Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_026_F17
(569 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q26636|CATL_SARPE Cathepsin L precursor [Contains: Cathe... 191 8e-49
sp|Q95029|CATL_DROME Cathepsin L precursor (Cysteine protei... 191 8e-49
sp|P25782|CYSP2_HOMAM Digestive cysteine proteinase 2 precu... 189 3e-48
sp|Q10991|CATL_SHEEP Cathepsin L [Contains: Cathepsin L hea... 187 2e-47
sp|P07711|CATL_HUMAN Cathepsin L precursor (Major excreted ... 182 4e-46
sp|P25975|CATL_BOVIN Cathepsin L precursor [Contains: Cathe... 182 5e-46
sp|O60911|CATL2_HUMAN Cathepsin L2 precursor (Cathepsin V) ... 181 1e-45
sp|Q9GL24|CATL_CANFA Cathepsin L precursor [Contains: Cathe... 181 1e-45
sp|P25784|CYSP3_HOMAM Digestive cysteine proteinase 3 precu... 179 3e-45
sp|P07154|CATL_RAT Cathepsin L precursor (Major excreted pr... 177 1e-44
>sp|Q26636|CATL_SARPE Cathepsin L precursor [Contains: Cathepsin L heavy chain; Cathepsin
L light chain]
Length = 339
Score = 191 bits (486), Expect = 8e-49
Identities = 95/166 (57%), Positives = 110/166 (66%), Gaps = 2/166 (1%)
Frame = +3
Query: 9 LVDCSXXXXXXXXXXXLMDNAFRYIKDQG-IESEGDYPYTATDGTCKRNPSKIVTKCTGF 185
LVDCS LMDNAFRYIKD G I++E YPY D +C N + I TGF
Sbjct: 174 LVDCSTKYGNNGCNGGLMDNAFRYIKDNGGIDTEKSYPYEGIDDSCHFNKATIGATDTGF 233
Query: 186 TDIQSQNETDLANAVATVGPVSVAIDAGHASFQLYKSGIYNEESCSTTQLDHGVLAVGYG 365
DI +E + AVAT+GPVSVAIDA H SFQLY G+YNE C LDHGVL VGYG
Sbjct: 234 VDIPEGDEEKMKKAVATMGPVSVAIDASHESFQLYSEGVYNEPECDEQNLDHGVLVVGYG 293
Query: 366 T-QIGKKYWIVKNSWDVTWGESGYIKMSKDKKNQCGIATMASYPLV 500
T + G YW+VKNSW TWGE GYIKM++++ NQCGIAT +SYP V
Sbjct: 294 TDESGMDYWLVKNSWGTTWGEQGYIKMARNQNNQCGIATASSYPTV 339
>sp|Q95029|CATL_DROME Cathepsin L precursor (Cysteine proteinase 1) [Contains: Cathepsin
L heavy chain; Cathepsin L light chain]
Length = 341
Score = 191 bits (486), Expect = 8e-49
Identities = 94/166 (56%), Positives = 112/166 (67%), Gaps = 2/166 (1%)
Frame = +3
Query: 9 LVDCSXXXXXXXXXXXLMDNAFRYIKDQG-IESEGDYPYTATDGTCKRNPSKIVTKCTGF 185
LVDCS LMDNAFRYIKD G I++E YPY A D +C N + GF
Sbjct: 176 LVDCSTKYGNNGCNGGLMDNAFRYIKDNGGIDTEKSYPYEAIDDSCHFNKGTVGATDRGF 235
Query: 186 TDIQSQNETDLANAVATVGPVSVAIDAGHASFQLYKSGIYNEESCSTTQLDHGVLAVGYG 365
TDI +E +A AVATVGPVSVAIDA H SFQ Y G+YNE C LDHGVL VG+G
Sbjct: 236 TDIPQGDEKKMAEAVATVGPVSVAIDASHESFQFYSEGVYNEPQCDAQNLDHGVLVVGFG 295
Query: 366 T-QIGKKYWIVKNSWDVTWGESGYIKMSKDKKNQCGIATMASYPLV 500
