Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_025_O16
(852 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P16086|SPTA2_RAT Spectrin alpha chain, brain (Spectrin, ... 357 2e-98
sp|Q13813|SPTA2_HUMAN Spectrin alpha chain, brain (Spectrin... 356 4e-98
sp|P07751|SPTA2_CHICK Spectrin alpha chain, brain (Spectrin... 354 2e-97
sp|P13395|SPTCA_DROME Spectrin alpha chain 322 8e-88
sp|P08032|SPTA1_MOUSE Spectrin alpha chain, erythrocyte (Er... 246 6e-65
sp|P02549|SPTA1_HUMAN Spectrin alpha chain, erythrocyte (Er... 235 1e-61
sp|P16546|SPTA2_MOUSE Spectrin alpha chain, brain (Spectrin... 220 4e-57
sp|Q01082|SPTB2_HUMAN Spectrin beta chain, brain 1 (Spectri... 180 4e-45
sp|Q00963|SPTCB_DROME Spectrin beta chain 175 1e-43
sp|Q9QWN8|SPTN2_RAT Spectrin beta chain, brain 2 (Spectrin,... 154 4e-37
>sp|P16086|SPTA2_RAT Spectrin alpha chain, brain (Spectrin, non-erythroid alpha chain)
(Alpha-II spectrin) (Fodrin alpha chain)
Length = 2472
Score = 357 bits (916), Expect = 2e-98
Identities = 173/284 (60%), Positives = 215/284 (75%)
Frame = +1
Query: 1 EVESQLGSDDCGKDLNSVTNLQKKHNLLESDISSHQDRIDSFLQQADQFVHDNHFDADAI 180
EVE L SDD GKDL +V NLQKKH LLE+D+++HQDRID QA QF HFDA+ I
Sbjct: 696 EVEGHLASDDYGKDLTNVQNLQKKHALLEADVAAHQDRIDGITIQARQFQDAGHFDAENI 755
Query: 181 KKKQIEVCNRYSKLQEPLEKRKNKLNDAYKLHQFYRDADDEEDWIHEKEPIAGSTNVGRD 360
KKKQ + RY L+EP+ RK KL D+ +L Q +RD +DEE WI EKEPIA STN G+D
Sbjct: 756 KKKQEALVARYEALKEPMVARKQKLADSLRLQQLFRDVEDEETWIREKEPIAASTNRGKD 815
Query: 361 LIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANRDIEKKIDDMKNLWSDL 540
LIGVQNL+KKHQA+QAE+ GHEPRI V +G M++ H+A D++ K+ ++ W L
Sbjct: 816 LIGVQNLLKKHQALQAEIAGHEPRIKAVTQKGNAMVEEGHFAAEDVKAKLSELNQKWEAL 875
Query: 541 KNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFGKDEDSTEALLKKHDAL 720
K KA +RRQ L+DSL+AQQY ADA+EAESWMREKEP+VGST++GKDEDS EALLKKH+AL
Sbjct: 876 KAKASQRRQDLEDSLQAQQYFADANEAESWMREKEPIVGSTDYGKDEDSAEALLKKHEAL 935
Query: 721 MADIEAYRSTIDSLRTQADACKMQEAPVSDSYGKETVMALYDYQ 852
M+D+ AY S+I +LR QA +C+ Q AP+ D GKE V+ALYDYQ
Sbjct: 936 MSDLSAYGSSIQALREQAQSCRQQVAPMDDETGKELVLALYDYQ 979
Score = 220 bits (560), Expect = 4e-57
Identities = 107/256 (41%), Positives = 162/256 (63%)
Frame = +1
Query: 1 EVESQLGSDDCGKDLNSVTNLQKKHNLLESDISSHQDRIDSFLQQADQFVHDNHFDADAI 180
EVE+ L S+D GKDL SV NL KKH LLE+DIS+H+DR+ QAD + + FD +
Sbjct: 1676 EVEALLASEDYGKDLASVNNLLKKHQLLEADISAHEDRLKDLNSQADSLMTSSAFDTSQV 1735
Query: 181 KKKQIEVCNRYSKLQEPLEKRKNKLNDAYKLHQFYRDADDEEDWIHEKEPIAGSTNVGRD 360
K+K+ + R+ K++ R+ KL+++++LHQF+RD DDEE WI EK+ + S + GRD
Sbjct: 1736 KEKRDTINGRFQKIKSMATSRRAKLSESHRLHQFFRDMDDEESWIKEKKLLVSSEDYGRD 1795
Query: 361 LIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANRDIEKKIDDMKNLWSDL 540
L GVQNL KKH+ ++AE+ HEP I V + G+K+ D N +I++++ W +L
Sbjct: 1796 LTGVQNLRKKHKRLEAELAAHEPAIQGVLDTGKKLSDDNTIGQEEIQQRLAQFVEHWKEL 1855
Query: 541 KNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFGKDEDSTEALLKKHDAL 720
K A R Q L++SLE QQ++A+ E E+W+ EK LV S ++G + + LLKKH+A
Sbjct: 1856 KQLAAARGQRLEESLEYQQFVANVEEEEAWINEKMTLVASEDYGDTLAAIQGLLKKHEAF 1915
Query: 721 MADIEAYRSTIDSLRT 768
D ++ ++ + T
Sbjct: 1916 ETDFTVHKDRVNDVCT 1931
Score = 159 bits (402), Expect = 9e-39
Identities = 85/253 (33%), Positives = 141/253 (55%)
Frame = +1
Query: 22 SDDCGKDLNSVTNLQKKHNLLESDISSHQDRIDSFLQQADQFVHDNHFDADAIKKKQIEV 201
+D+ KD +++ +KH E+++S++Q RID+ + + + NH+ + + + EV
Sbjct: 597 TDEAYKDPSNLQGKVQKHQAFEAELSANQSRIDALEKAGQKLIDVNHYAKEEVAARMNEV 656
Query: 202 CNRYSKLQEPLEKRKNKLNDAYKLHQFYRDADDEEDWIHEKEPIAGSTNVGRDLIGVQNL 381
+ + KL E E + KL +A + QF R+ +D E W++E E S + G+DL VQNL
Sbjct: 657 ISLWKKLLEATELKGVKLREANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDLTNVQNL 716
Query: 382 IKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANRDIEKKIDDMKNLWSDLKNKADKR 561
KKH ++A+V H+ RI + + ++ D H+ +I+KK + + + LK R
Sbjct: 717 QKKHALLEADVAAHQDRIDGITIQARQFQDAGHFDAENIKKKQEALVARYEALKEPMVAR 776
Query: 562 RQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFGKDEDSTEALLKKHDALMADIEAY 741
+Q L DSL QQ D + E+W+REKEP+ ST GKD + LLKKH AL A+I +
Sbjct: 777 KQKLADSLRLQQLFRDVEDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGH 836
Query: 742 RSTIDSLRTQADA 780
I ++ + +A
Sbjct: 837 EPRIKAVTQKGNA 849
Score = 150 bits (379), Expect = 4e-36
Identities = 78/261 (29%), Positives = 143/261 (54%), Gaps = 4/261 (1%)
Frame = +1
Query: 16 LGSDDCGKDLNSVTNLQKKHNLLESDISSHQDRIDSFLQQADQFVHDNHFDADAIKKKQI 195
+ S+D G+DL V NL+KKH LE+++++H+ I L + DN + I+++
Sbjct: 1787 VSSEDYGRDLTGVQNLRKKHKRLEAELAAHEPAIQGVLDTGKKLSDDNTIGQEEIQQRLA 1846
Query: 196 EVCNRYSKLQEPLEKRKNKLNDAYKLHQFYRDADDEEDWIHEKEPIAGSTNVGRDLIGVQ 375
+ + +L++ R +L ++ + QF + ++EE WI+EK + S + G L +Q
Sbjct: 1847 QFVEHWKELKQLAAARGQRLEESLEYQQFVANVEEEEAWINEKMTLVASEDYGDTLAAIQ 1906
Query: 376 NLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANRDIEKKIDDMKNLWSDLKNKAD 555
L+KKH+A + + T H+ R+ +VC GQ +I N++ +I K+ + SDL+ A
Sbjct: 1907 GLLKKHEAFETDFTVHKDRVNDVCTNGQDLIKKNNHHEENISSKMKGLNGKVSDLEKAAA 1966
Query: 556 KRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFGKDEDSTEALLKKHDALMADIE 735
+R+ LD++ Q+ A ESW+ EKE + + ++G+D S + LL K + A ++
Sbjct: 1967 QRKAKLDENSAFLQFNWKADVVESWIGEKENSLKTDDYGRDLSSVQTLLTKQETFDAGLQ 2026
Query: 736 AYR----STIDSLRTQADACK 786
A++ + I +L+ Q A K
Sbjct: 2027 AFQQEGIANITALKDQLLAAK 2047
Score = 149 bits (375), Expect = 1e-35
Identities = 76/251 (30%), Positives = 139/251 (55%)
Frame = +1
Query: 7 ESQLGSDDCGKDLNSVTNLQKKHNLLESDISSHQDRIDSFLQQADQFVHDNHFDADAIKK 186
E+ + S++ G+DL V LQKK ++D+++H++R++ Q A + + + H + + IK
Sbjct: 169 EAIVTSEELGQDLEHVEVLQKKFEEFQTDLAAHEERVNEVNQFAAKLIQEQHPEEELIKT 228
Query: 187 KQIEVCNRYSKLQEPLEKRKNKLNDAYKLHQFYRDADDEEDWIHEKEPIAGSTNVGRDLI 366
KQ EV + +L+ +R+ KL A ++ +F RD D+ WI EKE + S + GRDL
Sbjct: 229 KQEEVNAAWQRLKGLALQRQGKLFGAAEVQRFNRDVDETIGWIKEKEQLMASDDFGRDLA 288
Query: 367 GVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANRDIEKKIDDMKNLWSDLKN 546
VQ L++KH+ ++ ++ E ++ +C E ++ + + I+ K +++ W ++
Sbjct: 289 SVQALLRKHEGLERDLAALEDKVKALCAEADRLQQSHPLSANQIQVKREELITNWEQIRT 348
Query: 547 KADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFGKDEDSTEALLKKHDALMA 726
A +R LDDS Q++LAD + SW+ E + L+ + E D EALL +H
Sbjct: 349 LAAERHARLDDSYRLQRFLADFRDLTSWVTEMKALINADELANDVAGAEALLDRHQEHKG 408
Query: 727 DIEAYRSTIDS 759
+I+A+ + S
Sbjct: 409 EIDAHEDSFKS 419
Score = 146 bits (368), Expect = 8e-35
Identities = 82/265 (30%), Positives = 143/265 (53%)
Frame = +1
Query: 13 QLGSDDCGKDLNSVTNLQKKHNLLESDISSHQDRIDSFLQQADQFVHDNHFDADAIKKKQ 192
Q+ SD+ KD ++ +KH E+++ ++ I + + + + HF ++ I+ +
Sbjct: 65 QVASDENYKDPTNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETIRTRL 124
Query: 193 IEVCNRYSKLQEPLEKRKNKLNDAYKLHQFYRDADDEEDWIHEKEPIAGSTNVGRDLIGV 372
+E+ ++ L E + ++ KL A KL Q+ R+ +D DWI++KE I S +G+DL V
Sbjct: 125 MELHRQWELLLEKMREKGIKLLQAQKLVQYLRECEDVMDWINDKEAIVTSEELGQDLEHV 184
Query: 373 QNLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANRDIEKKIDDMKNLWSDLKNKA 552
+ L KK + Q ++ HE R+ EV K+I H I+ K +++ W LK A
Sbjct: 185 EVLQKKFEEFQTDLAAHEERVNEVNQFAAKLIQEQHPEEELIKTKQEEVNAAWQRLKGLA 244
Query: 553 DKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFGKDEDSTEALLKKHDALMADI 732
+R+ L + E Q++ D E W++EKE L+ S +FG+D S +ALL+KH+ L D+
Sbjct: 245 LQRQGKLFGAAEVQRFNRDVDETIGWIKEKEQLMASDDFGRDLASVQALLRKHEGLERDL 304
Query: 733 EAYRSTIDSLRTQADACKMQEAPVS 807
A + +L +AD + Q P+S
Sbjct: 305 AALEDKVKALCAEADRLQ-QSHPLS 328
Score = 138 bits (347), Expect = 2e-32
Identities = 77/259 (29%), Positives = 137/259 (52%)
Frame = +1
Query: 1 EVESQLGSDDCGKDLNSVTNLQKKHNLLESDISSHQDRIDSFLQQADQFVHDNHFDADAI 180
E L +D+ G DL SV LQ+KH E D+++ D+++S + A + + + A+ +
Sbjct: 1251 EKNQALNTDNYGHDLASVQALQRKHEGFERDLAALGDKVNSLGETAQRLIQSHPESAEDL 1310
Query: 181 KKKQIEVCNRYSKLQEPLEKRKNKLNDAYKLHQFYRDADDEEDWIHEKEPIAGSTNVGRD 360
K+K E+ ++ L + ++RK KL D++ L +F D D WI+ + S + +D
Sbjct: 1311 KEKCTELNQAWTSLGKRADQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGLVSSDELAKD 1370
Query: 361 LIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANRDIEKKIDDMKNLWSDL 540
+ G + L+++HQ + E+ GQ+++ HYA+ +I++K+D + +DL
Sbjct: 1371 VTGAEALLERHQEHRTEIDARAGTFQAFEQFGQQLLAHGHYASPEIKEKLDILDQERTDL 1430
Query: 541 KNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFGKDEDSTEALLKKHDAL 720
+ +RR +LD LE Q + D +AE+WM +E + + + G DS EAL+KKH+
Sbjct: 1431 EKAWVQRRMMLDHCLELQLFHRDCEQAENWMAAREAFLNTEDKGDSLDSVEALIKKHEDF 1490
Query: 721 MADIEAYRSTIDSLRTQAD 777
I I +L+ AD
Sbjct: 1491 DKAINVQEEKIAALQAFAD 1509
Score = 137 bits (345), Expect = 4e-32
Identities = 69/254 (27%), Positives = 132/254 (51%)
Frame = +1
Query: 1 EVESQLGSDDCGKDLNSVTNLQKKHNLLESDISSHQDRIDSFLQQADQFVHDNHFDADAI 180
E E + SDD G+DL SV L +KH LE D+++ +D++ + +AD+ + A+ I
Sbjct: 273 EKEQLMASDDFGRDLASVQALLRKHEGLERDLAALEDKVKALCAEADRLQQSHPLSANQI 332
Query: 181 KKKQIEVCNRYSKLQEPLEKRKNKLNDAYKLHQFYRDADDEEDWIHEKEPIAGSTNVGRD 360
+ K+ E+ + +++ +R +L+D+Y+L +F D D W+ E + + + + D
Sbjct: 333 QVKREELITNWEQIRTLAAERHARLDDSYRLQRFLADFRDLTSWVTEMKALINADELAND 392
Query: 361 LIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANRDIEKKIDDMKNLWSDL 540
+ G + L+ +HQ + E+ HE GQ ++ HYA+ ++ +K+ + + L
Sbjct: 393 VAGAEALLDRHQEHKGEIDAHEDSFKSADESGQALLAAGHYASDEVREKLSILSEERAAL 452
Query: 541 KNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFGKDEDSTEALLKKHDAL 720
+ RRQ + ++ Q + D + ++WM ++E + + + G DS EALLKKH+
Sbjct: 453 LELWELRRQQYEQCMDLQLFYRDTEQVDNWMSKQEAFLLNEDLGDSLDSVEALLKKHEDF 512
Query: 721 MADIEAYRSTIDSL 762
+ A I +L
Sbjct: 513 EKSLSAQEEKITAL 526
Score = 134 bits (338), Expect = 2e-31
Identities = 80/266 (30%), Positives = 142/266 (53%), Gaps = 2/266 (0%)
Frame = +1
Query: 7 ESQLGSDDCGKDLNSVTNLQKKHNLLESDISSHQDRIDSFLQQADQFVHDNHFDADAIKK 186
E+ L ++D G L+SV L KKH + I+ +++I + ADQ + +H+ I
Sbjct: 1465 EAFLNTEDKGDSLDSVEALIKKHEDFDKAINVQEEKIAALQAFADQLIAVDHYAKGDIAN 1524
Query: 187 KQIEVCNRYSKLQEPLEKRKNKLNDAYKLHQFYRDADDEEDWIHEKEPIAGSTNVGRDLI 366
++ EV +R+ +L+ + ++++KL ++ L QF RD D+ E WI EK A + +D
Sbjct: 1525 RRNEVLDRWRRLKAQMIEKRSKLGESQTLQQFSRDVDEIEAWISEKLQTASDESY-KDPT 1583
Query: 367 GVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANRD--IEKKIDDMKNLWSDL 540
+Q+ +KHQA +AE+ + RI V + G +I+ A + ++ ++ + + W L
Sbjct: 1584 NIQSKHQKHQAFEAELHANADRIRGVIDMGNSLIERGACAGSEDAVKARLAALADQWQFL 1643
Query: 541 KNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFGKDEDSTEALLKKHDAL 720
K+ ++ Q L ++ + Q + + + W+ E E L+ S ++GKD S LLKKH L
Sbjct: 1644 VQKSAEKSQKLKEANKQQNFNTGIKDFDFWLSEVEALLASEDYGKDLASVNNLLKKHQLL 1703
Query: 721 MADIEAYRSTIDSLRTQADACKMQEA 798
ADI A+ + L +QAD+ A
Sbjct: 1704 EADISAHEDRLKDLNSQADSLMTSSA 1729
Score = 133 bits (335), Expect = 5e-31
Identities = 67/252 (26%), Positives = 131/252 (51%), Gaps = 2/252 (0%)
Frame = +1
Query: 13 QLGSDDCGKDLNSVTNLQKKHNLLESDISSHQDRIDSFLQQADQFVHDNHF--DADAIKK 186
Q SD+ KD ++ + +KH E+++ ++ DRI + + + DA+K
Sbjct: 1572 QTASDESYKDPTNIQSKHQKHQAFEAELHANADRIRGVIDMGNSLIERGACAGSEDAVKA 1631
Query: 187 KQIEVCNRYSKLQEPLEKRKNKLNDAYKLHQFYRDADDEEDWIHEKEPIAGSTNVGRDLI 366
+ + +++ L + ++ KL +A K F D + W+ E E + S + G+DL
Sbjct: 1632 RLAALADQWQFLVQKSAEKSQKLKEANKQQNFNTGIKDFDFWLSEVEALLASEDYGKDLA 1691
Query: 367 GVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANRDIEKKIDDMKNLWSDLKN 546
V NL+KKHQ ++A+++ HE R+ ++ ++ ++ + + +++K D + + +K+
Sbjct: 1692 SVNNLLKKHQLLEADISAHEDRLKDLNSQADSLMTSSAFDTSQVKEKRDTINGRFQKIKS 1751
Query: 547 KADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFGKDEDSTEALLKKHDALMA 726
A RR L +S Q+ D + ESW++EK+ LV S ++G+D + L KKH L A
Sbjct: 1752 MATSRRAKLSESHRLHQFFRDMDDEESWIKEKKLLVSSEDYGRDLTGVQNLRKKHKRLEA 1811
Query: 727 DIEAYRSTIDSL 762
++ A+ I +
Sbjct: 1812 ELAAHEPAIQGV 1823
Score = 125 bits (313), Expect = 2e-28
Identities = 73/289 (25%), Positives = 138/289 (47%), Gaps = 36/289 (12%)
Frame = +1
Query: 1 EVESQLGSDDCGKDLNSVTNLQKKHNLLESDISSHQDRIDSFLQQADQFVHDNHF--DAD 174
E E+ L S++ G DL V LQKK + + D+ +++ R+ + A+ + +
Sbjct: 1109 EKEAALTSEEVGADLEQVEVLQKKFDDFQKDLKANESRLKDINKVAEDLESEGLMAEEVQ 1168
Query: 175 AIKKKQI----------------------------------EVCNRYSKLQEPLEKRKNK 252
A++++++ E+ R+ LQ+ E+R
Sbjct: 1169 AVQQQEVYGMMPRDEADSKTASPWKSARLMVHTVATFNSIKELNERWRSLQQLAEERSQL 1228
Query: 253 LNDAYKLHQFYRDADDEEDWIHEKEPIAGSTNVGRDLIGVQNLIKKHQAIQAEVTGHEPR 432
L A+++ +F+RDAD+ ++WI EK + N G DL VQ L +KH+ + ++ +
Sbjct: 1229 LGSAHEVQRFHRDADETKEWIEEKNQALNTDNYGHDLASVQALQRKHEGFERDLAALGDK 1288
Query: 433 ILEVCNEGQKMIDGNHYANRDIEKKIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYLADA 612
+ + Q++I + + D+++K ++ W+ L +AD+R+ L DS + Q++L+D
Sbjct: 1289 VNSLGETAQRLIQSHPESAEDLKEKCTELNQAWTSLGKRADQRKAKLGDSHDLQRFLSDF 1348
Query: 613 SEAESWMREKEPLVGSTEFGKDEDSTEALLKKHDALMADIEAYRSTIDS 759
+ SW+ LV S E KD EALL++H +I+A T +
Sbjct: 1349 RDLMSWINGIRGLVSSDELAKDVTGAEALLERHQEHRTEIDARAGTFQA 1397
Score = 121 bits (304), Expect = 2e-27
Identities = 73/279 (26%), Positives = 135/279 (48%)
Frame = +1
Query: 1 EVESQLGSDDCGKDLNSVTNLQKKHNLLESDISSHQDRIDSFLQQADQFVHDNHFDADAI 180
E+++ + +D+ D+ L +H + +I +H+D S + + H+ +D +
Sbjct: 379 EMKALINADELANDVAGAEALLDRHQEHKGEIDAHEDSFKSADESGQALLAAGHYASDEV 438
Query: 181 KKKQIEVCNRYSKLQEPLEKRKNKLNDAYKLHQFYRDADDEEDWIHEKEPIAGSTNVGRD 360
++K + + L E E R+ + L FYRD + ++W+ ++E + ++G
Sbjct: 439 REKLSILSEERAALLELWELRRQQYEQCMDLQLFYRDTEQVDNWMSKQEAFLLNEDLGDS 498
Query: 361 LIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANRDIEKKIDDMKNLWSDL 540
L V+ L+KKH+ + ++ E +I + K+I NHYA D+ + D + + + L
Sbjct: 499 LDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNHYAMEDVATRRDALLSRRNAL 558
Query: 541 KNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFGKDEDSTEALLKKHDAL 720
+A RR L DS QQ+ D+ E +SW+ EK + E KD + + ++KH A
Sbjct: 559 HERAMHRRAQLADSFHLQQFFRDSDELKSWVNEKMK-TATDEAYKDPSNLQGKVQKHQAF 617
Query: 721 MADIEAYRSTIDSLRTQADACKMQEAPVSDSYGKETVMA 837
A++ A +S ID+L Q+ + Y KE V A
Sbjct: 618 EAELSANQSRIDALEKAG-----QKLIDVNHYAKEEVAA 651
Score = 113 bits (283), Expect = 6e-25
Identities = 61/211 (28%), Positives = 110/211 (52%)
Frame = +1
Query: 169 ADAIKKKQIEVCNRYSKLQEPLEKRKNKLNDAYKLHQFYRDADDEEDWIHEKEPIAGSTN 348
A+ I++++ +V +RY + +E R+ KL D+Y+ F RDA++ E WI EK +A N
Sbjct: 12 AEDIQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDAEELEKWIQEKLQVASDEN 71
Query: 349 VGRDLIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANRDIEKKIDDMKNL 528
+D +Q ++KHQA +AEV + I+++ G MI H+A+ I ++ ++
Sbjct: 72 Y-KDPTNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETIRTRLMELHRQ 130
Query: 529 WSDLKNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFGKDEDSTEALLKK 708
W L K ++ L + + QYL + + W+ +KE +V S E G+D + E L KK
Sbjct: 131 WELLLEKMREKGIKLLQAQKLVQYLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQKK 190
Query: 709 HDALMADIEAYRSTIDSLRTQADACKMQEAP 801
+ D+ A+ ++ + A ++ P
Sbjct: 191 FEEFQTDLAAHEERVNEVNQFAAKLIQEQHP 221
Score = 105 bits (261), Expect = 2e-22
Identities = 63/245 (25%), Positives = 118/245 (48%)
Frame = +1
Query: 4 VESQLGSDDCGKDLNSVTNLQKKHNLLESDISSHQDRIDSFLQQADQFVHDNHFDADAIK 183
+ + SD+ KD+ L ++H ++I + +F Q Q + H+ + IK
Sbjct: 1358 IRGLVSSDELAKDVTGAEALLERHQEHRTEIDARAGTFQAFEQFGQQLLAHGHYASPEIK 1417
Query: 184 KKQIEVCNRYSKLQEPLEKRKNKLNDAYKLHQFYRDADDEEDWIHEKEPIAGSTNVGRDL 363
+K + + L++ +R+ L+ +L F+RD + E+W+ +E + + G L
Sbjct: 1418 EKLDILDQERTDLEKAWVQRRMMLDHCLELQLFHRDCEQAENWMAAREAFLNTEDKGDSL 1477
Query: 364 IGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANRDIEKKIDDMKNLWSDLK 543
V+ LIKKH+ + E +I + ++I +HYA DI + +++ + W LK
Sbjct: 1478 DSVEALIKKHEDFDKAINVQEEKIAALQAFADQLIAVDHYAKGDIANRRNEVLDRWRRLK 1537
Query: 544 NKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFGKDEDSTEALLKKHDALM 723
+ ++R L +S QQ+ D E E+W+ EK S E KD + ++ +KH A
Sbjct: 1538 AQMIEKRSKLGESQTLQQFSRDVDEIEAWISEKLQ-TASDESYKDPTNIQSKHQKHQAFE 1596
Query: 724 ADIEA 738
A++ A
Sbjct: 1597 AELHA 1601
Score = 87.4 bits (215), Expect = 4e-17
Identities = 68/270 (25%), Positives = 117/270 (43%), Gaps = 39/270 (14%)
Frame = +1
Query: 70 KHNLLESD--ISSHQDRIDSFLQQADQFVHDNHFDADAIKKKQIEVCNRYSKLQEPLEKR 243
+ NLLE I+ Q +ID+ Q + +++ KQ+E Y L E EKR
Sbjct: 1032 RENLLEEQGSIALRQGQIDN------QTRITKEAGSVSLRMKQVE--ELYQSLLELGEKR 1083
Query: 244 KNKLNDAYKLHQFYRDADDEEDWIHEKEPIAGSTNVGRDLIGVQNLIKKHQAIQAEVTGH 423
K L + K +R+A++ + WI+EKE S VG DL V+ L KK Q ++ +
Sbjct: 1084 KGMLEKSCKKFMLFREANELQQWINEKEAALTSEEVGADLEQVEVLQKKFDDFQKDLKAN 1143
Query: 424 EPRILEVCNEGQKMIDGNHYANRDIE---------------------------------- 501
E R+ ++ N+ + ++ +++
Sbjct: 1144 ESRLKDI-NKVAEDLESEGLMAEEVQAVQQQEVYGMMPRDEADSKTASPWKSARLMVHTV 1202
Query: 502 ---KKIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFG 672
I ++ W L+ A++R QLL + E Q++ DA E + W+ EK + + +G
Sbjct: 1203 ATFNSIKELNERWRSLQQLAEERSQLLGSAHEVQRFHRDADETKEWIEEKNQALNTDNYG 1262
Query: 673 KDEDSTEALLKKHDALMADIEAYRSTIDSL 762
D S +AL +KH+ D+ A ++SL
Sbjct: 1263 HDLASVQALQRKHEGFERDLAALGDKVNSL 1292
Score = 64.7 bits (156), Expect = 3e-10
Identities = 59/271 (21%), Positives = 111/271 (40%), Gaps = 12/271 (4%)
Frame = +1
Query: 1 EVESQLGSDDCGKDLNSVTNLQKKHNLLESDISSHQDRIDSFLQQADQFVHD-NHFDADA 177
E E +GS D GKD +S L KKH L SD+S++ I + +QA D +
Sbjct: 908 EKEPIVGSTDYGKDEDSAEALLKKHEALMSDLSAYGSSIQALREQAQSCRQQVAPMDDET 967
Query: 178 IKKKQIEVCNRYSKLQEPLEKRKNKL--------NDAYKLHQFYRDADDEEDWIHEKEPI 333
K+ + + + K + +K + D +K+ R ++ + +P
Sbjct: 968 GKELVLALYDYQEKSpreVTMKKGDILTLLNSTNKDWWKVEVNDRQGFVPAAYVKKLDPA 1027
Query: 334 AGSTNVGRDLIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANRD---IEK 504
++ +NL+++ +I Q ID ++ +
Sbjct: 1028 QSASR--------ENLLEEQGSIALR---------------QGQIDNQTRITKEAGSVSL 1064
Query: 505 KIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFGKDED 684
++ ++ L+ L +KR+ +L+ S + +A+E + W+ EKE + S E G D +
Sbjct: 1065 RMKQVEELYQSLLELGEKRKGMLEKSCKKFMLFREANELQQWINEKEAALTSEEVGADLE 1124
Query: 685 STEALLKKHDALMADIEAYRSTIDSLRTQAD 777
E L KK D D++A S + + A+
Sbjct: 1125 QVEVLQKKFDDFQKDLKANESRLKDINKVAE 1155
Score = 58.9 bits (141), Expect = 2e-08
Identities = 68/294 (23%), Positives = 123/294 (41%), Gaps = 23/294 (7%)
Frame = +1
Query: 1 EVESQLGSDDCGKDLNSVTNLQKKHNLLESDISS-HQDRIDSFLQQADQFVHDNHFDADA 177
E E+ L +DD G+DL+SV L K ++ + + Q+ I + DQ + H + A
Sbjct: 1994 EKENSLKTDDYGRDLSSVQTLLTKQETFDAGLQAFQQEGIANITALKDQLLAAKHIQSKA 2053
Query: 178 IKKKQIEVCNRYSKLQEPLEKRKNKLNDAYKLHQ--------FYRDADDEEDWIHEKEPI 333
I+ + + R+++L RK KL +A + F + A W E
Sbjct: 2054 IEARHASLMKRWTQLLANSATRKKKLLEAQSHFRKVEDLFLTFAKKASAFNSWFENAEED 2113
Query: 334 AGSTNVGRDLIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKM----IDGNHYANRDIE 501
L ++ L + H A ++ ++ + ++ +++ + N Y +E
Sbjct: 2114 LTDPVRCNSLEEIKALREAHDAFRSSLSSAQADFNQLAELDRQIKSFRVASNPYTWFTME 2173
Query: 502 KKIDDMKNLWSDLKNK-----ADKRRQLLDDSLEAQQYLADASEAESWMREKEP--LVGS 660
+ +NL +K + ++RRQ +D L Q++ A+ W++E L GS
Sbjct: 2174 ALEETWRNLQKIIKERELELQKEQRRQEENDKLR-QEFAQHANAFHQWIQETRTYLLDGS 2232
Query: 661 ---TEFGKDEDSTEALLKKHDALMADIEAYRSTIDSLRTQADACKMQEAPVSDS 813
E G E EA +KH +I A RS + + A M+EA + D+
Sbjct: 2233 CMVEESGTLESQLEATKRKHQ----EIRAMRSQLKKIEDLGAA--MEEALILDN 2280
>sp|Q13813|SPTA2_HUMAN Spectrin alpha chain, brain (Spectrin, non-erythroid alpha chain)
(Alpha-II spectrin) (Fodrin alpha chain)
Length = 2472
Score = 356 bits (914), Expect = 4e-98
Identities = 173/284 (60%), Positives = 214/284 (75%)
Frame = +1
Query: 1 EVESQLGSDDCGKDLNSVTNLQKKHNLLESDISSHQDRIDSFLQQADQFVHDNHFDADAI 180
EVE L SDD GKDL +V NLQKKH LLE+D+++HQDRID QA QF HFDA+ I
Sbjct: 696 EVEGHLASDDYGKDLTNVQNLQKKHALLEADVAAHQDRIDGITIQARQFQDAGHFDAENI 755
