Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_026_N19
(831 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q9C040|TRIM2_HUMAN Tripartite motif protein 2 (RING fing... 39 0.018
sp|Q9ESN6|TRIM2_MOUSE Tripartite motif protein 2 (Neural ac... 39 0.018
sp|O75369|FLNB_HUMAN Filamin-B (FLN-B) (Beta-filamin) (Acti... 38 0.039
sp|Q9H8W5|TRI45_HUMAN Tripartite motif protein 45 (RING fin... 36 0.11
sp|Q8BTM8|FLNA_MOUSE Filamin-A (Alpha-filamin) (Filamin-1) ... 36 0.11
sp|Q80X90|FLNB_MOUSE Filamin-B (FLN-B) (Beta-filamin) (Acti... 36 0.11
sp|P21333|FLNA_HUMAN Filamin-A (Alpha-filamin) (Filamin-1) ... 35 0.33
sp|Q14315|FLNC_HUMAN Filamin-C (Gamma-filamin) (Filamin-2) ... 35 0.33
sp|Q8VHX6|FLNC_MOUSE Filamin-C (Gamma-filamin) (Filamin-2) ... 35 0.33
sp|P58145|ROAA_ASTLO Ribosomal operon-associated A protein ... 33 1.3
>sp|Q9C040|TRIM2_HUMAN Tripartite motif protein 2 (RING finger protein 86)
Length = 744
Score = 38.9 bits (89), Expect = 0.018
Identities = 48/226 (21%), Positives = 90/226 (39%), Gaps = 11/226 (4%)
Frame = +1
Query: 1 DLNVYFNSLQKQLEKWKMIFSQDVQQDTTTCEGHYEKQRSKVNEYVEKLKECRDQAARLI 180
D++ F+ LQK L K + +++ + + Q + + E +K C + A+ +
Sbjct: 203 DIHSTFDELQKTLNVRKSVLLMELEVNYGLKHKVLQSQLDTLLQGQESIKSCSNFTAQAL 262
Query: 181 STGQVTNCDHVYSIHNLIYSVDEQLKE-----FGSHMTQCMALKFVGRINLDNFDKG--E 339
+ G T V + E+L E F H + L F+ + + K
Sbjct: 263 NHGTETEVLLVKK------QMSEKLNELADQDFPLHpreNDQLDFI--VETEGLKKSIHN 314
Query: 340 IGT-LEKLADFSNAEILPIKLPKIKLGQLFFINFRISKR---FCEATKKYISFSVTKSDE 507
+GT L A S L + +GQ + + C+ Y++ ++ D
Sbjct: 315 LGTILTTNAVASETVATGEGLRQTIIGQPMSVTITTKDKDGELCKTGNAYLTAELSTPDG 374
Query: 508 RIKVGSYLQDNKDGTFTLSFPITAIVPHTVSIYFLGEHIRNSPYTI 645
+ G L DNK+GT+ + + T+S+ +HIR SP+ +
Sbjct: 375 SVADGEIL-DNKNGTYEFLYTVQKEGDFTLSLRLYDQHIRGSPFKL 419
>sp|Q9ESN6|TRIM2_MOUSE Tripartite motif protein 2 (Neural activity-related RING finger
protein)
Length = 744
Score = 38.9 bits (89), Expect = 0.018
Identities = 48/226 (21%), Positives = 90/226 (39%), Gaps = 11/226 (4%)
Frame = +1
Query: 1 DLNVYFNSLQKQLEKWKMIFSQDVQQDTTTCEGHYEKQRSKVNEYVEKLKECRDQAARLI 180
D++ F+ LQK L K + +++ + + Q + + E +K C + A+ +
Sbjct: 203 DIHSTFDELQKTLNVRKSVLLMELEVNYGLKHKVLQSQLDTLLQGQESIKSCSNFTAQAL 262
Query: 181 STGQVTNCDHVYSIHNLIYSVDEQLKE-----FGSHMTQCMALKFVGRINLDNFDKG--E 339
