Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_027_A19
(754 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P52570|TSA_ONCVO Putative peroxiredoxin (Thioredoxin per... 208 1e-53
sp|O17433|1CPX_DIRIM 1-Cys peroxiredoxin (Thioredoxin perox... 207 3e-53
sp|O35244|PRDX6_RAT Peroxiredoxin 6 (Antioxidant protein 2)... 199 7e-51
sp|P30041|PRDX6_HUMAN Peroxiredoxin 6 (Antioxidant protein ... 197 2e-50
sp|O77834|PRDX6_BOVIN Peroxiredoxin 6 (Antioxidant protein ... 197 2e-50
sp|O08709|PRDX6_MOUSE Peroxiredoxin 6 (Antioxidant protein ... 194 3e-49
sp|P52573|REHY_ORYSA Probable peroxiredoxin (Thioredoxin pe... 186 4e-47
sp|P52572|REHY_HORVU Probable peroxiredoxin (Thioredoxin pe... 181 2e-45
sp|P34227|PRX1_YEAST Mitochondrial peroxiredoxin PRX1 (Thio... 175 1e-43
sp|O04005|REHY_ARATH Peroxiredoxin (Thioredoxin peroxidase)... 169 7e-42
>sp|P52570|TSA_ONCVO Putative peroxiredoxin (Thioredoxin peroxidase) (Thiol-specific
antioxidant)
Length = 232
Score = 208 bits (530), Expect = 1e-53
Identities = 106/223 (47%), Positives = 149/223 (66%), Gaps = 7/223 (3%)
Frame = +1
Query: 13 GTTFPTYKVKSTEGDLT-IPDYFG-ESWGLICTHPADFTPVCTTEFAKTVRIFSEFTKRN 186
G FP ++ ++ EG ++ D+ G +SW ++ +HP DFTPVCTTE A+ V++ EF KRN
Sbjct: 8 GNKFPDFQAETNEGFISSFYDWIGKDSWAILFSHPRDFTPVCTTELARLVQLAPEFKKRN 67
Query: 187 VKIVGISCDTIDNHKAWAADIQCLAKT----CDSDKSEKSGLPFPIIADTDRKLVTELGM 354
VK++G+SCD+ D+H WA DI L K CDS+K LP+PIIAD DR L TELGM
Sbjct: 68 VKLIGLSCDSADSHSKWADDILALYKMKCVGCDSEKK----LPYPIIADEDRSLATELGM 123
Query: 355 IDNLSRTAAGIPLPARAVYFLDPKRIVRASILYPASSGRSFDEIIRVIDSLQMSTKTGLV 534
+D R G L AR V+ + + ++ SILYPA++GR+FDEI+RV+DSLQ++ +
Sbjct: 124 MDPDERDEKGNTLTARCVFIIGSDKTLKLSILYPATTGRNFDEILRVVDSLQLTAVKLVA 183
Query: 535 TPENWNVGDDLIVPPTMSTEDAKKKFGD-VKVVPLPSGREYLR 660
TP +W GDD +V PT+ +AKK FG+ + + LPSG+ YLR
Sbjct: 184 TPVDWKDGDDCVVLPTIDDNEAKKLFGEKIHTIDLPSGKHYLR 226
>sp|O17433|1CPX_DIRIM 1-Cys peroxiredoxin (Thioredoxin peroxidase) (1-CysPxn)
Length = 235
Score = 207 bits (526), Expect = 3e-53
Identities = 104/225 (46%), Positives = 153/225 (68%), Gaps = 6/225 (2%)
Frame = +1
Query: 4 LTLGTTFPTYKVKSTEGDL-TIPDYFG-ESWGLICTHPADFTPVCTTEFAKTVRIFSEFT 177
+ LG FP ++ ++ EG + + D+ G +SW ++ +HP DFTPVCTTE A+ V++ EF
Sbjct: 5 ILLGDKFPDFRAETNEGFIPSFYDWIGKDSWAILFSHPRDFTPVCTTELARLVQLAPEFN 64
Query: 178 KRNVKIVGISCDTIDNHKAWAADIQCLAKT-CDSDKSEKSG--LPFPIIADTDRKLVTEL 348
