Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_026_A16
(858 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q64378|FKBP5_MOUSE FK506-binding protein 5 (Peptidyl-pro... 61 3e-09
sp|Q95L05|FKBP5_CERAE FK506-binding protein 5 (Peptidyl-pro... 60 6e-09
sp|Q13451|FKBP5_HUMAN FK506-binding protein 5 (Peptidyl-pro... 60 8e-09
sp|Q9XSH5|FKBP5_SAIBB FK506-binding protein 5 (Peptidyl-pro... 60 8e-09
sp|Q9XT11|FKBP5_AOTNA FK506-binding protein 5 (Peptidyl-pro... 60 1e-08
sp|Q9XSI2|FKBP5_SAGOE FK506-binding protein 5 (Peptidyl-pro... 60 1e-08
sp|P27124|FKBP4_RABIT FK506-binding protein 4 (Peptidyl-pro... 59 2e-08
sp|Q02790|FKBP4_HUMAN FK506-binding protein 4 (Peptidyl-pro... 58 4e-08
sp|Q5RF88|FKBP5_PONPY FK506-binding protein 5 (Peptidyl-pro... 58 4e-08
sp|Q07617|SPAG1_HUMAN Sperm-associated antigen 1 (Infertili... 58 4e-08
>sp|Q64378|FKBP5_MOUSE FK506-binding protein 5 (Peptidyl-prolyl cis-trans isomerase)
(PPIase) (Rotamase) (51 kDa FK506-binding protein)
(FKBP-51)
Length = 456
Score = 61.2 bits (147), Expect = 3e-09
Identities = 36/98 (36%), Positives = 47/98 (47%), Gaps = 11/98 (11%)
Frame = +2
Query: 2 ELGNEYFNAGNYDKALEMYMA---------GLNLKEISKEEK--LNCYKNQSMCYLKLSK 148
E G YF G Y +A+ Y GL+ KE E L + N +MCYLKL +
Sbjct: 273 EKGTVYFKGGKYTQAVIQYRKIVSWLEMEYGLSEKESKASESFLLAAFLNLAMCYLKLRE 332
Query: 149 FENVISSCDKALEISEMDSKSLYRRSIANLHLNKFSEA 262
+ + CDKAL + + K LYRR A L +N F A
Sbjct: 333 YNKAVECCDKALGLDSANEKGLYRRGEAQLLMNDFESA 370
>sp|Q95L05|FKBP5_CERAE FK506-binding protein 5 (Peptidyl-prolyl cis-trans isomerase) (51
kDa FK506-binding immunophilin) (FKBP-51)
Length = 457
Score = 60.5 bits (145), Expect = 6e-09
Identities = 36/98 (36%), Positives = 48/98 (48%), Gaps = 11/98 (11%)
Frame = +2
Query: 2 ELGNEYFNAGNYDKALEMYMA---------GLNLKEISKEEK--LNCYKNQSMCYLKLSK 148
E G YF G Y +A+ Y GL+ KE E L + N +MCYLKL +
Sbjct: 273 EKGTVYFKGGKYMRAVIQYGKIVSWLEMEYGLSEKESKASESFLLAAFLNLAMCYLKLRE 332
Query: 149 FENVISSCDKALEISEMDSKSLYRRSIANLHLNKFSEA 262
+ + CDKAL + + K LYRR A L +N+F A
Sbjct: 333 YTKAVECCDKALGLDSANEKGLYRRGEAQLLMNEFESA 370
>sp|Q13451|FKBP5_HUMAN FK506-binding protein 5 (Peptidyl-prolyl cis-trans isomerase)
(PPIase) (Rotamase) (51 kDa FK506-binding protein)
(FKBP-51) (54 kDa progesterone receptor-associated
immunophilin) (FKBP54) (P54) (FF1 antigen)
(HSP90-binding immunophilin) (Androgen-regulated protein
6)
Length = 457
Score = 60.1 bits (144), Expect = 8e-09
Identities = 36/98 (36%), Positives = 48/98 (48%), Gaps = 11/98 (11%)
Frame = +2
Query: 2 ELGNEYFNAGNYDKALEMYMA---------GLNLKEISKEEK--LNCYKNQSMCYLKLSK 148
E G YF G Y +A+ Y GL+ KE E L + N +MCYLKL +
Sbjct: 273 EKGTVYFKGGKYMQAVIQYGKIVSWLEMEYGLSEKESKASESFLLAAFLNLAMCYLKLRE 332
Query: 149 FENVISSCDKALEISEMDSKSLYRRSIANLHLNKFSEA 262
+ + CDKAL + + K LYRR A L +N+F A
Sbjct: 333 YTKAVECCDKALGLDSANEKGLYRRGEAQLLMNEFESA 370
