Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_025_L06
(668 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q10991|CATL_SHEEP Cathepsin L [Contains: Cathepsin L hea... 241 1e-63
sp|Q95029|CATL_DROME Cathepsin L precursor (Cysteine protei... 241 2e-63
sp|Q26636|CATL_SARPE Cathepsin L precursor [Contains: Cathe... 239 4e-63
sp|P07711|CATL_HUMAN Cathepsin L precursor (Major excreted ... 239 6e-63
sp|P25782|CYSP2_HOMAM Digestive cysteine proteinase 2 precu... 238 8e-63
sp|O60911|CATL2_HUMAN Cathepsin L2 precursor (Cathepsin V) ... 237 2e-62
sp|P25975|CATL_BOVIN Cathepsin L precursor [Contains: Cathe... 237 2e-62
sp|Q9GL24|CATL_CANFA Cathepsin L precursor [Contains: Cathe... 236 5e-62
sp|P25784|CYSP3_HOMAM Digestive cysteine proteinase 3 precu... 234 2e-61
sp|Q28944|CATL_PIG Cathepsin L precursor [Contains: Catheps... 229 4e-60
>sp|Q10991|CATL_SHEEP Cathepsin L [Contains: Cathepsin L heavy chain; Cathepsin L light
chain]
Length = 217
Score = 241 bits (616), Expect = 1e-63
Identities = 121/201 (60%), Positives = 139/201 (69%), Gaps = 2/201 (0%)
Frame = +3
Query: 3 NQQQCGSCWSFSATGSLEGQYFRKNNRLISFSEQQLVDCSXXXXXXXXXXXLMDNAFRYI 182
NQ QCGSCW+FSATG+LEGQ FRK +L+S SEQ LVD S LMDNAF+YI
Sbjct: 18 NQGQCGSCWAFSATGALEGQMFRKTGKLVSLSEQNLVDSSRPQGNQGCNGGLMDNAFQYI 77
Query: 183 KDQ-GIESEGDYPYTATDGTCKRNPSKIVTKCTGFTDIQSQNETDLANAVATVGPVSVAI 359
K+ G++SE YPY ATD +C P K TGF DI Q E L AVATVGP+SVAI
Sbjct: 78 KENGGLDSEESYPYEATDTSCNYKPEYSAAKDTGFVDI-PQREKALMKAVATVGPISVAI 136
Query: 360 DAGHASFQLYKSGIYNEESCSTTQLDHGVLAVGYGTQ-IGKKYWIVKNSWDVTWGESGYI 536
DAGH+SFQ YKSGIY + CS+ LDHGVL VGYG + K+WIVKNSW WG GY+
Sbjct: 137 DAGHSSFQFYKSGIYYDPDCSSKDLDHGVLVVGYGFEGTNNKFWIVKNSWGPEWGNKGYV 196
Query: 537 KMSKDKKNQCGIATMASYPLV 599
KM+KD+ N CGIAT ASYP V
Sbjct: 197 KMAKDQNNHCGIATAASYPTV 217
>sp|Q95029|CATL_DROME Cathepsin L precursor (Cysteine proteinase 1) [Contains: Cathepsin
L heavy chain; Cathepsin L light chain]
Length = 341
Score = 241 bits (614), Expect = 2e-63
Identities = 116/201 (57%), Positives = 141/201 (70%), Gaps = 2/201 (0%)
Frame = +3
Query: 3 NQQQCGSCWSFSATGSLEGQYFRKNNRLISFSEQQLVDCSXXXXXXXXXXXLMDNAFRYI 182
+Q CGSCW+FS+TG+LEGQ+FRK+ L+S SEQ LVDCS LMDNAFRYI
Sbjct: 141 DQGHCGSCWAFSSTGALEGQHFRKSGVLVSLSEQNLVDCSTKYGNNGCNGGLMDNAFRYI 200
Query: 183 KDQG-IESEGDYPYTATDGTCKRNPSKIVTKCTGFTDIQSQNETDLANAVATVGPVSVAI 359