T + G+ YW+VKNSW TWG+ G+IKM ++K+NQCGIA+ +SYPLV
Sbjct: 296 TDESGEDYWLVKNSWGTTWGDKGFIKMLRNKENQCGIASASSYPLV 341
>sp|P25782|CYSP2_HOMAM Digestive cysteine proteinase 2 precursor
Length = 323
Score = 189 bits (481), Expect = 3e-48
Identities = 88/166 (53%), Positives = 118/166 (71%), Gaps = 1/166 (0%)
Frame = +3
Query: 6 QLVDCSXXXXXXXXXXXLMDNAFRYIK-DQGIESEGDYPYTATDGTCKRNPSKIVTKCTG 182
QLVDCS M++AF YIK + GI++E YPY A DG+C+ + + + C+G
Sbjct: 158 QLVDCSRPYGPQGCNGGWMNDAFDYIKANNGIDTEAAYPYEARDGSCRFDSNSVAATCSG 217
Query: 183 FTDIQSQNETDLANAVATVGPVSVAIDAGHASFQLYKSGIYNEESCSTTQLDHGVLAVGY 362
T+I S +ET L AV +GP+SV IDA H+SFQ Y SG+Y E SCS + LDH VLAVGY
Sbjct: 218 HTNIASGSETGLQQAVRDIGPISVTIDAAHSSFQFYSSGVYYEPSCSPSYLDHAVLAVGY 277
Query: 363 GTQIGKKYWIVKNSWDVTWGESGYIKMSKDKKNQCGIATMASYPLV 500
G++ G+ +W+VKNSW +WG++GYIKMS+++ N CGIAT+ASYPLV
Sbjct: 278 GSEGGQDFWLVKNSWATSWGDAGYIKMSRNRNNNCGIATVASYPLV 323
>sp|Q10991|CATL_SHEEP Cathepsin L [Contains: Cathepsin L heavy chain; Cathepsin L light
chain]
Length = 217
Score = 187 bits (474), Expect = 2e-47
Identities = 96/166 (57%), Positives = 110/166 (66%), Gaps = 2/166 (1%)
Frame = +3
Query: 9 LVDCSXXXXXXXXXXXLMDNAFRYIKDQG-IESEGDYPYTATDGTCKRNPSKIVTKCTGF 185
LVD S LMDNAF+YIK+ G ++SE YPY ATD +C P K TGF
Sbjct: 53 LVDSSRPQGNQGCNGGLMDNAFQYIKENGGLDSEESYPYEATDTSCNYKPEYSAAKDTGF 112
Query: 186 TDIQSQNETDLANAVATVGPVSVAIDAGHASFQLYKSGIYNEESCSTTQLDHGVLAVGYG 365
DI Q E L AVATVGP+SVAIDAGH+SFQ YKSGIY + CS+ LDHGVL VGYG
Sbjct: 113 VDIP-QREKALMKAVATVGPISVAIDAGHSSFQFYKSGIYYDPDCSSKDLDHGVLVVGYG 171
Query: 366 TQ-IGKKYWIVKNSWDVTWGESGYIKMSKDKKNQCGIATMASYPLV 500
+ K+WIVKNSW WG GY+KM+KD+ N CGIAT ASYP V
Sbjct: 172 FEGTNNKFWIVKNSWGPEWGNKGYVKMAKDQNNHCGIATAASYPTV 217
>sp|P07711|CATL_HUMAN Cathepsin L precursor (Major excreted protein) (MEP) [Contains:
Cathepsin L heavy chain; Cathepsin L light chain]
Length = 333
Score = 182 bits (463), Expect = 4e-46
Identities = 93/169 (55%), Positives = 110/169 (65%), Gaps = 5/169 (2%)
Frame = +3
Query: 9 LVDCSXXXXXXXXXXXLMDNAFRYIKDQG-IESEGDYPYTATDGTCKRNPSKIVTKCTGF 185
LVDCS LMD AF+Y++D G ++SE YPY AT+ +CK NP V TGF
Sbjct: 166 LVDCSGPQGNEGCNGGLMDYAFQYVQDNGGLDSEESYPYEATEESCKYNPKYSVANDTGF 225
Query: 186 TDIQSQNETDLANAVATVGPVSVAIDAGHASFQLYKSGIYNEESCSTTQLDHGVLAVGYG 365
DI Q E L AVATVGP+SVAIDAGH SF YK GIY E CS+ +DHGVL VGYG
Sbjct: 226 VDIPKQ-EKALMKAVATVGPISVAIDAGHESFLFYKEGIYFEPDCSSEDMDHGVLVVGYG 284
