Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_026_L01
(810 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q9CPP7|LIPG_MOUSE Gastric triacylglycerol lipase precurs... 233 5e-61
sp|P80035|LIPG_CANFA Gastric triacylglycerol lipase precurs... 231 1e-60
sp|P07098|LIPG_HUMAN Gastric triacylglycerol lipase precurs... 229 5e-60
sp|P04634|LIPG_RAT Gastric triacylglycerol lipase precursor... 228 1e-59
sp|Q9Z0M5|LICH_MOUSE Lysosomal acid lipase/cholesteryl este... 226 7e-59
sp|P38571|LICH_HUMAN Lysosomal acid lipase/cholesteryl este... 222 1e-57
sp|Q29458|LIPG_BOVIN Gastric triacylglycerol lipase precurs... 220 3e-57
sp|Q64194|LICH_RAT Lysosomal acid lipase/cholesteryl ester ... 207 4e-53
sp|O46108|LIP3_DROME Lipase 3 precursor (DmLip3) 172 1e-42
sp|O46107|LIP1_DROME Lipase 1 precursor (DmLip1) 168 1e-41
>sp|Q9CPP7|LIPG_MOUSE Gastric triacylglycerol lipase precursor (Gastric lipase) (GL)
Length = 395
Score = 233 bits (594), Expect = 5e-61
Identities = 121/264 (45%), Positives = 166/264 (62%)
Frame = +1
Query: 19 DPEVKMNISEIIRYNGYPCEDHRVVTKDGYILSMQRIPFGSKTRERQTKMTQSRPVVLLQ 198
+PE MN+S++I Y GYP E++ VVT+DGYIL + RIP+G K E K RPV LQ
Sbjct: 27 NPEANMNVSQMITYWGYPSEEYEVVTEDGYILGVYRIPYGKKNSENIGK----RPVAYLQ 82
Query: 199 HGLLDSAHTWAINSPEQSLAFILADHGFDVWLANSRGNTYSNKHVSLNERDPKFWEFSWD 378
HGL+ SA W N P SLAFILAD G+DVWL NSRGNT+S K+V + +FW FS+D
Sbjct: 83 HGLIASATNWITNLPNNSLAFILADAGYDVWLGNSRGNTWSRKNVYYSPDSVEFWAFSFD 142
Query: 379 EMASFDLPACVDYALKISGNATKLTYIGHSQGTEIAFAQFSQDVLLRKKISSYVALAPAV 558
EMA +DLPA +D+ ++ +G K+ Y+GHSQGT I F FS + L KKI + ALAP
Sbjct: 143 EMAKYDLPATIDFIVQKTGQ-EKIHYVGHSQGTTIGFIAFSTNPALAKKIKRFYALAPVA 201
Query: 559 FLGNVEAGLRILARFREDIETLLNLFGHGRVMSNSEIFKFLASTICGKEGLPKFCSEVIF 738
+ E+ + ++ + + L +FG+ M ++ + +FL + +C +E L CS +F
Sbjct: 202 TVKYTESPFKKISLIPKFL--LKVIFGNKMFMPHNYLDQFLGTEVCSRELLDLLCSNALF 259
Query: 739 LLAGHDIKNLNESRLPVYISHTPA 810
+ G D KNLN SR VY+ H PA
Sbjct: 260 IFCGFDKKNLNVSRFDVYLGHNPA 283
>sp|P80035|LIPG_CANFA Gastric triacylglycerol lipase precursor (Gastric lipase) (GL)
Length = 398
Score = 231 bits (590), Expect = 1e-60
Identities = 124/264 (46%), Positives = 165/264 (62%)
