Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_026_N07
(928 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q9UNI6|DUS12_HUMAN Dual specificity protein phosphatase ... 153 6e-37
sp|Q9D0T2|DUS12_MOUSE Dual specificity protein phosphatase ... 147 4e-35
sp|Q02256|PVH1_YEAST Tyrosine-protein phosphatase YVH1 (PTP... 103 7e-22
sp|Q16690|DUS5_HUMAN Dual specificity protein phosphatase 5... 88 3e-17
sp|O54838|DUS5_RAT Dual specificity protein phosphatase 5 (... 86 1e-16
sp|Q16828|DUS6_HUMAN Dual specificity protein phosphatase 6... 75 3e-13
sp|Q64346|DUS6_RAT Dual specificity protein phosphatase 6 (... 75 3e-13
sp|Q9DBB1|DUS6_MOUSE Dual specificity protein phosphatase 6... 75 3e-13
sp|Q16829|DUS7_HUMAN Dual specificity protein phosphatase 7... 73 1e-12
sp|Q63340|DUS7_RAT Dual specificity protein phosphatase 7 (... 73 1e-12
>sp|Q9UNI6|DUS12_HUMAN Dual specificity protein phosphatase 12 (Dual-specificity tyrosine
phosphatase YVH1)
Length = 340
Score = 153 bits (387), Expect = 6e-37
Identities = 103/285 (36%), Positives = 150/285 (52%), Gaps = 33/285 (11%)
Frame = +1
Query: 10 LKSLHIKSILTVMDTPLEHKI-----DLFQYKFIKAYDVLDQDLISHFDDACEFIDKGRE 174
L+ I ++LTV K DL++ F+ A D + DL+SH D FI + R
Sbjct: 48 LREAGITAVLTVDSEEPSFKAGPGVEDLWRL-FVPALDKPETDLLSHLDRCVAFIGQARA 106
Query: 175 KG--VLVHCLAGISRSGTIMTAYLMKTLQIDPNEAIAKIKE-KSYICPNDGFKQQLKMYY 345
+G VLVHC AG+SRS I+TA+LMKT Q+ +A K++ K N+GF+ QLK+Y
Sbjct: 107 EGRAVLVHCHAGVSRSVAIITAFLMKTDQLPFEKAYEKLQILKPEAKMNEGFEWQLKLYQ 166
Query: 346 NMKYCGQYKSDEYKQF-VQICQRDDIDVCNVVSKMPTTPKSTV-----DPVQYKCRKCRA 507
M Y S YKQ+ +Q ++ N+ ++ +TV D V YKCRKCR
Sbjct: 167 AMGYEVDTSSAIYKQYRLQKVTEKYPELQNLPQELFAVDPTTVSQGLKDEVLYKCRKCRR 226
Query: 508 MLFDNTNLVEH-----------------SKLNSENTICTEEVFIEALSWIDSS--NVTGG 630
LF ++++++H S L + FIE + W++S+ V G
Sbjct: 227 SLFRSSSILDHREGSGPIAFAHKRMTPSSMLTTGRQAQCTSYFIEPVQWMESALLGVMDG 286
Query: 631 KINCPKCHSKLGSYTWVGERCVCGNWVVPAFHIAKQKVDSVKSNP 765
++ CPKC +KLGS+ W GE+C CG W+ PAF I K +VD +K P
Sbjct: 287 QLLCPKCSAKLGSFNWYGEQCSCGRWITPAFQIHKNRVDEMKILP 331
>sp|Q9D0T2|DUS12_MOUSE Dual specificity protein phosphatase 12 (Dual specificity
phosphatase T-DSP4) (Dual specificity phosphatase VH1)
Length = 339
Score = 147 bits (371), Expect = 4e-35
Identities = 90/255 (35%), Positives = 140/255 (54%), Gaps = 30/255 (11%)
Frame = +1
