Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_026_F20
(558 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q16611|BAK_HUMAN Bcl-2 homologous antagonist/killer (Apo... 68 2e-11
sp|Q13014|BAK2_HUMAN Putative Bcl-2 homologous antagonist/k... 67 3e-11
sp|O08734|BAK_MOUSE Bcl-2 homologous antagonist/killer (Apo... 66 7e-11
sp|Q91827|AR1_XENLA Apoptosis regulator R1 (XR1) 61 2e-09
sp|Q91828|AR11_XENLA Apoptosis regulator R11 (XR11) 50 4e-06
sp|Q92843|BCLW_HUMAN Apoptosis regulator Bcl-W (Bcl-2-like ... 47 3e-05
sp|P70345|BCLW_MOUSE Apoptosis regulator Bcl-W (Bcl-2-like ... 46 5e-05
sp|P53563|BCLX_RAT Apoptosis regulator Bcl-X (Bcl-2-like 1 ... 45 2e-04
sp|Q64373|BCLX_MOUSE Apoptosis regulator Bcl-X (Bcl-2-like ... 45 2e-04
sp|Q07817|BCLX_HUMAN Apoptosis regulator Bcl-X (Bcl-2-like ... 44 2e-04
>sp|Q16611|BAK_HUMAN Bcl-2 homologous antagonist/killer (Apoptosis regulator BAK)
(Bcl-2-like 7 protein)
Length = 211
Score = 67.8 bits (164), Expect = 2e-11
Identities = 46/148 (31%), Positives = 75/148 (50%), Gaps = 1/148 (0%)
Frame = +2
Query: 14 PENKDSVSWQIGKKLASIADKLALDESSKGLIKEIVTLV-NVGPDDSGAFKEFSEIAKKV 190
P S Q+G++LA I D + ++ E T++ ++ P A++ F++IA +
Sbjct: 64 PLQPSSTMGQVGRQLAIIGDDI-----NRRYDSEFQTMLQHLQPTAENAYEYFTKIATSL 118
Query: 191 IEGGISWKNVATLFYFGYRIARDRLTKGVQHFLSQLLQWIIDIFKGLGIFKWIISNGGWR 370
E GI+W V L FGYR+A G+ FL Q+ ++++D I +WI GGW
Sbjct: 119 FESGINWGRVVALLGFGYRLALHVYQHGLTGFLGQVTRFVVDFMLHHCIARWIAQRGGWV 178
Query: 371 DFLGNDSDDGNVYSALVYPSVVVGVVAL 454
L + +G + + L VV+GVV L
Sbjct: 179 AAL--NLGNGPILNVL----VVLGVVLL 200
>sp|Q13014|BAK2_HUMAN Putative Bcl-2 homologous antagonist/killer 2 (Apoptosis regulator
BAK-2)
Length = 211
Score = 67.0 bits (162), Expect = 3e-11
Identities = 45/148 (30%), Positives = 75/148 (50%), Gaps = 1/148 (0%)
Frame = +2
Query: 14 PENKDSVSWQIGKKLASIADKLALDESSKGLIKEIVTLV-NVGPDDSGAFKEFSEIAKKV 190
P S Q+G++LA I D + ++ E T++ ++ P A++ F++IA +
Sbjct: 64 PLQPSSTMGQVGRQLAIIGDDI-----NRRYDSEFQTMLQHLQPTAENAYEYFTKIASSL 118
Query: 191 IEGGISWKNVATLFYFGYRIARDRLTKGVQHFLSQLLQWIIDIFKGLGIFKWIISNGGWR 370
E GI+W V L F YR+A +G+ FL Q+ ++++D I +WI GGW
Sbjct: 119 FESGINWGRVVALLGFSYRLALHIYQRGLTGFLGQVTRFVVDFMLHHCIARWIAQRGGWV 178
Query: 371 DFLGNDSDDGNVYSALVYPSVVVGVVAL 454
L + +G + + L VV+GVV L
Sbjct: 179 AAL--NLGNGPILNVL----VVLGVVLL 200
