Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_025_M24
(898 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q9DGM7|MVP_ICTPU Major vault protein (MVP) 423 e-118
sp|P34118|MVPA_DICDI Major vault protein alpha (MVP-alpha) 412 e-115
sp|Q90405|MVP_DISOM Major vault protein (MVP100) (P100) 410 e-114
sp|Q14764|MVP_HUMAN Major vault protein (MVP) (Lung resista... 404 e-112
sp|Q62667|MVP_RAT Major vault protein (MVP) 398 e-110
sp|Q9EQK5|MVP_MOUSE Major vault protein (MVP) 396 e-110
sp|P54659|MVPB_DICDI Major vault protein beta (MVP-beta) 347 3e-95
sp|P19934|TOLA_ECOLI Protein tolA 53 1e-06
sp|Q9UL16|CCDCJ_HUMAN Coiled-coil domain-containing protein... 41 0.004
sp|Q8XZV6|IF2_RALSO Translation initiation factor IF-2 41 0.005
>sp|Q9DGM7|MVP_ICTPU Major vault protein (MVP)
Length = 871
Score = 423 bits (1087), Expect = e-118
Identities = 213/298 (71%), Positives = 249/298 (83%)
Frame = +3
Query: 3 VTYRVPHNAAVQIYDYKEKTARIHYGPDLVMLGPDEHFTQLSLSGGKPKKPNLIKSLCLL 182
V+YRVPHNAAVQ+YDY+EK AR+ +GPDLVMLGPDE FT LSLSG KPK+ N+IK++CLL
Sbjct: 483 VSYRVPHNAAVQVYDYREKKARVVFGPDLVMLGPDEQFTVLSLSGEKPKRANVIKAICLL 542
Query: 183 LGPDFCTDIIVVETSDHARLSLQVSYNWHFKTEAEKTQNTGTKLFSVPDFVGDACKALAS 362
LGPDFCTDII +ET+DHARL LQ++YNWHF+ + LFSVPDFVGDACKA+AS
Sbjct: 543 LGPDFCTDIITIETADHARLQLQLAYNWHFEVKNHSDPAQAAALFSVPDFVGDACKAIAS 602
Query: 363 RIRGTVAAVRFDDFHKNSARIIRSSVFGVDANNKVREEFVFPQNNLCITSIDIQSVEPVD 542
RIRG VA+V+FDDFHKNS RII S+VFG D VR F QN L I+S+DIQSVEPVD
Sbjct: 603 RIRGAVASVQFDDFHKNSIRIICSAVFGFDEKLAVRSSLRFNQNGLVISSVDIQSVEPVD 662
Query: 543 QRTRESLQKSVQLAIEITTKSQEASARHEADRIEQQAKGRLERQMITDQAEAERTRTELL 722
QRTR++LQKSVQLAIEITT SQEA+ARHEA+R+EQ+A+G+LERQ ITDQAEAER R ELL
Sbjct: 663 QRTRDALQKSVQLAIEITTNSQEATARHEAERLEQEARGKLERQKITDQAEAERARKELL 722
Query: 723 QLRAASAAVESTGQAKAEAQSRAEASRIEGEANVEQAKLKAEATTIEAENELARVIAA 896
+L A SAAVESTG AKAEAQSRAEA+RI+GEA V++AKLK EA IEAE E+ R+ A
Sbjct: 723 ELEALSAAVESTGAAKAEAQSRAEAARIQGEAAVQEAKLKVEALRIEAEAEMVRLAKA 780
>sp|P34118|MVPA_DICDI Major vault protein alpha (MVP-alpha)
Length = 843
Score = 412 bits (1058), Expect = e-115
Identities = 205/293 (69%), Positives = 249/293 (84%)
Frame = +3
Query: 3 VTYRVPHNAAVQIYDYKEKTARIHYGPDLVMLGPDEHFTQLSLSGGKPKKPNLIKSLCLL 182
VTYR PHN+AVQIYDYKEK +R+ +GPDLVMLGPDEHFT LSLSG KPK+P+ IK++ L
Sbjct: 443 VTYRAPHNSAVQIYDYKEKKSRVVFGPDLVMLGPDEHFTVLSLSGDKPKRPHQIKAIALF 502
Query: 183 LGPDFCTDIIVVETSDHARLSLQVSYNWHFKTEAEKTQNTGTKLFSVPDFVGDACKALAS 362
