Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_025_L11
(500 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P10605|CATB_MOUSE Cathepsin B precursor (Cathepsin B1) [... 138 6e-33
sp|P07688|CATB_BOVIN Cathepsin B precursor [Contains: Cathe... 136 3e-32
sp|P00787|CATB_RAT Cathepsin B precursor (Cathepsin B1) (RS... 135 4e-32
sp|P43233|CATB_CHICK Cathepsin B precursor (Cathepsin B1) [... 134 2e-31
sp|P07858|CATB_HUMAN Cathepsin B precursor (Cathepsin B1) (... 130 2e-30
sp|P25792|CYSP_SCHMA Cathepsin B-like cysteine proteinase p... 122 4e-28
sp|P43157|CYSP_SCHJA Cathepsin B-like cysteine proteinase p... 122 4e-28
sp|P43507|CPR3_CAEEL Cathepsin B-like cysteine proteinase 3... 101 1e-21
sp|P43510|CPR6_CAEEL Cathepsin B-like cysteine proteinase 6... 100 3e-21
sp|P43508|CPR4_CAEEL Cathepsin B-like cysteine proteinase 4... 99 7e-21
>sp|P10605|CATB_MOUSE Cathepsin B precursor (Cathepsin B1) [Contains: Cathepsin B light
chain; Cathepsin B heavy chain]
Length = 339
Score = 138 bits (348), Expect = 6e-33
Identities = 72/131 (54%), Positives = 87/131 (66%), Gaps = 1/131 (0%)
Frame = +3
Query: 111 PIHTPLSFDLINYVNYVAHTTWKAGPTTRFQSISDIRKVLG-VMKDPNNFKLPKRKPLLN 287
P PLS DLINY+N +TTW+AG IS ++K+ G V+ P KLP R
Sbjct: 21 PSFHPLSDDLINYINK-QNTTWQAGRNFYNVDISYLKKLCGTVLGGP---KLPGRVAFGE 76
Query: 288 RVRLPTTFDARVQWPKCKSIGEIRDQSNCGSCWVFGAVEAITDRYCIHSNGTHTPRISAE 467
+ LP TFDAR QW C +IG+IRDQ +CGSCW FGAVEAI+DR CIH+NG +SAE
Sbjct: 77 DIDLPETFDAREQWSNCPTIGQIRDQGSCGSCWAFGAVEAISDRTCIHTNGRVNVEVSAE 136
Query: 468 DLLTCCGFRCG 500
DLLTCCG +CG
Sbjct: 137 DLLTCCGIQCG 147
>sp|P07688|CATB_BOVIN Cathepsin B precursor [Contains: Cathepsin B light chain; Cathepsin
B heavy chain]
Length = 335
Score = 136 bits (342), Expect = 3e-32
Identities = 69/127 (54%), Positives = 86/127 (67%), Gaps = 1/127 (0%)
Frame = +3
Query: 123 PLSFDLINYVNYVAHTTWKAGPTTRFQSISDIRKVLG-VMKDPNNFKLPKRKPLLNRVRL 299
PLS +L+N+VN +TTWKAG +S ++K+ G ++ P KLP+R V L
Sbjct: 25 PLSDELVNFVNK-QNTTWKAGHNFYNVDLSYVKKLCGAILGGP---KLPQRDAFAADVVL 80
Query: 300 PTTFDARVQWPKCKSIGEIRDQSNCGSCWVFGAVEAITDRYCIHSNGTHTPRISAEDLLT 479
P +FDAR QWP C +I EIRDQ +CGSCW FGAVEAI+DR CIHSNG +SAED+LT
Sbjct: 81 PESFDAREQWPNCPTIKEIRDQGSCGSCWAFGAVEAISDRICIHSNGRVNVEVSAEDMLT 140
Query: 480 CCGFRCG 500
CCG CG
Sbjct: 141 CCGGECG 147
>sp|P00787|CATB_RAT Cathepsin B precursor (Cathepsin B1) (RSG-2) [Contains: Cathepsin B
light chain; Cathepsin B heavy chain]
Length = 339
Score = 135 bits (341), Expect = 4e-32
Identities = 68/131 (51%), Positives = 87/131 (66%), Gaps = 1/131 (0%)
Frame = +3
Query: 111 PIHTPLSFDLINYVNYVAHTTWKAGPTTRFQSISDIRKVLG-VMKDPNNFKLPKRKPLLN 287
P PLS D+INY+N +TTW+AG IS ++K+ G V+ PN LP+R
