Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_025_O05
(661 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P25782|CYSP2_HOMAM Digestive cysteine proteinase 2 precu... 192 8e-49
sp|P06797|CATL_MOUSE Cathepsin L precursor (Major excreted ... 178 1e-44
sp|P25784|CYSP3_HOMAM Digestive cysteine proteinase 3 precu... 178 1e-44
sp|P07154|CATL_RAT Cathepsin L precursor (Major excreted pr... 178 1e-44
sp|P07711|CATL_HUMAN Cathepsin L precursor (Major excreted ... 174 2e-43
sp|O60911|CATL2_HUMAN Cathepsin L2 precursor (Cathepsin V) ... 174 2e-43
sp|Q9GLE3|CATK_PIG Cathepsin K precursor 172 5e-43
sp|P43235|CATK_HUMAN Cathepsin K precursor (Cathepsin O) (C... 172 7e-43
sp|P61277|CATK_MACMU Cathepsin K precursor >gi|47117667|sp|... 172 7e-43
sp|O35186|CATK_RAT Cathepsin K precursor 172 9e-43
>sp|P25782|CYSP2_HOMAM Digestive cysteine proteinase 2 precursor
Length = 323
Score = 192 bits (487), Expect = 8e-49
Identities = 91/158 (57%), Positives = 112/158 (70%), Gaps = 2/158 (1%)
Frame = +1
Query: 103 YKNSGCNGGWMNIAFEYI-SSHGIESEDNYPYQAKQGNCVFDKSKVVANCKGFQNINSCN 279
Y GCNGGWMN AF+YI +++GI++E YPY+A+ G+C FD + V A C G NI S +
Sbjct: 166 YGPQGCNGGWMNDAFDYIKANNGIDTEAAYPYEARDGSCRFDSNSVAATCSGHTNIASGS 225
Query: 280 EKDLAVAVATVGPISVAIDVGYS-FQQYKQGVYYEAKCDPTIQNHAVLVVGYGVENGHKY 456
E L AV +GPISV ID +S FQ Y GVYYE C P+ +HAVL VGYG E G +
Sbjct: 226 ETGLQQAVRDIGPISVTIDAAHSSFQFYSSGVYYEPSCSPSYLDHAVLAVGYGSEGGQDF 285
Query: 457 WLVKNSWGPSWGMNGYIKMSKDRDNNCGIATTASFPIV 570
WLVKNSW SWG GYIKMS++R+NNCGIAT AS+P+V
Sbjct: 286 WLVKNSWATSWGDAGYIKMSRNRNNNCGIATVASYPLV 323
Score = 55.5 bits (132), Expect = 1e-07
Identities = 25/33 (75%), Positives = 28/33 (84%)
Frame = +2
Query: 2 SCWAFSTTGSLEGQHFRKHKVLQNISEQQLVDC 100
SCWAFSTTGSLEGQHF K L +++EQQLVDC
Sbjct: 130 SCWAFSTTGSLEGQHFLKTGSLISLAEQQLVDC 162
>sp|P06797|CATL_MOUSE Cathepsin L precursor (Major excreted protein) (MEP) (p39 cysteine
proteinase) [Contains: Cathepsin L heavy chain;
Cathepsin L light chain]
Length = 334
Score = 178 bits (452), Expect = 1e-44
Identities = 89/160 (55%), Positives = 112/160 (70%), Gaps = 6/160 (3%)
Frame = +1
Query: 109 NSGCNGGWMNIAFEYISSHG-IESEDNYPYQAKQGNCVFDKSKVVANCKGFQNINSCNEK 285
N GCNGG M+ AF+YI +G ++SE++YPY+AK G+C + VAN GF +I EK
Sbjct: 175 NQGCNGGLMDFAFQYIKENGGLDSEESYPYEAKDGSCKYRAEFAVANDTGFVDIPQ-QEK 233