Query: 181 KKKQIEVCNRYSKLQEPLEKRKNKLNDAYKLHQFYRDADDEEDWIHEKEPIAGSTNVGRD 360
KKKQ + RY L+EP+ RK KL D+ +L Q +RD +DEE WI EKEPIA STN G+D
Sbjct: 756 KKKQEALVARYEALKEPMVARKQKLADSLRLQQLFRDVEDEETWIREKEPIAASTNRGKD 815
Query: 361 LIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANRDIEKKIDDMKNLWSDL 540
LIGVQNL+KKHQA+QAE+ GHEPRI V +G M++ H+A D++ K+ ++ W L
Sbjct: 816 LIGVQNLLKKHQALQAEIAGHEPRIKAVTQKGNAMVEEGHFAAEDVKAKLHELNQKWEAL 875
Query: 541 KNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFGKDEDSTEALLKKHDAL 720
K KA +RRQ L+DSL+AQQY ADA+EAESWMREKEP+VGST++GKDEDS EALLKKH+AL
Sbjct: 876 KAKASQRRQDLEDSLQAQQYFADANEAESWMREKEPIVGSTDYGKDEDSAEALLKKHEAL 935
Query: 721 MADIEAYRSTIDSLRTQADACKMQEAPVSDSYGKETVMALYDYQ 852
M+D+ AY S+I +LR QA +C+ Q AP D GKE V+ALYDYQ
Sbjct: 936 MSDLSAYGSSIQALREQAQSCRQQVAPTDDETGKELVLALYDYQ 979
Score = 223 bits (569), Expect = 4e-58
Identities = 109/256 (42%), Positives = 162/256 (63%)
Frame = +1
Query: 1 EVESQLGSDDCGKDLNSVTNLQKKHNLLESDISSHQDRIDSFLQQADQFVHDNHFDADAI 180
EVE+ L S+D GKDL SV NL KKH LLE+DIS+H+DR+ QAD + + FD +
Sbjct: 1676 EVEALLASEDYGKDLASVNNLLKKHQLLEADISAHEDRLKDLNSQADSLMTSSAFDTSQV 1735
Query: 181 KKKQIEVCNRYSKLQEPLEKRKNKLNDAYKLHQFYRDADDEEDWIHEKEPIAGSTNVGRD 360
K K+ + R+ K++ R+ KLN++++LHQF+RD DDEE WI EK+ + GS + GRD
Sbjct: 1736 KDKRDTINGRFQKIKSMAASRRAKLNESHRLHQFFRDMDDEESWIKEKKLLVGSEDYGRD 1795
Query: 361 LIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANRDIEKKIDDMKNLWSDL 540
L GVQNL KKH+ ++AE+ HEP I V + G+K+ D N +I++++ W +L
Sbjct: 1796 LTGVQNLRKKHKRLEAELAAHEPAIQGVLDTGKKLSDDNTIGKEEIQQRLAQFVEHWKEL 1855
Query: 541 KNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFGKDEDSTEALLKKHDAL 720
K A R Q L++SLE QQ++A+ E E+W+ EK LV S ++G + + LLKKH+A
Sbjct: 1856 KQLAAARGQRLEESLEYQQFVANVEEEEAWINEKMTLVASEDYGDTLAAIQGLLKKHEAF 1915
Query: 721 MADIEAYRSTIDSLRT 768
D ++ ++ + T
Sbjct: 1916 ETDFTVHKDRVNDVCT 1931
Score = 160 bits (406), Expect = 3e-39
Identities = 86/253 (33%), Positives = 141/253 (55%)
Frame = +1
Query: 22 SDDCGKDLNSVTNLQKKHNLLESDISSHQDRIDSFLQQADQFVHDNHFDADAIKKKQIEV 201
+D+ KD +++ +KH E+++S++Q RID+ + + + NH+ D + + EV
Sbjct: 597 TDEAYKDPSNLQGKVQKHQAFEAELSANQSRIDALEKAGQKLIDVNHYAKDEVAARMNEV 656
Query: 202 CNRYSKLQEPLEKRKNKLNDAYKLHQFYRDADDEEDWIHEKEPIAGSTNVGRDLIGVQNL 381
+ + KL E E + KL +A + QF R+ +D E W++E E S + G+DL VQNL
Sbjct: 657 ISLWKKLLEATELKGIKLREANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDLTNVQNL 716
Query: 382 IKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANRDIEKKIDDMKNLWSDLKNKADKR 561
KKH ++A+V H+ RI + + ++ D H+ +I+KK + + + LK R
Sbjct: 717 QKKHALLEADVAAHQDRIDGITIQARQFQDAGHFDAENIKKKQEALVARYEALKEPMVAR 776
Query: 562 RQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFGKDEDSTEALLKKHDALMADIEAY 741
+Q L DSL QQ D + E+W+REKEP+ ST GKD + LLKKH AL A+I +
Sbjct: 777 KQKLADSLRLQQLFRDVEDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGH 836
Query: 742 RSTIDSLRTQADA 780
I ++ + +A
Sbjct: 837 EPRIKAVTQKGNA 849
Score = 152 bits (385), Expect = 9e-37
Identities = 79/261 (30%), Positives = 144/261 (55%), Gaps = 4/261 (1%)
Frame = +1
Query: 16 LGSDDCGKDLNSVTNLQKKHNLLESDISSHQDRIDSFLQQADQFVHDNHFDADAIKKKQI 195
+GS+D G+DL V NL+KKH LE+++++H+ I L + DN + I+++
Sbjct: 1787 VGSEDYGRDLTGVQNLRKKHKRLEAELAAHEPAIQGVLDTGKKLSDDNTIGKEEIQQRLA 1846
Query: 196 EVCNRYSKLQEPLEKRKNKLNDAYKLHQFYRDADDEEDWIHEKEPIAGSTNVGRDLIGVQ 375
+ + +L++ R +L ++ + QF + ++EE WI+EK + S + G L +Q
Sbjct: 1847 QFVEHWKELKQLAAARGQRLEESLEYQQFVANVEEEEAWINEKMTLVASEDYGDTLAAIQ 1906
Query: 376 NLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANRDIEKKIDDMKNLWSDLKNKAD 555
L+KKH+A + + T H+ R+ +VC GQ +I N++ +I K+ + SDL+ A
Sbjct: 1907 GLLKKHEAFETDFTVHKDRVNDVCTNGQDLIKKNNHHEENISSKMKGLNGKVSDLEKAAA 1966
Query: 556 KRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFGKDEDSTEALLKKHDALMADIE 735
+R+ LD++ Q+ A ESW+ EKE + + ++G+D S + LL K + A ++
Sbjct: 1967 QRKAKLDENSAFLQFNWKADVVESWIGEKENSLKTDDYGRDLSSVQTLLTKQETFDAGLQ 2026
Query: 736 AYR----STIDSLRTQADACK 786
A++ + I +L+ Q A K
Sbjct: 2027 AFQQEGIANITALKDQLLAAK 2047
Score = 149 bits (377), Expect = 7e-36
Identities = 84/265 (31%), Positives = 144/265 (54%)
Frame = +1
Query: 13 QLGSDDCGKDLNSVTNLQKKHNLLESDISSHQDRIDSFLQQADQFVHDNHFDADAIKKKQ 192
Q+ SD+ KD ++ +KH E+++ ++ I + + + + HF ++ I+ +
Sbjct: 65 QIASDENYKDPTNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETIRTRL 124
Query: 193 IEVCNRYSKLQEPLEKRKNKLNDAYKLHQFYRDADDEEDWIHEKEPIAGSTNVGRDLIGV 372
+E+ ++ L E + ++ KL A KL Q+ R+ +D DWI++KE I S +G+DL V
Sbjct: 125 MELHRQWELLLEKMREKGIKLLQAQKLVQYLRECEDVMDWINDKEAIVTSEELGQDLEHV 184
Query: 373 QNLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANRDIEKKIDDMKNLWSDLKNKA 552
+ L KK + Q ++ HE R+ EV K+I H I+ K D++ W LK A
Sbjct: 185 EVLQKKFEEFQTDMAAHEERVNEVNQFAAKLIQEQHPEEELIKTKQDEVNAAWQRLKGLA 244
Query: 553 DKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFGKDEDSTEALLKKHDALMADI 732
+R+ L + E Q++ D E SW++EKE L+ S +FG+D S +ALL+KH+ L D+
Sbjct: 245 LQRQGKLFGAAEVQRFNRDVDETISWIKEKEQLMASDDFGRDLASVQALLRKHEGLERDL 304
Query: 733 EAYRSTIDSLRTQADACKMQEAPVS 807
A + +L +AD + Q P+S
Sbjct: 305 AALEDKVKALCAEADRLQ-QSHPLS 328
Score = 146 bits (369), Expect = 6e-35
Identities = 75/251 (29%), Positives = 139/251 (55%)
Frame = +1
Query: 7 ESQLGSDDCGKDLNSVTNLQKKHNLLESDISSHQDRIDSFLQQADQFVHDNHFDADAIKK 186
E+ + S++ G+DL V LQKK ++D+++H++R++ Q A + + + H + + IK
Sbjct: 169 EAIVTSEELGQDLEHVEVLQKKFEEFQTDMAAHEERVNEVNQFAAKLIQEQHPEEELIKT 228
Query: 187 KQIEVCNRYSKLQEPLEKRKNKLNDAYKLHQFYRDADDEEDWIHEKEPIAGSTNVGRDLI 366
KQ EV + +L+ +R+ KL A ++ +F RD D+ WI EKE + S + GRDL
Sbjct: 229 KQDEVNAAWQRLKGLALQRQGKLFGAAEVQRFNRDVDETISWIKEKEQLMASDDFGRDLA 288
Query: 367 GVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANRDIEKKIDDMKNLWSDLKN 546
VQ L++KH+ ++ ++ E ++ +C E ++ + + I+ K +++ W ++
Sbjct: 289 SVQALLRKHEGLERDLAALEDKVKALCAEADRLQQSHPLSATQIQVKREELITNWEQIRT 348
Query: 547 KADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFGKDEDSTEALLKKHDALMA 726
A +R L+DS Q++LAD + SW+ E + L+ + E D EALL +H
Sbjct: 349 LAAERHARLNDSYRLQRFLADFRDLTSWVTEMKALINADELASDVAGAEALLDRHQEHKG 408
Query: 727 DIEAYRSTIDS 759
+I+A+ + S
Sbjct: 409 EIDAHEDSFKS 419
Score = 137 bits (346), Expect = 3e-32
Identities = 70/254 (27%), Positives = 131/254 (51%)
Frame = +1
Query: 1 EVESQLGSDDCGKDLNSVTNLQKKHNLLESDISSHQDRIDSFLQQADQFVHDNHFDADAI 180
E E + SDD G+DL SV L +KH LE D+++ +D++ + +AD+ + A I
Sbjct: 273 EKEQLMASDDFGRDLASVQALLRKHEGLERDLAALEDKVKALCAEADRLQQSHPLSATQI 332
Query: 181 KKKQIEVCNRYSKLQEPLEKRKNKLNDAYKLHQFYRDADDEEDWIHEKEPIAGSTNVGRD 360
+ K+ E+ + +++ +R +LND+Y+L +F D D W+ E + + + + D
Sbjct: 333 QVKREELITNWEQIRTLAAERHARLNDSYRLQRFLADFRDLTSWVTEMKALINADELASD 392
Query: 361 LIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANRDIEKKIDDMKNLWSDL 540
+ G + L+ +HQ + E+ HE GQ ++ HYA+ ++ +K+ + + L
Sbjct: 393 VAGAEALLDRHQEHKGEIDAHEDSFKSADESGQALLAAGHYASDEVREKLTVLSEERAAL 452
Query: 541 KNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFGKDEDSTEALLKKHDAL 720
+ RRQ + ++ Q + D + ++WM ++E + + + G DS EALLKKH+
Sbjct: 453 LELWELRRQQYEQCMDLQLFYRDTEQVDNWMSKQEAFLLNEDLGDSLDSVEALLKKHEDF 512
Query: 721 MADIEAYRSTIDSL 762
+ A I +L
Sbjct: 513 EKSLSAQEEKITAL 526
Score = 137 bits (346), Expect = 3e-32
Identities = 77/259 (29%), Positives = 137/259 (52%)
Frame = +1
Query: 1 EVESQLGSDDCGKDLNSVTNLQKKHNLLESDISSHQDRIDSFLQQADQFVHDNHFDADAI 180
E L +D+ G DL SV LQ+KH E D+++ D+++S + A++ + A+ +
Sbjct: 1251 EKNQALNTDNYGHDLASVQALQRKHEGFERDLAALGDKVNSLGETAERLTQSHPESAEDL 1310
Query: 181 KKKQIEVCNRYSKLQEPLEKRKNKLNDAYKLHQFYRDADDEEDWIHEKEPIAGSTNVGRD 360
++K E+ +S L + ++RK KL D++ L +F D D WI+ + S + +D
Sbjct: 1311 QEKCTELNQAWSSLGKRADQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGLVSSDELAKD 1370
Query: 361 LIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANRDIEKKIDDMKNLWSDL 540
+ G + L+++HQ + E+ GQ+++ HYA+ +I++K+D + +DL
Sbjct: 1371 VTGAEALLERHQEHRTEIDARAGTFQAFEQFGQQLLAHGHYASPEIKQKLDILDQERADL 1430
Query: 541 KNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFGKDEDSTEALLKKHDAL 720
+ +RR +LD LE Q + D +AE+WM +E + + + G DS EAL+KKH+
Sbjct: 1431 EKAWVQRRMMLDQCLELQLFHRDCEQAENWMAAREAFLNTEDKGDSLDSVEALIKKHEDF 1490
Query: 721 MADIEAYRSTIDSLRTQAD 777
I I +L+ AD
Sbjct: 1491 DKAINVQEEKIAALQAFAD 1509
Score = 135 bits (339), Expect = 2e-31
Identities = 80/266 (30%), Positives = 141/266 (53%), Gaps = 2/266 (0%)
Frame = +1
Query: 7 ESQLGSDDCGKDLNSVTNLQKKHNLLESDISSHQDRIDSFLQQADQFVHDNHFDADAIKK 186
E+ L ++D G L+SV L KKH + I+ +++I + ADQ + H+ I
Sbjct: 1465 EAFLNTEDKGDSLDSVEALIKKHEDFDKAINVQEEKIAALQAFADQLIAAGHYAKGDISS 1524
Query: 187 KQIEVCNRYSKLQEPLEKRKNKLNDAYKLHQFYRDADDEEDWIHEKEPIAGSTNVGRDLI 366
++ EV +R+ +L+ + ++++KL ++ L QF RD D+ E WI EK A + +D
Sbjct: 1525 RRNEVLDRWRRLKAQMIEKRSKLGESQTLQQFSRDVDEIEAWISEKLQTASDESY-KDPT 1583
Query: 367 GVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANRD--IEKKIDDMKNLWSDL 540
+Q+ +KHQA +AE+ + RI V + G +I+ A + ++ ++ + + W L
Sbjct: 1584 NIQSKHQKHQAFEAELHANADRIRGVIDMGNSLIERGACAGSEDAVKARLAALADQWQFL 1643
Query: 541 KNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFGKDEDSTEALLKKHDAL 720
K+ ++ Q L ++ + Q + + + W+ E E L+ S ++GKD S LLKKH L
Sbjct: 1644 VQKSAEKSQKLKEANKQQNFNTGIKDFDFWLSEVEALLASEDYGKDLASVNNLLKKHQLL 1703
Query: 721 MADIEAYRSTIDSLRTQADACKMQEA 798
ADI A+ + L +QAD+ A
Sbjct: 1704 EADISAHEDRLKDLNSQADSLMTSSA 1729
Score = 135 bits (339), Expect = 2e-31
Identities = 68/252 (26%), Positives = 132/252 (52%), Gaps = 2/252 (0%)
Frame = +1
Query: 13 QLGSDDCGKDLNSVTNLQKKHNLLESDISSHQDRIDSFLQQADQFVHDNHF--DADAIKK 186
Q SD+ KD ++ + +KH E+++ ++ DRI + + + DA+K
Sbjct: 1572 QTASDESYKDPTNIQSKHQKHQAFEAELHANADRIRGVIDMGNSLIERGACAGSEDAVKA 1631
Query: 187 KQIEVCNRYSKLQEPLEKRKNKLNDAYKLHQFYRDADDEEDWIHEKEPIAGSTNVGRDLI 366
+ + +++ L + ++ KL +A K F D + W+ E E + S + G+DL
Sbjct: 1632 RLAALADQWQFLVQKSAEKSQKLKEANKQQNFNTGIKDFDFWLSEVEALLASEDYGKDLA 1691
Query: 367 GVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANRDIEKKIDDMKNLWSDLKN 546
V NL+KKHQ ++A+++ HE R+ ++ ++ ++ + + ++ K D + + +K+
Sbjct: 1692 SVNNLLKKHQLLEADISAHEDRLKDLNSQADSLMTSSAFDTSQVKDKRDTINGRFQKIKS 1751
Query: 547 KADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFGKDEDSTEALLKKHDALMA 726
A RR L++S Q+ D + ESW++EK+ LVGS ++G+D + L KKH L A
Sbjct: 1752 MAASRRAKLNESHRLHQFFRDMDDEESWIKEKKLLVGSEDYGRDLTGVQNLRKKHKRLEA 1811
Query: 727 DIEAYRSTIDSL 762
++ A+ I +
Sbjct: 1812 ELAAHEPAIQGV 1823
Score = 123 bits (309), Expect = 6e-28
Identities = 72/289 (24%), Positives = 137/289 (47%), Gaps = 36/289 (12%)
Frame = +1
Query: 1 EVESQLGSDDCGKDLNSVTNLQKKHNLLESDISSHQDRIDSFLQQADQFVHDNHF--DAD 174
E E+ L S++ G DL V LQKK + + D+ +++ R+ + A+ + +
Sbjct: 1109 EKEAALTSEEVGADLEQVEVLQKKFDDFQKDLKANESRLKDINKVAEDLESEGLMAEEVQ 1168
Query: 175 AIKKKQI----------------------------------EVCNRYSKLQEPLEKRKNK 252
A++++++ E+ R+ LQ+ E+R
Sbjct: 1169 AVQQQEVYGMMPRDETDSKTASPWKSARLMVHTVATFNSIKELNERWRSLQQLAEERSQL 1228
Query: 253 LNDAYKLHQFYRDADDEEDWIHEKEPIAGSTNVGRDLIGVQNLIKKHQAIQAEVTGHEPR 432
L A+++ +F+RDAD+ ++WI EK + N G DL VQ L +KH+ + ++ +
Sbjct: 1229 LGSAHEVQRFHRDADETKEWIEEKNQALNTDNYGHDLASVQALQRKHEGFERDLAALGDK 1288
Query: 433 ILEVCNEGQKMIDGNHYANRDIEKKIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYLADA 612
+ + +++ + + D+++K ++ WS L +AD+R+ L DS + Q++L+D
Sbjct: 1289 VNSLGETAERLTQSHPESAEDLQEKCTELNQAWSSLGKRADQRKAKLGDSHDLQRFLSDF 1348
Query: 613 SEAESWMREKEPLVGSTEFGKDEDSTEALLKKHDALMADIEAYRSTIDS 759
+ SW+ LV S E KD EALL++H +I+A T +
Sbjct: 1349 RDLMSWINGIRGLVSSDELAKDVTGAEALLERHQEHRTEIDARAGTFQA 1397
Score = 122 bits (307), Expect = 1e-27
Identities = 67/254 (26%), Positives = 128/254 (50%)
Frame = +1
Query: 1 EVESQLGSDDCGKDLNSVTNLQKKHNLLESDISSHQDRIDSFLQQADQFVHDNHFDADAI 180
E+++ + +D+ D+ L +H + +I +H+D S + + H+ +D +
Sbjct: 379 EMKALINADELASDVAGAEALLDRHQEHKGEIDAHEDSFKSADESGQALLAAGHYASDEV 438
Query: 181 KKKQIEVCNRYSKLQEPLEKRKNKLNDAYKLHQFYRDADDEEDWIHEKEPIAGSTNVGRD 360
++K + + L E E R+ + L FYRD + ++W+ ++E + ++G
Sbjct: 439 REKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRDTEQVDNWMSKQEAFLLNEDLGDS 498
Query: 361 LIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANRDIEKKIDDMKNLWSDL 540
L V+ L+KKH+ + ++ E +I + K+I NHYA D+ + D + + + L
Sbjct: 499 LDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNHYAMEDVATRRDALLSRRNAL 558
Query: 541 KNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFGKDEDSTEALLKKHDAL 720
+A +RR L DS QQ+ D+ E +SW+ EK + E KD + + ++KH A
Sbjct: 559 HERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKMK-TATDEAYKDPSNLQGKVQKHQAF 617
Query: 721 MADIEAYRSTIDSL 762
A++ A +S ID+L
Sbjct: 618 EAELSANQSRIDAL 631
Score = 113 bits (283), Expect = 6e-25
Identities = 62/211 (29%), Positives = 110/211 (52%)
Frame = +1
Query: 169 ADAIKKKQIEVCNRYSKLQEPLEKRKNKLNDAYKLHQFYRDADDEEDWIHEKEPIAGSTN 348
A+ I++++ +V +RY + +E R+ KL D+Y+ F RDA++ E WI EK IA N
Sbjct: 12 AEDIQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDAEELEKWIQEKLQIASDEN 71
Query: 349 VGRDLIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANRDIEKKIDDMKNL 528
+D +Q ++KHQA +AEV + I+++ G MI H+A+ I ++ ++
Sbjct: 72 Y-KDPTNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETIRTRLMELHRQ 130
Query: 529 WSDLKNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFGKDEDSTEALLKK 708
W L K ++ L + + QYL + + W+ +KE +V S E G+D + E L KK
Sbjct: 131 WELLLEKMREKGIKLLQAQKLVQYLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQKK 190
Query: 709 HDALMADIEAYRSTIDSLRTQADACKMQEAP 801
+ D+ A+ ++ + A ++ P
Sbjct: 191 FEEFQTDMAAHEERVNEVNQFAAKLIQEQHP 221
Score = 106 bits (265), Expect = 7e-23
Identities = 63/245 (25%), Positives = 117/245 (47%)
Frame = +1
Query: 4 VESQLGSDDCGKDLNSVTNLQKKHNLLESDISSHQDRIDSFLQQADQFVHDNHFDADAIK 183
+ + SD+ KD+ L ++H ++I + +F Q Q + H+ + IK
Sbjct: 1358 IRGLVSSDELAKDVTGAEALLERHQEHRTEIDARAGTFQAFEQFGQQLLAHGHYASPEIK 1417
Query: 184 KKQIEVCNRYSKLQEPLEKRKNKLNDAYKLHQFYRDADDEEDWIHEKEPIAGSTNVGRDL 363
+K + + L++ +R+ L+ +L F+RD + E+W+ +E + + G L
Sbjct: 1418 QKLDILDQERADLEKAWVQRRMMLDQCLELQLFHRDCEQAENWMAAREAFLNTEDKGDSL 1477
Query: 364 IGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANRDIEKKIDDMKNLWSDLK 543
V+ LIKKH+ + E +I + ++I HYA DI + +++ + W LK
Sbjct: 1478 DSVEALIKKHEDFDKAINVQEEKIAALQAFADQLIAAGHYAKGDISSRRNEVLDRWRRLK 1537
Query: 544 NKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFGKDEDSTEALLKKHDALM 723
+ ++R L +S QQ+ D E E+W+ EK S E KD + ++ +KH A
Sbjct: 1538 AQMIEKRSKLGESQTLQQFSRDVDEIEAWISEKLQ-TASDESYKDPTNIQSKHQKHQAFE 1596
Query: 724 ADIEA 738
A++ A
Sbjct: 1597 AELHA 1601
Score = 89.0 bits (219), Expect = 2e-17
Identities = 69/275 (25%), Positives = 120/275 (43%), Gaps = 39/275 (14%)
Frame = +1
Query: 70 KHNLLESD--ISSHQDRIDSFLQQADQFVHDNHFDADAIKKKQIEVCNRYSKLQEPLEKR 243
+ NLLE I+ Q++ID+ Q + +++ KQ+E Y L E EKR
Sbjct: 1032 RENLLEEQGSIALRQEQIDN------QTRITKEAGSVSLRMKQVE--ELYHSLLELGEKR 1083
Query: 244 KNKLNDAYKLHQFYRDADDEEDWIHEKEPIAGSTNVGRDLIGVQNLIKKHQAIQAEVTGH 423
K L + K +R+A++ + WI+EKE S VG DL V+ L KK Q ++ +
Sbjct: 1084 KGMLEKSCKKFMLFREANELQQWINEKEAALTSEEVGADLEQVEVLQKKFDDFQKDLKAN 1143
Query: 424 EPRILEVCNEGQKMIDGNHYANRDIE---------------------------------- 501
E R+ ++ N+ + ++ +++
Sbjct: 1144 ESRLKDI-NKVAEDLESEGLMAEEVQAVQQQEVYGMMPRDETDSKTASPWKSARLMVHTV 1202
Query: 502 ---KKIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFG 672
I ++ W L+ A++R QLL + E Q++ DA E + W+ EK + + +G
Sbjct: 1203 ATFNSIKELNERWRSLQQLAEERSQLLGSAHEVQRFHRDADETKEWIEEKNQALNTDNYG 1262
Query: 673 KDEDSTEALLKKHDALMADIEAYRSTIDSLRTQAD 777
D S +AL +KH+ D+ A ++SL A+
Sbjct: 1263 HDLASVQALQRKHEGFERDLAALGDKVNSLGETAE 1297
Score = 59.7 bits (143), Expect = 1e-08
Identities = 69/294 (23%), Positives = 123/294 (41%), Gaps = 23/294 (7%)
Frame = +1
Query: 1 EVESQLGSDDCGKDLNSVTNLQKKHNLLESDISS-HQDRIDSFLQQADQFVHDNHFDADA 177
E E+ L +DD G+DL+SV L K ++ + + Q+ I + DQ + H + A
Sbjct: 1994 EKENSLKTDDYGRDLSSVQTLLTKQETFDAGLQAFQQEGIANITALKDQLLAAKHVQSKA 2053
Query: 178 IKKKQIEVCNRYSKLQEPLEKRKNKLNDAYKLHQ--------FYRDADDEEDWIHEKEPI 333
I+ + + R+S+L RK KL +A + F + A W E
Sbjct: 2054 IEARHASLMKRWSQLLANSAARKKKLLEAQSHFRKVEDLFLTFAKKASAFNSWFENAEED 2113
Query: 334 AGSTNVGRDLIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKM----IDGNHYANRDIE 501
L ++ L + H A ++ ++ + ++ +++ + N Y +E
Sbjct: 2114 LTDPVRCNSLEEIKALREAHDAFRSSLSSAQADFNQLAELDRQIKSFRVASNPYTWFTME 2173
Query: 502 KKIDDMKNLWSDLKNK-----ADKRRQLLDDSLEAQQYLADASEAESWMREKEP--LVGS 660
+ +NL +K + ++RRQ +D L Q++ A+ W++E L GS
Sbjct: 2174 ALEETWRNLQKIIKERELELQKEQRRQEENDKLR-QEFAQHANAFHQWIQETRTYLLDGS 2232
Query: 661 ---TEFGKDEDSTEALLKKHDALMADIEAYRSTIDSLRTQADACKMQEAPVSDS 813
E G E EA +KH +I A RS + + A M+EA + D+
Sbjct: 2233 CMVEESGTLESQLEATKRKHQ----EIRAMRSQLKKIEDLGAA--MEEALILDN 2280
>sp|P07751|SPTA2_CHICK Spectrin alpha chain, brain (Spectrin, non-erythroid alpha chain)
(Fodrin alpha chain)
Length = 2477
Score = 354 bits (909), Expect = 2e-97
Identities = 172/284 (60%), Positives = 214/284 (75%)
Frame = +1
Query: 1 EVESQLGSDDCGKDLNSVTNLQKKHNLLESDISSHQDRIDSFLQQADQFVHDNHFDADAI 180
EVE L SDD GKDL SV NLQKKH LLE+D+++HQD ID QA QF HFDAD I
Sbjct: 696 EVEGHLASDDYGKDLTSVQNLQKKHALLEADVAAHQDPIDGITIQARQFQDAGHFDADNI 755
Query: 181 KKKQIEVCNRYSKLQEPLEKRKNKLNDAYKLHQFYRDADDEEDWIHEKEPIAGSTNVGRD 360
KKKQ + RY L++P+ RK KL D+ +L Q +RD +DEE WI EKEPIA STN G+D
Sbjct: 756 KKKQEALVARYEALKDPMVARKQKLADSLRLQQLFRDIEDEETWIREKEPIAASTNRGKD 815
Query: 361 LIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANRDIEKKIDDMKNLWSDL 540
LIGVQNL+KKHQA+QAE+ GHEPRI V +G M++ H+A D++ K++++ W L
Sbjct: 816 LIGVQNLLKKHQALQAEIAGHEPRIKAVTQKGNAMVEEGHFAAEDVKIKLNELNQKWDSL 875
Query: 541 KNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFGKDEDSTEALLKKHDAL 720
K KA +RRQ L+DSL+AQQY ADA+EA+SWMREKEP+VGST++GKDEDS EALLKKH+AL
Sbjct: 876 KAKASQRRQDLEDSLQAQQYFADANEAQSWMREKEPIVGSTDYGKDEDSAEALLKKHEAL 935
Query: 721 MADIEAYRSTIDSLRTQADACKMQEAPVSDSYGKETVMALYDYQ 852
M+D+ AY S+I +LR QA +C+ Q AP D GKE V+ALYDYQ
Sbjct: 936 MSDLSAYGSSIQALREQAQSCRQQVAPTDDETGKELVLALYDYQ 979
Score = 219 bits (558), Expect = 8e-57
Identities = 106/254 (41%), Positives = 161/254 (63%)
Frame = +1
Query: 1 EVESQLGSDDCGKDLNSVTNLQKKHNLLESDISSHQDRIDSFLQQADQFVHDNHFDADAI 180
EVE+ L S+D GKDL SV NL KKH LLE+DIS+H+DR+ QAD + + FD +
Sbjct: 1681 EVEALLASEDYGKDLASVNNLLKKHQLLEADISAHEDRLKDLNSQADSLMTSSAFDTSQV 1740
Query: 181 KKKQIEVCNRYSKLQEPLEKRKNKLNDAYKLHQFYRDADDEEDWIHEKEPIAGSTNVGRD 360
K K+ + R+ +++ R+ KLN++++LHQF+RD DDEE WI EK+ + S + GRD
Sbjct: 1741 KDKRETINGRFQRIKSMAAARRAKLNESHRLHQFFRDMDDEESWIKEKKLLVSSEDYGRD 1800
Query: 361 LIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANRDIEKKIDDMKNLWSDL 540
L GVQNL KKH+ ++AE+ HEP I V + G+K+ D N +I++++ + W +L
Sbjct: 1801 LTGVQNLRKKHKRLEAELAAHEPAIQGVLDTGKKLSDDNTIGKEEIQQRLAQFVDHWKEL 1860
Query: 541 KNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFGKDEDSTEALLKKHDAL 720
K A R Q L++SLE QQ++A+ E E+W+ EK LV S ++G + + LLKKH+A
Sbjct: 1861 KQLAAARGQRLEESLEYQQFVANVEEEEAWINEKMTLVASEDYGDTLAAIQGLLKKHEAF 1920
Query: 721 MADIEAYRSTIDSL 762
D ++ ++ +
Sbjct: 1921 ETDFTVHKDRVNDV 1934
Score = 158 bits (399), Expect = 2e-38
Identities = 85/253 (33%), Positives = 142/253 (56%)
Frame = +1
Query: 22 SDDCGKDLNSVTNLQKKHNLLESDISSHQDRIDSFLQQADQFVHDNHFDADAIKKKQIEV 201
+D+ KD +++ +KH E+++S++Q RID+ + + + NH+ +D + + EV
Sbjct: 597 TDEAYKDPSNLQGKVQKHQAFEAELSANQSRIDALEKAGQKLIDVNHYASDEVAARMNEV 656
Query: 202 CNRYSKLQEPLEKRKNKLNDAYKLHQFYRDADDEEDWIHEKEPIAGSTNVGRDLIGVQNL 381
+ + KL E E + KL +A + QF R+ +D E W++E E S + G+DL VQNL
Sbjct: 657 ISLWKKLLEATELKGIKLREANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDLTSVQNL 716