Frame = +1
Query: 19 DPEVKMNISEIIRYNGYPCEDHRVVTKDGYILSMQRIPFGSKTRERQTKMTQSRPVVLLQ 198
+PEV MNIS++I Y GYP E++ VVT+DGYIL + RIP+G K E + RPV LQ
Sbjct: 28 NPEVTMNISQMITYWGYPAEEYEVVTEDGYILGIDRIPYGRKNSENIGR----RPVAFLQ 83
Query: 199 HGLLDSAHTWAINSPEQSLAFILADHGFDVWLANSRGNTYSNKHVSLNERDPKFWEFSWD 378
HGLL SA W N P SLAFILAD G+DVWL NSRGNT++ +++ + +FW FS+D
Sbjct: 84 HGLLASATNWISNLPNNSLAFILADAGYDVWLGNSRGNTWARRNLYYSPDSVEFWAFSFD 143
Query: 379 EMASFDLPACVDYALKISGNATKLTYIGHSQGTEIAFAQFSQDVLLRKKISSYVALAPAV 558
EMA +DLPA +D+ LK +G KL Y+GHSQGT I F FS + L K+I ++ ALAP
Sbjct: 144 EMAKYDLPATIDFILKKTGQ-DKLHYVGHSQGTTIGFIAFSTNPKLAKRIKTFYALAPVA 202
Query: 559 FLGNVEAGLRILARFREDIETLLNLFGHGRVMSNSEIFKFLASTICGKEGLPKFCSEVIF 738
+ E L L + L +FG+ + +FLA+ +C +E + CS +F
Sbjct: 203 TVKYTETLLNKLMLVPSFLFKL--IFGNKIFYPHHFFDQFLATEVCSRETVDLLCSNALF 260
Query: 739 LLAGHDIKNLNESRLPVYISHTPA 810
++ G D NLN SRL VY+SH PA
Sbjct: 261 IICGFDTMNLNMSRLDVYLSHNPA 284
>sp|P07098|LIPG_HUMAN Gastric triacylglycerol lipase precursor (Gastric lipase) (GL)
Length = 398
Score = 229 bits (585), Expect = 5e-60
Identities = 123/264 (46%), Positives = 168/264 (63%), Gaps = 1/264 (0%)
Frame = +1
Query: 22 PEVKMNISEIIRYNGYPCEDHRVVTKDGYILSMQRIPFGSKTRERQTKMTQSRPVVLLQH 201
PEV MNIS++I Y GYP E++ VVT+DGYIL + RIP+G K T RPVV LQH
Sbjct: 29 PEVTMNISQMITYWGYPNEEYEVVTEDGYILEVNRIPYGKKNSGN----TGQRPVVFLQH 84
Query: 202 GLLDSAHTWAINSPEQSLAFILADHGFDVWLANSRGNTYSNKHVSLNERDPKFWEFSWDE 381
GLL SA W N P SLAFILAD G+DVWL NSRGNT++ +++ + +FW FS+DE
Sbjct: 85 GLLASATNWISNLPNNSLAFILADAGYDVWLGNSRGNTWARRNLYYSPDSVEFWAFSFDE 144
Query: 382 MASFDLPACVDYALKISGNATKLTYIGHSQGTEIAFAQFSQDVLLRKKISSYVALAPAVF 561
MA +DLPA +D+ +K +G +L Y+GHSQGT I F FS + L K+I ++ ALAP
Sbjct: 145 MAKYDLPATIDFIVKKTGQ-KQLHYVGHSQGTTIGFIAFSTNPSLAKRIKTFYALAP--- 200
Query: 562 LGNVEAGLRILARFREDIETLLN-LFGHGRVMSNSEIFKFLASTICGKEGLPKFCSEVIF 738
+ V+ ++ + R ++L +FG ++ +FLA+ +C +E L CS +F
Sbjct: 201 VATVKYTKSLINKLRFVPQSLFKFIFGDKIFYPHNFFDQFLATEVCSREMLNLLCSNALF 260
Query: 739 LLAGHDIKNLNESRLPVYISHTPA 810
++ G D KN N SRL VY+SH PA
Sbjct: 261 IICGFDSKNFNTSRLDVYLSHNPA 284
>sp|P04634|LIPG_RAT Gastric triacylglycerol lipase precursor (Gastric lipase) (GL)
