Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_026_I11
(721 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q9WTX6|CUL1_MOUSE Cullin-1 (CUL-1) 129 8e-30
sp|Q13616|CUL1_HUMAN Cullin-1 (CUL-1) >gi|67460204|sp|Q5R4G... 129 8e-30
sp|Q24311|CUL1_DROME Cullin homolog 1 (Lin-19 homolog protein) 120 3e-27
sp|Q17389|CUL1_CAEEL Cullin-1 (Abnormal cell lineage 19 pro... 114 3e-25
sp|Q13617|CUL2_HUMAN Cullin-2 (CUL-2) >gi|67460208|sp|Q5RCF... 102 8e-22
sp|Q9D4H8|CUL2_MOUSE Cullin-2 (CUL-2) 102 1e-21
sp|O13790|CUL1_SCHPO Cullin-1 homolog (Cul-1) (Cell divisio... 101 2e-21
sp|Q21346|CUL6_CAEEL Cullin-6 100 7e-21
sp|Q09760|CUL3_SCHPO Cullin-3 homolog (Cul-3) 84 4e-16
sp|Q94AH6|CUL1_ARATH Cullin-1 84 5e-16
>sp|Q9WTX6|CUL1_MOUSE Cullin-1 (CUL-1)
Length = 776
Score = 129 bits (324), Expect = 8e-30
Identities = 67/128 (52%), Positives = 90/128 (70%), Gaps = 1/128 (0%)
Frame = +1
Query: 4 DTNVNLENDEI-PDISTITVVHLYTDYKNKRIRVNLNLQLKGETKQEVEEVISRVDHDRR 180
D N N++ E+ PD T++ LY YKNK++RVN+N+ +K E KQE E ++ DR+
Sbjct: 653 DENANVDEVELKPD----TLIKLYLGYKNKKLRVNINVPMKTEQKQEQETTHKNIEEDRK 708
Query: 181 MAIDACIVRVMKTRKTLKHQELVREVLEQLSTKFNPQVSLIKRCIAGLIEKEYLKRDSNC 360
+ I A IVR+MK RK LKHQ+L+ EVL QLS++F P+V +IK+CI LIEKEYL+R
Sbjct: 709 LLIQAAIVRIMKMRKVLKHQQLLGEVLTQLSSRFKPRVPVIKKCIDILIEKEYLERVDGE 768
Query: 361 KDTYQYLA 384
KDTY YLA
Sbjct: 769 KDTYSYLA 776
>sp|Q13616|CUL1_HUMAN Cullin-1 (CUL-1)
sp|Q5R4G6|CUL1_PONPY Cullin-1 (CUL-1)
Length = 776
Score = 129 bits (324), Expect = 8e-30
Identities = 67/128 (52%), Positives = 90/128 (70%), Gaps = 1/128 (0%)
Frame = +1
Query: 4 DTNVNLENDEI-PDISTITVVHLYTDYKNKRIRVNLNLQLKGETKQEVEEVISRVDHDRR 180
D N N++ E+ PD T++ LY YKNK++RVN+N+ +K E KQE E ++ DR+
Sbjct: 653 DENANVDEVELKPD----TLIKLYLGYKNKKLRVNINVPMKTEQKQEQETTHKNIEEDRK 708
Query: 181 MAIDACIVRVMKTRKTLKHQELVREVLEQLSTKFNPQVSLIKRCIAGLIEKEYLKRDSNC 360
+ I A IVR+MK RK LKHQ+L+ EVL QLS++F P+V +IK+CI LIEKEYL+R
Sbjct: 709 LLIQAAIVRIMKMRKVLKHQQLLGEVLTQLSSRFKPRVPVIKKCIDILIEKEYLERVDGE 768
Query: 361 KDTYQYLA 384
KDTY YLA
Sbjct: 769 KDTYSYLA 776
>sp|Q24311|CUL1_DROME Cullin homolog 1 (Lin-19 homolog protein)
Length = 774
Score = 120 bits (302), Expect = 3e-27
Identities = 64/126 (50%), Positives = 83/126 (65%)
Frame = +1
Query: 7 TNVNLENDEIPDISTITVVHLYTDYKNKRIRVNLNLQLKGETKQEVEEVISRVDHDRRMA 186
T+ + EN P+ + V L+ DYKNK+ R+N+N LK E K E E V ++ DR++
Sbjct: 653 TSSDNENSLTPE----STVELFLDYKNKKRRININQPLKTELKVEQETVHKHIEEDRKLL 708
