Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_026_B02
(864 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|O60518|RNBP6_HUMAN Ran-binding protein 6 (RanBP6) 199 6e-51
sp|O00410|IMB3_HUMAN Importin beta-3 (Karyopherin beta-3) (... 199 1e-50
sp|Q8BIV3|RNBP6_MOUSE Ran-binding protein 6 (RanBP6) 196 7e-50
sp|Q8BKC5|IMB3_MOUSE Importin beta-3 (Karyopherin beta-3) (... 192 8e-49
sp|O74476|IMB3_SCHPO Importin beta-3 subunit 123 6e-28
sp|P32337|IMB3_YEAST Importin beta-3 subunit (Karyopherin b... 67 8e-11
sp|Q8VI75|IPO4_MOUSE Importin-4 (Importin 4a) (Imp4a) (Ran-... 54 4e-07
sp|Q8TEX9|IPO4_HUMAN Importin-4 (Importin 4b) (Imp4b) (Ran-... 50 8e-06
sp|P40069|IMB4_YEAST Importin beta-4 subunit (Karyopherin b... 45 3e-04
sp|P05527|HMIN_DROME Homeobox protein invected 32 3.0
>sp|O60518|RNBP6_HUMAN Ran-binding protein 6 (RanBP6)
Length = 1105
Score = 199 bits (507), Expect = 6e-51
Identities = 103/255 (40%), Positives = 164/255 (64%), Gaps = 4/255 (1%)
Frame = +3
Query: 9 DLMHALFLVYKQDALPVFDQLLPNIMKLQEANRPWTDFQYCICFWDDMIESVGGNLSWQY 188
D++H+LF YK+ LP F+QLLP I+ L ++RPW D Q+ +C +DD+IE S++Y
Sbjct: 852 DILHSLFSTYKEKILPWFEQLLPLIVNLICSSRPWPDRQWGLCIFDDIIEHCSPT-SFKY 910
Query: 189 CQHYLPALIAGLRHDRKEIRQAAIYGFGLMAMHGGIEFTDVLREVAPILVELVETSCSRE 368
+++ ++ +R + E+RQAA YG G+MA GG ++ + E P+LV++++ + S+
Sbjct: 911 VEYFRWPMLLNMRDNNPEVRQAAAYGLGVMAQFGGDDYRSLCSEAVPLLVKVIKCANSKT 970
Query: 369 EELNMSTENAISALTKICKFRPDCVPGGSLDAFLPTWLSWLPIWEDSEETPHVFGFLCDL 548
++ ++TEN ISA+ KI KF+P+CV ++D LP WLSWLP+ ED EE FLCDL
Sbjct: 971 KKNVIATENCISAIGKILKFKPNCV---NVDEVLPHWLSWLPLHEDKEEAIQTLSFLCDL 1027
Query: 549 IENSNSVL----TSNLPHVIRSIAYCIMRDGLSEENPTFRRCLNLVKMVQANGDCFATCV 716
IE+++ V+ SNLP +I IA + + ++ E+P +R N+V+ VQ + D + CV
Sbjct: 1028 IESNHPVVIGPNNSNLPKIISIIAEGKINETINYEDPCAKRLANVVRQVQTSEDLWLECV 1087
Query: 717 NTLSKEEQAALQKAL 761
+ L E+Q ALQ+ L
Sbjct: 1088 SQLDDEQQEALQELL 1102
>sp|O00410|IMB3_HUMAN Importin beta-3 (Karyopherin beta-3) (Ran-binding protein 5) (RanBP5)
Length = 1097
Score = 199 bits (505), Expect = 1e-50
Identities = 101/255 (39%), Positives = 161/255 (63%), Gaps = 4/255 (1%)
Frame = +3