Query: 286 DLAVAVATVGPISVAIDVGY-SFQQYKQGVYYEAKCDPTIQNHAVLVVGYGVE----NGH 450
L AVATVGPISVA+D + S Q Y G+YYE C +H VL+VGYG E N +
Sbjct: 234 ALMKAVATVGPISVAMDASHPSLQFYSSGIYYEPNCSSKNLDHGVLLVGYGYEGTDSNKN 293
Query: 451 KYWLVKNSWGPSWGMNGYIKMSKDRDNNCGIATTASFPIV 570
KYWLVKNSWG WGM GYIK++KDRDN+CG+AT AS+P+V
Sbjct: 294 KYWLVKNSWGSEWGMEGYIKIAKDRDNHCGLATAASYPVV 333
Score = 45.4 bits (106), Expect = 1e-04
Identities = 21/33 (63%), Positives = 24/33 (72%)
Frame = +2
Query: 2 SCWAFSTTGSLEGQHFRKHKVLQNISEQQLVDC 100
SCWAFS +G LEGQ F K L ++SEQ LVDC
Sbjct: 137 SCWAFSASGCLEGQMFLKTGKLISLSEQNLVDC 169
>sp|P25784|CYSP3_HOMAM Digestive cysteine proteinase 3 precursor
Length = 321
Score = 178 bits (452), Expect = 1e-44
Identities = 87/158 (55%), Positives = 107/158 (67%), Gaps = 2/158 (1%)
Frame = +1
Query: 103 YKNSGCNGGWMNIAFEYISSHG-IESEDNYPYQAKQGNCVFDKSKVVANCKGFQNINSCN 279
Y N GC GGWM AF+YI +G I++E +YPY+A+ +C FD + + A C G +
Sbjct: 165 YGNDGCGGGWMTSAFDYIKDNGGIDTESSYPYEAEDRSCRFDANSIGAICTGSVEVQH-T 223
Query: 280 EKDLAVAVATVGPISVAIDVG-YSFQQYKQGVYYEAKCDPTIQNHAVLVVGYGVENGHKY 456
E+ L AV+ VGPISVAID +SFQ Y GVYYE C PT +H VL VGYG E+ Y
Sbjct: 224 EEALQEAVSGVGPISVAIDASHFSFQFYSSGVYYEQNCSPTFLDHGVLAVGYGTESTKDY 283
Query: 457 WLVKNSWGPSWGMNGYIKMSKDRDNNCGIATTASFPIV 570
WLVKNSWG SWG GYIKMS++RDNNCGIA+ S+P V
Sbjct: 284 WLVKNSWGSSWGDAGYIKMSRNRDNNCGIASEPSYPTV 321
Score = 56.6 bits (135), Expect = 6e-08
Identities = 25/35 (71%), Positives = 29/35 (82%)
Frame = +2
Query: 2 SCWAFSTTGSLEGQHFRKHKVLQNISEQQLVDCVT 106
SCWAFS TG+LEGQHF K+ L ++SEQQLVDC T
Sbjct: 129 SCWAFSATGALEGQHFLKNDELVSLSEQQLVDCST 163
>sp|P07154|CATL_RAT Cathepsin L precursor (Major excreted protein) (MEP) (Cyclic
protein 2) (CP-2) [Contains: Cathepsin L heavy chain;
Cathepsin L light chain]
Length = 334
Score = 178 bits (451), Expect = 1e-44
Identities = 90/160 (56%), Positives = 112/160 (70%), Gaps = 6/160 (3%)
Frame = +1
Query: 109 NSGCNGGWMNIAFEYISSHG-IESEDNYPYQAKQGNCVFDKSKVVANCKGFQNINSCNEK 285
N GCNGG M+ AF+YI +G ++SE++YPY+AK G+C + VAN GF +I EK
Sbjct: 175 NQGCNGGLMDFAFQYIKENGGLDSEESYPYEAKDGSCKYRAEYAVANDTGFVDIPQ-QEK 233
Query: 286 DLAVAVATVGPISVAIDVGY-SFQQYKQGVYYEAKCDPTIQNHAVLVVGYGVE----NGH 450
L AVATVGPISVA+D + S Q Y G+YYE C +H VLVVGYG E N
Sbjct: 234 ALMKAVATVGPISVAMDASHPSLQFYSSGIYYEPNCSSKDLDHGVLVVGYGYEGTDSNKD 293
