Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_026_M18
(632 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q9P2N4|ATS9_HUMAN ADAMTS-9 precursor (A disintegrin and ... 58 2e-08
sp|P59511|ATS20_MOUSE ADAMTS-20 precursor (A disintegrin an... 55 1e-07
sp|Q9H324|ATS10_HUMAN ADAMTS-10 precursor (A disintegrin an... 54 4e-07
sp|P59509|ATS19_MOUSE ADAMTS-19 precursor (A disintegrin an... 50 5e-06
sp|P59510|ATS20_HUMAN ADAMTS-20 precursor (A disintegrin an... 49 8e-06
sp|Q4VC17|ATS18_MOUSE ADAMTS-18 precursor (A disintegrin an... 47 3e-05
sp|O15072|ATS3_HUMAN ADAMTS-3 precursor (A disintegrin and ... 47 3e-05
sp|P58459|ATS10_MOUSE ADAMTS-10 (A disintegrin and metallop... 46 9e-05
sp|Q8TE59|ATS19_HUMAN ADAMTS-19 precursor (A disintegrin an... 46 9e-05
sp|O95450|ATS2_HUMAN ADAMTS-2 precursor (A disintegrin and ... 45 1e-04
>sp|Q9P2N4|ATS9_HUMAN ADAMTS-9 precursor (A disintegrin and metalloproteinase with
thrombospondin motifs 9) (ADAM-TS 9) (ADAM-TS9)
Length = 1935
Score = 57.8 bits (138), Expect = 2e-08
Identities = 43/165 (26%), Positives = 68/165 (41%), Gaps = 2/165 (1%)
Frame = +1
Query: 7 GYQKRTVTCEKIEAQYYKIVDDRFCLNTKPITIKHCKSSALCPSWKVEKSDNFQCSDVCV 186
G Q+R C ++DD C + + +TI+ C S CP WK D +C C
Sbjct: 1016 GTQRRRAICVNTRND---VLDDSKCTHQEKVTIQRC-SEFPCPQWK--SGDWSECLVTC- 1068
Query: 187 NVGVAKTNTKIICQHNNKTVDSSFCDRDKQPSI--TCPNTNCDVLYEYGLWSQCSMSCSN 360
G + ++ CQ ++ CD + +P+ TC C ++ G W QCS++C
Sbjct: 1069 --GKGHKHRQVWCQFGEDRLNDRMCDPETKPTSMQTCQQPEC-ASWQAGPWVQCSVTCGQ 1125
Query: 361 TTNVSIRSRTMKCIWKHTKKPAYHLCQLHQVNRERLTKSCRVPKC 495
+ R +KCI T + R T+ C +P C
Sbjct: 1126 ----GYQLRAVKCI-IGTYMSVVDDNDCNAATRPTDTQDCELPSC 1165
Score = 48.5 bits (114), Expect = 1e-05
Identities = 41/156 (26%), Positives = 70/156 (44%), Gaps = 6/156 (3%)
Frame = +1
Query: 7 GYQKRTVTCEKIEAQYYKIVDDRFCLN-TKPITIKHCKSSALCP--SWKVEKSDNFQCSD 177
G Q+R V C+ +KI + C T+P + + C+ CP +W+ E+ +C+
Sbjct: 1516 GVQQRHVGCQ---IGTHKIARETECNPYTRPESERDCQGPR-CPLYTWRAEEWQ--ECTK 1569
Query: 178 VCVNVGVAKTNTKIICQHNNKT-VDSSFCDRDKQP--SITCPNTNCDVLYEYGLWSQCSM 348
C G K++C +NK V + CD K+P +C C+ ++ G WS+CS+
Sbjct: 1570 TC---GEGSRYRKVVCVDDNKNEVHGARCDVSKRPVDRESCSLQPCEYVWITGEWSECSV 1626
Query: 349 SCSNTTNVSIRSRTMKCIWKHTKKPAYHLCQLHQVN 456
+C + R + C +T K Y +N
Sbjct: 1627 TCGK----GYKQRLVSCSEIYTGKENYEYSYQTTIN 1658
Score = 36.2 bits (82), Expect = 0.072
Identities = 38/151 (25%), Positives = 59/151 (39%), Gaps = 20/151 (13%)
Frame = +1
Query: 7 GYQKRTVTCEKIEAQYYKIVDDRFC-LNTKPITIKHCKSSALCPSWKVEKSDNFQCSDVC 183
G++ R V C+ E + ++DR C TKP +++ C+ C SW+ QCS C
Sbjct: 1071 GHKHRQVWCQFGEDR----LNDRMCDPETKPTSMQTCQQPE-CASWQA--GPWVQCSVTC 1123
