Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_026_O18
(446 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P25782|CYSP2_HOMAM Digestive cysteine proteinase 2 precu... 139 3e-33
sp|O60911|CATL2_HUMAN Cathepsin L2 precursor (Cathepsin V) ... 138 6e-33
sp|P25975|CATL_BOVIN Cathepsin L precursor [Contains: Cathe... 135 3e-32
sp|Q28944|CATL_PIG Cathepsin L precursor [Contains: Catheps... 134 7e-32
sp|P06797|CATL_MOUSE Cathepsin L precursor (Major excreted ... 133 2e-31
sp|P43236|CATK_RABIT Cathepsin K precursor (OC-2 protein) 132 3e-31
sp|P07711|CATL_HUMAN Cathepsin L precursor (Major excreted ... 132 3e-31
sp|P07154|CATL_RAT Cathepsin L precursor (Major excreted pr... 132 3e-31
sp|P43235|CATK_HUMAN Cathepsin K precursor (Cathepsin O) (C... 132 5e-31
sp|O35186|CATK_RAT Cathepsin K precursor 132 5e-31
>sp|P25782|CYSP2_HOMAM Digestive cysteine proteinase 2 precursor
Length = 323
Score = 139 bits (350), Expect = 3e-33
Identities = 67/115 (58%), Positives = 79/115 (68%), Gaps = 1/115 (0%)
Frame = +2
Query: 14 SKVVANCKGFQNINSCNEKDLAVAVATVGPISVAIDVGYS-FQQYKQGVYYEAKCDPTIQ 190
+ V A C G NI S +E L AV +GPISV ID +S FQ Y GVYYE C P+
Sbjct: 209 NSVAATCSGHTNIASGSETGLQQAVRDIGPISVTIDAAHSSFQFYSSGVYYEPSCSPSYL 268
Query: 191 NHAVLVVGYGVENGHKYWLVKNSWGPSWGMNGYIKMSKDRDNNCGIATTASFPIV 355
+HAVL VGYG E G +WLVKNSW SWG GYIKMS++R+NNCGIAT AS+P+V
Sbjct: 269 DHAVLAVGYGSEGGQDFWLVKNSWATSWGDAGYIKMSRNRNNNCGIATVASYPLV 323
>sp|O60911|CATL2_HUMAN Cathepsin L2 precursor (Cathepsin V) (Cathepsin U)
Length = 334
Score = 138 bits (347), Expect = 6e-33
Identities = 70/121 (57%), Positives = 83/121 (68%), Gaps = 5/121 (4%)
Frame = +2
Query: 8 RGSKVVANCKGFQNINSCNEKDLAVAVATVGPISVAIDVGYS-FQQYKQGVYYEAKCDPT 184
R VAN GF + EK L AVATVGPISVA+D G+S FQ YK G+Y+E C
Sbjct: 214 RPENSVANDTGFTVVAPGKEKALMKAVATVGPISVAMDAGHSSFQFYKSGIYFEPDCSSK 273
Query: 185 IQNHAVLVVGYGVE----NGHKYWLVKNSWGPSWGMNGYIKMSKDRDNNCGIATTASFPI 352
+H VLVVGYG E N KYWLVKNSWGP WG NGY+K++KD++N+CGIAT AS+P
Sbjct: 274 NLDHGVLVVGYGFEGANSNNSKYWLVKNSWGPEWGSNGYVKIAKDKNNHCGIATAASYPN 333
Query: 353 V 355
V
Sbjct: 334 V 334
>sp|P25975|CATL_BOVIN Cathepsin L precursor [Contains: Cathepsin L heavy chain; Cathepsin
L light chain]
Length = 334
Score = 135 bits (341), Expect = 3e-32
Identities = 69/115 (60%), Positives = 83/115 (72%), Gaps = 5/115 (4%)
Frame = +2
Query: 26 ANCKGFQNINSCNEKDLAVAVATVGPISVAIDVGY-SFQQYKQGVYYEAKCDPTIQNHAV 202
AN GF +I EK L AVATVGPISVAID G+ SFQ YK G+YY+ C +H V
Sbjct: 221 ANDTGFVDIPQ-REKALMKAVATVGPISVAIDAGHTSFQFYKSGIYYDPDCSCKDLDHGV 279
Query: 203 LVVGYGVE----NGHKYWLVKNSWGPSWGMNGYIKMSKDRDNNCGIATTASFPIV 355