Query: 9 DLMHALFLVYKQDALPVFDQLLPNIMKLQEANRPWTDFQYCICFWDDMIESVGGNLSWQY 188
D++H++F YK+ LP F+QLLP I+ L +RPW D Q+ +C +DD+IE S++Y
Sbjct: 844 DILHSIFSSYKEKVLPWFEQLLPLIVNLICPHRPWPDRQWGLCIFDDVIEHCSP-ASFKY 902
Query: 189 CQHYLPALIAGLRHDRKEIRQAAIYGFGLMAMHGGIEFTDVLREVAPILVELVETSCSRE 368
+++L ++ + + E+RQAA YG G+MA +GG + E P+LV +++++ S+
Sbjct: 903 AEYFLRPMLQYVCDNSPEVRQAAAYGLGVMAQYGGDNYRPFCTEALPLLVRVIQSADSKT 962
Query: 369 EELNMSTENAISALTKICKFRPDCVPGGSLDAFLPTWLSWLPIWEDSEETPHVFGFLCDL 548
+E +TEN ISA+ KI KF+PDCV +++ LP WLSWLP+ ED EE F +LCDL
Sbjct: 963 KENVNATENCISAVGKIMKFKPDCV---NVEEVLPHWLSWLPLHEDKEEAVQTFNYLCDL 1019
Query: 549 IENSNSVL----TSNLPHVIRSIAYCIMRDGLSEENPTFRRCLNLVKMVQANGDCFATCV 716
IE+++ ++ +NLP + IA M + + E+P +R N+V+ VQ +G + C+
Sbjct: 1020 IESNHPIVLGPNNTNLPKIFSIIAEGEMHEAIKHEDPCAKRLANVVRQVQTSGGLWTECI 1079
Query: 717 NTLSKEEQAALQKAL 761
LS E+QAA+Q+ L
Sbjct: 1080 AQLSPEQQAAIQELL 1094
>sp|Q8BIV3|RNBP6_MOUSE Ran-binding protein 6 (RanBP6)
Length = 439
Score = 196 bits (498), Expect = 7e-50
Identities = 100/255 (39%), Positives = 162/255 (63%), Gaps = 4/255 (1%)
Frame = +3
Query: 9 DLMHALFLVYKQDALPVFDQLLPNIMKLQEANRPWTDFQYCICFWDDMIESVGGNLSWQY 188
D++H+LF YK+ LP F+QLLP I+ L ++RPW D Q+ +C +DD+IE S++Y
Sbjct: 186 DILHSLFSTYKEKILPWFEQLLPLIVNLICSSRPWPDRQWGLCIFDDIIEHCSPT-SFKY 244
Query: 189 CQHYLPALIAGLRHDRKEIRQAAIYGFGLMAMHGGIEFTDVLREVAPILVELVETSCSRE 368
+++ ++ +R + E+RQAA YG G+MA GG ++ + E P+LV++++ + S+
Sbjct: 245 VEYFRWPMLLNMRDNNPEVRQAAAYGLGVMAQFGGDDYRSLCSEAVPLLVKVIKCANSKT 304
Query: 369 EELNMSTENAISALTKICKFRPDCVPGGSLDAFLPTWLSWLPIWEDSEETPHVFGFLCDL 548
++ ++TEN ISA+ KI KF+P+CV ++D LP WLSWLP+ ED EE FLCDL
Sbjct: 305 KKNVIATENCISAIGKILKFKPNCV---NVDEVLPHWLSWLPLHEDKEEAIQTLNFLCDL 361
Query: 549 IENSNSVL----TSNLPHVIRSIAYCIMRDGLSEENPTFRRCLNLVKMVQANGDCFATCV 716
IE+++ V+ SNLP +I IA + + +S E+P +R N+V+ +Q + + + C
Sbjct: 362 IESNHPVVIGPNNSNLPKIISIIAEGKINETISHEDPCAKRLANVVRQIQTSEELWLECT 421
Query: 717 NTLSKEEQAALQKAL 761
+ L E+Q AL + L
Sbjct: 422 SQLDDEQQEALHELL 436
>sp|Q8BKC5|IMB3_MOUSE Importin beta-3 (Karyopherin beta-3) (Ran-binding protein 5) (RanBP5)
Length = 1097
Score = 192 bits (489), Expect = 8e-49
Identities = 97/255 (38%), Positives = 157/255 (61%), Gaps = 4/255 (1%)