Query: 91 FIKAYDVLDQDLISHFDDACEFIDKGREKG--VLVHCLAGISRSGTIMTAYLMKTLQIDP 264
F+ A D + DL+SH D FI + R +G VLVHC AG+SRS ++ A++MKT Q+
Sbjct: 78 FVPALDKPETDLLSHLDRCVAFIGQARSEGRAVLVHCHAGVSRSVAVVMAFIMKTDQLTF 137
Query: 265 NEA---IAKIKEKSYICPNDGFKQQLKMYYNMKYCGQYKSDEYKQF-VQICQRDDIDVCN 432
+A + +K ++ + N+GF+ QLK+Y M Y S YKQ+ +Q + N
Sbjct: 138 EKAYDILRTVKPEAKV--NEGFEWQLKLYEAMGYEVDTSSAFYKQYRLQKVTEKCPKLWN 195
Query: 433 VVSKMPTTPKSTV-----DPVQYKCRKCRAMLFDNTNLVEHS----------KLNSENTI 567
+ ++ +T+ D + YKCRKCR LF +++++ HS K + +++
Sbjct: 196 LPQELFAVDPTTISQGLKDDILYKCRKCRRSLFRHSSILGHSEGSGPIAFAHKRTAPSSV 255
Query: 568 CTE-------EVFIEALSWIDSS--NVTGGKINCPKCHSKLGSYTWVGERCVCGNWVVPA 720
T FIE + W++S+ V G++ CPKC +KLGS+ W GE+C CG W+ PA
Sbjct: 256 LTTGSQAQCTSYFIEPVQWMESTLLGVMDGQLLCPKCSAKLGSFNWYGEQCSCGRWITPA 315
Query: 721 FHIAKQKVDSVKSNP 765
F I K +VD +K P
Sbjct: 316 FQIHKNRVDEMKMLP 330
>sp|Q02256|PVH1_YEAST Tyrosine-protein phosphatase YVH1 (PTPase YVH1)
Length = 364
Score = 103 bits (257), Expect = 7e-22
Identities = 79/271 (29%), Positives = 112/271 (41%), Gaps = 62/271 (22%)
Frame = +1
Query: 121 DLISHFDDACEFID-------------------KGREKGVLVHCLAGISRSGTIMTAYLM 243
D++ +FD+ FID K + V HC AG+SRS T + AYLM
Sbjct: 74 DVLQYFDETNRFIDQCLFPNEVEYSPRLVDFKKKPQRGAVFAHCQAGLSRSVTFIVAYLM 133
Query: 244 KTLQIDPNEAIAKIKEKS-YICPNDGFKQQLKMYYNMKYC------GQYKSDEYKQFVQI 402
+ + A+ +K K + PN+ F +QL ++ M YK + KQ +++
Sbjct: 134 YRYGLSLSMAMHAVKRKKPSVEPNENFMEQLHLFEKMGGDFVDFDNPAYKQWKLKQSIKL 193
Query: 403 CQRDDIDVCNV-----------VSKMPTTPKSTVDPVQYKCRKCRAMLFDNTNLVEHSK- 546
V N + K+ KS V V +C+KCR L +T+ + H
Sbjct: 194 DPSGSELVSNSGMFKDSESSQDLDKLTEAEKSKVTAV--RCKKCRTKLALSTSFIAHDPP 251
Query: 547 -------------LNSENTICTEE-------VFIEALSW----IDSSNVTGGKINCPKCH 654
NS I +E FIE L W + GK +CP C
Sbjct: 252 SKESSEGHFIKRAANSHRIIDIQESQANCSHFFIEPLKWMQPELQGKQELEGKFSCPGCS 311
Query: 655 SKLGSYTWVGERCVCGNWVVPAFHIAKQKVD 747
SK+G Y W G RC CG WV+PA H+ KVD
Sbjct: 312 SKVGGYNWKGSRCSCGKWVIPAIHLQTSKVD 342
>sp|Q16690|DUS5_HUMAN Dual specificity protein phosphatase 5 (Dual specificity protein
phosphatase hVH3)
Length = 384
Score = 88.2 bits (217), Expect = 3e-17
Identities = 56/116 (48%), Positives = 67/116 (57%), Gaps = 3/116 (2%)
Frame = +1
Query: 4 ELLKSLHIKSILTVMDTPLEHKIDLFQYKFIKAYDVLDQDLISHFDDACEFIDKGREKG- 180
E L +LHI ++L V E + YK+I D D+ SHF +A +FID REKG
