Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_026_P10
(872 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P05208|ELA2_MOUSE Elastase-2 precursor 83 9e-16
sp|P08419|ELA2_PIG Elastase-2 precursor 83 1e-15
sp|Q867B0|ELA1_CANFA Elastase-1 precursor 74 5e-13
sp|P00774|ELA2_RAT Elastase-2 precursor 74 7e-13
sp|P06868|PLMN_BOVIN Plasminogen precursor [Contains: Plasm... 73 1e-12
sp|Q9Y5Y6|ST14_HUMAN Suppressor of tumorigenicity 14 (Matri... 73 1e-12
sp|P08218|ELA2B_HUMAN Elastase-2B precursor 72 2e-12
sp|Q9UNI1|ELA1_HUMAN Elastase-1 precursor 71 3e-12
sp|P08217|ELA2A_HUMAN Elastase-2A precursor 70 8e-12
sp|Q9JIQ8|TMPS2_MOUSE Transmembrane protease, serine 2 (Epi... 70 8e-12
>sp|P05208|ELA2_MOUSE Elastase-2 precursor
Length = 271
Score = 83.2 bits (204), Expect = 9e-16
Identities = 47/153 (30%), Positives = 75/153 (49%), Gaps = 3/153 (1%)
Frame = +1
Query: 418 VNCGIKPMEIEN---KIIGGEDSRKNAWPWHVGLYVNVRKRSIYICGGTLINPGWVVTAA 588
++CG E+E+ +++GG+++ N WPW V L V R + CGG+L+ WV+TAA
Sbjct: 15 LSCGYPTYEVEDDVSRVVGGQEATPNTWPWQVSLQVLSSGRWRHNCGGSLVANNWVLTAA 74
Query: 589 HCLKTIEAVNSVPLGEMIDTRKYDLYDKFHVVINDHDRTTDDADEISRKLSYFIINPLFR 768
HCL Y + V++ H + A + ++S +++ +
Sbjct: 75 HCLSN--------------------YQTYRVLLGAHSLSNPGAGSAAVQVSKLVVHQRWN 114
Query: 769 ADYSSNLYDIALLKLDKPVIPSKVVNINFPCVP 867
+ N YDIAL+KL PV SK NI C+P
Sbjct: 115 SQNVGNGYDIALIKLASPVTLSK--NIQTACLP 145
>sp|P08419|ELA2_PIG Elastase-2 precursor
Length = 269
Score = 82.8 bits (203), Expect = 1e-15
Identities = 47/152 (30%), Positives = 79/152 (51%), Gaps = 2/152 (1%)
Frame = +1
Query: 418 VNCGIKPMEIEN--KIIGGEDSRKNAWPWHVGLYVNVRKRSIYICGGTLINPGWVVTAAH 591
++CG+ P + +++GGED+R N+WPW V L + + + CGGTL++ WV+TAAH
Sbjct: 15 LSCGL-PANLPQLPRVVGGEDARPNSWPWQVSLQYDSSGQWRHTCGGTLVDQSWVLTAAH 73
Query: 592 CLKTIEAVNSVPLGEMIDTRKYDLYDKFHVVINDHDRTTDDADEISRKLSYFIINPLFRA 771
C+ + + VV+ H +T++ ++ K+S +++ + +
Sbjct: 74 CISSSRT--------------------YRVVLGRHSLSTNEPGSLAVKVSKLVVHQDWNS 113
Query: 772 DYSSNLYDIALLKLDKPVIPSKVVNINFPCVP 867
+ SN DIALLKL PV S I C+P
Sbjct: 114 NQLSNGNDIALLKLASPV--SLTDKIQLGCLP 143
>sp|Q867B0|ELA1_CANFA Elastase-1 precursor
Length = 258
Score = 73.9 bits (180), Expect = 5e-13
Identities = 41/136 (30%), Positives = 68/136 (50%)
Frame = +1
Query: 442 EIENKIIGGEDSRKNAWPWHVGLYVNVRKRSIYICGGTLINPGWVVTAAHCLKTIEAVNS 621
E +++GG ++R+N+WP + L + + CGGTLI WV+TAAHC+
Sbjct: 14 ETNARVVGGTEARRNSWPSQISLQYLSGGKWYHTCGGTLIRQNWVMTAAHCV-------- 65
Query: 622 VPLGEMIDTRKYDLYDKFHVVINDHDRTTDDADEISRKLSYFIINPLFRADYSSNLYDIA 801
D F VVI +H+ + +D E S + +++P + ++ S YDIA
Sbjct: 66 ------------DRTMTFRVVIGEHNLSQNDGTEQSASVQKIVVHPYWNSNDVSAGYDIA 113
Query: 802 LLKLDKPVIPSKVVNI 849
LL+L + V + V +
Sbjct: 114 LLRLAQKVTLNSYVQL 129
