Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_026_N12
(387 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P16237|HMDH_SCHMA 3-hydroxy-3-methylglutaryl-coenzyme A ... 80 1e-15
sp|P34135|HMDH1_DICDI 3-hydroxy-3-methylglutaryl-coenzyme A... 75 5e-14
sp|P34136|HMDH2_DICDI 3-hydroxy-3-methylglutaryl-coenzyme A... 71 7e-13
sp|P48022|HMDH2_LYCES 3-hydroxy-3-methylglutaryl-coenzyme A... 71 9e-13
sp|Q9XEL8|HMDH2_CAPAN 3-hydroxy-3-methylglutaryl-coenzyme A... 71 9e-13
sp|Q41437|HMDH2_SOLTU 3-hydroxy-3-methylglutaryl-coenzyme A... 71 9e-13
sp|P29057|HMD1_HEVBR 3-hydroxy-3-methylglutaryl-coenzyme A ... 70 1e-12
sp|Q01559|HMDH_NICSY 3-hydroxy-3-methylglutaryl-coenzyme A ... 70 1e-12
sp|Q41438|HMD3_SOLTU 3-hydroxy-3-methylglutaryl-coenzyme A ... 70 1e-12
sp|Q9XHL5|HMDH3_ORYSA 3-hydroxy-3-methylglutaryl-coenzyme A... 69 3e-12
>sp|P16237|HMDH_SCHMA 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA reductase)
Length = 948
Score = 80.5 bits (197), Expect = 1e-15
Identities = 47/130 (36%), Positives = 71/130 (54%), Gaps = 1/130 (0%)
Frame = +1
Query: 1 AECQLTHDIVENILKTDAGSLEKLCIAKXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-TG 177
AE L+ D++ +L T+A L +L +K TG
Sbjct: 716 AEAHLSADVLAQVLHTNAQRLARLTHSKNWIGSAMAGCPGMMGCNAHAANIIAGMFAATG 775
Query: 178 QDLAQVVESSSCITEMEALPQKNNTNKFDLLITCTMPCLEVGVIGGGTKLKAQKSCLSLL 357
QDLAQVV+SSSC+T++E + + L+ + TMPCLEVG +GGGT+L Q++CL LL
Sbjct: 776 QDLAQVVDSSSCLTQLEV-----DLSDDSLVASVTMPCLEVGTVGGGTRLSGQRACLDLL 830
Query: 358 NLNEEKPCEN 387
+L+ ++P E+
Sbjct: 831 DLSVDRPTEH 840
>sp|P34135|HMDH1_DICDI 3-hydroxy-3-methylglutaryl-coenzyme A reductase 1 (HMG-CoA
reductase 1)
Length = 552
Score = 75.1 bits (183), Expect = 5e-14
Identities = 50/131 (38%), Positives = 65/131 (49%), Gaps = 3/131 (2%)
Frame = +1
Query: 4 ECQLTHDIVENILKTDAGSLEKLCIAKXXXXXXXXXXXXXXXXXXXXXXXXXXXXXTGQD 183
E +T D+V+ +LKT+ +L L IAK TGQD
Sbjct: 387 EAMITGDVVQRVLKTNVQALVDLNIAKNLIGSAMAGSIGGFNAHASNIVTAIFLA-TGQD 445
Query: 184 LAQVVESSSCITEMEALPQKNNTNKFDLLITCTMPCLEVGVIGGGTKLKAQKSCLSLLNL 363
AQ VESS+CIT+MEA DL IT TMP +EVG +GGGT L AQ +CL ++ +
Sbjct: 446 CAQNVESSNCITQMEACNDGQ-----DLYITVTMPSIEVGTVGGGTSLPAQSACLDIIGV 500
Query: 364 ---NEEKPCEN 387
+ KP N
Sbjct: 501 KGSSSSKPGAN 511
>sp|P34136|HMDH2_DICDI 3-hydroxy-3-methylglutaryl-coenzyme A reductase 2 (HMG-CoA
reductase 2)
Length = 481
Score = 71.2 bits (173), Expect = 7e-13
Identities = 53/132 (40%), Positives = 67/132 (50%), Gaps = 3/132 (2%)
Frame = +1
Query: 1 AECQLTHDIVENILKTDAGSLEKLCIAKXXXXXXXXXXXXXXXXXXXXXXXXXXXXXTGQ 180
AE ++ DIV ++LKT +L L I K TGQ
Sbjct: 297 AEAVISGDIVRDVLKTTVEALVSLNIDKNLIGSAMAGSIGGFNAHASNIVTALYIA-TGQ 355
Query: 181 DLAQVVESSSCITEMEALPQKNNTNKFDLLITCTMPCLEVGVIGGGTKLKAQKSCLSLLN 360
D AQ VESS+CIT ME++ N K DL I+ TMP +EVG +GGGT L AQ +CL LL