Sbjct: 21 PSSHPLSDDMINYINK-QNTTWQAGRNFYNVDISYLKKLCGTVLGGPN---LPERVGFSE 76
Query: 288 RVRLPTTFDARVQWPKCKSIGEIRDQSNCGSCWVFGAVEAITDRYCIHSNGTHTPRISAE 467
+ LP +FDAR QW C +I +IRDQ +CGSCW FGAVEA++DR CIH+NG +SAE
Sbjct: 77 DINLPESFDAREQWSNCPTIAQIRDQGSCGSCWAFGAVEAMSDRICIHTNGRVNVEVSAE 136
Query: 468 DLLTCCGFRCG 500
DLLTCCG +CG
Sbjct: 137 DLLTCCGIQCG 147
>sp|P43233|CATB_CHICK Cathepsin B precursor (Cathepsin B1) [Contains: Cathepsin B light
chain; Cathepsin B heavy chain]
Length = 340
Score = 134 bits (336), Expect = 2e-31
Identities = 64/131 (48%), Positives = 85/131 (64%)
Frame = +3
Query: 108 IPIHTPLSFDLINYVNYVAHTTWKAGPTTRFQSISDIRKVLGVMKDPNNFKLPKRKPLLN 287
IP + PLS DL+N++N + +TT +AG +S ++K+ G K P+R
Sbjct: 20 IPYYPPLSSDLVNHINKL-NTTGRAGHNFHNTDMSYVKKLCGTFL--GGPKAPERVDFAE 76
Query: 288 RVRLPTTFDARVQWPKCKSIGEIRDQSNCGSCWVFGAVEAITDRYCIHSNGTHTPRISAE 467
+ LP TFD R QWP C +I EIRDQ +CGSCW FGAVEAI+DR C+H+N + +SAE
Sbjct: 77 DMDLPDTFDTRKQWPNCPTISEIRDQGSCGSCWAFGAVEAISDRICVHTNAKVSVEVSAE 136
Query: 468 DLLTCCGFRCG 500
DLL+CCGF CG
Sbjct: 137 DLLSCCGFECG 147
>sp|P07858|CATB_HUMAN Cathepsin B precursor (Cathepsin B1) (APP secretase) (APPS)
[Contains: Cathepsin B light chain; Cathepsin B heavy
chain]
Length = 339
Score = 130 bits (327), Expect = 2e-30
Identities = 65/130 (50%), Positives = 85/130 (65%)
Frame = +3
Query: 111 PIHTPLSFDLINYVNYVAHTTWKAGPTTRFQSISDIRKVLGVMKDPNNFKLPKRKPLLNR 290
P PLS +L+NYVN +TTW+AG +S ++++ G K P+R
Sbjct: 21 PSFHPLSDELVNYVNK-RNTTWQAGHNFYNVDMSYLKRLCGTFL--GGPKPPQRVMFTED 77
Query: 291 VRLPTTFDARVQWPKCKSIGEIRDQSNCGSCWVFGAVEAITDRYCIHSNGTHTPRISAED 470
++LP +FDAR QWP+C +I EIRDQ +CGSCW FGAVEAI+DR CIH+N + +SAED
Sbjct: 78 LKLPASFDAREQWPQCPTIKEIRDQGSCGSCWAFGAVEAISDRICIHTNAHVSVEVSAED 137
Query: 471 LLTCCGFRCG 500
LLTCCG CG
Sbjct: 138 LLTCCGSMCG 147
>sp|P25792|CYSP_SCHMA Cathepsin B-like cysteine proteinase precursor (Antigen Sm31)
Length = 340
Score = 122 bits (307), Expect = 4e-28
Identities = 59/125 (47%), Positives = 81/125 (64%), Gaps = 4/125 (3%)
Frame = +3
Query: 123 PLSFDLINYVNYVAHTTWKAGPTTRFQSISDIRKVLGVMKDPNNFKLPKRKPLLNR---- 290
PLS D+I+Y+N + W+A + RF S+ D R +G ++ + + KR+P ++
Sbjct: 28 PLSDDIISYINEHPNAGWRAEKSNRFHSLDDARIQMGARREEPDLRR-KRRPTVDHNDWN 86
Query: 291 VRLPTTFDARVQWPKCKSIGEIRDQSNCGSCWVFGAVEAITDRYCIHSNGTHTPRISAED 470
V +P+ FD+R +WP CKSI IRDQS CGSCW FGAVEA++DR CI S G +SA D
Sbjct: 87 VEIPSNFDSRKKWPGCKSIATIRDQSRCGSCWSFGAVEAMSDRSCIQSGGKQNVELSAVD 146
Query: 471 LLTCC 485
LLTCC
Sbjct: 147 LLTCC 151
>sp|P43157|CYSP_SCHJA Cathepsin B-like cysteine proteinase precursor (Antigen Sj31)
Length = 342
Score = 122 bits (307), Expect = 4e-28
Identities = 58/125 (46%), Positives = 81/125 (64%), Gaps = 4/125 (3%)