KRNVK++G+SCD+ ++H+ W DI + K C+ + SG LPFPIIAD +R L TEL
Sbjct: 65 KRNVKLIGLSCDSAESHRKWVDDIMAVCKMKCNDGDTCCSGNKLPFPIIADENRFLATEL 124
Query: 349 GMIDNLSRTAAGIPLPARAVYFLDPKRIVRASILYPASSGRSFDEIIRVIDSLQMSTKTG 528
GM+D R G L AR V+ + P++ ++ SILYPA++GR+FDEI+RV+DSLQ++
Sbjct: 125 GMMDPDERDENGNALTARCVFIIGPEKTLKLSILYPATTGRNFDEILRVVDSLQLTAVKL 184
Query: 529 LVTPENWNVGDDLIVPPTMSTEDAKKKFGD-VKVVPLPSGREYLR 660
+ TP +W GDD +V PT+ +AKK FG+ + + LPSG+ YLR
Sbjct: 185 VATPVDWKDGDDCVVLPTIDDTEAKKLFGEKINTIELPSGKHYLR 229
>sp|O35244|PRDX6_RAT Peroxiredoxin 6 (Antioxidant protein 2) (1-Cys peroxiredoxin)
(1-Cys PRX) (Acidic calcium-independent phospholipase
A2) (aiPLA2) (Non-selenium glutathione peroxidase)
(NSGPx) (Thiol-specific antioxidant protein)
Length = 224
Score = 199 bits (506), Expect = 7e-51
Identities = 95/221 (42%), Positives = 142/221 (64%), Gaps = 1/221 (0%)
Frame = +1
Query: 4 LTLGTTFPTYKVKSTEGDLTIPDYFGESWGLICTHPADFTPVCTTEFAKTVRIFSEFTKR 183
L LG P ++ +T G + D+ G+SWG++ +HP DFTPVCTTE + ++ EF KR
Sbjct: 5 LLLGDEAPNFEANTTIGHIRFHDFLGDSWGILFSHPRDFTPVCTTELGRAAKLAPEFAKR 64
Query: 184 NVKIVGISCDTIDNHKAWAADIQCLAKTCDSDKSEKSGLPFPIIADTDRKLVTELGMIDN 363
NVK++ +S D++++H AW+ DI ++K LPFPII D DR L LGM+D
Sbjct: 65 NVKLIALSIDSVEDHFAWSKDINAYNGAAPTEK-----LPFPIIDDKDRDLAILLGMLDP 119
Query: 364 LSRTAAGIPLPARAVYFLDPKRIVRASILYPASSGRSFDEIIRVIDSLQMSTKTGLVTPE 543
+ G+P+ AR V+ P + ++ SILYPA++GR+FDEI+RV+DSLQ++ + TP
Sbjct: 120 AEKDEKGMPVTARVVFIFGPDKKLKLSILYPATTGRNFDEILRVVDSLQLTASNPVATPV 179
Query: 544 NWNVGDDLIVPPTMSTEDAKKKF-GDVKVVPLPSGREYLRY 663
+W G+ ++V PT+ E+AK+ F V LPSG++YLRY
Sbjct: 180 DWKKGESVMVLPTLPEEEAKQLFPKGVFTKELPSGKKYLRY 220
>sp|P30041|PRDX6_HUMAN Peroxiredoxin 6 (Antioxidant protein 2) (1-Cys peroxiredoxin)
(1-Cys PRX) (Acidic calcium-independent phospholipase
A2) (aiPLA2) (Non-selenium glutathione peroxidase)
(NSGPx) (24 kDa protein) (Liver 2D page spot 40) (Red
blood cells page spot 12)
Length = 224
Score = 197 bits (502), Expect = 2e-50
Identities = 98/221 (44%), Positives = 147/221 (66%), Gaps = 1/221 (0%)
Frame = +1
Query: 4 LTLGTTFPTYKVKSTEGDLTIPDYFGESWGLICTHPADFTPVCTTEFAKTVRIFSEFTKR 183
L LG P ++ +T G + D+ G+SWG++ +HP DFTPVCTTE + ++ EF KR
Sbjct: 5 LLLGDVAPNFEANTTVGRIRFHDFLGDSWGILFSHPRDFTPVCTTELGRAAKLAPEFAKR 64
Query: 184 NVKIVGISCDTIDNHKAWAADIQCLAKTCDSDKSEKSGLPFPIIADTDRKLVTELGMIDN 363
NVK++ +S D++++H AW+ DI A C+ + +EK LPFPII D +R+L LGM+D