Query: 366 TQI----GKKYWIVKNSWDVTWGESGYIKMSKDKKNQCGIATMASYPLV 500
+ KYW+VKNSW WG GY+KM+KD++N CGIA+ ASYP V
Sbjct: 285 FESTESDNNKYWLVKNSWGEEWGMGGYVKMAKDRRNHCGIASAASYPTV 333
>sp|P25975|CATL_BOVIN Cathepsin L precursor [Contains: Cathepsin L heavy chain; Cathepsin
L light chain]
Length = 334
Score = 182 bits (462), Expect = 5e-46
Identities = 97/170 (57%), Positives = 109/170 (64%), Gaps = 6/170 (3%)
Frame = +3
Query: 9 LVDCSXXXXXXXXXXXLMDNAFRYIKDQG-IESEGDYPYTATD-GTCKRNPSKIVTKCTG 182
LVDCS LMDNAF+YIKD G ++SE YPY ATD +C P TG
Sbjct: 166 LVDCSRAQGNQGCNGGLMDNAFQYIKDNGGLDSEESYPYLATDTNSCNYKPECSAANDTG 225
Query: 183 FTDIQSQNETDLANAVATVGPVSVAIDAGHASFQLYKSGIYNEESCSTTQLDHGVLAVGY 362
F DI Q E L AVATVGP+SVAIDAGH SFQ YKSGIY + CS LDHGVL VGY
Sbjct: 226 FVDIP-QREKALMKAVATVGPISVAIDAGHTSFQFYKSGIYYDPDCSCKDLDHGVLVVGY 284
Query: 363 GTQ----IGKKYWIVKNSWDVTWGESGYIKMSKDKKNQCGIATMASYPLV 500
G + K+WIVKNSW WG +GY+KM+KD+ N CGIAT ASYP V
Sbjct: 285 GFEGTDSNNNKFWIVKNSWGPEWGWNGYVKMAKDQNNHCGIATAASYPTV 334
>sp|O60911|CATL2_HUMAN Cathepsin L2 precursor (Cathepsin V) (Cathepsin U)
Length = 334
Score = 181 bits (459), Expect = 1e-45
Identities = 91/169 (53%), Positives = 106/169 (62%), Gaps = 5/169 (2%)
Frame = +3
Query: 9 LVDCSXXXXXXXXXXXLMDNAFRYIKDQG-IESEGDYPYTATDGTCKRNPSKIVTKCTGF 185
LVDCS M AF+Y+K+ G ++SE YPY A D CK P V TGF
Sbjct: 166 LVDCSRPQGNQGCNGGFMARAFQYVKENGGLDSEESYPYVAVDEICKYRPENSVANDTGF 225
Query: 186 TDIQSQNETDLANAVATVGPVSVAIDAGHASFQLYKSGIYNEESCSTTQLDHGVLAVGYG 365
T + E L AVATVGP+SVA+DAGH+SFQ YKSGIY E CS+ LDHGVL VGYG
Sbjct: 226 TVVAPGKEKALMKAVATVGPISVAMDAGHSSFQFYKSGIYFEPDCSSKNLDHGVLVVGYG 285
Query: 366 ----TQIGKKYWIVKNSWDVTWGESGYIKMSKDKKNQCGIATMASYPLV 500
KYW+VKNSW WG +GY+K++KDK N CGIAT ASYP V
Sbjct: 286 FEGANSNNSKYWLVKNSWGPEWGSNGYVKIAKDKNNHCGIATAASYPNV 334
>sp|Q9GL24|CATL_CANFA Cathepsin L precursor [Contains: Cathepsin L heavy chain; Cathepsin
L light chain]
Length = 333
Score = 181 bits (459), Expect = 1e-45
Identities = 95/169 (56%), Positives = 108/169 (63%), Gaps = 5/169 (2%)
Frame = +3
Query: 9 LVDCSXXXXXXXXXXXLMDNAFRYIKDQG-IESEGDYPYTATDG-TCKRNPSKIVTKCTG 182
LVDCS LMDNAFRY+KD G ++SE YPY D TC P TG
Sbjct: 166 LVDCSRAQGNEGCNGGLMDNAFRYVKDNGGLDSEESYPYLGRDTETCNYKPECSAANDTG 225
Query: 183 FTDIQSQNETDLANAVATVGPVSVAIDAGHASFQLYKSGIYNEESCSTTQLDHGVLAVGY 362
F D+ Q E L AVAT+GP+SVAIDAGH SFQ YKSGIY + CS+ LDHGVL VGY
