Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_025_M21
(873 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|O18767|MMP20_BOVIN Matrix metalloproteinase-20 precursor... 128 2e-29
sp|O60882|MMP20_HUMAN Matrix metalloproteinase-20 precursor... 127 3e-29
sp|P79287|MMP20_PIG Matrix metalloproteinase-20 precursor (... 127 5e-29
sp|P57748|MMP20_MOUSE Matrix metalloproteinase-20 precursor... 125 1e-28
sp|Q9R0S2|MMP24_MOUSE Matrix metalloproteinase-24 precursor... 120 6e-27
sp|Q99PW6|MMP24_RAT Matrix metalloproteinase-24 precursor (... 120 6e-27
sp|Q9JHI0|MMP19_MOUSE Matrix metalloproteinase-19 precursor... 119 1e-26
sp|Q9Y5R2|MMP24_HUMAN Matrix metalloproteinase-24 precursor... 118 2e-26
sp|O77656|MMP13_BOVIN Collagenase 3 precursor (Matrix metal... 117 3e-26
sp|O62806|MMP13_RABIT Collagenase 3 precursor (Matrix metal... 116 7e-26
>sp|O18767|MMP20_BOVIN Matrix metalloproteinase-20 precursor (MMP-20) (Enamel
metalloproteinase) (Enamelysin)
Length = 481
Score = 128 bits (321), Expect = 2e-29
Identities = 83/216 (38%), Positives = 115/216 (53%), Gaps = 4/216 (1%)
Frame = +1
Query: 4 GLPTDGKINKELLAHVGKSRCGGKDVKPKNKRYNAANSKWDKGT-TYRFYIHDERHPTTM 180
GL GK+++ + + + RCG DV N R KW K T TYR ++ +M
Sbjct: 78 GLRVTGKLDRATMDVIKRPRCGVPDVA--NYRLFPGEPKWKKNTLTYRI----SKYTPSM 131
Query: 181 TLGEIQRALMIGLSYWSTAGDIYFAKVSNKQGSMFSLSFADAEHVQYDVHNNFVESRDPY 360
T E+ RA+ + L WS+A + F +++ + + +SF +H D Y
Sbjct: 132 TPAEVDRAMEMALRAWSSAVPLNFVRINAGEADIM-ISFETGDH------------GDSY 178
Query: 361 PLDNVPGGVLAHAFFPRNG---NLHFDSAEEWTEGKEDGINLRLVAAHEMGHAIGLFHSN 531
P D P G LAHAF P G + HFD+AE+WT G +G NL VAAHE GHA+GL HS
Sbjct: 179 PFDG-PRGTLAHAFAPGEGLGGDTHFDNAEKWTMGT-NGFNLFTVAAHEFGHALGLAHST 236
Query: 532 DPNALMAPWYGGYISENDFKLPDDDSQGAAFIYGTK 639
DP+ALM P Y Y + F+LP DD +G +YG +
Sbjct: 237 DPSALMFPTY-KYQNPYGFRLPKDDVKGIQALYGPR 271
>sp|O60882|MMP20_HUMAN Matrix metalloproteinase-20 precursor (MMP-20) (Enamel
metalloproteinase) (Enamelysin)
Length = 483
Score = 127 bits (320), Expect = 3e-29
Identities = 85/222 (38%), Positives = 120/222 (54%), Gaps = 4/222 (1%)
Frame = +1
Query: 4 GLPTDGKINKELLAHVGKSRCGGKDVKPKNKRYNAANSKWDKGT-TYRFYIHDERHPTTM 180
GL GK+++ + + K RCG DV N R KW K T TYR ++ +M
Sbjct: 80 GLQVTGKLDQTTMNVIKKPRCGVPDVA--NYRLFPGEPKWKKNTLTYRI----SKYTPSM 133
Query: 181 TLGEIQRALMIGLSYWSTAGDIYFAKVSNKQGSMFSLSFADAEHVQYDVHNNFVESRDPY 360
+ E+ +A+ + L WS+A + F ++++ + + +SF + +H D Y