Query: 184 VNVGVAKTNTKIICQHNNKTVDSSFCDRDKQPSIT--CPNTNCD---------------- 309
G K I VD + C+ +P+ T C +C
Sbjct: 1124 -GQGYQLRAVKCIIGTYMSVVDDNDCNAATRPTDTQDCELPSCHPPPAAPETRRSTYSAP 1182
Query: 310 -VLYEYGLWSQCSMSCSNTTNVSIRSRTMKC 399
+ +G W+ CS +C T R R + C
Sbjct: 1183 RTQWRFGSWTPCSATCGKGT----RMRYVSC 1209
Score = 34.3 bits (77), Expect = 0.27
Identities = 42/190 (22%), Positives = 76/190 (40%), Gaps = 9/190 (4%)
Frame = +1
Query: 7 GYQKRTVTCEKIEAQYYKIVDDRFC-LNTKPITIKHCKSSALCPSWKVEKSDNFQCSDVC 183
G + R V C++ + + D C + KP + C + A CP + + V
Sbjct: 1401 GIRTRLVVCQRSNGERFP---DLSCEILDKPPDREQCNTHA-CPHDAAWSTGPWSSCSVS 1456
Query: 184 VNVGVAKTNTKIICQHNNKTVDSSFCDRDKQPS--ITCPNTNCDVLYEYGLWSQCSMSCS 357
G + N + + + ++S +C +P C C ++ G WSQCS+SC
Sbjct: 1457 CGRGHKQRNVYCMAKDGSH-LESDYCKHLAKPHGHRKCRGGRCPK-WKAGAWSQCSVSCG 1514
Query: 358 NTTNVSIRSRTMKCIWKHTKKPAYHLCQLHQVNRERLTKSCRVPKCIL------GCKDLT 519
++ R + C T K A + + R + C+ P+C L ++ T
Sbjct: 1515 R----GVQQRHVGC-QIGTHKIARE-TECNPYTRPESERDCQGPRCPLYTWRAEEWQECT 1568
Query: 520 PACVKQSKFR 549
C + S++R
Sbjct: 1569 KTCGEGSRYR 1578
Score = 33.1 bits (74), Expect = 0.61
Identities = 29/97 (29%), Positives = 41/97 (42%), Gaps = 16/97 (16%)
Frame = +1
Query: 274 QPSITCPNTN-----------CDV--LYEYGLWSQCSMSCSNTTNVSIRSRTMKCIWKHT 414
Q +I CP T C V + G W CS+SC V + R+++C+
Sbjct: 1654 QTTINCPGTQPPSVHPCYLRECPVSATWRVGNWGSCSVSC----GVGVMQRSVQCLTNED 1709
Query: 415 KKPAYHLCQLHQVNRERLTKSCR-VPKCIL--GCKDL 516
+ HLC ER K+CR V C L CK++
Sbjct: 1710 QPS--HLCHTDLKPEER--KTCRNVYNCELPQNCKEV 1742
Score = 30.8 bits (68), Expect = 3.0
Identities = 31/128 (24%), Positives = 47/128 (36%), Gaps = 8/128 (6%)
Frame = +1
Query: 7 GYQKRTVTCEKIEAQYYKIVDDRFCLNTKPITIKHCKSSALCPSWKVEKSDNFQCSDVCV 186
G +KR + C + E+ + D R +P I + W V + +CS C
Sbjct: 896 GERKRKLVCTR-ESDQLTVSDQRCDRLPQPGHITEPCGTDCDLRWHV--ASRSECSAQC- 951
Query: 187 NVGVAKTNTKIICQHNNKT------VDSSFCDRDKQPSIT--CPNTNCDVLYEYGLWSQC 342
G+ I C ++ VD FC +PS C + Y W++C
Sbjct: 952 --GLGYRTLDIYCAKYSRLDGKTEKVDDGFCSSHPKPSNREKCSGECNTGGWRYSAWTEC 1009
Query: 343 SMSCSNTT 366
S SC T
Sbjct: 1010 SKSCDGGT 1017
>sp|P59511|ATS20_MOUSE ADAMTS-20 precursor (A disintegrin and metalloproteinase with
thrombospondin motifs 20) (ADAM-TS 20) (ADAM-TS20)
Length = 1906
Score = 55.5 bits (132), Expect = 1e-07
Identities = 46/170 (27%), Positives = 70/170 (41%), Gaps = 7/170 (4%)
Frame = +1
Query: 7 GYQKRTVTCEKIEAQYYKIVDDRFCLNTKPITIKHCKSSALCPSWKVEKSDNFQCSDVCV 186
G Q R V C+ + + D ++KP +HC S CP W D +C+ C
Sbjct: 1319 GLQHRAVVCQDEDGRSATSCDG----SSKPPESRHCGSGP-CPHWNY--GDWGECTQTC- 1370
Query: 187 NVGVAKTNTKIICQH-NNKTVDSSFCDRDKQPSI------TCPNTNCDVLYEYGLWSQCS 345
G + +ICQ N + C+ K PS+ CP DV + G W CS