Sbjct: 356 DPAQNVESSNCITLMESI----NGGK-DLYISVTMPSIEVGTVGGGTHLPAQSACLDLLK 410
Query: 361 L---NEEKPCEN 387
+ N E+P N
Sbjct: 411 IRGANLERPGAN 422
>sp|P48022|HMDH2_LYCES 3-hydroxy-3-methylglutaryl-coenzyme A reductase 2 (HMG-CoA
reductase 2)
Length = 602
Score = 70.9 bits (172), Expect = 9e-13
Identities = 49/131 (37%), Positives = 68/131 (51%), Gaps = 3/131 (2%)
Frame = +1
Query: 4 ECQLTHDIVENILKTDAGSLEKLCIAKXXXXXXXXXXXXXXXXXXXXXXXXXXXXXTGQD 183
E +T ++V+ +LKT+ +L +L + K TGQD
Sbjct: 431 EAIITEEVVKKVLKTEVAALVELNMLKNLTGSAMAGALGGFNAHASNIVSAVFIA-TGQD 489
Query: 184 LAQVVESSSCITEMEALPQKNNTNKFDLLITCTMPCLEVGVIGGGTKLKAQKSCLSLLNL 363
AQ +ESS CIT MEA+ N K DL I+ TMP +EVG +GGGT+L +Q +CL+LL +
Sbjct: 490 PAQNIESSHCITMMEAV----NDGK-DLHISVTMPSIEVGTVGGGTQLASQSACLNLLGV 544
Query: 364 ---NEEKPCEN 387
N E P N
Sbjct: 545 KGANREAPGSN 555
>sp|Q9XEL8|HMDH2_CAPAN 3-hydroxy-3-methylglutaryl-coenzyme A reductase 2 (HMG-CoA
reductase 2)
Length = 604
Score = 70.9 bits (172), Expect = 9e-13
Identities = 49/131 (37%), Positives = 68/131 (51%), Gaps = 3/131 (2%)
Frame = +1
Query: 4 ECQLTHDIVENILKTDAGSLEKLCIAKXXXXXXXXXXXXXXXXXXXXXXXXXXXXXTGQD 183
E +T ++V+ +LKT+ +L +L + K TGQD
Sbjct: 433 EAIITEEVVKKVLKTEVAALVELNMLKNLTGSALAGALGGFNAHASNIVSAVYIA-TGQD 491
Query: 184 LAQVVESSSCITEMEALPQKNNTNKFDLLITCTMPCLEVGVIGGGTKLKAQKSCLSLLNL 363
AQ +ESS CIT MEA+ N K DL I+ TMP +EVG +GGGT+L +Q +CL+LL +
Sbjct: 492 PAQNIESSHCITMMEAV----NDGK-DLHISVTMPSIEVGTVGGGTQLASQSACLNLLGV 546
Query: 364 ---NEEKPCEN 387
N E P N
Sbjct: 547 KGANREAPGSN 557
>sp|Q41437|HMDH2_SOLTU 3-hydroxy-3-methylglutaryl-coenzyme A reductase 2 (HMG-CoA
reductase 2) (HMG2.2)
Length = 595
Score = 70.9 bits (172), Expect = 9e-13
Identities = 49/131 (37%), Positives = 68/131 (51%), Gaps = 3/131 (2%)
Frame = +1
Query: 4 ECQLTHDIVENILKTDAGSLEKLCIAKXXXXXXXXXXXXXXXXXXXXXXXXXXXXXTGQD 183
E +T ++V+ +LKT+ +L +L + K TGQD
Sbjct: 428 EAIITEEVVKKVLKTEVAALVELNMLKNLTGSAMAGALGGFNAHASNIVSAVFIA-TGQD 486
Query: 184 LAQVVESSSCITEMEALPQKNNTNKFDLLITCTMPCLEVGVIGGGTKLKAQKSCLSLLNL 363
AQ +ESS CIT MEA+ N K DL I+ TMP +EVG +GGGT+L +Q +CL+LL +
Sbjct: 487 PAQNIESSHCITMMEAV----NDGK-DLHISVTMPSIEVGTVGGGTQLASQSACLNLLGV 541
Query: 364 ---NEEKPCEN 387
N E P N
Sbjct: 542 KGANREAPGSN 552
>sp|P29057|HMD1_HEVBR 3-hydroxy-3-methylglutaryl-coenzyme A reductase 1 (HMG-CoA
reductase 1)
Length = 575
Score = 70.5 bits (171), Expect = 1e-12
Identities = 50/131 (38%), Positives = 68/131 (51%), Gaps = 3/131 (2%)
Frame = +1
Query: 4 ECQLTHDIVENILKTDAGSLEKLCIAKXXXXXXXXXXXXXXXXXXXXXXXXXXXXXTGQD 183
E + ++V+ +LKT+ SL +L + K TGQD
Sbjct: 404 EAIIKEEVVKKVLKTNVASLVELNMLKNLAGSAVAGALGGFNAHAGNIVSAIFIA-TGQD 462
Query: 184 LAQVVESSSCITEMEALPQKNNTNKFDLLITCTMPCLEVGVIGGGTKLKAQKSCLSLLNL 363
AQ VESS CIT MEA+ N K DL I+ TMP +EVG +GGGT+L +Q +CL+LL +