Query: 382 IKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANRDIEKKIDDMKNLWSDLKNKADKR 561
KKH ++A+V H+ I + + ++ D H+ +I+KK + + + LK+ R
Sbjct: 717 QKKHALLEADVAAHQDPIDGITIQARQFQDAGHFDADNIKKKQEALVARYEALKDPMVAR 776
Query: 562 RQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFGKDEDSTEALLKKHDALMADIEAY 741
+Q L DSL QQ D + E+W+REKEP+ ST GKD + LLKKH AL A+I +
Sbjct: 777 KQKLADSLRLQQLFRDIEDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGH 836
Query: 742 RSTIDSLRTQADA 780
I ++ + +A
Sbjct: 837 EPRIKAVTQKGNA 849
Score = 152 bits (383), Expect = 1e-36
Identities = 85/267 (31%), Positives = 146/267 (54%)
Frame = +1
Query: 13 QLGSDDCGKDLNSVTNLQKKHNLLESDISSHQDRIDSFLQQADQFVHDNHFDADAIKKKQ 192
Q+ SD+ KD +++ +KH E+++ ++ I + +Q +++ HF ++ I+ +
Sbjct: 65 QIASDENYKDPSNLQGKLQKHQAFEAEVQANSGAIVKLDETGNQMINEGHFASETIRTRL 124
Query: 193 IEVCNRYSKLQEPLEKRKNKLNDAYKLHQFYRDADDEEDWIHEKEPIAGSTNVGRDLIGV 372
E+ + L E + ++ KL A KL QF R+ +D DWI++KE I S +G+DL V
Sbjct: 125 QELHRLWELLLEKMREKGVKLLQAQKLVQFLRECEDVMDWINDKEAIVTSEELGQDLEHV 184
Query: 373 QNLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANRDIEKKIDDMKNLWSDLKNKA 552
+ L KK + Q ++ HE R+ EV K+I H I+ K D++ W LK A
Sbjct: 185 EVLQKKFEEFQTDLAAHEERVNEVNQFAGKLIQEQHPEEELIKSKQDEVNASWQRLKGLA 244
Query: 553 DKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFGKDEDSTEALLKKHDALMADI 732
+R+ L + E Q++ D E SW++EK L+ S +FG+D S +ALL+KH+ L D+
Sbjct: 245 QQRQGKLFGAAEVQRFNRDVDETISWIKEKGQLMASDDFGRDLASVQALLRKHEGLERDL 304
Query: 733 EAYRSTIDSLRTQADACKMQEAPVSDS 813
A+ + +L +AD + Q P++ S
Sbjct: 305 AAFHHKVKALCAEADRLQ-QSHPINAS 330
Score = 149 bits (375), Expect = 1e-35
Identities = 78/261 (29%), Positives = 145/261 (55%), Gaps = 4/261 (1%)
Frame = +1
Query: 16 LGSDDCGKDLNSVTNLQKKHNLLESDISSHQDRIDSFLQQADQFVHDNHFDADAIKKKQI 195
+ S+D G+DL V NL+KKH LE+++++H+ I L + DN + I+++
Sbjct: 1792 VSSEDYGRDLTGVQNLRKKHKRLEAELAAHEPAIQGVLDTGKKLSDDNTIGKEEIQQRLA 1851
Query: 196 EVCNRYSKLQEPLEKRKNKLNDAYKLHQFYRDADDEEDWIHEKEPIAGSTNVGRDLIGVQ 375
+ + + +L++ R +L ++ + QF + ++EE WI+EK + S + G L +Q
Sbjct: 1852 QFVDHWKELKQLAAARGQRLEESLEYQQFVANVEEEEAWINEKMTLVASEDYGDTLAAIQ 1911
Query: 376 NLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANRDIEKKIDDMKNLWSDLKNKAD 555
L+KKH+A + + T H+ R+ +VC G+ +I N++ +I K+ +K SDL+ A
Sbjct: 1912 GLLKKHEAFETDFTVHKDRVNDVCANGEDLIKKNNHHVENITAKMKGLKGKVSDLEKAAA 1971
Query: 556 KRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFGKDEDSTEALLKKHDALMADIE 735
+R+ LD++ Q+ A ESW+ EKE + + ++G+D S + LL K + A ++
Sbjct: 1972 QRKAKLDENSAFLQFNWKADVVESWIGEKENSLKTDDYGRDLSSVQTLLTKQETFDAGLQ 2031
Query: 736 AYR----STIDSLRTQADACK 786
A++ + I +L+ Q A K
Sbjct: 2032 AFQQEGIANITALKDQLLAAK 2052
Score = 143 bits (361), Expect = 5e-34
Identities = 80/280 (28%), Positives = 145/280 (51%)
Frame = +1
Query: 7 ESQLGSDDCGKDLNSVTNLQKKHNLLESDISSHQDRIDSFLQQADQFVHDNHFDADAIKK 186
E+ + S++ G+DL V LQKK ++D+++H++R++ Q A + + + H + + IK
Sbjct: 169 EAIVTSEELGQDLEHVEVLQKKFEEFQTDLAAHEERVNEVNQFAGKLIQEQHPEEELIKS 228
Query: 187 KQIEVCNRYSKLQEPLEKRKNKLNDAYKLHQFYRDADDEEDWIHEKEPIAGSTNVGRDLI 366
KQ EV + +L+ ++R+ KL A ++ +F RD D+ WI EK + S + GRDL
Sbjct: 229 KQDEVNASWQRLKGLAQQRQGKLFGAAEVQRFNRDVDETISWIKEKGQLMASDDFGRDLA 288
Query: 367 GVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANRDIEKKIDDMKNLWSDLKN 546
VQ L++KH+ ++ ++ ++ +C E ++ + I+ K +++ W ++
Sbjct: 289 SVQALLRKHEGLERDLAAFHHKVKALCAEADRLQQSHPINASQIQVKREELIANWEQIRT 348
Query: 547 KADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFGKDEDSTEALLKKHDALMA 726
A +R L+DS Q++LAD + SW+ E + L+ + E D EALL +H
Sbjct: 349 LAAERHARLNDSYRLQRFLADFRDLTSWVTEMKALINADELANDVAGAEALLDRHQEHKG 408
Query: 727 DIEAYRSTIDSLRTQADACKMQEAPVSDSYGKETVMALYD 846
+I+A+ + S A SD KE + L D
Sbjct: 409 EIDAHEDSFRSADESGQALLAAGHYASDEV-KEKLTILSD 447
Score = 135 bits (339), Expect = 2e-31
Identities = 68/249 (27%), Positives = 130/249 (52%)
Frame = +1
Query: 16 LGSDDCGKDLNSVTNLQKKHNLLESDISSHQDRIDSFLQQADQFVHDNHFDADAIKKKQI 195
+ SDD G+DL SV L +KH LE D+++ ++ + +AD+ + +A I+ K+
Sbjct: 278 MASDDFGRDLASVQALLRKHEGLERDLAAFHHKVKALCAEADRLQQSHPINASQIQVKRE 337
Query: 196 EVCNRYSKLQEPLEKRKNKLNDAYKLHQFYRDADDEEDWIHEKEPIAGSTNVGRDLIGVQ 375
E+ + +++ +R +LND+Y+L +F D D W+ E + + + + D+ G +
Sbjct: 338 ELIANWEQIRTLAAERHARLNDSYRLQRFLADFRDLTSWVTEMKALINADELANDVAGAE 397
Query: 376 NLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANRDIEKKIDDMKNLWSDLKNKAD 555
L+ +HQ + E+ HE GQ ++ HYA+ ++++K+ + + S L +
Sbjct: 398 ALLDRHQEHKGEIDAHEDSFRSADESGQALLAAGHYASDEVKEKLTILSDERSALLELWE 457
Query: 556 KRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFGKDEDSTEALLKKHDALMADIE 735
RRQ + ++ Q + D + ++WM ++E + + + G DS EALLKKH+ +
Sbjct: 458 LRRQQYEQCMDLQLFYRDTEQVDNWMSKQEAFLLNEDLGDSLDSVEALLKKHEDFEKSLS 517
Query: 736 AYRSTIDSL 762
A I +L
Sbjct: 518 AQEEKITAL 526
Score = 131 bits (330), Expect = 2e-30
Identities = 78/277 (28%), Positives = 141/277 (50%)
Frame = +1
Query: 1 EVESQLGSDDCGKDLNSVTNLQKKHNLLESDISSHQDRIDSFLQQADQFVHDNHFDADAI 180
E L +D+ G DL SV LQ+ E D+++ D+++S + A + + + A+ +
Sbjct: 1251 EKNQALNTDNYGHDLASVQALQRNDEGFERDLAALGDKVNSLGETAQRLIQSHPELAEDL 1310
Query: 181 KKKQIEVCNRYSKLQEPLEKRKNKLNDAYKLHQFYRDADDEEDWIHEKEPIAGSTNVGRD 360
++K E+ +S L + ++RK KL D++ L +F D D WI+ + S + +D
Sbjct: 1311 QEKCTELNQAWSSLGKRADQRKEKLGDSHDLQRFLSDFRDLMSWINGIRGLVSSDELAKD 1370
Query: 361 LIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANRDIEKKIDDMKNLWSDL 540
+ G + L+++HQ + E+ GQ+++ HYA+ +I++K+D + +DL
Sbjct: 1371 VTGAEALLERHQEHRTEIDARAGTFQAFEQFGQQLLARGHYASPEIKEKLDILDQERTDL 1430
Query: 541 KNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFGKDEDSTEALLKKHDAL 720
+ +RR +LD LE Q + D +AE+WM +E + + + G DS EAL+KKH+
Sbjct: 1431 EKAWVQRRMMLDQCLELQLFHRDCEQAENWMAAREAFLNTEDKGDSLDSVEALIKKHEDF 1490
Query: 721 MADIEAYRSTIDSLRTQADACKMQEAPVSDSYGKETV 831
I I L++ AD + +D Y K +
Sbjct: 1491 DKAINVQEEKIAVLQSFAD-----QLIAADHYAKGVI 1522
Score = 129 bits (324), Expect = 1e-29
Identities = 81/272 (29%), Positives = 140/272 (51%), Gaps = 8/272 (2%)
Frame = +1
Query: 7 ESQLGSDDCGKDLNSVTNLQKKHNLLESDISSHQDRIDSFLQQADQFVHDNHFDADAIKK 186
E+ L ++D G L+SV L KKH + I+ +++I ADQ + +H+ I
Sbjct: 1465 EAFLNTEDKGDSLDSVEALIKKHEDFDKAINVQEEKIAVLQSFADQLIAADHYAKGVIAN 1524
Query: 187 KQIEVCNRYSKLQEPLEKRKNKLNDAYKLHQFYRDADDEEDWIHEK------EPIAGSTN 348
++ EV +R+ +L+ + ++++KL ++ L QF RD D+ E WI EK E TN
Sbjct: 1525 RRNEVLDRWRRLKAQMIEKRSKLGESQTLQQFSRDVDEIEAWISEKLQTASDESYKDPTN 1584
Query: 349 VGRDLIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANRD--IEKKIDDMK 522
+ L + + +KHQA +AE+ + RI V G +I+ A + ++ ++ +
Sbjct: 1585 I--QLSKLLSKHQKHQAFEAELHANADRIRGVIEMGNPLIERGACAGSEDAVKARLAALA 1642
Query: 523 NLWSDLKNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFGKDEDSTEALL 702
+ W L K+ ++ Q L ++ + Q + + + W+ E E L+ S ++GKD S LL
Sbjct: 1643 DQWEFLVQKSSEKSQKLKEANKQQNFNTGIKDFDFWLSEVEALLASEDYGKDLASVNNLL 1702
Query: 703 KKHDALMADIEAYRSTIDSLRTQADACKMQEA 798
KKH L ADI A+ + L +QAD+ A
Sbjct: 1703 KKHQLLEADISAHEDRLKDLNSQADSLMTSSA 1734
Score = 127 bits (318), Expect = 5e-29
Identities = 67/257 (26%), Positives = 133/257 (51%), Gaps = 7/257 (2%)
Frame = +1
Query: 13 QLGSDDCGKD-----LNSVTNLQKKHNLLESDISSHQDRIDSFLQQADQFVHDNHF--DA 171
Q SD+ KD L+ + + +KH E+++ ++ DRI ++ + +
Sbjct: 1572 QTASDESYKDPTNIQLSKLLSKHQKHQAFEAELHANADRIRGVIEMGNPLIERGACAGSE 1631
Query: 172 DAIKKKQIEVCNRYSKLQEPLEKRKNKLNDAYKLHQFYRDADDEEDWIHEKEPIAGSTNV 351
DA+K + + +++ L + ++ KL +A K F D + W+ E E + S +
Sbjct: 1632 DAVKARLAALADQWEFLVQKSSEKSQKLKEANKQQNFNTGIKDFDFWLSEVEALLASEDY 1691
Query: 352 GRDLIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANRDIEKKIDDMKNLW 531
G+DL V NL+KKHQ ++A+++ HE R+ ++ ++ ++ + + ++ K + + +
Sbjct: 1692 GKDLASVNNLLKKHQLLEADISAHEDRLKDLNSQADSLMTSSAFDTSQVKDKRETINGRF 1751
Query: 532 SDLKNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFGKDEDSTEALLKKH 711
+K+ A RR L++S Q+ D + ESW++EK+ LV S ++G+D + L KKH
Sbjct: 1752 QRIKSMAAARRAKLNESHRLHQFFRDMDDEESWIKEKKLLVSSEDYGRDLTGVQNLRKKH 1811
Query: 712 DALMADIEAYRSTIDSL 762
L A++ A+ I +
Sbjct: 1812 KRLEAELAAHEPAIQGV 1828
Score = 125 bits (313), Expect = 2e-28
Identities = 70/254 (27%), Positives = 129/254 (50%)
Frame = +1
Query: 1 EVESQLGSDDCGKDLNSVTNLQKKHNLLESDISSHQDRIDSFLQQADQFVHDNHFDADAI 180
E+++ + +D+ D+ L +H + +I +H+D S + + H+ +D +
Sbjct: 379 EMKALINADELANDVAGAEALLDRHQEHKGEIDAHEDSFRSADESGQALLAAGHYASDEV 438
Query: 181 KKKQIEVCNRYSKLQEPLEKRKNKLNDAYKLHQFYRDADDEEDWIHEKEPIAGSTNVGRD 360
K+K + + S L E E R+ + L FYRD + ++W+ ++E + ++G
Sbjct: 439 KEKLTILSDERSALLELWELRRQQYEQCMDLQLFYRDTEQVDNWMSKQEAFLLNEDLGDS 498
Query: 361 LIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANRDIEKKIDDMKNLWSDL 540
L V+ L+KKH+ + ++ E +I + K+I NHYA D+ + D + + + L
Sbjct: 499 LDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNHYAMDDVATRRDALLSRRNAL 558
Query: 541 KNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFGKDEDSTEALLKKHDAL 720
+A KRR L DS QQ+ D+ E +SW+ EK + E KD + + ++KH A
Sbjct: 559 HERAMKRRAQLADSFHLQQFFRDSDELKSWVNEKMK-TATDEAYKDPSNLQGKVQKHQAF 617
Query: 721 MADIEAYRSTIDSL 762
A++ A +S ID+L
Sbjct: 618 EAELSANQSRIDAL 631
Score = 117 bits (293), Expect = 4e-26
Identities = 71/289 (24%), Positives = 134/289 (46%), Gaps = 36/289 (12%)
Frame = +1
Query: 1 EVESQLGSDDCGKDLNSVTNLQKKHNLLESDISSHQDRIDSFLQQADQFVHDNHF--DAD 174
E E+ L +++ G DL V LQKK + + D+ +++ R+ + A+ + +
Sbjct: 1109 EKEAALTNEEVGADLEQVEVLQKKFDDFQKDLKANESRLKDINKVANDLESEGLMAEEVQ 1168
Query: 175 AIKKKQI----------------------------------EVCNRYSKLQEPLEKRKNK 252
A++ +++ E+ R+ LQ+ E+R
Sbjct: 1169 AVEHQEVYGMMPRDETDSKTVSPWKSARMMVHTVATFNSIKELNERWRSLQQLAEERSQL 1228
Query: 253 LNDAYKLHQFYRDADDEEDWIHEKEPIAGSTNVGRDLIGVQNLIKKHQAIQAEVTGHEPR 432
L A ++ +F+RDAD+ ++WI EK + N G DL VQ L + + + ++ +
Sbjct: 1229 LGSADEVQRFHRDADETKEWIEEKNQALNTDNYGHDLASVQALQRNDEGFERDLAALGDK 1288
Query: 433 ILEVCNEGQKMIDGNHYANRDIEKKIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYLADA 612
+ + Q++I + D+++K ++ WS L +AD+R++ L DS + Q++L+D
Sbjct: 1289 VNSLGETAQRLIQSHPELAEDLQEKCTELNQAWSSLGKRADQRKEKLGDSHDLQRFLSDF 1348
Query: 613 SEAESWMREKEPLVGSTEFGKDEDSTEALLKKHDALMADIEAYRSTIDS 759
+ SW+ LV S E KD EALL++H +I+A T +
Sbjct: 1349 RDLMSWINGIRGLVSSDELAKDVTGAEALLERHQEHRTEIDARAGTFQA 1397
Score = 117 bits (292), Expect = 5e-26
Identities = 62/211 (29%), Positives = 112/211 (53%)
Frame = +1
Query: 169 ADAIKKKQIEVCNRYSKLQEPLEKRKNKLNDAYKLHQFYRDADDEEDWIHEKEPIAGSTN 348
A+ I++++ +V +RY + +E R+ KL D+Y+ F RDAD+ WI EK IA N
Sbjct: 12 AEDIQERRQQVLDRYHRFKELSSLRRQKLEDSYRFQFFQRDADELGKWIQEKLQIASDEN 71
Query: 349 VGRDLIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANRDIEKKIDDMKNL 528
+D +Q ++KHQA +AEV + I+++ G +MI+ H+A+ I ++ ++ L
Sbjct: 72 Y-KDPSNLQGKLQKHQAFEAEVQANSGAIVKLDETGNQMINEGHFASETIRTRLQELHRL 130
Query: 529 WSDLKNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFGKDEDSTEALLKK 708
W L K ++ L + + Q+L + + W+ +KE +V S E G+D + E L KK
Sbjct: 131 WELLLEKMREKGVKLLQAQKLVQFLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQKK 190
Query: 709 HDALMADIEAYRSTIDSLRTQADACKMQEAP 801
+ D+ A+ ++ + A ++ P
Sbjct: 191 FEEFQTDLAAHEERVNEVNQFAGKLIQEQHP 221
Score = 98.2 bits (243), Expect = 3e-20
Identities = 64/256 (25%), Positives = 118/256 (46%), Gaps = 2/256 (0%)
Frame = +1
Query: 4 VESQLGSDDCGKDLNSVTNLQKKHNLLESDISSHQDRIDSFLQQADQFVHDNHFDADAIK 183
+ + SD+ KD+ L ++H ++I + +F Q Q + H+ + IK
Sbjct: 1358 IRGLVSSDELAKDVTGAEALLERHQEHRTEIDARAGTFQAFEQFGQQLLARGHYASPEIK 1417
Query: 184 KKQIEVCNRYSKLQEPLEKRKNKLNDAYKLHQFYRDADDEEDWIHEKEPIAGSTNVGRDL 363
+K + + L++ +R+ L+ +L F+RD + E+W+ +E + + G L
Sbjct: 1418 EKLDILDQERTDLEKAWVQRRMMLDQCLELQLFHRDCEQAENWMAAREAFLNTEDKGDSL 1477
Query: 364 IGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANRDIEKKIDDMKNLWSDLK 543
V+ LIKKH+ + E +I + + ++I +HYA I + +++ + W LK
Sbjct: 1478 DSVEALIKKHEDFDKAINVQEEKIAVLQSFADQLIAADHYAKGVIANRRNEVLDRWRRLK 1537
Query: 544 NKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFGKDEDSTE--ALLKKHDA 717
+ ++R L +S QQ+ D E E+W+ EK S E KD + + LL KH
Sbjct: 1538 AQMIEKRSKLGESQTLQQFSRDVDEIEAWISEKLQ-TASDESYKDPTNIQLSKLLSKHQK 1596
Query: 718 LMADIEAYRSTIDSLR 765
A + D +R
Sbjct: 1597 HQAFEAELHANADRIR 1612
Score = 82.8 bits (203), Expect = 1e-15
Identities = 65/270 (24%), Positives = 116/270 (42%), Gaps = 39/270 (14%)
Frame = +1
Query: 70 KHNLLESD--ISSHQDRIDSFLQQADQFVHDNHFDADAIKKKQIEVCNRYSKLQEPLEKR 243
+ NLLE I+ Q++ID+ Q + + +++ KQ+E Y L E EKR
Sbjct: 1032 RENLLEEQGSIALRQEQIDN------QTLITKEVGSVSLRMKQVE--ELYHSLLELGEKR 1083
Query: 244 KNKLNDAYKLHQFYRDADDEEDWIHEKEPIAGSTNVGRDLIGVQNLIKKHQAIQAEVTGH 423
K L + K +R+A++ + WI+EKE + VG DL V+ L KK Q ++ +
Sbjct: 1084 KGMLEKSCKKFMLFREANELQQWINEKEAALTNEEVGADLEQVEVLQKKFDDFQKDLKAN 1143
Query: 424 EPRILEVCNEGQKMIDGNHYANRDIE---------------------------------- 501
E R+ ++ N+ ++ +++
Sbjct: 1144 ESRLKDI-NKVANDLESEGLMAEEVQAVEHQEVYGMMPRDETDSKTVSPWKSARMMVHTV 1202
Query: 502 ---KKIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFG 672
I ++ W L+ A++R QLL + E Q++ DA E + W+ EK + + +G
Sbjct: 1203 ATFNSIKELNERWRSLQQLAEERSQLLGSADEVQRFHRDADETKEWIEEKNQALNTDNYG 1262
Query: 673 KDEDSTEALLKKHDALMADIEAYRSTIDSL 762
D S +AL + + D+ A ++SL
Sbjct: 1263 HDLASVQALQRNDEGFERDLAALGDKVNSL 1292
Score = 64.3 bits (155), Expect = 4e-10
Identities = 62/272 (22%), Positives = 112/272 (41%), Gaps = 13/272 (4%)
Frame = +1
Query: 1 EVESQLGSDDCGKDLNSVTNLQKKHNLLESDISSHQDRIDSFLQQADQFVHDNHFDADAI 180
E E +GS D GKD +S L KKH L SD+S++ I + +QA D
Sbjct: 908 EKEPIVGSTDYGKDEDSAEALLKKHEALMSDLSAYGSSIQALREQAQSCRQQVAPTDDET 967
Query: 181 KKKQIEVCNRYSKLQEPLEKRKNK------LN----DAYKLHQFYRDADDEEDWIHEKEP 330
K+ + Y + + P E K LN D +K+ R ++ + +P
Sbjct: 968 GKELVLALYDYQE-KSpreVTMKKGDILTLLNSTNKDWWKVEVNDRQGFVPAAYVKKLDP 1026
Query: 331 IAGSTNVGRDLIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANRDIEK-- 504
++ +NL+++ +I Q+ ID +++
Sbjct: 1027 AQSASR--------ENLLEEQGSIALR---------------QEQIDNQTLITKEVGSVS 1063
Query: 505 -KIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFGKDE 681
++ ++ L+ L +KR+ +L+ S + +A+E + W+ EKE + + E G D
Sbjct: 1064 LRMKQVEELYHSLLELGEKRKGMLEKSCKKFMLFREANELQQWINEKEAALTNEEVGADL 1123
Query: 682 DSTEALLKKHDALMADIEAYRSTIDSLRTQAD 777
+ E L KK D D++A S + + A+
Sbjct: 1124 EQVEVLQKKFDDFQKDLKANESRLKDINKVAN 1155
Score = 58.9 bits (141), Expect = 2e-08
Identities = 68/294 (23%), Positives = 124/294 (42%), Gaps = 23/294 (7%)
Frame = +1
Query: 1 EVESQLGSDDCGKDLNSVTNLQKKHNLLESDISS-HQDRIDSFLQQADQFVHDNHFDADA 177
E E+ L +DD G+DL+SV L K ++ + + Q+ I + DQ + H + A
Sbjct: 1999 EKENSLKTDDYGRDLSSVQTLLTKQETFDAGLQAFQQEGIANITALKDQLLAAKHIQSKA 2058
Query: 178 IKKKQIEVCNRYSKLQEPLEKRKNKLNDAYKLHQ--------FYRDADDEEDWIHEKEPI 333
I+ + + R+++L RK KL +A + + F + A W E
Sbjct: 2059 IEVRHASLMKRWNQLLANSAARKKKLLEAQEHFRKVEDLFLTFAKKASAFNSWFENAEED 2118
Query: 334 AGSTNVGRDLIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKM----IDGNHYANRDIE 501
L ++ L + H A ++ ++ + ++ +++ + N Y +E
Sbjct: 2119 LTDPVRCNSLEEIKALREAHDAFRSSLSSAQADFNQLAELDRQIKSFRVASNPYTWFTME 2178
Query: 502 KKIDDMKNLWSDLKNK-----ADKRRQLLDDSLEAQQYLADASEAESWMREKEP--LVGS 660
+ +NL +K + ++RRQ +D L Q++ A+ W++E L GS
Sbjct: 2179 ALEETWRNLQKIIKERELELQKEQRRQEENDKLR-QEFAQHANAFHQWIQETRTYLLDGS 2237
Query: 661 ---TEFGKDEDSTEALLKKHDALMADIEAYRSTIDSLRTQADACKMQEAPVSDS 813
E G E EA +KH +I A RS + + A M+EA + D+
Sbjct: 2238 CMVEESGTLESQLEATKRKHQ----EIRAMRSQLKKIEDLGAA--MEEALILDN 2285
>sp|P13395|SPTCA_DROME Spectrin alpha chain
Length = 2415
Score = 322 bits (825), Expect = 8e-88
Identities = 155/283 (54%), Positives = 210/283 (74%)
Frame = +1
Query: 1 EVESQLGSDDCGKDLNSVTNLQKKHNLLESDISSHQDRIDSFLQQADQFVHDNHFDADAI 180
E+E QL S+D GKDL SV NLQKKH LLE+D+ +HQDRI+S A++F+ HFDAD I
Sbjct: 699 EIEGQLLSEDHGKDLTSVQNLQKKHALLEADVMAHQDRIESIKVAANKFIESGHFDADNI 758
Query: 181 KKKQIEVCNRYSKLQEPLEKRKNKLNDAYKLHQFYRDADDEEDWIHEKEPIAGSTNVGRD 360
+ K+ + RY+ L P+ +RK L D+ ++ Q +RD +DE WI EKEPIA STN GRD
Sbjct: 759 RNKEGNLSARYAALAAPMGERKQHLLDSLQVQQLFRDLEDEAAWIREKEPIAASTNRGRD 818
Query: 361 LIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANRDIEKKIDDMKNLWSDL 540
LIGVQNLIKKHQA+ AE+ HE R+L V + G+ M+ +A+ DI ++++ ++ W+ L
Sbjct: 819 LIGVQNLIKKHQAVLAEINNHEARLLNVISSGENMLKDQPFASDDIRQRLEALQEQWNTL 878
Query: 541 KNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFGKDEDSTEALLKKHDAL 720
K K+ +R+Q LDDSL+A QY ADA+EAESWMREKEP+ +++GKDEDS+EALLKKH+AL
Sbjct: 879 KEKSSQRKQDLDDSLQAHQYFADANEAESWMREKEPIATGSDYGKDEDSSEALLKKHEAL 938
Query: 721 MADIEAYRSTIDSLRTQADACKMQEAPVSDSYGKETVMALYDY 849
++D+EA+ +TI +L+ QA C+ QE PV D GKE V+ALYDY
Sbjct: 939 VSDLEAFGNTIQALQEQAKNCRQQETPVVDITGKECVVALYDY 981
Score = 217 bits (552), Expect = 4e-56
Identities = 109/248 (43%), Positives = 156/248 (62%)
Frame = +1
Query: 1 EVESQLGSDDCGKDLNSVTNLQKKHNLLESDISSHQDRIDSFLQQADQFVHDNHFDADAI 180
EVES L ++D GKDL SV NL KKH L+E+DI +H+DRI QAD V FD I
Sbjct: 1624 EVESLLTTEDSGKDLASVQNLMKKHQLVEADIVAHEDRIKDMNNQADSLVESGQFDTAGI 1683
Query: 181 KKKQIEVCNRYSKLQEPLEKRKNKLNDAYKLHQFYRDADDEEDWIHEKEPIAGSTNVGRD 360
++K+ + RY ++ R+ +LN+A LHQF+RD DEE WI EK+ + GS + GRD
Sbjct: 1684 QEKRQSINERYERICNLAAHRQARLNEALTLHQFFRDIADEESWIKEKKLLVGSDDYGRD 1743
Query: 361 LIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANRDIEKKIDDMKNLWSDL 540
L GVQNL KKH+ ++AE+ HEP I V G+K++D ++ +IE+++ + W++L
Sbjct: 1744 LTGVQNLKKKHKRLEAELGSHEPAIQAVQEAGEKLMDVSNLGVPEIEQRLKALNQAWAEL 1803
Query: 541 KNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFGKDEDSTEALLKKHDAL 720
KN A R Q LD+SL QQ+LA E E+W+ EK+ L+ ++G + + LLKKHDA
Sbjct: 1804 KNLAATRGQKLDESLTYQQFLAQVEEEEAWITEKQQLLSVEDYGDSMAAVQGLLKKHDAF 1863
Query: 721 MADIEAYR 744
D A++
Sbjct: 1864 ETDFTAHK 1871
Score = 150 bits (380), Expect = 3e-36
Identities = 79/256 (30%), Positives = 142/256 (55%), Gaps = 2/256 (0%)
Frame = +1
Query: 1 EVESQLGSDDCGKDLNSVTNLQKKHNLLESDISSHQDRIDSFLQQADQF--VHDNHFDAD 174
E + L SDD G+DL SV LQ+KH +E D+++ +D++ + +A + +H +H +D
Sbjct: 276 EKDVVLSSDDYGRDLASVQALQRKHEGVERDLAALEDKVSTLGAEAQRLCSIHADH--SD 333
Query: 175 AIKKKQIEVCNRYSKLQEPLEKRKNKLNDAYKLHQFYRDADDEEDWIHEKEPIAGSTNVG 354
I+ KQ E+ N + L +RK KL+++Y LH+F D D WI+ + I + +
Sbjct: 334 QIRDKQAEIANYWQSLTTKARERKQKLDESYYLHRFLADFRDLVSWINGMKAIISADELA 393
Query: 355 RDLIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANRDIEKKIDDMKNLWS 534
+D+ G + L+++HQ + E+ E GQK+++ HYA +I++K+ ++N S
Sbjct: 394 KDVAGAEALLERHQEHKGEIDAREDSFKLTTESGQKLLEREHYAAAEIQEKLAALENDKS 453
Query: 535 DLKNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFGKDEDSTEALLKKHD 714
L + + RR L + ++ Q + D +A++WM ++E + + + G DS EAL+KKH+
Sbjct: 454 SLLSLWEDRRILYEQCMDLQLFYRDTEQADTWMAKQEAFLANEDLGDSLDSVEALIKKHE 513
Query: 715 ALMADIEAYRSTIDSL 762
+ A I +L
Sbjct: 514 DFEKSLAAQEEKIKAL 529
Score = 143 bits (361), Expect = 5e-34
Identities = 84/289 (29%), Positives = 156/289 (53%), Gaps = 9/289 (3%)
Frame = +1
Query: 7 ESQLGSDDCGKDLNSVTNLQKKHNLLESDISSHQDRIDSFLQQADQFVHDNHFDADAIKK 186
E+ + +D+ G+DL V LQ+K + + D++S + R+ Q AD+ V D H + D I K
Sbjct: 172 ETFVTADEFGQDLEHVEVLQRKFDEFQKDMASQEYRVTEVNQLADKLVQDGHPERDTITK 231
Query: 187 KQIEVCNRYSKLQEPLEKRKNKLNDAYKLHQFYRDADDEEDWIHEKEPIAGSTNVGRDLI 366
++ E+ + +L++ R+ KL A+++ +F RDAD+ WI EK+ + S + GRDL
Sbjct: 232 RKEELNEAWQRLKQLAIVRQEKLFGAHEIQRFNRDADETVAWIAEKDVVLSSDDYGRDLA 291
Query: 367 GVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANRDIEKKIDDMKNLWSDLKN 546
VQ L +KH+ ++ ++ E ++ + E Q++ + + I K ++ N W L
Sbjct: 292 SVQALQRKHEGVERDLAALEDKVSTLGAEAQRLCSIHADHSDQIRDKQAEIANYWQSLTT 351
Query: 547 KADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFGKDEDSTEALLKKHDALMA 726
KA +R+Q LD+S ++LAD + SW+ + ++ + E KD EALL++H
Sbjct: 352 KARERKQKLDESYYLHRFLADFRDLVSWINGMKAIISADELAKDVAGAEALLERHQEHKG 411
Query: 727 DIEA----YRSTIDS-----LRTQADACKMQEAPVSDSYGKETVMALYD 846
+I+A ++ T +S R A ++QE + K ++++L++
Sbjct: 412 EIDAREDSFKLTTESGQKLLEREHYAAAEIQEKLAALENDKSSLLSLWE 460
Score = 140 bits (353), Expect = 4e-33
Identities = 75/247 (30%), Positives = 130/247 (52%)
Frame = +1
Query: 13 QLGSDDCGKDLNSVTNLQKKHNLLESDISSHQDRIDSFLQQADQFVHDNHFDADAIKKKQ 192
+ +DD D ++ +KH E ++++++ RI+ + + H+ AD I +
Sbjct: 597 KFATDDSYLDPTNLNGKMQKHQNFEHELNANKSRIEDITNVGTELIEKQHYAADQINTRM 656
Query: 193 IEVCNRYSKLQEPLEKRKNKLNDAYKLHQFYRDADDEEDWIHEKEPIAGSTNVGRDLIGV 372
E+ + L + +K+ KLN+A + QF R +D E W+ E E S + G+DL V
Sbjct: 657 QEIVVLWETLVQASDKKGTKLNEACQQQQFNRTIEDIELWLSEIEGQLLSEDHGKDLTSV 716
Query: 373 QNLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANRDIEKKIDDMKNLWSDLKNKA 552
QNL KKH ++A+V H+ RI + K I+ H+ +I K ++ ++ L
Sbjct: 717 QNLQKKHALLEADVMAHQDRIESIKVAANKFIESGHFDADNIRNKEGNLSARYAALAAPM 776
Query: 553 DKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFGKDEDSTEALLKKHDALMADI 732
+R+Q L DSL+ QQ D + +W+REKEP+ ST G+D + L+KKH A++A+I
Sbjct: 777 GERKQHLLDSLQVQQLFRDLEDEAAWIREKEPIAASTNRGRDLIGVQNLIKKHQAVLAEI 836
Query: 733 EAYRSTI 753
+ + +
Sbjct: 837 NNHEARL 843
Score = 139 bits (351), Expect = 8e-33
Identities = 79/259 (30%), Positives = 134/259 (51%)
Frame = +1
Query: 1 EVESQLGSDDCGKDLNSVTNLQKKHNLLESDISSHQDRIDSFLQQADQFVHDNHFDADAI 180
E + L +DD GKDL SV LQ+KH +E D+++ +D+I + A++ + + A+
Sbjct: 1199 EKANALNNDDLGKDLRSVQTLQRKHEGVERDLAALRDKIRQLDETANRLMQSHPDTAEQT 1258
Query: 181 KKKQIEVCNRYSKLQEPLEKRKNKLNDAYKLHQFYRDADDEEDWIHEKEPIAGSTNVGRD 360
KQ E+ + ++ RK KL D+Y L +F D D WI+ + S + D
Sbjct: 1259 YAKQKEINEMWDQIITKSTARKEKLLDSYDLQRFLSDYRDLLAWINSMMSLVTSDELAND 1318
Query: 361 LIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANRDIEKKIDDMKNLWSDL 540
+ G + LI++HQ + E+ G +++ NHYA+ +I++KI+D+ DL
Sbjct: 1319 VTGAEALIERHQEHRTEIDARAGTFGAFEQFGNELLQANHYASPEIKEKIEDLAKAREDL 1378
Query: 541 KNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFGKDEDSTEALLKKHDAL 720
+ +RR L+ +L+ Q Y+ D AESWM +E + + + + EAL+KKH+
Sbjct: 1379 EKAWTERRLQLEQNLDLQLYMRDCELAESWMSAREAFLNADDDANAGGNVEALIKKHEDF 1438
Query: 721 MADIEAYRSTIDSLRTQAD 777
I + I +L+T AD
Sbjct: 1439 DKAINGHEQKIAALQTVAD 1457
Score = 139 bits (351), Expect = 8e-33
Identities = 79/260 (30%), Positives = 142/260 (54%), Gaps = 2/260 (0%)
Frame = +1
Query: 7 ESQLGSDDCGKDLNSVTNLQKKHNLLESDISSHQDRIDSFLQQADQFVHDNHFDADAIKK 186
E+ L +DD +V L KKH + I+ H+ +I + ADQ + NH+ ++ + +
Sbjct: 1413 EAFLNADDDANAGGNVEALIKKHEDFDKAINGHEQKIAALQTVADQLIAQNHYASNLVDE 1472
Query: 187 KQIEVCNRYSKLQEPLEKRKNKLNDAYKLHQFYRDADDEEDWIHEKEPIAGSTNVGRDLI 366
K+ +V R+ L+E L +++++L D L QF RDAD+ E+WI EK +A + +D
Sbjct: 1473 KRKQVLERWRHLKEGLIEKRSRLGDEQTLQQFSRDADEIENWIAEKLQLATEESY-KDPA 1531
Query: 367 GVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANRD--IEKKIDDMKNLWSDL 540
+Q+ +KHQA +AE+ + RI V G +ID + + ++K++ + + W L
Sbjct: 1532 NIQSKHQKHQAFEAELAANADRIQSVLAMGGNLIDKKQCSGSEDAVQKRLTQIADQWEYL 1591
Query: 541 KNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFGKDEDSTEALLKKHDAL 720
+K ++ L ++ + + Y+A + + W+ E E L+ + + GKD S + L+KKH +
Sbjct: 1592 THKTTEKSLKLKEANKQRTYIAAVKDLDFWLGEVESLLTTEDSGKDLASVQNLMKKHQLV 1651
Query: 721 MADIEAYRSTIDSLRTQADA 780
ADI A+ I + QAD+
Sbjct: 1652 EADIVAHEDRIKDMNNQADS 1671
Score = 138 bits (348), Expect = 2e-32
Identities = 68/253 (26%), Positives = 138/253 (54%), Gaps = 2/253 (0%)
Frame = +1
Query: 13 QLGSDDCGKDLNSVTNLQKKHNLLESDISSHQDRIDSFLQQADQFVHDNHFDA--DAIKK 186
QL +++ KD ++ + +KH E++++++ DRI S L + DA++K
Sbjct: 1520 QLATEESYKDPANIQSKHQKHQAFEAELAANADRIQSVLAMGGNLIDKKQCSGSEDAVQK 1579
Query: 187 KQIEVCNRYSKLQEPLEKRKNKLNDAYKLHQFYRDADDEEDWIHEKEPIAGSTNVGRDLI 366
+ ++ +++ L ++ KL +A K + D + W+ E E + + + G+DL
Sbjct: 1580 RLTQIADQWEYLTHKTTEKSLKLKEANKQRTYIAAVKDLDFWLGEVESLLTTEDSGKDLA 1639
Query: 367 GVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANRDIEKKIDDMKNLWSDLKN 546
VQNL+KKHQ ++A++ HE RI ++ N+ +++ + I++K + + + N
Sbjct: 1640 SVQNLMKKHQLVEADIVAHEDRIKDMNNQADSLVESGQFDTAGIQEKRQSINERYERICN 1699
Query: 547 KADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFGKDEDSTEALLKKHDALMA 726
A R+ L+++L Q+ D ++ ESW++EK+ LVGS ++G+D + L KKH L A
Sbjct: 1700 LAAHRQARLNEALTLHQFFRDIADEESWIKEKKLLVGSDDYGRDLTGVQNLKKKHKRLEA 1759
Query: 727 DIEAYRSTIDSLR 765
++ ++ I +++
Sbjct: 1760 ELGSHEPAIQAVQ 1772
Score = 137 bits (344), Expect = 5e-32
Identities = 77/257 (29%), Positives = 138/257 (53%)
Frame = +1
Query: 7 ESQLGSDDCGKDLNSVTNLQKKHNLLESDISSHQDRIDSFLQQADQFVHDNHFDADAIKK 186
E+ L ++D G L+SV L KKH E +++ +++I + A + + H+ AD + +
Sbjct: 490 EAFLANEDLGDSLDSVEALIKKHEDFEKSLAAQEEKIKALDIFATKLIDGQHYAADDVAQ 549
Query: 187 KQIEVCNRYSKLQEPLEKRKNKLNDAYKLHQFYRDADDEEDWIHEKEPIAGSTNVGRDLI 366
++ + R + LQE KR+ L D+ + QF RD D+ + WI EK A + D
Sbjct: 550 RRQMLLARRAALQEKSSKRRQLLEDSNRYQQFERDCDETKGWISEKLKFATDDSY-LDPT 608
Query: 367 GVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANRDIEKKIDDMKNLWSDLKN 546
+ ++KHQ + E+ ++ RI ++ N G ++I+ HYA I ++ ++ LW L
Sbjct: 609 NLNGKMQKHQNFEHELNANKSRIEDITNVGTELIEKQHYAADQINTRMQEIVVLWETLVQ 668
Query: 547 KADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFGKDEDSTEALLKKHDALMA 726
+DK+ L+++ + QQ+ + E W+ E E + S + GKD S + L KKH L A
Sbjct: 669 ASDKKGTKLNEACQQQQFNRTIEDIELWLSEIEGQLLSEDHGKDLTSVQNLQKKHALLEA 728
Query: 727 DIEAYRSTIDSLRTQAD 777
D+ A++ I+S++ A+
Sbjct: 729 DVMAHQDRIESIKVAAN 745
Score = 136 bits (342), Expect = 8e-32
Identities = 68/242 (28%), Positives = 130/242 (53%)
Frame = +1
Query: 16 LGSDDCGKDLNSVTNLQKKHNLLESDISSHQDRIDSFLQQADQFVHDNHFDADAIKKKQI 195
+GSDD G+DL V NL+KKH LE+++ SH+ I + + ++ + ++ I+++
Sbjct: 1735 VGSDDYGRDLTGVQNLKKKHKRLEAELGSHEPAIQAVQEAGEKLMDVSNLGVPEIEQRLK 1794
Query: 196 EVCNRYSKLQEPLEKRKNKLNDAYKLHQFYRDADDEEDWIHEKEPIAGSTNVGRDLIGVQ 375
+ +++L+ R KL+++ QF ++EE WI EK+ + + G + VQ
Sbjct: 1795 ALNQAWAELKNLAATRGQKLDESLTYQQFLAQVEEEEAWITEKQQLLSVEDYGDSMAAVQ 1854
Query: 376 NLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANRDIEKKIDDMKNLWSDLKNKAD 555
L+KKH A + + T H+ R +C++G ++++ ++ I ++ ++ +L A
Sbjct: 1855 GLLKKHDAFETDFTAHKDRCSLICDQGSELVEAKNHHGESIAQRCQQLRLKLDNLSALAA 1914
Query: 556 KRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFGKDEDSTEALLKKHDALMADIE 735
+R+ L D+ Q++ A ESW+ +KE V S EFG+D + + LL K + A +
Sbjct: 1915 RRKGALLDNSAYLQFMWKADVVESWIDDKENYVRSDEFGRDLSTVQTLLTKQETFDAGLN 1974
Query: 736 AY 741
A+
Sbjct: 1975 AF 1976
Score = 126 bits (316), Expect = 9e-29
Identities = 67/215 (31%), Positives = 115/215 (53%)
Frame = +1
Query: 178 IKKKQIEVCNRYSKLQEPLEKRKNKLNDAYKLHQFYRDADDEEDWIHEKEPIAGSTNVGR 357
I++++ +V +RY+ + +++ KL D+ + F RDAD+ E WIHEK A + R
Sbjct: 18 IQERREQVLSRYNDFKIETRQKREKLEDSRRFQYFKRDADELESWIHEKLQAASEESY-R 76
Query: 358 DLIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANRDIEKKIDDMKNLWSD 537
D +Q I+KHQA +AEV+ H I+ + N GQ+MI+ H+A+ I+ ++D++ LW
Sbjct: 77 DPTNLQAKIQKHQAFEAEVSAHSNAIVSLDNTGQEMINQQHFASESIQVRLDELHKLWEL 136
Query: 538 LKNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFGKDEDSTEALLKKHDA 717
L ++ ++ L +L Q+L E W+++KE V + EFG+D + E L +K D
Sbjct: 137 LLSRLAEKGLKLQQALVLVQFLRQCEEVMFWIKDKETFVTADEFGQDLEHVEVLQRKFDE 196
Query: 718 LMADIEAYRSTIDSLRTQADACKMQEAPVSDSYGK 822
D+ + + + AD P D+ K
Sbjct: 197 FQKDMASQEYRVTEVNQLADKLVQDGHPERDTITK 231
Score = 122 bits (306), Expect = 1e-27
Identities = 71/266 (26%), Positives = 131/266 (49%)
Frame = +1
Query: 13 QLGSDDCGKDLNSVTNLQKKHNLLESDISSHQDRIDSFLQQADQFVHDNHFDADAIKKKQ 192
Q S++ +D ++ +KH E+++S+H + I S + ++ HF +++I+ +
Sbjct: 68 QAASEESYRDPTNLQAKIQKHQAFEAEVSAHSNAIVSLDNTGQEMINQQHFASESIQVRL 127
Query: 193 IEVCNRYSKLQEPLEKRKNKLNDAYKLHQFYRDADDEEDWIHEKEPIAGSTNVGRDLIGV 372
E+ + L L ++ KL A L QF R ++ WI +KE + G+DL V
Sbjct: 128 DELHKLWELLLSRLAEKGLKLQQALVLVQFLRQCEEVMFWIKDKETFVTADEFGQDLEHV 187
Query: 373 QNLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANRDIEKKIDDMKNLWSDLKNKA 552
+ L +K Q ++ E R+ EV K++ H I K+ +++ W LK A
Sbjct: 188 EVLQRKFDEFQKDMASQEYRVTEVNQLADKLVQDGHPERDTITKRKEELNEAWQRLKQLA 247
Query: 553 DKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFGKDEDSTEALLKKHDALMADI 732
R++ L + E Q++ DA E +W+ EK+ ++ S ++G+D S +AL +KH+ + D+
Sbjct: 248 IVRQEKLFGAHEIQRFNRDADETVAWIAEKDVVLSSDDYGRDLASVQALQRKHEGVERDL 307
Query: 733 EAYRSTIDSLRTQADACKMQEAPVSD 810
A + +L +A A SD
Sbjct: 308 AALEDKVSTLGAEAQRLCSIHADHSD 333
Score = 109 bits (273), Expect = 8e-24
Identities = 61/244 (25%), Positives = 125/244 (51%), Gaps = 1/244 (0%)
Frame = +1
Query: 22 SDDCGKDLNSVTNLQKKHNLLESDISSHQDRIDSFLQQADQFVHDNHFDADAIKKKQIEV 201
+D G+DL V LQKK + D+ +++ R+ + + A Q +A + Q++
Sbjct: 1099 ADVVGEDLEEVEVLQKKFDDFNDDLKANEVRLANMNEIAVQLTSLGQTEAALKIQTQMQD 1158
Query: 202 CN-RYSKLQEPLEKRKNKLNDAYKLHQFYRDADDEEDWIHEKEPIAGSTNVGRDLIGVQN 378
N +++ LQ ++ ++L A+++ +F+RD D+ +DWI EK + ++G+DL VQ
Sbjct: 1159 LNEKWNNLQTLTAEKASQLGSAHEVQRFHRDIDETKDWIAEKANALNNDDLGKDLRSVQT 1218
Query: 379 LIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANRDIEKKIDDMKNLWSDLKNKADK 558
L +KH+ ++ ++ +I ++ +++ + K ++ +W + K+
Sbjct: 1219 LQRKHEGVERDLAALRDKIRQLDETANRLMQSHPDTAEQTYAKQKEINEMWDQIITKSTA 1278
Query: 559 RRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFGKDEDSTEALLKKHDALMADIEA 738
R++ L DS + Q++L+D + +W+ LV S E D EAL+++H +I+A
Sbjct: 1279 RKEKLLDSYDLQRFLSDYRDLLAWINSMMSLVTSDELANDVTGAEALIERHQEHRTEIDA 1338
Query: 739 YRST 750
T
Sbjct: 1339 RAGT 1342
Score = 108 bits (271), Expect = 1e-23
Identities = 64/249 (25%), Positives = 117/249 (46%)
Frame = +1
Query: 16 LGSDDCGKDLNSVTNLQKKHNLLESDISSHQDRIDSFLQQADQFVHDNHFDADAIKKKQI 195
+ +D+ KD+ L ++H + +I + +D + + + H+ A I++K
Sbjct: 387 ISADELAKDVAGAEALLERHQEHKGEIDAREDSFKLTTESGQKLLEREHYAAAEIQEKLA 446
Query: 196 EVCNRYSKLQEPLEKRKNKLNDAYKLHQFYRDADDEEDWIHEKEPIAGSTNVGRDLIGVQ 375
+ N S L E R+ L FYRD + + W+ ++E + ++G L V+
Sbjct: 447 ALENDKSSLLSLWEDRRILYEQCMDLQLFYRDTEQADTWMAKQEAFLANEDLGDSLDSVE 506
Query: 376 NLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANRDIEKKIDDMKNLWSDLKNKAD 555
LIKKH+ + + E +I + K+IDG HYA D+ ++ + + L+ K+
Sbjct: 507 ALIKKHEDFEKSLAAQEEKIKALDIFATKLIDGQHYAADDVAQRRQMLLARRAALQEKSS 566
Query: 556 KRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFGKDEDSTEALLKKHDALMADIE 735
KRRQLL+DS QQ+ D E + W+ EK + D + ++KH ++
Sbjct: 567 KRRQLLEDSNRYQQFERDCDETKGWISEKLKFATDDSY-LDPTNLNGKMQKHQNFEHELN 625
Query: 736 AYRSTIDSL 762
A +S I+ +
Sbjct: 626 ANKSRIEDI 634
Score = 105 bits (263), Expect = 1e-22
Identities = 65/251 (25%), Positives = 118/251 (47%)
Frame = +1
Query: 10 SQLGSDDCGKDLNSVTNLQKKHNLLESDISSHQDRIDSFLQQADQFVHDNHFDADAIKKK 189
S + SD+ D+ L ++H ++I + +F Q ++ + NH+ + IK+K
Sbjct: 1308 SLVTSDELANDVTGAEALIERHQEHRTEIDARAGTFGAFEQFGNELLQANHYASPEIKEK 1367
Query: 190 QIEVCNRYSKLQEPLEKRKNKLNDAYKLHQFYRDADDEEDWIHEKEPIAGSTNVGRDLIG 369
++ L++ +R+ +L L + RD + E W+ +E + +
Sbjct: 1368 IEDLAKAREDLEKAWTERRLQLEQNLDLQLYMRDCELAESWMSAREAFLNADDDANAGGN 1427
Query: 370 VQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANRDIEKKIDDMKNLWSDLKNK 549
V+ LIKKH+ + GHE +I + ++I NHYA+ +++K + W LK
Sbjct: 1428 VEALIKKHEDFDKAINGHEQKIAALQTVADQLIAQNHYASNLVDEKRKQVLERWRHLKEG 1487
Query: 550 ADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFGKDEDSTEALLKKHDALMAD 729
++R L D QQ+ DA E E+W+ EK L + E KD + ++ +KH A A+
Sbjct: 1488 LIEKRSRLGDEQTLQQFSRDADEIENWIAEKLQL-ATEESYKDPANIQSKHQKHQAFEAE 1546
Query: 730 IEAYRSTIDSL 762
+ A I S+
Sbjct: 1547 LAANADRIQSV 1557
Score = 97.8 bits (242), Expect = 3e-20
Identities = 68/242 (28%), Positives = 118/242 (48%), Gaps = 4/242 (1%)
Frame = +1
Query: 112 RIDSFLQQADQFVHDNHFDADAIKKKQIEVCNRYSKLQEPLEKRKNKLNDAYKLHQFYRD 291
+ID+ L + Q + DNH +I K+Q ++ ++Y L +R+NKLN+ K + R+
Sbjct: 1026 KIDAGLSASQQNLVDNH----SIAKRQNQINSQYDNLLALARERQNKLNETVKAYVLVRE 1081
Query: 292 ADDEEDWIHEKEPIAGSTNV-GRDLIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMI 468
A D WI +KE A +V G DL V+ L KK ++ +E R+ + ++
Sbjct: 1082 AADLAQWIRDKENHAQIADVVGEDLEEVEVLQKKFDDFNDDLKANEVRLANMNEIAVQLT 1141
Query: 469 D-GNHYANRDIEKKIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYLADASEAESWMREKE 645
G A I+ ++ D+ W++L+ ++ L + E Q++ D E + W+ EK
Sbjct: 1142 SLGQTEAALKIQTQMQDLNEKWNNLQTLTAEKASQLGSAHEVQRFHRDIDETKDWIAEKA 1201
Query: 646 PLVGSTEFGKDEDSTEALLKKHDALMADIEAYRSTIDSLRTQADACKMQEAP--VSDSYG 819
+ + + GKD S + L +KH+ + D+ A R I L A+ MQ P +Y
Sbjct: 1202 NALNNDDLGKDLRSVQTLQRKHEGVERDLAALRDKIRQLDETANRL-MQSHPDTAEQTYA 1260
Query: 820 KE 825
K+
Sbjct: 1261 KQ 1262
Score = 80.9 bits (198), Expect = 4e-15
Identities = 60/232 (25%), Positives = 100/232 (43%), Gaps = 1/232 (0%)
Frame = +1
Query: 1 EVESQLGSDDCGKDLNSVTNLQKKHNLLESDISSHQDRIDSFLQQADQFVHDNHFDADAI 180
E + L +D G + +V L KKH+ E+D ++H+DR Q + V + ++I
Sbjct: 1836 EKQQLLSVEDYGDSMAAVQGLLKKHDAFETDFTAHKDRCSLICDQGSELVEAKNHHGESI 1895
Query: 181 KKKQIEVCNRYSKLQEPLEKRKNKLNDAYKLHQFYRDADDEEDWIHEKEPIAGSTNVGRD 360
++ ++ + L +RK L D QF AD E WI +KE S GRD
Sbjct: 1896 AQRCQQLRLKLDNLSALAARRKGALLDNSAYLQFMWKADVVESWIDDKENYVRSDEFGRD 1955
Query: 361 LIGVQNLIKKHQAIQAEVTGHEPR-ILEVCNEGQKMIDGNHYANRDIEKKIDDMKNLWSD 537
L VQ L+ K + A + E I + ++I+ +H + I K+ D+ W
Sbjct: 1956 LSTVQTLLTKQETFDAGLNAFEQEGIHNITALKDQLINASHAQSPAILKRHGDVIARWQK 2015
Query: 538 LKNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFGKDEDSTE 693
L++ ++ R+ D L Q+ E +K S +ED T+
Sbjct: 2016 LRDASNTRK---DRLLAMQEQFRQIEELYLTFAKKASAFNSWFENAEEDLTD 2064
Score = 55.1 bits (131), Expect = 2e-07
Identities = 32/107 (29%), Positives = 58/107 (54%)
Frame = +1
Query: 493 DIEKKIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFG 672
DI+++ + + + ++D K + ++R+ L+DS Q + DA E ESW+ EK S E
Sbjct: 17 DIQERREQVLSRYNDFKIETRQKREKLEDSRRFQYFKRDADELESWIHEKLQ-AASEESY 75
Query: 673 KDEDSTEALLKKHDALMADIEAYRSTIDSLRTQADACKMQEAPVSDS 813
+D + +A ++KH A A++ A+ + I SL Q+ S+S
Sbjct: 76 RDPTNLQAKIQKHQAFEAEVSAHSNAIVSLDNTGQEMINQQHFASES 122
>sp|P08032|SPTA1_MOUSE Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin)
Length = 2415
Score = 246 bits (628), Expect = 6e-65
Identities = 120/285 (42%), Positives = 184/285 (64%), Gaps = 1/285 (0%)
Frame = +1
Query: 1 EVESQLGSDDCGKDLNSVTNLQKKHNLLESDISSHQDRIDSFLQQADQFVHDNHFDADAI 180
EVE Q+ S+D GK L V NL +KH LLESD+++ Q+++D+ A F H D+ I
Sbjct: 703 EVEWQVTSEDYGKVLADVQNLLRKHGLLESDVTARQNQMDTLTDMAAHFEEIGHPDSGDI 762
Query: 181 KKKQIEVCNRYSKLQEPLEKRKNKLNDAYKLHQFYRDADDEEDWIHEKEPIAGSTNVGRD 360
+ +Q + +R+ L+EPL RK KL D KL Q RD++DEE WI E EP A ST++G+D
Sbjct: 763 RARQESLLSRFEALKEPLAIRKKKLIDLLKLQQICRDSEDEEAWIQETEPSAASTHLGKD 822
Query: 361 LIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANRDIEKKIDDMKNLWSDL 540
L+ +NL+ +H+ I A++ HEPRI + G KM++ H+A DI +++ + L
Sbjct: 823 LVAAKNLLNRHEVILADIASHEPRIQVITERGNKMVEEGHFAAEDIASRVESLNKNMESL 882
Query: 541 KNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFGKDEDSTEALLKKHDAL 720
+A +R L +++ QQYLAD EAE+W++EKEP+V + +G DE++ ALLKKH+A
Sbjct: 883 HARAIRRENDLKANVQLQQYLADLHEAEAWIKEKEPIVDNKNYGADEEAAGALLKKHEAF 942
Query: 721 MADIEAYRSTIDSLRTQADACKMQEAPVSDSYGKET-VMALYDYQ 852
+ D+ A+ ++I +LR QA+ C+ Q+A D G+E V+ALYD++
Sbjct: 943 LVDLNAFENSIKALRDQAEVCQQQQAAPVDEAGREARVIALYDFE 987
Score = 163 bits (413), Expect = 5e-40
Identities = 87/259 (33%), Positives = 137/259 (52%)
Frame = +1
Query: 1 EVESQLGSDDCGKDLNSVTNLQKKHNLLESDISSHQDRIDSFLQQADQFVHDNHFDADAI 180
E E L D +DL S NL KKH LLE+++ + +D + A + + F+ D I
Sbjct: 1623 EAEGLLAMKDQARDLTSAGNLLKKHQLLEAEMLAREDPLKDLNDLAQELISSGTFNIDQI 1682
Query: 181 KKKQIEVCNRYSKLQEPLEKRKNKLNDAYKLHQFYRDADDEEDWIHEKEPIAGSTNVGRD 360
++K V R+ +Q KL + Y L QF++D DDEE WI EK S + GRD
Sbjct: 1683 EEKMNGVNERFENVQSLAAAHHEKLKETYALFQFFQDLDDEEAWIEEKLLRVSSQDYGRD 1742
Query: 361 LIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANRDIEKKIDDMKNLWSDL 540
L VQNL+KKH+ ++ E+ HEP + V + + + D +I++++ W L
Sbjct: 1743 LQSVQNLLKKHKRLEGELVAHEPAVQNVLDTAESLRDKAAVGKEEIQERLAQFVQHWEKL 1802
Query: 541 KNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFGKDEDSTEALLKKHDAL 720
K A R L++SLE Q++ +A E E+W+ EK LV + G +T++LLKKH+AL
Sbjct: 1803 KELAKTRGVNLEESLEYLQFMENAEEEEAWLGEKCALVSRGDSGDTLAATQSLLKKHEAL 1862
Query: 721 MADIEAYRSTIDSLRTQAD 777
D +++ + + Q +
Sbjct: 1863 ENDFAVHKNRVQDVCAQGE 1881
Score = 129 bits (324), Expect = 1e-29
Identities = 77/282 (27%), Positives = 139/282 (49%)
Frame = +1
Query: 1 EVESQLGSDDCGKDLNSVTNLQKKHNLLESDISSHQDRIDSFLQQADQFVHDNHFDADAI 180
E E QL S+D GKDL S L H LE +++ D++ +AD+ + + DA I
Sbjct: 280 EKEPQLTSEDYGKDLVSSEALFHNHKRLERNLAVMDDKVKELCAKADKLMISHSADALQI 339
Query: 181 KKKQIEVCNRYSKLQEPLEKRKNKLNDAYKLHQFYRDADDEEDWIHEKEPIAGSTNVGRD 360
++ ++++ + + +++ R KL +Y H+F D D+ W+ EK + + + D
Sbjct: 340 QQMKLDLVSNWERIRALATNRYAKLKASYGYHRFLSDYDELSGWMKEKTALINADELPTD 399
Query: 361 LIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANRDIEKKIDDMKNLWSDL 540
+ + L+ +HQ + E+ ++ R GQ+++DGNH A+ +I +K+ + N W+ L
Sbjct: 400 VASGEALLARHQQHKHEIDSYDDRFQSADATGQELLDGNHEASEEIREKMTILANDWAAL 459
Query: 541 KNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFGKDEDSTEALLKKHDAL 720
DK + L+ + D+ + +SWM +E + + + G S EALL+KHD
Sbjct: 460 LELWDKCQHQYRQCLDFHLFYRDSEQVDSWMSRQEAFLENEDLGNSVGSVEALLQKHDDF 519
Query: 721 MADIEAYRSTIDSLRTQADACKMQEAPVSDSYGKETVMALYD 846
A I +L A K+ + +D Y E + A+ D
Sbjct: 520 EEAFTAQEEKIITL--DETATKLID---NDHYDSENIAAIRD 556
Score = 124 bits (311), Expect = 3e-28
Identities = 77/267 (28%), Positives = 135/267 (50%), Gaps = 5/267 (1%)
Frame = +1
Query: 13 QLGSDDCGKDLNSVTNLQKKHNLLESDISSHQDRIDSFLQQADQFVHDNHFDADAIKKKQ 192
++ S D G+DL SV NL KKH LE ++ +H+ + + L A+ + I+++
Sbjct: 1733 RVSSQDYGRDLQSVQNLLKKHKRLEGELVAHEPAVQNVLDTAESLRDKAAVGKEEIQERL 1792
Query: 193 IEVCNRYSKLQEPLEKRKNKLNDAYKLHQFYRDADDEEDWIHEKEPIAGSTNVGRDLIGV 372
+ + KL+E + R L ++ + QF +A++EE W+ EK + + G L
Sbjct: 1793 AQFVQHWEKLKELAKTRGVNLEESLEYLQFMENAEEEEAWLGEKCALVSRGDSGDTLAAT 1852
Query: 373 QNLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANRD-IEKKIDDMKNLWSDLKNK 549
Q+L+KKH+A++ + H+ R+ +VC +G+ +++ N+D I KI + + L
Sbjct: 1853 QSLLKKHEALENDFAVHKNRVQDVCAQGEDILNKEETQNKDKISTKIQVLNEKTASLAKA 1912
Query: 550 ADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFGKDEDSTEALLKKHDALMAD 729
+ LDD QQ+ A ESW+ EKE + + G D + LL KHD L A
Sbjct: 1913 LAAWKSQLDDVHAFQQFNWKADVVESWIGEKEASLKTKSNGADLTAFLTLLAKHDTLDAS 1972
Query: 730 IEAYR----STIDSLRTQADACKMQEA 798
+++++ S I L+ Q A + +A
Sbjct: 1973 LQSFQQERLSEIAELKDQLVAGEHSQA 1999
Score = 121 bits (304), Expect = 2e-27
Identities = 67/256 (26%), Positives = 141/256 (55%)
Frame = +1
Query: 7 ESQLGSDDCGKDLNSVTNLQKKHNLLESDISSHQDRIDSFLQQADQFVHDNHFDADAIKK 186
E+ L ++D G + SV L +KH+ E ++ +++I + + A + + ++H+D++ I
Sbjct: 494 EAFLENEDLGNSVGSVEALLQKHDDFEEAFTAQEEKIITLDETATKLIDNDHYDSENIAA 553
Query: 187 KQIEVCNRYSKLQEPLEKRKNKLNDAYKLHQFYRDADDEEDWIHEKEPIAGSTNVGRDLI 366
+ + R L+E R+ L D+ L Q Y+D+DD + WI++K+ +A + +D+
Sbjct: 554 IRDGLLARRDALRERAATRRKLLVDSQLLQQLYQDSDDLKTWINKKKKLADDDDY-KDVQ 612
Query: 367 GVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANRDIEKKIDDMKNLWSDLKN 546
+++ ++K Q + E+ +E + + GQ+MI+ HYA+ + ++ ++ NLW +L
Sbjct: 613 NLKSRVQKQQDFEEELAVNEIMLNNLEKTGQEMIEDGHYASEAVAARLSEVANLWKELLE 672
Query: 547 KADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFGKDEDSTEALLKKHDALMA 726
++ L ++ + Q+ +A + + W+ E E V S ++GK + LL+KH L +
Sbjct: 673 ATAQKGTQLYEANQLLQFENNAEDLKRWLEEVEWQVTSEDYGKVLADVQNLLRKHGLLES 732
Query: 727 DIEAYRSTIDSLRTQA 774
D+ A ++ +D+L A
Sbjct: 733 DVTARQNQMDTLTDMA 748
Score = 121 bits (303), Expect = 3e-27
Identities = 65/249 (26%), Positives = 135/249 (54%)