Sbjct: 1371 --GGGVKSRFVICQFPNGQMTQEHSCELPKPPSMMQCHLHACPE---DVSWYRGPWKSCS 1425
Query: 346 MSCSNTTNVSIRSRTMKCIWKHTKKPAYHLCQLHQVNRERLTKSCRVPKC 495
SC ++ R + CI + +K C +++ R K+CR +C
Sbjct: 1426 ASCGK----GVKYREVLCIDQFQRKLEEKYCS--HLHKPRTHKACRSGRC 1469
Score = 51.2 bits (121), Expect = 2e-06
Identities = 46/169 (27%), Positives = 71/169 (42%), Gaps = 6/169 (3%)
Frame = +1
Query: 7 GYQKRTVTCEKIEAQYYKIVDDRFCLNT-KPITIKHCKSSALCPSWKVEKSDNFQCSDVC 183
G + R V C Q+ + +++++C + KP T K C+S CPSWK K +CS C
Sbjct: 1431 GVKYREVLCID---QFQRKLEEKYCSHLHKPRTHKACRSGR-CPSWKANKWK--ECSVTC 1484
Query: 184 VNVGVAKTNTKIICQ-HNNKTVDSSFCDRDKQP--SITCPNTNCDVLYEY--GLWSQCSM 348
G ++ C+ V CD +P C +C + Y++ G W CS
Sbjct: 1485 ---GSGVQQREVYCRLRGTGRVSEDMCDPSTRPQGQRQCWRQDC-MRYQWTTGDWLDCST 1540
Query: 349 SCSNTTNVSIRSRTMKCIWKHTKKPAYHLCQLHQVNRERLTKSCRVPKC 495
SC R +KC+ + + LC + + K CR P C
Sbjct: 1541 SCKKKETY----RLVKCVNEQNVQANESLCD--PLTKPLSIKKCRNPHC 1583
Score = 38.9 bits (89), Expect = 0.011
Identities = 26/92 (28%), Positives = 43/92 (46%), Gaps = 1/92 (1%)
Frame = +1
Query: 7 GYQKRTVTCEKIEAQYYKIVDDRFCLNT-KPITIKHCKSSALCPSWKVEKSDNFQCSDVC 183
G Q R V+C + + D+ C + +P + C S C W+ D CS C
Sbjct: 1167 GSQARYVSCRDAHDE---VADESNCAHLPRPAAVSLCFSP--CGEWQA--GDWSPCSASC 1219
Query: 184 VNVGVAKTNTKIICQHNNKTVDSSFCDRDKQP 279
G KT +++C + ++ VD S+CD + +P
Sbjct: 1220 ---GHGKTTRRVLCVNYHQLVDESYCDPEGRP 1248
Score = 33.5 bits (75), Expect = 0.46
Identities = 34/137 (24%), Positives = 55/137 (40%), Gaps = 21/137 (15%)
Frame = +1
Query: 7 GYQKRTVTCEKIEAQYYKIVDDRFC-LNTKPITIKHCKSSALCPSWKVEKSDNFQCSDVC 183
G ++R V C+ E + D FC +TKP +++ C+ A C SW V + C+ C
Sbjct: 1036 GMKQRQVWCQLSEDP----MRDGFCNASTKPESLRPCELRA-CASWHVGPWGS--CTATC 1088
Query: 184 VNVGVAKTNTKIICQHNNKTVDSSFCDRDKQPS----------ITCPNTNCDVL------ 315
+ G K I + +D C + +PS + P L
Sbjct: 1089 GH-GYQMRAVKCISEIFGTMLDDRECPQASRPSDRQDCILAPCLAIPEVGATSLPAIPLG 1147
Query: 316 ----YEYGLWSQCSMSC 354
+ +G W+ CS+SC
Sbjct: 1148 RAAQWRHGSWTPCSVSC 1164
Score = 32.0 bits (71), Expect = 1.4
Identities = 30/114 (26%), Positives = 47/114 (41%), Gaps = 10/114 (8%)
Frame = +1
Query: 88 TKPITIKHCKSSALCPSWKVEKSDNFQCSDVCVNVGVAKTN--TKIICQ-----HNNKTV 246
TKP++IK C++ + V D+ QC+ C K TKI H + V
Sbjct: 1570 TKPLSIKKCRNPHC--KYSVVTGDSSQCAGNCGFTSPQKITYCTKIQSSKKHTFHQLRPV 1627
Query: 247 DSSFCDRDKQP-SITCPNTNC--DVLYEYGLWSQCSMSCSNTTNVSIRSRTMKC 399
C P + C +C ++ G WS+CS++C + I R + C
Sbjct: 1628 VYGECPVIPSPQAYKCDLRSCLHVATWKVGKWSKCSVTC----GIGIMERRVAC 1677
>sp|Q9H324|ATS10_HUMAN ADAMTS-10 precursor (A disintegrin and metalloproteinase with
thrombospondin motifs 10) (ADAM-TS 10) (ADAM-TS10)
Length = 1077
Score = 53.5 bits (127), Expect = 4e-07