Frame = +3
Query: 9 DLMHALFLVYKQDALPVFDQLLPNIMKLQEANRPWTDFQYCICFWDDMIESVGGNLSWQY 188
D++H++F YK+ LP F+QLLP I+ L RPW D Q+ +C +DD++E S++Y
Sbjct: 844 DILHSIFSSYKEKVLPWFEQLLPLIVNLICPQRPWPDRQWGLCIFDDIVEHCSP-ASFKY 902
Query: 189 CQHYLPALIAGLRHDRKEIRQAAIYGFGLMAMHGGIEFTDVLREVAPILVELVETSCSRE 368
++++ ++ + + E+RQAA YG G+MA GG + + P+LV +++ ++
Sbjct: 903 AEYFISPMLQYVCDNSPEVRQAAAYGLGVMAQFGGDNYRPFCTDALPLLVRVIQAPEAKT 962
Query: 369 EELNMSTENAISALTKICKFRPDCVPGGSLDAFLPTWLSWLPIWEDSEETPHVFGFLCDL 548
+E +TEN ISA+ KI KF+PDCV +++ LP WLSWLP+ ED EE F +LCDL
Sbjct: 963 KENVNATENCISAVGKIMKFKPDCV---NVEEVLPHWLSWLPLHEDKEEAVQTFSYLCDL 1019
Query: 549 IENSNSVL----TSNLPHVIRSIAYCIMRDGLSEENPTFRRCLNLVKMVQANGDCFATCV 716
IE+++ ++ +NLP + IA M + + E+P +R N+V+ VQ +G + C+
Sbjct: 1020 IESNHPIVLGPNNTNLPKIFSIIAEGEMHEAIKHEDPCAKRLANVVRQVQTSGGLWTECI 1079
Query: 717 NTLSKEEQAALQKAL 761
LS E+QAA+Q+ L
Sbjct: 1080 AQLSPEQQAAIQELL 1094
>sp|O74476|IMB3_SCHPO Importin beta-3 subunit
Length = 1095
Score = 123 bits (309), Expect = 6e-28
Identities = 74/239 (30%), Positives = 121/239 (50%)
Frame = +3
Query: 33 VYKQDALPVFDQLLPNIMKLQEANRPWTDFQYCICFWDDMIESVGGNLSWQYCQHYLPAL 212
++K P +++LLP + N Q+ +C DD+IE G + SW Y H+LP L
Sbjct: 857 IHKTAFCPFWERLLPYMDGFLSGNDTVAK-QWALCMMDDLIEFTGPD-SWNYKDHFLPYL 914
Query: 213 IAGLRHDRKEIRQAAIYGFGLMAMHGGIEFTDVLREVAPILVELVETSCSREEELNMSTE 392
G++ EIRQAA YG G+ A HGG + ++ P L +++E +R+EE +TE
Sbjct: 915 AEGIQSSEPEIRQAASYGIGVAAQHGGELYAEICSSALPALFKMLELPDARDEEQIYATE 974
Query: 393 NAISALTKICKFRPDCVPGGSLDAFLPTWLSWLPIWEDSEETPHVFGFLCDLIENSNSVL 572
N A+ KIC+F V LD + W++ LP+ D ++ P+ + FL +L+E ++ +
Sbjct: 975 NICVAICKICRFCSQRVQ--DLDKVVTYWINTLPVTHDEDDAPYAYTFLAELMEQNHVAV 1032
Query: 573 TSNLPHVIRSIAYCIMRDGLSEENPTFRRCLNLVKMVQANGDCFATCVNTLSKEEQAAL 749
S +P +I +A L T + V + + D + + TLS + Q AL
Sbjct: 1033 ASQMPTIITILAETFASGVLRGRTLTRLMEASKVYLARFPADQVNSVIATLSVDNQRAL 1091
>sp|P32337|IMB3_YEAST Importin beta-3 subunit (Karyopherin beta-3 subunit) (Protein
secretion enhancer 1)
Length = 1089
Score = 66.6 bits (161), Expect = 8e-11
Identities = 49/166 (29%), Positives = 78/166 (46%), Gaps = 2/166 (1%)
Frame = +3