Sbjct: 134 SSVEVDKAVEMALQAWSSAVPLSFVRINSGEADIM-ISFENGDH------------GDSY 180
Query: 361 PLDNVPGGVLAHAFFPRNG---NLHFDSAEEWTEGKEDGINLRLVAAHEMGHAIGLFHSN 531
P D P G LAHAF P G + HFD+AE+WT G +G NL VAAHE GHA+GL HS
Sbjct: 181 PFDG-PRGTLAHAFAPGEGLGGDTHFDNAEKWTMGT-NGFNLFTVAAHEFGHALGLAHST 238
Query: 532 DPNALMAPWYGGYISENDFKLPDDDSQGAAFIYGTKNGKVFV 657
DP+ALM P Y Y + F LP DD +G +YG + KVF+
Sbjct: 239 DPSALMYPTY-KYKNPYGFHLPKDDVKGIQALYGPR--KVFL 277
>sp|P79287|MMP20_PIG Matrix metalloproteinase-20 precursor (MMP-20) (Enamel
metalloproteinase) (Enamelysin)
Length = 483
Score = 127 bits (318), Expect = 5e-29
Identities = 89/247 (36%), Positives = 125/247 (50%), Gaps = 4/247 (1%)
Frame = +1
Query: 4 GLPTDGKINKELLAHVGKSRCGGKDVKPKNKRYNAANSKWDKGT-TYRFYIHDERHPTTM 180
GL GK+++ + + + RCG DV N R KW K T TYR ++ +M
Sbjct: 80 GLRVTGKLDRTTMDVIKRPRCGVPDVA--NYRLFPGEPKWKKNTLTYRI----SKYTPSM 133
Query: 181 TLGEIQRALMIGLSYWSTAGDIYFAKVSNKQGSMFSLSFADAEHVQYDVHNNFVESRDPY 360
T E+ +A+ + L WS+A + F +V+ + + +SF +H D Y
Sbjct: 134 TPAEVDKAMEMALQAWSSAVPLSFVRVNAGEADIM-ISFETGDH------------GDSY 180
Query: 361 PLDNVPGGVLAHAFFPRNG---NLHFDSAEEWTEGKEDGINLRLVAAHEMGHAIGLFHSN 531
P D P G LAHAF P G + HFD+AE+WT G +G NL VAAHE GHA+GL HS
Sbjct: 181 PFDG-PRGTLAHAFAPGEGLGGDTHFDNAEKWTMGM-NGFNLFTVAAHEFGHALGLAHST 238
Query: 532 DPNALMAPWYGGYISENDFKLPDDDSQGAAFIYGTKNGKVFVRSNKKREQSANEKELCNI 711
DP+ALM P Y Y + F LP DD +G +YG + K F + L +I
Sbjct: 239 DPSALMYPTY-KYQNPYGFHLPKDDVKGIQALYGPR--KTFTGKPTVPHGPPHNPSLPDI 295
Query: 712 TNINSAF 732
+ +S+F
Sbjct: 296 CDSSSSF 302
>sp|P57748|MMP20_MOUSE Matrix metalloproteinase-20 precursor (MMP-20) (Enamel
metalloproteinase) (Enamelysin)
Length = 482
Score = 125 bits (315), Expect = 1e-28
Identities = 84/221 (38%), Positives = 117/221 (52%), Gaps = 4/221 (1%)
Frame = +1
Query: 4 GLPTDGKINKELLAHVGKSRCGGKDVKPKNKRYNAANSKWDKGT-TYRFYIHDERHPTTM 180
GL GK+++ + + K RCG DV N R KW K TYR ++ +M
Sbjct: 79 GLKVTGKLDQNTMNVIKKPRCGVPDVA--NYRLFPGEPKWKKNILTYRI----SKYTPSM 132
Query: 181 TLGEIQRALMIGLSYWSTAGDIYFAKVSNKQGSMFSLSFADAEHVQYDVHNNFVESRDPY 360
+ E+ +A+ + L WSTA + F ++++ + + +SF +H D Y
Sbjct: 133 SPTEVDKAIQMALHAWSTAVPLNFVRINSGEADIM-ISFETGDH------------GDSY 179
Query: 361 PLDNVPGGVLAHAFFPRNG---NLHFDSAEEWTEGKEDGINLRLVAAHEMGHAIGLFHSN 531
P D P G LAHAF P G + HFD+AE+WT G +G NL VAAHE GHA+GL HS
Sbjct: 180 PFDG-PRGTLAHAFAPGEGLGGDTHFDNAEKWTMGT-NGFNLFTVAAHEFGHALGLGHST 237
