Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_026_P04
(854 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q27778|K6PF_SCHMA 6-phosphofructokinase (Phosphofructoki... 414 e-115
sp|P47857|K6PF_MOUSE 6-phosphofructokinase, muscle type (Ph... 369 e-102
sp|P52034|K6PF_DROME 6-phosphofructokinase (Phosphofructoki... 369 e-102
sp|Q60HD9|K6PF_MACFA 6-phosphofructokinase, muscle type (Ph... 369 e-102
sp|P08237|K6PF_HUMAN 6-phosphofructokinase, muscle type (Ph... 369 e-102
sp|P52784|K6PF_CANFA 6-phosphofructokinase, muscle type (Ph... 368 e-101
sp|Q867C9|K6PF_HORSE 6-phosphofructokinase, muscle type (Ph... 367 e-101
sp|P47858|K6PF_RAT 6-phosphofructokinase, muscle type (Phos... 366 e-101
sp|P00511|K6PF_RABIT 6-phosphofructokinase, muscle type (Ph... 365 e-101
sp|Q01813|K6PP_HUMAN 6-phosphofructokinase type C (Phosphof... 358 1e-98
>sp|Q27778|K6PF_SCHMA 6-phosphofructokinase (Phosphofructokinase) (Phosphohexokinase)
Length = 781
Score = 414 bits (1064), Expect = e-115
Identities = 202/284 (71%), Positives = 237/284 (83%)
Frame = +1
Query: 1 MQLGGTVIGSARCMDFKTREGLLKAAKNLIDRNITNLVVIGGDGSLTGANYFRLEWNSLL 180
+QLGGT IGSARCMDF+ R G LKAA+NL+ ITNLVVIGGDGSLTGAN FR EW+SLL
Sbjct: 79 LQLGGTKIGSARCMDFRERYGRLKAAENLVKNQITNLVVIGGDGSLTGANLFRAEWSSLL 138
Query: 181 KELLEQNRITEDQRKKCGHLNIVGMVGSIDNDFCGTDMTIGTDSALHRIIEACDAITSTA 360
+EL+ N+I+ + K+ LNIVG+VGSIDNDFCGTDMTIG DSALHRIIEA DAI++TA
Sbjct: 139 EELVTSNKISAESAKQFHRLNIVGLVGSIDNDFCGTDMTIGADSALHRIIEATDAISTTA 198
Query: 361 QSHQRCFIMEVMGRHCGYXXXXXXXXSEAEWVFIPEMPPGPNWENKLCQKLQINRDNGQR 540
SHQRCFI+EVMGRHCGY EA+WVFIPEMPP +W KLC KL++NR++GQR
Sbjct: 199 HSHQRCFILEVMGRHCGYLALVASMACEADWVFIPEMPPTDDWREKLCHKLRMNREHGQR 258
Query: 541 VNIILVSEGAIDNNCNPITSDQIKNLIVSKLNIDTRVTVLGHVQRGGNPSAFDRILGIRM 720
VNII+V+EGAID C PIT + +KNLIVS+L +DTR+TVLGHVQRGG+PSAFDRILG RM
Sbjct: 259 VNIIMVAEGAIDRACKPITCEIVKNLIVSELQLDTRITVLGHVQRGGSPSAFDRILGSRM 318
Query: 721 GAEAVLALMDADRNLNSEASVISIDGNQTVRVPLLKCVEKTRAV 852
GAEAVLALMDADR+ N + VIS+DGNQ VRVPL+KCV++TR V
Sbjct: 319 GAEAVLALMDADRDPNLPSCVISLDGNQAVRVPLVKCVDRTRQV 362
Score = 81.6 bits (200), Expect = 2e-15
Identities = 73/248 (29%), Positives = 119/248 (47%), Gaps = 5/248 (2%)
Frame = +1
Query: 7 LGGTVIGSARCMDFKTREGLLKAAKNLIDRNITNLVVIGGDGSLTGANYFRLEWNSLLKE 186
+GG+++G+ R D G+ K A + ++ L++IGG E + E
Sbjct: 470 MGGSMLGTRR--DTPNGLGIDKVAAKFKELKLSGLLIIGG-----------FEAYECMIE 516
Query: 187 LLEQNRITEDQRKKCGHLNI-VGMV-GSIDNDFCGTDMTIGTDSALHRIIEACDAITSTA 360
L+E R+K L I + MV +I N+ GTD ++G D+AL+ I D I +A
Sbjct: 517 LVEG-------REKYPELCIPMAMVPATISNNVPGTDFSLGCDTALNEITSVLDKIKQSA 569
Query: 361 Q-SHQRCFIMEVMGRHCGYXXXXXXXXSEAEWVFIPEMPPGPNWENKLCQKLQINRDNGQ 537
+ +R F++E MG +CGY A+ +I E P + + L+ D+
Sbjct: 570 LGTKRRVFVVETMGGYCGYLATMSALAGGADAAYIFEEPFTIDDLREDVVHLRAKIDDNV 629
Query: 538 RVNIILVSEGAIDNNCNPITSDQIKNLIVSKLN--IDTRVTVLGHVQRGGNPSAFDRILG 711
+ ++L ++ I N ITS+ I L + D R VLGH+Q+G PS FDR LG
Sbjct: 630 KRGLVLRADMLI----NTITSEFIHQLYAQEGQGIFDCRCNVLGHMQQGDRPSPFDRSLG 685