+ G T V + E+L E F H + L F+ + + K
Sbjct: 263 NHGTETEVLLVKK------QMSEKLNELADQDFPLHpreNDQLDFI--VETEGLKKSIHN 314
Query: 340 IGT-LEKLADFSNAEILPIKLPKIKLGQLFFINFRISKR---FCEATKKYISFSVTKSDE 507
+GT L A S L + +GQ + + C+ Y++ ++ D
Sbjct: 315 LGTILTTNAVASETVATGEGLRQTIIGQPMSVTITTKDKDGELCKTGNAYLTAELSTPDG 374
Query: 508 RIKVGSYLQDNKDGTFTLSFPITAIVPHTVSIYFLGEHIRNSPYTI 645
+ G L DNK+GT+ + + T+S+ +HIR SP+ +
Sbjct: 375 SVADGEIL-DNKNGTYEFLYTVQKEGDFTLSLRLYDQHIRGSPFKL 419
>sp|O75369|FLNB_HUMAN Filamin-B (FLN-B) (Beta-filamin) (Actin-binding-like protein)
(Thyroid autoantigen) (Truncated actin-binding protein)
(Truncated ABP) (ABP-280 homolog) (ABP-278) (Filamin 3)
(Filamin homolog 1) (Fh1)
Length = 2602
Score = 37.7 bits (86), Expect = 0.039
Identities = 18/49 (36%), Positives = 26/49 (53%)
Frame = +1
Query: 535 DNKDGTFTLSFPITAIVPHTVSIYFLGEHIRNSPYTILFKVGNNQAVGA 681
DNKDGT T+ + T + H + I ++G HI SP N+ +V A
Sbjct: 1778 DNKDGTVTVRYAPTEVGLHEMHIKYMGSHIPESPLQFYVNYPNSGSVSA 1826
Score = 32.3 bits (72), Expect = 1.6
Identities = 24/66 (36%), Positives = 32/66 (48%), Gaps = 2/66 (3%)
Frame = +1
Query: 535 DNKDGTFTLSFPITAIVPHTVSIY--FLGEHIRNSPYTILFKVGNNQAVGATNGANSIPD 708
+N+DGT+ + + TA P T IY F G I NSP+T++ G AV P
Sbjct: 1666 ENEDGTYDIFY--TAAKPGTYVIYVRFGGVDIPNSPFTVMATDGEVTAV------EEAPV 1717
Query: 709 YNCHPG 726
C PG
Sbjct: 1718 NACPPG 1723
Score = 32.0 bits (71), Expect = 2.1
Identities = 12/51 (23%), Positives = 29/51 (56%)
Frame = +1
Query: 514 KVGSYLQDNKDGTFTLSFPITAIVPHTVSIYFLGEHIRNSPYTILFKVGNN 666
++ +++ DGT+ S+ + HT+++ + G +I +SPY + G++
Sbjct: 691 RIDIQMKNRMDGTYACSYTPVKAIKHTIAVVWGGVNIPHSPYRVNIGQGSH 741
Score = 30.8 bits (68), Expect = 4.8
Identities = 16/44 (36%), Positives = 24/44 (54%)
Frame = +1
Query: 514 KVGSYLQDNKDGTFTLSFPITAIVPHTVSIYFLGEHIRNSPYTI 645
KV +D +DGT +S+ T + VS F EH+ SP+T+
Sbjct: 2044 KVDIQTEDLEDGTCKVSYFPTVPGVYIVSTKFADEHVPGSPFTV 2087
Score = 30.4 bits (67), Expect = 6.2
Identities = 13/37 (35%), Positives = 22/37 (59%)
Frame = +1
Query: 535 DNKDGTFTLSFPITAIVPHTVSIYFLGEHIRNSPYTI 645
DN DGT T+++ + P+ VS+ + E I SP+ +
Sbjct: 1473 DNGDGTHTVTYTPSQEGPYMVSVKYADEEIPRSPFKV 1509
Score = 30.4 bits (67), Expect = 6.2
Identities = 13/36 (36%), Positives = 23/36 (63%)
Frame = +1