KD G I++E YPY A D +C N + GFTDI +E +A AVATVGPVSVAI
Sbjct: 201 KDNGGIDTEKSYPYEAIDDSCHFNKGTVGATDRGFTDIPQGDEKKMAEAVATVGPVSVAI 260
Query: 360 DAGHASFQLYKSGIYNEESCSTTQLDHGVLAVGYGT-QIGKKYWIVKNSWDVTWGESGYI 536
DA H SFQ Y G+YNE C LDHGVL VG+GT + G+ YW+VKNSW TWG+ G+I
Sbjct: 261 DASHESFQFYSEGVYNEPQCDAQNLDHGVLVVGFGTDESGEDYWLVKNSWGTTWGDKGFI 320
Query: 537 KMSKDKKNQCGIATMASYPLV 599
KM ++K+NQCGIA+ +SYPLV
Sbjct: 321 KMLRNKENQCGIASASSYPLV 341
>sp|Q26636|CATL_SARPE Cathepsin L precursor [Contains: Cathepsin L heavy chain; Cathepsin
L light chain]
Length = 339
Score = 239 bits (611), Expect = 4e-63
Identities = 117/201 (58%), Positives = 138/201 (68%), Gaps = 2/201 (0%)
Frame = +3
Query: 3 NQQQCGSCWSFSATGSLEGQYFRKNNRLISFSEQQLVDCSXXXXXXXXXXXLMDNAFRYI 182
+Q CGSCW+FS+TG+LEGQ+FRK L+S SEQ LVDCS LMDNAFRYI
Sbjct: 139 DQGHCGSCWAFSSTGALEGQHFRKAGVLVSLSEQNLVDCSTKYGNNGCNGGLMDNAFRYI 198
Query: 183 KDQG-IESEGDYPYTATDGTCKRNPSKIVTKCTGFTDIQSQNETDLANAVATVGPVSVAI 359
KD G I++E YPY D +C N + I TGF DI +E + AVAT+GPVSVAI
Sbjct: 199 KDNGGIDTEKSYPYEGIDDSCHFNKATIGATDTGFVDIPEGDEEKMKKAVATMGPVSVAI 258
Query: 360 DAGHASFQLYKSGIYNEESCSTTQLDHGVLAVGYGT-QIGKKYWIVKNSWDVTWGESGYI 536
DA H SFQLY G+YNE C LDHGVL VGYGT + G YW+VKNSW TWGE GYI
Sbjct: 259 DASHESFQLYSEGVYNEPECDEQNLDHGVLVVGYGTDESGMDYWLVKNSWGTTWGEQGYI 318
Query: 537 KMSKDKKNQCGIATMASYPLV 599
KM++++ NQCGIAT +SYP V
Sbjct: 319 KMARNQNNQCGIATASSYPTV 339
>sp|P07711|CATL_HUMAN Cathepsin L precursor (Major excreted protein) (MEP) [Contains:
Cathepsin L heavy chain; Cathepsin L light chain]
Length = 333
Score = 239 bits (609), Expect = 6e-63
Identities = 120/204 (58%), Positives = 139/204 (68%), Gaps = 5/204 (2%)
Frame = +3
Query: 3 NQQQCGSCWSFSATGSLEGQYFRKNNRLISFSEQQLVDCSXXXXXXXXXXXLMDNAFRYI 182
NQ QCGSCW+FSATG+LEGQ FRK RLIS SEQ LVDCS LMD AF+Y+
Sbjct: 131 NQGQCGSCWAFSATGALEGQMFRKTGRLISLSEQNLVDCSGPQGNEGCNGGLMDYAFQYV 190
Query: 183 KDQ-GIESEGDYPYTATDGTCKRNPSKIVTKCTGFTDIQSQNETDLANAVATVGPVSVAI 359
+D G++SE YPY AT+ +CK NP V TGF DI Q E L AVATVGP+SVAI
Sbjct: 191 QDNGGLDSEESYPYEATEESCKYNPKYSVANDTGFVDIPKQ-EKALMKAVATVGPISVAI 249
Query: 360 DAGHASFQLYKSGIYNEESCSTTQLDHGVLAVGYGTQI----GKKYWIVKNSWDVTWGES 527
DAGH SF YK GIY E CS+ +DHGVL VGYG + KYW+VKNSW WG
Sbjct: 250 DAGHESFLFYKEGIYFEPDCSSEDMDHGVLVVGYGFESTESDNNKYWLVKNSWGEEWGMG 309