Query: 712 IRMGAEAV 735
+ ++A+
Sbjct: 686 TKFASKAI 693
>sp|P47857|K6PF_MOUSE 6-phosphofructokinase, muscle type (Phosphofructokinase 1)
(Phosphohexokinase) (Phosphofructo-1-kinase isozyme A)
(PFK-A) (Phosphofructokinase-M)
Length = 780
Score = 369 bits (948), Expect = e-102
Identities = 181/284 (63%), Positives = 220/284 (77%)
Frame = +1
Query: 1 MQLGGTVIGSARCMDFKTREGLLKAAKNLIDRNITNLVVIGGDGSLTGANYFRLEWNSLL 180
+QLGGTVIGSARC DF+ REG L+AA NL+ R ITNL VIGGDGSLTGA+ FR EW+ LL
Sbjct: 77 LQLGGTVIGSARCKDFREREGRLRAAHNLVKRGITNLCVIGGDGSLTGADTFRSEWSDLL 136
Query: 181 KELLEQNRITEDQRKKCGHLNIVGMVGSIDNDFCGTDMTIGTDSALHRIIEACDAITSTA 360
+L + +IT ++ K +LNIVG+VGSIDNDFCGTDMTIGTDSALHRI+E DAIT+TA
Sbjct: 137 NDLQKDGKITAEEATKSSYLNIVGLVGSIDNDFCGTDMTIGTDSALHRIVEIVDAITTTA 196
Query: 361 QSHQRCFIMEVMGRHCGYXXXXXXXXSEAEWVFIPEMPPGPNWENKLCQKLQINRDNGQR 540
QSHQR F++EVMGRHCGY A+WVFIPE PP +WE LC++L R G R
Sbjct: 197 QSHQRTFVLEVMGRHCGYLALVTSLSCGADWVFIPECPPDDDWEEHLCRRLSETRTRGSR 256
Query: 541 VNIILVSEGAIDNNCNPITSDQIKNLIVSKLNIDTRVTVLGHVQRGGNPSAFDRILGIRM 720
+NII+V+EGAID N PITS+ IKNL+V +L DTRVTVLGHVQRGG PSAFDRILG RM
Sbjct: 257 LNIIIVAEGAIDKNGKPITSEDIKNLVVKRLGYDTRVTVLGHVQRGGTPSAFDRILGSRM 316
Query: 721 GAEAVLALMDADRNLNSEASVISIDGNQTVRVPLLKCVEKTRAV 852
G EAV+AL++ ++ A V+S+ GNQ VR+PL++CV+ T+ V
Sbjct: 317 GVEAVMALLEG--TPDTPACVVSLSGNQAVRLPLMECVQVTKDV 358
Score = 94.0 bits (232), Expect = 5e-19
Identities = 82/250 (32%), Positives = 123/250 (49%), Gaps = 8/250 (3%)
Frame = +1
Query: 10 GGTVIGSARCMDFKTREGLLKAAKNLIDRNITNLVVIGGDGSLTGANYFRLEWNSLLKEL 189
GG+ +G+ R + K E + + N+ NI LV+IGG + TG EL
Sbjct: 463 GGSKLGTKRTLPKKNLEQI---SANITKFNIQGLVIIGGFEAYTGG-----------LEL 508
Query: 190 LEQNRITEDQRKKCGHLNIVGMV--GSIDNDFCGTDMTIGTDSALHRIIEACDAIT-STA 360
+E RK+ L I +V ++ N+ G+D +IG D+AL+ I CD I S A
Sbjct: 509 MEG-------RKQFDELCIPFVVIPATVSNNVPGSDFSIGADTALNTICTTCDRIKQSAA 561
Query: 361 QSHQRCFIMEVMGRHCGYXXXXXXXXSEAEWVFIPEMPPGPNWENKLCQKLQINRDNGQR 540
+ +R FI+E MG +CGY + A+ +I E P + LQ+N ++ +
Sbjct: 562 GTKRRVFIIETMGGYCGYLATMAGLAAGADAAYIFEEP-------FTIRDLQVNVEHLVQ 614
Query: 541 VNIILVSEGAIDNN--CNP-ITSDQIKNLIVS--KLNIDTRVTVLGHVQRGGNPSAFDRI 705
V G + N CN T+D I NL K D+R VLGH+Q+GG+P+ FDR
Sbjct: 615 KMKTTVKRGLVLRNEKCNENYTTDFIFNLYSEEGKGIFDSRKNVLGHMQQGGSPTPFDRN 674
Query: 706 LGIRMGAEAV 735
+MGA+A+
Sbjct: 675 FATKMGAKAM 684
>sp|P52034|K6PF_DROME 6-phosphofructokinase (Phosphofructokinase) (Phosphohexokinase)
Length = 788
Score = 369 bits (948), Expect = e-102
Identities = 184/281 (65%), Positives = 224/281 (79%)
Frame = +1
Query: 10 GGTVIGSARCMDFKTREGLLKAAKNLIDRNITNLVVIGGDGSLTGANYFRLEWNSLLKEL 189
GGT+IGSARC DF+ R+G LKAA NLI R ITNLVVIGGDGSLTGAN FR EW+SLL EL
Sbjct: 82 GGTIIGSARCQDFRERQGRLKAANNLIQRGITNLVVIGGDGSLTGANLFRQEWSSLLDEL 141
Query: 190 LEQNRITEDQRKKCGHLNIVGMVGSIDNDFCGTDMTIGTDSALHRIIEACDAITSTAQSH 369
++ IT +Q++K L+IVG+VGSIDNDFCGTDMTIGTD+ALHRIIEA DAI+STA SH
Sbjct: 142 VKNKTITTEQQEKFNVLHIVGLVGSIDNDFCGTDMTIGTDTALHRIIEAIDAISSTAYSH 201
Query: 370 QRCFIMEVMGRHCGYXXXXXXXXSEAEWVFIPEMPPGPNWENKLCQKLQINRDNGQRVNI 549