Query: 535 DNKDGTFTLSFPITAIVPHTVSIYFLGEHIRNSPYT 642
DNKDGT T+++ T +++ + + +HI SP+T
Sbjct: 1870 DNKDGTCTVTYLPTLPGDYSILVKYNDKHIPGSPFT 1905
>sp|Q9H8W5|TRI45_HUMAN Tripartite motif protein 45 (RING finger protein 99)
Length = 580
Score = 36.2 bits (82), Expect = 0.11
Identities = 17/52 (32%), Positives = 30/52 (57%)
Frame = +1
Query: 490 VTKSDERIKVGSYLQDNKDGTFTLSFPITAIVPHTVSIYFLGEHIRNSPYTI 645
V K + V + +QDNKDGT+ +S+ +TV + +H++ SP+T+
Sbjct: 444 VPKDKKDSPVRTMVQDNKDGTYYISYTPKEPGVYTVWVCIKEQHVQGSPFTV 495
>sp|Q8BTM8|FLNA_MOUSE Filamin-A (Alpha-filamin) (Filamin-1) (Endothelial actin-binding
protein) (Actin-binding protein 280) (ABP-280) (Nonmuscle
filamin)
Length = 2647
Score = 36.2 bits (82), Expect = 0.11
Identities = 18/68 (26%), Positives = 32/68 (47%), Gaps = 1/68 (1%)
Frame = +1
Query: 535 DNKDGTFTLSFPITAIVPHTVSIYFLGEHIRNSPYTILFKVGNNQAVGATNGANSI-PDY 711
+N+DGTF + + + + + F GEH+ NSP+ + G+ V + + P Y
Sbjct: 1702 ENEDGTFDIFYTAPQPGKYVICVRFGGEHVPNSPFQVTALAGDQPTVQTPLRSQQLAPQY 1761
Query: 712 NCHPGEDK 735
N G +
Sbjct: 1762 NYPQGSQQ 1769
Score = 32.7 bits (73), Expect = 1.3
Identities = 14/41 (34%), Positives = 26/41 (63%)
Frame = +1
Query: 523 SYLQDNKDGTFTLSFPITAIVPHTVSIYFLGEHIRNSPYTI 645
+++QDN DGT+T+++ +T+ I + G+ I SPY +
Sbjct: 1594 THIQDNHDGTYTVAYVPDVPGRYTILIKYGGDEIPFSPYRV 1634
Score = 32.0 bits (71), Expect = 2.1
Identities = 16/57 (28%), Positives = 31/57 (54%)
Frame = +1
Query: 496 KSDERIKVGSYLQDNKDGTFTLSFPITAIVPHTVSIYFLGEHIRNSPYTILFKVGNN 666
+ +E V + ++DN +GT++ S+ V HT + + G I NSP+ + G++
Sbjct: 712 QDNEGCSVEATVKDNGNGTYSCSYVPRKPVKHTAMVSWGGVSIPNSPFRVNVGAGSH 768
>sp|Q80X90|FLNB_MOUSE Filamin-B (FLN-B) (Beta-filamin) (Actin-binding-like protein)
(ABP-280-like protein)
Length = 2602
Score = 36.2 bits (82), Expect = 0.11
Identities = 18/49 (36%), Positives = 25/49 (51%)
Frame = +1
Query: 535 DNKDGTFTLSFPITAIVPHTVSIYFLGEHIRNSPYTILFKVGNNQAVGA 681
DNKDGT T+ + T + H + I + G HI SP N+ +V A
Sbjct: 1778 DNKDGTVTVRYAPTEVGLHEMHIKYRGSHIPESPLQFYVNYPNSGSVSA 1826
Score = 31.2 bits (69), Expect = 3.7
Identities = 23/66 (34%), Positives = 32/66 (48%), Gaps = 2/66 (3%)
Frame = +1
Query: 535 DNKDGTFTLSFPITAIVPHTVSIY--FLGEHIRNSPYTILFKVGNNQAVGATNGANSIPD 708
+N+DGT+ + + TA P T IY F G I NSP+T++ G A+ P
Sbjct: 1666 ENEDGTYDIFY--TAAKPGTYVIYVRFGGVDIPNSPFTVMATDGEVTAM------EEAPV 1717