Sbjct: 198 EFLANLHITALLNVSRRTSEACMTHLHYKWIPVEDSHTADISSHFQEAIDFIDCVREKGG 257
Query: 181 -VLVHCLAGISRSGTIMTAYLMKTLQIDPNEAIAKIKE-KSYICPNDGFKQQLKMY 342
VLVHC AGISRS TI AYLMKT Q EA IK+ +S + PN GF QL Y
Sbjct: 258 KVLVHCEAGISRSPTICMAYLMKTKQFRLKEAFDYIKQRRSMVSPNFGFMGQLLQY 313
>sp|O54838|DUS5_RAT Dual specificity protein phosphatase 5 (MAP-kinase phosphatase
CPG21)
Length = 384
Score = 85.9 bits (211), Expect = 1e-16
Identities = 54/116 (46%), Positives = 66/116 (56%), Gaps = 3/116 (2%)
Frame = +1
Query: 4 ELLKSLHIKSILTVMDTPLEHKIDLFQYKFIKAYDVLDQDLISHFDDACEFIDKGREKG- 180
E L +LHI ++L V E YK+I D D+ SHF +A +FID RE+G
Sbjct: 198 EFLANLHITALLNVSRRTSEACTTHLHYKWIPVEDSHTADISSHFQEAIDFIDCVREEGG 257
Query: 181 -VLVHCLAGISRSGTIMTAYLMKTLQIDPNEAIAKIKE-KSYICPNDGFKQQLKMY 342
VLVHC AG+SRS TI AYLMKT Q EA IK+ +S + PN GF QL Y
Sbjct: 258 KVLVHCEAGVSRSPTICMAYLMKTKQFRLKEAFEYIKQRRSVVSPNFGFMGQLLQY 313
>sp|Q16828|DUS6_HUMAN Dual specificity protein phosphatase 6 (Mitogen-activated protein
kinase phosphatase 3) (MAP kinase phosphatase 3) (MKP-3)
(Dual specificity protein phosphatase PYST1)
Length = 381
Score = 74.7 bits (182), Expect = 3e-13
Identities = 53/118 (44%), Positives = 67/118 (56%), Gaps = 7/118 (5%)
Frame = +1
Query: 1 IELLKSLHIKSILTVMDTP----LEHKIDLFQYKFIKAYDVLDQDLISHFDDACEFIDKG 168
+++L+ IK IL V TP L F+YK I D Q+L F +A FID+
Sbjct: 225 LDVLEEFGIKYILNV--TPNLPNLFENAGEFKYKQIPISDHWSQNLSQFFPEAISFIDEA 282
Query: 169 REK--GVLVHCLAGISRSGTIMTAYLMKTLQIDPNEAIAKIK-EKSYICPNDGFKQQL 333
R K GVLVHCLAGISRS T+ AYLM+ L + N+A +K +KS I PN F QL
Sbjct: 283 RGKNCGVLVHCLAGISRSVTVTVAYLMQKLNLSMNDAYDIVKMKKSNISPNFNFMGQL 340
>sp|Q64346|DUS6_RAT Dual specificity protein phosphatase 6 (Mitogen-activated protein
kinase phosphatase 3) (MAP kinase phosphatase 3) (MKP-3)
Length = 381
Score = 74.7 bits (182), Expect = 3e-13
Identities = 53/118 (44%), Positives = 67/118 (56%), Gaps = 7/118 (5%)
Frame = +1
Query: 1 IELLKSLHIKSILTVMDTP----LEHKIDLFQYKFIKAYDVLDQDLISHFDDACEFIDKG 168
+++L+ IK IL V TP L F+YK I D Q+L F +A FID+
Sbjct: 225 LDVLEEFGIKYILNV--TPNLPNLFENAGEFKYKQIPISDHWSQNLSQFFPEAISFIDEA 282
Query: 169 REK--GVLVHCLAGISRSGTIMTAYLMKTLQIDPNEAIAKIK-EKSYICPNDGFKQQL 333
R K GVLVHCLAGISRS T+ AYLM+ L + N+A +K +KS I PN F QL
Sbjct: 283 RGKNCGVLVHCLAGISRSVTVTVAYLMQKLNLSMNDAYDIVKMKKSNISPNFNFMGQL 340
>sp|Q9DBB1|DUS6_MOUSE Dual specificity protein phosphatase 6 (Mitogen-activated protein