Query: 451 KYWLVKNSWGPSWGMNGYIKMSKDRDNNCGIATTASFPIV 570
KYWLVKNSWG WGM+GYIK++KDR+N+CG+AT AS+PIV
Sbjct: 294 KYWLVKNSWGKEWGMDGYIKIAKDRNNHCGLATAASYPIV 333
Score = 45.4 bits (106), Expect = 1e-04
Identities = 21/33 (63%), Positives = 24/33 (72%)
Frame = +2
Query: 2 SCWAFSTTGSLEGQHFRKHKVLQNISEQQLVDC 100
SCWAFS +G LEGQ F K L ++SEQ LVDC
Sbjct: 137 SCWAFSASGCLEGQMFLKTGKLISLSEQNLVDC 169
>sp|P07711|CATL_HUMAN Cathepsin L precursor (Major excreted protein) (MEP) [Contains:
Cathepsin L heavy chain; Cathepsin L light chain]
Length = 333
Score = 174 bits (441), Expect = 2e-43
Identities = 87/160 (54%), Positives = 113/160 (70%), Gaps = 6/160 (3%)
Frame = +1
Query: 109 NSGCNGGWMNIAFEYISSHG-IESEDNYPYQAKQGNCVFDKSKVVANCKGFQNINSCNEK 285
N GCNGG M+ AF+Y+ +G ++SE++YPY+A + +C ++ VAN GF +I EK
Sbjct: 175 NEGCNGGLMDYAFQYVQDNGGLDSEESYPYEATEESCKYNPKYSVANDTGFVDIPK-QEK 233
Query: 286 DLAVAVATVGPISVAIDVGY-SFQQYKQGVYYEAKCDPTIQNHAVLVVGYGVEN----GH 450
L AVATVGPISVAID G+ SF YK+G+Y+E C +H VLVVGYG E+ +
Sbjct: 234 ALMKAVATVGPISVAIDAGHESFLFYKEGIYFEPDCSSEDMDHGVLVVGYGFESTESDNN 293
Query: 451 KYWLVKNSWGPSWGMNGYIKMSKDRDNNCGIATTASFPIV 570
KYWLVKNSWG WGM GY+KM+KDR N+CGIA+ AS+P V
Sbjct: 294 KYWLVKNSWGEEWGMGGYVKMAKDRRNHCGIASAASYPTV 333
Score = 50.1 bits (118), Expect = 5e-06
Identities = 23/33 (69%), Positives = 26/33 (78%)
Frame = +2
Query: 2 SCWAFSTTGSLEGQHFRKHKVLQNISEQQLVDC 100
SCWAFS TG+LEGQ FRK L ++SEQ LVDC
Sbjct: 137 SCWAFSATGALEGQMFRKTGRLISLSEQNLVDC 169
>sp|O60911|CATL2_HUMAN Cathepsin L2 precursor (Cathepsin V) (Cathepsin U)
Length = 334
Score = 174 bits (440), Expect = 2e-43
Identities = 87/160 (54%), Positives = 109/160 (68%), Gaps = 6/160 (3%)
Frame = +1
Query: 109 NSGCNGGWMNIAFEYISSHG-IESEDNYPYQAKQGNCVFDKSKVVANCKGFQNINSCNEK 285
N GCNGG+M AF+Y+ +G ++SE++YPY A C + VAN GF + EK
Sbjct: 175 NQGCNGGFMARAFQYVKENGGLDSEESYPYVAVDEICKYRPENSVANDTGFTVVAPGKEK 234
Query: 286 DLAVAVATVGPISVAIDVGYS-FQQYKQGVYYEAKCDPTIQNHAVLVVGYGVE----NGH 450
L AVATVGPISVA+D G+S FQ YK G+Y+E C +H VLVVGYG E N
Sbjct: 235 ALMKAVATVGPISVAMDAGHSSFQFYKSGIYFEPDCSSKNLDHGVLVVGYGFEGANSNNS 294
Query: 451 KYWLVKNSWGPSWGMNGYIKMSKDRDNNCGIATTASFPIV 570
KYWLVKNSWGP WG NGY+K++KD++N+CGIAT AS+P V
Sbjct: 295 KYWLVKNSWGPEWGSNGYVKIAKDKNNHCGIATAASYPNV 334
Score = 50.8 bits (120), Expect = 3e-06
Identities = 23/33 (69%), Positives = 26/33 (78%)