Query: 709 YNCHPG 726
C PG
Sbjct: 1718 NACPPG 1723
Score = 30.8 bits (68), Expect = 4.8
Identities = 12/46 (26%), Positives = 26/46 (56%)
Frame = +1
Query: 529 LQDNKDGTFTLSFPITAIVPHTVSIYFLGEHIRNSPYTILFKVGNN 666
++ DGT+ S+ + HT+++ + G +I +SPY + G++
Sbjct: 696 MKSRMDGTYACSYTPLKAIKHTIAVVWGGVNIPHSPYRVNIGQGSH 741
Score = 30.8 bits (68), Expect = 4.8
Identities = 16/44 (36%), Positives = 24/44 (54%)
Frame = +1
Query: 514 KVGSYLQDNKDGTFTLSFPITAIVPHTVSIYFLGEHIRNSPYTI 645
KV +D +DGT +S+ T + VS F EH+ SP+T+
Sbjct: 2044 KVDIQTEDLEDGTCKVSYFPTVPGVYIVSTKFADEHVPGSPFTV 2087
Score = 30.4 bits (67), Expect = 6.2
Identities = 13/37 (35%), Positives = 22/37 (59%)
Frame = +1
Query: 535 DNKDGTFTLSFPITAIVPHTVSIYFLGEHIRNSPYTI 645
DN DGT T+++ + P+ VS+ + E I SP+ +
Sbjct: 1473 DNGDGTHTVTYTPSQEGPYIVSVKYADEEIPRSPFKV 1509
Score = 30.4 bits (67), Expect = 6.2
Identities = 13/36 (36%), Positives = 23/36 (63%)
Frame = +1
Query: 535 DNKDGTFTLSFPITAIVPHTVSIYFLGEHIRNSPYT 642
DNKDGT T+++ T +++ + + +HI SP+T
Sbjct: 1870 DNKDGTCTVTYLPTLPGDYSILVKYNDKHIPGSPFT 1905
>sp|P21333|FLNA_HUMAN Filamin-A (Alpha-filamin) (Filamin-1) (Endothelial actin-binding
protein) (Actin-binding protein 280) (ABP-280) (Nonmuscle
filamin)
Length = 2647
Score = 34.7 bits (78), Expect = 0.33
Identities = 14/47 (29%), Positives = 26/47 (55%)
Frame = +1
Query: 535 DNKDGTFTLSFPITAIVPHTVSIYFLGEHIRNSPYTILFKVGNNQAV 675
+N+DGTF + + + + + F GEH+ NSP+ + G+ +V
Sbjct: 1702 ENEDGTFDIFYTAPQPGKYVICVRFGGEHVPNSPFQVTALAGDQPSV 1748
Score = 33.5 bits (75), Expect = 0.74
Identities = 14/41 (34%), Positives = 26/41 (63%)
Frame = +1
Query: 523 SYLQDNKDGTFTLSFPITAIVPHTVSIYFLGEHIRNSPYTI 645
+++QDN DGT+T+++ +T+ I + G+ I SPY +
Sbjct: 1594 THIQDNHDGTYTVAYVPDVTGRYTILIKYGGDEIPFSPYRV 1634
Score = 32.0 bits (71), Expect = 2.1
Identities = 16/57 (28%), Positives = 31/57 (54%)
Frame = +1
Query: 496 KSDERIKVGSYLQDNKDGTFTLSFPITAIVPHTVSIYFLGEHIRNSPYTILFKVGNN 666
+ +E V + ++DN +GT++ S+ V HT + + G I NSP+ + G++
Sbjct: 712 QDNEGCPVEALVKDNGNGTYSCSYVPRKPVKHTAMVSWGGVSIPNSPFRVNVGAGSH 768
>sp|Q14315|FLNC_HUMAN Filamin-C (Gamma-filamin) (Filamin-2) (Protein FLNc)
(Actin-binding-like protein) (ABP-L) (ABP-280-like
protein)
Length = 2725
Score = 34.7 bits (78), Expect = 0.33
