Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_026_K16
(634 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q63081|PDIA6_RAT Protein disulfide-isomerase A6 precurso... 153 3e-37
sp|Q15084|PDIA6_HUMAN Protein disulfide-isomerase A6 precur... 152 7e-37
sp|Q5R6T1|PDIA6_PONPY Protein disulfide-isomerase A6 precursor 152 7e-37
sp|P38660|PDIA6_MESAU Protein disulfide-isomerase A6 precur... 150 2e-36
sp|Q922R8|PDIA6_MOUSE Protein disulfide-isomerase A6 precur... 150 3e-36
sp|Q11067|PDIA6_CAEEL Probable protein disulfide-isomerase ... 143 4e-34
sp|Q17770|PDI2_CAEEL Protein disulfide-isomerase 2 precurso... 92 8e-19
sp|P34329|PDIA4_CAEEL Probable protein disulfide-isomerase ... 90 4e-18
sp|Q92249|ERP38_NEUCR Protein disulfide-isomerase erp38 pre... 86 6e-17
sp|P38661|PDIA6_MEDSA Probable protein disulfide-isomerase ... 86 8e-17
>sp|Q63081|PDIA6_RAT Protein disulfide-isomerase A6 precursor (Protein disulfide
isomerase P5) (Calcium-binding protein 1) (CaBP1)
(Thioredoxin domain-containing protein 7)
Length = 440
Score = 153 bits (387), Expect = 3e-37
Identities = 71/97 (73%), Positives = 80/97 (82%), Gaps = 1/97 (1%)
Frame = +3
Query: 45 ALYSPSDDVIDLTPSNFN-DVKNGDELWFVEFYAPWCGHCQSLAPEWKKAASALKGVVKV 221
ALYS SDDVI+LTPSNFN +V D LW VEFYAPWCGHCQ L PEWKKAASALK VVKV
Sbjct: 19 ALYSSSDDVIELTPSNFNREVIQSDSLWLVEFYAPWCGHCQRLTPEWKKAASALKDVVKV 78
Query: 222 GAVDMDKYSSVGQPYNIQGFPTIKVFGKNKHSPKDYQ 332
GAV+ DK+ S+G Y +QGFPTIK+FG NK+ P+DYQ
Sbjct: 79 GAVNADKHQSLGGQYGVQGFPTIKIFGANKNKPEDYQ 115
Score = 92.4 bits (228), Expect = 8e-19
Identities = 46/97 (47%), Positives = 63/97 (64%), Gaps = 5/97 (5%)
Frame = +3
Query: 54 SPSDDVIDLTPSNFN-DVKNGDELWFVEFYAPWCGHCQSLAPEWKKAASAL----KGVVK 218
S DV++LT F+ +V + +++W VEFYAPWCGHC++L PEW AA+ + KG VK
Sbjct: 157 SSKKDVVELTDDTFDKNVLDSEDVWMVEFYAPWCGHCKNLEPEWAAAATEVKEQTKGKVK 216
Query: 219 VGAVDMDKYSSVGQPYNIQGFPTIKVFGKNKHSPKDY 329
+ AVD + Y I+GFPTIK+F K + SP DY
Sbjct: 217 LAAVDATVNQVLASRYGIKGFPTIKIFQKGE-SPVDY 252
>sp|Q15084|PDIA6_HUMAN Protein disulfide-isomerase A6 precursor (Protein disulfide
isomerase P5) (Thioredoxin domain-containing protein 7)
Length = 440
Score = 152 bits (384), Expect = 7e-37
Identities = 70/96 (72%), Positives = 79/96 (82%), Gaps = 1/96 (1%)
Frame = +3
Query: 48 LYSPSDDVIDLTPSNFN-DVKNGDELWFVEFYAPWCGHCQSLAPEWKKAASALKGVVKVG 224
LYS SDDVI+LTPSNFN +V D LW VEFYAPWCGHCQ L PEWKKAA+ALK VVKVG
Sbjct: 20 LYSSSDDVIELTPSNFNREVIQSDSLWLVEFYAPWCGHCQRLTPEWKKAATALKDVVKVG 79