QR FIMEVMGRHCGY EA+++FIPEMPP +W ++LC +L R GQR+NI
Sbjct: 202 QRTFIMEVMGRHCGYLALVGGLACEADFIFIPEMPPKVDWPDRLCSQLAQERSAGQRLNI 261
Query: 550 ILVSEGAIDNNCNPITSDQIKNLIVSKLNIDTRVTVLGHVQRGGNPSAFDRILGIRMGAE 729
++V+EGA+D +PIT++ +K +I +L D R+TVLGHVQRGGNPSAFDRIL RMGAE
Sbjct: 262 VIVAEGAMDREGHPITAEDVKKVIDERLKHDARITVLGHVQRGGNPSAFDRILACRMGAE 321
Query: 730 AVLALMDADRNLNSEASVISIDGNQTVRVPLLKCVEKTRAV 852
A LALM+A + +S VIS+DGNQ VRVPL++CVE+T+AV
Sbjct: 322 ATLALMEATK--DSVPVVISLDGNQAVRVPLMECVERTQAV 360
Score = 80.9 bits (198), Expect = 4e-15
Identities = 80/295 (27%), Positives = 136/295 (46%), Gaps = 17/295 (5%)
Frame = +1
Query: 10 GGTVIGSARCMDFKTREGLLKA-AKNLIDRNITNLVVIGGDGSLTGANYFRLEWNSLLKE 186
GG +G+ R + EG K A L + I L++IGG S A +
Sbjct: 472 GGAYLGTKRTLP----EGKFKEIAARLKEFKIQGLLIIGGFESYHAAG-----------Q 516
Query: 187 LLEQNRITEDQRKKCGHLNIVGMVGSIDNDFCGTDMTIGTDSALHRIIEACDAITSTAQ- 363
+ +Q ++ + C + IV + +I N+ GT+ ++G D+ L+ I E CD I +AQ
Sbjct: 517 IADQR---DNYPQFC--IPIVVIPSTISNNVPGTEFSLGCDTGLNEITEICDRIRQSAQG 571
Query: 364 SHQRCFIMEVMGRHCGYXXXXXXXXSEAEWVFIPEMPPGPNWENKLCQKLQINRDNGQRV 543
+ +R F++E MG +CGY A+ +I E + + G
Sbjct: 572 TKRRVFVIETMGGYCGYLATLAGLAGGADAAYIYEEKFSIKDLQQDVYHMASKMAEGVSR 631
Query: 544 NIILVSEGAIDNNCNP----ITSDQIKNLIVSKLNIDTRVTVLGHVQRGGNPSAFDRILG 711
+IL +E A +N + S++ K L ++NI LGH+Q+GG+P+ FDR +G
Sbjct: 632 GLILRNEKASENYSTDFIYRLYSEEGKGLFTCRMNI------LGHMQQGGSPTPFDRNMG 685
Query: 712 IRMGAEAV-------LALMDADRNLNSE----ASVISIDGNQTVRVPLLKCVEKT 843
+M A+ V A +DA+ +N + A+++ I Q PL+ + +T
Sbjct: 686 TKMAAKCVDWLAAQIKANIDANGVVNCKSPDTATLLGIVSRQYRFSPLVDLIAET 740
>sp|Q60HD9|K6PF_MACFA 6-phosphofructokinase, muscle type (Phosphofructokinase 1)
(Phosphohexokinase) (Phosphofructo-1-kinase isozyme A)
(PFK-A) (Phosphofructokinase-M)
Length = 780
Score = 369 bits (948), Expect = e-102
Identities = 182/284 (64%), Positives = 221/284 (77%)
Frame = +1
Query: 1 MQLGGTVIGSARCMDFKTREGLLKAAKNLIDRNITNLVVIGGDGSLTGANYFRLEWNSLL 180
+QLGGTVIGSARC DF+ REG L+AA NL+ R ITNL VIGGDGSLTGA+ FR EW+ LL
Sbjct: 77 LQLGGTVIGSARCKDFREREGRLRAAYNLVKRGITNLCVIGGDGSLTGADTFRSEWSELL 136
Query: 181 KELLEQNRITEDQRKKCGHLNIVGMVGSIDNDFCGTDMTIGTDSALHRIIEACDAITSTA 360
+L + +IT+++ K +LNIVG+VGSIDNDFCGTDMTIGTDSALHRIIE DAIT+TA
Sbjct: 137 GDLQKAGKITDEEATKSSYLNIVGLVGSIDNDFCGTDMTIGTDSALHRIIEIVDAITTTA 196
Query: 361 QSHQRCFIMEVMGRHCGYXXXXXXXXSEAEWVFIPEMPPGPNWENKLCQKLQINRDNGQR 540
QSHQR F++EVMGRHCGY A+WVFIPE PP +WE LC++L R G R
Sbjct: 197 QSHQRTFVLEVMGRHCGYLALVTSLSCGADWVFIPECPPDDDWEEHLCRRLSETRTRGSR 256
Query: 541 VNIILVSEGAIDNNCNPITSDQIKNLIVSKLNIDTRVTVLGHVQRGGNPSAFDRILGIRM 720
+NII+V+EGAID N PITS+ IKNL+V +L DTRVTVLGHVQRGG PSAFDRILG RM
Sbjct: 257 LNIIIVAEGAIDRNGKPITSEDIKNLVVKRLGYDTRVTVLGHVQRGGTPSAFDRILGSRM 316
Query: 721 GAEAVLALMDADRNLNSEASVISIDGNQTVRVPLLKCVEKTRAV 852
G EAV+AL++ ++ A V+S+ GNQ VR+PL++CV+ T+ V
Sbjct: 317 GVEAVMALLEG--TPDTPACVVSLSGNQAVRLPLMECVQVTKDV 358
Score = 92.0 bits (227), Expect = 2e-18
Identities = 81/250 (32%), Positives = 123/250 (49%), Gaps = 8/250 (3%)