Query: 532 DPNALMAPWYGGYISENDFKLPDDDSQGAAFIYGTKNGKVF 654
DP+ALM P Y Y + F LP DD +G +YG + K+F
Sbjct: 238 DPSALMYPTY-KYQNPYRFHLPKDDVKGIQALYGPR--KIF 275
>sp|Q9R0S2|MMP24_MOUSE Matrix metalloproteinase-24 precursor (MMP-24) (Membrane-type
matrix metalloproteinase 5) (MT-MMP 5) (Membrane-type-5
matrix metalloproteinase) (MT5-MMP) (MMP-21)
Length = 618
Score = 120 bits (300), Expect = 6e-27
Identities = 84/229 (36%), Positives = 115/229 (50%), Gaps = 19/229 (8%)
Frame = +1
Query: 4 GLPTDGKINKELLAHVGKSRCGGKDV-----KPKNKRYNAANSKW-DKGTTYRFYIHDER 165
G+P G +++ + + K RCG D + +NKRY KW K TY
Sbjct: 92 GIPVTGVLDQTTIEWMKKPRCGVPDHPHLSRRRRNKRYALTGQKWRQKHITYSI------ 145
Query: 166 HPTTMTLGEI--QRALMIGLSYWSTAGDIYFAKV------SNKQGSMFSLSFADAEHVQY 321
H T +GE+ ++A+ W + F +V S+++ + + FA H
Sbjct: 146 HNYTPKVGELDTRKAIRQAFDVWQKVTPLTFEEVPYHEIKSDRKEADIMIFFASGFH--- 202
Query: 322 DVHNNFVESRDPYPLDNVPGGVLAHAFFPR---NGNLHFDSAEEWTEGK--EDGINLRLV 486
D P D GG LAHA+FP G+ HFDS E WT G DG +L LV
Sbjct: 203 ---------GDSSPFDG-EGGFLAHAYFPGPGIGGDTHFDSDEPWTLGNANHDGNDLFLV 252
Query: 487 AAHEMGHAIGLFHSNDPNALMAPWYGGYISENDFKLPDDDSQGAAFIYG 633
A HE+GHA+GL HSNDP+A+MAP+Y Y+ ++FKLP DD QG IYG
Sbjct: 253 AVHELGHALGLEHSNDPSAIMAPFY-QYMETHNFKLPQDDLQGIQKIYG 300
>sp|Q99PW6|MMP24_RAT Matrix metalloproteinase-24 precursor (MMP-24) (Membrane-type
matrix metalloproteinase 5) (MT-MMP 5) (Membrane-type-5
matrix metalloproteinase) (MT5-MMP)
Length = 618
Score = 120 bits (300), Expect = 6e-27
Identities = 84/229 (36%), Positives = 115/229 (50%), Gaps = 19/229 (8%)
Frame = +1
Query: 4 GLPTDGKINKELLAHVGKSRCGGKDV-----KPKNKRYNAANSKW-DKGTTYRFYIHDER 165
G+P G +++ + + K RCG D + +NKRY KW K TY
Sbjct: 92 GIPVTGVLDQTTIEWMKKPRCGVPDHPHLSRRRRNKRYALTGQKWRQKHITYSI------ 145
Query: 166 HPTTMTLGEI--QRALMIGLSYWSTAGDIYFAKV------SNKQGSMFSLSFADAEHVQY 321
H T +GE+ ++A+ W + F +V S+++ + + FA H
Sbjct: 146 HNYTPKVGELDTRKAIRQAFDVWQKVTPLTFEEVPYHEIKSDRKEADIMIFFASGFH--- 202
Query: 322 DVHNNFVESRDPYPLDNVPGGVLAHAFFPR---NGNLHFDSAEEWTEGK--EDGINLRLV 486
D P D GG LAHA+FP G+ HFDS E WT G DG +L LV
Sbjct: 203 ---------GDSSPFDG-EGGFLAHAYFPGPGIGGDTHFDSDEPWTLGNANHDGNDLFLV 252
Query: 487 AAHEMGHAIGLFHSNDPNALMAPWYGGYISENDFKLPDDDSQGAAFIYG 633
A HE+GHA+GL HSNDP+A+MAP+Y Y+ ++FKLP DD QG IYG
Sbjct: 253 AVHELGHALGLEHSNDPSAIMAPFY-QYMETHNFKLPQDDLQGIQKIYG 300
>sp|Q9JHI0|MMP19_MOUSE Matrix metalloproteinase-19 precursor (MMP-19) (Matrix
metalloproteinase RASI)