Query: 225 AVDMDKYSSVGQPYNIQGFPTIKVFGKNKHSPKDYQ 332
AVD DK+ S+G Y +QGFPTIK+FG NK+ P+DYQ
Sbjct: 80 AVDADKHHSLGGQYGVQGFPTIKIFGSNKNRPEDYQ 115
Score = 94.4 bits (233), Expect = 2e-19
Identities = 48/97 (49%), Positives = 64/97 (65%), Gaps = 5/97 (5%)
Frame = +3
Query: 54 SPSDDVIDLTPSNFN-DVKNGDELWFVEFYAPWCGHCQSLAPEWKKAASAL----KGVVK 218
S DVI+LT +F+ +V + +++W VEFYAPWCGHC++L PEW AAS + KG VK
Sbjct: 157 SSKKDVIELTDDSFDKNVLDSEDVWMVEFYAPWCGHCKNLEPEWAAAASEVKEQTKGKVK 216
Query: 219 VGAVDMDKYSSVGQPYNIQGFPTIKVFGKNKHSPKDY 329
+ AVD + Y I+GFPTIK+F K + SP DY
Sbjct: 217 LAAVDATVNQVLASRYGIRGFPTIKIFQKGE-SPVDY 252
>sp|Q5R6T1|PDIA6_PONPY Protein disulfide-isomerase A6 precursor
Length = 440
Score = 152 bits (384), Expect = 7e-37
Identities = 70/96 (72%), Positives = 79/96 (82%), Gaps = 1/96 (1%)
Frame = +3
Query: 48 LYSPSDDVIDLTPSNFN-DVKNGDELWFVEFYAPWCGHCQSLAPEWKKAASALKGVVKVG 224
LYS SDDVI+LTPSNFN +V D LW VEFYAPWCGHCQ L PEWKKAA+ALK VVKVG
Sbjct: 20 LYSSSDDVIELTPSNFNREVIQSDSLWLVEFYAPWCGHCQRLTPEWKKAATALKDVVKVG 79
Query: 225 AVDMDKYSSVGQPYNIQGFPTIKVFGKNKHSPKDYQ 332
AVD DK+ S+G Y +QGFPTIK+FG NK+ P+DYQ
Sbjct: 80 AVDADKHHSLGGQYGVQGFPTIKIFGSNKNRPEDYQ 115
Score = 94.4 bits (233), Expect = 2e-19
Identities = 48/97 (49%), Positives = 64/97 (65%), Gaps = 5/97 (5%)
Frame = +3
Query: 54 SPSDDVIDLTPSNFN-DVKNGDELWFVEFYAPWCGHCQSLAPEWKKAASAL----KGVVK 218
S DVI+LT +F+ +V + +++W VEFYAPWCGHC++L PEW AAS + KG VK
Sbjct: 157 SSKKDVIELTDDSFDKNVLDSEDVWMVEFYAPWCGHCKNLEPEWAAAASEVKEQTKGKVK 216
Query: 219 VGAVDMDKYSSVGQPYNIQGFPTIKVFGKNKHSPKDY 329
+ AVD + Y I+GFPTIK+F K + SP DY
Sbjct: 217 LAAVDATVNQVLASRYGIRGFPTIKIFQKGE-SPVDY 252
>sp|P38660|PDIA6_MESAU Protein disulfide-isomerase A6 precursor (Protein disulfide
isomerase P5)
Length = 439
Score = 150 bits (380), Expect = 2e-36
Identities = 69/96 (71%), Positives = 79/96 (82%), Gaps = 1/96 (1%)
Frame = +3
Query: 48 LYSPSDDVIDLTPSNFN-DVKNGDELWFVEFYAPWCGHCQSLAPEWKKAASALKGVVKVG 224
LYS SDDVI+LTPSNFN +V + LW VEFYAPWCGHCQ L PEWKKAA+ALK VVKVG
Sbjct: 20 LYSSSDDVIELTPSNFNREVIQSNSLWLVEFYAPWCGHCQRLTPEWKKAATALKDVVKVG 79
Query: 225 AVDMDKYSSVGQPYNIQGFPTIKVFGKNKHSPKDYQ 332
AVD DK+ S+G Y +QGFPTIK+FG NK+ P+DYQ
Sbjct: 80 AVDADKHQSLGGQYGVQGFPTIKIFGANKNKPEDYQ 115
Score = 93.2 bits (230), Expect = 5e-19
Identities = 47/97 (48%), Positives = 63/97 (64%), Gaps = 5/97 (5%)
Frame = +3
Query: 54 SPSDDVIDLTPSNFN-DVKNGDELWFVEFYAPWCGHCQSLAPEWKKAASAL----KGVVK 218