Query: 528 GYIKMSKDKKNQCGIATMASYPLV 599
GY+KM+KD++N CGIA+ ASYP V
Sbjct: 310 GYVKMAKDRRNHCGIASAASYPTV 333
>sp|P25782|CYSP2_HOMAM Digestive cysteine proteinase 2 precursor
Length = 323
Score = 238 bits (608), Expect = 8e-63
Identities = 111/200 (55%), Positives = 145/200 (72%), Gaps = 1/200 (0%)
Frame = +3
Query: 3 NQQQCGSCWSFSATGSLEGQYFRKNNRLISFSEQQLVDCSXXXXXXXXXXXLMDNAFRYI 182
+Q QCGSCW+FS TGSLEGQ+F K LIS +EQQLVDCS M++AF YI
Sbjct: 124 DQGQCGSCWAFSTTGSLEGQHFLKTGSLISLAEQQLVDCSRPYGPQGCNGGWMNDAFDYI 183
Query: 183 K-DQGIESEGDYPYTATDGTCKRNPSKIVTKCTGFTDIQSQNETDLANAVATVGPVSVAI 359
K + GI++E YPY A DG+C+ + + + C+G T+I S +ET L AV +GP+SV I
Sbjct: 184 KANNGIDTEAAYPYEARDGSCRFDSNSVAATCSGHTNIASGSETGLQQAVRDIGPISVTI 243
Query: 360 DAGHASFQLYKSGIYNEESCSTTQLDHGVLAVGYGTQIGKKYWIVKNSWDVTWGESGYIK 539
DA H+SFQ Y SG+Y E SCS + LDH VLAVGYG++ G+ +W+VKNSW +WG++GYIK
Sbjct: 244 DAAHSSFQFYSSGVYYEPSCSPSYLDHAVLAVGYGSEGGQDFWLVKNSWATSWGDAGYIK 303
Query: 540 MSKDKKNQCGIATMASYPLV 599
MS+++ N CGIAT+ASYPLV
Sbjct: 304 MSRNRNNNCGIATVASYPLV 323
>sp|O60911|CATL2_HUMAN Cathepsin L2 precursor (Cathepsin V) (Cathepsin U)
Length = 334
Score = 237 bits (604), Expect = 2e-62
Identities = 116/204 (56%), Positives = 136/204 (66%), Gaps = 5/204 (2%)
Frame = +3
Query: 3 NQQQCGSCWSFSATGSLEGQYFRKNNRLISFSEQQLVDCSXXXXXXXXXXXLMDNAFRYI 182
NQ+QCGSCW+FSATG+LEGQ FRK +L+S SEQ LVDCS M AF+Y+
Sbjct: 131 NQKQCGSCWAFSATGALEGQMFRKTGKLVSLSEQNLVDCSRPQGNQGCNGGFMARAFQYV 190
Query: 183 KDQG-IESEGDYPYTATDGTCKRNPSKIVTKCTGFTDIQSQNETDLANAVATVGPVSVAI 359
K+ G ++SE YPY A D CK P V TGFT + E L AVATVGP+SVA+
Sbjct: 191 KENGGLDSEESYPYVAVDEICKYRPENSVANDTGFTVVAPGKEKALMKAVATVGPISVAM 250
Query: 360 DAGHASFQLYKSGIYNEESCSTTQLDHGVLAVGYG----TQIGKKYWIVKNSWDVTWGES 527
DAGH+SFQ YKSGIY E CS+ LDHGVL VGYG KYW+VKNSW WG +
Sbjct: 251 DAGHSSFQFYKSGIYFEPDCSSKNLDHGVLVVGYGFEGANSNNSKYWLVKNSWGPEWGSN 310
Query: 528 GYIKMSKDKKNQCGIATMASYPLV 599
GY+K++KDK N CGIAT ASYP V
Sbjct: 311 GYVKIAKDKNNHCGIATAASYPNV 334
>sp|P25975|CATL_BOVIN Cathepsin L precursor [Contains: Cathepsin L heavy chain; Cathepsin
L light chain]
Length = 334
Score = 237 bits (604), Expect = 2e-62
Identities = 122/205 (59%), Positives = 138/205 (67%), Gaps = 6/205 (2%)
Frame = +3
Query: 3 NQQQCGSCWSFSATGSLEGQYFRKNNRLISFSEQQLVDCSXXXXXXXXXXXLMDNAFRYI 182
NQ QCGSCW+FSATG+LEGQ FRK +L+S SEQ LVDCS LMDNAF+YI