Frame = +2
Query: 2 SCWAFSTTGSLEGQHFRKHKVLQNISEQQLVDC 100
SCWAFS TG+LEGQ FRK L ++SEQ LVDC
Sbjct: 137 SCWAFSATGALEGQMFRKTGKLVSLSEQNLVDC 169
>sp|Q9GLE3|CATK_PIG Cathepsin K precursor
Length = 330
Score = 172 bits (437), Expect = 5e-43
Identities = 79/155 (50%), Positives = 108/155 (69%), Gaps = 2/155 (1%)
Frame = +1
Query: 106 KNSGCNGGWMNIAFEYISSH-GIESEDNYPYQAKQGNCVFDKSKVVANCKGFQNINSCNE 282
+N GC GG+M AF+Y+ + GI+SED YPY + NC+++ + A C+G++ I NE
Sbjct: 174 ENDGCGGGYMTNAFQYVQKNRGIDSEDAYPYVGQDENCMYNPTGKAAKCRGYREIPEGNE 233
Query: 283 KDLAVAVATVGPISVAIDVGY-SFQQYKQGVYYEAKCDPTIQNHAVLVVGYGVENGHKYW 459
K L AVA VGP+SVAID SFQ Y +GVYY+ C+ NHAVL VGYG++ G K+W
Sbjct: 234 KALKRAVARVGPVSVAIDASLTSFQFYSKGVYYDENCNSDNLNHAVLAVGYGIQKGKKHW 293
Query: 460 LVKNSWGPSWGMNGYIKMSKDRDNNCGIATTASFP 564
++KNSWG +WG GYI M+++++N CGIA ASFP
Sbjct: 294 IIKNSWGENWGNKGYILMARNKNNACGIANLASFP 328
Score = 46.2 bits (108), Expect = 8e-05
Identities = 21/36 (58%), Positives = 27/36 (75%)
Frame = +2
Query: 2 SCWAFSTTGSLEGQHFRKHKVLQNISEQQLVDCVTK 109
SCWAFS+ G+LEGQ +K L N+S Q LVDCV++
Sbjct: 139 SCWAFSSVGALEGQLKKKTGKLLNLSPQNLVDCVSE 174
>sp|P43235|CATK_HUMAN Cathepsin K precursor (Cathepsin O) (Cathepsin X) (Cathepsin O2)
Length = 329
Score = 172 bits (436), Expect = 7e-43
Identities = 78/155 (50%), Positives = 110/155 (70%), Gaps = 2/155 (1%)
Frame = +1
Query: 106 KNSGCNGGWMNIAFEYISSH-GIESEDNYPYQAKQGNCVFDKSKVVANCKGFQNINSCNE 282
+N GC GG+M AF+Y+ + GI+SED YPY ++ +C+++ + A C+G++ I NE
Sbjct: 173 ENDGCGGGYMTNAFQYVQKNRGIDSEDAYPYVGQEESCMYNPTGKAAKCRGYREIPEGNE 232
Query: 283 KDLAVAVATVGPISVAIDVGY-SFQQYKQGVYYEAKCDPTIQNHAVLVVGYGVENGHKYW 459
K L AVA VGP+SVAID SFQ Y +GVYY+ C+ NHAVL VGYG++ G+K+W
Sbjct: 233 KALKRAVARVGPVSVAIDASLTSFQFYSKGVYYDESCNSDNLNHAVLAVGYGIQKGNKHW 292
Query: 460 LVKNSWGPSWGMNGYIKMSKDRDNNCGIATTASFP 564
++KNSWG +WG GYI M+++++N CGIA ASFP
Sbjct: 293 IIKNSWGENWGNKGYILMARNKNNACGIANLASFP 327
Score = 46.2 bits (108), Expect = 8e-05
Identities = 21/36 (58%), Positives = 27/36 (75%)
Frame = +2
Query: 2 SCWAFSTTGSLEGQHFRKHKVLQNISEQQLVDCVTK 109
SCWAFS+ G+LEGQ +K L N+S Q LVDCV++
Sbjct: 138 SCWAFSSVGALEGQLKKKTGKLLNLSPQNLVDCVSE 173
>sp|P61277|CATK_MACMU Cathepsin K precursor
sp|P61276|CATK_MACFA Cathepsin K precursor
Length = 329
Score = 172 bits (436), Expect = 7e-43
