCSGPQGNEGC-NGGLMDYAFQY 189 Query: 591 LADYGS-ELDEDYPFVGYNSNCKYDKSLATVKPYGFKYVSRGKEADLMNAVYNIGPISAA 767 + D G + +E YP+ +CKY+ + GF + + ++A LM AV +GPIS A Sbjct: 190 VQDNGGLDSEESYPYEATEESCKYNPKYSVANDTGFVDIPKQEKA-LMKAVATVGPISVA 248 Query: 768 IDASPNTFKQYKTGIYDDTSCSSNNVNHAVL 860 IDA +F YK GIY + CSS +++H VL Sbjct: 249 IDAGHESFLFYKEGIYFEPDCSSEDMDHGVL 279
>sp|P06797|CATL_MOUSE Cathepsin L precursor (Major excreted protein) (MEP) (p39 cysteine proteinase) [Contains: Cathepsin L heavy chain; Cathepsin L light chain] Length = 334 Score = 164 bits (415), Expect = 3e-40 Identities = 93/268 (34%), Positives = 144/268 (53%), Gaps = 1/268 (0%) Frame = +3 Query: 60 DWEDYKTIFNKKYSDETDLIRRNIWEENLKFIKQHNLQFDLGKTKFSVGLNEFSDMNQKE 239 +W +K+ + Y + RR IWE+N++ I+ HN ++ G+ FS+ +N F DM +E Sbjct: 28 EWHQWKSTHRRLYGTNEEEWRRAIWEKNMRMIQLHNGEYSNGQHGFSMEMNAFGDMTNEE 87 Query: 240 FQSNILSVXXXXXXXXXXXXXXXXXXLSRNDFITTPNNIKLPDSWDWREKGAVSPVGNQR 419 F+ + + P +K+P S DWREKG V+PV NQ Sbjct: 88 FRQVVNGYRHQKH--------------KKGRLFQEPLMLKIPKSVDWREKGCVTPVKNQG 133 Query: 420 NNCCGYAFAAAGALEGQNFNLTKTLEILSKQQIIDCSIYYGNSNCYSGCILSKAYAYLAD 599 +AF+A+G LEGQ F T L LS+Q ++DCS GN C +G ++ A+ Y+ + Sbjct: 134 QCGSCWAFSASGCLEGQMFLKTGKLISLSEQNLVDCSHAQGNQGC-NGGLMDFAFQYIKE 192 Query: 600 YGS-ELDEDYPFVGYNSNCKYDKSLATVKPYGFKYVSRGKEADLMNAVYNIGPISAAIDA 776 G + +E YP+ + +CKY A GF + + ++A LM AV +GPIS A+DA Sbjct: 193 NGGLDSEESYPYEAKDGSCKYRAEFAVANDTGFVDIPQQEKA-LMKAVATVGPISVAMDA 251 Query: 777 SPNTFKQYKTGIYDDTSCSSNNVNHAVL 860 S + + Y +GIY + +CSS N++H VL Sbjct: 252 SHPSLQFYSSGIYYEPNCSSKNLDHGVL 279
>sp|Q26636|CATL_SARPE Cathepsin L precursor [Contains: Cathepsin L heavy chain; Cathepsin L light chain] Length = 339 Score = 162 bits (409), Expect = 1e-39 Identities = 90/272 (33%), Positives = 145/272 (53%), Gaps = 2/272 (0%) Frame = +3 Query: 51 LNKDWEDYKTIFNKKYSDETD-LIRRNIWEENLKFIKQHNLQFDLGKTKFSVGLNEFSDM 227 + ++W YK K Y++E + R I+ EN I +HN F GK + +GLN+++DM Sbjct: 24 IKEEWHTYKLQHRKNYANEVEERFRMKIFNENRHKIAKHNQLFAQGKVSYKLGLNKYADM 83 Query: 228 NQKEFQSNILSVXXXXXXXXXXXXXXXXXXLSRNDFITTPNNIKLPDSWDWREKGAVSPV 407 EF+ + L +I P ++ +P S DWRE GAV+ V Sbjct: 84 LHHEFKETM-----NGYNHTLRQLMRERTGLVGATYI-PPAHVTVPKSVDWREHGAVTGV 137 Query: 408 GNQRNNCCGYAFAAAGALEGQNFNLTKTLEILSKQQIIDCSIYYGNSNCYSGCILSKAYA 587 +Q + +AF++ GALEGQ+F L LS+Q ++DCS YGN+ C +G ++ A+ Sbjct: 138 KDQGHCGSCWAFSSTGALEGQHFRKAGVLVSLSEQNLVDCSTKYGNNGC-NGGLMDNAFR 196 Query: 588 YLADYGS-ELDEDYPFVGYNSNCKYDKSLATVKPYGFKYVSRGKEADLMNAVYNIGPISA 764 Y+ D G + ++ YP+ G + +C ++K+ GF + G E + AV +GP+S Sbjct: 197 YIKDNGGIDTEKSYPYEGIDDSCHFNKATIGATDTGFVDIPEGDEEKMKKAVATMGPVSV 256 Query: 765 AIDASPNTFKQYKTGIYDDTSCSSNNVNHAVL 860 AIDAS +F+ Y G+Y++ C N++H VL Sbjct: 257 AIDASHESFQLYSEGVYNEPECDEQNLDHGVL 288