Identities = 53/209 (25%), Positives = 83/209 (39%), Gaps = 14/209 (6%)
Frame = +1
Query: 7 GYQKRTVTCEK-IEAQYYKIVDDRFCLNTKPITIKHCKSSALCPSWKVEKSDNFQCSDVC 183
G + R+V C++ + A K +DD C +P ++ C P W D +C+ C
Sbjct: 877 GVRSRSVVCQRRVSAAEEKALDDSACPQPRPPVLEACHGPTCPPEWAA--LDWSECTPSC 934
Query: 184 VNVGVAKTNTKIICQ--HNNKTVDSSFCDRDKQPSIT--CPNTNC-DVLYEYGLWSQCSM 348
G + ++C+ + T+ + C +P T C C + G W +CS
Sbjct: 935 ---GPGLRHRVVLCKSADHRATLPPAHCSPAAKPPATMRCNLRRCPPARWVAGEWGECSA 991
Query: 349 SCSNTTNVSIRSRTMKCIWKHTKKPAYHLC--QLHQVNRERLTKSCRVPKCILG---CKD 513
C V R R+++C HT + A H C L ++ C P G CKD
Sbjct: 992 QC----GVGQRQRSVRCT-SHTGQ-ASHECTEALRPPTTQQCEAKCDSPTPGDGPEECKD 1045
Query: 514 LTPA--CVKQSKFR-CQSSLFTHFCCAFC 591
+ C KF+ C + F CC C
Sbjct: 1046 VNKVAYCPLVLKFQFCSRAYFRQMCCKTC 1074
>sp|P59509|ATS19_MOUSE ADAMTS-19 precursor (A disintegrin and metalloproteinase with
thrombospondin motifs 19) (ADAM-TS 19) (ADAM-TS19)
Length = 1210
Score = 50.1 bits (118), Expect = 5e-06
Identities = 38/137 (27%), Positives = 63/137 (45%), Gaps = 6/137 (4%)
Frame = +1
Query: 7 GYQKRTVTCEKIEAQYYKIVDDRFCLN-TKPIT-IKHCKSSALCPSWKVEKSDNFQCSDV 180
G +K V+C KI ++ +VD++ C + TKP I+ C W + + CS
Sbjct: 937 GERKTMVSCTKIMSKNISLVDNKKCKDLTKPEPQIRKCNEQPCQTRWMMTEWTT--CSRT 994
Query: 181 CVNVGVAKTNTKIICQHNNKTVDSSF---CDRDKQPSIT-CPNTNCDVLYEYGLWSQCSM 348
C GV Q N T+ ++ C K ++ C +C ++E G+WS+CS+
Sbjct: 995 C-GKGVQSRQVACTQQLENGTLIRAWERDCLGPKPATVQRCEGQDCMTVWEAGVWSECSV 1053
Query: 349 SCSNTTNVSIRSRTMKC 399
C +R RT++C
Sbjct: 1054 KCGK----GVRHRTVRC 1066
Score = 49.3 bits (116), Expect = 8e-06
Identities = 53/214 (24%), Positives = 83/214 (38%), Gaps = 19/214 (8%)
Frame = +1
Query: 7 GYQKRTVTC-EKIEAQYYKIVDDRFCLNTKPITIKHCKSSALCPSWKVEKSDNFQCSDVC 183
G Q R V C +++E +R CL KP T++ C+ W E +CS C
Sbjct: 998 GVQSRQVACTQQLENGTLIRAWERDCLGPKPATVQRCEGQDCMTVW--EAGVWSECSVKC 1055
Query: 184 VNVGVAKTNTKIICQHNNKTVDSSFCDRDKQPSITCPNTNCDVLYEYGLWSQCSMSCSNT 363
G + + C + K S R+ + C + + ++ G WS+CS++C
Sbjct: 1056 ---GKGVRHRTVRCTNPRKKCVLSTRpreAED---CEDYSKCYVWRVGDWSKCSITCGK- 1108
Query: 364 TNVSIRSRTMKCIWKHT-----------KKPAYHLCQLHQVNRERLTKSCRVP------- 489
++SR ++C+ K T K AY C L N + + P
Sbjct: 1109 ---GMQSRVIQCMHKITGRHGNECFSSEKPAAYRPCHLQPCNEKINVNTITSPRLAALTF 1165
Query: 490 KCILGCKDLTPACVKQSKFRCQSSLFTHFCCAFC 591
KC LG + V + K CQ + CC C
Sbjct: 1166 KC-LGDQWPVYCRVIREKNLCQDMRWYQRCCETC 1198
>sp|P59510|ATS20_HUMAN ADAMTS-20 precursor (A disintegrin and metalloproteinase with
thrombospondin motifs 20) (ADAM-TS 20) (ADAM-TS20)
Length = 1911
Score = 49.3 bits (116), Expect = 8e-06
Identities = 60/214 (28%), Positives = 86/214 (40%), Gaps = 18/214 (8%)
Frame = +1