LGPDF TD+++VETSDHARLSL++SYNW FK + K ++ K+F VPDFVGD+CKA+AS
Sbjct: 503 LGPDFMTDVVIVETSDHARLSLKLSYNWEFKVDRSKIEDA-QKIFQVPDFVGDSCKAIAS 561
Query: 363 RIRGTVAAVRFDDFHKNSARIIRSSVFGVDANNKVREEFVFPQNNLCITSIDIQSVEPVD 542
R+RG VAAV FDDFHK SA +IR SVFG+D + +VR+ F F NNL IT+IDIQSVEPVD
Sbjct: 562 RVRGAVAAVSFDDFHKRSAEVIRQSVFGLDESGEVRKNFSFNSNNLVITNIDIQSVEPVD 621
Query: 543 QRTRESLQKSVQLAIEITTKSQEASARHEADRIEQQAKGRLERQMITDQAEAERTRTELL 722
QRTR+SLQKSVQLAIEITTKSQEA+ARHEA+R+EQ A+GRLERQ I D+A+AE R +LL
Sbjct: 622 QRTRDSLQKSVQLAIEITTKSQEAAARHEAERLEQGARGRLERQKIHDEAQAELARKDLL 681
Query: 723 QLRAASAAVESTGQAKAEAQSRAEASRIEGEANVEQAKLKAEATTIEAENELA 881
QL+A SAAVESTGQA AEAQ+ AEA+ I EANV+QA+LKA+AT I +E+E++
Sbjct: 682 QLQAQSAAVESTGQATAEAQATAEAANIAAEANVKQAELKAQATKIRSESEIS 734
>sp|Q90405|MVP_DISOM Major vault protein (MVP100) (P100)
Length = 852
Score = 410 bits (1055), Expect = e-114
Identities = 204/298 (68%), Positives = 249/298 (83%)
Frame = +3
Query: 3 VTYRVPHNAAVQIYDYKEKTARIHYGPDLVMLGPDEHFTQLSLSGGKPKKPNLIKSLCLL 182
VT+RVPHNAAVQ+YDY +K+AR+ +GP+LVML DE T LSLSGG+PK+P +I+SLCLL
Sbjct: 458 VTFRVPHNAAVQVYDYSQKSARVVFGPELVMLETDEQLTVLSLSGGRPKRPGVIRSLCLL 517
Query: 183 LGPDFCTDIIVVETSDHARLSLQVSYNWHFKTEAEKTQNTGTKLFSVPDFVGDACKALAS 362
LGPDF TD+IV+ET+DHARL LQ++YNWHF+ + K+FSV DFVGDACKA+AS
Sbjct: 518 LGPDFFTDVIVIETADHARLQLQLAYNWHFEVKDRSDPMESAKVFSVLDFVGDACKAIAS 577
Query: 363 RIRGTVAAVRFDDFHKNSARIIRSSVFGVDANNKVREEFVFPQNNLCITSIDIQSVEPVD 542
RIRG VA+V+FDDFHKNS+RI+R++VFG+D +VRE +FPQN+LC+TS+D+ SVEPVD
Sbjct: 578 RIRGAVASVQFDDFHKNSSRILRAAVFGLDPELRVRERLLFPQNSLCVTSVDVHSVEPVD 637
Query: 543 QRTRESLQKSVQLAIEITTKSQEASARHEADRIEQQAKGRLERQMITDQAEAERTRTELL 722
QRTR++LQ+SVQLAIEITTKSQEA+AR EA R+EQ+AKGRLERQ I DQAE+ER R ELL
Sbjct: 638 QRTRDALQRSVQLAIEITTKSQEAAARQEAARLEQEAKGRLERQRILDQAESERARRELL 697
Query: 723 QLRAASAAVESTGQAKAEAQSRAEASRIEGEANVEQAKLKAEATTIEAENELARVIAA 896
L A S AVES G A+AEA+SRAEASRIEGE +V QAKLKA+A IE E EL R+ A
Sbjct: 698 LLEADSTAVESRGAARAEAESRAEASRIEGEGSVLQAKLKAQALDIETEAELERLTKA 755
>sp|Q14764|MVP_HUMAN Major vault protein (MVP) (Lung resistance-related protein)
Length = 893
Score = 404 bits (1038), Expect = e-112
Identities = 201/305 (65%), Positives = 248/305 (81%), Gaps = 10/305 (3%)
Frame = +3
Query: 3 VTYRVPHNAAVQIYDYKEKTARIHYGPDLVMLGPDEHFTQLSLSGGKPKKPNLIKSLCLL 182
V+YRVPHNAAVQ+YDY+EK AR+ +GP+LV LGP+E FT LSLS G+PK+P+ ++LCLL
Sbjct: 458 VSYRVPHNAAVQVYDYREKRARVVFGPELVSLGPEEQFTVLSLSAGRPKRPHARRALCLL 517
Query: 183 LGPDFCTDIIVVETSDHARLSLQVSYNWHFKTEAEKTQNTGTKLFSVPDFVGDACKALAS 362