(Lingual lipase)
Length = 395
Score = 228 bits (582), Expect = 1e-59
Identities = 119/264 (45%), Positives = 164/264 (62%)
Frame = +1
Query: 19 DPEVKMNISEIIRYNGYPCEDHRVVTKDGYILSMQRIPFGSKTRERQTKMTQSRPVVLLQ 198
+PE MNIS++I Y GYPC+++ VVT+DGYIL + RIP G E K RPVV LQ
Sbjct: 27 NPEANMNISQMITYWGYPCQEYEVVTEDGYILGVYRIPHGKNNSENIGK----RPVVYLQ 82
Query: 199 HGLLDSAHTWAINSPEQSLAFILADHGFDVWLANSRGNTYSNKHVSLNERDPKFWEFSWD 378
HGL+ SA W N P SLAF+LAD G+DVWL NSRGNT+S K+V + +FW FS+D
Sbjct: 83 HGLIASATNWIANLPNNSLAFMLADAGYDVWLGNSRGNTWSRKNVYYSPDSVEFWAFSFD 142
Query: 379 EMASFDLPACVDYALKISGNATKLTYIGHSQGTEIAFAQFSQDVLLRKKISSYVALAPAV 558
EMA +DLPA +++ ++ +G K+ Y+GHSQGT I F FS + L KKI ++ ALAP
Sbjct: 143 EMAKYDLPATINFIVQKTGQ-EKIHYVGHSQGTTIGFIAFSTNPTLAKKIKTFYALAPVA 201
Query: 559 FLGNVEAGLRILARFREDIETLLNLFGHGRVMSNSEIFKFLASTICGKEGLPKFCSEVIF 738
+ ++ L+ ++ + L +FG + ++ FL + +C +E L CS +F
Sbjct: 202 TVKYTQSPLKKISFIPTFLFKL--MFGKKMFLPHTYFDDFLGTEVCSREVLDLLCSNTLF 259
Query: 739 LLAGHDIKNLNESRLPVYISHTPA 810
+ G D KNLN SR VY+ H PA
Sbjct: 260 IFCGFDKKNLNVSRFDVYLGHNPA 283
>sp|Q9Z0M5|LICH_MOUSE Lysosomal acid lipase/cholesteryl ester hydrolase precursor (LAL)
(Acid cholesteryl ester hydrolase) (Sterol esterase)
(Lipase A) (Cholesteryl esterase)
Length = 397
Score = 226 bits (575), Expect = 7e-59
Identities = 123/268 (45%), Positives = 165/268 (61%)
Frame = +1
Query: 7 VTSVDPEVKMNISEIIRYNGYPCEDHRVVTKDGYILSMQRIPFGSKTRERQTKMTQSRPV 186
V++VDPEV MN++EII GYP E+H V+T DGYILS+ RIP G K + RPV
Sbjct: 24 VSAVDPEVNMNVTEIIMRWGYPGEEHSVLTGDGYILSIHRIPRGWKNHFGKGP----RPV 79
Query: 187 VLLQHGLLDSAHTWAINSPEQSLAFILADHGFDVWLANSRGNTYSNKHVSLNERDPKFWE 366
V LQHGLL + W N SL F+LAD GFDVW+ NSRGNT+S KH +L+ +FW
Sbjct: 80 VYLQHGLLADSSNWVTNIDNSSLGFLLADRGFDVWMGNSRGNTWSLKHKTLSVSQDEFWA 139
Query: 367 FSWDEMASFDLPACVDYALKISGNATKLTYIGHSQGTEIAFAQFSQDVLLRKKISSYVAL 546
FS+DEMA +DLPA ++Y L +G ++ Y+GHSQG I F FSQ L KKI ++ L
Sbjct: 140 FSFDEMAKYDLPASINYILNKTGQ-EQIYYVGHSQGCTIGFIAFSQMPELAKKIKMFLVL 198
Query: 547 APAVFLGNVEAGLRILARFREDIETLLNLFGHGRVMSNSEIFKFLASTICGKEGLPKFCS 726
AP + L L L R + + L ++FG + + S + K+L+ +C + + C+