Frame = +1
Query: 10 GGTVIGSARCMDFKTREGLLKAAKNLIDRNITNLVVIGGDGSLTGANYFRLEWNSLLKEL 189
GG+ +G+ R + K+ E + + N+ NI LV+IGG + TG EL
Sbjct: 463 GGSKLGTKRTLPKKSFEQI---SANITKFNIQGLVIIGGFEAYTGG-----------LEL 508
Query: 190 LEQNRITEDQRKKCGHLNIVGMV--GSIDNDFCGTDMTIGTDSALHRIIEACDAIT-STA 360
+E RK+ L I +V ++ N+ G+D ++G D+AL+ I CD I S A
Sbjct: 509 MEG-------RKQFDELCIPFVVIPATVSNNVPGSDFSVGADTALNTICTTCDRIKQSAA 561
Query: 361 QSHQRCFIMEVMGRHCGYXXXXXXXXSEAEWVFIPEMPPGPNWENKLCQKLQINRDNGQR 540
+ +R FI+E MG +CGY + A+ +I E P + LQ N ++ +
Sbjct: 562 GTKRRVFIIETMGGYCGYLATMAGLAAGADAAYIFEEP-------FTIRDLQANVEHLVQ 614
Query: 541 VNIILVSEGAIDNN--CNP-ITSDQIKNLIVS--KLNIDTRVTVLGHVQRGGNPSAFDRI 705
V G + N CN T+D I NL K D+R VLGH+Q+GG+P+ FDR
Sbjct: 615 KMKTTVKRGLVLRNEKCNENYTTDFIFNLYSEEGKGIFDSRKNVLGHMQQGGSPTPFDRN 674
Query: 706 LGIRMGAEAV 735
+MGA+A+
Sbjct: 675 FATKMGAKAM 684
>sp|P08237|K6PF_HUMAN 6-phosphofructokinase, muscle type (Phosphofructokinase 1)
(Phosphohexokinase) (Phosphofructo-1-kinase isozyme A)
(PFK-A) (Phosphofructokinase-M)
Length = 780
Score = 369 bits (947), Expect = e-102
Identities = 181/284 (63%), Positives = 221/284 (77%)
Frame = +1
Query: 1 MQLGGTVIGSARCMDFKTREGLLKAAKNLIDRNITNLVVIGGDGSLTGANYFRLEWNSLL 180
+QLGGTVIGSARC DF+ REG L+AA NL+ R ITNL VIGGDGSLTGA+ FR EW+ LL
Sbjct: 77 LQLGGTVIGSARCKDFREREGRLRAAYNLVKRGITNLCVIGGDGSLTGADTFRSEWSDLL 136
Query: 181 KELLEQNRITEDQRKKCGHLNIVGMVGSIDNDFCGTDMTIGTDSALHRIIEACDAITSTA 360
+L + +IT+++ K +LNIVG+VGSIDNDFCGTDMTIGTDSALHRI+E DAIT+TA
Sbjct: 137 SDLQKAGKITDEEATKSSYLNIVGLVGSIDNDFCGTDMTIGTDSALHRIMEIVDAITTTA 196
Query: 361 QSHQRCFIMEVMGRHCGYXXXXXXXXSEAEWVFIPEMPPGPNWENKLCQKLQINRDNGQR 540
QSHQR F++EVMGRHCGY A+WVFIPE PP +WE LC++L R G R
Sbjct: 197 QSHQRTFVLEVMGRHCGYLALVTSLSCGADWVFIPECPPDDDWEEHLCRRLSETRTRGSR 256
Query: 541 VNIILVSEGAIDNNCNPITSDQIKNLIVSKLNIDTRVTVLGHVQRGGNPSAFDRILGIRM 720
+NII+V+EGAID N PITS+ IKNL+V +L DTRVTVLGHVQRGG PSAFDRILG RM
Sbjct: 257 LNIIIVAEGAIDKNGKPITSEDIKNLVVKRLGYDTRVTVLGHVQRGGTPSAFDRILGSRM 316
Query: 721 GAEAVLALMDADRNLNSEASVISIDGNQTVRVPLLKCVEKTRAV 852
G EAV+AL++ ++ A V+S+ GNQ VR+PL++CV+ T+ V
Sbjct: 317 GVEAVMALLEG--TPDTPACVVSLSGNQAVRLPLMECVQVTKDV 358
Score = 92.0 bits (227), Expect = 2e-18
Identities = 81/250 (32%), Positives = 123/250 (49%), Gaps = 8/250 (3%)
Frame = +1
Query: 10 GGTVIGSARCMDFKTREGLLKAAKNLIDRNITNLVVIGGDGSLTGANYFRLEWNSLLKEL 189
GG+ +G+ R + K+ E + + N+ NI LV+IGG + TG EL
Sbjct: 463 GGSKLGTKRTLPKKSFEQI---SANITKFNIQGLVIIGGFEAYTGG-----------LEL 508
Query: 190 LEQNRITEDQRKKCGHLNIVGMV--GSIDNDFCGTDMTIGTDSALHRIIEACDAIT-STA 360
+E RK+ L I +V ++ N+ G+D ++G D+AL+ I CD I S A
Sbjct: 509 MEG-------RKQFDELCIPFVVIPATVSNNVPGSDFSVGADTALNTICTTCDRIKQSAA 561
Query: 361 QSHQRCFIMEVMGRHCGYXXXXXXXXSEAEWVFIPEMPPGPNWENKLCQKLQINRDNGQR 540
+ +R FI+E MG +CGY + A+ +I E P + LQ N ++ +
Sbjct: 562 GTKRRVFIIETMGGYCGYLATMAGLAAGADAAYIFEEP-------FTIRDLQANVEHLVQ 614
Query: 541 VNIILVSEGAIDNN--CNP-ITSDQIKNLIVS--KLNIDTRVTVLGHVQRGGNPSAFDRI 705