>sp|P00774|ELA2_RAT Elastase-2 precursor
Length = 271
Score = 73.6 bits (179), Expect = 7e-13
Identities = 42/151 (27%), Positives = 78/151 (51%), Gaps = 4/151 (2%)
Frame = +1
Query: 418 VNCGIKPMEIEN---KIIGGEDSRKNAWPWHVGLYVNVRKRSIYICGGTLINPGWVVTAA 588
++CG E+++ +++GG+++ N+WPW V L + + CGG+L+ WV+TAA
Sbjct: 15 LSCGYPTYEVQHDVSRVVGGQEASPNSWPWQVSLQYLSSGKWHHTCGGSLVANNWVLTAA 74
Query: 589 HCLKTIEAVNSVPLGEMIDTRKYDLYDKFHVVINDHDRTTDDADEISRKLSYFIINPLFR 768
HC+ ++R Y V++ H +T ++ ++ ++S +++ +
Sbjct: 75 HCIS--------------NSRTY------RVLLGRHSLSTSESGSLAVQVSKLVVHEKWN 114
Query: 769 ADYSSNLYDIALLKLDKPV-IPSKVVNINFP 858
A SN DIAL+KL PV + SK+ P
Sbjct: 115 AQKLSNGNDIALVKLASPVALTSKIQTACLP 145
>sp|P06868|PLMN_BOVIN Plasminogen precursor [Contains: Plasmin heavy chain A; Activation
peptide; Plasmin heavy chain A, short form; Plasmin
light chain B]
Length = 812
Score = 72.8 bits (177), Expect = 1e-12
Identities = 47/144 (32%), Positives = 74/144 (51%), Gaps = 3/144 (2%)
Frame = +1
Query: 421 NCG---IKPMEIENKIIGGEDSRKNAWPWHVGLYVNVRKRSIYICGGTLINPGWVVTAAH 591
+CG ++P + +I+GG S+ ++WPW V L R+ S + CGGTLI+P WV+TAAH
Sbjct: 569 DCGKPKVEPKKCSGRIVGGCVSKPHSWPWQVSL----RRSSRHFCGGTLISPKWVLTAAH 624
Query: 592 CLKTIEAVNSVPLGEMIDTRKYDLYDKFHVVINDHDRTTDDADEISRKLSYFIINPLFRA 771
CL I A++ + V++ H+ + + + ++ LFR
Sbjct: 625 CLDNILALSF-----------------YKVILGAHNEKVRE-----QSVQEIPVSRLFRE 662
Query: 772 DYSSNLYDIALLKLDKPVIPSKVV 843
+ DIALLKL +P I +K V
Sbjct: 663 PSQA---DIALLKLSRPAIITKEV 683
>sp|Q9Y5Y6|ST14_HUMAN Suppressor of tumorigenicity 14 (Matriptase) (Membrane-type serine
protease 1) (MT-SP1) (Prostamin) (Serine protease
TADG-15) (Tumor associated differentially-expressed
gene-15 protein)
Length = 855
Score = 72.8 bits (177), Expect = 1e-12
Identities = 46/144 (31%), Positives = 77/144 (53%), Gaps = 3/144 (2%)
Frame = +1
Query: 421 NCGIKPMEIENKIIGGEDSRKNAWPWHVGLYVNVRKRSIYICGGTLINPGWVVTAAHCLK 600
+CG++ + +++GG D+ + WPW V L+ + +ICG +LI+P W+V+AAHC
Sbjct: 603 DCGLRSFTRQARVVGGTDADEGEWPWQVSLHALGQG---HICGASLISPNWLVSAAHC-- 657
Query: 601 TIEAVNSVPLGEMIDTRKYDLYD--KFHVVINDHDRTTDDADEI-SRKLSYFIINPLFRA 771
ID R + D ++ + HD++ A + R+L I +P F
Sbjct: 658 ------------YIDDRGFRYSDPTQWTAFLGLHDQSQRSAPGVQERRLKRIISHPFFN- 704
Query: 772 DYSSNLYDIALLKLDKPVIPSKVV 843
D++ + YDIALL+L+KP S +V
Sbjct: 705 DFTFD-YDIALLELEKPAEYSSMV 727
>sp|P08218|ELA2B_HUMAN Elastase-2B precursor
Length = 269
Score = 72.4 bits (176), Expect = 2e-12
Identities = 41/151 (27%), Positives = 75/151 (49%), Gaps = 1/151 (0%)
Frame = +1
Query: 418 VNCGIKPMEIE-NKIIGGEDSRKNAWPWHVGLYVNVRKRSIYICGGTLINPGWVVTAAHC 594
++CG+ + ++++GGE++R N+WPW V L + + + CGG+LI WV+TAAHC
Sbjct: 15 LSCGVSTYAPDMSRMLGGEEARPNSWPWQVSLQYSSNGQWYHTCGGSLIANSWVLTAAHC 74