S DVI+LT F+ +V + D++W VEFYAPWCGHC++L PEW AA+ + KG VK
Sbjct: 157 SSKKDVIELTDDTFDKNVLDSDDVWMVEFYAPWCGHCKNLEPEWATAATEVKEQTKGKVK 216
Query: 219 VGAVDMDKYSSVGQPYNIQGFPTIKVFGKNKHSPKDY 329
+ AVD + Y I+GFPTIK+F K + +P DY
Sbjct: 217 LAAVDATVNQVLANRYGIRGFPTIKIFQKGE-APVDY 252
>sp|Q922R8|PDIA6_MOUSE Protein disulfide-isomerase A6 precursor (Thioredoxin
domain-containing protein 7)
Length = 440
Score = 150 bits (378), Expect = 3e-36
Identities = 69/96 (71%), Positives = 79/96 (82%), Gaps = 1/96 (1%)
Frame = +3
Query: 48 LYSPSDDVIDLTPSNFN-DVKNGDELWFVEFYAPWCGHCQSLAPEWKKAASALKGVVKVG 224
LYS SDDVI+LTPSNFN +V D LW VEFYAPWCGHCQ L PEWKKAA+ALK VVKVG
Sbjct: 20 LYSSSDDVIELTPSNFNREVIQSDGLWLVEFYAPWCGHCQRLTPEWKKAATALKDVVKVG 79
Query: 225 AVDMDKYSSVGQPYNIQGFPTIKVFGKNKHSPKDYQ 332
AV+ DK+ S+G Y +QGFPTIK+FG NK+ P+DYQ
Sbjct: 80 AVNADKHQSLGGQYGVQGFPTIKIFGANKNKPEDYQ 115
Score = 92.4 bits (228), Expect = 8e-19
Identities = 46/97 (47%), Positives = 63/97 (64%), Gaps = 5/97 (5%)
Frame = +3
Query: 54 SPSDDVIDLTPSNFN-DVKNGDELWFVEFYAPWCGHCQSLAPEWKKAASAL----KGVVK 218
S DV++LT F+ +V + +++W VEFYAPWCGHC++L PEW AA+ + KG VK
Sbjct: 157 SSKKDVVELTDDTFDKNVLDSEDVWMVEFYAPWCGHCKNLEPEWAAAATEVKEQTKGKVK 216
Query: 219 VGAVDMDKYSSVGQPYNIQGFPTIKVFGKNKHSPKDY 329
+ AVD + Y I+GFPTIK+F K + SP DY
Sbjct: 217 LAAVDATVNQVLASRYGIKGFPTIKIFQKGE-SPVDY 252
>sp|Q11067|PDIA6_CAEEL Probable protein disulfide-isomerase A6 precursor
Length = 440
Score = 143 bits (360), Expect = 4e-34
Identities = 66/104 (63%), Positives = 81/104 (77%), Gaps = 3/104 (2%)
Frame = +3
Query: 48 LYSPSDDVIDLTPSNFND-VKNGDELWFVEFYAPWCGHCQSLAPEWKKAASALKGVVKVG 224
+YS DDV++LT +NF V N D++W VEFYAPWCGHC+SL PE+KKAASALKGV KVG
Sbjct: 19 MYSKKDDVVELTEANFQSKVINSDDIWIVEFYAPWCGHCKSLVPEYKKAASALKGVAKVG 78
Query: 225 AVDMDKYSSVGQPYNIQGFPTIKVFGKNKHSPKDY--QEPAQIL 350
AVDM ++ SVG PYN+QGFPT+K+FG +K P DY Q AQ +
Sbjct: 79 AVDMTQHQSVGGPYNVQGFPTLKIFGADKKKPTDYNGQRTAQAI 122
Score = 100 bits (249), Expect = 3e-21
Identities = 46/92 (50%), Positives = 65/92 (70%), Gaps = 3/92 (3%)
Frame = +3
Query: 63 DDVIDLTPSNFND-VKNGDELWFVEFYAPWCGHCQSLAPEWKKAASALKGVVKVGAVDMD 239
++V++LT +NF D V N ++W VEF+APWCGHC+SL P+WK AAS LKG V++GA+D
Sbjct: 164 NEVVELTDANFEDLVLNSKDIWLVEFFAPWCGHCKSLEPQWKAAASELKGKVRLGALDAT 223
Query: 240 KYSSVGQPYNIQGFPTIKVF--GKNKHSPKDY 329
++ V + I+GFPTIK F G + +DY
Sbjct: 224 VHTVVANKFAIRGFPTIKYFAPGSDVSDAQDY 255
>sp|Q17770|PDI2_CAEEL Protein disulfide-isomerase 2 precursor (PDI 1) (Prolyl