>sp|Q95029|CATL_DROME Cathepsin L precursor (Cysteine proteinase 1) [Contains: Cathepsin L heavy chain; Cathepsin L light chain] Length = 341 Score = 161 bits (408), Expect = 2e-39 Identities = 89/270 (32%), Positives = 145/270 (53%), Gaps = 2/270 (0%) Frame = +3 Query: 57 KDWEDYKTIFNKKYSDETD-LIRRNIWEENLKFIKQHNLQFDLGKTKFSVGLNEFSDMNQ 233 ++W +K K Y DET+ R I+ EN I +HN +F GK F + +N+++D+ Sbjct: 27 EEWHTFKLEHRKNYQDETEERFRLKIFNENKHKIAKHNQRFAEGKVSFKLAVNKYADLLH 86 Query: 234 KEFQSNILSVXXXXXXXXXXXXXXXXXXLSRNDFITTPNNIKLPDSWDWREKGAVSPVGN 413 EF+ + FI+ P ++ LP S DWR KGAV+ V + Sbjct: 87 HEFRQ----LMNGFNYTLHKQLRAADESFKGVTFIS-PAHVTLPKSVDWRTKGAVTAVKD 141 Query: 414 QRNNCCGYAFAAAGALEGQNFNLTKTLEILSKQQIIDCSIYYGNSNCYSGCILSKAYAYL 593 Q + +AF++ GALEGQ+F + L LS+Q ++DCS YGN+ C +G ++ A+ Y+ Sbjct: 142 QGHCGSCWAFSSTGALEGQHFRKSGVLVSLSEQNLVDCSTKYGNNGC-NGGLMDNAFRYI 200 Query: 594 ADYGS-ELDEDYPFVGYNSNCKYDKSLATVKPYGFKYVSRGKEADLMNAVYNIGPISAAI 770 D G + ++ YP+ + +C ++K GF + +G E + AV +GP+S AI Sbjct: 201 KDNGGIDTEKSYPYEAIDDSCHFNKGTVGATDRGFTDIPQGDEKKMAEAVATVGPVSVAI 260 Query: 771 DASPNTFKQYKTGIYDDTSCSSNNVNHAVL 860 DAS +F+ Y G+Y++ C + N++H VL Sbjct: 261 DASHESFQFYSEGVYNEPQCDAQNLDHGVL 290
Database: Non-redundant SwissProt sequences Posted date: Dec 6, 2005 7:40 AM Number of letters in database: 68,354,980 Number of sequences in database: 184,735 Database: swissprot.01 Posted date: Dec 6, 2005 8:18 AM Number of letters in database: 66,202,850 Number of sequences in database: 184,431 Lambda K H 0.318 0.134 0.401 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 79,244,214 Number of Sequences: 369166 Number of extensions: 1391484 Number of successful extensions: 4444 Number of sequences better than 10.0: 10 Number of HSP's better than 10.0 without gapping: 4008 Number of HSP's successfully gapped in prelim test: 0 Number of HSP's that attempted gapping in prelim test: 0 Number of HSP's gapped (non-prelim): 4178 length of database: 68,354,980 effective HSP length: 109 effective length of database: 48,218,865 effective search space used: 8534739105 frameshift window, decay const: 40, 0.1 T: 12 A: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.7 bits)