LVVGYG E N +K+W+VKNSWGP WG NGY+KM+KD++N+CGIAT AS+P V
Sbjct: 280 LVVGYGFEGTDSNNNKFWIVKNSWGPEWGWNGYVKMAKDQNNHCGIATAASYPTV 334
>sp|Q28944|CATL_PIG Cathepsin L precursor [Contains: Cathepsin L heavy chain; Cathepsin
L light chain]
Length = 334
Score = 134 bits (338), Expect = 7e-32
Identities = 68/115 (59%), Positives = 82/115 (71%), Gaps = 5/115 (4%)
Frame = +2
Query: 26 ANCKGFQNINSCNEKDLAVAVATVGPISVAIDVGYS-FQQYKQGVYYEAKCDPTIQNHAV 202
AN GF +I EK L AVATVGPISVAID G+S FQ YK G+YY+ C +H V
Sbjct: 221 ANDTGFVDIPQ-REKALMKAVATVGPISVAIDAGHSSFQFYKSGIYYDPDCSSKDLDHGV 279
Query: 203 LVVGYGVE----NGHKYWLVKNSWGPSWGMNGYIKMSKDRDNNCGIATTASFPIV 355
LVVGYG E N K+W+VKNSWGP WG NGY+KM+KD++N+CGI+T AS+P V
Sbjct: 280 LVVGYGFEGTDSNSSKFWIVKNSWGPEWGWNGYVKMAKDQNNHCGISTAASYPTV 334
>sp|P06797|CATL_MOUSE Cathepsin L precursor (Major excreted protein) (MEP) (p39 cysteine
proteinase) [Contains: Cathepsin L heavy chain;
Cathepsin L light chain]
Length = 334
Score = 133 bits (334), Expect = 2e-31
Identities = 69/121 (57%), Positives = 82/121 (67%), Gaps = 5/121 (4%)
Frame = +2
Query: 8 RGSKVVANCKGFQNINSCNEKDLAVAVATVGPISVAIDVGY-SFQQYKQGVYYEAKCDPT 184
R VAN GF +I EK L AVATVGPISVA+D + S Q Y G+YYE C
Sbjct: 214 RAEFAVANDTGFVDIPQ-QEKALMKAVATVGPISVAMDASHPSLQFYSSGIYYEPNCSSK 272
Query: 185 IQNHAVLVVGYGVE----NGHKYWLVKNSWGPSWGMNGYIKMSKDRDNNCGIATTASFPI 352
+H VL+VGYG E N +KYWLVKNSWG WGM GYIK++KDRDN+CG+AT AS+P+
Sbjct: 273 NLDHGVLLVGYGYEGTDSNKNKYWLVKNSWGSEWGMEGYIKIAKDRDNHCGLATAASYPV 332
Query: 353 V 355
V
Sbjct: 333 V 333
>sp|P43236|CATK_RABIT Cathepsin K precursor (OC-2 protein)
Length = 329
Score = 132 bits (333), Expect = 3e-31
Identities = 61/109 (55%), Positives = 78/109 (71%), Gaps = 1/109 (0%)
Frame = +2
Query: 26 ANCKGFQNINSCNEKDLAVAVATVGPISVAIDVGY-SFQQYKQGVYYEAKCDPTIQNHAV 202
A C+G++ I NEK L AVA VGP+SVAID SFQ Y +GVYY+ C NHAV
Sbjct: 219 AKCRGYREIPEGNEKALKRAVARVGPVSVAIDASLTSFQFYSKGVYYDENCSSDNVNHAV 278
Query: 203 LVVGYGVENGHKYWLVKNSWGPSWGMNGYIKMSKDRDNNCGIATTASFP 349
L VGYG++ G+K+W++KNSWG SWG GYI M+++++N CGIA ASFP
Sbjct: 279 LAVGYGIQKGNKHWIIKNSWGESWGNKGYILMARNKNNACGIANLASFP 327
>sp|P07711|CATL_HUMAN Cathepsin L precursor (Major excreted protein) (MEP) [Contains:
Cathepsin L heavy chain; Cathepsin L light chain]
Length = 333
Score = 132 bits (333), Expect = 3e-31
Identities = 69/116 (59%), Positives = 82/116 (70%), Gaps = 5/116 (4%)
Frame = +2
Query: 23 VANCKGFQNINSCNEKDLAVAVATVGPISVAIDVGY-SFQQYKQGVYYEAKCDPTIQNHA 199
VAN GF +I EK L AVATVGPISVAID G+ SF YK+G+Y+E C +H
Sbjct: 219 VANDTGFVDIPK-QEKALMKAVATVGPISVAIDAGHESFLFYKEGIYFEPDCSSEDMDHG 277