Sbjct: 65 NVKLIALSIDSVEDHLAWSKDIN--AYNCE-EPTEK--LPFPIIDDRNRELAILLGMLDP 119
Query: 364 LSRTAAGIPLPARAVYFLDPKRIVRASILYPASSGRSFDEIIRVIDSLQMSTKTGLVTPE 543
+ G+P+ AR V+ P + ++ SILYPA++GR+FDEI+RV+ SLQ++ + + TP
Sbjct: 120 AEKDEKGMPVTARVVFVFGPDKKLKLSILYPATTGRNFDEILRVVISLQLTAEKRVATPV 179
Query: 544 NWNVGDDLIVPPTMSTEDAKKKF-GDVKVVPLPSGREYLRY 663
+W GD ++V PT+ E+AKK F V LPSG++YLRY
Sbjct: 180 DWKDGDSVMVLPTIPEEEAKKLFPKGVFTKELPSGKKYLRY 220
>sp|O77834|PRDX6_BOVIN Peroxiredoxin 6 (Antioxidant protein 2) (1-Cys peroxiredoxin)
(1-Cys PRX) (Acidic calcium-independent phospholipase
A2) (aiPLA2) (Non-selenium glutathione peroxidase)
(NSGPx) (PHGPx) (Ciliary body glutathione peroxidase)
Length = 224
Score = 197 bits (502), Expect = 2e-50
Identities = 97/221 (43%), Positives = 143/221 (64%), Gaps = 1/221 (0%)
Frame = +1
Query: 4 LTLGTTFPTYKVKSTEGDLTIPDYFGESWGLICTHPADFTPVCTTEFAKTVRIFSEFTKR 183
L LG P ++ +T G + DY G+SWG++ +HP DFTPVCTTE + ++ EF KR
Sbjct: 5 LLLGDEAPNFEANTTIGRIRFHDYLGDSWGILFSHPRDFTPVCTTELGRAAKLAPEFAKR 64
Query: 184 NVKIVGISCDTIDNHKAWAADIQCLAKTCDSDKSEKSGLPFPIIADTDRKLVTELGMIDN 363
NVK++ +S D++++H AW+ DI ++K LPFPII D +R L +LGM+D
Sbjct: 65 NVKMIALSIDSVEDHLAWSKDINAYNGEEPTEK-----LPFPIIDDKNRDLAIQLGMLDP 119
Query: 364 LSRTAAGIPLPARAVYFLDPKRIVRASILYPASSGRSFDEIIRVIDSLQMSTKTGLVTPE 543
+ G+P+ AR V+ P + ++ SILYPA++GR+FDEI+RVI SLQ++ + + TP
Sbjct: 120 AEKDEKGMPVTARVVFIFGPDKKLKLSILYPATTGRNFDEILRVIISLQLTAEKRVATPV 179
Query: 544 NWNVGDDLIVPPTMSTEDAKKKF-GDVKVVPLPSGREYLRY 663
+W GD ++V PT+ E+AKK F V LPSG++YLRY
Sbjct: 180 DWKNGDSVMVLPTIPEEEAKKLFPKGVFTKELPSGKKYLRY 220
>sp|O08709|PRDX6_MOUSE Peroxiredoxin 6 (Antioxidant protein 2) (1-Cys peroxiredoxin)
(1-Cys PRX) (Acidic calcium-independent phospholipase
A2) (aiPLA2) (Non-selenium glutathione peroxidase)
(NSGPx)
Length = 224
Score = 194 bits (492), Expect = 3e-49
Identities = 94/221 (42%), Positives = 142/221 (64%), Gaps = 1/221 (0%)
Frame = +1
Query: 4 LTLGTTFPTYKVKSTEGDLTIPDYFGESWGLICTHPADFTPVCTTEFAKTVRIFSEFTKR 183
L LG P ++ +T G + D+ G+SWG++ +HP DFTPVCTTE + ++ EF KR
Sbjct: 5 LLLGDEAPNFEANTTIGRIRFHDFLGDSWGILFSHPRDFTPVCTTELGRAAKLAPEFAKR 64
Query: 184 NVKIVGISCDTIDNHKAWAADIQCLAKTCDSDKSEKSGLPFPIIADTDRKLVTELGMIDN 363
NVK++ +S D++++H AW+ DI ++K LPFPII D R L LGM+D
Sbjct: 65 NVKLIALSIDSVEDHLAWSKDINAYNGETPTEK-----LPFPIIDDKGRDLAILLGMLDP 119
Query: 364 LSRTAAGIPLPARAVYFLDPKRIVRASILYPASSGRSFDEIIRVIDSLQMSTKTGLVTPE 543