>sp|Q9XSH5|FKBP5_SAIBB FK506-binding protein 5 (Peptidyl-prolyl cis-trans isomerase) (51
kDa FK506-binding immunophilin) (FKBP-51)
Length = 457
Score = 60.1 bits (144), Expect = 8e-09
Identities = 36/98 (36%), Positives = 48/98 (48%), Gaps = 11/98 (11%)
Frame = +2
Query: 2 ELGNEYFNAGNYDKALEMYMA---------GLNLKEISKEEK--LNCYKNQSMCYLKLSK 148
E G YF G Y +A+ Y GL+ KE E L + N +MCYLKL +
Sbjct: 273 EKGTVYFKGGKYVQAVIQYGKIVSWLEMEYGLSEKESKASESFLLAAFLNLAMCYLKLRE 332
Query: 149 FENVISSCDKALEISEMDSKSLYRRSIANLHLNKFSEA 262
+ + CDKAL + + K LYRR A L +N+F A
Sbjct: 333 YTKAVECCDKALGLDSANEKGLYRRGEAQLLMNEFESA 370
>sp|Q9XT11|FKBP5_AOTNA FK506-binding protein 5 (Peptidyl-prolyl cis-trans isomerase) (51
kDa FK506-binding immunophilin) (FKBP-51)
Length = 457
Score = 59.7 bits (143), Expect = 1e-08
Identities = 36/98 (36%), Positives = 48/98 (48%), Gaps = 11/98 (11%)
Frame = +2
Query: 2 ELGNEYFNAGNYDKALEMYMA---------GLNLKEISKEEK--LNCYKNQSMCYLKLSK 148
E G YF G Y +A+ Y GL+ KE E L + N +MCYLKL +
Sbjct: 273 EKGTLYFKGGKYVQAVIQYGKIVSWLEMEYGLSEKESKASESFLLAAFLNLAMCYLKLRE 332
Query: 149 FENVISSCDKALEISEMDSKSLYRRSIANLHLNKFSEA 262
+ + CDKAL + + K LYRR A L +N+F A
Sbjct: 333 YTKAVECCDKALGLDSANEKGLYRRGEAQLLMNEFESA 370
>sp|Q9XSI2|FKBP5_SAGOE FK506-binding protein 5 (Peptidyl-prolyl cis-trans isomerase) (51
kDa FK506-binding immunophilin) (FKBP-51)
Length = 457
Score = 59.7 bits (143), Expect = 1e-08
Identities = 36/98 (36%), Positives = 48/98 (48%), Gaps = 11/98 (11%)
Frame = +2
Query: 2 ELGNEYFNAGNYDKALEMYMA---------GLNLKEISKEEK--LNCYKNQSMCYLKLSK 148
E G YF G Y +A+ Y GL+ KE E L + N +MCYLKL +
Sbjct: 273 EEGTVYFKGGKYVQAVIQYGKIVSWLEMEYGLSEKESKASESFLLAAFLNLAMCYLKLRE 332
Query: 149 FENVISSCDKALEISEMDSKSLYRRSIANLHLNKFSEA 262
+ + CDKAL + + K LYRR A L +N+F A
Sbjct: 333 YAKAVECCDKALGLDSANEKGLYRRGEAQLLMNEFESA 370
>sp|P27124|FKBP4_RABIT FK506-binding protein 4 (Peptidyl-prolyl cis-trans isomerase)
(PPIase) (Rotamase) (p59 protein) (HSP binding
immunophilin) (HBI) (FKBP52 protein) (52 kDa FK506
binding protein) (FKBP59)
Length = 458
Score = 58.5 bits (140), Expect = 2e-08
Identities = 34/98 (34%), Positives = 51/98 (52%), Gaps = 11/98 (11%)
Frame = +2
Query: 2 ELGNEYFNAGNYDKALEMYM---------AGLNLKEISKEE--KLNCYKNQSMCYLKLSK 148
E G YF G Y +AL Y + + +E+ K + +L + N +MC+LKL
Sbjct: 275 ERGTVYFKEGKYKQALLQYKKIVSWLEYESSFSSEEVQKAQALRLASHLNLAMCHLKLQA 334
Query: 149 FENVISSCDKALEISEMDSKSLYRRSIANLHLNKFSEA 262
F + SC+KALE+ + K L+RR A+L +N F A
Sbjct: 335 FSAAVESCNKALELDSNNEKGLFRRGEAHLAVNDFDLA 372
>sp|Q02790|FKBP4_HUMAN FK506-binding protein 4 (Peptidyl-prolyl cis-trans isomerase)
(PPIase) (Rotamase) (p59 protein) (HSP binding
immunophilin) (HBI) (FKBP52 protein) (52 kDa FK506
binding protein) (FKBP59)
Length = 459
Score = 57.8 bits (138), Expect = 4e-08