4-hydroxylase beta subunit)
Length = 493
Score = 92.4 bits (228), Expect = 8e-19
Identities = 44/98 (44%), Positives = 65/98 (66%), Gaps = 3/98 (3%)
Frame = +3
Query: 45 ALYSPSDDVIDLTPSNFNDVKNGDELWFVEFYAPWCGHCQSLAPEWKKAASALK---GVV 215
A+ ++VI LT NF++V NG+E VEFYAPWCGHC+SLAPE+ KAA+ LK +
Sbjct: 17 AVIEEEENVIVLTKDNFDEVINGNEFILVEFYAPWCGHCKSLAPEYAKAATQLKEEGSDI 76
Query: 216 KVGAVDMDKYSSVGQPYNIQGFPTIKVFGKNKHSPKDY 329
K+G +D + V + ++G+PT+K+F K P++Y
Sbjct: 77 KLGKLDATVHGEVSSKFEVRGYPTLKLFRNGK--PQEY 112
Score = 62.0 bits (149), Expect = 1e-09
Identities = 32/85 (37%), Positives = 40/85 (47%), Gaps = 1/85 (1%)
Frame = +3
Query: 78 LTPSNFNDV-KNGDELWFVEFYAPWCGHCQSLAPEWKKAASALKGVVKVGAVDMDKYSSV 254
L NF V ++ + VEFYAPWCGHC+ LAP W K + MD +
Sbjct: 368 LVGKNFEQVARDNTKNVLVEFYAPWCGHCKQLAPTWDKLGEKFADDESIVIAKMDSTLNE 427
Query: 255 GQPYNIQGFPTIKVFGKNKHSPKDY 329
+ IQ FPTIK F + DY
Sbjct: 428 VEDVKIQSFPTIKFFPAGSNKVVDY 452
>sp|P34329|PDIA4_CAEEL Probable protein disulfide-isomerase A4 precursor (ERp-72 homolog)
Length = 618
Score = 90.1 bits (222), Expect = 4e-18
Identities = 47/110 (42%), Positives = 67/110 (60%), Gaps = 6/110 (5%)
Frame = +3
Query: 57 PSDDVIDLTPSNFNDVKNGDELWFVEFYAPWCGHCQSLAPEWKKAASALK---GVVKVGA 227
P ++V+ LT NF+D + +EL VEFYAPWCGHC+ LAPE++KAA LK VK+G
Sbjct: 145 PPEEVVTLTTENFDDFISNNELVLVEFYAPWCGHCKKLAPEYEKAAQKLKAQGSKVKLGK 204
Query: 228 VDMDKYSSVGQPYNIQGFPTIKVFGKNKHSPKDY---QEPAQILKQIFDK 368
VD +G Y + G+PT+K+ + DY +E A I+K + D+
Sbjct: 205 VDATIEKDLGTKYGVSGYPTMKIIRNGRRF--DYNGpreAAGIIKYMTDQ 252
Score = 75.5 bits (184), Expect = 1e-13
Identities = 39/96 (40%), Positives = 57/96 (59%)
Frame = +3
Query: 42 EALYSPSDDVIDLTPSNFNDVKNGDELWFVEFYAPWCGHCQSLAPEWKKAASALKGVVKV 221
E Y + V+ LT NF+ + V+FYAPWCGHC+ LAPE++KA+S K + +
Sbjct: 29 ELNYEMDEGVVVLTDKNFDAFLKKNPSVLVKFYAPWCGHCKHLAPEYEKASS--KVSIPL 86
Query: 222 GAVDMDKYSSVGQPYNIQGFPTIKVFGKNKHSPKDY 329
VD + +G+ + IQG+PT+K F K+ P DY
Sbjct: 87 AKVDATVETELGKRFEIQGYPTLK-FWKDGKGPNDY 121
Score = 50.8 bits (120), Expect = 3e-06
Identities = 31/85 (36%), Positives = 45/85 (52%), Gaps = 6/85 (7%)
Frame = +3
Query: 54 SPSDD---VIDLTPSNFNDVKNGDEL-WFVEFYAPWCGHCQSLAPEWKKAASALKGV-VK 218
+P DD V + SNF+ + N + +EFYAPWCGHC+S ++ + A ALK
Sbjct: 493 APKDDKGPVKTVVGSNFDKIVNDESKDVLIEFYAPWCGHCKSFESKYVELAQALKKTQPN 552
Query: 219 VGAVDMD-KYSSVGQPYNIQGFPTI 290
V MD + + ++GFPTI
Sbjct: 553 VVLAKMDATINDAPSQFAVEGFPTI 577