>sp|O08734|BAK_MOUSE Bcl-2 homologous antagonist/killer (Apoptosis regulator BAK)
Length = 208
Score = 65.9 bits (159), Expect = 7e-11
Identities = 38/124 (30%), Positives = 64/124 (51%), Gaps = 2/124 (1%)
Frame = +2
Query: 2 LPHAPENKDSVSWQIGKKLASIADKL--ALDESSKGLIKEIVTLVNVGPDDSGAFKEFSE 175
+ + P +S+ Q+G++LA I D + D + L++++ P A++ F++
Sbjct: 57 MDNLPLEPNSILGQVGRQLALIGDDINRRYDTEFQNLLEQLQ------PTAGNAYELFTK 110
Query: 176 IAKKVIEGGISWKNVATLFYFGYRIARDRLTKGVQHFLSQLLQWIIDIFKGLGIFKWIIS 355
IA + + GISW V L FGYR+A +G+ FL Q+ ++ DI I +WI
Sbjct: 111 IASSLFKSGISWGRVVALLGFGYRLALYVYQRGLTGFLGQVTCFLADIILHHYIARWIAQ 170
Query: 356 NGGW 367
GGW
Sbjct: 171 RGGW 174
>sp|Q91827|AR1_XENLA Apoptosis regulator R1 (XR1)
Length = 228
Score = 60.8 bits (146), Expect = 2e-09
Identities = 32/122 (26%), Positives = 59/122 (48%)
Frame = +2
Query: 14 PENKDSVSWQIGKKLASIADKLALDESSKGLIKEIVTLVNVGPDDSGAFKEFSEIAKKVI 193
PE + S + + + D+ +E + EI T ++V P A+ F+E+A +
Sbjct: 67 PEPSGAASCALHSAMRAAGDEF--EERFRQAFSEISTQIHVTPGT--AYARFAEVAGSLF 122
Query: 194 EGGISWKNVATLFYFGYRIARDRLTKGVQHFLSQLLQWIIDIFKGLGIFKWIISNGGWRD 373
+GG++W + F FG + + + K + L ++ W++ + + WI SNGGW
Sbjct: 123 QGGVNWGRIVAFFVFGAALCAESVNKEMSPLLPRIQDWMVTYLE-TNLRDWIQSNGGWNG 181
Query: 374 FL 379
FL
Sbjct: 182 FL 183
>sp|Q91828|AR11_XENLA Apoptosis regulator R11 (XR11)
Length = 204
Score = 50.1 bits (118), Expect = 4e-06
Identities = 25/111 (22%), Positives = 51/111 (45%), Gaps = 8/111 (7%)
Frame = +2
Query: 155 AFKEFSEIAKKVIEGGISWKNVATLFYFGYRIARDRLTKGVQHFLSQLLQWIIDIFKGLG 334
A + F ++ ++ G +W + F FG + + K + L +++QW+++ +
Sbjct: 91 AQQSFQQVMGELFRDGTNWGRIVAFFSFGRALCVESANKEMTDLLPRIVQWMVNYLEHT- 149
Query: 335 IFKWIISNGGWRDFLG--------NDSDDGNVYSALVYPSVVVGVVALICY 463
+ W+ NGGW F+G + + L+ ++ GV AL+CY
Sbjct: 150 LQPWMQENGGWEAFVGLYGKNAAAQSRESQERFGRLLTIVMLTGVFALVCY 200
>sp|Q92843|BCLW_HUMAN Apoptosis regulator Bcl-W (Bcl-2-like 2 protein)
Length = 193
Score = 47.0 bits (110), Expect = 3e-05
Identities = 18/74 (24%), Positives = 42/74 (56%)
Frame = +2
Query: 155 AFKEFSEIAKKVIEGGISWKNVATLFYFGYRIARDRLTKGVQHFLSQLLQWIIDIFKGLG 334
A + F++++ ++ +GG +W + F FG + + + K ++ + Q+ +W++ +
Sbjct: 75 AQQRFTQVSDELFQGGPNWGRLVAFFVFGAALCAESVNKEMEPLVGQVQEWMV-AYLETR 133
Query: 335 IFKWIISNGGWRDF 376
+ WI S+GGW +F
Sbjct: 134 LADWIHSSGGWAEF 147