Query: 200 VLVVGYGVEN----GHKYWLVKNSWGPSWGMNGYIKMSKDRDNNCGIATTASFPIV 355
VLVVGYG E+ +KYWLVKNSWG WGM GY+KM+KDR N+CGIA+ AS+P V
Sbjct: 278 VLVVGYGFESTESDNNKYWLVKNSWGEEWGMGGYVKMAKDRRNHCGIASAASYPTV 333
>sp|P07154|CATL_RAT Cathepsin L precursor (Major excreted protein) (MEP) (Cyclic
protein 2) (CP-2) [Contains: Cathepsin L heavy chain;
Cathepsin L light chain]
Length = 334
Score = 132 bits (333), Expect = 3e-31
Identities = 70/121 (57%), Positives = 82/121 (67%), Gaps = 5/121 (4%)
Frame = +2
Query: 8 RGSKVVANCKGFQNINSCNEKDLAVAVATVGPISVAIDVGY-SFQQYKQGVYYEAKCDPT 184
R VAN GF +I EK L AVATVGPISVA+D + S Q Y G+YYE C
Sbjct: 214 RAEYAVANDTGFVDIPQ-QEKALMKAVATVGPISVAMDASHPSLQFYSSGIYYEPNCSSK 272
Query: 185 IQNHAVLVVGYGVE----NGHKYWLVKNSWGPSWGMNGYIKMSKDRDNNCGIATTASFPI 352
+H VLVVGYG E N KYWLVKNSWG WGM+GYIK++KDR+N+CG+AT AS+PI
Sbjct: 273 DLDHGVLVVGYGYEGTDSNKDKYWLVKNSWGKEWGMDGYIKIAKDRNNHCGLATAASYPI 332
Query: 353 V 355
V
Sbjct: 333 V 333
>sp|P43235|CATK_HUMAN Cathepsin K precursor (Cathepsin O) (Cathepsin X) (Cathepsin O2)
Length = 329
Score = 132 bits (331), Expect = 5e-31
Identities = 60/109 (55%), Positives = 79/109 (72%), Gaps = 1/109 (0%)
Frame = +2
Query: 26 ANCKGFQNINSCNEKDLAVAVATVGPISVAIDVGY-SFQQYKQGVYYEAKCDPTIQNHAV 202
A C+G++ I NEK L AVA VGP+SVAID SFQ Y +GVYY+ C+ NHAV
Sbjct: 219 AKCRGYREIPEGNEKALKRAVARVGPVSVAIDASLTSFQFYSKGVYYDESCNSDNLNHAV 278
Query: 203 LVVGYGVENGHKYWLVKNSWGPSWGMNGYIKMSKDRDNNCGIATTASFP 349
L VGYG++ G+K+W++KNSWG +WG GYI M+++++N CGIA ASFP
Sbjct: 279 LAVGYGIQKGNKHWIIKNSWGENWGNKGYILMARNKNNACGIANLASFP 327
>sp|O35186|CATK_RAT Cathepsin K precursor
Length = 329
Score = 132 bits (331), Expect = 5e-31
Identities = 60/109 (55%), Positives = 78/109 (71%), Gaps = 1/109 (0%)
Frame = +2
Query: 26 ANCKGFQNINSCNEKDLAVAVATVGPISVAIDVGY-SFQQYKQGVYYEAKCDPTIQNHAV 202
A C+G++ I NEK L AVA VGP+SV+ID SFQ Y +GVYY+ CD NHAV
Sbjct: 219 AKCRGYREIPVGNEKALKRAVARVGPVSVSIDASLTSFQFYSRGVYYDENCDRDNVNHAV 278
Query: 203 LVVGYGVENGHKYWLVKNSWGPSWGMNGYIKMSKDRDNNCGIATTASFP 349
LVVGYG + G+KYW++KNSWG SWG GY+ ++++++N CGI ASFP
Sbjct: 279 LVVGYGTQKGNKYWIIKNSWGESWGNKGYVLLARNKNNACGITNLASFP 327
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 51,720,766
Number of Sequences: 369166
Number of extensions: 1022432
Number of successful extensions: 2908
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 2614
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 2701
length of database: 68,354,980
effective HSP length: 100
effective length of database: 49,881,480
effective search space used: 2394311040
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)