V G + N CN T+D I NL K D+R VLGH+Q+GG+P+ FDR
Sbjct: 615 KMKTTVKRGLVLRNEKCNENYTTDFIFNLYSEEGKGIFDSRKNVLGHMQQGGSPTPFDRN 674
Query: 706 LGIRMGAEAV 735
+MGA+A+
Sbjct: 675 FATKMGAKAM 684
>sp|P52784|K6PF_CANFA 6-phosphofructokinase, muscle type (Phosphofructokinase 1)
(Phosphohexokinase) (Phosphofructo-1-kinase isozyme A)
(PFK-A) (Phosphofructokinase-M)
Length = 782
Score = 368 bits (944), Expect = e-101
Identities = 181/284 (63%), Positives = 220/284 (77%)
Frame = +1
Query: 1 MQLGGTVIGSARCMDFKTREGLLKAAKNLIDRNITNLVVIGGDGSLTGANYFRLEWNSLL 180
+QLGGTVIGSARC DF+ REG L+AA NL+ R ITNL VIGGDGSLTGA+ FR EW+ LL
Sbjct: 77 LQLGGTVIGSARCKDFREREGRLRAAHNLVKRGITNLCVIGGDGSLTGADTFRSEWSDLL 136
Query: 181 KELLEQNRITEDQRKKCGHLNIVGMVGSIDNDFCGTDMTIGTDSALHRIIEACDAITSTA 360
+L + +IT ++ K +LNIVG+VGSIDNDFCGTDMTIGTDSALHRIIE DAIT+TA
Sbjct: 137 SDLQKAGKITAEEATKSSYLNIVGLVGSIDNDFCGTDMTIGTDSALHRIIEIVDAITTTA 196
Query: 361 QSHQRCFIMEVMGRHCGYXXXXXXXXSEAEWVFIPEMPPGPNWENKLCQKLQINRDNGQR 540
QSHQR F++EVMGRHCGY A+WVFIPE PP +WE LC++L R G R
Sbjct: 197 QSHQRTFVLEVMGRHCGYLALVTSLSCGADWVFIPECPPDDDWEEHLCRRLSETRTRGSR 256
Query: 541 VNIILVSEGAIDNNCNPITSDQIKNLIVSKLNIDTRVTVLGHVQRGGNPSAFDRILGIRM 720
+NII+V+EGAID N PITS++IK L+V +L DTRVTVLGHVQRGG PSAFDRILG RM
Sbjct: 257 LNIIIVAEGAIDKNGKPITSEEIKELVVKRLGYDTRVTVLGHVQRGGTPSAFDRILGSRM 316
Query: 721 GAEAVLALMDADRNLNSEASVISIDGNQTVRVPLLKCVEKTRAV 852
G EAV+AL++ ++ A V+S+ GNQ VR+PL++CV+ T+ V
Sbjct: 317 GVEAVMALLEG--TPDTPACVVSLSGNQAVRLPLMECVQVTKDV 358
Score = 91.7 bits (226), Expect = 2e-18
Identities = 80/250 (32%), Positives = 123/250 (49%), Gaps = 8/250 (3%)
Frame = +1
Query: 10 GGTVIGSARCMDFKTREGLLKAAKNLIDRNITNLVVIGGDGSLTGANYFRLEWNSLLKEL 189
GG+ +G+ R + K+ E + + N+ NI L++IGG + TG EL
Sbjct: 465 GGSKLGTKRTLPKKSFEQI---SANITKFNIQGLIIIGGFEAYTGG-----------LEL 510
Query: 190 LEQNRITEDQRKKCGHLNIVGMV--GSIDNDFCGTDMTIGTDSALHRIIEACDAIT-STA 360
+E RK+ L I +V ++ N+ G+D ++G D+AL+ I CD I S A
Sbjct: 511 MEG-------RKQFDELCIPFVVIPATVSNNVPGSDFSVGADTALNTICTTCDRIKQSAA 563
Query: 361 QSHQRCFIMEVMGRHCGYXXXXXXXXSEAEWVFIPEMPPGPNWENKLCQKLQINRDNGQR 540
+ +R FI+E MG +CGY + A+ +I E P + LQ N ++ +
Sbjct: 564 GTKRRVFIIETMGGYCGYLATMAGLAAGADAAYIFEEP-------FTIRDLQANVEHLVQ 616
Query: 541 VNIILVSEGAIDNN--CNP-ITSDQIKNLIVS--KLNIDTRVTVLGHVQRGGNPSAFDRI 705
V G + N CN T+D I NL K D+R VLGH+Q+GG+P+ FDR
Sbjct: 617 KMKTTVKRGLVLRNEKCNENYTTDFIFNLYSEEGKGIFDSRKNVLGHMQQGGSPTPFDRN 676
Query: 706 LGIRMGAEAV 735
+MGA+A+
Sbjct: 677 FATKMGAKAM 686
>sp|Q867C9|K6PF_HORSE 6-phosphofructokinase, muscle type (Phosphofructokinase 1)
(Phosphohexokinase) (Phosphofructo-1-kinase isozyme A)
(PFK-A) (Phosphofructokinase-M)
Length = 780
Score = 367 bits (941), Expect = e-101
Identities = 181/284 (63%), Positives = 221/284 (77%)
Frame = +1
Query: 1 MQLGGTVIGSARCMDFKTREGLLKAAKNLIDRNITNLVVIGGDGSLTGANYFRLEWNSLL 180
+QLGGTVIGSARC DF+ REG L+AA NL+ ITNL VIGGDGSLTGA+ FR EW+ LL
Sbjct: 77 LQLGGTVIGSARCKDFREREGRLRAAHNLVKLGITNLCVIGGDGSLTGADTFRSEWSDLL 136
Query: 181 KELLEQNRITEDQRKKCGHLNIVGMVGSIDNDFCGTDMTIGTDSALHRIIEACDAITSTA 360
