Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_026_B11
(878 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q9NWZ5|UCKL1_HUMAN Uridine/cytidine kinase-like 1 293 3e-79
sp|Q91YL3|UCKL1_MOUSE Uridine/cytidine kinase-like 1 291 1e-78
sp|Q26998|UPP_TOXGO Uracil phosphoribosyltransferase (UMP p... 184 3e-46
sp|P18562|UPP_YEAST Uracil phosphoribosyltransferase (UMP p... 180 5e-45
sp|O13867|UPP1_SCHPO Probable uracil phosphoribosyltransfer... 179 7e-45
sp|O65583|UPP_ARATH Uracil phosphoribosyltransferase (UMP p... 171 2e-42
sp|Q9HE15|UPP2_SCHPO Probable uracil phosphoribosyltransfer... 150 3e-36
sp|P27515|URK1_YEAST Uridine kinase (Uridine monophosphokin... 132 1e-30
sp|Q8EM74|UPP_OCEIH Uracil phosphoribosyltransferase (UMP p... 98 3e-20
sp|P39149|UPP_BACSU Uracil phosphoribosyltransferase (UMP p... 95 3e-19
>sp|Q9NWZ5|UCKL1_HUMAN Uridine/cytidine kinase-like 1
Length = 548
Score = 293 bits (751), Expect = 3e-79
Identities = 153/269 (56%), Positives = 194/269 (72%)
Frame = +3
Query: 3 FIAPCMEHADIIIPRGGQNDVAVNVIVQHVTKQLLLRGKHIRFLQAHCNQDMNISEIKSL 182
+I P M ADI++PRG N VA+N+IVQHV QL R +R A +Q + ++L
Sbjct: 267 YIQPTMRLADIVVPRGSGNTVAINLIVQHVHSQLEERELSVRAALASAHQCHPLP--RTL 324
Query: 183 HILKPTKQVRVLQTLIRNCNTPRDEFIFYSDRLMRLLSEFAASFLPFKDIIVHDSDNNQF 362
+LK T QVR + T+IR+ T RDEFIFYS RLMRLL E A SFLPF+D +V +
Sbjct: 325 SVLKSTPQVRGMHTIIRDKETSRDEFIFYSKRLMRLLIEHALSFLPFQDCVVQTPQGQDY 384
Query: 363 IGRVLDSESVCGVSVLRAGETMETALRDVCKDVKIGKILIQTNPDSHEPELHYSRLPKDI 542
G+ + + GVS+LRAGETME ALR VCKDV+IG ILIQTN + EPELHY RLPKDI
Sbjct: 385 AGKCYAGKQITGVSILRAGETMEPALRAVCKDVRIGTILIQTNQLTGEPELHYLRLPKDI 444
Query: 543 KNNHVILMDPTVASGAAAVMAIRVLLEHDVPEENIIMMSLLMAEQGVKTIAYNYSKVKII 722
++HVILMD TV++GAAA+MA+RVLL+HDVPE+ I ++SLLMAE GV ++AY + +V+II
Sbjct: 445 SDDHVILMDCTVSTGAAAMMAVRVLLDHDVPEDKIFLLSLLMAEMGVHSVAYAFPRVRII 504
Query: 723 AAAVDKVLTDEYHIQPGFGNFGNRYFGTD 809
AVDK + D + I PG GNFG+RYFGTD
Sbjct: 505 TTAVDKRVNDLFRIIPGIGNFGDRYFGTD 533
>sp|Q91YL3|UCKL1_MOUSE Uridine/cytidine kinase-like 1
Length = 548
Score = 291 bits (746), Expect = 1e-78
Identities = 152/269 (56%), Positives = 194/269 (72%)
Frame = +3
Query: 3 FIAPCMEHADIIIPRGGQNDVAVNVIVQHVTKQLLLRGKHIRFLQAHCNQDMNISEIKSL 182
+I P M ADI++PRG N VA+++IVQHV QL R +R A +Q + + +L