LGPDF TD+I +ET+DHARL LQ++YNWHF+ K KLFSVPDFVGDACKA+AS
Sbjct: 518 LGPDFFTDVITIETADHARLQLQLAYNWHFEVNDRKDPQETAKLFSVPDFVGDACKAIAS 577
Query: 363 RIRGTVAAVRFDDFHKNSARIIRSSVFGVDANN----------KVREEFVFPQNNLCITS 512
R+RG VA+V FDDFHKNSARIIR++VFG + + + R++ VFPQN L ++S
Sbjct: 578 RVRGAVASVTFDDFHKNSARIIRTAVFGFETSEAKGPDGMALPRPRDQAVFPQNGLVVSS 637
Query: 513 IDIQSVEPVDQRTRESLQKSVQLAIEITTKSQEASARHEADRIEQQAKGRLERQMITDQA 692
+D+QSVEPVDQRTR++LQ+SVQLAIEITT SQEA+A+HEA R+EQ+A+GRLERQ I DQ+
Sbjct: 638 VDVQSVEPVDQRTRDALQRSVQLAIEITTNSQEAAAKHEAQRLEQEARGRLERQKILDQS 697
Query: 693 EAERTRTELLQLRAASAAVESTGQAKAEAQSRAEASRIEGEANVEQAKLKAEATTIEAEN 872
EAE+ R ELL+L A S AVESTG AKAEA+SRAEA+RIEGE +V QAKLKA+A IE E
Sbjct: 698 EAEKARKELLELEALSMAVESTGTAKAEAESRAEAARIEGEGSVLQAKLKAQALAIETEA 757
Query: 873 ELARV 887
EL RV
Sbjct: 758 ELQRV 762
>sp|Q62667|MVP_RAT Major vault protein (MVP)
Length = 861
Score = 398 bits (1023), Expect = e-110
Identities = 199/305 (65%), Positives = 245/305 (80%), Gaps = 10/305 (3%)
Frame = +3
Query: 3 VTYRVPHNAAVQIYDYKEKTARIHYGPDLVMLGPDEHFTQLSLSGGKPKKPNLIKSLCLL 182
V+YRVPHNAAVQ+YDY+ K AR+ +GP+LV L P+E FT LSLS G+PK+P+ ++LCLL
Sbjct: 458 VSYRVPHNAAVQVYDYRAKRARVVFGPELVTLDPEEQFTVLSLSAGRPKRPHARRALCLL 517
Query: 183 LGPDFCTDIIVVETSDHARLSLQVSYNWHFKTEAEKTQNTGTKLFSVPDFVGDACKALAS 362
LGPDF TD+I +ET+DHARL LQ++YNWHF+ + KLFSVPDFVGDACKA+AS
Sbjct: 518 LGPDFFTDVITIETADHARLQLQLAYNWHFELKNRNDPAEAAKLFSVPDFVGDACKAIAS 577
Query: 363 RIRGTVAAVRFDDFHKNSARIIRSSVFGVDANN----------KVREEFVFPQNNLCITS 512
R+RG VA+V FDDFHKNSARIIR +VFG + + K R++ VFPQN L ++S
Sbjct: 578 RVRGAVASVTFDDFHKNSARIIRMAVFGFEMSEDTGPDGTLLPKARDQAVFPQNGLVVSS 637
Query: 513 IDIQSVEPVDQRTRESLQKSVQLAIEITTKSQEASARHEADRIEQQAKGRLERQMITDQA 692
+D+QSVEPVDQRTR++LQ+SVQLAIEITT SQEA+A+HEA R+EQ+A+GRLERQ I DQ+
Sbjct: 638 VDVQSVEPVDQRTRDALQRSVQLAIEITTNSQEAAAKHEAQRLEQEARGRLERQKILDQS 697
Query: 693 EAERTRTELLQLRAASAAVESTGQAKAEAQSRAEASRIEGEANVEQAKLKAEATTIEAEN 872
EAE+ R ELL+L A S AVESTG AKAEA+SRAEA+RIEGE +V QAKLKA+A IE E
Sbjct: 698 EAEKARKELLELEAMSMAVESTGNAKAEAESRAEAARIEGEGSVLQAKLKAQALAIETEA 757
Query: 873 ELARV 887
EL RV
Sbjct: 758 ELERV 762
>sp|Q9EQK5|MVP_MOUSE Major vault protein (MVP)
Length = 861
Score = 396 bits (1018), Expect = e-110
Identities = 198/305 (64%), Positives = 244/305 (80%), Gaps = 10/305 (3%)
Frame = +3
Query: 3 VTYRVPHNAAVQIYDYKEKTARIHYGPDLVMLGPDEHFTQLSLSGGKPKKPNLIKSLCLL 182
V+YRVPHNAAVQ+YDY+ K AR+ +GP+LV L P+E FT LSLS G+PK+P+ ++LCLL