>sp|Q92249|ERP38_NEUCR Protein disulfide-isomerase erp38 precursor (ERp38)
Length = 369
Score = 86.3 bits (212), Expect = 6e-17
Identities = 43/93 (46%), Positives = 62/93 (66%), Gaps = 5/93 (5%)
Frame = +3
Query: 69 VIDLTPSNFNDV--KNGDELWFVEFYAPWCGHCQSLAPEWKKAASAL---KGVVKVGAVD 233
V+DL PSNF+DV K+G VEF+APWCGHC++LAP +++ A+AL K V++ VD
Sbjct: 22 VLDLIPSNFDDVVLKSGKPT-LVEFFAPWCGHCKNLAPVYEELATALEYAKDKVQIAKVD 80
Query: 234 MDKYSSVGQPYNIQGFPTIKVFGKNKHSPKDYQ 332
D ++G+ + +QGFPT+K F P DY+
Sbjct: 81 ADAERALGKRFGVQGFPTLKFFDGKSEQPVDYK 113
Score = 68.2 bits (165), Expect = 2e-11
Identities = 34/93 (36%), Positives = 52/93 (55%), Gaps = 7/93 (7%)
Frame = +3
Query: 111 GDELWFVEFYAPWCGHCQSLAPEWKKAASALKGVVKVGAVDMDKYSSVGQ----PYNIQG 278
GD+ V F APWCGHC++LAP W+K A+ ++ +D + G+ Y + G
Sbjct: 157 GDKNVLVAFTAPWCGHCKNLAPTWEKLAATFASDPEITIAKVDADAPTGKKSAAEYGVSG 216
Query: 279 FPTIKVFGKNKHSPKDY---QEPAQILKQIFDK 368
FPTIK F K +P+DY + A ++K + +K
Sbjct: 217 FPTIKFFPKGSTTPEDYNGGRSEADLVKFLNEK 249
>sp|P38661|PDIA6_MEDSA Probable protein disulfide-isomerase A6 precursor (P5)
Length = 364
Score = 85.9 bits (211), Expect = 8e-17
Identities = 41/95 (43%), Positives = 57/95 (60%), Gaps = 2/95 (2%)
Frame = +3
Query: 60 SDDVIDLTPSNFNDVKNGDELWFVEFYAPWCGHCQSLAPEWKKAASALKGV--VKVGAVD 233
+DDV+ LT NF D+ VEFYAPWCGHC+ LAPE++K ++ K V + VD
Sbjct: 28 ADDVVVLTEENFEKEVGHDKGALVEFYAPWCGHCKKLAPEYEKLPNSFKKAKSVLIAKVD 87
Query: 234 MDKYSSVGQPYNIQGFPTIKVFGKNKHSPKDYQEP 338
D++ SV Y + G+PTI+ F K PK ++ P
Sbjct: 88 CDEHKSVCSKYGVSGYPTIQWFPKGSLEPKKFEGP 122
Score = 85.5 bits (210), Expect = 1e-16
Identities = 41/90 (45%), Positives = 58/90 (64%), Gaps = 3/90 (3%)
Frame = +3
Query: 69 VIDLTPSNFNDVK-NGDELWFVEFYAPWCGHCQSLAPEWKKAASALKGV--VKVGAVDMD 239
V+ LTP FN+V +G + VEFYAPWCGHC+SLAP ++K A+ K V + +D D
Sbjct: 149 VVVLTPETFNEVVLDGTKDVLVEFYAPWCGHCKSLAPIYEKVAAVFKSEDDVVIANLDAD 208
Query: 240 KYSSVGQPYNIQGFPTIKVFGKNKHSPKDY 329
KY + + Y++ GFPT+K F K + +DY
Sbjct: 209 KYRDLAEKYDVSGFPTLKFFPKGNKAGEDY 238
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 62,081,146
Number of Sequences: 369166
Number of extensions: 1135887
Number of successful extensions: 3204
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 2995
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 3103
length of database: 68,354,980
effective HSP length: 106
effective length of database: 48,773,070
effective search space used: 5072399280
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)