Query: 7 GYQKRTVTCEKIEAQYYKIVDDRFC--LNTKPITIKHCKSSALCPSWKVEKSDNFQCSDV 180
G Q+R +TC I + +V D+ C L + C + + K +CS
Sbjct: 865 GLQRRNITC--IHKSDHSVVSDKECDHLPLPSFVTQSCNTDCELRGMLLAKKS--ECSSQ 920
Query: 181 CVNVGVAKTNTKIICQ----HNNKTV--DSSFC-DRDKQPSITCPNTNCDVL-YEYGLWS 336
C G I C H +TV D +C D+ K P+ + NC + Y WS
Sbjct: 921 C---GQGYRTLDIHCMKYSIHEGQTVQVDDHYCGDQLKPPTQELCHGNCVFTRWHYSEWS 977
Query: 337 QCSMSCSNTTNVSIRSRTMKCIWKHTKKPAYHLCQ-LHQVNRERLTK-SC------RVPK 492
QCS SC RSR C+ + A + CQ L +V RE + SC +
Sbjct: 978 QCSRSCGG----GERSRESYCMNNFGHRLADNECQELSRVTRENCNEFSCPSWAASEWSE 1033
Query: 493 CILGCKDLTPACVKQSKFRCQSSLFTHFCCAFCN 594
C++ C T KQ + CQ ++ H FCN
Sbjct: 1034 CLVTCGKGT----KQRQVWCQLNV-DHLSDGFCN 1062
Score = 40.8 bits (94), Expect = 0.003
Identities = 44/171 (25%), Positives = 66/171 (38%), Gaps = 8/171 (4%)
Frame = +1
Query: 7 GYQKRTVTCEKIEAQYYKIVDDRFCLNTKPITIKHCKSSALCPSWKVEKSDNFQCSDVCV 186
G Q V C+ Q D +KP ++ C CP W +CS C
Sbjct: 1324 GLQHTAVVCQDENGQSASYCDAA----SKPPELQQCGPGP-CPQWNYGNWG--ECSQTC- 1375
Query: 187 NVGVAKTNTKIICQH-NNKTVDSSFCDR-DKQPSI------TCPNTNCDVLYEYGLWSQC 342
G + +ICQ N + ++ C+ +K PS+ CP DV + W+ C
Sbjct: 1376 --GGGIKSRLVICQFPNGQILEDHNCEIVNKPPSVIQCHMHACP---ADVSWHQEPWTSC 1430
Query: 343 SMSCSNTTNVSIRSRTMKCIWKHTKKPAYHLCQLHQVNRERLTKSCRVPKC 495
S SC + R + CI + +K C QV + K+CR +C
Sbjct: 1431 SASCGK----GRKYREVFCIDQFQRKLEDTNCS--QVQKPPTHKACRSVRC 1475
Score = 38.5 bits (88), Expect = 0.014
Identities = 30/116 (25%), Positives = 47/116 (40%), Gaps = 7/116 (6%)
Frame = +1
Query: 169 CSDVCVNVGVAKTNTKIICQHNNKTVDSSFCDRDKQPSIT-------CPNTNCDVLYEYG 327
CS C +T ++CQ N +S+CD +P CP N YG
Sbjct: 1317 CSSSCSG---GLQHTAVVCQDENGQ-SASYCDAASKPPELQQCGPGPCPQWN------YG 1366
Query: 328 LWSQCSMSCSNTTNVSIRSRTMKCIWKHTKKPAYHLCQLHQVNRERLTKSCRVPKC 495
W +CS +C I+SR + C + + + H C++ VN+ C + C
Sbjct: 1367 NWGECSQTCGG----GIKSRLVICQFPNGQILEDHNCEI--VNKPPSVIQCHMHAC 1416
Score = 38.1 bits (87), Expect = 0.019
Identities = 25/92 (27%), Positives = 44/92 (47%), Gaps = 1/92 (1%)
Frame = +1
Query: 7 GYQKRTVTCEKIEAQYYKIVDDRFCLNT-KPITIKHCKSSALCPSWKVEKSDNFQCSDVC 183
G Q R V+C +I D+ +C + +P I C + C W+ D CS C
Sbjct: 1172 GTQARYVSCRDA---LDRIADESYCAHLPRPAEIWDCFTP--CGEWQA--GDWSPCSASC 1224
Query: 184 VNVGVAKTNTKIICQHNNKTVDSSFCDRDKQP 279
G KT +++C + ++ +D ++CD + +P
Sbjct: 1225 ---GHGKTTRQVLCMNYHQPIDENYCDPEVRP 1253
Score = 35.4 bits (80), Expect = 0.12
Identities = 40/162 (24%), Positives = 62/162 (38%), Gaps = 13/162 (8%)
Frame = +1
Query: 49 QYYKIVDDRFCLNT-KPITIKHCKSSALCPSWKVEKSDNFQCSDVCVNVGVAKTNTKIIC 225
Q+ + ++D C KP T K C+S CPSWK + +CS C G + C
Sbjct: 1448 QFQRKLEDTNCSQVQKPPTHKACRS-VRCPSWKANSWN--ECSVTC---GSGVQQRDVYC 1501