Identities = 37/98 (37%), Positives = 50/98 (51%), Gaps = 11/98 (11%)
Frame = +2
Query: 2 ELGNEYFNAGNYDKALEMYMAGLNLKE----ISKEE-------KLNCYKNQSMCYLKLSK 148
E G YF G Y +AL Y ++ E S EE +L + N +MC+LKL
Sbjct: 275 ERGTVYFKEGKYKQALLQYKKIVSWLEYESSFSNEEAQKAQALRLASHLNLAMCHLKLQA 334
Query: 149 FENVISSCDKALEISEMDSKSLYRRSIANLHLNKFSEA 262
F I SC+KALE+ + K L+RR A+L +N F A
Sbjct: 335 FSAAIESCNKALELDSNNEKGLFRRGEAHLAVNDFELA 372
>sp|Q5RF88|FKBP5_PONPY FK506-binding protein 5 (Peptidyl-prolyl cis-trans isomerase)
(PPIase) (Rotamase)
Length = 457
Score = 57.8 bits (138), Expect = 4e-08
Identities = 35/98 (35%), Positives = 47/98 (47%), Gaps = 11/98 (11%)
Frame = +2
Query: 2 ELGNEYFNAGNYDKALEMYMA---------GLNLKEISKEEK--LNCYKNQSMCYLKLSK 148
E G YF G Y +A+ Y GL+ KE E L + N +MCY KL +
Sbjct: 273 EKGTVYFKGGKYMQAVIQYGKIVSWLEMEYGLSEKESKASESFLLAAFLNLAMCYSKLRE 332
Query: 149 FENVISSCDKALEISEMDSKSLYRRSIANLHLNKFSEA 262
+ + CDKAL + + K LYRR A L +N+F A
Sbjct: 333 YTKAVECCDKALGLDSANGKGLYRRGEAQLLMNEFESA 370
>sp|Q07617|SPAG1_HUMAN Sperm-associated antigen 1 (Infertility-related sperm protein
Spag-1) (HSD-3.8)
Length = 926
Score = 57.8 bits (138), Expect = 4e-08
Identities = 29/87 (33%), Positives = 49/87 (56%)
Frame = +2
Query: 2 ELGNEYFNAGNYDKALEMYMAGLNLKEISKEEKLNCYKNQSMCYLKLSKFENVISSCDKA 181
E GN+ N NY AL Y L + + Y N+++CYLKL +FE CD+A
Sbjct: 628 EEGNQCVNDKNYKDALSKYSECLKINNT----ECAIYTNRALCYLKLCQFEEAKQDCDQA 683
Query: 182 LEISEMDSKSLYRRSIANLHLNKFSEA 262
L++++ + K+ YRR++A+ L + ++
Sbjct: 684 LQLADGNVKAFYRRALAHKGLKNYQKS 710
Score = 54.7 bits (130), Expect = 3e-07
Identities = 29/87 (33%), Positives = 46/87 (52%)
Frame = +2
Query: 2 ELGNEYFNAGNYDKALEMYMAGLNLKEISKEEKLNCYKNQSMCYLKLSKFENVISSCDKA 181
E GNE FN+G+Y++A+ Y + IS + Y N++ +KL + + C+K
Sbjct: 214 EKGNEAFNSGDYEEAVMYYT-----RSISALPTVVAYNNRAQAEIKLQNWNSAFQDCEKV 268
Query: 182 LEISEMDSKSLYRRSIANLHLNKFSEA 262
LE+ + K+L RR+ H NK EA
Sbjct: 269 LELEPGNVKALLRRATTYKHQNKLREA 295
Score = 51.6 bits (122), Expect = 3e-06
Identities = 29/90 (32%), Positives = 46/90 (51%), Gaps = 4/90 (4%)
Frame = +2
Query: 8 GNEYFNAGNYDKALEMYMAGLNLKEISKEEKLN----CYKNQSMCYLKLSKFENVISSCD 175
GNE F +G + +A Y A + L E + E + Y N++ CYLK I C+
Sbjct: 452 GNELFRSGQFAEAAGKYSAAIALLEPAGSEIADDLSILYSNRAACYLKEGNCSGCIQDCN 511
Query: 176 KALEISEMDSKSLYRRSIANLHLNKFSEAH 265
+ALE+ K L RR++A L ++ +A+
Sbjct: 512 RALELHPFSMKPLLRRAMAYETLEQYGKAY 541
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 82,053,829
Number of Sequences: 369166
Number of extensions: 1471255
Number of successful extensions: 3567
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 3400
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 3538
length of database: 68,354,980
effective HSP length: 109
effective length of database: 48,218,865
effective search space used: 8486520240
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)