Query: 147 DMIESVGGNLSWQYCQHYLPALIAGLRHDRKEIRQAAIYGFGLMAMHGGIEFTDVLREVA 326
D+I+ GG + ++P + L IRQAA Y G+ A + + DV
Sbjct: 885 DLIQ-YGGEQTASMKNAFIPKVTECLISPDARIRQAASYIIGVCAQYAPSTYADVCIPTL 943
Query: 327 PILVELVETSCSREEELNMSTENAISALTKICKFRPDCVPGGSLDAFLPTWLSWLPIWED 506
LV++V+ S+ EE STENA +A+ KI +P ++D + W LP D
Sbjct: 944 DTLVQIVDFPGSKLEENRSSTENASAAIAKILYAYNSNIP--NVDTYTANWFKTLPTITD 1001
Query: 507 SEETPHVFGFLCDLIENSNSVL--TSNLPHVIRSIAYCIMRDGLSE 638
E + FL LIEN++ ++ SN+ V+ S+ + L+E
Sbjct: 1002 KEAASFNYQFLSQLIENNSPIVCAQSNISAVVDSVIQALNERSLTE 1047
>sp|Q8VI75|IPO4_MOUSE Importin-4 (Importin 4a) (Imp4a) (Ran-binding protein 4) (RanBP4)
Length = 1082
Score = 54.3 bits (129), Expect = 4e-07
Identities = 53/233 (22%), Positives = 95/233 (40%)
Frame = +3
Query: 54 PVFDQLLPNIMKLQEANRPWTDFQYCICFWDDMIESVGGNLSWQYCQHYLPALIAGLRHD 233
P F LP ++ + + + + + + I+ +G S Q+ P L+ R
Sbjct: 854 PFFATFLPLLLCKTKQSCTVAEKSFAVGTLAESIQGLG-TASAQFVSRLFPVLLNNAREA 912
Query: 234 RKEIRQAAIYGFGLMAMHGGIEFTDVLREVAPILVELVETSCSREEELNMSTENAISALT 413
E+R AI+G G++A HGG D ++ +L+ L+ E + +N AL
Sbjct: 913 DPEVRSNAIFGLGVLAEHGGCPAQDHFPKLLGLLLPLL-----ARERHDRVRDNICGALA 967
Query: 414 KICKFRPDCVPGGSLDAFLPTWLSWLPIWEDSEETPHVFGFLCDLIENSNSVLTSNLPHV 593
++ P G + L T L LP+ ED EE + G L + +N ++
Sbjct: 968 RVLMASP---VGKTEPQVLATLLRALPLKEDMEEWLTI-GHLFSFLHQNNPEQVVDVASE 1023
Query: 594 IRSIAYCIMRDGLSEENPTFRRCLNLVKMVQANGDCFATCVNTLSKEEQAALQ 752
+ I I+ D + L L + + + D F T + +L ++ LQ
Sbjct: 1024 LLRICSLILPDNRIPPDTKAALLLLLTFLAKQHTDSFHTALGSLPNDKAQELQ 1076
>sp|Q8TEX9|IPO4_HUMAN Importin-4 (Importin 4b) (Imp4b) (Ran-binding protein 4) (RanBP4)
Length = 1081
Score = 50.1 bits (118), Expect = 8e-06
Identities = 51/198 (25%), Positives = 84/198 (42%)
Frame = +3
Query: 168 GNLSWQYCQHYLPALIAGLRHDRKEIRQAAIYGFGLMAMHGGIEFTDVLREVAPILVELV 347
G S Q+ LP L++ + E+R AI+G G++A HGG +E P L+ L+
Sbjct: 890 GAASAQFVSRLLPVLLSTAQEADPEVRSNAIFGMGVLAEHGG----HPAQEHFPKLLGLL 945
Query: 348 ETSCSREEELNMSTENAISALTKICKFRPDCVPGGSLDAFLPTWLSWLPIWEDSEETPHV 527
+RE + +N AL ++ P P + A L L LP+ ED EE +
Sbjct: 946 FPLLARERH-DRVRDNICGALARLLMASPTRKPEPQVLAAL---LHALPLKEDLEEWVTI 1001
Query: 528 FGFLCDLIENSNSVLTSNLPHVIRSIAYCIMRDGLSEENPTFRRCLNLVKMVQANGDCFA 707