Length = 527
Score = 119 bits (298), Expect = 1e-26
Identities = 77/215 (35%), Positives = 111/215 (51%), Gaps = 1/215 (0%)
Frame = +1
Query: 1 AGLPTDGKINKELLAHVGKSRCGGKD-VKPKNKRYNAANSKWDKGTTYRFYIHDERHPTT 177
+GLP G+++ A + + RCG +D K+ +Y K T+R + P+T
Sbjct: 65 SGLPISGQMDDATRARMKQPRCGLEDPFNQKSLKYLLLGHWRKKNLTFRIF----NVPST 120
Query: 178 MTLGEIQRALMIGLSYWSTAGDIYFAKVSNKQGSMFSLSFADAEHVQYDVHNNFVESRDP 357
++L ++ AL YWS+ + F +V + LSF + + N F
Sbjct: 121 LSLPRVRAALHQAFKYWSSVAPLTFREVKAGWADI-RLSFHGRQSLYCS--NTF------ 171
Query: 358 YPLDNVPGGVLAHAFFPRNGNLHFDSAEEWTEGKEDGINLRLVAAHEMGHAIGLFHSNDP 537
+ PG VLAHA P G++HFD E WTEG G+NLR++AAHE+GHA+GL HS
Sbjct: 172 ----DGPGKVLAHADIPELGSIHFDKDELWTEGTYQGVNLRIIAAHEVGHALGLGHSRYT 227
Query: 538 NALMAPWYGGYISENDFKLPDDDSQGAAFIYGTKN 642
ALMAP Y GY + FKL DD G +YG ++
Sbjct: 228 QALMAPVYAGY--QPFFKLHPDDVAGIQALYGKRS 260
>sp|Q9Y5R2|MMP24_HUMAN Matrix metalloproteinase-24 precursor (MMP-24) (Membrane-type
matrix metalloproteinase 5) (MT-MMP 5) (Membrane-type-5
matrix metalloproteinase) (MT5-MMP)
Length = 645
Score = 118 bits (295), Expect = 2e-26
Identities = 83/229 (36%), Positives = 115/229 (50%), Gaps = 19/229 (8%)
Frame = +1
Query: 4 GLPTDGKINKELLAHVGKSRCGGKDV-----KPKNKRYNAANSKW-DKGTTYRFYIHDER 165
G+P G +++ + + K RCG D + +NKRY KW K TY
Sbjct: 119 GIPVTGVLDQTTIEWMKKPRCGVPDHPHLSRRRRNKRYALTGQKWRQKHITYSI------ 172
Query: 166 HPTTMTLGEI--QRALMIGLSYWSTAGDIYFAKV------SNKQGSMFSLSFADAEHVQY 321
H T +GE+ ++A+ W + F +V S+++ + + FA H
Sbjct: 173 HNYTPKVGELDTRKAIRQAFDVWQKVTPLTFEEVPYHEIKSDRKEADIMIFFASGFH--- 229
Query: 322 DVHNNFVESRDPYPLDNVPGGVLAHAFFPR---NGNLHFDSAEEWTEGK--EDGINLRLV 486
D P D GG LAHA+FP G+ HFDS E WT G DG +L LV
Sbjct: 230 ---------GDSSPFDG-EGGFLAHAYFPGPGIGGDTHFDSDEPWTLGNANHDGNDLFLV 279
Query: 487 AAHEMGHAIGLFHSNDPNALMAPWYGGYISENDFKLPDDDSQGAAFIYG 633
A HE+GHA+GL HS+DP+A+MAP+Y Y+ ++FKLP DD QG IYG
Sbjct: 280 AVHELGHALGLEHSSDPSAIMAPFY-QYMETHNFKLPQDDLQGIQKIYG 327
>sp|O77656|MMP13_BOVIN Collagenase 3 precursor (Matrix metalloproteinase-13) (MMP-13)
Length = 471
Score = 117 bits (294), Expect = 3e-26
Identities = 90/286 (31%), Positives = 127/286 (44%), Gaps = 10/286 (3%)
Frame = +1
Query: 4 GLPTDGKINKELLAHVGKSRCGGKDVKPKNKRYNAANSKWDK-GTTYRFYIHDERHPTTM 180
GL G+++ L + K RCG DV N KW K TYR + +
Sbjct: 76 GLEVTGRLDDNTLDIMKKPRCGVPDVGEYN--VFPRTLKWSKMNLTYRIV----NYTPDL 129
Query: 181 TLGEIQRALMIGLSYWSTAGDIYFAKVSNKQGSMFSLSFADAEHVQYDVHNNFVESRDPY 360