Sbjct: 226 FVDLP-QREKALMKAVATLGPISVAIDAGHQSFQFYKSGIYFDPDCSSKDLDHGVLVVGY 284
Query: 363 ---GTQIGKKYWIVKNSWDVTWGESGYIKMSKDKKNQCGIATMASYPLV 500
GT K+WIVKNSW WG +GY+KM+KD+ N CGIAT ASYP V
Sbjct: 285 GFEGTDSNNKFWIVKNSWGPEWGWNGYVKMAKDQNNHCGIATAASYPTV 333
>sp|P25784|CYSP3_HOMAM Digestive cysteine proteinase 3 precursor
Length = 321
Score = 179 bits (455), Expect = 3e-45
Identities = 89/166 (53%), Positives = 112/166 (67%), Gaps = 1/166 (0%)
Frame = +3
Query: 6 QLVDCSXXXXXXXXXXXLMDNAFRYIKDQG-IESEGDYPYTATDGTCKRNPSKIVTKCTG 182
QLVDCS M +AF YIKD G I++E YPY A D +C+ + + I CTG
Sbjct: 157 QLVDCSTDYGNDGCGGGWMTSAFDYIKDNGGIDTESSYPYEAEDRSCRFDANSIGAICTG 216
Query: 183 FTDIQSQNETDLANAVATVGPVSVAIDAGHASFQLYKSGIYNEESCSTTQLDHGVLAVGY 362
++Q E L AV+ VGP+SVAIDA H SFQ Y SG+Y E++CS T LDHGVLAVGY
Sbjct: 217 SVEVQHTEEA-LQEAVSGVGPISVAIDASHFSFQFYSSGVYYEQNCSPTFLDHGVLAVGY 275
Query: 363 GTQIGKKYWIVKNSWDVTWGESGYIKMSKDKKNQCGIATMASYPLV 500
GT+ K YW+VKNSW +WG++GYIKMS+++ N CGIA+ SYP V
Sbjct: 276 GTESTKDYWLVKNSWGSSWGDAGYIKMSRNRDNNCGIASEPSYPTV 321
>sp|P07154|CATL_RAT Cathepsin L precursor (Major excreted protein) (MEP) (Cyclic
protein 2) (CP-2) [Contains: Cathepsin L heavy chain;
Cathepsin L light chain]
Length = 334
Score = 177 bits (450), Expect = 1e-44
Identities = 94/169 (55%), Positives = 109/169 (64%), Gaps = 5/169 (2%)
Frame = +3
Query: 9 LVDCSXXXXXXXXXXXLMDNAFRYIKDQG-IESEGDYPYTATDGTCKRNPSKIVTKCTGF 185
LVDCS LMD AF+YIK+ G ++SE YPY A DG+CK V TGF
Sbjct: 166 LVDCSHDQGNQGCNGGLMDFAFQYIKENGGLDSEESYPYEAKDGSCKYRAEYAVANDTGF 225
Query: 186 TDIQSQNETDLANAVATVGPVSVAIDAGHASFQLYKSGIYNEESCSTTQLDHGVLAVGY- 362
DI Q E L AVATVGP+SVA+DA H S Q Y SGIY E +CS+ LDHGVL VGY
Sbjct: 226 VDIPQQ-EKALMKAVATVGPISVAMDASHPSLQFYSSGIYYEPNCSSKDLDHGVLVVGYG 284
Query: 363 --GTQIGK-KYWIVKNSWDVTWGESGYIKMSKDKKNQCGIATMASYPLV 500
GT K KYW+VKNSW WG GYIK++KD+ N CG+AT ASYP+V
Sbjct: 285 YEGTDSNKDKYWLVKNSWGKEWGMDGYIKIAKDRNNHCGLATAASYPIV 333
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 62,213,597
Number of Sequences: 369166
Number of extensions: 1237769
Number of successful extensions: 3820
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 3427
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 3503
length of database: 68,354,980
effective HSP length: 104
effective length of database: 49,142,540
effective search space used: 4177115900
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)