Sbjct: 267 YIQPTMRLADIVVPRGSGNTVAIDLIVQHVHSQLEERELSVRAALASAHQCHPLPQ--TL 324
Query: 183 HILKPTKQVRVLQTLIRNCNTPRDEFIFYSDRLMRLLSEFAASFLPFKDIIVHDSDNNQF 362
+LK T QVR + T+IR+ T RDEFIFYS RLMRLL E A SFLPF+D V +
Sbjct: 325 SVLKSTPQVRGMHTIIRDKETSRDEFIFYSKRLMRLLIEHALSFLPFQDCTVQTPQGQDY 384
Query: 363 IGRVLDSESVCGVSVLRAGETMETALRDVCKDVKIGKILIQTNPDSHEPELHYSRLPKDI 542
+G+ + + GVS+LRAGETME ALR VCKDV+IG ILIQTN + EPELHY RLPKDI
Sbjct: 385 VGKCYAGKQITGVSILRAGETMEPALRAVCKDVRIGTILIQTNQLTGEPELHYLRLPKDI 444
Query: 543 KNNHVILMDPTVASGAAAVMAIRVLLEHDVPEENIIMMSLLMAEQGVKTIAYNYSKVKII 722
++HVILMD TV++GAAA+MA+RVLL+HDVPE+ I ++SLLMAE GV ++AY + +V+II
Sbjct: 445 SDDHVILMDCTVSTGAAAMMAVRVLLDHDVPEDKIFLLSLLMAEMGVHSVAYAFPRVRII 504
Query: 723 AAAVDKVLTDEYHIQPGFGNFGNRYFGTD 809
AVDK + D + I PG GNFG+RYFGTD
Sbjct: 505 TTAVDKRVNDLFRIIPGIGNFGDRYFGTD 533
>sp|Q26998|UPP_TOXGO Uracil phosphoribosyltransferase (UMP pyrophosphorylase) (UPRTase)
(UPRT)
Length = 244
Score = 184 bits (467), Expect = 3e-46
Identities = 96/215 (44%), Positives = 144/215 (66%)
Frame = +3
Query: 162 ISEIKSLHILKPTKQVRVLQTLIRNCNTPRDEFIFYSDRLMRLLSEFAASFLPFKDIIVH 341
I+ ++ ++K T Q+R + T+IR+ TP++EF+FY+DRL+RLL E A + LPF+ V
Sbjct: 30 ITRFPNVVLMKQTAQLRAMMTIIRDKETPKEEFVFYADRLIRLLIEEALNELPFEKKEVT 89
Query: 342 DSDNNQFIGRVLDSESVCGVSVLRAGETMETALRDVCKDVKIGKILIQTNPDSHEPELHY 521
+ + G S+ +CGVS++RAGE+ME+ LR VC+ +IGKILIQ + + EP+L Y
Sbjct: 90 TPLDVSYHGVSFYSK-ICGVSIVRAGESMESGLRAVCRGCRIGKILIQRDETTAEPKLIY 148
Query: 522 SRLPKDIKNNHVILMDPTVASGAAAVMAIRVLLEHDVPEENIIMMSLLMAEQGVKTIAYN 701
+LP DI++ V+L+DP A+ + AI VLL V EE II +++L A QG++ +
Sbjct: 149 EKLPADIRDRWVMLLDPMCATAGSVCKAIEVLLRLGVKEERIIFVNILAAPQGIERVFKE 208
Query: 702 YSKVKIIAAAVDKVLTDEYHIQPGFGNFGNRYFGT 806
Y KV+++ AAVD L Y+I PG G+FG+RYFGT
Sbjct: 209 YPKVRMVTAAVDICLNSRYYIVPGIGDFGDRYFGT 243
>sp|P18562|UPP_YEAST Uracil phosphoribosyltransferase (UMP pyrophosphorylase) (UPRTase)
Length = 251
Score = 180 bits (456), Expect = 5e-45
Identities = 90/217 (41%), Positives = 142/217 (65%)
Frame = +3
Query: 150 QDMNISEIKSLHILKPTKQVRVLQTLIRNCNTPRDEFIFYSDRLMRLLSEFAASFLPFKD 329
Q M+ K++++L T Q+ L T+IRN NT R +FIFYSDR++RLL E + LP +
Sbjct: 34 QKMSSEPFKNVYLLPQTNQLLGLYTIIRNKNTTRPDFIFYSDRIIRLLVEEGLNHLPVQK 93
Query: 330 IIVHDSDNNQFIGRVLDSESVCGVSVLRAGETMETALRDVCKDVKIGKILIQTNPDSHEP 509