+ + +P+ AR V+ P + ++ SILYPA++GR+FDEI+RV+DSLQ++ + TP
Sbjct: 120 VEKDDNNMPVTARVVFIFGPDKKLKLSILYPATTGRNFDEILRVVDSLQLTGTKPVATPV 179
Query: 544 NWNVGDDLIVPPTMSTEDAKKKF-GDVKVVPLPSGREYLRY 663
+W G+ ++V PT+S E+AK+ F V LPSG++YLRY
Sbjct: 180 DWKKGESVMVVPTLSEEEAKQCFPKGVFTKELPSGKKYLRY 220
>sp|P52573|REHY_ORYSA Probable peroxiredoxin (Thioredoxin peroxidase) (RAB24 protein)
Length = 220
Score = 186 bits (473), Expect = 4e-47
Identities = 90/223 (40%), Positives = 137/223 (61%), Gaps = 1/223 (0%)
Frame = +1
Query: 4 LTLGTTFPTYKVKSTEGDLTIPDYFGESWGLICTHPADFTPVCTTEFAKTVRIFSEFTKR 183
LT+G T P ++ ST G + I D+ G+++ ++ +HP DFTPVCTTE A EF KR
Sbjct: 4 LTIGDTVPNLELDSTHGKIRIHDFVGDTYVILFSHPGDFTPVCTTELAAMAAYAKEFDKR 63
Query: 184 NVKIVGISCDTIDNHKAWAADIQCLAKTCDSDKSEKSGLPFPIIADTDRKLVTELGMIDN 363
VK++GISCD + +HK W DI+ + + +PI+AD R+ + +L M+D
Sbjct: 64 GVKLLGISCDDVQSHKDWFKDIEAY--------KPGNRVTYPIMADPSREAIKQLNMVDP 115
Query: 364 LSRTAAGIPLPARAVYFLDPKRIVRASILYPASSGRSFDEIIRVIDSLQMSTKTGLVTPE 543
+ + G LP+RA++ + P + V+ S LYPA GR+ DE++R +D+LQ + KT L TP
Sbjct: 116 DEKDSNGGHLPSRALHIVGPDKKVKLSFLYPACVGRNMDEVVRAVDALQTAAKTRLATPV 175
Query: 544 NWNVGDDLIVPPTMSTEDAKKKFGD-VKVVPLPSGREYLRYAK 669
NW G+ ++PP +S ++AK+KF LPSG+ YLR+ K
Sbjct: 176 NWKPGEPFVIPPGVSDDEAKEKFPQGFDTADLPSGKGYLRFTK 218
>sp|P52572|REHY_HORVU Probable peroxiredoxin (Thioredoxin peroxidase) (Rehydrin homolog)
(B15C)
Length = 218
Score = 181 bits (458), Expect = 2e-45
Identities = 89/223 (39%), Positives = 133/223 (59%), Gaps = 1/223 (0%)
Frame = +1
Query: 4 LTLGTTFPTYKVKSTEGDLTIPDYFGESWGLICTHPADFTPVCTTEFAKTVRIFSEFTKR 183
LT+G T P ++ ST G + I DY G + ++ +HP DFTPVCTTE A EF KR
Sbjct: 4 LTIGDTVPNLELDSTHGKIRIHDYVGNGYVILFSHPGDFTPVCTTELAAMANYAKEFEKR 63
Query: 184 NVKIVGISCDTIDNHKAWAADIQCLAKTCDSDKSEKSGLPFPIIADTDRKLVTELGMIDN 363
VK++GISCD + +HK W DI+ S + +PI+AD DR + +L M+D
Sbjct: 64 GVKLLGISCDDVQSHKEWTKDIEAY--------KPGSKVTYPIMADPDRSAIKQLNMVDP 115
Query: 364 LSRTAAGIPLPARAVYFLDPKRIVRASILYPASSGRSFDEIIRVIDSLQMSTKTGLVTPE 543
+ A G LP+R ++ + P ++V+ S LYP+ +GR+ DE++R +DSL + K + TP
Sbjct: 116 DEKDAQG-QLPSRTLHIVGPDKVVKLSFLYPSCTGRNMDEVVRAVDSLLTAAKHKVATPA 174
Query: 544 NWNVGDDLIVPPTMSTEDAKKKFGD-VKVVPLPSGREYLRYAK 669
NW G+ +++ P +S E+AKK F + LPS + YLR+ K
Sbjct: 175 NWKPGECVVIAPGVSDEEAKKMFPQGFETADLPSKKGYLRFTK 217
>sp|P34227|PRX1_YEAST Mitochondrial peroxiredoxin PRX1 (Thioredoxin reductase) (1-Cys