Frame = +3
Query: 123 PLSFDLINYVNYVAHTTWKAGPTTRFQSISDIRKVLGVMKDPNNFKLPKRKPLLNR---- 290
PLS ++I+++N WKA + RF S+ D R ++G K+ K R+P ++
Sbjct: 29 PLSDEMISFINEHPDAGWKADKSDRFHSLDDARILMGARKEDAEMKR-NRRPTVDHHDLN 87
Query: 291 VRLPTTFDARVQWPKCKSIGEIRDQSNCGSCWVFGAVEAITDRYCIHSNGTHTPRISAED 470
V +P+ FD+R +WP CKSI +IRDQS CGSCW FGAVEA+TDR CI S G + +SA D
Sbjct: 88 VEIPSQFDSRKKWPHCKSISQIRDQSRCGSCWAFGAVEAMTDRICIQSGGGQSAELSALD 147
Query: 471 LLTCC 485
L++CC
Sbjct: 148 LISCC 152
>sp|P43507|CPR3_CAEEL Cathepsin B-like cysteine proteinase 3 precursor (Cysteine
protease-related 3)
Length = 370
Score = 101 bits (251), Expect = 1e-21
Identities = 43/68 (63%), Positives = 50/68 (73%)
Frame = +3
Query: 297 LPTTFDARVQWPKCKSIGEIRDQSNCGSCWVFGAVEAITDRYCIHSNGTHTPRISAEDLL 476
LP TFDAR +WP C +I IR+Q+ CGSCW FGA E I+DR CI SNGT P IS ED+L
Sbjct: 92 LPDTFDAREKWPDCNTIKLIRNQATCGSCWAFGAAEVISDRVCIQSNGTQQPVISVEDIL 151
Query: 477 TCCGFRCG 500
+CCG CG
Sbjct: 152 SCCGTTCG 159
>sp|P43510|CPR6_CAEEL Cathepsin B-like cysteine proteinase 6 precursor (Cysteine
protease-related 6)
Length = 379
Score = 99.8 bits (247), Expect = 3e-21
Identities = 59/131 (45%), Positives = 78/131 (59%), Gaps = 10/131 (7%)
Frame = +3
Query: 135 DLINYVNYVAHTTWKAGPTTRFQSI-SDIRKVLGVMKDPNNFKLP-KRKPLLNRVR---- 296
DLI+YVN W A RF S+ + K + N+ +L K K L++ +
Sbjct: 45 DLIDYVNE-NQNLWTAKKQRRFSSVYGENDKAKWGLMGVNHVRLSVKGKQHLSKTKDLDL 103
Query: 297 -LPTTFDARVQWPKCKSIGEIRDQSNCGSCWVFGAVEAITDRYCIHSNGTHTPRISAEDL 473
+P +FD+R WPKC SI IRDQS+CGSCW FGAVEA++DR CI S+G +SA+DL
Sbjct: 104 DIPESFDSRDNWPKCDSIKVIRDQSSCGSCWAFGAVEAMSDRICIASHGELQVTLSADDL 163
Query: 474 LTC---CGFRC 497
L+C CGF C
Sbjct: 164 LSCCKSCGFGC 174
>sp|P43508|CPR4_CAEEL Cathepsin B-like cysteine proteinase 4 precursor (Cysteine
protease-related 4)
Length = 335
Score = 98.6 bits (244), Expect = 7e-21
Identities = 43/73 (58%), Positives = 51/73 (69%)
Frame = +3
Query: 282 LNRVRLPTTFDARVQWPKCKSIGEIRDQSNCGSCWVFGAVEAITDRYCIHSNGTHTPRIS 461
+N +P TFDAR QWP C SI IRDQS+CGSCW F A EA +DR+CI SNG +S
Sbjct: 76 INEDTIPATFDARTQWPNCMSINNIRDQSDCGSCWAFAAAEAASDRFCIASNGAVNTLLS 135
Query: 462 AEDLLTCCGFRCG 500
AED+L+CC CG
Sbjct: 136 AEDVLSCCS-NCG 147
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 58,848,737
Number of Sequences: 369166
Number of extensions: 1157220
Number of successful extensions: 3038
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 2960
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 3027
length of database: 68,354,980
effective HSP length: 102
effective length of database: 49,512,010
effective search space used: 3168768640
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)