Query: 226 QHNN-KTVDSSFCDRDKQPSITCPNTNC---DVLYEYGLWSQCSMSCSNTTNVSIRSRTM 393
+ V CD+ +P C C D + G+ + ++CS + + M
Sbjct: 1502 RLKGVGQVVEEMCDQSTRP---CSQRRCWSQDCVQHKGM-ERGRLNCSTSCERKDSHQRM 1557
Query: 394 KCIWKHTKKPAYHLCQLHQVNR--------ERLTKSCRVPKC 495
+C Q+ QVN +K+CR P C
Sbjct: 1558 ECTDN----------QIRQVNEIVYNSSTISLTSKNCRNPPC 1589
Score = 33.1 bits (74), Expect = 0.61
Identities = 32/141 (22%), Positives = 59/141 (41%), Gaps = 21/141 (14%)
Frame = +1
Query: 7 GYQKRTVTCEKIEAQYYKIVDDRFC-LNTKPITIKHCKSSALCPSWKVEKSDNFQCSDVC 183
G ++R V C+ + + + D FC +TKP ++ C+ C SW+V C+ C
Sbjct: 1041 GTKQRQVWCQ-LNVDH---LSDGFCNSSTKPESLSPCELHT-CASWQVGPWG--PCTTTC 1093
Query: 184 VNVGVAKTNTKIICQHNNKTVDSSFCDRDKQPSI--TCPNTNCDVL-------------- 315
+ G + K + + + ++ + C +PS +C T C +
Sbjct: 1094 GH-GYQMRDVKCVNELASAVLEDTECHEASRPSDRQSCVLTPCSFISKLETALLPTVLIK 1152
Query: 316 ----YEYGLWSQCSMSCSNTT 366
+ +G W+ CS+SC T
Sbjct: 1153 KMAQWRHGSWTPCSVSCGRGT 1173
Score = 32.3 bits (72), Expect = 1.0
Identities = 28/118 (23%), Positives = 52/118 (44%), Gaps = 9/118 (7%)
Frame = +1
Query: 85 NTKPITIKHCKSSALCPSWKVEKSDNFQCSDVC-------VNVGVAKTNTKIICQHNNKT 243
+T +T K+C++ ++ V +D+ QC++ C + +TK H +
Sbjct: 1575 STISLTSKNCRNPPC--NYIVVTADSSQCANNCGFSYRQRITYCTEIPSTKKHKLHRLRP 1632
Query: 244 VDSSFCDRDKQPSITCPNTNCDVL--YEYGLWSQCSMSCSNTTNVSIRSRTMKCIWKH 411
+ C + +C L ++ G WS+CS++C + I R +KCI KH
Sbjct: 1633 IVYQECPVVPSSQVYQCINSCLHLATWKVGKWSKCSVTCG----IGIMKRQVKCITKH 1686
>sp|Q4VC17|ATS18_MOUSE ADAMTS-18 precursor (A disintegrin and metalloproteinase with
thrombospondin motifs 18) (ADAM-TS 18) (ADAM-TS18)
Length = 1219
Score = 47.4 bits (111), Expect = 3e-05
Identities = 38/143 (26%), Positives = 59/143 (41%), Gaps = 9/143 (6%)
Frame = +1
Query: 7 GYQKRTVTC-EKIEAQYYKIVDDRFCLNTKPITIKHCKSSALCPSWKVEKSDNFQCSDVC 183
G Q R + C +K Q + V C + P ++ C S A P W S QCS C
Sbjct: 950 GQQSRKIRCVQKKPFQKEEAVLHSLCPVSTPTQVQVCNSHACPPEWS--PSPWSQCSKTC 1007
Query: 184 VNVGVAKTNTKIICQHNN-KTVDSSFCDRDKQPSIT-------CPNTNCDVLYEYGLWSQ 339
G +++C+ +T+ S C +P CP N + + WS+
Sbjct: 1008 ---GRGVRRREVLCKSPAAETLPESLCSSSPRPEAQEGCVLGRCPKNN-RLQWIASAWSE 1063
Query: 340 CSMSCSNTTNVSIRSRTMKCIWK 408
CS +C + +R R +KC+ K
Sbjct: 1064 CSATCG----LGVRKRELKCVEK 1082
Score = 41.6 bits (96), Expect = 0.002
Identities = 30/95 (31%), Positives = 45/95 (47%), Gaps = 4/95 (4%)
Frame = +1
Query: 136 SWKVEKSDNFQCSDVCVNVGVAKTNTKIICQHNNKT-VDSSFCDRDKQPSIT---CPNTN 303
+W+ +SD CS C G + K IC + T V+SSFC +P+ C +
Sbjct: 877 TWRTVQSD---CSVTC---GGGYISIKAICLRDQHTQVNSSFCSVRTKPATEPKICNAFS 930
Query: 304 CDVLYEYGLWSQCSMSCSNTTNVSIRSRTMKCIWK 408
C + G WS CS SC+ +SR ++C+ K
Sbjct: 931 CPAYWLPGEWSACSKSCAG----GQQSRKIRCVQK 961