Prx) (Mitochondrial thiol peroxidase) (mTPx)
Length = 261
Score = 175 bits (444), Expect = 1e-43
Identities = 86/225 (38%), Positives = 135/225 (60%), Gaps = 2/225 (0%)
Frame = +1
Query: 4 LTLGTTFPTYKVKSTEGDLTIPDYFGESWGLICTHPADFTPVCTTEFAKTVRIFSEFTKR 183
L + + P + +T G + DY G+SWG++ +HPADFTPVCTTE + ++ EF KR
Sbjct: 49 LRINSDAPNFDADTTVGKINFYDYLGDSWGVLFSHPADFTPVCTTEVSAFAKLKPEFDKR 108
Query: 184 NVKIVGISCDTIDNHKAWAADIQCLAKTCDSDKSEKSGLPFPIIADTDRKLVTELGMID- 360
NVK++G+S + +++H+ W DI+ +AK + FPII DT R + M+D
Sbjct: 109 NVKLIGLSVEDVESHEKWIQDIKEIAKV--------KNVGFPIIGDTFRNVAFLYDMVDA 160
Query: 361 -NLSRTAAGIPLPARAVYFLDPKRIVRASILYPASSGRSFDEIIRVIDSLQMSTKTGLVT 537
G R+V+ +DPK+ +R YP++ GR+ E++RVID+LQ++ K G+VT
Sbjct: 161 EGFKNINDGSLKTVRSVFVIDPKKKIRLIFTYPSTVGRNTSEVLRVIDALQLTDKEGVVT 220
Query: 538 PENWNVGDDLIVPPTMSTEDAKKKFGDVKVVPLPSGREYLRYAKN 672
P NW DD+I+PP++S ++AK KFG + + YLR+ K+
Sbjct: 221 PINWQPADDVIIPPSVSNDEAKAKFGQFNEI-----KPYLRFTKS 260
>sp|O04005|REHY_ARATH Peroxiredoxin (Thioredoxin peroxidase) (Rehydrin homolog)
Length = 216
Score = 169 bits (428), Expect = 7e-42
Identities = 84/225 (37%), Positives = 133/225 (59%), Gaps = 3/225 (1%)
Frame = +1
Query: 4 LTLGTTFPTYKVKSTEGDLTIPDYFGESWGLICTHPADFTPVCTTEFAKTVRIFSEFTKR 183
+TLG T P +V++T + DYF SW ++ +HP DFTPVCTTE + EF KR
Sbjct: 4 ITLGDTVPNLEVETTHDKFKLHDYFANSWTVLFSHPGDFTPVCTTELGAMAKYAHEFDKR 63
Query: 184 NVKIVGISCDTIDNHKAWAADIQCLAKTCDSDKSEKSGLPFPIIADTDRKLVTELGMIDN 363
VK++G+SCD + +HK W DI+ + S + +PIIAD +++++ +L MID
Sbjct: 64 GVKLLGLSCDDVQSHKDWIKDIEAF--------NHGSKVNYPIIADPNKEIIPQLNMIDP 115
Query: 364 LSRTAAGIPLPARAVYFLDPKRIVRASILYPASSGRSFDEIIRVIDSLQMSTK--TGLVT 537
+ P+RA++ + P ++ S LYP+++GR+ DE++R +DSL M++K + T
Sbjct: 116 IENG------PSRALHIVGPDSKIKLSFLYPSTTGRNMDEVLRALDSLLMASKHNNKIAT 169
Query: 538 PENWNVGDDLIVPPTMSTEDAKKKFGD-VKVVPLPSGREYLRYAK 669
P NW +++ P +S E+AKK F K LPS + YLR+ +
Sbjct: 170 PVNWKPDQPVVISPAVSDEEAKKMFPQGFKTADLPSKKGYLRHTE 214
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 87,020,905
Number of Sequences: 369166
Number of extensions: 1795969
Number of successful extensions: 5584
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 5262
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 5447
length of database: 68,354,980
effective HSP length: 108
effective length of database: 48,403,600
effective search space used: 6873311200
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)