Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_025_O11
(644 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q95029|CATL_DROME Cathepsin L precursor (Cysteine protei... 192 6e-49
sp|Q26636|CATL_SARPE Cathepsin L precursor [Contains: Cathe... 190 2e-48
sp|Q24940|CATLP_FASHE Cathepsin L-like proteinase precursor 176 4e-44
sp|P25782|CYSP2_HOMAM Digestive cysteine proteinase 2 precu... 169 7e-42
sp|P07711|CATL_HUMAN Cathepsin L precursor (Major excreted ... 167 2e-41
sp|O60911|CATL2_HUMAN Cathepsin L2 precursor (Cathepsin V) ... 165 8e-41
sp|P06797|CATL_MOUSE Cathepsin L precursor (Major excreted ... 165 1e-40
sp|P25784|CYSP3_HOMAM Digestive cysteine proteinase 3 precu... 165 1e-40
sp|P07154|CATL_RAT Cathepsin L precursor (Major excreted pr... 164 1e-40
sp|Q9GL24|CATL_CANFA Cathepsin L precursor [Contains: Cathe... 164 2e-40
>sp|Q95029|CATL_DROME Cathepsin L precursor (Cysteine proteinase 1) [Contains: Cathepsin
L heavy chain; Cathepsin L light chain]
Length = 341
Score = 192 bits (488), Expect = 6e-49
Identities = 88/173 (50%), Positives = 122/173 (70%), Gaps = 2/173 (1%)
Frame = +1
Query: 1 MSFSEEQLIDCSDAYGNSGCKGGSPDNSFNYYKPYG-MNNEETYPYFGIKDRCKYNNNSV 177
+S SE+ L+DCS YGN+GC GG DN+F Y K G ++ E++YPY I D C +N +V
Sbjct: 169 VSLSEQNLVDCSTKYGNNGCNGGLMDNAFRYIKDNGGIDTEKSYPYEAIDDSCHFNKGTV 228
Query: 178 IAHVVSFIDVARNNEIQVAAAVSAEGPLTAIIDASLPSFQFYREGIYNDPTCSKTSPNHA 357
A F D+ + +E ++A AV+ GP++ IDAS SFQFY EG+YN+P C + +H
Sbjct: 229 GATDRGFTDIPQGDEKKMAEAVATVGPVSVAIDASHESFQFYSEGVYNEPQCDAQNLDHG 288
Query: 358 VLIVGYGESE-GEDYWIVKNSWGAMWGDHGYIKMIRDGNNQCGIASSTSFPIL 513
VL+VG+G E GEDYW+VKNSWG WGD G+IKM+R+ NQCGIAS++S+P++
Sbjct: 289 VLVVGFGTDESGEDYWLVKNSWGTTWGDKGFIKMLRNKENQCGIASASSYPLV 341
>sp|Q26636|CATL_SARPE Cathepsin L precursor [Contains: Cathepsin L heavy chain; Cathepsin
L light chain]
Length = 339
Score = 190 bits (483), Expect = 2e-48
Identities = 86/171 (50%), Positives = 119/171 (69%), Gaps = 2/171 (1%)
Frame = +1
Query: 1 MSFSEEQLIDCSDAYGNSGCKGGSPDNSFNYYKPYG-MNNEETYPYFGIKDRCKYNNNSV 177
+S SE+ L+DCS YGN+GC GG DN+F Y K G ++ E++YPY GI D C +N ++
Sbjct: 167 VSLSEQNLVDCSTKYGNNGCNGGLMDNAFRYIKDNGGIDTEKSYPYEGIDDSCHFNKATI 226
Query: 178 IAHVVSFIDVARNNEIQVAAAVSAEGPLTAIIDASLPSFQFYREGIYNDPTCSKTSPNHA 357
A F+D+ +E ++ AV+ GP++ IDAS SFQ Y EG+YN+P C + + +H
Sbjct: 227 GATDTGFVDIPEGDEEKMKKAVATMGPVSVAIDASHESFQLYSEGVYNEPECDEQNLDHG 286
Query: 358 VLIVGYGESE-GEDYWIVKNSWGAMWGDHGYIKMIRDGNNQCGIASSTSFP 507