+L + +IT ++ K +LNIVG+VGSIDNDFCGTDMTIGTDSALHRIIE DAIT+TA
Sbjct: 137 SDLQKAGKITAEEATKSNYLNIVGLVGSIDNDFCGTDMTIGTDSALHRIIEIVDAITTTA 196
Query: 361 QSHQRCFIMEVMGRHCGYXXXXXXXXSEAEWVFIPEMPPGPNWENKLCQKLQINRDNGQR 540
QSHQR F++EVMGRHCGY A+WVFIPE PP +WE+ LC++L R G R
Sbjct: 197 QSHQRTFVLEVMGRHCGYLALVTSLSCGADWVFIPECPPDDDWEDHLCRRLSETRTRGSR 256
Query: 541 VNIILVSEGAIDNNCNPITSDQIKNLIVSKLNIDTRVTVLGHVQRGGNPSAFDRILGIRM 720
+NII+V+EGAID N PITS+ IK+L+V +L DTRVTVLGHVQRGG PSAFDRILG RM
Sbjct: 257 LNIIIVAEGAIDRNGKPITSESIKDLVVKRLGYDTRVTVLGHVQRGGTPSAFDRILGSRM 316
Query: 721 GAEAVLALMDADRNLNSEASVISIDGNQTVRVPLLKCVEKTRAV 852
G EAV+AL++A ++ A V+S+ GNQ VR+PL++CV+ T+ V
Sbjct: 317 GVEAVMALLEA--TPDTPACVVSLSGNQAVRLPLMECVQVTKDV 358
Score = 90.9 bits (224), Expect = 4e-18
Identities = 78/250 (31%), Positives = 124/250 (49%), Gaps = 8/250 (3%)
Frame = +1
Query: 10 GGTVIGSARCMDFKTREGLLKAAKNLIDRNITNLVVIGGDGSLTGANYFRLEWNSLLKEL 189
GG+ +G+ R + K+ E + + N+ NI L+++GG + TG EL
Sbjct: 463 GGSKLGTKRTLPRKSFEQI---SANITKFNIQGLIIVGGFEAYTGG-----------LEL 508
Query: 190 LEQNRITEDQRKKCGHLNIVGMV--GSIDNDFCGTDMTIGTDSALHRIIEACDAIT-STA 360
+E RK+ L I +V ++ N+ G+D ++G D+AL+ I CD I S A
Sbjct: 509 MEG-------RKQYDELCIPFVVIPATVSNNVPGSDFSVGADTALNTICMTCDRIKQSAA 561
Query: 361 QSHQRCFIMEVMGRHCGYXXXXXXXXSEAEWVFIPEMPPGPNWENKLCQKLQINRDNGQR 540
+ +R FI+E MG +CGY + A+ +I E P + LQ+N ++ +
Sbjct: 562 GTKRRVFIIETMGGYCGYLATMAGLAAGADAAYIFEEP-------FTIRDLQVNVEHLVQ 614
Query: 541 VNIILVSEGAIDNN--CNP-ITSDQIKNLIVS--KLNIDTRVTVLGHVQRGGNPSAFDRI 705
V G + N CN ++D I NL K D+R VLGH+Q+GG+P+ FDR
Sbjct: 615 KMKTTVKRGLVLRNEKCNENYSTDFIFNLYSEEGKGIFDSRKNVLGHMQQGGSPTPFDRN 674
Query: 706 LGIRMGAEAV 735
+MGA+A+
Sbjct: 675 FATKMGAKAM 684
>sp|P47858|K6PF_RAT 6-phosphofructokinase, muscle type (Phosphofructokinase 1)
(Phosphohexokinase) (Phosphofructo-1-kinase isozyme A)
(PFK-A) (Phosphofructokinase-M)
Length = 780
Score = 366 bits (939), Expect = e-101
Identities = 180/284 (63%), Positives = 219/284 (77%)
Frame = +1
Query: 1 MQLGGTVIGSARCMDFKTREGLLKAAKNLIDRNITNLVVIGGDGSLTGANYFRLEWNSLL 180
+QLGGTVIGSARC DF+ REG L+AA NL+ R ITNL VIGGDGSLTGA+ FR EW+ LL
Sbjct: 77 LQLGGTVIGSARCKDFREREGRLRAAHNLVKRGITNLCVIGGDGSLTGADTFRSEWSDLL 136
Query: 181 KELLEQNRITEDQRKKCGHLNIVGMVGSIDNDFCGTDMTIGTDSALHRIIEACDAITSTA 360
+L + +IT ++R K +LNIV +VGSIDNDFCGTDMTIGTDSALHRI+E DAIT+TA
Sbjct: 137 NDLQKDGKITAEERTKSSYLNIVFLVGSIDNDFCGTDMTIGTDSALHRIVEIVDAITTTA 196
Query: 361 QSHQRCFIMEVMGRHCGYXXXXXXXXSEAEWVFIPEMPPGPNWENKLCQKLQINRDNGQR 540
QSHQR F++EVMGRHCGY A+WVFIPE PP +WE LC++L R G R
Sbjct: 197 QSHQRTFVLEVMGRHCGYLALVTSLSCGADWVFIPECPPDDDWEEHLCRRLSETRTRGSR 256
Query: 541 VNIILVSEGAIDNNCNPITSDQIKNLIVSKLNIDTRVTVLGHVQRGGNPSAFDRILGIRM 720
+NII+V+EGAID N PITS+ IKNL+V +L DTRVTVLGHVQRGG PSAFDRILG RM
Sbjct: 257 LNIIIVAEGAIDKNGKPITSEDIKNLVVKRLGYDTRVTVLGHVQRGGTPSAFDRILGSRM 316
Query: 721 GAEAVLALMDADRNLNSEASVISIDGNQTVRVPLLKCVEKTRAV 852
G EAV+AL++ ++ A V+S+ GN VR+PL++CV+ T+ V
Sbjct: 317 GVEAVMALLEG--TPDTPACVVSLSGNTAVRLPLMECVQVTKDV 358