>sp|O15072|ATS3_HUMAN ADAMTS-3 precursor (A disintegrin and metalloproteinase with
thrombospondin motifs 3) (ADAM-TS 3) (ADAM-TS3)
(Procollagen II amino propeptide-processing enzyme)
(Procollagen II N-proteinase) (PC II-NP)
Length = 1205
Score = 47.4 bits (111), Expect = 3e-05
Identities = 45/192 (23%), Positives = 78/192 (40%), Gaps = 11/192 (5%)
Frame = +1
Query: 58 KIVDDRFC-LNTKPITIKHCKSSALC--PSWKVEKSDNFQCSDVCVNVGVAKTNTKII-- 222
K+V FC N KP I+ + C P W E+ ++ C+ C + G + +
Sbjct: 879 KMVHRSFCEANKKPKPIRRMCNIQECTHPLWVAEEWEH--CTKTCGSSGYQLRTVRCLQP 936
Query: 223 -CQHNNKTVDSSFCDRDKQPSIT-CPNTNCDVLYEYGLWSQCSMSCSNTTNVSIRSRTMK 396
N++V S +C D+ S C C ++ G WS+CS++C T V R +
Sbjct: 937 LLDGTNRSVHSKYCMGDRPESRRPCNRVPCPAQWKTGPWSECSVTCGEGTEV----RQVL 992
Query: 397 CIWKHTKKPAYHLCQLHQVNRERLTKSCRVPKC----ILGCKDLTPACVKQSKFRCQSSL 564
C + H + ++C++P C LG K + +++ C
Sbjct: 993 C------RAGDHC----DGEKPESVRACQLPPCNDEPCLGDKSIFCQMEVLARY-CSIPG 1041
Query: 565 FTHFCCAFCNKQ 600
+ CC C+K+
Sbjct: 1042 YNKLCCESCSKR 1053
Score = 29.6 bits (65), Expect = 6.7
Identities = 20/70 (28%), Positives = 34/70 (48%), Gaps = 6/70 (8%)
Frame = +1
Query: 211 TKIICQH--NNKTVDSSFCDRDKQPS---ITCPNTNC-DVLYEYGLWSQCSMSCSNTTNV 372
TK C+ +NK V SFC+ +K+P C C L+ W C+ +C ++
Sbjct: 868 TKYGCRRKSDNKMVHRSFCEANKKPKPIRRMCNIQECTHPLWVAEEWEHCTKTCGSS--- 924
Query: 373 SIRSRTMKCI 402
+ RT++C+
Sbjct: 925 GYQLRTVRCL 934
>sp|P58459|ATS10_MOUSE ADAMTS-10 (A disintegrin and metalloproteinase with thrombospondin
motifs 10) (ADAM-TS 10) (ADAM-TS10)
Length = 450
Score = 45.8 bits (107), Expect = 9e-05
Identities = 49/213 (23%), Positives = 81/213 (38%), Gaps = 18/213 (8%)
Frame = +1
Query: 7 GYQKRTVTCEK-IEAQYYKIVDDRFCLNTKPITIKHCKSSALCPSWKVEKSDNFQCSDVC 183
G + R+V C++ + A K +DD C +P ++ C+ P W D +C+ C
Sbjct: 249 GVRSRSVVCQRRVSAAEEKALDDSACPQPRPPVLEACQGPMCPPEWAT--LDWSECTPSC 306
Query: 184 VNVGVAKTNTKIICQ--HNNKTVDSSFCDRDKQPSIT--CPNTNC-DVLYEYGLWSQCSM 348
G + ++C+ T+ C +P T C C + W +CS
Sbjct: 307 ---GPGLRHRVVLCKSADQRSTLPPGHCLPAAKPPSTMRCNLRRCPPARWVTSEWGECST 363
Query: 349 SCSNTTNVSIRSRTMKCIWKHTKKPAYHLCQLHQVNRERLTKSCRVPKCIL--------- 501
C + + RT++C HT +P+ + + R + C KC
Sbjct: 364 QC----GLGQQQRTVRCT-SHTGQPSR---ECTEALRPSTMQQCEA-KCDSVVPPGDGPE 414
Query: 502 GCKDLTPA--CVKQSKFR-CQSSLFTHFCCAFC 591
CKD+ C KF+ C + F CC C
Sbjct: 415 ECKDVNKVAYCPLVLKFQFCSRAYFRQMCCKTC 447
>sp|Q8TE59|ATS19_HUMAN ADAMTS-19 precursor (A disintegrin and metalloproteinase with
thrombospondin motifs 19) (ADAM-TS 19) (ADAM-TS19)
Length = 1207
Score = 45.8 bits (107), Expect = 9e-05
Identities = 41/139 (29%), Positives = 63/139 (45%), Gaps = 8/139 (5%)
Frame = +1
Query: 7 GYQKRTVTCEKIEAQYYKIVDDRFC-LNTKP-ITIKHCKSSALCPSWKVEKSDNFQCSDV 180