>sp|P70345|BCLW_MOUSE Apoptosis regulator Bcl-W (Bcl-2-like 2 protein) (c98)
Length = 193
Score = 46.2 bits (108), Expect = 5e-05
Identities = 18/74 (24%), Positives = 41/74 (55%)
Frame = +2
Query: 155 AFKEFSEIAKKVIEGGISWKNVATLFYFGYRIARDRLTKGVQHFLSQLLQWIIDIFKGLG 334
A + F++++ ++ +GG +W + F FG + + + K ++ + Q+ W++ +
Sbjct: 75 AQQRFTQVSDELFQGGPNWGRLVAFFVFGAALCAESVNKEMEPLVGQVQDWMV-AYLETR 133
Query: 335 IFKWIISNGGWRDF 376
+ WI S+GGW +F
Sbjct: 134 LADWIHSSGGWAEF 147
>sp|P53563|BCLX_RAT Apoptosis regulator Bcl-X (Bcl-2-like 1 protein)
Length = 233
Score = 44.7 bits (104), Expect = 2e-04
Identities = 18/75 (24%), Positives = 37/75 (49%)
Frame = +2
Query: 155 AFKEFSEIAKKVIEGGISWKNVATLFYFGYRIARDRLTKGVQHFLSQLLQWIIDIFKGLG 334
A++ F ++ ++ G++W + F FG + + + K +Q +S++ W+
Sbjct: 119 AYQSFEQVVNELFRDGVNWGRIVAFFSFGGALCVESVDKEMQVLVSRIASWMATYLND-H 177
Query: 335 IFKWIISNGGWRDFL 379
+ WI NGGW F+
Sbjct: 178 LEPWIQENGGWDTFV 192
>sp|Q64373|BCLX_MOUSE Apoptosis regulator Bcl-X (Bcl-2-like 1 protein)
Length = 233
Score = 44.7 bits (104), Expect = 2e-04
Identities = 18/75 (24%), Positives = 37/75 (49%)
Frame = +2
Query: 155 AFKEFSEIAKKVIEGGISWKNVATLFYFGYRIARDRLTKGVQHFLSQLLQWIIDIFKGLG 334
A++ F ++ ++ G++W + F FG + + + K +Q +S++ W+
Sbjct: 119 AYQSFEQVVNELFRDGVNWGRIVAFFSFGGALCVESVDKEMQVLVSRIASWMATYLND-H 177
Query: 335 IFKWIISNGGWRDFL 379
+ WI NGGW F+
Sbjct: 178 LEPWIQENGGWDTFV 192
>sp|Q07817|BCLX_HUMAN Apoptosis regulator Bcl-X (Bcl-2-like 1 protein)
Length = 233
Score = 44.3 bits (103), Expect = 2e-04
Identities = 18/75 (24%), Positives = 37/75 (49%)
Frame = +2
Query: 155 AFKEFSEIAKKVIEGGISWKNVATLFYFGYRIARDRLTKGVQHFLSQLLQWIIDIFKGLG 334
A++ F ++ ++ G++W + F FG + + + K +Q +S++ W+
Sbjct: 119 AYQSFEQVVNELFRDGVNWGRIVAFFSFGGALCVESVDKEMQVLVSRIAAWMATYLND-H 177
Query: 335 IFKWIISNGGWRDFL 379
+ WI NGGW F+
Sbjct: 178 LEPWIQENGGWDTFV 192
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 59,624,308
Number of Sequences: 369166
Number of extensions: 1171357
Number of successful extensions: 3297
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 3230
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 3284
length of database: 68,354,980
effective HSP length: 104
effective length of database: 49,142,540
effective search space used: 3980545740
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)