Frame = +1
Query: 7 ESQLGSDDCGKDLNSVTNLQKKHNLLESDISSHQDRIDSFLQQADQFVHDNHFDADAIKK 186
+ +L DD KD+ ++ + +K E +++ ++ +++ + + + D H+ ++A+
Sbjct: 599 KKKLADDDDYKDVQNLKSRVQKQQDFEEELAVNEIMLNNLEKTGQEMIEDGHYASEAVAA 658
Query: 187 KQIEVCNRYSKLQEPLEKRKNKLNDAYKLHQFYRDADDEEDWIHEKEPIAGSTNVGRDLI 366
+ EV N + +L E ++ +L +A +L QF +A+D + W+ E E S + G+ L
Sbjct: 659 RLSEVANLWKELLEATAQKGTQLYEANQLLQFENNAEDLKRWLEEVEWQVTSEDYGKVLA 718
Query: 367 GVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANRDIEKKIDDMKNLWSDLKN 546
VQNL++KH ++++VT + ++ + + + H + DI + + + + + LK
Sbjct: 719 DVQNLLRKHGLLESDVTARQNQMDTLTDMAAHFEEIGHPDSGDIRARQESLLSRFEALKE 778
Query: 547 KADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFGKDEDSTEALLKKHDALMA 726
R++ L D L+ QQ D+ + E+W++E EP ST GKD + + LL +H+ ++A
Sbjct: 779 PLAIRKKKLIDLLKLQQICRDSEDEEAWIQETEPSAASTHLGKDLVAAKNLLNRHEVILA 838
Query: 727 DIEAYRSTI 753
DI ++ I
Sbjct: 839 DIASHEPRI 847
Score = 117 bits (293), Expect = 4e-26
Identities = 76/275 (27%), Positives = 133/275 (48%), Gaps = 1/275 (0%)
Frame = +1
Query: 16 LGSDDCGKDLNSVTNLQKKHNLLESDISSHQDRIDSFLQQADQFVHDNHFDADAIKKKQI 195
L + D G DL SV LQ++H E DI +++++ + A++ + + ++K++
Sbjct: 1204 LNAADPGSDLLSVQALQRQHECFERDIIPLGEKVNTLGETAERLCESHPDATEDLQKQRT 1263
Query: 196 EVCNRYSKLQEPLEKRKNKLNDAYKLHQFYRDADDEEDWIHEKEPIAGSTNVGRDLIGVQ 375
E+ + LQ RK LN+A+K F A D E+WI + S + DL G +
Sbjct: 1264 ELNEAWDTLQGLTSDRKESLNEAHKFFLFLSKASDLENWIKTIGGVISSPELAEDLTGTE 1323
Query: 376 NLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANRDIEKKIDDMKNLWSDLKNKAD 555
L+++HQ ++ +P + + G ++ID H R+I+ + ++ + +L+ +
Sbjct: 1324 ILLERHQEHHDDIKREDPTFQALEDFGTELIDSGHRNRREIDNTLQNINSKRDNLEKSWE 1383
Query: 556 KRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFGKDE-DSTEALLKKHDALMADI 732
R+++LD LE Q + + ESWM +E + S + +D DS +AL+KK D L I
Sbjct: 1384 NRKKMLDQCLELQLFRGKCDQVESWMVARENSLRSDD--RDHLDSLQALMKKRDDLDKAI 1441
Query: 733 EAYRSTIDSLRTQADACKMQEAPVSDSYGKETVMA 837
A I L A +D Y KE + A
Sbjct: 1442 TAQEGKISDLENVA-----TRLIDNDHYAKEEIAA 1471
Score = 114 bits (284), Expect = 4e-25
Identities = 77/261 (29%), Positives = 129/261 (49%), Gaps = 5/261 (1%)
Frame = +1
Query: 7 ESQLGSDDCGKDLNSVTNLQKKHNLLESDISSHQDRIDSFLQQADQFVHDNHFDADAIKK 186
E+ L SDD L+S+ L KK + L+ I++ + +I A + + ++H+ + I
Sbjct: 1413 ENSLRSDD-RDHLDSLQALMKKRDDLDKAITAQEGKISDLENVATRLIDNDHYAKEEIAA 1471
Query: 187 KQIEVCNRYSKLQEPLEKRKNKLNDAYKLHQFYRDADDEEDWIHEKEPIAGSTNVGRDLI 366
+ V +R+ L+E L KL D L QFYRD +D E+WI+E PIA + +D
Sbjct: 1472 RLQRVLDRWKALKEQLLTELGKLGDYADLKQFYRDLEDLEEWINEMLPIACDESY-KDPT 1530
Query: 367 GVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMI-----DGNHYANRDIEKKIDDMKNLW 531
+Q KHQA + EV G ++ V N G +I DG+ ++++++D +K W
Sbjct: 1531 NIQRKYLKHQAFENEVNGRAEQVDGVINLGNSLIERRVCDGD---EENMQEQLDMLKENW 1587
Query: 532 SDLKNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFGKDEDSTEALLKKH 711
L + + Q L+++ Q++ + E W+ E E L+ + +D S LLKKH
Sbjct: 1588 DYLLERTTDKGQKLNEASRQQRFNTSIRDFEFWLSEAEGLLAMKDQARDLTSAGNLLKKH 1647
Query: 712 DALMADIEAYRSTIDSLRTQA 774
L A++ A + L A
Sbjct: 1648 QLLEAEMLAREDPLKDLNDLA 1668
Score = 111 bits (277), Expect = 3e-24
Identities = 64/244 (26%), Positives = 117/244 (47%)
Frame = +1
Query: 28 DCGKDLNSVTNLQKKHNLLESDISSHQDRIDSFLQQADQFVHDNHFDADAIKKKQIEVCN 207
+ G D L KK + ++++ + ++D Q A++ + H IK KQ EV
Sbjct: 183 ELGDDWERTEVLHKKFEEFQEELTARKGKVDRVNQYANECAQEKHPKLPEIKAKQDEVNA 242
Query: 208 RYSKLQEPLEKRKNKLNDAYKLHQFYRDADDEEDWIHEKEPIAGSTNVGRDLIGVQNLIK 387
+ +L KR+ L++A L +F RD ++ W+ EKEP S + G+DL+ + L
Sbjct: 243 AWDRLWSLALKRRESLSNAADLQRFKRDVNEAIQWMEEKEPQLTSEDYGKDLVSSEALFH 302
Query: 388 KHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANRDIEKKIDDMKNLWSDLKNKADKRRQ 567
H+ ++ + + ++ E+C + K++ + I++ D+ + W ++ A R
Sbjct: 303 NHKRLERNLAVMDDKVKELCAKADKLMISHSADALQIQQMKLDLVSNWERIRALATNRYA 362
Query: 568 LLDDSLEAQQYLADASEAESWMREKEPLVGSTEFGKDEDSTEALLKKHDALMADIEAYRS 747
L S ++L+D E WM+EK L+ + E D S EALL +H +I++Y
Sbjct: 363 KLKASYGYHRFLSDYDELSGWMKEKTALINADELPTDVASGEALLARHQQHKHEIDSYDD 422
Query: 748 TIDS 759
S
Sbjct: 423 RFQS 426
Score = 108 bits (270), Expect = 2e-23
Identities = 65/272 (23%), Positives = 133/272 (48%), Gaps = 5/272 (1%)
Frame = +1
Query: 31 CGKDLNSVTNLQKK---HNLLESDISSHQDRIDSFLQQADQFVHDNHFDADAIK-KKQIE 198
C + TN+Q+K H E++++ +++D + + + D D ++Q++
Sbjct: 1522 CDESYKDPTNIQRKYLKHQAFENEVNGRAEQVDGVINLGNSLIERRVCDGDEENMQEQLD 1581
Query: 199 VCNR-YSKLQEPLEKRKNKLNDAYKLHQFYRDADDEEDWIHEKEPIAGSTNVGRDLIGVQ 375
+ + L E + KLN+A + +F D E W+ E E + + RDL
Sbjct: 1582 MLKENWDYLLERTTDKGQKLNEASRQQRFNTSIRDFEFWLSEAEGLLAMKDQARDLTSAG 1641
Query: 376 NLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANRDIEKKIDDMKNLWSDLKNKAD 555
NL+KKHQ ++AE+ E + ++ + Q++I + IE+K++ + + ++++ A
Sbjct: 1642 NLLKKHQLLEAEMLAREDPLKDLNDLAQELISSGTFNIDQIEEKMNGVNERFENVQSLAA 1701
Query: 556 KRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFGKDEDSTEALLKKHDALMADIE 735
+ L ++ Q+ D + E+W+ EK V S ++G+D S + LLKKH L ++
Sbjct: 1702 AHHEKLKETYALFQFFQDLDDEEAWIEEKLLRVSSQDYGRDLQSVQNLLKKHKRLEGELV 1761
Query: 736 AYRSTIDSLRTQADACKMQEAPVSDSYGKETV 831
A+ + ++ A++ + + A GKE +
Sbjct: 1762 AHEPAVQNVLDTAESLRDKAA-----VGKEEI 1788
Score = 103 bits (257), Expect = 6e-22
Identities = 65/279 (23%), Positives = 130/279 (46%)
Frame = +1
Query: 1 EVESQLGSDDCGKDLNSVTNLQKKHNLLESDISSHQDRIDSFLQQADQFVHDNHFDADAI 180
E + + +D+ D+ S L +H + +I S+ DR S + + NH ++ I
Sbjct: 386 EKTALINADELPTDVASGEALLARHQQHKHEIDSYDDRFQSADATGQELLDGNHEASEEI 445
Query: 181 KKKQIEVCNRYSKLQEPLEKRKNKLNDAYKLHQFYRDADDEEDWIHEKEPIAGSTNVGRD 360
++K + N ++ L E +K +++ H FYRD++ + W+ +E + ++G
Sbjct: 446 REKMTILANDWAALLELWDKCQHQYRQCLDFHLFYRDSEQVDSWMSRQEAFLENEDLGNS 505
Query: 361 LIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANRDIEKKIDDMKNLWSDL 540
+ V+ L++KH + T E +I+ + K+ID +HY + +I D + L
Sbjct: 506 VGSVEALLQKHDDFEEAFTAQEEKIITLDETATKLIDNDHYDSENIAAIRDGLLARRDAL 565
Query: 541 KNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFGKDEDSTEALLKKHDAL 720
+ +A RR+LL DS QQ D+ + ++W+ +K+ L ++ KD + ++ ++K
Sbjct: 566 RERAATRRKLLVDSQLLQQLYQDSDDLKTWINKKKKLADDDDY-KDVQNLKSRVQKQQDF 624
Query: 721 MADIEAYRSTIDSLRTQADACKMQEAPVSDSYGKETVMA 837
++ +++L QE Y E V A
Sbjct: 625 EEELAVNEIMLNNLEKTG-----QEMIEDGHYASEAVAA 658
Score = 102 bits (255), Expect = 1e-21
Identities = 71/245 (28%), Positives = 121/245 (49%), Gaps = 4/245 (1%)
Frame = +1
Query: 55 TNLQKKHNLLESDISSHQ--DRIDSFLQQADQ--FVHDNHFDADAIKKKQIEVCNRYSKL 222
TN+Q K+ ES +S Q R+ L++ + F D HF +A K ++ + L
Sbjct: 83 TNIQGKYQKHESFVSEVQAKSRVLPELEEIREARFAED-HFAHEATKTHLKQLRLLWDLL 141
Query: 223 QEPLEKRKNKLNDAYKLHQFYRDADDEEDWIHEKEPIAGSTNVGRDLIGVQNLIKKHQAI 402
E +++ + L A K +Q+ ++ +D +W+ EKE I +G D + L KK +
Sbjct: 142 LELTQEKSDVLLRALKFYQYSQECEDILEWVKEKEAIVTLVELGDDWERTEVLHKKFEEF 201
Query: 403 QAEVTGHEPRILEVCNEGQKMIDGNHYANRDIEKKIDDMKNLWSDLKNKADKRRQLLDDS 582
Q E+T + ++ V + H +I+ K D++ W L + A KRR+ L ++
Sbjct: 202 QEELTARKGKVDRVNQYANECAQEKHPKLPEIKAKQDEVNAAWDRLWSLALKRRESLSNA 261
Query: 583 LEAQQYLADASEAESWMREKEPLVGSTEFGKDEDSTEALLKKHDALMADIEAYRSTIDSL 762
+ Q++ D +EA WM EKEP + S ++GKD S+EAL H L ++ + L
Sbjct: 262 ADLQRFKRDVNEAIQWMEEKEPQLTSEDYGKDLVSSEALFHNHKRLERNLAVMDDKVKEL 321
Query: 763 RTQAD 777
+AD
Sbjct: 322 CAKAD 326
Score = 102 bits (255), Expect = 1e-21
Identities = 56/247 (22%), Positives = 130/247 (52%)
Frame = +1
Query: 22 SDDCGKDLNSVTNLQKKHNLLESDISSHQDRIDSFLQQADQFVHDNHFDADAIKKKQIEV 201
+++ G +L+ V LQKK + + D+ S++ R+ + AD+ + + + +Q E+
Sbjct: 1101 TENTGVELDDVWELQKKFDEFQRDLKSNEPRLKDINKVADELLFEELLTPEGAHIRQ-EL 1159
Query: 202 CNRYSKLQEPLEKRKNKLNDAYKLHQFYRDADDEEDWIHEKEPIAGSTNVGRDLIGVQNL 381
R++ L+ +++ L+ A+ + F+R+ADD ++ I +K + + G DL+ VQ L
Sbjct: 1160 NTRWNSLKRLADEQYQLLSSAHAVEMFHREADDVKEQIDKKCRALNAADPGSDLLSVQAL 1219
Query: 382 IKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANRDIEKKIDDMKNLWSDLKNKADKR 561
++H+ + ++ ++ + +++ + + A D++K+ ++ W L+ R
Sbjct: 1220 QRQHECFERDIIPLGEKVNTLGETAERLCESHPDATEDLQKQRTELNEAWDTLQGLTSDR 1279
Query: 562 RQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFGKDEDSTEALLKKHDALMADIEAY 741
++ L+++ + +L+ AS+ E+W++ ++ S E +D TE LL++H DI+
Sbjct: 1280 KESLNEAHKFFLFLSKASDLENWIKTIGGVISSPELAEDLTGTEILLERHQEHHDDIKRE 1339
Query: 742 RSTIDSL 762
T +L
Sbjct: 1340 DPTFQAL 1346
Score = 99.4 bits (246), Expect = 1e-20
Identities = 56/211 (26%), Positives = 104/211 (49%)
Frame = +1
Query: 169 ADAIKKKQIEVCNRYSKLQEPLEKRKNKLNDAYKLHQFYRDADDEEDWIHEKEPIAGSTN 348
A+ I+ ++ EV N+Y + ++ + +R KL ++Y F RDADD E WI EK IA
Sbjct: 20 AEEIQHRRAEVLNQYQRFKDRVAERGQKLEESYHYQVFRRDADDLEKWIMEKLEIAKDKT 79
Query: 349 VGRDLIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANRDIEKKIDDMKNL 528
+ +Q +KH++ +EV + E+ + +H+A+ + + ++ L
Sbjct: 80 Y--EPTNIQGKYQKHESFVSEVQAKSRVLPELEEIREARFAEDHFAHEATKTHLKQLRLL 137
Query: 529 WSDLKNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFGKDEDSTEALLKK 708
W L ++ +L +L+ QY + + W++EKE +V E G D + TE L KK
Sbjct: 138 WDLLLELTQEKSDVLLRALKFYQYSQECEDILEWVKEKEAIVTLVELGDDWERTEVLHKK 197
Query: 709 HDALMADIEAYRSTIDSLRTQADACKMQEAP 801
+ ++ A + +D + A+ C ++ P
Sbjct: 198 FEEFQEELTARKGKVDRVNQYANECAQEKHP 228
Score = 64.3 bits (155), Expect = 4e-10
Identities = 48/207 (23%), Positives = 93/207 (44%), Gaps = 7/207 (3%)
Frame = +1
Query: 178 IKKKQIEVCNRYSKLQEPLEKRKNKLNDAYKLHQFYRDADDEEDWIHEKEPIAGSTNVGR 357
I + Q +V Y L + E+R+ +L Y +A D +WI EK+ + N G
Sbjct: 1051 IPQLQQQVETLYHSLLDRAEERRRRLLQRYNEFLLAYEAGDMLEWIQEKK----TENTGV 1106
Query: 358 DLIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMI-------DGNHYANRDIEKKIDD 516
+L V L KK Q ++ +EPR+ ++ +++ +G H +
Sbjct: 1107 ELDDVWELQKKFDEFQRDLKSNEPRLKDINKVADELLFEELLTPEGAHIRQ--------E 1158
Query: 517 MKNLWSDLKNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFGKDEDSTEA 696
+ W+ LK AD++ QLL + + + +A + + + +K + + + G D S +A
Sbjct: 1159 LNTRWNSLKRLADEQYQLLSSAHAVEMFHREADDVKEQIDKKCRALNAADPGSDLLSVQA 1218
Query: 697 LLKKHDALMADIEAYRSTIDSLRTQAD 777
L ++H+ DI +++L A+
Sbjct: 1219 LQRQHECFERDIIPLGEKVNTLGETAE 1245
>sp|P02549|SPTA1_HUMAN Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin)
Length = 2418
Score = 235 bits (600), Expect = 1e-61
Identities = 118/285 (41%), Positives = 178/285 (62%), Gaps = 1/285 (0%)
Frame = +1
Query: 1 EVESQLGSDDCGKDLNSVTNLQKKHNLLESDISSHQDRIDSFLQQADQFVHDNHFDADAI 180
+VE Q+ S+D GK L V N +KH LLES +++ QD++D A F H D+ I
Sbjct: 705 DVEWQVTSEDYGKGLAEVQNRLRKHGLLESAVAARQDQVDILTDLAAYFEEIGHPDSKDI 764
Query: 181 KKKQIEVCNRYSKLQEPLEKRKNKLNDAYKLHQFYRDADDEEDWIHEKEPIAGSTNVGRD 360
+ +Q + R+ L+EPL RK KL D L RD +DEE WI E EP A ST +G+D
Sbjct: 765 RARQESLVCRFEALKEPLATRKKKLLDLLHLQLICRDTEDEEAWIQETEPSATSTYLGKD 824
Query: 361 LIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANRDIEKKIDDMKNLWSDL 540
LI + L+ +H+ I + HEPRI E+ G KM++ H+A D+ ++ + L
Sbjct: 825 LIASKKLLNRHRVILENIASHEPRIQEITERGNKMVEEGHFAAEDVASRVKSLNQNMESL 884
Query: 541 KNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFGKDEDSTEALLKKHDAL 720
+ +A +R+ L+ +++ QQYLAD EAE+W+REKEP+V +T +G DE++ ALLKKH+A
Sbjct: 885 RARAARRQNDLEANVQFQQYLADLHEAETWIREKEPIVDNTNYGADEEAAGALLKKHEAF 944
Query: 721 MADIEAYRSTIDSLRTQADACKMQE-APVSDSYGKETVMALYDYQ 852
+ D+ ++ ++ +LR QA+AC+ Q+ APV G++ VMALYD+Q
Sbjct: 945 LLDLNSFGDSMKALRNQANACQQQQAAPVEGVAGEQRVMALYDFQ 989
Score = 167 bits (422), Expect = 4e-41
Identities = 91/259 (35%), Positives = 138/259 (53%)
Frame = +1
Query: 1 EVESQLGSDDCGKDLNSVTNLQKKHNLLESDISSHQDRIDSFLQQADQFVHDNHFDADAI 180
E E+ L D +DL S NL KKH LLE ++ + +D + A+ + F+ D I
Sbjct: 1624 EAETLLAMKDQARDLASAGNLLKKHQLLEREMLAREDALKDLNTLAEDLLSSGTFNVDQI 1683
Query: 181 KKKQIEVCNRYSKLQEPLEKRKNKLNDAYKLHQFYRDADDEEDWIHEKEPIAGSTNVGRD 360
KK+ V R+ +QE KL +AY L QF++D DDEE WI EK S + GRD
Sbjct: 1684 VKKKDNVNKRFLNVQELAAAHHEKLKEAYALFQFFQDLDDEESWIEEKLIRVSSQDYGRD 1743
Query: 361 LIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANRDIEKKIDDMKNLWSDL 540
L GVQNL+KKH+ ++ E+ HEP I V + +K+ D +I+ ++ W L
Sbjct: 1744 LQGVQNLLKKHKRLEGELVAHEPAIQNVLDMAEKLKDKAAVGQEEIQLRLAQFVEHWEKL 1803
Query: 541 KNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFGKDEDSTEALLKKHDAL 720
K A R L++SLE Q++ +A E E+W+ EK L + G +T++LL KH+AL
Sbjct: 1804 KELAKARGLKLEESLEYLQFMQNAEEEEAWINEKNALAVRGDCGDTLAATQSLLMKHEAL 1863
Query: 721 MADIEAYRSTIDSLRTQAD 777
D + + + ++ Q +
Sbjct: 1864 ENDFAVHETRVQNVCAQGE 1882
Score = 120 bits (301), Expect = 5e-27
Identities = 62/252 (24%), Positives = 138/252 (54%)
Frame = +1
Query: 7 ESQLGSDDCGKDLNSVTNLQKKHNLLESDISSHQDRIDSFLQQADQFVHDNHFDADAIKK 186
E+ L ++D G L S L +KH E ++ +++I + + A + + D+H+D++ IK
Sbjct: 496 EAFLENEDLGNSLGSAEALLQKHEDFEEAFTAQEEKIITVDKTATKLIGDDHYDSENIKA 555
Query: 187 KQIEVCNRYSKLQEPLEKRKNKLNDAYKLHQFYRDADDEEDWIHEKEPIAGSTNVGRDLI 366
+ + R L+E R+ L ++ L + Y D+DD ++WI++K+ +A + +D+
Sbjct: 556 IRDGLLARRDALREKAATRRRLLKESLLLQKLYEDSDDLKNWINKKKKLADDEDY-KDIQ 614
Query: 367 GVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANRDIEKKIDDMKNLWSDLKN 546
+++ ++K Q + E+ ++ ++ + GQ+MI+G HYA+ ++ ++ ++ +LW +L
Sbjct: 615 NLKSRVQKQQVFEKELAVNKTQLENIQKTGQEMIEGGHYASDNVTTRLSEVASLWEELLE 674
Query: 547 KADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFGKDEDSTEALLKKHDALMA 726
++ L ++ + Q+ +A + + W+ + E V S ++GK + L+KH L +
Sbjct: 675 ATKQKGTQLHEANQQLQFENNAEDLQRWLEDVEWQVTSEDYGKGLAEVQNRLRKHGLLES 734
Query: 727 DIEAYRSTIDSL 762
+ A + +D L
Sbjct: 735 AVAARQDQVDIL 746
Score = 120 bits (300), Expect = 6e-27
Identities = 81/273 (29%), Positives = 141/273 (51%), Gaps = 1/273 (0%)
Frame = +1
Query: 16 LGSDDCGKDLNSVTNLQKKHNLLESDISSHQDRIDSFLQQADQFVHDNHFDA-DAIKKKQ 192
L + D G DL SV LQ++H E D+ D++ + L + + + ++H DA + +++++
Sbjct: 1206 LSAADPGSDLFSVQALQRRHEGFERDLVPLGDKV-TILGETAERLSESHPDATEDLQRQK 1264
Query: 193 IEVCNRYSKLQEPLEKRKNKLNDAYKLHQFYRDADDEEDWIHEKEPIAGSTNVGRDLIGV 372
+E+ + LQ + RK LN+A K + F A D ++WI + S + DL G+
Sbjct: 1265 MELNEAWEDLQGRTKDRKESLNEAQKFYLFLSKARDLQNWISSIGGMVSSQELAEDLTGI 1324
Query: 373 QNLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANRDIEKKIDDMKNLWSDLKNKA 552
+ L+++HQ +A++ P + + ++ID H+A+ +IEKK+ +K DL+
Sbjct: 1325 EILLERHQEHRADMEAEAPTFQALEDFSAELIDSGHHASPEIEKKLQAVKLERDDLEKAW 1384
Query: 553 DKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFGKDEDSTEALLKKHDALMADI 732
+KR+++LD LE Q + + + ES M +E + S + DS EAL+KK D L I
Sbjct: 1385 EKRKKILDQCLELQMFQGNCDQVESRMVARENSLRSDD-KSSLDSLEALMKKRDDLDKAI 1443
Query: 733 EAYRSTIDSLRTQADACKMQEAPVSDSYGKETV 831
A I L A++ E Y KE +
Sbjct: 1444 TAQEGKITDLEHFAESLIADE-----HYAKEEI 1471
Score = 118 bits (296), Expect = 2e-26
Identities = 68/247 (27%), Positives = 125/247 (50%), Gaps = 3/247 (1%)
Frame = +1
Query: 13 QLGSDDCGKDLNSVTNLQKKHNLLESDISSHQDRIDSFLQQADQFVHDNHFDADAIKKKQ 192
++ S D G+DL V NL KKH LE ++ +H+ I + L A++ + I+ +
Sbjct: 1734 RVSSQDYGRDLQGVQNLLKKHKRLEGELVAHEPAIQNVLDMAEKLKDKAAVGQEEIQLRL 1793
Query: 193 IEVCNRYSKLQEPLEKRKNKLNDAYKLHQFYRDADDEEDWIHEKEPIAGSTNVGRDLIGV 372
+ + KL+E + R KL ++ + QF ++A++EE WI+EK +A + G L
Sbjct: 1794 AQFVEHWEKLKELAKARGLKLEESLEYLQFMQNAEEEEAWINEKNALAVRGDCGDTLAAT 1853
Query: 373 QNLIKKHQAIQAEVTGHEPRILEVCNEGQKMID---GNHYANRDIEKKIDDMKNLWSDLK 543
Q+L+ KH+A++ + HE R+ VC +G+ +++ N++I KI+ + L
Sbjct: 1854 QSLLMKHEALENDFAVHETRVQNVCAQGEDILNKVLHEESQNKEISSKIEALNEKTPSLA 1913
Query: 544 NKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFGKDEDSTEALLKKHDALM 723
+ L+D Q++ A E+W+ +KE + + G D LL K D L
Sbjct: 1914 KAIAAWKLQLEDDYAFQEFNWKADVVEAWIADKETSLKTNGNGADLGDFLTLLAKQDTLD 1973
Query: 724 ADIEAYR 744
A +++++
Sbjct: 1974 ASLQSFQ 1980
Score = 117 bits (294), Expect = 3e-26
Identities = 70/285 (24%), Positives = 133/285 (46%), Gaps = 3/285 (1%)
Frame = +1
Query: 1 EVESQLGSDDCGKDLNSVTNLQKKHNLLESDISSHQDRIDSFLQQADQFVHDNHFDADAI 180
E E L S+D GKDL + L H LE +++ D++ +A++ + DA I
Sbjct: 282 EKEPVLTSEDYGKDLVASEGLFHSHKGLERNLAVMSDKVKELCAKAEKLTLSHPSDAPQI 341
Query: 181 KKKQIEVCNRYSKLQEPLEKRKNKLNDAYKLHQFYRDADDEEDWIHEKEPIAGSTNVGRD 360
++ + ++ + + ++ R KL Y H+F D D+ W++EK + + D
Sbjct: 342 QEMKEDLVSSWEHIRALATSRYEKLQATYWYHRFSSDFDELSGWMNEKTAAINADELPTD 401
Query: 361 LIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANRDIEKKIDDMKNLWSDL 540
+ G + L+ +HQ + E+ ++ R GQ +++ NH A+ ++ +K++ + N W+ L
Sbjct: 402 VAGGEVLLDRHQQHKHEIDSYDDRFQSADETGQDLVNANHEASDEVREKMEILDNNWTAL 461
Query: 541 KNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFGKDEDSTEALLKKHDAL 720
D+R + + L+ + D+ + +SWM +E + + + G S EALL+KH+
Sbjct: 462 LELWDERHRQYEQCLDFHLFYRDSEQVDSWMSRQEAFLENEDLGNSLGSAEALLQKHEDF 521
Query: 721 MADIEAYRS---TIDSLRTQADACKMQEAPVSDSYGKETVMALYD 846
A T+D T+ D Y E + A+ D
Sbjct: 522 EEAFTAQEEKIITVDKTATKLIG--------DDHYDSENIKAIRD 558
Score = 113 bits (282), Expect = 8e-25
Identities = 74/261 (28%), Positives = 126/261 (48%), Gaps = 4/261 (1%)
Frame = +1
Query: 7 ESQLGSDDCGKDLNSVTNLQKKHNLLESDISSHQDRIDSFLQQADQFVHDNHFDADAIKK 186
E+ L SDD L+S+ L KK + L+ I++ + +I A+ + D H+ + I
Sbjct: 1415 ENSLRSDD-KSSLDSLEALMKKRDDLDKAITAQEGKITDLEHFAESLIADEHYAKEEIAT 1473
Query: 187 KQIEVCNRYSKLQEPLEKRKNKLNDAYKLHQFYRDADDEEDWIHEKEPIAGSTNVGRDLI 366
+ V +R+ L+ L + KL D L QFYRD ++ E+WI E P A + +D
Sbjct: 1474 RLQRVLDRWKALKAQLIDERTKLGDYANLKQFYRDLEELEEWISEMLPTACDESY-KDAT 1532
Query: 367 GVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMI----DGNHYANRDIEKKIDDMKNLWS 534
+Q KHQ EV G ++ V N G +I DGN A ++++++ +K W
Sbjct: 1533 NIQRKYLKHQTFAHEVDGRSEQVHGVINLGNSLIERSCDGNEEA---MKEQLEQLKEHWD 1589
Query: 535 DLKNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFGKDEDSTEALLKKHD 714
L + + + + L+++ Q++ + E W+ E E L+ + +D S LLKKH
Sbjct: 1590 HLLERTNDKGKKLNEASRQQRFNTSIRDFEFWLSEAETLLAMKDQARDLASAGNLLKKHQ 1649
Query: 715 ALMADIEAYRSTIDSLRTQAD 777
L ++ A + L T A+
Sbjct: 1650 LLEREMLAREDALKDLNTLAE 1670
Score = 107 bits (267), Expect = 4e-23
Identities = 61/246 (24%), Positives = 116/246 (47%)
Frame = +1
Query: 22 SDDCGKDLNSVTNLQKKHNLLESDISSHQDRIDSFLQQADQFVHDNHFDADAIKKKQIEV 201
S + G+D L KK + ++ + + R+ Q A++ +NH D I+ KQ EV
Sbjct: 183 SVELGEDWERTEVLHKKFEDFQVELVAKEGRVVEVNQYANECAEENHPDLPLIQSKQNEV 242
Query: 202 CNRYSKLQEPLEKRKNKLNDAYKLHQFYRDADDEEDWIHEKEPIAGSTNVGRDLIGVQNL 381
+ +L+ +R+ L++A L +F RD + WI EKEP+ S + G+DL+ + L
Sbjct: 243 NAAWERLRGLALQRQKALSNAANLQRFKRDVTEAIQWIKEKEPVLTSEDYGKDLVASEGL 302
Query: 382 IKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANRDIEKKIDDMKNLWSDLKNKADKR 561
H+ ++ + ++ E+C + +K+ + I++ +D+ + W ++ A R
Sbjct: 303 FHSHKGLERNLAVMSDKVKELCAKAEKLTLSHPSDAPQIQEMKEDLVSSWEHIRALATSR 362
Query: 562 RQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFGKDEDSTEALLKKHDALMADIEAY 741
+ L + ++ +D E WM EK + + E D E LL +H +I++Y
Sbjct: 363 YEKLQATYWYHRFSSDFDELSGWMNEKTAAINADELPTDVAGGEVLLDRHQQHKHEIDSY 422
Query: 742 RSTIDS 759
S
Sbjct: 423 DDRFQS 428
Score = 105 bits (263), Expect = 1e-22
Identities = 58/255 (22%), Positives = 127/255 (49%)
Frame = +1
Query: 1 EVESQLGSDDCGKDLNSVTNLQKKHNLLESDISSHQDRIDSFLQQADQFVHDNHFDADAI 180
E + + +D+ D+ L +H + +I S+ DR S + V+ NH +D +
Sbjct: 388 EKTAAINADELPTDVAGGEVLLDRHQQHKHEIDSYDDRFQSADETGQDLVNANHEASDEV 447
Query: 181 KKKQIEVCNRYSKLQEPLEKRKNKLNDAYKLHQFYRDADDEEDWIHEKEPIAGSTNVGRD 360
++K + N ++ L E ++R + H FYRD++ + W+ +E + ++G
Sbjct: 448 REKMEILDNNWTALLELWDERHRQYEQCLDFHLFYRDSEQVDSWMSRQEAFLENEDLGNS 507
Query: 361 LIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANRDIEKKIDDMKNLWSDL 540
L + L++KH+ + T E +I+ V K+I +HY + +I+ D + L
Sbjct: 508 LGSAEALLQKHEDFEEAFTAQEEKIITVDKTATKLIGDDHYDSENIKAIRDGLLARRDAL 567
Query: 541 KNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFGKDEDSTEALLKKHDAL 720
+ KA RR+LL +SL Q+ D+ + ++W+ +K+ L ++ KD + ++ ++K