Score = 95.9 bits (237), Expect = 1e-19
Identities = 83/249 (33%), Positives = 122/249 (48%), Gaps = 8/249 (3%)
Frame = +1
Query: 10 GGTVIGSARCMDFKTREGLLKAAKNLIDRNITNLVVIGGDGSLTGANYFRLEWNSLLKEL 189
GG+ +G+ R + K E + + N+ NI LV+IGG + TG EL
Sbjct: 463 GGSKLGTKRTLPKKNLEQI---SANITKYNIQGLVIIGGFEAYTGG-----------LEL 508
Query: 190 LEQNRITEDQRKKCGHLNIVGMV--GSIDNDFCGTDMTIGTDSALHRIIEACDAIT-STA 360
+E RK+ L I +V ++ N+ G+D +IG D+AL+ I CD I S A
Sbjct: 509 MEG-------RKQFDELCIPFVVIPATVSNNVPGSDFSIGADTALNTICTTCDRIKQSAA 561
Query: 361 QSHQRCFIMEVMGRHCGYXXXXXXXXSEAEWVFIPEMPPGPNWENKLCQKLQINRDNGQR 540
+ +R FI+E MG +CGY + A+ +I E P + LQ+N ++ +
Sbjct: 562 GTKRRVFIIETMGGYCGYLATMAGLAAGADAAYIFEEP-------FTIRDLQVNVEHLVQ 614
Query: 541 VNIILVSEGAIDNN--CNP-ITSDQIKNLIVS--KLNIDTRVTVLGHVQRGGNPSAFDRI 705
V G + N CN T+D I NL K D+R VLGH+Q+GGNP+ FDR
Sbjct: 615 KMKTTVKRGLVLRNEKCNENYTTDFIFNLYSEEGKGIFDSRKNVLGHMQQGGNPTPFDRN 674
Query: 706 LGIRMGAEA 732
+MGA+A
Sbjct: 675 FATKMGAKA 683
>sp|P00511|K6PF_RABIT 6-phosphofructokinase, muscle type (Phosphofructokinase 1)
(Phosphohexokinase) (Phosphofructo-1-kinase isozyme A)
(PFK-A) (Phosphofructokinase-M)
Length = 780
Score = 365 bits (937), Expect = e-101
Identities = 179/284 (63%), Positives = 220/284 (77%)
Frame = +1
Query: 1 MQLGGTVIGSARCMDFKTREGLLKAAKNLIDRNITNLVVIGGDGSLTGANYFRLEWNSLL 180
+QLGGTVIGSARC DF+ REG L+AA NL+ R ITNL VIGGDGSLTGA+ FR EW+ LL
Sbjct: 77 LQLGGTVIGSARCKDFREREGRLRAAHNLVKRGITNLCVIGGDGSLTGADTFRSEWSDLL 136
Query: 181 KELLEQNRITEDQRKKCGHLNIVGMVGSIDNDFCGTDMTIGTDSALHRIIEACDAITSTA 360
+L + +IT ++ + +LNIVG+VGSIDNDFCGTDMTIGTDSALHRI E DAIT+TA
Sbjct: 137 SDLQKAGKITAEEATRSSYLNIVGLVGSIDNDFCGTDMTIGTDSALHRITEIVDAITTTA 196
Query: 361 QSHQRCFIMEVMGRHCGYXXXXXXXXSEAEWVFIPEMPPGPNWENKLCQKLQINRDNGQR 540
QSHQR F++EVMGRHCGY A+WVFIPE PP NWE+ LC++L R G R
Sbjct: 197 QSHQRTFVLEVMGRHCGYLALVTSLSCGADWVFIPECPPDDNWEDHLCRRLSETRTRGSR 256
Query: 541 VNIILVSEGAIDNNCNPITSDQIKNLIVSKLNIDTRVTVLGHVQRGGNPSAFDRILGIRM 720
+NII+V+EGAID N PITS+ +K+L+V +L DTRVTVLGHVQRGG PSAFDRILG RM
Sbjct: 257 LNIIIVAEGAIDRNGKPITSEGVKDLVVRRLGYDTRVTVLGHVQRGGTPSAFDRILGSRM 316
Query: 721 GAEAVLALMDADRNLNSEASVISIDGNQTVRVPLLKCVEKTRAV 852
G EAV+AL++ ++ A V+S+ GNQ VR+PL++CV+ T+ V
Sbjct: 317 GVEAVMALLEG--TPDTPACVVSLSGNQAVRLPLMECVQVTKDV 358
Score = 93.2 bits (230), Expect = 8e-19
Identities = 82/250 (32%), Positives = 123/250 (49%), Gaps = 8/250 (3%)
Frame = +1
Query: 10 GGTVIGSARCMDFKTREGLLKAAKNLIDRNITNLVVIGGDGSLTGANYFRLEWNSLLKEL 189
GG+ +GS R + K+ E + + N+ NI LV+IGG + TG EL
Sbjct: 463 GGSKLGSKRTLPKKSFEQI---SANITKFNIQGLVIIGGFEAYTGG-----------LEL 508
Query: 190 LEQNRITEDQRKKCGHLNIVGMV--GSIDNDFCGTDMTIGTDSALHRIIEACDAIT-STA 360
+E RK+ L I +V ++ N+ G+D ++G D+AL+ I CD I S A
Sbjct: 509 MEG-------RKQFDELCIPFVVIPATVSNNVPGSDFSVGADTALNTICTTCDRIKQSAA 561
Query: 361 QSHQRCFIMEVMGRHCGYXXXXXXXXSEAEWVFIPEMPPGPNWENKLCQKLQINRDNGQR 540
+ +R FI+E MG +CGY + A+ +I E P + LQ N ++ +
Sbjct: 562 GTKRRVFIIETMGGYCGYLATMAGLAAGADAAYIFEEP-------FTIRDLQANVEHLVQ 614