IV N F G V +CGVS++RAGE+ME LRD C+ V+IGKILIQ + ++ P
Sbjct: 94 QIVETDTNENFEG-VSFMGKICGVSIVRAGESMEQGLRDCCRSVRIGKILIQRDEETALP 152
Query: 510 ELHYSRLPKDIKNNHVILMDPTVASGAAAVMAIRVLLEHDVPEENIIMMSLLMAEQGVKT 689
+L Y +LP+DI +V L+DP +A+G +A+MA VL++ V E I ++L+ +++G++
Sbjct: 153 KLFYEKLPEDISERYVFLLDPMLATGGSAIMATEVLIKRGVKPERIYFLNLICSKEGIEK 212
Query: 690 IAYNYSKVKIIAAAVDKVLTDEYHIQPGFGNFGNRYF 800
+ +V+I+ A+D+ L + ++ PG G+FG+RY+
Sbjct: 213 YHAAFPEVRIVTGALDRGLDENKYLVPGLGDFGDRYY 249
>sp|O13867|UPP1_SCHPO Probable uracil phosphoribosyltransferase 1 (UMP pyrophosphorylase
1) (UPRTase 1)
Length = 219
Score = 179 bits (455), Expect = 7e-45
Identities = 83/215 (38%), Positives = 144/215 (66%)
Frame = +3
Query: 162 ISEIKSLHILKPTKQVRVLQTLIRNCNTPRDEFIFYSDRLMRLLSEFAASFLPFKDIIVH 341
+ E ++++L T Q++ L T+IR+ PR EFIFY++R++RL+ E + LP V
Sbjct: 4 VPEHGNVYVLNQTNQLKGLFTIIRDKTKPRSEFIFYANRIIRLIVEEGLNHLPVSSAKVT 63
Query: 342 DSDNNQFIGRVLDSESVCGVSVLRAGETMETALRDVCKDVKIGKILIQTNPDSHEPELHY 521
+ N ++ G + D +CGVS++RAGE+ME LR+ C+ V+IGKILIQ + ++H+P LHY
Sbjct: 64 TAQNAEYEGVMFDGR-ICGVSIMRAGESMEQGLRECCRSVRIGKILIQRDEETHKPVLHY 122
Query: 522 SRLPKDIKNNHVILMDPTVASGAAAVMAIRVLLEHDVPEENIIMMSLLMAEQGVKTIAYN 701
+LP+DI +V+L+DP +A+G +A+ A+ +L+ +E II ++++ + +G+K +
Sbjct: 123 IKLPEDISKRYVLLLDPMLATGGSAICAMEILINMGCKQEQIIFLNVIASPEGLKNVHDR 182
Query: 702 YSKVKIIAAAVDKVLTDEYHIQPGFGNFGNRYFGT 806
+ ++I+ A +D+ L + +I PG G+FG+ YFGT
Sbjct: 183 FPNIRIVTAVIDEGLDNNGYIVPGLGDFGDIYFGT 217
>sp|O65583|UPP_ARATH Uracil phosphoribosyltransferase (UMP pyrophosphorylase) (UPRTase)
Length = 198
Score = 171 bits (434), Expect = 2e-42
Identities = 88/198 (44%), Positives = 128/198 (64%)
Frame = +3
Query: 216 LQTLIRNCNTPRDEFIFYSDRLMRLLSEFAASFLPFKDIIVHDSDNNQFIGRVLDSESVC 395
+ TLIR+ T + +F+FYSDRL+RL+ E LPF + V + G V + +C
Sbjct: 1 MHTLIRDSQTTKHDFVFYSDRLIRLVVEHGLGHLPFTEKQVITPTGCVYSG-VDFCKRLC 59
Query: 396 GVSVLRAGETMETALRDVCKDVKIGKILIQTNPDSHEPELHYSRLPKDIKNNHVILMDPT 575
GVSV+R+GE+ME ALR CK +KIGKILI D+ + +L Y +LP DI HV+L+DP
Sbjct: 60 GVSVIRSGESMENALRACCKGIKIGKILIHREGDNGQ-QLVYEKLPNDISERHVLLLDPI 118
Query: 576 VASGAAAVMAIRVLLEHDVPEENIIMMSLLMAEQGVKTIAYNYSKVKIIAAAVDKVLTDE 755
+ +G +AV AI +L+ VPE NII ++L+ A QGV + + ++KI+ + +D L +E