Sbjct: 568 REKAATRRRLLKESLLLQKLYEDSDDLKNWINKKKKLADDEDY-KDIQNLKSRVQKQQVF 626
Query: 721 MADIEAYRSTIDSLR 765
++ ++ +++++
Sbjct: 627 EKELAVNKTQLENIQ 641
Score = 105 bits (263), Expect = 1e-22
Identities = 56/247 (22%), Positives = 130/247 (52%)
Frame = +1
Query: 22 SDDCGKDLNSVTNLQKKHNLLESDISSHQDRIDSFLQQADQFVHDNHFDADAIKKKQIEV 201
+++ G +L+ V LQKK + + D+++++ R+ + AD + + + + +Q E+
Sbjct: 1103 AENTGVELDDVWELQKKFDEFQKDLNTNEPRLRDINKVADDLLFEGLLTPEGAQIRQ-EL 1161
Query: 202 CNRYSKLQEPLEKRKNKLNDAYKLHQFYRDADDEEDWIHEKEPIAGSTNVGRDLIGVQNL 381
R+ LQ ++++ L A+ + F+R+ADD ++ I +K + + G DL VQ L
Sbjct: 1162 NARWGSLQRLADEQRQLLGSAHAVEVFHREADDTKEQIEKKCQALSAADPGSDLFSVQAL 1221
Query: 382 IKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANRDIEKKIDDMKNLWSDLKNKADKR 561
++H+ + ++ ++ + +++ + + A D++++ ++ W DL+ + R
Sbjct: 1222 QRRHEGFERDLVPLGDKVTILGETAERLSESHPDATEDLQRQKMELNEAWEDLQGRTKDR 1281
Query: 562 RQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFGKDEDSTEALLKKHDALMADIEAY 741
++ L+++ + +L+ A + ++W+ +V S E +D E LL++H AD+EA
Sbjct: 1282 KESLNEAQKFYLFLSKARDLQNWISSIGGMVSSQELAEDLTGIEILLERHQEHRADMEAE 1341
Query: 742 RSTIDSL 762
T +L
Sbjct: 1342 APTFQAL 1348
Score = 103 bits (257), Expect = 6e-22
Identities = 60/211 (28%), Positives = 107/211 (50%)
Frame = +1
Query: 169 ADAIKKKQIEVCNRYSKLQEPLEKRKNKLNDAYKLHQFYRDADDEEDWIHEKEPIAGSTN 348
A+ I++++ EV RY +E + +R KL D+Y L F RDADD WI EK I +
Sbjct: 21 AEEIQERRQEVLTRYQSFKERVAERGQKLEDSYHLQVFKRDADDLGKWIMEKVNILTDKS 80
Query: 349 VGRDLIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANRDIEKKIDDMKNL 528
D +Q +KHQ+++AEV + E+ ++ H A+ + + I+++++L
Sbjct: 81 Y-EDPTNIQGKYQKHQSLEAEVQTKSRLMSELEKTREERFTMGHSAHEETKAHIEELRHL 139
Query: 529 WSDLKNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFGKDEDSTEALLKK 708
W L ++ L +L+ QQY+ + ++ W+ +KE + S E G+D + TE L KK
Sbjct: 140 WDLLLELTLEKGDQLLRALKFQQYVQECADILEWIGDKEAIATSVELGEDWERTEVLHKK 199
Query: 709 HDALMADIEAYRSTIDSLRTQADACKMQEAP 801
+ ++ A + + A+ C + P
Sbjct: 200 FEDFQVELVAKEGRVVEVNQYANECAEENHP 230
Score = 101 bits (251), Expect = 3e-21
Identities = 60/260 (23%), Positives = 118/260 (45%), Gaps = 4/260 (1%)
Frame = +1
Query: 31 CGKDLNSVTNLQKK---HNLLESDISSHQDRIDSFLQQADQFVHDNHFDADAIKKKQIE- 198
C + TN+Q+K H ++ +++ + + + + + K+Q+E
Sbjct: 1524 CDESYKDATNIQRKYLKHQTFAHEVDGRSEQVHGVINLGNSLIERSCDGNEEAMKEQLEQ 1583
Query: 199 VCNRYSKLQEPLEKRKNKLNDAYKLHQFYRDADDEEDWIHEKEPIAGSTNVGRDLIGVQN 378
+ + L E + KLN+A + +F D E W+ E E + + RDL N
Sbjct: 1584 LKEHWDHLLERTNDKGKKLNEASRQQRFNTSIRDFEFWLSEAETLLAMKDQARDLASAGN 1643
Query: 379 LIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANRDIEKKIDDMKNLWSDLKNKADK 558
L+KKHQ ++ E+ E + ++ + ++ + I KK D++ + +++ A
Sbjct: 1644 LLKKHQLLEREMLAREDALKDLNTLAEDLLSSGTFNVDQIVKKKDNVNKRFLNVQELAAA 1703
Query: 559 RRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFGKDEDSTEALLKKHDALMADIEA 738
+ L ++ Q+ D + ESW+ EK V S ++G+D + LLKKH L ++ A
Sbjct: 1704 HHEKLKEAYALFQFFQDLDDEESWIEEKLIRVSSQDYGRDLQGVQNLLKKHKRLEGELVA 1763
Query: 739 YRSTIDSLRTQADACKMQEA 798
+ I ++ A+ K + A
Sbjct: 1764 HEPAIQNVLDMAEKLKDKAA 1783
Score = 100 bits (250), Expect = 4e-21
Identities = 64/250 (25%), Positives = 121/250 (48%), Gaps = 3/250 (1%)
Frame = +1
Query: 37 KDLNSVTNLQ---KKHNLLESDISSHQDRIDSFLQQADQFVHDNHFDADAIKKKQIEVCN 207
K TN+Q +KH LE+++ + + + ++ H + K E+ +
Sbjct: 79 KSYEDPTNIQGKYQKHQSLEAEVQTKSRLMSELEKTREERFTMGHSAHEETKAHIEELRH 138
Query: 208 RYSKLQEPLEKRKNKLNDAYKLHQFYRDADDEEDWIHEKEPIAGSTNVGRDLIGVQNLIK 387
+ L E ++ ++L A K Q+ ++ D +WI +KE IA S +G D + L K
Sbjct: 139 LWDLLLELTLEKGDQLLRALKFQQYVQECADILEWIGDKEAIATSVELGEDWERTEVLHK 198
Query: 388 KHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANRDIEKKIDDMKNLWSDLKNKADKRRQ 567
K + Q E+ E R++EV + + NH I+ K +++ W L+ A +R++
Sbjct: 199 KFEDFQVELVAKEGRVVEVNQYANECAEENHPDLPLIQSKQNEVNAAWERLRGLALQRQK 258
Query: 568 LLDDSLEAQQYLADASEAESWMREKEPLVGSTEFGKDEDSTEALLKKHDALMADIEAYRS 747
L ++ Q++ D +EA W++EKEP++ S ++GKD ++E L H L ++
Sbjct: 259 ALSNAANLQRFKRDVTEAIQWIKEKEPVLTSEDYGKDLVASEGLFHSHKGLERNLAVMSD 318
Query: 748 TIDSLRTQAD 777
+ L +A+
Sbjct: 319 KVKELCAKAE 328
Score = 67.0 bits (162), Expect = 6e-11
Identities = 43/185 (23%), Positives = 88/185 (47%)
Frame = +1
Query: 178 IKKKQIEVCNRYSKLQEPLEKRKNKLNDAYKLHQFYRDADDEEDWIHEKEPIAGSTNVGR 357
I ++Q ++ N+Y L + E+R+ +L Y +A D +WI EK+ + N G
Sbjct: 1053 ITQRQEQIENQYRSLLDRAEERRRRLLQRYNEFLLAYEAGDMLEWIQEKK----AENTGV 1108
Query: 358 DLIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANRDIEKKIDDMKNLWSD 537
+L V L KK Q ++ +EPR+ ++ ++ + + ++ W
Sbjct: 1109 ELDDVWELQKKFDEFQKDLNTNEPRLRDINKVADDLLFEGLLTPEGAQIR-QELNARWGS 1167
Query: 538 LKNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFGKDEDSTEALLKKHDA 717
L+ AD++RQLL + + + +A + + + +K + + + G D S +AL ++H+
Sbjct: 1168 LQRLADEQRQLLGSAHAVEVFHREADDTKEQIEKKCQALSAADPGSDLFSVQALQRRHEG 1227
Query: 718 LMADI 732
D+
Sbjct: 1228 FERDL 1232
>sp|P16546|SPTA2_MOUSE Spectrin alpha chain, brain (Spectrin, non-erythroid alpha chain)
(Alpha-II spectrin) (Fodrin alpha chain)
Length = 1458
Score = 220 bits (560), Expect = 4e-57
Identities = 107/256 (41%), Positives = 162/256 (63%)
Frame = +1
Query: 1 EVESQLGSDDCGKDLNSVTNLQKKHNLLESDISSHQDRIDSFLQQADQFVHDNHFDADAI 180
EVE+ L S+D GKDL SV NL KKH LLE+DIS+H+DR+ QAD + + FD +
Sbjct: 662 EVEALLASEDYGKDLASVNNLLKKHQLLEADISAHEDRLKDLNSQADSLMTSSAFDTSQV 721
Query: 181 KKKQIEVCNRYSKLQEPLEKRKNKLNDAYKLHQFYRDADDEEDWIHEKEPIAGSTNVGRD 360
K+K+ + R+ K++ R+ KL+++++LHQF+RD DDEE WI EK+ + S + GRD
Sbjct: 722 KEKRDTINGRFQKIKSMATSRRAKLSESHRLHQFFRDMDDEESWIKEKKLLVSSEDYGRD 781
Query: 361 LIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANRDIEKKIDDMKNLWSDL 540
L GVQNL KKH+ ++AE+ HEP I V + G+K+ D N +I++++ W +L
Sbjct: 782 LTGVQNLRKKHKRLEAELAAHEPAIQGVLDTGKKLSDDNTIGQEEIQQRLAQFVEHWKEL 841
Query: 541 KNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFGKDEDSTEALLKKHDAL 720
K A R Q L++SLE QQ++A+ E E+W+ EK LV S ++G + + LLKKH+A
Sbjct: 842 KQLAAARGQRLEESLEYQQFVANVEEEEAWINEKMTLVASEDYGDTLAAIQGLLKKHEAF 901
Query: 721 MADIEAYRSTIDSLRT 768
D ++ ++ + T
Sbjct: 902 ETDFTVHKDRVNDVCT 917
Score = 150 bits (379), Expect = 4e-36
Identities = 78/261 (29%), Positives = 143/261 (54%), Gaps = 4/261 (1%)
Frame = +1
Query: 16 LGSDDCGKDLNSVTNLQKKHNLLESDISSHQDRIDSFLQQADQFVHDNHFDADAIKKKQI 195
+ S+D G+DL V NL+KKH LE+++++H+ I L + DN + I+++
Sbjct: 773 VSSEDYGRDLTGVQNLRKKHKRLEAELAAHEPAIQGVLDTGKKLSDDNTIGQEEIQQRLA 832
Query: 196 EVCNRYSKLQEPLEKRKNKLNDAYKLHQFYRDADDEEDWIHEKEPIAGSTNVGRDLIGVQ 375
+ + +L++ R +L ++ + QF + ++EE WI+EK + S + G L +Q
Sbjct: 833 QFVEHWKELKQLAAARGQRLEESLEYQQFVANVEEEEAWINEKMTLVASEDYGDTLAAIQ 892
Query: 376 NLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANRDIEKKIDDMKNLWSDLKNKAD 555
L+KKH+A + + T H+ R+ +VC GQ +I N++ +I K+ + SDL+ A
Sbjct: 893 GLLKKHEAFETDFTVHKDRVNDVCTNGQDLIKKNNHHEENISSKMKGLNGKVSDLEKAAA 952
Query: 556 KRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFGKDEDSTEALLKKHDALMADIE 735
+R+ LD++ Q+ A ESW+ EKE + + ++G+D S + LL K + A ++
Sbjct: 953 QRKAKLDENSAFLQFNWKADVVESWIGEKENSLKTDDYGRDLSSVQTLLTKQETFDAGLQ 1012
Query: 736 AYR----STIDSLRTQADACK 786
A++ + I +L+ Q A K
Sbjct: 1013 AFQQEGIANITALKDQLLAAK 1033
Score = 138 bits (347), Expect = 2e-32
Identities = 77/259 (29%), Positives = 137/259 (52%)
Frame = +1
Query: 1 EVESQLGSDDCGKDLNSVTNLQKKHNLLESDISSHQDRIDSFLQQADQFVHDNHFDADAI 180
E L +D+ G DL SV LQ+KH E D+++ D+++S + A + + + A+ +
Sbjct: 237 EKNQALNTDNYGHDLASVQALQRKHEGFERDLAALGDKVNSLGETAQRLIQSHPESAEDL 296
Query: 181 KKKQIEVCNRYSKLQEPLEKRKNKLNDAYKLHQFYRDADDEEDWIHEKEPIAGSTNVGRD 360
K+K E+ ++ L + ++RK KL D++ L +F D D WI+ + S + +D
Sbjct: 297 KEKCTELNQAWTSLGKRADQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGLVSSDELAKD 356
Query: 361 LIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANRDIEKKIDDMKNLWSDL 540
+ G + L+++HQ + E+ GQ+++ HYA+ +I++K+D + +DL
Sbjct: 357 VTGAEALLERHQEHRTEIDARAGTFQAFEQFGQQLLAHGHYASPEIKEKLDILDQERTDL 416
Query: 541 KNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFGKDEDSTEALLKKHDAL 720
+ +RR +LD LE Q + D +AE+WM +E + + + G DS EAL+KKH+
Sbjct: 417 EKAWVQRRMMLDHCLELQLFHRDCEQAENWMAAREAFLNTEDKGDSLDSVEALIKKHEDF 476
Query: 721 MADIEAYRSTIDSLRTQAD 777
I I +L+ AD
Sbjct: 477 DKAINVQEEKIAALQAFAD 495
Score = 134 bits (338), Expect = 2e-31
Identities = 80/266 (30%), Positives = 142/266 (53%), Gaps = 2/266 (0%)
Frame = +1
Query: 7 ESQLGSDDCGKDLNSVTNLQKKHNLLESDISSHQDRIDSFLQQADQFVHDNHFDADAIKK 186
E+ L ++D G L+SV L KKH + I+ +++I + ADQ + +H+ I
Sbjct: 451 EAFLNTEDKGDSLDSVEALIKKHEDFDKAINVQEEKIAALQAFADQLIAVDHYAKGDIAN 510
Query: 187 KQIEVCNRYSKLQEPLEKRKNKLNDAYKLHQFYRDADDEEDWIHEKEPIAGSTNVGRDLI 366
++ EV +R+ +L+ + ++++KL ++ L QF RD D+ E WI EK A + +D
Sbjct: 511 RRNEVLDRWRRLKAQMIEKRSKLGESQTLQQFSRDVDEIEAWISEKLQTASDESY-KDPT 569
Query: 367 GVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANRD--IEKKIDDMKNLWSDL 540
+Q+ +KHQA +AE+ + RI V + G +I+ A + ++ ++ + + W L
Sbjct: 570 NIQSKHQKHQAFEAELHANADRIRGVIDMGNSLIERGACAGSEDAVKARLAALADQWQFL 629
Query: 541 KNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFGKDEDSTEALLKKHDAL 720
K+ ++ Q L ++ + Q + + + W+ E E L+ S ++GKD S LLKKH L
Sbjct: 630 VQKSAEKSQKLKEANKQQNFNTGIKDFDFWLSEVEALLASEDYGKDLASVNNLLKKHQLL 689
Query: 721 MADIEAYRSTIDSLRTQADACKMQEA 798
ADI A+ + L +QAD+ A
Sbjct: 690 EADISAHEDRLKDLNSQADSLMTSSA 715
Score = 133 bits (335), Expect = 5e-31
Identities = 67/252 (26%), Positives = 131/252 (51%), Gaps = 2/252 (0%)
Frame = +1
Query: 13 QLGSDDCGKDLNSVTNLQKKHNLLESDISSHQDRIDSFLQQADQFVHDNHF--DADAIKK 186
Q SD+ KD ++ + +KH E+++ ++ DRI + + + DA+K
Sbjct: 558 QTASDESYKDPTNIQSKHQKHQAFEAELHANADRIRGVIDMGNSLIERGACAGSEDAVKA 617
Query: 187 KQIEVCNRYSKLQEPLEKRKNKLNDAYKLHQFYRDADDEEDWIHEKEPIAGSTNVGRDLI 366
+ + +++ L + ++ KL +A K F D + W+ E E + S + G+DL
Sbjct: 618 RLAALADQWQFLVQKSAEKSQKLKEANKQQNFNTGIKDFDFWLSEVEALLASEDYGKDLA 677
Query: 367 GVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANRDIEKKIDDMKNLWSDLKN 546
V NL+KKHQ ++A+++ HE R+ ++ ++ ++ + + +++K D + + +K+
Sbjct: 678 SVNNLLKKHQLLEADISAHEDRLKDLNSQADSLMTSSAFDTSQVKEKRDTINGRFQKIKS 737
Query: 547 KADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFGKDEDSTEALLKKHDALMA 726
A RR L +S Q+ D + ESW++EK+ LV S ++G+D + L KKH L A
Sbjct: 738 MATSRRAKLSESHRLHQFFRDMDDEESWIKEKKLLVSSEDYGRDLTGVQNLRKKHKRLEA 797
Query: 727 DIEAYRSTIDSL 762
++ A+ I +
Sbjct: 798 ELAAHEPAIQGV 809
Score = 124 bits (310), Expect = 4e-28
Identities = 72/289 (24%), Positives = 138/289 (47%), Gaps = 36/289 (12%)
Frame = +1
Query: 1 EVESQLGSDDCGKDLNSVTNLQKKHNLLESDISSHQDRIDSFLQQADQFVHDNHF--DAD 174
E E+ L +++ G DL V LQKK + + D+ +++ R+ + A+ + +
Sbjct: 95 EKEAALTNEEVGADLEQVEVLQKKFDDFQKDLKANESRLKDINKVAEDLESEGLMAEEVQ 154
Query: 175 AIKKKQI----------------------------------EVCNRYSKLQEPLEKRKNK 252
A++++++ E+ R+ LQ+ E+R
Sbjct: 155 AVQQQEVYGAMPRDEADSKTASPWKSARLMVHTVATFNSIKELNERWRSLQQLAEERSQL 214
Query: 253 LNDAYKLHQFYRDADDEEDWIHEKEPIAGSTNVGRDLIGVQNLIKKHQAIQAEVTGHEPR 432
L A+++ +F+RDAD+ ++WI EK + N G DL VQ L +KH+ + ++ +
Sbjct: 215 LGSAHEVQRFHRDADETKEWIEEKNQALNTDNYGHDLASVQALQRKHEGFERDLAALGDK 274
Query: 433 ILEVCNEGQKMIDGNHYANRDIEKKIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYLADA 612
+ + Q++I + + D+++K ++ W+ L +AD+R+ L DS + Q++L+D
Sbjct: 275 VNSLGETAQRLIQSHPESAEDLKEKCTELNQAWTSLGKRADQRKAKLGDSHDLQRFLSDF 334
Query: 613 SEAESWMREKEPLVGSTEFGKDEDSTEALLKKHDALMADIEAYRSTIDS 759
+ SW+ LV S E KD EALL++H +I+A T +
Sbjct: 335 RDLMSWINGIRGLVSSDELAKDVTGAEALLERHQEHRTEIDARAGTFQA 383
Score = 105 bits (261), Expect = 2e-22
Identities = 63/245 (25%), Positives = 118/245 (48%)
Frame = +1
Query: 4 VESQLGSDDCGKDLNSVTNLQKKHNLLESDISSHQDRIDSFLQQADQFVHDNHFDADAIK 183
+ + SD+ KD+ L ++H ++I + +F Q Q + H+ + IK
Sbjct: 344 IRGLVSSDELAKDVTGAEALLERHQEHRTEIDARAGTFQAFEQFGQQLLAHGHYASPEIK 403
Query: 184 KKQIEVCNRYSKLQEPLEKRKNKLNDAYKLHQFYRDADDEEDWIHEKEPIAGSTNVGRDL 363
+K + + L++ +R+ L+ +L F+RD + E+W+ +E + + G L
Sbjct: 404 EKLDILDQERTDLEKAWVQRRMMLDHCLELQLFHRDCEQAENWMAAREAFLNTEDKGDSL 463
Query: 364 IGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANRDIEKKIDDMKNLWSDLK 543
V+ LIKKH+ + E +I + ++I +HYA DI + +++ + W LK
Sbjct: 464 DSVEALIKKHEDFDKAINVQEEKIAALQAFADQLIAVDHYAKGDIANRRNEVLDRWRRLK 523
Query: 544 NKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFGKDEDSTEALLKKHDALM 723
+ ++R L +S QQ+ D E E+W+ EK S E KD + ++ +KH A
Sbjct: 524 AQMIEKRSKLGESQTLQQFSRDVDEIEAWISEKLQ-TASDESYKDPTNIQSKHQKHQAFE 582
Query: 724 ADIEA 738
A++ A
Sbjct: 583 AELHA 587
Score = 87.4 bits (215), Expect = 4e-17
Identities = 58/233 (24%), Positives = 103/233 (44%), Gaps = 37/233 (15%)
Frame = +1
Query: 175 AIKKKQIEVCNRYSKLQEPLEKRKNKLNDAYKLHQFYRDADDEEDWIHEKEPIAGSTNVG 354
+I +Q ++ N+Y L E EKRK L + K +R+A++ + WI EKE + VG
Sbjct: 47 SIALRQGQIDNQYQSLLELGEKRKGMLEKSCKKFMLFREANELQQWITEKEAALTNEEVG 106
Query: 355 RDLIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANRDIE----------- 501
DL V+ L KK Q ++ +E R+ ++ N+ + ++ +++
Sbjct: 107 ADLEQVEVLQKKFDDFQKDLKANESRLKDI-NKVAEDLESEGLMAEEVQAVQQQEVYGAM 165
Query: 502 --------------------------KKIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYL 603
I ++ W L+ A++R QLL + E Q++
Sbjct: 166 PRDEADSKTASPWKSARLMVHTVATFNSIKELNERWRSLQQLAEERSQLLGSAHEVQRFH 225
Query: 604 ADASEAESWMREKEPLVGSTEFGKDEDSTEALLKKHDALMADIEAYRSTIDSL 762
DA E + W+ EK + + +G D S +AL +KH+ D+ A ++SL
Sbjct: 226 RDADETKEWIEEKNQALNTDNYGHDLASVQALQRKHEGFERDLAALGDKVNSL 278
Score = 58.9 bits (141), Expect = 2e-08
Identities = 68/294 (23%), Positives = 123/294 (41%), Gaps = 23/294 (7%)
Frame = +1
Query: 1 EVESQLGSDDCGKDLNSVTNLQKKHNLLESDISS-HQDRIDSFLQQADQFVHDNHFDADA 177
E E+ L +DD G+DL+SV L K ++ + + Q+ I + DQ + H + A
Sbjct: 980 EKENSLKTDDYGRDLSSVQTLLTKQETFDAGLQAFQQEGIANITALKDQLLAAKHIQSKA 1039
Query: 178 IKKKQIEVCNRYSKLQEPLEKRKNKLNDAYKLHQ--------FYRDADDEEDWIHEKEPI 333
I+ + + R+++L RK KL +A + F + A W E
Sbjct: 1040 IEARHASLMKRWTQLLANSATRKKKLLEAQSHFRKVEDLFLTFAKKASAFNSWFENAEED 1099
Query: 334 AGSTNVGRDLIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKM----IDGNHYANRDIE 501
L ++ L + H A ++ ++ + ++ +++ + N Y +E
Sbjct: 1100 LTDPVRCNSLEEIKALREAHDAFRSSLSSAQADFNQLAELDRQIKSFRVASNPYTWFTME 1159
Query: 502 KKIDDMKNLWSDLKNK-----ADKRRQLLDDSLEAQQYLADASEAESWMREKEP--LVGS 660
+ +NL +K + ++RRQ +D L Q++ A+ W++E L GS
Sbjct: 1160 ALEETWRNLQKIIKERELELQKEQRRQEENDKLR-QEFAQHANAFHQWIQETRTYLLDGS 1218
Query: 661 ---TEFGKDEDSTEALLKKHDALMADIEAYRSTIDSLRTQADACKMQEAPVSDS 813
E G E EA +KH +I A RS + + A M+EA + D+
Sbjct: 1219 CMVEESGTLESQLEATKRKHQ----EIRAMRSQLKKIEDLGAA--MEEALILDN 1266
Score = 47.8 bits (112), Expect = 4e-05
Identities = 24/85 (28%), Positives = 42/85 (49%)
Frame = +1
Query: 523 NLWSDLKNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFGKDEDSTEALL 702
N + L +KR+ +L+ S + +A+E + W+ EKE + + E G D + E L
Sbjct: 57 NQYQSLLELGEKRKGMLEKSCKKFMLFREANELQQWITEKEAALTNEEVGADLEQVEVLQ 116
Query: 703 KKHDALMADIEAYRSTIDSLRTQAD 777
KK D D++A S + + A+
Sbjct: 117 KKFDDFQKDLKANESRLKDINKVAE 141
>sp|Q01082|SPTB2_HUMAN Spectrin beta chain, brain 1 (Spectrin, non-erythroid beta chain 1)
(Beta-II spectrin) (Fodrin beta chain)
Length = 2364
Score = 180 bits (457), Expect = 4e-45
Identities = 100/270 (37%), Positives = 155/270 (57%), Gaps = 1/270 (0%)
Frame = +1
Query: 4 VESQLGSDDCGKDLNSVTNLQKKHNLLESDISSHQDRIDSFLQQADQFVHDNHFDADAIK 183
+ESQ+ SDD GK L SV L KK +LE+ + + I+ QA + D +
Sbjct: 1399 LESQIQSDDYGKHLTSVNILLKKQQMLENQMEVRKKEIEELQSQAQALSQEGK-STDEVD 1457
Query: 184 KKQIEVCNRYSKLQEPLEKRKNKLNDAYKLHQFYRDADDEEDWIHEKEPIAGSTNVGRDL 363
K++ V ++ +L EPL +RK+ L + ++HQF RD +DE W+ E+ P+A ST+ G +L
Sbjct: 1458 SKRLTVQTKFMELLEPLNERKHNLLASKEIHQFNRDVEDEILWVGERMPLATSTDHGHNL 1517
Query: 364 IGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMI-DGNHYANRDIEKKIDDMKNLWSDL 540
VQ LIKK+Q +Q E+ GH+PRI ++ Q ++ D + + I +++ D+K LW L
Sbjct: 1518 QTVQLLIKKNQTLQKEIQGHQPRIDDIFERSQNIVTDSSSLSAEAIRQRLADLKQLWGLL 1577
Query: 541 KNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFGKDEDSTEALLKKHDAL 720
+ +KR + L+++ AQQY DA+EAE+WM E+E + S E KDE S ++LKKH L
Sbjct: 1578 IEETEKRHRRLEEAHRAQQYYFDAAEAEAWMSEQELYMMSEEKAKDEQSAVSMLKKHQIL 1637
Query: 721 MADIEAYRSTIDSLRTQADACKMQEAPVSD 810
+E Y T+ L + A P S+
Sbjct: 1638 EQAVEDYAETVHQLSKTSRALVADSHPESE 1667
Score = 152 bits (385), Expect = 9e-37
Identities = 84/271 (30%), Positives = 147/271 (54%), Gaps = 4/271 (1%)
Frame = +1
Query: 22 SDDCGKDLNSVTNLQKKHNLLESDISSHQDRIDSFLQQADQFVHDNH----FDADAIKKK 189
S D GK L V +L +KH L+E+DI +R+ A +F D D I+ +
Sbjct: 553 SQDYGKHLLGVEDLLQKHTLVEADIGIQAERVRGVNASAQKFATDGEGYKPCDPQVIRDR 612
Query: 190 QIEVCNRYSKLQEPLEKRKNKLNDAYKLHQFYRDADDEEDWIHEKEPIAGSTNVGRDLIG 369
+ Y +L + +R+ +L ++ +L +F+ + +EE WI EKE I S + G+DL
Sbjct: 613 VAHMEFCYQELCQLAAERRARLEESRRLWKFFWEMAEEEGWIREKEKILSSDDYGKDLTS 672
Query: 370 VQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANRDIEKKIDDMKNLWSDLKNK 549
V L+ KH+A + E++G + EG+ MI H+ + I ++I ++ W++L+
Sbjct: 673 VMRLLSKHRAFEDEMSGRSGHFEQAIKEGEDMIAEEHFGSEKIRERIIYIREQWANLEQL 732
Query: 550 ADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFGKDEDSTEALLKKHDALMAD 729
+ R++ L+++ Q+ ADA + ++WM + +V S++ G DE ST++L+KKH + +
Sbjct: 733 SAIRKKRLEEASLLHQFQADADDIDAWMLDILKIVSSSDVGHDEYSTQSLVKKHKDVAEE 792
Query: 730 IEAYRSTIDSLRTQADACKMQEAPVSDSYGK 822
I YR T+D+L QA A + A D G+
Sbjct: 793 IANYRPTLDTLHEQASALPQEHAESPDVRGR 823
Score = 126 bits (316), Expect = 9e-29
Identities = 65/251 (25%), Positives = 128/251 (50%)
Frame = +1
Query: 1 EVESQLGSDDCGKDLNSVTNLQKKHNLLESDISSHQDRIDSFLQQADQFVHDNHFDADAI 180
E E L SDD GKDL SV L KH E ++S + +++ + + + HF ++ I
Sbjct: 656 EKEKILSSDDYGKDLTSVMRLLSKHRAFEDEMSGRSGHFEQAIKEGEDMIAEEHFGSEKI 715
Query: 181 KKKQIEVCNRYSKLQEPLEKRKNKLNDAYKLHQFYRDADDEEDWIHEKEPIAGSTNVGRD 360
+++ I + +++ L++ RK +L +A LHQF DADD + W+ + I S++VG D
Sbjct: 716 RERIIYIREQWANLEQLSAIRKKRLEEASLLHQFQADADDIDAWMLDILKIVSSSDVGHD 775
Query: 361 LIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANRDIEKKIDDMKNLWSDL 540
Q+L+KKH+ + E+ + P L+ +E + H + D+ ++ ++ + ++
Sbjct: 776 EYSTQSLVKKHKDVAEEIANYRP-TLDTLHEQASALPQEHAESPDVRGRLSGIEERYKEV 834
Query: 541 KNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFGKDEDSTEALLKKHDAL 720
R+Q L D+L + ++A E W+ EKE + + + + + E + + ++L
Sbjct: 835 AELTRLRKQALQDTLALYKMFSEADACELWIDEKEQWLNNMQIPEKLEDLEVIQHRFESL 894
Query: 721 MADIEAYRSTI 753
++ S +
Sbjct: 895 EPEMNNQASRV 905
Score = 121 bits (304), Expect = 2e-27
Identities = 78/272 (28%), Positives = 140/272 (51%), Gaps = 2/272 (0%)
Frame = +1
Query: 1 EVESQLGSDDCGKDLNSVTNLQKKHNLLESDISSHQDRIDSFLQQADQFVHDNHFDADAI 180
E E + S++ KD S ++ KKH +LE + + + + + + V D+H +++ I
Sbjct: 1610 EQELYMMSEEKAKDEQSAVSMLKKHQILEQAVEDYAETVHQLSKTSRALVADSHPESERI 1669
Query: 181 KKKQIEVCNRYSKLQEPLEKRKNKLNDAYKLHQFYRDADDEEDWIHEKEPIAGSTNVGRD 360
+Q +V Y+ L++ E+R+ KL++ ++L Q R+ DD E WI E+E +AGS +G+D
Sbjct: 1670 SMRQSKVDKLYAGLKDLAEERRGKLDERHRLFQLNREVDDLEQWIAEREVVAGSHELGQD 1729
Query: 361 LIGVQNLIKKHQAIQAEVTGH--EPRILEVCNEGQKMIDGNHYANRDIEKKIDDMKNLWS 534
V L ++ + A TG+ + R+ V + ++I+ H I + D + W+
Sbjct: 1730 YEHVTMLQERFREF-ARDTGNIGQERVDTVNHLADELINSGHSDAATIAEWKDGLNEAWA 1788
Query: 535 DLKNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFGKDEDSTEALLKKHD 714
DL D R Q+L S E ++ DA E +++K + E G+D+++ E L + H
Sbjct: 1789 DLLELIDTRTQILAASYELHKFYHDAKEIFGRIQDKHKKL-PEELGRDQNTVETLQRMHT 1847
Query: 715 ALMADIEAYRSTIDSLRTQADACKMQEAPVSD 810
DI+A + + L Q DA ++Q A D
Sbjct: 1848 TFEHDIQALGTQVRQL--QEDAARLQAAYAGD 1877
Score = 114 bits (284), Expect = 4e-25
Identities = 69/243 (28%), Positives = 127/243 (52%), Gaps = 4/243 (1%)
Frame = +1