Query: 187 IDACIVRVMKTRKTLKHQELVREVLEQLSTKFNPQVSLIKRCIAGLIEKEYLKRDSNCKD 366
I A IVR+MK RK L H L+ EVL QLST+F P+V +IK+CI LIEKEYL+R KD
Sbjct: 709 IQAAIVRIMKMRKRLNHTNLISEVLNQLSTRFKPKVPVIKKCIDILIEKEYLERMEGHKD 768
Query: 367 TYQYLA 384
TY YLA
Sbjct: 769 TYSYLA 774
>sp|Q17389|CUL1_CAEEL Cullin-1 (Abnormal cell lineage 19 protein)
Length = 780
Score = 114 bits (284), Expect = 3e-25
Identities = 60/128 (46%), Positives = 86/128 (67%), Gaps = 1/128 (0%)
Frame = +1
Query: 4 DTNVNLENDEIPDISTITVVHLYTDYKNKRIRVNLN-LQLKGETKQEVEEVISRVDHDRR 180
DT + E DE+P +T++ L Y NK++RV+L+ +K + ++ E V V+ DR+
Sbjct: 657 DTELQKE-DEVPMTATVS---LNKAYMNKKVRVDLSKFTMKQDAVRDTENVQKNVEEDRK 712
Query: 181 MAIDACIVRVMKTRKTLKHQELVREVLEQLSTKFNPQVSLIKRCIAGLIEKEYLKRDSNC 360
I ACIVR+MKTRK ++HQ+L+ EV+ QLS +F P+V +IKRCI LIEKEY+ R
Sbjct: 713 SVISACIVRIMKTRKRVQHQQLMTEVITQLSGRFKPKVEMIKRCIGSLIEKEYMLRTEGQ 772
Query: 361 KDTYQYLA 384
KD Y+YLA
Sbjct: 773 KDLYEYLA 780
>sp|Q13617|CUL2_HUMAN Cullin-2 (CUL-2)
sp|Q5RCF3|CUL2_PONPY Cullin-2 (CUL-2)
Length = 745
Score = 102 bits (255), Expect = 8e-22
Identities = 48/128 (37%), Positives = 78/128 (60%)
Frame = +1
Query: 1 IDTNVNLENDEIPDISTITVVHLYTDYKNKRIRVNLNLQLKGETKQEVEEVISRVDHDRR 180
+D + + E DI + L ++ +KR + + ++ +T QE+E+ S VD DR+
Sbjct: 618 LDVKMINHDSEKEDIDAESSFSLNMNFSSKRTKFKITTSMQKDTPQEMEQTRSAVDEDRK 677
Query: 181 MAIDACIVRVMKTRKTLKHQELVREVLEQLSTKFNPQVSLIKRCIAGLIEKEYLKRDSNC 360
M + A IVR+MK RK L+H L++EV+ Q +FNP +S+IK+CI LI+K+Y++R
Sbjct: 678 MYLQAAIVRIMKARKVLRHNALIQEVISQSRARFNPSISMIKKCIEVLIDKQYIERSQAS 737
Query: 361 KDTYQYLA 384
D Y Y+A
Sbjct: 738 ADEYSYVA 745
>sp|Q9D4H8|CUL2_MOUSE Cullin-2 (CUL-2)
Length = 745
Score = 102 bits (254), Expect = 1e-21
Identities = 48/128 (37%), Positives = 77/128 (60%)
Frame = +1
Query: 1 IDTNVNLENDEIPDISTITVVHLYTDYKNKRIRVNLNLQLKGETKQEVEEVISRVDHDRR 180
+D + + E DI + L + +KR + + ++ +T QE+E+ S VD DR+
Sbjct: 618 LDVKMINHDSEKEDIDAESSFSLNMSFSSKRTKFKITTSMQKDTPQELEQTRSAVDEDRK 677
Query: 181 MAIDACIVRVMKTRKTLKHQELVREVLEQLSTKFNPQVSLIKRCIAGLIEKEYLKRDSNC 360
M + A IVR+MK RK L+H L++EV+ Q +FNP +S+IK+CI LI+K+Y++R
Sbjct: 678 MYLQAAIVRIMKARKVLRHNALIQEVISQSRARFNPSISMIKKCIEVLIDKQYIERSQAS 737
Query: 361 KDTYQYLA 384
D Y Y+A
Sbjct: 738 ADEYSYVA 745
>sp|O13790|CUL1_SCHPO Cullin-1 homolog (Cul-1) (Cell division control 53 homolog)
Length = 767
Score = 101 bits (252), Expect = 2e-21
Identities = 52/121 (42%), Positives = 83/121 (68%)
Frame = +1
Query: 22 ENDEIPDISTITVVHLYTDYKNKRIRVNLNLQLKGETKQEVEEVISRVDHDRRMAIDACI 201