Identities = 16/37 (43%), Positives = 25/37 (67%)
Frame = +1
Query: 532 QDNKDGTFTLSFPITAIVPHTVSIYFLGEHIRNSPYT 642
+DNKDGT T+S+ TA +++ + F +HI SP+T
Sbjct: 1907 KDNKDGTCTVSYLPTAPGDYSIIVRFDDKHIPGSPFT 1943
Score = 34.3 bits (77), Expect = 0.43
Identities = 15/38 (39%), Positives = 23/38 (60%)
Frame = +1
Query: 535 DNKDGTFTLSFPITAIVPHTVSIYFLGEHIRNSPYTIL 648
+N DGTF + + + ++I F GEHI NSP+ +L
Sbjct: 1696 ENHDGTFDIYYTAPEPGKYVITIRFGGEHIPNSPFHVL 1733
Score = 34.3 bits (77), Expect = 0.43
Identities = 17/67 (25%), Positives = 37/67 (55%)
Frame = +1
Query: 460 EATKKYISFSVTKSDERIKVGSYLQDNKDGTFTLSFPITAIVPHTVSIYFLGEHIRNSPY 639
EA+ + ++ VT +++ ++ +D +++ F + PHTV++ + G+H+ SP+
Sbjct: 2244 EASSQDMTAQVTSPSGKVEAAEIVE-GEDSAYSVRFVPQEMGPHTVAVKYRGQHVPGSPF 2302
Query: 640 TILFKVG 660
F VG
Sbjct: 2303 Q--FTVG 2307
Score = 33.5 bits (75), Expect = 0.74
Identities = 18/51 (35%), Positives = 25/51 (49%)
Frame = +1
Query: 529 LQDNKDGTFTLSFPITAIVPHTVSIYFLGEHIRNSPYTILFKVGNNQAVGA 681
+ DNKDGT T+ + T H + I + G HI SP N++ V A
Sbjct: 1814 ITDNKDGTITVRYAPTEKGLHQMGIKYDGNHIPGSPLQFYVDAINSRHVSA 1864
Score = 30.8 bits (68), Expect = 4.8
Identities = 14/39 (35%), Positives = 20/39 (51%)
Frame = +1
Query: 529 LQDNKDGTFTLSFPITAIVPHTVSIYFLGEHIRNSPYTI 645
L+D D TF ++ PHTV + F G I SP+ +
Sbjct: 428 LEDKGDSTFRCTYRPAMEGPHTVHVAFAGAPITRSPFPV 466
Score = 30.8 bits (68), Expect = 4.8
Identities = 14/38 (36%), Positives = 23/38 (60%)
Frame = +1
Query: 532 QDNKDGTFTLSFPITAIVPHTVSIYFLGEHIRNSPYTI 645
+D KDG+ +S+ + + VSI F EHI +SP+ +
Sbjct: 2362 EDRKDGSCGVSYVVQEPGDYEVSIKFNDEHIPDSPFVV 2399
Score = 30.4 bits (67), Expect = 6.2
Identities = 12/39 (30%), Positives = 23/39 (58%)
Frame = +1
Query: 529 LQDNKDGTFTLSFPITAIVPHTVSIYFLGEHIRNSPYTI 645
++DN DGT T+ + P+TV++ + + + SP+ I
Sbjct: 1493 VRDNGDGTHTVHYTPATDGPYTVAVKYADQEVPRSPFKI 1531
>sp|Q8VHX6|FLNC_MOUSE Filamin-C (Gamma-filamin) (Filamin-2) (FLN-C) (Actin-binding-like
protein) (ABP-L) (ABP-280-like protein)
Length = 1144
Score = 34.7 bits (78), Expect = 0.33
Identities = 16/37 (43%), Positives = 25/37 (67%)
Frame = +1
Query: 532 QDNKDGTFTLSFPITAIVPHTVSIYFLGEHIRNSPYT 642
+DNKDGT T+S+ TA +++ + F +HI SP+T
Sbjct: 326 KDNKDGTCTVSYLPTAPGDYSIIVRFDDKHIPGSPFT 362
Score = 34.3 bits (77), Expect = 0.43
Identities = 15/38 (39%), Positives = 23/38 (60%)