Query: 1 EVESQLGSDDCGKDLNSVTNLQKKHNLLESDISSHQDRIDSFLQQADQFVHDNHFDADAI 180
E + + D+ G DL +V KKH +E+DI+++++R+ + + A + +N+ D I
Sbjct: 440 ENQRLVSQDNFGFDLPAVEAATKKHEAIETDIAAYEERVQAVVAVARELEAENYHDIKRI 499
Query: 181 KKKQIEVCNRYSKLQEPLEKRKNKLNDAYKLHQFYRDADDEEDWIHEKEPIAGSTNVGRD 360
++ V + L E L R+ +L L + +++ DW+ E + + S + G+
Sbjct: 500 TARKDNVIRLWEYLLELLRARRQRLEMNLGLQKIFQEMLYIMDWMDEMKVLVLSQDYGKH 559
Query: 361 LIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKM-IDGNHYANRD---IEKKIDDMKNL 528
L+GV++L++KH ++A++ R+ V QK DG Y D I ++ M+
Sbjct: 560 LLGVEDLLQKHTLVEADIGIQAERVRGVNASAQKFATDGEGYKPCDPQVIRDRVAHMEFC 619
Query: 529 WSDLKNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFGKDEDSTEALLKK 708
+ +L A +RR L++S ++ + +E E W+REKE ++ S ++GKD S LL K
Sbjct: 620 YQELCQLAAERRARLEESRRLWKFFWEMAEEEGWIREKEKILSSDDYGKDLTSVMRLLSK 679
Query: 709 HDA 717
H A
Sbjct: 680 HRA 682
Score = 112 bits (280), Expect = 1e-24
Identities = 63/230 (27%), Positives = 119/230 (51%), Gaps = 1/230 (0%)
Frame = +1
Query: 22 SDDCGKDLNSVTNLQKKHNLLESDISSHQDRIDSFLQQADQFVHDNH-FDADAIKKKQIE 198
S D G +L +V L KK+ L+ +I HQ RID +++ V D+ A+AI+++ +
Sbjct: 1510 STDHGHNLQTVQLLIKKNQTLQKEIQGHQPRIDDIFERSQNIVTDSSSLSAEAIRQRLAD 1569
Query: 199 VCNRYSKLQEPLEKRKNKLNDAYKLHQFYRDADDEEDWIHEKEPIAGSTNVGRDLIGVQN 378
+ + L E EKR +L +A++ Q+Y DA + E W+ E+E S +D +
Sbjct: 1570 LKQLWGLLIEETEKRHRRLEEAHRAQQYYFDAAEAEAWMSEQELYMMSEEKAKDEQSAVS 1629
Query: 379 LIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANRDIEKKIDDMKNLWSDLKNKADK 558
++KKHQ ++ V + + ++ + ++ +H + I + + L++ LK+ A++
Sbjct: 1630 MLKKHQILEQAVEDYAETVHQLSKTSRALVADSHPESERISMRQSKVDKLYAGLKDLAEE 1689
Query: 559 RRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFGKDEDSTEALLKK 708
RR LD+ Q + + E W+ E+E + GS E G+D + L ++
Sbjct: 1690 RRGKLDERHRLFQLNREVDDLEQWIAEREVVAGSHELGQDYEHVTMLQER 1739
Score = 107 bits (268), Expect = 3e-23
Identities = 61/255 (23%), Positives = 127/255 (49%), Gaps = 1/255 (0%)
Frame = +1
Query: 16 LGSDDCGKDLNSVTNLQKKHNLLESDISSHQDRIDSFLQQADQFVHDNHFDADAIKKKQI 195
+ S D G D S +L KKH + +I++++ +D+ +QA + H ++ ++ +
Sbjct: 767 VSSSDVGHDEYSTQSLVKKHKDVAEEIANYRPTLDTLHEQASALPQE-HAESPDVRGRLS 825
Query: 196 EVCNRYSKLQEPLEKRKNKLNDAYKLHQFYRDADDEEDWIHEKEPIAGSTNVGRDLIGVQ 375
+ RY ++ E RK L D L++ + +AD E WI EKE + + L ++
Sbjct: 826 GIEERYKEVAELTRLRKQALQDTLALYKMFSEADACELWIDEKEQWLNNMQIPEKLEDLE 885
Query: 376 NLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANRDIEKKIDDMKNLWSDLKNKAD 555
+ + ++++ E+ R+ V ++++ H + ++I+ + D + WS + D
Sbjct: 886 VIQHRFESLEPEMNNQASRVAVVNQIARQLMHSGHPSEKEIKAQQDKLNTRWSQFRELVD 945
Query: 556 KRRQLLDDSLEAQQYLADASEAESWMREKEPLVGST-EFGKDEDSTEALLKKHDALMADI 732
+++ L +L Q Y + +E +SW+REK ++ ST + G D AL +K + D+
Sbjct: 946 RKKDALLSALSIQNYHLECNETKSWIREKTKVIESTQDLGNDLAGVMALQRKLTGMERDL 1005
Query: 733 EAYRSTIDSLRTQAD 777
A + + L+ +A+
Sbjct: 1006 VAIEAKLSDLQKEAE 1020
Score = 107 bits (266), Expect = 5e-23
Identities = 60/248 (24%), Positives = 126/248 (50%), Gaps = 1/248 (0%)
Frame = +1
Query: 22 SDDCGKDLNSVTNLQKKHNLLESDISSHQDRIDSFLQQADQFVHDNHFDADAIKKKQIEV 201
+ D G DL V LQ+K +E D+ + + ++ ++A++ ++ A AI + E+
Sbjct: 981 TQDLGNDLAGVMALQRKLTGMERDLVAIEAKLSDLQKEAEKLESEHPDQAQAILSRLAEI 1040
Query: 202 CNRYSKLQEPLEKRKNKLNDAYKLHQFYRDADDEEDWIHEKEPIAGSTNVGRDLIGVQNL 381
+ + +++ L+ R+ L +A KL QF RD DD + W+ + S ++ L + L
Sbjct: 1041 SDVWEEMKTTLKNREASLGEASKLQQFLRDLDDFQSWLSRTQTAIASEDMPNTLTEAEKL 1100
Query: 382 IKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYAN-RDIEKKIDDMKNLWSDLKNKADK 558
+ +H+ I+ E+ +E ++ + G+ + G A + +++ + W++L +
Sbjct: 1101 LTQHENIKNEIDNYEEDYQKMRDMGEMVTQGQTDAQYMFLRQRLQALDTGWNELHKMWEN 1160
Query: 559 RRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFGKDEDSTEALLKKHDALMADIEA 738
R+ LL S QQ+L D +AE+++ +E ++ TE + EA +KK + M ++A
Sbjct: 1161 RQNLLSQSHAYQQFLRDTKQAEAFLNNQEYVLAHTEMPTTLEGAEAAIKKQEDFMTTMDA 1220
Query: 739 YRSTIDSL 762
I+++
Sbjct: 1221 NEEKINAV 1228
Score = 105 bits (262), Expect = 2e-22
Identities = 59/281 (20%), Positives = 134/281 (47%), Gaps = 1/281 (0%)
Frame = +1
Query: 1 EVESQLGSDDCGKDLNSVTNLQKKHNLLESDISSHQDRIDSFLQQADQFVHDNHFDADAI 180
E E L + + L + +Q + LE ++++ R+ Q A Q +H H I
Sbjct: 867 EKEQWLNNMQIPEKLEDLEVIQHRFESLEPEMNNQASRVAVVNQIARQLMHSGHPSEKEI 926
Query: 181 KKKQIEVCNRYSKLQEPLEKRKNKLNDAYKLHQFYRDADDEEDWIHEKEPIAGST-NVGR 357
K +Q ++ R+S+ +E ++++K+ L A + ++ + ++ + WI EK + ST ++G
Sbjct: 927 KAQQDKLNTRWSQFRELVDRKKDALLSALSIQNYHLECNETKSWIREKTKVIESTQDLGN 986
Query: 358 DLIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANRDIEKKIDDMKNLWSD 537
DL GV L +K ++ ++ E ++ ++ E +K+ + + I ++ ++ ++W +
Sbjct: 987 DLAGVMALQRKLTGMERDLVAIEAKLSDLQKEAEKLESEHPDQAQAILSRLAEISDVWEE 1046
Query: 538 LKNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFGKDEDSTEALLKKHDA 717
+K R L ++ + QQ+L D + +SW+ + + S + E LL +H+
Sbjct: 1047 MKTTLKNREASLGEASKLQQFLRDLDDFQSWLSRTQTAIASEDMPNTLTEAEKLLTQHEN 1106
Query: 718 LMADIEAYRSTIDSLRTQADACKMQEAPVSDSYGKETVMAL 840
+ +I+ Y +R + + + ++ + AL
Sbjct: 1107 IKNEIDNYEEDYQKMRDMGEMVTQGQTDAQYMFLRQRLQAL 1147
Score = 104 bits (259), Expect = 4e-22
Identities = 64/232 (27%), Positives = 114/232 (49%), Gaps = 1/232 (0%)
Frame = +1
Query: 25 DDCGKDLNSVTNLQKKHNLLESDISSHQDRIDSFLQQADQFVHDNHFD-ADAIKKKQIEV 201
++ G+D N+V LQ+ H E DI + ++ + A + D AD I+K++ EV
Sbjct: 1830 EELGRDQNTVETLQRMHTTFEHDIQALGTQVRQLQEDAARLQAAYAGDKADDIQKRENEV 1889
Query: 202 CNRYSKLQEPLEKRKNKLNDAYKLHQFYRDADDEEDWIHEKEPIAGSTNVGRDLIGVQNL 381
+ L + E R+ +L D +F+ D W+ + + RD+ V+ L
Sbjct: 1890 LEAWKSLLDACESRRVRLVDTGDKFRFFSMVRDLMLWMEDVIRQIEAQEKPRDVSSVELL 1949
Query: 382 IKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANRDIEKKIDDMKNLWSDLKNKADKR 561
+ HQ I+AE+ G+ ++ HYA+ +I++K+ + ++ +K + R
Sbjct: 1950 MNNHQGIKAEIDARNDSFTTCIELGKSLLARKHYASEEIKEKLLQLTEKRKEMIDKWEDR 2009
Query: 562 RQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFGKDEDSTEALLKKHDA 717
+ L LE Q+ DAS AE+W+ +EP + S E G+ D E L+K+H+A
Sbjct: 2010 WEWLRLILEVHQFSRDASVAEAWLLGQEPYLSSREIGQSVDEVEKLIKRHEA 2061
Score = 92.0 bits (227), Expect = 2e-18
Identities = 54/242 (22%), Positives = 119/242 (49%)
Frame = +1
Query: 67 KKHNLLESDISSHQDRIDSFLQQADQFVHDNHFDADAIKKKQIEVCNRYSKLQEPLEKRK 246
KK + + +++++I++ ++ + V D + ++D I++K + +R+ K +E +
Sbjct: 1209 KKQEDFMTTMDANEEKINAVVETGRRLVSDGNINSDRIQEKVDSIDDRHRKNRETASELL 1268
Query: 247 NKLNDAYKLHQFYRDADDEEDWIHEKEPIAGSTNVGRDLIGVQNLIKKHQAIQAEVTGHE 426
+L D L +F +D + WI+EK A + + + + KHQA AE+ ++
Sbjct: 1269 MRLKDNRDLQKFLQDCQELSLWINEKMLTAQDMSYD-EARNLHSKWLKHQAFMAELASNK 1327
Query: 427 PRILEVCNEGQKMIDGNHYANRDIEKKIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYLA 606
+ ++ EG ++I +++K+ + +W L++ + Q L D+ +A+ +
Sbjct: 1328 EWLDKIEKEGMQLISEKPETEAVVKEKLTGLHKMWEVLESTTQTKAQRLFDANKAELFTQ 1387
Query: 607 DASEAESWMREKEPLVGSTEFGKDEDSTEALLKKHDALMADIEAYRSTIDSLRTQADACK 786
++ + W+ E + S ++GK S LLKK L +E + I+ L++QA A
Sbjct: 1388 SCADLDKWLHGLESQIQSDDYGKHLTSVNILLKKQQMLENQMEVRKKEIEELQSQAQALS 1447
Query: 787 MQ 792
+
Sbjct: 1448 QE 1449
Score = 79.3 bits (194), Expect = 1e-14
Identities = 52/167 (31%), Positives = 82/167 (49%), Gaps = 4/167 (2%)
Frame = +1
Query: 244 KNKLNDAYKLHQ----FYRDADDEEDWIHEKEPIAGSTNVGRDLIGVQNLIKKHQAIQAE 411
+N+L KL Q F R A E W+ E + + N G DL V+ KKH+AI+ +
Sbjct: 411 RNELIRQEKLEQLARRFDRKAAMRETWLSENQRLVSQDNFGFDLPAVEAATKKHEAIETD 470
Query: 412 VTGHEPRILEVCNEGQKMIDGNHYANRDIEKKIDDMKNLWSDLKNKADKRRQLLDDSLEA 591
+ +E R+ V +++ N++ + I + D++ LW L RRQ L+ +L
Sbjct: 471 IAAYEERVQAVVAVARELEAENYHDIKRITARKDNVIRLWEYLLELLRARRQRLEMNLGL 530
Query: 592 QQYLADASEAESWMREKEPLVGSTEFGKDEDSTEALLKKHDALMADI 732
Q+ + WM E + LV S ++GK E LL+KH + ADI
Sbjct: 531 QKIFQEMLYIMDWMDEMKVLVLSQDYGKHLLGVEDLLQKHTLVEADI 577
Score = 68.6 bits (166), Expect = 2e-11
Identities = 35/144 (24%), Positives = 74/144 (51%)
Frame = +1
Query: 1 EVESQLGSDDCGKDLNSVTNLQKKHNLLESDISSHQDRIDSFLQQADQFVHDNHFDADAI 180
+V Q+ + + +D++SV L H ++++I + D + ++ + H+ ++ I
Sbjct: 1929 DVIRQIEAQEKPRDVSSVELLMNNHQGIKAEIDARNDSFTTCIELGKSLLARKHYASEEI 1988
Query: 181 KKKQIEVCNRYSKLQEPLEKRKNKLNDAYKLHQFYRDADDEEDWIHEKEPIAGSTNVGRD 360
K+K +++ + ++ + E R L ++HQF RDA E W+ +EP S +G+
Sbjct: 1989 KEKLLQLTEKRKEMIDKWEDRWEWLRLILEVHQFSRDASVAEAWLLGQEPYLSSREIGQS 2048
Query: 361 LIGVQNLIKKHQAIQAEVTGHEPR 432
+ V+ LIK+H+A + + R
Sbjct: 2049 VDEVEKLIKRHEAFEKSAATWDER 2072
Score = 58.5 bits (140), Expect = 2e-08
Identities = 64/263 (24%), Positives = 104/263 (39%), Gaps = 21/263 (7%)
Frame = +1
Query: 37 KDLNSVTNLQKKHNLLESDISSHQDRIDSFLQQADQFVHDNHFDADAIKKKQIEVCNRYS 216
K N+ NLQ NL E + + L D V +H D +I + + +S
Sbjct: 226 KKSNAHYNLQNAFNLAEQHLG-----LTKLLDPEDISV--DHPDEKSIITYVVTYYHYFS 278
Query: 217 KLQEPLEKRK-------NKLNDAYKLHQFYRDADDEEDWIHEKEPIAGSTNVGRDLIGVQ 375
K++ + K N + + ++ A D +WI + I + L+GVQ
Sbjct: 279 KMKALAVEGKRIGKVLDNAIETEKMIEKYESLASDLLEWIEQTIIILNNRKFANSLVGVQ 338
Query: 376 NLIKK---HQAIQAEVTGHEPRILEVC--NEGQKMIDGNHYANRDIEKK-IDDMKNLWSD 537
++ ++ ++ E LEV KM N E K I D+ W
Sbjct: 339 QQLQAFNTYRTVEKPPKFTEKGNLEVLLFTIQSKMRANNQKVYMpreGKLISDINKAWER 398
Query: 538 LKNKADKRRQLLDDSLEAQQYLAD--------ASEAESWMREKEPLVGSTEFGKDEDSTE 693
L+ +R L + L Q+ L A+ E+W+ E + LV FG D + E
Sbjct: 399 LEKAEHERELALRNELIRQEKLEQLARRFDRKAAMRETWLSENQRLVSQDNFGFDLPAVE 458
Query: 694 ALLKKHDALMADIEAYRSTIDSL 762
A KKH+A+ DI AY + ++
Sbjct: 459 AATKKHEAIETDIAAYEERVQAV 481
>sp|Q00963|SPTCB_DROME Spectrin beta chain
Length = 2291
Score = 175 bits (444), Expect = 1e-43
Identities = 90/271 (33%), Positives = 162/271 (59%), Gaps = 5/271 (1%)
Frame = +1
Query: 1 EVESQLGSDDCGKDLNSVTNLQKKHNLLESDISSHQDRIDSFLQQADQFVHDNH-----F 165
E++ L +DD GK L V +L +KH+L+E+DI+ +R+ +Q + +F+ D+
Sbjct: 542 EIKQLLMTDDYGKHLMGVEDLLQKHSLVEADINILGERVKVVVQNSQKFLSDDPESYKPC 601
Query: 166 DADAIKKKQIEVCNRYSKLQEPLEKRKNKLNDAYKLHQFYRDADDEEDWIHEKEPIAGST 345
D + I + ++ + Y++L +R+++L ++ KL QFY D DEE+WI EKE I +
Sbjct: 602 DPEIIVSRVQQLEDAYAELVRLAVERRSRLEESRKLWQFYWDTADEENWIKEKEQIVSTD 661
Query: 346 NVGRDLIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANRDIEKKIDDMKN 525
VG DL V ++ KH+A+++E+T H+P++ V G ++I H+ I+ ++ ++ N
Sbjct: 662 EVGHDLTTVNLMLSKHKALESEITSHDPQLQNVAKVGSELITEGHFGADRIKDRLKEILN 721
Query: 526 LWSDLKNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFGKDEDSTEALLK 705
W L + RRQ L++++E Q ADA + ++WM + +V S + G+DE + ++LLK
Sbjct: 722 KWDHLLDLTKYRRQRLENAVEYFQLFADADDVDNWMLDTLRIVSSEDVGRDEANVQSLLK 781
Query: 706 KHDALMADIEAYRSTIDSLRTQADACKMQEA 798
KH + +++ Y ID+L QA++ K+ EA
Sbjct: 782 KHKDVADELKNYAEVIDALHKQAESLKLNEA 812
Score = 167 bits (423), Expect = 3e-41
Identities = 93/257 (36%), Positives = 142/257 (55%), Gaps = 3/257 (1%)
Frame = +1
Query: 1 EVESQLGSDDCGKDLNSVTNLQKKHNLLESDIS---SHQDRIDSFLQQADQFVHDNHFDA 171
++E Q+ S D DL SV L +K ++++ ++ + ID + + V + +
Sbjct: 1398 DLEKQIVSGDTANDLTSVNILMQKQQVIQTQMAVKARQVEEIDKQTEYLQKTVPEEKIEP 1457
Query: 172 DAIKKKQIEVCNRYSKLQEPLEKRKNKLNDAYKLHQFYRDADDEEDWIHEKEPIAGSTNV 351
+KK V R+ K++ PL +R+ L + QF RD +DE+ WI EK P+A S +
Sbjct: 1458 IVVKKTA--VLERFEKIKAPLLERQKALEKKKEAFQFCRDVEDEKLWIDEKLPVANSPDY 1515
Query: 352 GRDLIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANRDIEKKIDDMKNLW 531
G L V L KK+Q++ E+ HEPRI +CN G+K+ID H + E I D+ W
Sbjct: 1516 GNSLFNVHVLKKKNQSLATEIDNHEPRINAICNNGRKLIDEGHEDAKKFEALISDLTQKW 1575
Query: 532 SDLKNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFGKDEDSTEALLKKH 711
+LK+ + RR+ L +S + QQY DA EAESWM E+E + + GKDE S + L+KKH
Sbjct: 1576 QELKDAIENRRKHLLESEKVQQYFFDAQEAESWMSEQELYMMVEDRGKDEISAQNLMKKH 1635
Query: 712 DALMADIEAYRSTIDSL 762
+ L +E Y +TI L
Sbjct: 1636 ENLEQSVEDYANTIRQL 1652
Score = 134 bits (337), Expect = 3e-31
Identities = 72/270 (26%), Positives = 143/270 (52%)
Frame = +1
Query: 1 EVESQLGSDDCGKDLNSVTNLQKKHNLLESDISSHQDRIDSFLQQADQFVHDNHFDADAI 180
E E + +D+ G DL +V + KH LES+I+SH ++ + + + + + HF AD I
Sbjct: 653 EKEQIVSTDEVGHDLTTVNLMLSKHKALESEITSHDPQLQNVAKVGSELITEGHFGADRI 712
Query: 181 KKKQIEVCNRYSKLQEPLEKRKNKLNDAYKLHQFYRDADDEEDWIHEKEPIAGSTNVGRD 360
K + E+ N++ L + + R+ +L +A + Q + DADD ++W+ + I S +VGRD
Sbjct: 713 KDRLKEILNKWDHLLDLTKYRRQRLENAVEYFQLFADADDVDNWMLDTLRIVSSEDVGRD 772
Query: 361 LIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANRDIEKKIDDMKNLWSDL 540
VQ+L+KKH+ + E+ + +++ ++ + + N +++K+++ + N + +L
Sbjct: 773 EANVQSLLKKHKDVADELKNYA-EVIDALHKQAESLKLNEAEKANVDKRLEAIDNRYKEL 831
Query: 541 KNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFGKDEDSTEALLKKHDAL 720
A R+Q L D+L + +++A E W++EK ++ + GKD + E + + +
Sbjct: 832 TELAKLRKQRLLDALSLYKLMSEADGVEQWIKEKTKMLDTMTPGKDIEDVEIMKHRFEGF 891
Query: 721 MADIEAYRSTIDSLRTQADACKMQEAPVSD 810
++ A S + + A E P SD
Sbjct: 892 DKEMNANASRVAVVNQLARQLLHVEHPNSD 921
Score = 117 bits (293), Expect = 4e-26
Identities = 81/272 (29%), Positives = 131/272 (48%), Gaps = 2/272 (0%)
Frame = +1
Query: 1 EVESQLGSDDCGKDLNSVTNLQKKHNLLESDISSHQDRIDSFLQQADQFVHDNHFDADAI 180
E E + +D GKD S NL KKH LE + + + I + A QF D+ DA+
Sbjct: 1611 EQELYMMVEDRGKDEISAQNLMKKHENLEQSVEDYANTIRQLGEVARQFSGDDISSGDAV 1670
Query: 181 KKKQIEVCNRYSKLQEPLEKRKNKLNDAYKLHQFYRDADDEEDWIHEKEPIAGSTNVGRD 360
KQ ++ Y+ L++ +R+ +LN+A +L R+ DD E WI ++E +AGS +G+D
Sbjct: 1671 AVKQSQLDKLYAGLKDLAGERRARLNEALQLFMLSREVDDLEQWITDREVVAGSQELGQD 1730
Query: 361 LIGVQNLIKKHQ--AIQAEVTGHEPRILEVCNEGQKMIDGNHYANRDIEKKIDDMKNLWS 534
V L ++ A E G E R+ +V +I H + I + D++ W
Sbjct: 1731 FDHVTLLSERFNEFARDTEAVGGE-RVAKVNGIADNLIQAGHSDSATIAEWKDNLNESWQ 1789
Query: 535 DLKNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFGKDEDSTEALLKKHD 714
DL + R Q+L S E ++ D + + EK+ V S E G+D S L +KH
Sbjct: 1790 DLLELIETRTQMLAASRELHKFFHDCKDVLGRILEKQHGV-SDELGRDAGSVSTLQRKHY 1848
Query: 715 ALMADIEAYRSTIDSLRTQADACKMQEAPVSD 810
+ D+ S + + Q ++ K+Q+A D
Sbjct: 1849 NFLQDLITLYSQVQQI--QEESAKLQDAYAGD 1878
Score = 114 bits (285), Expect = 3e-25
Identities = 64/240 (26%), Positives = 127/240 (52%), Gaps = 1/240 (0%)
Frame = +1
Query: 22 SDDCGKDLNSVTNLQKKHNLLESDISSHQDRIDSFLQQADQFVHDNHFDADAIKKKQIEV 201
S D G L +V L+KK+ L ++I +H+ RI++ + + + H DA + ++
Sbjct: 1512 SPDYGNSLFNVHVLKKKNQSLATEIDNHEPRINAICNNGRKLIDEGHEDAKKFEALISDL 1571
Query: 202 CNRYSKLQEPLEKRKNKLNDAYKLHQFYRDADDEEDWIHEKEPIAGSTNVGRDLIGVQNL 381
++ +L++ +E R+ L ++ K+ Q++ DA + E W+ E+E + G+D I QNL
Sbjct: 1572 TQKWQELKDAIENRRKHLLESEKVQQYFFDAQEAESWMSEQELYMMVEDRGKDEISAQNL 1631
Query: 382 IKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANRD-IEKKIDDMKNLWSDLKNKADK 558
+KKH+ ++ V + I ++ E + G+ ++ D + K + L++ LK+ A +
Sbjct: 1632 MKKHENLEQSVEDYANTIRQL-GEVARQFSGDDISSGDAVAVKQSQLDKLYAGLKDLAGE 1690
Query: 559 RRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFGKDEDSTEALLKKHDALMADIEA 738
RR L+++L+ + + E W+ ++E + GS E G+D D L ++ + D EA
Sbjct: 1691 RRARLNEALQLFMLSREVDDLEQWITDREVVAGSQELGQDFDHVTLLSERFNEFARDTEA 1750
Score = 112 bits (281), Expect = 1e-24
Identities = 73/258 (28%), Positives = 129/258 (50%), Gaps = 5/258 (1%)
Frame = +1
Query: 4 VESQLG-SDDCGKDLNSVTNLQKKHNLLESDISSHQDRIDSFLQQA----DQFVHDNHFD 168
+E Q G SD+ G+D SV+ LQ+KH D+ + ++ +++ D + D
Sbjct: 1823 LEKQHGVSDELGRDAGSVSTLQRKHYNFLQDLITLYSQVQQIQEESAKLQDAYAGDK--- 1879
Query: 169 ADAIKKKQIEVCNRYSKLQEPLEKRKNKLNDAYKLHQFYRDADDEEDWIHEKEPIAGSTN 348
A I ++ EV + + LQ + RK KL D L +F+ W+ + ++
Sbjct: 1880 AKEITNREQEVLHAWDNLQAMCDARKQKLADTGDLFRFFNMVRILMIWMEDLVRQMNTSE 1939
Query: 349 VGRDLIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANRDIEKKIDDMKNL 528
RD+ GV+ L+ HQ+++AE+ E + G++++ NHYA+ DI+ ++ + N
Sbjct: 1940 KPRDVSGVELLMNNHQSLKAEIDTREDNFGACISLGKELLTRNHYASADIKDRLMTLSNS 1999
Query: 529 WSDLKNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFGKDEDSTEALLKK 708
+ L + ++R + L LE Q+ DA+ AE+W+ +EP + S+E G D E L+KK
Sbjct: 2000 RNALLRRWEERWENLQLILEVYQFARDAAVAEAWLIAQEPYLLSSELGHTIDEVENLIKK 2059
Query: 709 HDALMADIEAYRSTIDSL 762
H+A A +L
Sbjct: 2060 HEAFEKSAAAQEERFSAL 2077
Score = 110 bits (274), Expect = 6e-24
Identities = 65/252 (25%), Positives = 135/252 (53%), Gaps = 5/252 (1%)
Frame = +1
Query: 1 EVESQLGSDDCGKDLNSVTNLQKKHNLLESDISSHQDRIDSFLQQADQFVHDNHFDADAI 180
E + + D+ G DL +V KKH +E+DI ++++R+ + + D+ + + D I
Sbjct: 436 ENQRLVSQDNFGFDLAAVEAAAKKHEAIETDIFAYEERVQAVVAVCDELESERYHDVKRI 495
Query: 181 KKKQIEVCNRYSKLQEPLEKRKNKLNDAYKLHQFYRDADDEEDWIHEKEPIAGSTNVGRD 360
++ V ++ L E L R+ +L + +L Q +++ D + E + + + + G+
Sbjct: 496 LLRKDNVMRLWTYLLELLRARRMRLEISLQLQQNFQEMLYILDNMEEIKQLLMTDDYGKH 555
Query: 361 LIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMI--DGNHYANRD---IEKKIDDMKN 525
L+GV++L++KH ++A++ R+ V QK + D Y D I ++ +++
Sbjct: 556 LMGVEDLLQKHSLVEADINILGERVKVVVQNSQKFLSDDPESYKPCDPEIIVSRVQQLED 615
Query: 526 LWSDLKNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFGKDEDSTEALLK 705
+++L A +RR L++S + Q+ D ++ E+W++EKE +V + E G D + +L
Sbjct: 616 AYAELVRLAVERRSRLEESRKLWQFYWDTADEENWIKEKEQIVSTDEVGHDLTTVNLMLS 675
Query: 706 KHDALMADIEAY 741
KH AL ++I ++
Sbjct: 676 KHKALESEITSH 687
Score = 100 bits (248), Expect = 7e-21
Identities = 60/271 (22%), Positives = 137/271 (50%), Gaps = 4/271 (1%)
Frame = +1
Query: 22 SDDCGKDLNSVTNLQKKHNLLESDISSHQDRIDSFLQQADQFVHDNHFDADAIKKKQIEV 201
+D DL V LQ++ + ++ D+++ Q ++ S ++A+ ++ +A I+++ ++
Sbjct: 978 TDSLEMDLTGVMTLQRRLSGMDRDLAAIQAKLSSLEREANSIEDEHPEEAKIIRERIAQI 1037
Query: 202 CNRYSKLQEPLEKRKNKLNDAYKLHQFYRDADDEEDWIHEKEPIAGSTNVGRDLIGVQNL 381
+ +L + L++R +KL +A LH+F RD D + W+ + + S + L + L
Sbjct: 1038 ELIWEQLTQMLKERDSKLEEAGDLHRFLRDLDHFQTWLTKTQTDVASEDTPTSLPEAEKL 1097
Query: 382 IKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANRD----IEKKIDDMKNLWSDLKNK 549
+ +HQ+I+ E+ + + G+++ ++ + ++++ +K+ W +L
Sbjct: 1098 LNQHQSIREEIDNYTEDYKNMMEYGERLTSEGSTSDDPQYMFLRERLNALKDGWEELHQM 1157
Query: 550 ADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFGKDEDSTEALLKKHDALMAD 729
+ R+ LL SL+ Q + DA + E + ++E + + + + E LK+H+A +
Sbjct: 1158 WENRQVLLSQSLDQQLFNRDARQTEVLLSQQEHFLSKDDTPVNLEQAENQLKRHEAFLTT 1217
Query: 730 IEAYRSTIDSLRTQADACKMQEAPVSDSYGK 822
+EA I++L AD ++ +D GK
Sbjct: 1218 MEANDDKINTLLQVADTLVEKDHFDADKIGK 1248
Score = 98.6 bits (244), Expect = 2e-20
Identities = 60/256 (23%), Positives = 128/256 (50%), Gaps = 1/256 (0%)
Frame = +1
Query: 16 LGSDDCGKDLNSVTNLQKKHNLLESDISSHQDRIDSFLQQADQFVHDNHFDADAIKKKQI 195
+ S+D G+D +V +L KKH + ++ ++ + ID+ +QA+ + N + + K+
Sbjct: 764 VSSEDVGRDEANVQSLLKKHKDVADELKNYAEVIDALHKQAES-LKLNEAEKANVDKRLE 822
Query: 196 EVCNRYSKLQEPLEKRKNKLNDAYKLHQFYRDADDEEDWIHEKEPIAGSTNVGRDLIGVQ 375
+ NRY +L E + RK +L DA L++ +AD E WI EK + + G+D+ V+
Sbjct: 823 AIDNRYKELTELAKLRKQRLLDALSLYKLMSEADGVEQWIKEKTKMLDTMTPGKDIEDVE 882
Query: 376 NLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANRDIEKKIDDMKNLWSDLKNKAD 555
+ + + E+ + R+ V ++++ H + +I ++ + + WS L+ KA+
Sbjct: 883 IMKHRFEGFDKEMNANASRVAVVNQLARQLLHVEHPNSDEILERQNHLNQEWSTLREKAE 942
Query: 556 KRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTE-FGKDEDSTEALLKKHDALMADI 732
+ L + Q + + E SW+ +K+ ++ T+ D L ++ + D+
Sbjct: 943 AKMDDLKSAHGVQTFYIECRETISWIEDKKRILTETDSLEMDLTGVMTLQRRLSGMDRDL 1002
Query: 733 EAYRSTIDSLRTQADA 780
A ++ + SL +A++
Sbjct: 1003 AAIQAKLSSLEREANS 1018
Score = 93.6 bits (231), Expect = 6e-19
Identities = 57/257 (22%), Positives = 115/257 (44%)
Frame = +1
Query: 7 ESQLGSDDCGKDLNSVTNLQKKHNLLESDISSHQDRIDSFLQQADQFVHDNHFDADAIKK 186
E L DD +L N K+H + + ++ D+I++ LQ AD V +HFDAD I K
Sbjct: 1189 EHFLSKDDTPVNLEQAENQLKRHEAFLTTMEANDDKINTLLQVADTLVEKDHFDADKIGK 1248
Query: 187 KQIEVCNRYSKLQEPLEKRKNKLNDAYKLHQFYRDADDEEDWIHEKEPIAGSTNVGRDLI 366
+ + R ++ + KL + KLH+F +D ++ +W+ EK + + R
Sbjct: 1249 RAENITGRRDDNRQRALDQHEKLKNQVKLHEFLQDLEELAEWVQEKYATSQDESY-RSAK 1307
Query: 367 GVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANRDIEKKIDDMKNLWSDLKN 546