Sbjct: 458 VSYRVPHNAAVQVYDYRAKRARVVFGPELVSLDPEEQFTVLSLSAGRPKRPHARRALCLL 517
Query: 183 LGPDFCTDIIVVETSDHARLSLQVSYNWHFKTEAEKTQNTGTKLFSVPDFVGDACKALAS 362
LGPDF TD+I +ET+DHARL LQ++YNWHF+ + KLFSVPDFVGDACKA+AS
Sbjct: 518 LGPDFFTDVITIETADHARLQLQLAYNWHFELKNRNDPEETAKLFSVPDFVGDACKAIAS 577
Query: 363 RIRGTVAAVRFDDFHKNSARIIRSSVFGVDANN----------KVREEFVFPQNNLCITS 512
R+RG VA+V FDDFHKNSARIIR +VFG + + + R+ VFPQN L ++S
Sbjct: 578 RVRGAVASVTFDDFHKNSARIIRMAVFGFEMSEDAGPDGALLPRARDRAVFPQNGLVVSS 637
Query: 513 IDIQSVEPVDQRTRESLQKSVQLAIEITTKSQEASARHEADRIEQQAKGRLERQMITDQA 692
+D+QSVEPVDQRTR++LQ+SVQLAIEITT SQEA+A+HEA R+EQ+A+GRLERQ I DQ+
Sbjct: 638 VDVQSVEPVDQRTRDALQRSVQLAIEITTNSQEAAAKHEAQRLEQEARGRLERQKILDQS 697
Query: 693 EAERTRTELLQLRAASAAVESTGQAKAEAQSRAEASRIEGEANVEQAKLKAEATTIEAEN 872
EAE+ R ELL+L A S AVESTG AKAEA+SRAEA+RIEGE +V QAKLKA+A IE E
Sbjct: 698 EAEKARKELLELEAMSMAVESTGNAKAEAESRAEAARIEGEGSVLQAKLKAQALAIETEA 757
Query: 873 ELARV 887
EL RV
Sbjct: 758 ELERV 762
>sp|P54659|MVPB_DICDI Major vault protein beta (MVP-beta)
Length = 846
Score = 347 bits (889), Expect = 3e-95
Identities = 181/297 (60%), Positives = 229/297 (77%)
Frame = +3
Query: 3 VTYRVPHNAAVQIYDYKEKTARIHYGPDLVMLGPDEHFTQLSLSGGKPKKPNLIKSLCLL 182
+TYRVPHNAAVQI+DY++K AR+ +GP+LVML PDE FT LSLSG PK+PN I+SL L
Sbjct: 459 ITYRVPHNAAVQIFDYRKKEARVVFGPELVMLEPDEEFTVLSLSGKIPKRPNHIRSLALF 518
Query: 183 LGPDFCTDIIVVETSDHARLSLQVSYNWHFKTEAEKTQNTGTKLFSVPDFVGDACKALAS 362
LGPDF TD+I VET+DHARLSL++SYNWHFK E Q+ +KLF+ DF GD CKA S
Sbjct: 519 LGPDFMTDLITVETADHARLSLKLSYNWHFKVE----QDNPSKLFATSDFTGDLCKATGS 574
Query: 363 RIRGTVAAVRFDDFHKNSARIIRSSVFGVDANNKVREEFVFPQNNLCITSIDIQSVEPVD 542
+R VAA FD+FHK+S+ II+ +VFG + + F N L IT+ID+QSVEPVD
Sbjct: 575 LVRAAVAASTFDNFHKHSSDIIQQAVFG-STDGSSNDCLYFETNGLVITNIDVQSVEPVD 633
Query: 543 QRTRESLQKSVQLAIEITTKSQEASARHEADRIEQQAKGRLERQMITDQAEAERTRTELL 722
QRT +SLQKSVQLAIEITTKSQEA+AR EA+R+EQ A+G LERQ I D+A+ E +R++L+
Sbjct: 634 QRTLDSLQKSVQLAIEITTKSQEATARQEAERLEQMARGELERQKIIDEAKNEESRSKLV 693
Query: 723 QLRAASAAVESTGQAKAEAQSRAEASRIEGEANVEQAKLKAEATTIEAENELARVIA 893
QL+A SAAVESTGQA AEA++RAEA+ IE E+ ++QA+L A IEA +E+ + A
Sbjct: 694 QLQAQSAAVESTGQAVAEARARAEAAIIEAESEIKQARLSTRAIEIEALSEIENLKA 750
>sp|P19934|TOLA_ECOLI Protein tolA
Length = 421
Score = 52.8 bits (125), Expect = 1e-06
Identities = 40/119 (33%), Positives = 59/119 (49%)
Frame = +3
Query: 519 IQSVEPVDQRTRESLQKSVQLAIEITTKSQEASARHEADRIEQQAKGRLERQMITDQAEA 698