Frame = +1
Query: 535 DNKDGTFTLSFPITAIVPHTVSIYFLGEHIRNSPYTIL 648
+N DGTF + + + ++I F GEHI NSP+ +L
Sbjct: 115 ENHDGTFDIYYTAPEPGKYVITIRFGGEHIPNSPFHVL 152
Score = 33.5 bits (75), Expect = 0.74
Identities = 18/51 (35%), Positives = 25/51 (49%)
Frame = +1
Query: 529 LQDNKDGTFTLSFPITAIVPHTVSIYFLGEHIRNSPYTILFKVGNNQAVGA 681
+ DNKDGT T+ + T H + I + G HI SP N++ V A
Sbjct: 233 ITDNKDGTITVRYAPTEKGLHQMGIKYDGNHIPGSPLQFYVDAINSRHVSA 283
Score = 32.7 bits (73), Expect = 1.3
Identities = 17/67 (25%), Positives = 36/67 (53%)
Frame = +1
Query: 460 EATKKYISFSVTKSDERIKVGSYLQDNKDGTFTLSFPITAIVPHTVSIYFLGEHIRNSPY 639
EA+ + ++ VT + + ++ +D +++ F + PHTV++ + G+H+ SP+
Sbjct: 663 EASSQDMTAQVTSPSGKTEAAEIVE-GEDSAYSVRFVPQEMGPHTVTVKYRGQHVPGSPF 721
Query: 640 TILFKVG 660
F VG
Sbjct: 722 Q--FTVG 726
Score = 30.8 bits (68), Expect = 4.8
Identities = 14/39 (35%), Positives = 25/39 (64%)
Frame = +1
Query: 529 LQDNKDGTFTLSFPITAIVPHTVSIYFLGEHIRNSPYTI 645
++DN DGT+T+S+ +T++I + G+ I SP+ I
Sbjct: 9 IRDNGDGTYTVSYLPDMSGRYTITIKYGGDEIPYSPFRI 47
Score = 30.8 bits (68), Expect = 4.8
Identities = 14/38 (36%), Positives = 23/38 (60%)
Frame = +1
Query: 532 QDNKDGTFTLSFPITAIVPHTVSIYFLGEHIRNSPYTI 645
+D KDG+ +S+ + + VSI F EHI +SP+ +
Sbjct: 781 EDRKDGSCGVSYVVQEPGDYEVSIKFNDEHIPDSPFVV 818
>sp|P58145|ROAA_ASTLO Ribosomal operon-associated A protein (RoaA)
Length = 519
Score = 32.7 bits (73), Expect = 1.3
Identities = 22/90 (24%), Positives = 44/90 (48%), Gaps = 8/90 (8%)
Frame = -1
Query: 825 NFYFNIFQYDLLIIIMSNEIKMSIF------NFRHFFIFSWMTIIIRN*IGSICCSNSL- 667
NF++N+F Y++ II +S + +F N F ++ ++ + N + + +L
Sbjct: 96 NFFYNLFFYNIEIINLSFKFNFFLFYKFCFNNLVKFVMYPFLELKTENFVFNFNFYTNLY 155
Query: 666 -IIANFKQNSIRTIANMFS*KINTNSMRNY 580
I NFK+ ++ ++ IN N+ NY
Sbjct: 156 DIFLNFKKILLKNFMKLYYFTINFNNKFNY 185
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 76,344,485
Number of Sequences: 369166
Number of extensions: 1377215
Number of successful extensions: 4031
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 3841
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 4029
length of database: 68,354,980
effective HSP length: 109
effective length of database: 48,218,865
effective search space used: 8052550455
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)