Identities = 78/155 (50%), Positives = 110/155 (70%), Gaps = 2/155 (1%)
Frame = +1
Query: 106 KNSGCNGGWMNIAFEYISSH-GIESEDNYPYQAKQGNCVFDKSKVVANCKGFQNINSCNE 282
+N GC GG+M AF+Y+ + GI+SED YPY ++ +C+++ + A C+G++ I NE
Sbjct: 173 ENDGCGGGYMTNAFQYVQKNRGIDSEDAYPYVGQEESCMYNPTGKAAKCRGYREIPEGNE 232
Query: 283 KDLAVAVATVGPISVAIDVGY-SFQQYKQGVYYEAKCDPTIQNHAVLVVGYGVENGHKYW 459
K L AVA VGP+SVAID SFQ Y +GVYY+ C+ NHAVL VGYG++ G+K+W
Sbjct: 233 KALKRAVARVGPVSVAIDASLTSFQFYSKGVYYDESCNSDNLNHAVLAVGYGIQKGNKHW 292
Query: 460 LVKNSWGPSWGMNGYIKMSKDRDNNCGIATTASFP 564
++KNSWG +WG GYI M+++++N CGIA ASFP
Sbjct: 293 IIKNSWGENWGNKGYILMARNKNNACGIANLASFP 327
Score = 46.2 bits (108), Expect = 8e-05
Identities = 21/36 (58%), Positives = 27/36 (75%)
Frame = +2
Query: 2 SCWAFSTTGSLEGQHFRKHKVLQNISEQQLVDCVTK 109
SCWAFS+ G+LEGQ +K L N+S Q LVDCV++
Sbjct: 138 SCWAFSSVGALEGQLKKKTGKLLNLSPQNLVDCVSE 173
>sp|O35186|CATK_RAT Cathepsin K precursor
Length = 329
Score = 172 bits (435), Expect = 9e-43
Identities = 78/155 (50%), Positives = 108/155 (69%), Gaps = 2/155 (1%)
Frame = +1
Query: 106 KNSGCNGGWMNIAFEYISSHG-IESEDNYPYQAKQGNCVFDKSKVVANCKGFQNINSCNE 282
+N GC GG+M AF+Y+ +G I+SED YPY + +C+++ + A C+G++ I NE
Sbjct: 173 ENYGCGGGYMTTAFQYVQQNGGIDSEDAYPYVGQDESCMYNATAKAAKCRGYREIPVGNE 232
Query: 283 KDLAVAVATVGPISVAIDVGY-SFQQYKQGVYYEAKCDPTIQNHAVLVVGYGVENGHKYW 459
K L AVA VGP+SV+ID SFQ Y +GVYY+ CD NHAVLVVGYG + G+KYW
Sbjct: 233 KALKRAVARVGPVSVSIDASLTSFQFYSRGVYYDENCDRDNVNHAVLVVGYGTQKGNKYW 292
Query: 460 LVKNSWGPSWGMNGYIKMSKDRDNNCGIATTASFP 564
++KNSWG SWG GY+ ++++++N CGI ASFP
Sbjct: 293 IIKNSWGESWGNKGYVLLARNKNNACGITNLASFP 327
Score = 43.1 bits (100), Expect = 6e-04
Identities = 20/36 (55%), Positives = 26/36 (72%)
Frame = +2
Query: 2 SCWAFSTTGSLEGQHFRKHKVLQNISEQQLVDCVTK 109
SCWAFS+ G+LEGQ +K L +S Q LVDCV++
Sbjct: 138 SCWAFSSAGALEGQLKKKTGKLLALSPQNLVDCVSE 173
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 79,413,842
Number of Sequences: 369166
Number of extensions: 1653056
Number of successful extensions: 4526
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 3810
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 4114
length of database: 68,354,980
effective HSP length: 106
effective length of database: 48,773,070
effective search space used: 5511356910
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)