G +K TV+C KI ++ IVD+ C TKP I+ C W + ++ CS
Sbjct: 934 GERKTTVSCTKIMSKNISIVDNEKCKYLTKPEPQIRKCNEQPCQTRWMM--TEWTPCSRT 991
Query: 181 CVNVGVAKTNTKIIC--QHNNKTV---DSSFCDRDKQPSI-TCPNTNCDVLYEYGLWSQC 342
C G + ++ C Q +N T+ C K S C +C ++E G+WS+
Sbjct: 992 C---GKGMQSRQVACTQQLSNGTLIRARERDCIGPKPASAQRCEGQDCMTVWEAGVWSEF 1048
Query: 343 SMSCSNTTNVSIRSRTMKC 399
S+ C IR RT++C
Sbjct: 1049 SVKCGK----GIRHRTVRC 1063
Score = 43.9 bits (102), Expect = 3e-04
Identities = 49/214 (22%), Positives = 79/214 (36%), Gaps = 19/214 (8%)
Frame = +1
Query: 7 GYQKRTVTCEKIEAQYYKI-VDDRFCLNTKPITIKHCKSSALCPSWKVEKSDNFQCSDVC 183
G Q R V C + + I +R C+ KP + + C+ W+ F
Sbjct: 995 GMQSRQVACTQQLSNGTLIRARERDCIGPKPASAQRCEGQDCMTVWEAGVWSEFS----- 1049
Query: 184 VNVGVAKTNTKIICQHNNKTVDSSFCDRDKQPSITCPNTNCDVLYEYGLWSQCSMSCSNT 363
V G + + C + K S R+ + C + + ++ G WS+CS++C
Sbjct: 1050 VKCGKGIRHRTVRCTNPRKKCVLSTRpreAED---CEDYSKCYVWRMGDWSKCSITCGK- 1105
Query: 364 TNVSIRSRTMKCIWKHT-----------KKPAYHLCQLHQVNRERLTKSCRVP------- 489
++SR ++C+ K T K AY C L N + + P
Sbjct: 1106 ---GMQSRVIQCMHKITGRHGNECFSSEKPAAYRPCHLQPCNEKINVNTITSPRLAALTF 1162
Query: 490 KCILGCKDLTPACVKQSKFRCQSSLFTHFCCAFC 591
KC LG + V + K CQ + CC C
Sbjct: 1163 KC-LGDQWPVYCRVIREKNLCQDMRWYQRCCETC 1195
>sp|O95450|ATS2_HUMAN ADAMTS-2 precursor (A disintegrin and metalloproteinase with
thrombospondin motifs 2) (ADAM-TS 2) (ADAM-TS2)
(Procollagen I/II amino propeptide-processing enzyme)
(Procollagen I N-proteinase) (PC I-NP) (Procollagen
N-endopeptidase) (pNPI)
Length = 1211
Score = 45.4 bits (106), Expect = 1e-04
Identities = 42/155 (27%), Positives = 67/155 (43%), Gaps = 8/155 (5%)
Frame = +1
Query: 55 YKIVDDRFCLN-TKPITIKHCKSSALC--PSWKVEKSDNFQCSDVCVNVGVAKTNTKIIC 225
+K+V FC +KP I+ + C P W + + CS C G+ + + I
Sbjct: 887 HKMVHRGFCAALSKPKAIRRACNPQECSQPVWVTGEWE--PCSQTCGRTGMQVRSVRCIQ 944
Query: 226 Q-HNNKT--VDSSFCDRDKQPSI--TCPNTNCDVLYEYGLWSQCSMSCSNTTNVSIRSRT 390
H+N T V + C+ D +P C C + G WSQCS++C N T + R
Sbjct: 945 PLHDNTTRSVHAKHCN-DARPESRRACSRELCPGRWRAGPWSQCSVTCGNGT----QERP 999
Query: 391 MKCIWKHTKKPAYHLCQLHQVNRERLTKSCRVPKC 495
+ C T ++ +C Q R ++CR+ C
Sbjct: 1000 VPC---RTADDSFGIC---QEERPETARTCRLGPC 1028
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 75,805,362
Number of Sequences: 369166
Number of extensions: 1541251
Number of successful extensions: 3937
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 3682
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 3900
length of database: 68,354,980
effective HSP length: 106
effective length of database: 48,773,070
effective search space used: 5072399280
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)