kinase phosphatase 3) (MAP kinase phosphatase 3) (MKP-3)
Length = 381
Score = 74.7 bits (182), Expect = 3e-13
Identities = 53/118 (44%), Positives = 67/118 (56%), Gaps = 7/118 (5%)
Frame = +1
Query: 1 IELLKSLHIKSILTVMDTP----LEHKIDLFQYKFIKAYDVLDQDLISHFDDACEFIDKG 168
+++L+ IK IL V TP L F+YK I D Q+L F +A FID+
Sbjct: 225 LDVLEEFGIKYILNV--TPNLPNLFENAGEFKYKQIPISDHWSQNLSQFFPEAISFIDEA 282
Query: 169 REK--GVLVHCLAGISRSGTIMTAYLMKTLQIDPNEAIAKIK-EKSYICPNDGFKQQL 333
R K GVLVHCLAGISRS T+ AYLM+ L + N+A +K +KS I PN F QL
Sbjct: 283 RGKNCGVLVHCLAGISRSVTVTVAYLMQKLNLSMNDAYDIVKMKKSNISPNFNFMGQL 340
>sp|Q16829|DUS7_HUMAN Dual specificity protein phosphatase 7 (Dual specificity protein
phosphatase PYST2)
Length = 368
Score = 73.2 bits (178), Expect = 1e-12
Identities = 51/117 (43%), Positives = 66/117 (56%), Gaps = 6/117 (5%)
Frame = +1
Query: 1 IELLKSLHIKSILTV---MDTPLEHKIDLFQYKFIKAYDVLDQDLISHFDDACEFIDKGR 171
+++L IK IL V + EH + F YK I D Q+L F +A FID+ R
Sbjct: 212 LDVLGKYGIKYILNVTPNLPNAFEHGGE-FTYKQIPISDHWSQNLSQFFPEAISFIDEAR 270
Query: 172 EK--GVLVHCLAGISRSGTIMTAYLMKTLQIDPNEAIAKIK-EKSYICPNDGFKQQL 333
K GVLVHCLAGISRS T+ AYLM+ + + N+A +K +KS I PN F QL
Sbjct: 271 SKKCGVLVHCLAGISRSVTVTVAYLMQKMNLSLNDAYDFVKRKKSNISPNFNFMGQL 327
>sp|Q63340|DUS7_RAT Dual specificity protein phosphatase 7 (Dual specificity protein
phosphatase MKP-X)
Length = 280
Score = 73.2 bits (178), Expect = 1e-12
Identities = 51/117 (43%), Positives = 66/117 (56%), Gaps = 6/117 (5%)
Frame = +1
Query: 1 IELLKSLHIKSILTV---MDTPLEHKIDLFQYKFIKAYDVLDQDLISHFDDACEFIDKGR 171
+++L IK IL V + EH + F YK I D Q+L F +A FID+ R
Sbjct: 124 LDVLGKYGIKYILNVTPNLPNAFEHGGE-FTYKQIPISDHWSQNLSQFFPEAISFIDEAR 182
Query: 172 EK--GVLVHCLAGISRSGTIMTAYLMKTLQIDPNEAIAKIK-EKSYICPNDGFKQQL 333
K GVLVHCLAGISRS T+ AYLM+ + + N+A +K +KS I PN F QL
Sbjct: 183 SKKCGVLVHCLAGISRSVTVTVAYLMQKMNLSLNDAYDFVKRKKSNISPNFNFMGQL 239
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 105,785,066
Number of Sequences: 369166
Number of extensions: 2238109
Number of successful extensions: 7145
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 6125
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 7036
length of database: 68,354,980
effective HSP length: 110
effective length of database: 48,034,130
effective search space used: 9510757740
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)