L ++S + P ++R I I+ D + L L + + + D F
Sbjct: 1002 GRLFSFLYQSSPDQVIDVAPELLR-ICSLILADNKIPPDTKAALLLLLTFLAKQHTDSFQ 1060
Query: 708 TCVNTLSKEEQAALQKAL 761
+ +L ++ LQ L
Sbjct: 1061 AALGSLPVDKAQELQAVL 1078
>sp|P40069|IMB4_YEAST Importin beta-4 subunit (Karyopherin beta-4 subunit) (Ran-binding
protein YRB4)
Length = 1113
Score = 45.1 bits (105), Expect = 3e-04
Identities = 53/226 (23%), Positives = 94/226 (41%), Gaps = 13/226 (5%)
Frame = +3
Query: 186 YCQHYLPALIAGLRHDRK-EIRQAAIYGFGLMAMHGGIEFTDVLREVAPILVELV----- 347
+ L AL+ L D+ E+R A YG GL+ + ++ + V V L EL+
Sbjct: 900 FVHEMLEALVIRLTSDKSLEVRGNAAYGVGLLCEYASMDISAVYEPVLKALYELLSAADQ 959
Query: 348 -----ETSCSREEELNMSTENAISALTKICKFRPDCVPGGSLDAFLPTWLSWLPIWEDSE 512
E + E ++ + NA + ++ VP L+ +P L+ LP+ E
Sbjct: 960 KALAAEDDEATREIIDRAYANASGCVARMALKNSALVP---LEQTVPALLAHLPLNTGFE 1016
Query: 513 ETPHVFGFLCDLIENSNSVLTSNLPHVIRSIAYCIMRDGLSEENPTFRRCLNLVKMVQAN 692
E +F + L + ++ V+T+ P +I I ++EN + +K+ +
Sbjct: 1017 EYNPIFELIMKLYQENSPVITNETPRIIE-----IFSAVFTKEN-------DRIKLEKE- 1063
Query: 693 GDCFATCVNTLSKEE--QAALQKALERSQNNCAE*RKYLCSTYEFI 824
+TL +EE + Q E ++ E KYL +TY I
Sbjct: 1064 --------STLGREENMERLKQFQTEEMKHKVIELLKYLNTTYNGI 1101
>sp|P05527|HMIN_DROME Homeobox protein invected
Length = 576
Score = 31.6 bits (70), Expect = 3.0
Identities = 28/88 (31%), Positives = 38/88 (43%), Gaps = 2/88 (2%)
Frame = -3
Query: 520 GVSSLSSHIGSQLNHVGRNASRLP--PGTQSGRNLQILVSALMAFSVLIFSSSSREHDVS 347
G S S GS N N +R P +SG+ L + S A S L FSSS +
Sbjct: 305 GGSVSGSSTGSSKNSGNTNGNRSPLKAPKKSGKPLNLAQSNAAANSSLSFSSSLANICSN 364
Query: 346 TNSTRIGATSRKTSVNSIPPCIAIRPNP 263
+N + ATS T+ S P ++ P
Sbjct: 365 SNDSNSTATSSSTTNTSGAPVDLVKSPP 392
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 103,220,379
Number of Sequences: 369166
Number of extensions: 2145916
Number of successful extensions: 5848
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 5627
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 5835
length of database: 68,354,980
effective HSP length: 109
effective length of database: 48,218,865
effective search space used: 8582957970
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)