Query: 595 LKTIEAVNSVPLGEMIDTRKYDLYDKFHVVINDHDRTTDDADEISRKLSYFIINPLFRAD 774
+ + + V++ H+ ++ ++ +S +++ + ++
Sbjct: 75 ISSSRI--------------------YRVMLGQHNLYVAESGSLAVSVSKIVVHKDWNSN 114
Query: 775 YSSNLYDIALLKLDKPVIPSKVVNINFPCVP 867
S DIALLKL PV S I C+P
Sbjct: 115 QVSKGNDIALLKLANPV--SLTDKIQLACLP 143
>sp|Q9UNI1|ELA1_HUMAN Elastase-1 precursor
Length = 258
Score = 71.2 bits (173), Expect = 3e-12
Identities = 39/136 (28%), Positives = 64/136 (47%)
Frame = +1
Query: 442 EIENKIIGGEDSRKNAWPWHVGLYVNVRKRSIYICGGTLINPGWVVTAAHCLKTIEAVNS 621
E +++GG ++ +N+WP + L + CGGTLI WV+TAAHC+
Sbjct: 14 ETNARVVGGTEAGRNSWPSQISLQYRSGGSRYHTCGGTLIRQNWVMTAAHCV-------- 65
Query: 622 VPLGEMIDTRKYDLYDKFHVVINDHDRTTDDADEISRKLSYFIINPLFRADYSSNLYDIA 801
D F VV DH+ + +D E + +++P + +D + YDIA
Sbjct: 66 ------------DYQKTFRVVAGDHNLSQNDGTEQYVSVQKIVVHPYWNSDNVAAGYDIA 113
Query: 802 LLKLDKPVIPSKVVNI 849
LL+L + V + V +
Sbjct: 114 LLRLAQSVTLNSYVQL 129
>sp|P08217|ELA2A_HUMAN Elastase-2A precursor
Length = 269
Score = 70.1 bits (170), Expect = 8e-12
Identities = 39/138 (28%), Positives = 67/138 (48%)
Frame = +1
Query: 454 KIIGGEDSRKNAWPWHVGLYVNVRKRSIYICGGTLINPGWVVTAAHCLKTIEAVNSVPLG 633
+++GGE++R N+WPW V L + + + CGG+LI WV+TAAHC+ +
Sbjct: 28 RVVGGEEARPNSWPWQVSLQYSSNGKWYHTCGGSLIANSWVLTAAHCISSSRT------- 80
Query: 634 EMIDTRKYDLYDKFHVVINDHDRTTDDADEISRKLSYFIINPLFRADYSSNLYDIALLKL 813
+ V + H+ ++ ++ +S +++ + ++ S DIALLKL
Sbjct: 81 -------------YRVGLGRHNLYVAESGSLAVSVSKIVVHKDWNSNQISKGNDIALLKL 127
Query: 814 DKPVIPSKVVNINFPCVP 867
PV S I C+P
Sbjct: 128 ANPV--SLTDKIQLACLP 143
>sp|Q9JIQ8|TMPS2_MOUSE Transmembrane protease, serine 2 (Epitheliasin) (Plasmic
transmembrane protein X) [Contains: Transmembrane
protease, serine 2 non-catalytic chain; Transmembrane
protease, serine 2 catalytic chain]
Length = 490
Score = 70.1 bits (170), Expect = 8e-12
Identities = 31/89 (34%), Positives = 58/89 (65%)
Frame = +1
Query: 334 IYEKMSCSDIKSCEKTNYSTNLNISTFPVNCGIKPMEIENKIIGGEDSRKNAWPWHVGLY 513
+Y+K+ SD SC S+ + +S + CG++ ++ +++I+GG ++ WPW V L+
Sbjct: 220 LYKKLYHSD--SC-----SSRMVVSLRCIECGVRSVKRQSRIVGGLNASPGDWPWQVSLH 272
Query: 514 VNVRKRSIYICGGTLINPGWVVTAAHCLK 600
V + +++CGG++I P W+VTAAHC++
Sbjct: 273 V----QGVHVCGGSIITPEWIVTAAHCVE 297
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 95,831,871
Number of Sequences: 369166
Number of extensions: 1946706
Number of successful extensions: 5987
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 5403
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 5673
length of database: 68,354,980
effective HSP length: 110
effective length of database: 48,034,130
effective search space used: 8646143400
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)