VL+VGYG E G DYW+VKNSWG WG+ GYIKM R+ NNQCGIA+++S+P
Sbjct: 287 VLVVGYGTDESGMDYWLVKNSWGTTWGEQGYIKMARNQNNQCGIATASSYP 337
>sp|Q24940|CATLP_FASHE Cathepsin L-like proteinase precursor
Length = 326
Score = 176 bits (447), Expect = 4e-44
Identities = 78/171 (45%), Positives = 105/171 (61%)
Frame = +1
Query: 1 MSFSEEQLIDCSDAYGNSGCKGGSPDNSFNYYKPYGMNNEETYPYFGIKDRCKYNNNSVI 180
+SFSE+QL+DCS +GN+GC GG +N++ Y K +G+ E +YPY ++ +C+YN +
Sbjct: 153 ISFSEQQLVDCSGPWGNNGCSGGLMENAYQYLKQFGLETESSYPYTAVEGQCRYNKQLGV 212
Query: 181 AHVVSFIDVARNNEIQVAAAVSAEGPLTAIIDASLPSFQFYREGIYNDPTCSKTSPNHAV 360
A V + V +E+++ V A P +D F YR GIY TCS NHAV
Sbjct: 213 AKVTGYYTVHSGSEVELKNLVGARRPAAVAVDVE-SDFMMYRSGIYQSQTCSPLRVNHAV 271
Query: 361 LIVGYGESEGEDYWIVKNSWGAMWGDHGYIKMIRDGNNQCGIASSTSFPIL 513
L VGYG G DYWIVKNSWG WG+ GYI+M R+ N CGIAS S P++
Sbjct: 272 LAVGYGTQGGTDYWIVKNSWGTYWGERGYIRMARNRGNMCGIASLASLPMV 322
>sp|P25782|CYSP2_HOMAM Digestive cysteine proteinase 2 precursor
Length = 323
Score = 169 bits (427), Expect = 7e-42
Identities = 78/172 (45%), Positives = 112/172 (65%), Gaps = 1/172 (0%)
Frame = +1
Query: 1 MSFSEEQLIDCSDAYGNSGCKGGSPDNSFNYYKPY-GMNNEETYPYFGIKDRCKYNNNSV 177
+S +E+QL+DCS YG GC GG +++F+Y K G++ E YPY C++++NSV
Sbjct: 152 ISLAEQQLVDCSRPYGPQGCNGGWMNDAFDYIKANNGIDTEAAYPYEARDGSCRFDSNSV 211
Query: 178 IAHVVSFIDVARNNEIQVAAAVSAEGPLTAIIDASLPSFQFYREGIYNDPTCSKTSPNHA 357
A ++A +E + AV GP++ IDA+ SFQFY G+Y +P+CS + +HA
Sbjct: 212 AATCSGHTNIASGSETGLQQAVRDIGPISVTIDAAHSSFQFYSSGVYYEPSCSPSYLDHA 271
Query: 358 VLIVGYGESEGEDYWIVKNSWGAMWGDHGYIKMIRDGNNQCGIASSTSFPIL 513
VL VGYG G+D+W+VKNSW WGD GYIKM R+ NN CGIA+ S+P++
Sbjct: 272 VLAVGYGSEGGQDFWLVKNSWATSWGDAGYIKMSRNRNNNCGIATVASYPLV 323
>sp|P07711|CATL_HUMAN Cathepsin L precursor (Major excreted protein) (MEP) [Contains:
Cathepsin L heavy chain; Cathepsin L light chain]
Length = 333
Score = 167 bits (424), Expect = 2e-41
Identities = 80/174 (45%), Positives = 110/174 (63%), Gaps = 5/174 (2%)
Frame = +1
Query: 1 MSFSEEQLIDCSDAYGNSGCKGGSPDNSFNYYKPYG-MNNEETYPYFGIKDRCKYNNNSV 177
+S SE+ L+DCS GN GC GG D +F Y + G +++EE+YPY ++ CKYN
Sbjct: 159 ISLSEQNLVDCSGPQGNEGCNGGLMDYAFQYVQDNGGLDSEESYPYEATEESCKYNPKYS 218
Query: 178 IAHVVSFIDVARNNEIQVAAAVSAEGPLTAIIDASLPSFQFYREGIYNDPTCSKTSPNHA 357
+A+ F+D+ + E + AV+ GP++ IDA SF FY+EGIY +P CS +H
Sbjct: 219 VANDTGFVDIPKQ-EKALMKAVATVGPISVAIDAGHESFLFYKEGIYFEPDCSSEDMDHG 277
Query: 358 VLIVGYG----ESEGEDYWIVKNSWGAMWGDHGYIKMIRDGNNQCGIASSTSFP 507