Sbjct: 119 LGTGNSAVEAINLLISKGVPEGNIIFLNLISAPQGVHVVCKKFPRIKIVTSEIDNGLNEE 178
Query: 756 YHIQPGFGNFGNRYFGTD 809
+ + PG G FG+RYFGTD
Sbjct: 179 FRVIPGMGEFGDRYFGTD 196
>sp|Q9HE15|UPP2_SCHPO Probable uracil phosphoribosyltransferase 2 (UMP pyrophosphorylase
2) (UPRTase 2)
Length = 220
Score = 150 bits (380), Expect = 3e-36
Identities = 71/216 (32%), Positives = 135/216 (62%), Gaps = 1/216 (0%)
Frame = +3
Query: 162 ISEIKSLHILKPTKQVRVLQTLIRNCNTPRDEFIFYSDRLMRLLSEFAASFLPFKDIIVH 341
+ + +++ +L+ T + L T++R+ T EF+ ++ ++ +L + A S LP+K ++
Sbjct: 5 LEQPENVVVLRQTMYLLSLMTILRDQQTGHSEFVRTANLIINMLMQEALSALPYKKCLIK 64
Query: 342 DSDNNQFIGRVLDSESVCGVSVLRAGETMETALRDVCK-DVKIGKILIQTNPDSHEPELH 518
S + G V + +CGVS+LRAGE+ME L C V +GK+L+Q + + E +L
Sbjct: 65 TSSGGTYTG-VQPARDICGVSILRAGESMEYGLAAACNYSVPVGKLLVQRDETTFEAKLM 123
Query: 519 YSRLPKDIKNNHVILMDPTVASGAAAVMAIRVLLEHDVPEENIIMMSLLMAEQGVKTIAY 698
+ +LPKD ++ V+L+DP +A+G + ++AI+ L+ +PEENI+ ++L+ +G+ +
Sbjct: 124 FCKLPKDAQDRLVLLLDPLLATGNSVILAIQTLINKGIPEENIVFVNLIACNEGITNVFA 183
Query: 699 NYSKVKIIAAAVDKVLTDEYHIQPGFGNFGNRYFGT 806
+ K++++ A++D L ++ PG G+FG+RYFGT
Sbjct: 184 KFPKLRMVTASIDPELNANKYVVPGCGDFGDRYFGT 219
>sp|P27515|URK1_YEAST Uridine kinase (Uridine monophosphokinase)
Length = 501
Score = 132 bits (333), Expect = 1e-30
Identities = 90/278 (32%), Positives = 149/278 (53%), Gaps = 9/278 (3%)
Frame = +3
Query: 3 FIAPCMEHADIIIPRGGQNDVAVNVIVQHVTKQLLLRG-KHIR-FLQAHCNQDMNISEIK 176
F+ P M++AD IIP N AVN+I+ H+ +L L+ +H+R ++ + ++
Sbjct: 226 FVKPTMKNADAIIPSMSDNATAVNLIINHIKSKLELKSNEHLRELIKLGSSPSQDVLNRN 285
Query: 177 SLHILKPTKQVRVLQTLIRNCNTPRDEFIFYSDRLMRLLSEFAASFLPFKDI-IVHDSDN 353
+H L PT QV L T++ N N +F+FY DRL +L +A +P I+ ++
Sbjct: 286 IIHELPPTNQVLSLHTMLLNKNLNCADFVFYFDRLATILLSWALDDIPVAHTNIITPGEH 345
Query: 354 NQFIGRVLDSESVCGVSVLRAGETMETALRDVCKDVKIGKILIQTNPDSHEPELHYSRLP 533
+ V V+++R+G+ +LR ++ IGK+LIQ++ + EP+LH LP
Sbjct: 346 TMENVIACQFDQVTAVNIIRSGDCFMKSLRKTIPNITIGKLLIQSDSQTGEPQLHCEFLP 405
Query: 534 KDI-KNNHVILMDPTVASGAAAVMAIRVLLEHDVPEENIIMMSLLMAEQGVKTIAYNY-S 707
+I K V LM+ + SGAA +MAI+VLL+H + E I ++ L E G++ I + +
Sbjct: 406 PNIEKFGKVFLMEGQIISGAAMIMAIQVLLDHGIDLEKISVVVYLATEVGIRRILNAFDN 465
Query: 708 KVKIIAAAV---DKVLTDEYH-IQPGFGNFGNRYFGTD 809
KV I A + +K+ +Y F F ++YFG D
Sbjct: 466 KVNIFAGMIISREKLQNHQYKWALTRF--FDSKYFGCD 501