+ + +HQA +AE+ ++ R+ E Q++ IE K+ ++ + DL+
Sbjct: 1308 TIHSKWTRHQAFEAEIAANKERLFEAEKSAQELSKEKPEFKDVIEPKLKELAKQFDDLEV 1367
Query: 547 KADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFGKDEDSTEALLKKHDALMA 726
++ +L D+ + +S++ + E + S + D S L++K +
Sbjct: 1368 HTKEKGAMLFDANREVLVQQTCDDIDSYITDLEKQIVSGDTANDLTSVNILMQKQQVIQT 1427
Query: 727 DIEAYRSTIDSLRTQAD 777
+ ++ + Q +
Sbjct: 1428 QMAVKARQVEEIDKQTE 1444
Score = 86.3 bits (212), Expect = 1e-16
Identities = 50/237 (21%), Positives = 114/237 (48%), Gaps = 1/237 (0%)
Frame = +1
Query: 34 GKDLNSVTNLQKKHNLLESDISSHQDRIDSFLQQADQFVHDNHFDADAIKKKQIEVCNRY 213
GKD+ V ++ + + +++++ R+ Q A Q +H H ++D I ++Q + +
Sbjct: 875 GKDIEDVEIMKHRFEGFDKEMNANASRVAVVNQLARQLLHVEHPNSDEILERQNHLNQEW 934
Query: 214 SKLQEPLEKRKNKLNDAYKLHQFYRDADDEEDWIHEKEPIAGSTN-VGRDLIGVQNLIKK 390
S L+E E + + L A+ + FY + + WI +K+ I T+ + DL GV L ++
Sbjct: 935 STLREKAEAKMDDLKSAHGVQTFYIECRETISWIEDKKRILTETDSLEMDLTGVMTLQRR 994
Query: 391 HQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANRDIEKKIDDMKNLWSDLKNKADKRRQL 570
+ ++ + ++ + E + D + + I ++I ++ +W L +R
Sbjct: 995 LSGMDRDLAAIQAKLSSLEREANSIEDEHPEEAKIIRERIAQIELIWEQLTQMLKERDSK 1054
Query: 571 LDDSLEAQQYLADASEAESWMREKEPLVGSTEFGKDEDSTEALLKKHDALMADIEAY 741
L+++ + ++L D ++W+ + + V S + E LL +H ++ +I+ Y
Sbjct: 1055 LEEAGDLHRFLRDLDHFQTWLTKTQTDVASEDTPTSLPEAEKLLNQHQSIREEIDNY 1111
Score = 71.2 bits (173), Expect = 3e-12
Identities = 48/155 (30%), Positives = 78/155 (50%), Gaps = 3/155 (1%)
Frame = +1
Query: 277 QFYRDADDEEDWIHEKEPIAGSTNVGRDLIGVQNLIKKHQAIQAEVTGHEPR---ILEVC 447
+F R A E W+ E + + N G DL V+ KKH+AI+ ++ +E R ++ VC
Sbjct: 422 RFDRKASMRETWLSENQRLVSQDNFGFDLAAVEAAAKKHEAIETDIFAYEERVQAVVAVC 481
Query: 448 NEGQKMIDGNHYANRDIEKKIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYLADASEAES 627
+E + + H R + +K D++ LW+ L RR L+ SL+ QQ +
Sbjct: 482 DELES--ERYHDVKRILLRK-DNVMRLWTYLLELLRARRMRLEISLQLQQNFQEMLYILD 538
Query: 628 WMREKEPLVGSTEFGKDEDSTEALLKKHDALMADI 732
M E + L+ + ++GK E LL+KH + ADI
Sbjct: 539 NMEEIKQLLMTDDYGKHLMGVEDLLQKHSLVEADI 573
Score = 63.2 bits (152), Expect = 9e-10
Identities = 43/274 (15%), Positives = 115/274 (41%), Gaps = 4/274 (1%)
Frame = +1
Query: 1 EVESQLGSDDCGKDLNSVTNLQKKHNLLESDISSHQDRIDSFLQQADQFVHDNHFDADA- 177
+ ++ + S+D L L +H + +I ++ + + ++ ++ + D
Sbjct: 1077 KTQTDVASEDTPTSLPEAEKLLNQHQSIREEIDNYTEDYKNMMEYGERLTSEGSTSDDPQ 1136
Query: 178 ---IKKKQIEVCNRYSKLQEPLEKRKNKLNDAYKLHQFYRDADDEEDWIHEKEPIAGSTN 348
++++ + + + +L + E R+ L+ + F RDA E + ++E +
Sbjct: 1137 YMFLRERLNALKDGWEELHQMWENRQVLLSQSLDQQLFNRDARQTEVLLSQQEHFLSKDD 1196
Query: 349 VGRDLIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANRDIEKKIDDMKNL 528
+L +N +K+H+A + ++ +I + +++ +H+ I K+ +++
Sbjct: 1197 TPVNLEQAENQLKRHEAFLTTMEANDDKINTLLQVADTLVEKDHFDADKIGKRAENITGR 1256
Query: 529 WSDLKNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFGKDEDSTEALLKK 708
D + +A + + L + ++ ++L D E W++EK E + + + +
Sbjct: 1257 RDDNRQRALDQHEKLKNQVKLHEFLQDLEELAEWVQEKY-ATSQDESYRSAKTIHSKWTR 1315
Query: 709 HDALMADIEAYRSTIDSLRTQADACKMQEAPVSD 810
H A A+I A + + A ++ D
Sbjct: 1316 HQAFEAEIAANKERLFEAEKSAQELSKEKPEFKD 1349
Score = 57.0 bits (136), Expect = 6e-08
Identities = 64/257 (24%), Positives = 99/257 (38%), Gaps = 22/257 (8%)
Frame = +1
Query: 73 HNLLES-DISSHQDRIDSFLQQADQFVHDNHFDADAIKKKQIEVCNRYSKLQEPLEKRKN 249
HNL + D++ + + L D FV H D +I + + +SKL++ + K
Sbjct: 228 HNLNNAFDVAEDKLGLAKLLDAEDVFVE--HPDEKSIITYVVTYYHYFSKLKQETVQGKR 285
Query: 250 -------KLNDAYKLHQFYRDADDEEDWIHEKEPIAGSTNVGRDLIGVQNLIKK---HQA 399
+ + +H + D WI G L GVQ + + ++
Sbjct: 286 IGKVVGIAMENDKMVHDYENFTSDLLKWIETTIQSLGEREFENSLAGVQGQLAQFSNYRT 345
Query: 400 IQAEVTGHEPRILEVC--NEGQKMIDGNHYANRDIE-KKIDDMKNLWSDLKNKADKRRQL 570
I+ E LEV KM N E K I D+ W L+ +R
Sbjct: 346 IEKPPKFVEKGNLEVLLFTLQSKMRANNQKPYTPKEGKMISDINKAWERLEKAEHERELA 405
Query: 571 LDDSLEAQQYLAD--------ASEAESWMREKEPLVGSTEFGKDEDSTEALLKKHDALMA 726
L + L Q+ L AS E+W+ E + LV FG D + EA KKH+A+
Sbjct: 406 LREELIRQEKLEQLAARFDRKASMRETWLSENQRLVSQDNFGFDLAAVEAAAKKHEAIET 465
Query: 727 DIEAYRSTIDSLRTQAD 777
DI AY + ++ D
Sbjct: 466 DIFAYEERVQAVVAVCD 482
>sp|Q9QWN8|SPTN2_RAT Spectrin beta chain, brain 2 (Spectrin, non-erythroid beta chain 2)
(Beta-III spectrin) (SPNB-3) (Beta SpIII sigma 1)
(Spectrin-like protein GTRAP41)
Length = 2388
Score = 154 bits (388), Expect = 4e-37
Identities = 91/268 (33%), Positives = 151/268 (56%)
Frame = +1
Query: 4 VESQLGSDDCGKDLNSVTNLQKKHNLLESDISSHQDRIDSFLQQADQFVHDNHFDADAIK 183
+++QL SDD GKDL SV L KK +LE +++ + +++ QA ++ A ++
Sbjct: 1402 LQAQLHSDDYGKDLTSVNILLKKQQMLEREMAVREKEVEAIQAQAKALAQEDQ-SAGEVE 1460
Query: 184 KKQIEVCNRYSKLQEPLEKRKNKLNDAYKLHQFYRDADDEEDWIHEKEPIAGSTNVGRDL 363
+ V ++ L +P++ R +L + + HQF+RD +DE W+ E+ P+A S G+DL
Sbjct: 1461 RTSRAVEEKFRALCQPMKDRCRRLQASREQHQFHRDVEDEILWVTERLPMASSLEHGKDL 1520
Query: 364 IGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANRDIEKKIDDMKNLWSDLK 543
VQ L+KK+Q +Q E+ GHEPRI ++ E Q+ + G A ++ +++ +W L
Sbjct: 1521 PSVQLLMKKNQTLQKEIQGHEPRIADL-KERQRTL-GTAAAGPELA----ELQEMWKRLS 1574
Query: 544 NKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFGKDEDSTEALLKKHDALM 723
++ + R + L+++L AQQ+ DA+EAE+WM E+E + E KDE S +A +KKH L
Sbjct: 1575 HELELRGKRLEEALRAQQFYRDAAEAEAWMGEQELHMMGQEKAKDELSAQAEVKKHQVLE 1634
Query: 724 ADIEAYRSTIDSLRTQADACKMQEAPVS 807
+ Y TI L + E P S
Sbjct: 1635 QALADYAQTIKQLAASSQDMIDHEHPES 1662
Score = 139 bits (349), Expect = 1e-32
Identities = 80/264 (30%), Positives = 139/264 (52%), Gaps = 4/264 (1%)
Frame = +1
Query: 1 EVESQLGSDDCGKDLNSVTNLQKKHNLLESDISSHQDRIDSFLQQADQFVHDNH----FD 168
E++ +L S D GK L V +L + H L+E+DI+ +R+ + A +F D
Sbjct: 549 EMKGRLQSQDLGKHLAGVEDLLQLHELVEADIAVQAERVRAVSASALRFCDPGKEYRPCD 608
Query: 169 ADAIKKKQIEVCNRYSKLQEPLEKRKNKLNDAYKLHQFYRDADDEEDWIHEKEPIAGSTN 348
+ ++ + Y L E R+ +L ++ +L +F + + E W+ E++ + S
Sbjct: 609 PQLVSERVATLEQSYEALCELAATRRARLEESRRLWRFLWEVGEAEAWVREQQHLLASAE 668
Query: 349 VGRDLIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANRDIEKKIDDMKNL 528
GRDL GV L+ KH A++ E++G + +GQ+++ H + +++
Sbjct: 669 TGRDLTGVLRLLNKHTALRGEMSGRLGPLKLTLEQGQQLVAEGHPGANQASTRAAELQAQ 728
Query: 529 WSDLKNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFGKDEDSTEALLKK 708
W L+ A++R Q L + Q+ ADA++ E+W+ + LV S E G DE ST+AL ++
Sbjct: 729 WERLEALAEERAQRLAQAASLYQFQADANDMEAWLVDALRLVSSPEVGHDEFSTQALARQ 788
Query: 709 HDALMADIEAYRSTIDSLRTQADA 780
H AL +I A+R T+D+LR QA A
Sbjct: 789 HRALEEEIRAHRPTLDALREQAAA 812
Score = 104 bits (259), Expect = 4e-22
Identities = 69/249 (27%), Positives = 112/249 (44%), Gaps = 1/249 (0%)
Frame = +1
Query: 34 GKDLNSVTNLQKKHNLLESDISSHQDRIDSFLQQADQFVHDNHFDADAIKKKQIEVCNRY 213
GKDL SV L KK+ L+ +I H+ RI AD A + E+ +
Sbjct: 1517 GKDLPSVQLLMKKNQTLQKEIQGHEPRI------ADLKERQRTLGTAAAGPELAELQEMW 1570
Query: 214 SKLQEPLEKRKNKLNDAYKLHQFYRDADDEEDWIHEKEPIAGSTNVGRDLIGVQNLIKKH 393
+L LE R +L +A + QFYRDA + E W+ E+E +D + Q +KKH
Sbjct: 1571 KRLSHELELRGKRLEEALRAQQFYRDAAEAEAWMGEQELHMMGQEKAKDELSAQAEVKKH 1630
Query: 394 QAIQAEVTGHEPRILEVCNEGQKMIDGNHYANRDIEKKIDDMKNLWSDLKNKADKRRQLL 573
Q ++ + + I ++ Q MID H + + + + L++ LK A +RR+ L
Sbjct: 1631 QVLEQALADYAQTIKQLAASSQDMIDHEHPESTRLTIRQAQVDKLYAGLKELAGERRERL 1690
Query: 574 DDSLEAQQYLADASEAESWMREKEPLVGSTEFGKDEDSTEALLKKHDALMADIEAY-RST 750
+ L Q + + E W++E+E + S E G+D + L K D +
Sbjct: 1691 QEHLRLCQLRRELDDLEQWIQEREVVAASHELGQDYEHVTMLRDKFREFSRDTSTIGQER 1750
Query: 751 IDSLRTQAD 777
+DS A+
Sbjct: 1751 VDSANALAN 1759
Score = 102 bits (253), Expect = 2e-21
Identities = 62/270 (22%), Positives = 124/270 (45%)
Frame = +1
Query: 1 EVESQLGSDDCGKDLNSVTNLQKKHNLLESDISSHQDRIDSFLQQADQFVHDNHFDADAI 180
E + L S + G+DL V L KH L ++S + L+Q Q V + H A+
Sbjct: 659 EQQHLLASAETGRDLTGVLRLLNKHTALRGEMSGRLGPLKLTLEQGQQLVAEGHPGANQA 718
Query: 181 KKKQIEVCNRYSKLQEPLEKRKNKLNDAYKLHQFYRDADDEEDWIHEKEPIAGSTNVGRD 360
+ E+ ++ +L+ E+R +L A L+QF DA+D E W+ + + S VG D
Sbjct: 719 STRAAELQAQWERLEALAEERAQRLAQAASLYQFQADANDMEAWLVDALRLVSSPEVGHD 778
Query: 361 LIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANRDIEKKIDDMKNLWSDL 540
Q L ++H+A++ E+ H P L+ E + +++ ++ ++ + +L
Sbjct: 779 EFSTQALARQHRALEEEIRAHRPT-LDALREQAAALPPALSHTPEVQGRVPTLEQHYEEL 837
Query: 541 KNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFGKDEDSTEALLKKHDAL 720
+ +A +R + L+ +L L++A W+ EKE + + + E + ++ + L
Sbjct: 838 QARAGERARALEAALAFYTMLSEAGACGLWVEEKEQWLNGLALPERLEDLEVVQQRFETL 897
Query: 721 MADIEAYRSTIDSLRTQADACKMQEAPVSD 810
++ A + + ++ A+ P D
Sbjct: 898 EPEMNALAARVTAVSDIAEQLLKASPPGKD 927
Score = 101 bits (251), Expect = 3e-21
Identities = 63/248 (25%), Positives = 125/248 (50%), Gaps = 4/248 (1%)
Frame = +1
Query: 1 EVESQLGSDDCGKDLNSVTNLQKKHNLLESDISSHQDRIDSFLQQADQFVHDNHFDADAI 180
E + + D+ G +L +V +KH +E+DI ++ R+ + A + +++ D I
Sbjct: 443 ENQRLVSQDNFGLELAAVEAAVRKHEAIETDIVAYSGRVQAVDAVAAELAAEHYHDIKRI 502
Query: 181 KKKQIEVCNRYSKLQEPLEKRKNKLNDAYKLHQFYRDADDEEDWIHEKEPIAGSTNVGRD 360
+Q V + L+E + R+ +L +L + ++D DW+ E + S ++G+
Sbjct: 503 AARQNNVARLWDFLREMVAARRERLLLNLELQKVFQDLLYLMDWMAEMKGRLQSQDLGKH 562
Query: 361 LIGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMID-GNHYANRD---IEKKIDDMKNL 528
L GV++L++ H+ ++A++ R+ V + D G Y D + +++ ++
Sbjct: 563 LAGVEDLLQLHELVEADIAVQAERVRAVSASALRFCDPGKEYRPCDPQLVSERVATLEQS 622
Query: 529 WSDLKNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFGKDEDSTEALLKK 708
+ L A RR L++S ++L + EAE+W+RE++ L+ S E G+D LL K
Sbjct: 623 YEALCELAATRRARLEESRRLWRFLWEVGEAEAWVREQQHLLASAETGRDLTGVLRLLNK 682
Query: 709 HDALMADI 732
H AL ++
Sbjct: 683 HTALRGEM 690
Score = 100 bits (249), Expect = 5e-21
Identities = 71/271 (26%), Positives = 127/271 (46%), Gaps = 1/271 (0%)
Frame = +1
Query: 1 EVESQLGSDDCGKDLNSVTNLQKKHNLLESDISSHQDRIDSFLQQADQFVHDNHFDADAI 180
E E + + KD S KKH +LE ++ + I + + H ++ +
Sbjct: 1606 EQELHMMGQEKAKDELSAQAEVKKHQVLEQALADYAQTIKQLAASSQDMIDHEHPESTRL 1665
Query: 181 KKKQIEVCNRYSKLQEPLEKRKNKLNDAYKLHQFYRDADDEEDWIHEKEPIAGSTNVGRD 360
+Q +V Y+ L+E +R+ +L + +L Q R+ DD E WI E+E +A S +G+D
Sbjct: 1666 TIRQAQVDKLYAGLKELAGERRERLQEHLRLCQLRRELDDLEQWIQEREVVAASHELGQD 1725
Query: 361 LIGVQNLIKKHQAIQAEV-TGHEPRILEVCNEGQKMIDGNHYANRDIEKKIDDMKNLWSD 537
V L K + + T + R+ +I G H A + + D + W+D
Sbjct: 1726 YEHVTMLRDKFREFSRDTSTIGQERVDSANALANGLIAGGHAARATVAEWKDSLNEAWAD 1785
Query: 538 LKNKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFGKDEDSTEALLKKHDA 717
L D R Q+L + E Q++L A +A + ++ K+ + G+D ++ EAL ++H A
Sbjct: 1786 LLELLDTRGQVLAAAYELQRFLHGARQALARVQHKQQQLPDGT-GRDLNAAEALQRRHCA 1844
Query: 718 LMADIEAYRSTIDSLRTQADACKMQEAPVSD 810
DI+A + + + Q D ++Q+A D
Sbjct: 1845 YEHDIQALSTQVQ--QVQDDGLRLQKAYAGD 1873
Score = 96.3 bits (238), Expect = 1e-19
Identities = 65/250 (26%), Positives = 113/250 (45%), Gaps = 4/250 (1%)
Frame = +1
Query: 25 DDCGKDLNSVTNLQKKHNLLESDISSHQDRI----DSFLQQADQFVHDNHFDADAIKKKQ 192
D G+DLN+ LQ++H E DI + ++ D L+ + D A+ I +
Sbjct: 1826 DGTGRDLNAAEALQRRHCAYEHDIQALSTQVQQVQDDGLRLQKAYAGDK---AEEIGRHM 1882
Query: 193 IEVCNRYSKLQEPLEKRKNKLNDAYKLHQFYRDADDEEDWIHEKEPIAGSTNVGRDLIGV 372
V +++LQ R+ L D +F++ + W+ + RD+
Sbjct: 1883 QAVAEAWAQLQGSSAARRQLLLDTTDKFRFFKAVRELMLWMDGINLQMDAQERPRDVSSA 1942
Query: 373 QNLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANRDIEKKIDDMKNLWSDLKNKA 552
+IK Q I+AE+ R + GQ+++ NHYA +I +K+ +++ + K
Sbjct: 1943 DLVIKNQQGIKAEIEARADRFSACIDMGQELLARNHYAAEEISEKLSQLQSRRQETAEKW 2002
Query: 553 DKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFGKDEDSTEALLKKHDALMADI 732
++ L LE + DA AE+W+ +EPLV S E G D E+L+K+H+A
Sbjct: 2003 QEKMDWLQLVLEVLVFGRDAGMAEAWLCSQEPLVRSAELGCTVDEVESLIKRHEAFQKSA 2062
Query: 733 EAYRSTIDSL 762
A+ +L
Sbjct: 2063 VAWEERFSAL 2072
Score = 90.5 bits (223), Expect = 5e-18
Identities = 57/243 (23%), Positives = 114/243 (46%)
Frame = +1
Query: 67 KKHNLLESDISSHQDRIDSFLQQADQFVHDNHFDADAIKKKQIEVCNRYSKLQEPLEKRK 246
KK S + ++ +RI L+ Q V + A+ I++K + R+ K QE +++
Sbjct: 1212 KKLEDFMSTMDANGERIRGLLEAGRQLVSKGNIHAEKIQEKADSIEKRHRKNQEAVQQLL 1271
Query: 247 NKLNDAYKLHQFYRDADDEEDWIHEKEPIAGSTNVGRDLIGVQNLIKKHQAIQAEVTGHE 426
+L D + F +D + + WI EK A + + + +KHQA AE+ ++
Sbjct: 1272 GRLRDNREQQHFLQDCQELKLWIDEKMLTAQDVSYD-EARNLHTKWQKHQAFMAELAANK 1330
Query: 427 PRILEVCNEGQKMIDGNHYANRDIEKKIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYLA 606
+ +V EG+++ + +K++D+ W +L+ + + L D+ A+ +
Sbjct: 1331 DWLDKVDKEGRELTLEKPELKVLVSEKLEDLHRRWDELETTTQAKARSLFDANRAELFAQ 1390
Query: 607 DASEAESWMREKEPLVGSTEFGKDEDSTEALLKKHDALMADIEAYRSTIDSLRTQADACK 786
S ESW+ + + S ++GKD S LLKK L ++ +++++ QA A
Sbjct: 1391 SCSALESWLESLQAQLHSDDYGKDLTSVNILLKKQQMLEREMAVREKEVEAIQAQAKALA 1450
Query: 787 MQE 795
++
Sbjct: 1451 QED 1453
Score = 85.5 bits (210), Expect = 2e-16
Identities = 57/267 (21%), Positives = 121/267 (45%), Gaps = 1/267 (0%)
Frame = +1
Query: 43 LNSVTNLQKKHNLLESDISSHQDRIDSFLQQADQFVHDNHFDADAIKKKQIEVCNRYSKL 222
L + +Q++ LE ++++ R+ + A+Q + + D I Q ++ R+ +
Sbjct: 884 LEDLEVVQQRFETLEPEMNALAARVTAVSDIAEQLLKASPPGKDRIIGTQEQLNQRWQQF 943
Query: 223 QEPLEKRKNKLNDAYKLHQFYRDADDEEDWIHEKEPIAGST-NVGRDLIGVQNLIKKHQA 399
+ + +K L A + ++ + + + W+ EK + ST ++G DL GV L +K
Sbjct: 944 RSLADGKKAALTSALSIQNYHLECTETQAWMREKTKVIESTQDLGNDLAGVLALQRKLAG 1003
Query: 400 IQAEVTGHEPRILEVCNEGQKMIDGNHYANRDIEKKIDDMKNLWSDLKNKADKRRQLLDD 579
+ ++ R+ E+ E + G+ I ++ +++ W DL+ +R + L +
Sbjct: 1004 TERDLEAISARVGELTQEANALAAGHPAQAPAINTRLGEVQTGWEDLRATMRRREESLGE 1063
Query: 580 SLEAQQYLADASEAESWMREKEPLVGSTEFGKDEDSTEALLKKHDALMADIEAYRSTIDS 759
+ Q +L + ++W+ + V S E EALL +H AL ++E +S
Sbjct: 1064 ARRLQDFLRSLDDFQAWLGRTQTAVASEEGPATLPEAEALLAQHAALRGEVERAQSEYSR 1123
Query: 760 LRTQADACKMQEAPVSDSYGKETVMAL 840
LRT + +A + ++ + AL
Sbjct: 1124 LRTLGEEVTRDQADPQCLFLRQRLEAL 1150
Score = 76.3 bits (186), Expect = 1e-13
Identities = 55/256 (21%), Positives = 112/256 (43%), Gaps = 1/256 (0%)
Frame = +1
Query: 16 LGSDDCGKDLNSVTNLQKKHNLLESDISSHQDRIDSFLQQADQFVHDNHFDADAIKKKQI 195
+ S + G D S L ++H LE +I +H+ +D+ +QA + ++ +
Sbjct: 770 VSSPEVGHDEFSTQALARQHRALEEEIRAHRPTLDALREQAAALPPALSHTPE-VQGRVP 828
Query: 196 EVCNRYSKLQEPLEKRKNKLNDAYKLHQFYRDADDEEDWIHEKEPIAGSTNVGRDLIGVQ 375
+ Y +LQ +R L A + +A W+ EKE + L ++
Sbjct: 829 TLEQHYEELQARAGERARALEAALAFYTMLSEAGACGLWVEEKEQWLNGLALPERLEDLE 888
Query: 376 NLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANRDIEKKIDDMKNLWSDLKNKAD 555
+ ++ + ++ E+ R+ V + ++++ + I + + W ++ AD
Sbjct: 889 VVQQRFETLEPEMNALAARVTAVSDIAEQLLKASPPGKDRIIGTQEQLNQRWQQFRSLAD 948
Query: 556 KRRQLLDDSLEAQQYLADASEAESWMREKEPLVGST-EFGKDEDSTEALLKKHDALMADI 732
++ L +L Q Y + +E ++WMREK ++ ST + G D AL +K D+
Sbjct: 949 GKKAALTSALSIQNYHLECTETQAWMREKTKVIESTQDLGNDLAGVLALQRKLAGTERDL 1008
Query: 733 EAYRSTIDSLRTQADA 780
EA + + L +A+A
Sbjct: 1009 EAISARVGELTQEANA 1024
Score = 75.5 bits (184), Expect = 2e-13
Identities = 57/248 (22%), Positives = 108/248 (43%), Gaps = 1/248 (0%)
Frame = +1
Query: 22 SDDCGKDLNSVTNLQKKHNLLESDISSHQDRIDSFLQQADQFVHDNHFDADAIKKKQIEV 201
+ D G DL V LQ+K E D+ + R+ Q+A+ + A AI + EV
Sbjct: 984 TQDLGNDLAGVLALQRKLAGTERDLEAISARVGELTQEANALAAGHPAQAPAINTRLGEV 1043
Query: 202 CNRYSKLQEPLEKRKNKLNDAYKLHQFYRDADDEEDWIHEKEPIAGSTNVGRDLIGVQNL 381
+ L+ + +R+ L +A +L F R DD + W+ + S L + L
Sbjct: 1044 QTGWEDLRATMRRREESLGEARRLQDFLRSLDDFQAWLGRTQTAVASEEGPATLPEAEAL 1103
Query: 382 IKKHQAIQAEVTGHEPRILEVCNEGQKMI-DGNHYANRDIEKKIDDMKNLWSDLKNKADK 558
+ +H A++ EV + + G+++ D + ++++ + W +L +
Sbjct: 1104 LAQHAALRGEVERAQSEYSRLRTLGEEVTRDQADPQCLFLRQRLEALGTGWEELGRMWES 1163
Query: 559 RRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFGKDEDSTEALLKKHDALMADIEA 738
R+ L + Q +L DA +AE + +E + TE + +A +KK + M+ ++A
Sbjct: 1164 RQGRLAQAHGFQGFLRDARQAEGVLSSQEYFLSHTEMPGTLQAADAAIKKLEDFMSTMDA 1223
Query: 739 YRSTIDSL 762
I L
Sbjct: 1224 NGERIRGL 1231
Score = 71.2 bits (173), Expect = 3e-12
Identities = 41/166 (24%), Positives = 78/166 (46%)
Frame = +1
Query: 277 QFYRDADDEEDWIHEKEPIAGSTNVGRDLIGVQNLIKKHQAIQAEVTGHEPRILEVCNEG 456
+F R A E W+ E + + N G +L V+ ++KH+AI+ ++ + R+ V
Sbjct: 429 RFDRKAAMRETWLSENQRLVSQDNFGLELAAVEAAVRKHEAIETDIVAYSGRVQAVDAVA 488
Query: 457 QKMIDGNHYANRDIEKKIDDMKNLWSDLKNKADKRRQLLDDSLEAQQYLADASEAESWMR 636
++ +++ + I + +++ LW L+ RR+ L +LE Q+ D WM
Sbjct: 489 AELAAEHYHDIKRIAARQNNVARLWDFLREMVAARRERLLLNLELQKVFQDLLYLMDWMA 548
Query: 637 EKEPLVGSTEFGKDEDSTEALLKKHDALMADIEAYRSTIDSLRTQA 774
E + + S + GK E LL+ H+ + ADI + ++ A
Sbjct: 549 EMKGRLQSQDLGKHLAGVEDLLQLHELVEADIAVQAERVRAVSASA 594
Score = 63.5 bits (153), Expect = 7e-10
Identities = 34/143 (23%), Positives = 73/143 (51%)
Frame = +1
Query: 4 VESQLGSDDCGKDLNSVTNLQKKHNLLESDISSHQDRIDSFLQQADQFVHDNHFDADAIK 183
+ Q+ + + +D++S + K ++++I + DR + + + + NH+ A+ I
Sbjct: 1926 INLQMDAQERPRDVSSADLVIKNQQGIKAEIEARADRFSACIDMGQELLARNHYAAEEIS 1985
Query: 184 KKQIEVCNRYSKLQEPLEKRKNKLNDAYKLHQFYRDADDEEDWIHEKEPIAGSTNVGRDL 363
+K ++ +R + E +++ + L ++ F RDA E W+ +EP+ S +G +
Sbjct: 1986 EKLSQLQSRRQETAEKWQEKMDWLQLVLEVLVFGRDAGMAEAWLCSQEPLVRSAELGCTV 2045
Query: 364 IGVQNLIKKHQAIQAEVTGHEPR 432
V++LIK+H+A Q E R
Sbjct: 2046 DEVESLIKRHEAFQKSAVAWEER 2068
Score = 57.8 bits (138), Expect = 4e-08
Identities = 49/254 (19%), Positives = 102/254 (40%), Gaps = 2/254 (0%)
Frame = +1
Query: 7 ESQLGSDDCGKDLNSVTNLQKKHNLLESDISSHQDRIDSFLQQADQFVHDNHFDADAIKK 186
++ + S++ L L +H L ++ Q ++ D +
Sbjct: 1085 QTAVASEEGPATLPEAEALLAQHAALRGEVERAQSEYSRLRTLGEEVTRDQADPQCLFLR 1144
Query: 187 KQIEVCNR-YSKLQEPLEKRKNKLNDAYKLHQFYRDADDEEDWIHEKEPIAGSTNVGRDL 363
+++E + +L E R+ +L A+ F RDA E + +E T + L
Sbjct: 1145 QRLEALGTGWEELGRMWESRQGRLAQAHGFQGFLRDARQAEGVLSSQEYFLSHTEMPGTL 1204
Query: 364 IGVQNLIKKHQAIQAEVTGHEPRILEVCNEGQKMIDGNHYANRDIEKKIDDMKNLWSDLK 543
IKK + + + + RI + G++++ + I++K D ++ +
Sbjct: 1205 QAADAAIKKLEDFMSTMDANGERIRGLLEAGRQLVSKGNIHAEKIQEKADSIEKRHRKNQ 1264
Query: 544 NKADKRRQLLDDSLEAQQYLADASEAESWMREKEPLVGSTEFGKDE-DSTEALLKKHDAL 720
+ L D+ E Q +L D E + W+ EK ++ + + DE + +KH A
Sbjct: 1265 EAVQQLLGRLRDNREQQHFLQDCQELKLWIDEK--MLTAQDVSYDEARNLHTKWQKHQAF 1322
Query: 721 MADIEAYRSTIDSL 762
MA++ A + +D +
Sbjct: 1323 MAELAANKDWLDKV 1336
Score = 47.8 bits (112), Expect = 4e-05
Identities = 60/271 (22%), Positives = 105/271 (38%), Gaps = 29/271 (10%)
Frame = +1
Query: 37 KDLNSVTNLQKKHNLLESDISSHQ--DRIDSFLQQADQ----------FVHDNHFDADAI 180
K N+ NLQ NL E ++ + D D + Q D+ + + + A A+
Sbjct: 229 KKCNAHYNLQNAFNLAEKELGLTKLLDPEDVNVDQPDEKSIITYVATYYHYFSKMKALAV 288
Query: 181 KKKQIEVCNRYSKLQEPLEKRKNKLNDAYKLHQFYRDADDEEDWIHEKEPIAGSTNVGRD 360
+ K+I ++ E L ++ L A + WI + +
Sbjct: 289 EGKRIGKVLDHAMEAEHLVEKYESL------------ASELLQWIEQTIVTLNDRQLANS 336
Query: 361 LIGVQNLIKKHQAIQAEVTGHEPRILEVCNEG------QKMIDGNH---YANRDIEKKID 513
L GVQN ++ + + P+ E N Q + N+ Y R+ + I
Sbjct: 337 LSGVQNQLQSFNSYRT--VEKPPKFTEKGNLEVLLFTIQSKLRANNQKVYTpre-GRLIS 393
Query: 514 DMKNLWSDLKNKADKRRQLLDDSLEAQQYLAD--------ASEAESWMREKEPLVGSTEF 669
D+ W L+ +R L L Q+ L A+ E+W+ E + LV F
Sbjct: 394 DINKAWERLEKAEHERELALRTELIRQEKLEQLAARFDRKAAMRETWLSENQRLVSQDNF 453
Query: 670 GKDEDSTEALLKKHDALMADIEAYRSTIDSL 762
G + + EA ++KH+A+ DI AY + ++
Sbjct: 454 GLELAAVEAAVRKHEAIETDIVAYSGRVQAV 484
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.311 0.129 0.365
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 81,448,411
Number of Sequences: 369166
Number of extensions: 1488962
Number of successful extensions: 5347
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 4541
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 5114
length of database: 68,354,980
effective HSP length: 109
effective length of database: 48,218,865
effective search space used: 8390082510
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)