Sbjct: 199 APVLSLNFASGPLLQLGRLPDPL--LKDMFGQKQFLPQSAMLKWLSIHVCTHVIMKELCA 256
Query: 727 EVIFLLAGHDIKNLNESRLPVYISHTPA 810
V FLL G + KNLN SR+ VY +H PA
Sbjct: 257 NVFFLLCGFNEKNLNMSRVDVYTTHCPA 284
>sp|P38571|LICH_HUMAN Lysosomal acid lipase/cholesteryl ester hydrolase precursor (LAL)
(Acid cholesteryl ester hydrolase) (Sterol esterase)
(Lipase A) (Cholesteryl esterase)
Length = 399
Score = 222 bits (565), Expect = 1e-57
Identities = 117/268 (43%), Positives = 162/268 (60%)
Frame = +1
Query: 7 VTSVDPEVKMNISEIIRYNGYPCEDHRVVTKDGYILSMQRIPFGSKTRERQTKMTQSRPV 186
+T+VDPE MN+SEII Y G+P E++ V T+DGYIL + RIP G K + +PV
Sbjct: 26 LTAVDPETNMNVSEIISYWGFPSEEYLVETEDGYILCLNRIPHGRKNHSDKGP----KPV 81
Query: 187 VLLQHGLLDSAHTWAINSPEQSLAFILADHGFDVWLANSRGNTYSNKHVSLNERDPKFWE 366
V LQHGLL + W N SL FILAD GFDVW+ NSRGNT+S KH +L+ +FW
Sbjct: 82 VFLQHGLLADSSNWVTNLANSSLGFILADAGFDVWMGNSRGNTWSRKHKTLSVSQDEFWA 141
Query: 367 FSWDEMASFDLPACVDYALKISGNATKLTYIGHSQGTEIAFAQFSQDVLLRKKISSYVAL 546
FS+DEMA +DLPA +++ L +G ++ Y+GHSQGT I F FSQ L K+I + AL
Sbjct: 142 FSYDEMAKYDLPASINFILNKTGQ-EQVYYVGHSQGTTIGFIAFSQIPELAKRIKMFFAL 200
Query: 547 APAVFLGNVEAGLRILARFREDIETLLNLFGHGRVMSNSEIFKFLASTICGKEGLPKFCS 726
P + + + L R + + + +LFG + S K+L + +C L + C
Sbjct: 201 GPVASVAFCTSPMAKLGRLPDHL--IKDLFGDKEFLPQSAFLKWLGTHVCTHVILKELCG 258
Query: 727 EVIFLLAGHDIKNLNESRLPVYISHTPA 810
+ FLL G + +NLN SR+ VY +H+PA
Sbjct: 259 NLCFLLCGFNERNLNMSRVDVYTTHSPA 286
>sp|Q29458|LIPG_BOVIN Gastric triacylglycerol lipase precursor (Gastric lipase) (GL)
(Pregastric esterase) (PGE)
Length = 397
Score = 220 bits (561), Expect = 3e-57
Identities = 116/264 (43%), Positives = 158/264 (59%)
Frame = +1
Query: 19 DPEVKMNISEIIRYNGYPCEDHRVVTKDGYILSMQRIPFGSKTRERQTKMTQSRPVVLLQ 198
+PE MN+S++I Y GYP E H+V+T DGYIL + RIP G + RPVV LQ
Sbjct: 27 NPEASMNVSQMISYWGYPSEMHKVITADGYILQVYRIPHGKNNANHLGQ----RPVVFLQ 82
Query: 199 HGLLDSAHTWAINSPEQSLAFILADHGFDVWLANSRGNTYSNKHVSLNERDPKFWEFSWD 378
HGLL SA W N P+ SL F+LAD G+DVWL NSRGNT++ +H+ + P+FW FS+D
Sbjct: 83 HGLLGSATNWISNLPKNSLGFLLADAGYDVWLGNSRGNTWAQEHLYYSPDSPEFWAFSFD 142
Query: 379 EMASFDLPACVDYALKISGNATKLTYIGHSQGTEIAFAQFSQDVLLRKKISSYVALAPAV 558
EMA +DLP+ +D+ L+ +G KL Y+GHSQGT I F FS L +KI + ALAP