+ND++ D ++ ++ +++ K+IRV LNL ++ E KQE E ++ DR++ + + I
Sbjct: 651 DNDKLGDPNSTYKIN--ENFRMKKIRVQLNLPIRSEQKQESLETHKTIEEDRKLLLQSAI 708
Query: 202 VRVMKTRKTLKHQELVREVLEQLSTKFNPQVSLIKRCIAGLIEKEYLKRDSNCKDTYQYL 381
VR+MK R+TLKH LV+E ++Q+ ++F P+VS IK+CI LIEKEYL+R +D Y YL
Sbjct: 709 VRIMKARRTLKHVVLVKETIDQIKSRFTPKVSDIKQCIDMLIEKEYLERQG--RDEYIYL 766
Query: 382 A 384
A
Sbjct: 767 A 767
>sp|Q21346|CUL6_CAEEL Cullin-6
Length = 729
Score = 99.8 bits (247), Expect = 7e-21
Identities = 51/110 (46%), Positives = 73/110 (66%), Gaps = 1/110 (0%)
Frame = +1
Query: 58 VVHLYTDYKNKRIRVNLNLQLKGETK-QEVEEVISRVDHDRRMAIDACIVRVMKTRKTLK 234
VV L T Y NK++RV+L +K T +E + V + V+ DR+ I ACIVR+MKTRK+L
Sbjct: 620 VVSLNTKYANKKVRVDLTTAIKKATADRETDAVQNTVESDRKYEIKACIVRIMKTRKSLT 679
Query: 235 HQELVREVLEQLSTKFNPQVSLIKRCIAGLIEKEYLKRDSNCKDTYQYLA 384
H L+ E++ QL ++F P V +IK CI LIE+ Y++R N + Y+YLA
Sbjct: 680 HTLLINEIISQLKSRFTPNVQMIKICIEILIEQLYIRRSENEHNVYEYLA 729
>sp|Q09760|CUL3_SCHPO Cullin-3 homolog (Cul-3)
Length = 785
Score = 84.0 bits (206), Expect = 4e-16
Identities = 42/98 (42%), Positives = 62/98 (63%)
Frame = +1
Query: 91 RIRVNLNLQLKGETKQEVEEVISRVDHDRRMAIDACIVRVMKTRKTLKHQELVREVLEQL 270
RI+++ Q + E E + + +VD R+ DACIVRVMK RK +H +L+ EV QL
Sbjct: 688 RIKISTVAQTRVEDDSERKRTLEKVDESRKHQADACIVRVMKDRKVCEHNQLMAEVTRQL 747
Query: 271 STKFNPQVSLIKRCIAGLIEKEYLKRDSNCKDTYQYLA 384
+ +F+P +IKR I LIE+EYL+R ++ Y+YLA
Sbjct: 748 NPRFHPSPMMIKRRIEALIEREYLQRQADNGRIYEYLA 785
>sp|Q94AH6|CUL1_ARATH Cullin-1
Length = 738
Score = 83.6 bits (205), Expect = 5e-16
Identities = 45/102 (44%), Positives = 65/102 (63%)
Frame = +1
Query: 79 YKNKRIRVNLNLQLKGETKQEVEEVISRVDHDRRMAIDACIVRVMKTRKTLKHQELVREV 258
+ ++ R+ + L E K+ VE+V D DRR AIDA IVR+MK+RK L HQ+LV E
Sbjct: 641 FTDRMRRIKIPLPPVDERKKVVEDV----DKDRRYAIDAAIVRIMKSRKVLGHQQLVSEC 696
Query: 259 LEQLSTKFNPQVSLIKRCIAGLIEKEYLKRDSNCKDTYQYLA 384
+EQLS F P + IK+ + LI ++YL+RD + ++YLA
Sbjct: 697 VEQLSRMFKPDIKAIKKRMEDLITRDYLERDKENPNMFRYLA 738
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 67,436,415
Number of Sequences: 369166
Number of extensions: 1162541
Number of successful extensions: 2859
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 2793
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 2853
length of database: 68,354,980
effective HSP length: 107
effective length of database: 48,588,335
effective search space used: 6413660220
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)