Sbjct: 463 PAQNVESSHCITMMEAV----NDGK-DLHISVTMPSIEVGTVGGGTQLASQSACLNLLGV 517
Query: 364 ---NEEKPCEN 387
N+E P N
Sbjct: 518 KGANKESPGSN 528
>sp|Q01559|HMDH_NICSY 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA reductase)
Length = 604
Score = 70.1 bits (170), Expect = 1e-12
Identities = 48/131 (36%), Positives = 68/131 (51%), Gaps = 3/131 (2%)
Frame = +1
Query: 4 ECQLTHDIVENILKTDAGSLEKLCIAKXXXXXXXXXXXXXXXXXXXXXXXXXXXXXTGQD 183
E +T ++V+ +LKT+ +L +L + K TGQD
Sbjct: 433 EAIITEEVVKKVLKTEVAALVELNMLKNLTGSAMAGALGGFNAHASNIVSAVYIA-TGQD 491
Query: 184 LAQVVESSSCITEMEALPQKNNTNKFDLLITCTMPCLEVGVIGGGTKLKAQKSCLSLLNL 363
AQ +ESS CIT MEA+ N K DL ++ TMP +EVG +GGGT+L +Q +CL+LL +
Sbjct: 492 PAQNIESSHCITMMEAV----NDGK-DLHVSVTMPSIEVGTVGGGTQLASQSACLNLLGV 546
Query: 364 ---NEEKPCEN 387
N E P N
Sbjct: 547 KGANREVPGSN 557
>sp|Q41438|HMD3_SOLTU 3-hydroxy-3-methylglutaryl-coenzyme A reductase 3 (HMG-CoA
reductase 3) (HMG3.3)
Length = 574
Score = 70.1 bits (170), Expect = 1e-12
Identities = 49/131 (37%), Positives = 67/131 (51%), Gaps = 3/131 (2%)
Frame = +1
Query: 4 ECQLTHDIVENILKTDAGSLEKLCIAKXXXXXXXXXXXXXXXXXXXXXXXXXXXXXTGQD 183
E + D+V+ +LKT+ +L +L + K TGQD
Sbjct: 406 EAIIKEDVVKKVLKTEVATLVELNMLKNLTGSAMAGALGGFNAHASNIVSAVYLA-TGQD 464
Query: 184 LAQVVESSSCITEMEALPQKNNTNKFDLLITCTMPCLEVGVIGGGTKLKAQKSCLSLLNL 363
AQ +ESS CIT MEA+ N K DL I+ TMP +EVG +GGGT+L +Q +CL+LL +
Sbjct: 465 PAQNIESSHCITMMEAV----NDGK-DLHISVTMPSIEVGTVGGGTQLASQSACLNLLGV 519
Query: 364 ---NEEKPCEN 387
N E P N
Sbjct: 520 KGANREAPGSN 530
>sp|Q9XHL5|HMDH3_ORYSA 3-hydroxy-3-methylglutaryl-coenzyme A reductase 3 (HMG-CoA
reductase 3)
Length = 560
Score = 68.9 bits (167), Expect = 3e-12
Identities = 48/131 (36%), Positives = 64/131 (48%), Gaps = 3/131 (2%)
Frame = +1
Query: 4 ECQLTHDIVENILKTDAGSLEKLCIAKXXXXXXXXXXXXXXXXXXXXXXXXXXXXXTGQD 183
E + D+V+ +LKT+ SL +L + K TGQD
Sbjct: 389 EAVIKEDVVKKVLKTNVQSLVELNVIKNLAGSAVAGALGGFNAHASNIVTAIFIA-TGQD 447
Query: 184 LAQVVESSSCITEMEALPQKNNTNKFDLLITCTMPCLEVGVIGGGTKLKAQKSCLSLLNL 363
AQ VESS CIT +EA+ DL I+ TMP +EVG +GGGT+L +Q +CL LL +
Sbjct: 448 PAQNVESSHCITMLEAVNDGR-----DLHISVTMPSIEVGTVGGGTQLASQAACLDLLGV 502
Query: 364 ---NEEKPCEN 387
N E P N
Sbjct: 503 KGANRESPGSN 513
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.314 0.130 0.375
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 42,831,886
Number of Sequences: 369166
Number of extensions: 753398
Number of successful extensions: 1304
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 1238
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 1257
length of database: 68,354,980
effective HSP length: 95
effective length of database: 50,805,155
effective search space used: 1676570115
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)