T E+++A WS + F ++ N + +SF EH + Y
Sbjct: 130 THSEVEKAFRKAFKVWSDVTPLNFTRIHNGTADIM-ISFGTKEHGDF------------Y 176
Query: 361 PLDNVPGGVLAHAFFPR---NGNLHFDSAEEWTEGKEDGINLRLVAAHEMGHAIGLFHSN 531
P D P G+LAHAF P G+ HFD E WT + G NL LVAAHE GH++GL HS
Sbjct: 177 PFDG-PSGLLAHAFPPGPNYGGDAHFDDDETWTSSSK-GYNLFLVAAHEFGHSLGLDHSK 234
Query: 532 DPNALMAPWYGGYISENDFKLPDDDSQGAAFIYGTKNGKVFVRSNKKREQSANEKELCNI 711
DP ALM P Y Y ++ F LPDDD QG +YG + + + K ++ L I
Sbjct: 235 DPGALMFPIY-TYTGKSHFMLPDDDVQGIQSLYGPGDEDPYSKHPKTPDKCDPSLSLDAI 293
Query: 712 TNINSAFQYSDDNIYVVTDKNKVFRIIHSNNSF------RVDASFK 831
T++ D + +V + SF R+DA+++
Sbjct: 294 TSLRGETLIFKDRFFWRLHPQQVEAELFLTKSFGPELPNRIDAAYE 339
>sp|O62806|MMP13_RABIT Collagenase 3 precursor (Matrix metalloproteinase-13) (MMP-13)
Length = 471
Score = 116 bits (291), Expect = 7e-26
Identities = 90/286 (31%), Positives = 127/286 (44%), Gaps = 10/286 (3%)
Frame = +1
Query: 4 GLPTDGKINKELLAHVGKSRCGGKDVKPKNKRYNAANSKWDK-GTTYRFYIHDERHPTTM 180
GL GK++ LA + + RCG DV N KW + TYR + +
Sbjct: 76 GLEVTGKLDDNTLAIMKQPRCGVPDVGEYN--VFPRTLKWSQTNLTYRIV----NYTPDL 129
Query: 181 TLGEIQRALMIGLSYWSTAGDIYFAKVSNKQGSMFSLSFADAEHVQYDVHNNFVESRDPY 360
T E+++A WS + F ++ N + +SF EH + Y
Sbjct: 130 THSEVEKAFKKAFKVWSDVTPLNFTRIHNGTADIM-ISFGTKEHGDF------------Y 176
Query: 361 PLDNVPGGVLAHAFFPR---NGNLHFDSAEEWTEGKEDGINLRLVAAHEMGHAIGLFHSN 531
P D P G+LAHAF P G+ HFD E WT + G NL LVAAHE GH++GL HS
Sbjct: 177 PFDG-PSGLLAHAFPPGPNYGGDAHFDDDETWTSSSK-GYNLFLVAAHEFGHSLGLDHSK 234
Query: 532 DPNALMAPWYGGYISENDFKLPDDDSQGAAFIYGTKNGKVFVRSNKKREQSANEKELCNI 711
DP ALM P Y Y ++ F LPDDD QG +YG + + K ++ L I
Sbjct: 235 DPGALMFPIY-TYTGKSHFMLPDDDVQGIQSLYGPGDEDPNPKHPKTPDKCDPSLSLDAI 293
Query: 712 TNINSAFQYSDDNIYVVTDKNKVFRIIHSNNSF------RVDASFK 831
T++ D + +V + SF R+DA+++
Sbjct: 294 TSLRGETMIFKDRFFWRLHPQQVDAELFLTKSFWPELPNRIDAAYE 339
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.317 0.134 0.405
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 102,450,540
Number of Sequences: 369166
Number of extensions: 2204305
Number of successful extensions: 6475
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 5991
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 6280
length of database: 68,354,980
effective HSP length: 110
effective length of database: 48,034,130
effective search space used: 8646143400
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)