Sbjct: 143 EMAEYDLPSTIDFILRRTGQ-KKLHYVGHSQGTTIGFIAFSTSPTLAEKIKVFYALAPVA 201
Query: 559 FLGNVEAGLRILARFREDIETLLNLFGHGRVMSNSEIFKFLASTICGKEGLPKFCSEVIF 738
+ ++ LA + + +FG ++ + +FL +C +E L C +F
Sbjct: 202 TVKYTKSLFNKLALIPHFLFKI--IFGDKMFYPHTFLEQFLGVEMCSRETLDVLCKNALF 259
Query: 739 LLAGHDIKNLNESRLPVYISHTPA 810
+ G D KN N SRL VYI+H PA
Sbjct: 260 AITGVDNKNFNMSRLDVYIAHNPA 283
>sp|Q64194|LICH_RAT Lysosomal acid lipase/cholesteryl ester hydrolase precursor (LAL)
(Acid cholesteryl ester hydrolase) (Sterol esterase)
(Lipase A) (Cholesteryl esterase)
Length = 397
Score = 207 bits (526), Expect = 4e-53
Identities = 116/270 (42%), Positives = 162/270 (60%), Gaps = 2/270 (0%)
Frame = +1
Query: 7 VTSVDPEVKMNISEIIRYNGYPCEDHRVVTKDGYILSMQRIPFGSKTRERQTKMTQSRPV 186
+++VDPE MN++EII + GYP +H V T DGYIL + RIP G K + + +PV
Sbjct: 24 ISAVDPEANMNVTEIIMHWGYP--EHSVQTGDGYILGVHRIPHGRKNQFDKGP----KPV 77
Query: 187 VLLQ--HGLLDSAHTWAINSPEQSLAFILADHGFDVWLANSRGNTYSNKHVSLNERDPKF 360
V LQ HG L + W N SL FILAD GFDVW+ NSRGNT+S KH +L+ ++
Sbjct: 78 VYLQWRHGFLADSSNWVTNIDNNSLGFILADAGFDVWMGNSRGNTWSRKHKTLSVSQDEY 137
Query: 361 WEFSWDEMASFDLPACVDYALKISGNATKLTYIGHSQGTEIAFAQFSQDVLLRKKISSYV 540
W FS+DEMA +DLPA ++Y L +G +L +GHSQG I F FSQ L KK+ +
Sbjct: 138 WAFSFDEMAKYDLPASINYILNKTGQ-EQLYNVGHSQGCTIGFIAFSQMPELAKKVKMFF 196
Query: 541 ALAPAVFLGNVEAGLRILARFREDIETLLNLFGHGRVMSNSEIFKFLASTICGKEGLPKF 720
ALAP + L + L R + + L +LFG + + S + K+L++ IC + +
Sbjct: 197 ALAPVLSLNFASGPMVKLGRLPDLL--LEDLFGQKQFLPQSAMVKWLSTHICTHVIMKEL 254
Query: 721 CSEVIFLLAGHDIKNLNESRLPVYISHTPA 810
C+ + FL+ G + KNLN SR+ VY +H PA
Sbjct: 255 CANIFFLICGFNEKNLNMSRVDVYTTHCPA 284
>sp|O46108|LIP3_DROME Lipase 3 precursor (DmLip3)
Length = 394
Score = 172 bits (436), Expect = 1e-42
Identities = 96/257 (37%), Positives = 141/257 (54%), Gaps = 2/257 (0%)
Frame = +1
Query: 46 EIIRYNGYPCEDHRVVTKDGYILSMQRIPFGSKTRERQTKMTQSRPVVLLQHGLLDSAHT 225
E I +GYP E H VVT D YIL+M RIP+ KT E + +RPV L HG+L S+
Sbjct: 30 ERIEDDGYPMERHEVVTSDNYILTMHRIPYSPKTGE-----SSNRPVAFLMHGMLSSSSD 84
Query: 226 WAINSPEQSLAFILADHGFDVWLANSRGNTYSNKHVSLNERDPKFWEFSWDEMASFDLPA 405
W + PE+SLA++LAD G+DVW+ N+RGNTYS H FW FSW+E+ +D+PA