>sp|Q8EM74|UPP_OCEIH Uracil phosphoribosyltransferase (UMP pyrophosphorylase) (UPRTase)
Length = 209
Score = 97.8 bits (242), Expect = 3e-20
Identities = 63/195 (32%), Positives = 106/195 (54%)
Frame = +3
Query: 222 TLIRNCNTPRDEFIFYSDRLMRLLSEFAASFLPFKDIIVHDSDNNQFIGRVLDSESVCGV 401
T IR+ NT EF D + L++ LP K++ V D+ +VL + + V
Sbjct: 17 TYIRDKNTGTKEFRELVDEVAMLMAFEITRDLPVKEVNV-DTPVTTAPSKVLAGKKLGLV 75
Query: 402 SVLRAGETMETALRDVCKDVKIGKILIQTNPDSHEPELHYSRLPKDIKNNHVILMDPTVA 581
+LRAG M +R + K+G + + +P++ +P +Y +LP DI+ +I++DP +A
Sbjct: 76 PILRAGLGMVDGVRKLIPAAKVGHVGLYRDPETFKPVEYYVKLPNDIEEREIIVIDPMLA 135
Query: 582 SGAAAVMAIRVLLEHDVPEENIIMMSLLMAEQGVKTIAYNYSKVKIIAAAVDKVLTDEYH 761
+G +A AI + + +NI +M L+ A +GV+ + + V I AA+D+ L D +
Sbjct: 136 TGGSANDAIAAIKKRGA--KNIRLMCLIAAPEGVEVVKEAHPDVDIYLAAMDERLDDHGY 193
Query: 762 IQPGFGNFGNRYFGT 806
I PG G+ G+R FGT
Sbjct: 194 IIPGLGDAGDRLFGT 208
>sp|P39149|UPP_BACSU Uracil phosphoribosyltransferase (UMP pyrophosphorylase) (UPRTase)
Length = 209
Score = 94.7 bits (234), Expect = 3e-19
Identities = 59/195 (30%), Positives = 107/195 (54%)
Frame = +3
Query: 222 TLIRNCNTPRDEFIFYSDRLMRLLSEFAASFLPFKDIIVHDSDNNQFIGRVLDSESVCGV 401
T IRN NT +F D + L++ LP +++ ++ + +V+ + + V
Sbjct: 17 TYIRNENTGTKDFRELVDEVATLMAFEITRDLPLEEVDIN-TPVQAAKSKVISGKKLGVV 75
Query: 402 SVLRAGETMETALRDVCKDVKIGKILIQTNPDSHEPELHYSRLPKDIKNNHVILMDPTVA 581
+LRAG M + + K+G + + +P++ +P +Y +LP D++ I++DP +A
Sbjct: 76 PILRAGLGMVDGILKLIPAAKVGHVGLYRDPETLKPVEYYVKLPSDVEEREFIVVDPMLA 135
Query: 582 SGAAAVMAIRVLLEHDVPEENIIMMSLLMAEQGVKTIAYNYSKVKIIAAAVDKVLTDEYH 761
+G +AV AI L + +NI M L+ A +GV+ + ++S V I AA+D+ L ++ +
Sbjct: 136 TGGSAVEAIHSLKKRGA--KNIRFMCLVAAPEGVEELQKHHSDVDIYIAALDEKLNEKGY 193
Query: 762 IQPGFGNFGNRYFGT 806
I PG G+ G+R FGT
Sbjct: 194 IVPGLGDAGDRMFGT 208
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 90,404,955
Number of Sequences: 369166
Number of extensions: 1674800
Number of successful extensions: 5015
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 4811
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 4935
length of database: 68,354,980
effective HSP length: 110
effective length of database: 48,034,130
effective search space used: 8742211660
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)