+QS E +R+ E + Q A E + Q A E +R++Q K RL Q QAE
Sbjct: 67 MQSQESSAKRSDEQRKMKEQQAAEELREKQAA----EQERLKQLEKERLAAQEQKKQAEE 122
Query: 699 ERTRTELLQLRAASAAVESTGQAKAEAQSRAEASRIEGEANVEQAKLKAEATTIEAENE 875
+ EL Q +A AA ++ AKA+A++ A+A+ + AK KAEA +A E
Sbjct: 123 AAKQAELKQKQAEEAAAKAAADAKAKAEADAKAAEEAAKKAAADAKKKAEAEAAKAAAE 181
Score = 32.3 bits (72), Expect = 1.8
Identities = 28/98 (28%), Positives = 42/98 (42%)
Frame = +3
Query: 555 ESLQKSVQLAIEITTKSQEASARHEADRIEQQAKGRLERQMITDQAEAERTRTELLQLRA 734
E QK + A +A A +A E+ AK +AEA + E Q +A
Sbjct: 128 ELKQKQAEEAAAKAAADAKAKAEADAKAAEEAAKKAAADAKKKAEAEAAKAAAE-AQKKA 186
Query: 735 ASAAVESTGQAKAEAQSRAEASRIEGEANVEQAKLKAE 848
+AA +A+A + AEA + E+AK +AE
Sbjct: 187 EAAAAALKKKAEAAEAAAAEARKKAATEAAEKAKAEAE 224
>sp|Q9UL16|CCDCJ_HUMAN Coiled-coil domain-containing protein 19 (Nasopharyngeal
epithelium-specific protein 1)
Length = 386
Score = 41.2 bits (95), Expect = 0.004
Identities = 27/105 (25%), Positives = 50/105 (47%), Gaps = 1/105 (0%)
Frame = +3
Query: 537 VDQRTRESLQKSVQLAIEITTKSQEASARHEADRIEQQAKGRLERQMITDQAEAERTR-T 713
+DQ QKS+Q E+ K +E R +EQ K + ER ++ +Q E E+ +
Sbjct: 90 LDQMMEVERQKSIQRQEELERKRREERIRGRRQIVEQMEKNQEERSLLAEQREQEKEQML 149
Query: 714 ELLQLRAASAAVESTGQAKAEAQSRAEASRIEGEANVEQAKLKAE 848
E ++ + + + + + +AE RI E ++A+L A+
Sbjct: 150 EYMEQLQEEDLKDMERRQQQKLKMQAEIKRINDENQKQKAELLAQ 194
>sp|Q8XZV6|IF2_RALSO Translation initiation factor IF-2
Length = 964
Score = 40.8 bits (94), Expect = 0.005
Identities = 35/133 (26%), Positives = 56/133 (42%), Gaps = 6/133 (4%)
Frame = +3
Query: 513 IDIQSVEPVDQRTRESLQKSVQLAIEITTKSQEASARHEADRIEQQAKGRLERQMITDQA 692
+D++ V ++ R + + E+ + QEA R EA+R +Q E++ + A
Sbjct: 121 VDVEEVARREEEQRRQAELLARQEAELKAR-QEAMEREEAERRARQEAAEAEQRRQAELA 179
Query: 693 EAERTRTELLQLRAASAAVESTGQAKAE------AQSRAEASRIEGEANVEQAKLKAEAT 854
A++ E RAA+ A + + KAE A R A + EA K+KAE
Sbjct: 180 -AKKAEEEAAAARAAAEASDEAPRRKAEEDAARLASEREAAQKAAEEARAAADKIKAEED 238
Query: 855 TIEAENELARVIA 893
E A A
Sbjct: 239 GARKRREAAEAEA 251
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 88,179,517
Number of Sequences: 369166
Number of extensions: 1669518
Number of successful extensions: 5567
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 5335
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 5520
length of database: 68,354,980
effective HSP length: 110
effective length of database: 48,034,130
effective search space used: 9030416440
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)