Sbjct: 85 WVLMGPERSLAYMLADAGYDVWMGNARGNTYSKAHKYWPTYWQIFWNFSWNEIGMYDVPA 144
Query: 406 CVDYALKISGNATKLTYIGHSQGTEIAFAQFSQDVLLRKKISSYVALAPAVFLGNVEAGL 585
+DY L +G ++ Y+GHSQGT + S+ KI S L PA ++GN+++ L
Sbjct: 145 MIDYVLAKTGQ-QQVQYVGHSQGTTVYLVMVSERPEYNDKIKSAHLLGPAAYMGNMKSPL 203
Query: 586 -RILARFREDIETLLNLFGHGRVMSNSEIFKFLASTIC-GKEGLPKFCSEVIFLLAGHDI 759
R A ++ + G M +++ + L +C C+ IFL+ G+D
Sbjct: 204 TRAFAPILGQPNAIVEVCGSMEFMPSNKFKQDLGIEMCQATSPYADMCANEIFLIGGYDT 263
Query: 760 KNLNESRLPVYISHTPA 810
+ L+ L + +PA
Sbjct: 264 EQLDYELLEHIKATSPA 280
>sp|O46107|LIP1_DROME Lipase 1 precursor (DmLip1)
Length = 439
Score = 168 bits (426), Expect = 1e-41
Identities = 103/268 (38%), Positives = 139/268 (51%), Gaps = 2/268 (0%)
Frame = +1
Query: 13 SVDPEVKMNISEIIRYNGYPCEDHRVVTKDGYILSMQRIPFGSKTRERQTKMTQSRPVVL 192
++ + +++ ++I GY E H V T+DGYIL+M RI Q P L
Sbjct: 59 NIKQDSTLSVDKLIAKYGYESEVHHVTTEDGYILTMHRI------------RKQGAPPFL 106
Query: 193 LQHGLLDSAHTWAINSPEQSLAFILADHGFDVWLANSRGNTYSNKHVSLNERDPKFWEFS 372
LQHGL+DS+ + + P SLA++LADH +DVWL N+RGN YS H +L+ + KFW+FS
Sbjct: 107 LQHGLVDSSAGFVVMGPNVSLAYLLADHNYDVWLGNARGNRYSRNHTTLDPDESKFWDFS 166
Query: 373 WDEMASFDLPACVDYALKISGNATKLTYIGHSQGTEIAFAQFSQDVLLRKKISSYVALAP 552
W E+ +DLPA +D+ LK++G KL Y GHSQG F S K+ S ALAP
Sbjct: 167 WHEIGMYDLPAMIDHVLKVTG-FPKLHYAGHSQGCTSFFVMCSMRPAYNDKVVSMQALAP 225
Query: 553 AVFLGNVEAGLRILARFREDIETLLN-LFGHG-RVMSNSEIFKFLASTICGKEGLPKFCS 726
AV+ E I A I N L G R M N E F+FL E + C
Sbjct: 226 AVYAKETEDHPYIRA-----ISLYFNSLVGSSIREMFNGE-FRFLCRM---TEETERLCI 276
Query: 727 EVIFLLAGHDIKNLNESRLPVYISHTPA 810
E +F + G + N PV + H PA
Sbjct: 277 EAVFGIVGRNWNEFNRKMFPVILGHYPA 304
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 106,021,971
Number of Sequences: 369166
Number of extensions: 2305115
Number of successful extensions: 5822
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 5536
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 5786
length of database: 68,354,980
effective HSP length: 109
effective length of database: 48,218,865
effective search space used: 7715018400
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)