Query: 541 VNIILVSEGAIDNN--CNP-ITSDQIKNLIVS--KLNIDTRVTVLGHVQRGGNPSAFDRI 705
V G + N CN T+D I NL K D+R VLGH+Q+GG+P+ FDR
Sbjct: 615 KMKTTVKRGLVLRNEKCNENYTTDFIFNLYSEEGKGIFDSRKNVLGHMQQGGSPTPFDRN 674
Query: 706 LGIRMGAEAV 735
+MGA+A+
Sbjct: 675 FATKMGAKAM 684
>sp|Q01813|K6PP_HUMAN 6-phosphofructokinase type C (Phosphofructokinase 1)
(Phosphohexokinase) (Phosphofructo-1-kinase isozyme C)
(PFK-C) (6-phosphofructokinase, platelet type)
Length = 784
Score = 358 bits (919), Expect = 1e-98
Identities = 176/284 (61%), Positives = 219/284 (77%)
Frame = +1
Query: 1 MQLGGTVIGSARCMDFKTREGLLKAAKNLIDRNITNLVVIGGDGSLTGANYFRLEWNSLL 180
+Q+GGT+IGSARC F+TREG LKAA NL+ R ITNL VIGGDGSLTGAN FR EW+ LL
Sbjct: 86 LQVGGTIIGSARCQAFRTREGRLKAACNLLQRGITNLCVIGGDGSLTGANLFRKEWSGLL 145
Query: 181 KELLEQNRITEDQRKKCGHLNIVGMVGSIDNDFCGTDMTIGTDSALHRIIEACDAITSTA 360
+EL +I ++ +K +LN+VGMVGSIDNDFCGTDMTIGTDSALHRIIE DAI +TA
Sbjct: 146 EELARNGQIDKEAVQKYAYLNVVGMVGSIDNDFCGTDMTIGTDSALHRIIEVVDAIMTTA 205
Query: 361 QSHQRCFIMEVMGRHCGYXXXXXXXXSEAEWVFIPEMPPGPNWENKLCQKLQINRDNGQR 540
QSHQR F++EVMGRHCGY A+WVF+PE PP WE ++C KL NR +R
Sbjct: 206 QSHQRTFVLEVMGRHCGYLALVSALACGADWVFLPESPPEEGWEEQMCVKLSENRARKKR 265
Query: 541 VNIILVSEGAIDNNCNPITSDQIKNLIVSKLNIDTRVTVLGHVQRGGNPSAFDRILGIRM 720
+NII+V+EGAID PITS++IK L+V++L DTRVT+LGHVQRGG PSAFDRIL RM
Sbjct: 266 LNIIIVAEGAIDTQNKPITSEKIKELVVTQLGYDTRVTILGHVQRGGTPSAFDRILASRM 325
Query: 721 GAEAVLALMDADRNLNSEASVISIDGNQTVRVPLLKCVEKTRAV 852
G EAV+AL++A ++ A V+S++GN VR+PL++CV+ T+ V
Sbjct: 326 GVEAVIALLEA--TPDTPACVVSLNGNHAVRLPLMECVQMTQDV 367
Score = 86.3 bits (212), Expect = 1e-16
Identities = 75/250 (30%), Positives = 121/250 (48%), Gaps = 8/250 (3%)
Frame = +1
Query: 10 GGTVIGSARCMDFKTREGLLKAAKNLIDRNITNLVVIGGDGSLTGANYFRLEWNSLLKEL 189
GG+++G+ R + K E + A + +I L++IGG + G L
Sbjct: 473 GGSILGTKRVLPGKYLEEI---ATQMRTHSINALLIIGGFEAYLG--------------L 515
Query: 190 LEQNRITEDQRKKCGHLNIVGMVGSIDNDFCGTDMTIGTDSALHRIIEACDAITSTAQ-S 366
LE + E + C + +V + ++ N+ G+D +IG D+AL+ I + CD I +A +
Sbjct: 516 LELSAAREKHEEFC--VPMVMVPATVSNNVPGSDFSIGADTALNTITDTCDRIKQSASGT 573
Query: 367 HQRCFIMEVMGRHCGYXXXXXXXXSEAEWVFIPEMPPG-----PNWENKLCQKLQINRDN 531
+R FI+E MG +CGY + A+ +I E P N E+ L +K++
Sbjct: 574 KRRVFIIETMGGYCGYLANMGGLAAGADAAYIFEEPFDIRDLQSNVEH-LTEKMKTTIQR 632
Query: 532 GQRVNIILVSEGAIDNNCNPITSDQIKNLIVS--KLNIDTRVTVLGHVQRGGNPSAFDRI 705
G ++L +E +N T+D I L K D R VLGH+Q+GG PS FDR
Sbjct: 633 G----LVLRNESCSEN----YTTDFIYQLYSEEGKGVFDCRKNVLGHMQQGGAPSPFDRN 684
Query: 706 LGIRMGAEAV 735
G ++ A A+
Sbjct: 685 FGTKISARAM 694
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 97,821,966
Number of Sequences: 369166
Number of extensions: 1909984
Number of successful extensions: 5182
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 4770
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 4958
length of database: 68,354,980
effective HSP length: 109
effective length of database: 48,218,865
effective search space used: 8438301375
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)