VL+VGYG ES+ YW+VKNSWG WG GY+KM +D N CGIAS+ S+P
Sbjct: 278 VLVVGYGFESTESDNNKYWLVKNSWGEEWGMGGYVKMAKDRRNHCGIASAASYP 331
>sp|O60911|CATL2_HUMAN Cathepsin L2 precursor (Cathepsin V) (Cathepsin U)
Length = 334
Score = 165 bits (418), Expect = 8e-41
Identities = 77/174 (44%), Positives = 108/174 (62%), Gaps = 5/174 (2%)
Frame = +1
Query: 1 MSFSEEQLIDCSDAYGNSGCKGGSPDNSFNYYKPYG-MNNEETYPYFGIKDRCKYNNNSV 177
+S SE+ L+DCS GN GC GG +F Y K G +++EE+YPY + + CKY +
Sbjct: 159 VSLSEQNLVDCSRPQGNQGCNGGFMARAFQYVKENGGLDSEESYPYVAVDEICKYRPENS 218
Query: 178 IAHVVSFIDVARNNEIQVAAAVSAEGPLTAIIDASLPSFQFYREGIYNDPTCSKTSPNHA 357
+A+ F VA E + AV+ GP++ +DA SFQFY+ GIY +P CS + +H
Sbjct: 219 VANDTGFTVVAPGKEKALMKAVATVGPISVAMDAGHSSFQFYKSGIYFEPDCSSKNLDHG 278
Query: 358 VLIVGYG----ESEGEDYWIVKNSWGAMWGDHGYIKMIRDGNNQCGIASSTSFP 507
VL+VGYG S YW+VKNSWG WG +GY+K+ +D NN CGIA++ S+P
Sbjct: 279 VLVVGYGFEGANSNNSKYWLVKNSWGPEWGSNGYVKIAKDKNNHCGIATAASYP 332
>sp|P06797|CATL_MOUSE Cathepsin L precursor (Major excreted protein) (MEP) (p39 cysteine
proteinase) [Contains: Cathepsin L heavy chain;
Cathepsin L light chain]
Length = 334
Score = 165 bits (417), Expect = 1e-40
Identities = 78/176 (44%), Positives = 112/176 (63%), Gaps = 5/176 (2%)
Frame = +1
Query: 1 MSFSEEQLIDCSDAYGNSGCKGGSPDNSFNYYKPYG-MNNEETYPYFGIKDRCKYNNNSV 177
+S SE+ L+DCS A GN GC GG D +F Y K G +++EE+YPY CKY
Sbjct: 159 ISLSEQNLVDCSHAQGNQGCNGGLMDFAFQYIKENGGLDSEESYPYEAKDGSCKYRAEFA 218
Query: 178 IAHVVSFIDVARNNEIQVAAAVSAEGPLTAIIDASLPSFQFYREGIYNDPTCSKTSPNHA 357
+A+ F+D+ + E + AV+ GP++ +DAS PS QFY GIY +P CS + +H
Sbjct: 219 VANDTGFVDIPQQ-EKALMKAVATVGPISVAMDASHPSLQFYSSGIYYEPNCSSKNLDHG 277
Query: 358 VLIVGYG----ESEGEDYWIVKNSWGAMWGDHGYIKMIRDGNNQCGIASSTSFPIL 513
VL+VGYG +S YW+VKNSWG+ WG GYIK+ +D +N CG+A++ S+P++
Sbjct: 278 VLLVGYGYEGTDSNKNKYWLVKNSWGSEWGMEGYIKIAKDRDNHCGLATAASYPVV 333
>sp|P25784|CYSP3_HOMAM Digestive cysteine proteinase 3 precursor
Length = 321
Score = 165 bits (417), Expect = 1e-40
Identities = 81/170 (47%), Positives = 108/170 (63%), Gaps = 1/170 (0%)
Frame = +1
Query: 1 MSFSEEQLIDCSDAYGNSGCKGGSPDNSFNYYKPYG-MNNEETYPYFGIKDRCKYNNNSV 177
+S SE+QL+DCS YGN GC GG ++F+Y K G ++ E +YPY C+++ NS+
Sbjct: 151 VSLSEQQLVDCSTDYGNDGCGGGWMTSAFDYIKDNGGIDTESSYPYEAEDRSCRFDANSI 210
Query: 178 IAHVVSFIDVARNNEIQVAAAVSAEGPLTAIIDASLPSFQFYREGIYNDPTCSKTSPNHA 357
A ++V E + AVS GP++ IDAS SFQFY G+Y + CS T +H
Sbjct: 211 GAICTGSVEVQHTEEA-LQEAVSGVGPISVAIDASHFSFQFYSSGVYYEQNCSPTFLDHG 269
Query: 358 VLIVGYGESEGEDYWIVKNSWGAMWGDHGYIKMIRDGNNQCGIASSTSFP 507
VL VGYG +DYW+VKNSWG+ WGD GYIKM R+ +N CGIAS S+P
Sbjct: 270 VLAVGYGTESTKDYWLVKNSWGSSWGDAGYIKMSRNRDNNCGIASEPSYP 319
>sp|P07154|CATL_RAT Cathepsin L precursor (Major excreted protein) (MEP) (Cyclic
protein 2) (CP-2) [Contains: Cathepsin L heavy chain;
Cathepsin L light chain]
Length = 334
Score = 164 bits (416), Expect = 1e-40
Identities = 79/176 (44%), Positives = 110/176 (62%), Gaps = 5/176 (2%)
Frame = +1
Query: 1 MSFSEEQLIDCSDAYGNSGCKGGSPDNSFNYYKPYG-MNNEETYPYFGIKDRCKYNNNSV 177
+S SE+ L+DCS GN GC GG D +F Y K G +++EE+YPY CKY
Sbjct: 159 ISLSEQNLVDCSHDQGNQGCNGGLMDFAFQYIKENGGLDSEESYPYEAKDGSCKYRAEYA 218
Query: 178 IAHVVSFIDVARNNEIQVAAAVSAEGPLTAIIDASLPSFQFYREGIYNDPTCSKTSPNHA 357
+A+ F+D+ + E + AV+ GP++ +DAS PS QFY GIY +P CS +H
Sbjct: 219 VANDTGFVDIPQQ-EKALMKAVATVGPISVAMDASHPSLQFYSSGIYYEPNCSSKDLDHG 277
Query: 358 VLIVGYG----ESEGEDYWIVKNSWGAMWGDHGYIKMIRDGNNQCGIASSTSFPIL 513
VL+VGYG +S + YW+VKNSWG WG GYIK+ +D NN CG+A++ S+PI+
Sbjct: 278 VLVVGYGYEGTDSNKDKYWLVKNSWGKEWGMDGYIKIAKDRNNHCGLATAASYPIV 333
>sp|Q9GL24|CATL_CANFA Cathepsin L precursor [Contains: Cathepsin L heavy chain; Cathepsin
L light chain]
Length = 333
Score = 164 bits (415), Expect = 2e-40
Identities = 84/175 (48%), Positives = 111/175 (63%), Gaps = 6/175 (3%)
Frame = +1
Query: 1 MSFSEEQLIDCSDAYGNSGCKGGSPDNSFNYYKPYG-MNNEETYPYFGIK-DRCKYNNNS 174
+S SE+ L+DCS A GN GC GG DN+F Y K G +++EE+YPY G + C Y
Sbjct: 159 VSLSEQNLVDCSRAQGNEGCNGGLMDNAFRYVKDNGGLDSEESYPYLGRDTETCNYKPEC 218
Query: 175 VIAHVVSFIDVARNNEIQVAAAVSAEGPLTAIIDASLPSFQFYREGIYNDPTCSKTSPNH 354
A+ F+D+ + E + AV+ GP++ IDA SFQFY+ GIY DP CS +H
Sbjct: 219 SAANDTGFVDLPQR-EKALMKAVATLGPISVAIDAGHQSFQFYKSGIYFDPDCSSKDLDH 277
Query: 355 AVLIVGYGESEGED----YWIVKNSWGAMWGDHGYIKMIRDGNNQCGIASSTSFP 507
VL+VGYG EG D +WIVKNSWG WG +GY+KM +D NN CGIA++ S+P
Sbjct: 278 GVLVVGYG-FEGTDSNNKFWIVKNSWGPEWGWNGYVKMAKDQNNHCGIATAASYP 331
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 60,475,912
Number of Sequences: 369166
Number of extensions: 1076926
Number of successful extensions: 3491
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 3089
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 3176
length of database: 68,354,980
effective HSP length: 106
effective length of database: 48,773,070
effective search space used: 5267491560
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)