Sbjct: 131 NQGQCGSCWAFSATGALEGQMFRKTGKLVSLSEQNLVDCSRAQGNQGCNGGLMDNAFQYI 190
Query: 183 KDQ-GIESEGDYPYTATD-GTCKRNPSKIVTKCTGFTDIQSQNETDLANAVATVGPVSVA 356
KD G++SE YPY ATD +C P TGF DI Q E L AVATVGP+SVA
Sbjct: 191 KDNGGLDSEESYPYLATDTNSCNYKPECSAANDTGFVDI-PQREKALMKAVATVGPISVA 249
Query: 357 IDAGHASFQLYKSGIYNEESCSTTQLDHGVLAVGYGTQ----IGKKYWIVKNSWDVTWGE 524
IDAGH SFQ YKSGIY + CS LDHGVL VGYG + K+WIVKNSW WG
Sbjct: 250 IDAGHTSFQFYKSGIYYDPDCSCKDLDHGVLVVGYGFEGTDSNNNKFWIVKNSWGPEWGW 309
Query: 525 SGYIKMSKDKKNQCGIATMASYPLV 599
+GY+KM+KD+ N CGIAT ASYP V
Sbjct: 310 NGYVKMAKDQNNHCGIATAASYPTV 334
>sp|Q9GL24|CATL_CANFA Cathepsin L precursor [Contains: Cathepsin L heavy chain; Cathepsin
L light chain]
Length = 333
Score = 236 bits (601), Expect = 5e-62
Identities = 120/204 (58%), Positives = 137/204 (67%), Gaps = 5/204 (2%)
Frame = +3
Query: 3 NQQQCGSCWSFSATGSLEGQYFRKNNRLISFSEQQLVDCSXXXXXXXXXXXLMDNAFRYI 182
NQ QCGSCW+FSATG+LEGQ FRK +L+S SEQ LVDCS LMDNAFRY+
Sbjct: 131 NQGQCGSCWAFSATGALEGQMFRKTGKLVSLSEQNLVDCSRAQGNEGCNGGLMDNAFRYV 190
Query: 183 KDQ-GIESEGDYPYTATD-GTCKRNPSKIVTKCTGFTDIQSQNETDLANAVATVGPVSVA 356
KD G++SE YPY D TC P TGF D+ Q E L AVAT+GP+SVA
Sbjct: 191 KDNGGLDSEESYPYLGRDTETCNYKPECSAANDTGFVDL-PQREKALMKAVATLGPISVA 249
Query: 357 IDAGHASFQLYKSGIYNEESCSTTQLDHGVLAVGY---GTQIGKKYWIVKNSWDVTWGES 527
IDAGH SFQ YKSGIY + CS+ LDHGVL VGY GT K+WIVKNSW WG +
Sbjct: 250 IDAGHQSFQFYKSGIYFDPDCSSKDLDHGVLVVGYGFEGTDSNNKFWIVKNSWGPEWGWN 309
Query: 528 GYIKMSKDKKNQCGIATMASYPLV 599
GY+KM+KD+ N CGIAT ASYP V
Sbjct: 310 GYVKMAKDQNNHCGIATAASYPTV 333
>sp|P25784|CYSP3_HOMAM Digestive cysteine proteinase 3 precursor
Length = 321
Score = 234 bits (597), Expect = 2e-61
Identities = 113/200 (56%), Positives = 143/200 (71%), Gaps = 1/200 (0%)
Frame = +3
Query: 3 NQQQCGSCWSFSATGSLEGQYFRKNNRLISFSEQQLVDCSXXXXXXXXXXXLMDNAFRYI 182
+Q+QCGSCW+FSATG+LEGQ+F KN+ L+S SEQQLVDCS M +AF YI
Sbjct: 123 DQEQCGSCWAFSATGALEGQHFLKNDELVSLSEQQLVDCSTDYGNDGCGGGWMTSAFDYI 182
Query: 183 KDQG-IESEGDYPYTATDGTCKRNPSKIVTKCTGFTDIQSQNETDLANAVATVGPVSVAI 359
KD G I++E YPY A D +C+ + + I CTG ++Q E L AV+ VGP+SVAI
Sbjct: 183 KDNGGIDTESSYPYEAEDRSCRFDANSIGAICTGSVEVQHTEEA-LQEAVSGVGPISVAI 241
Query: 360 DAGHASFQLYKSGIYNEESCSTTQLDHGVLAVGYGTQIGKKYWIVKNSWDVTWGESGYIK 539
DA H SFQ Y SG+Y E++CS T LDHGVLAVGYGT+ K YW+VKNSW +WG++GYIK
Sbjct: 242 DASHFSFQFYSSGVYYEQNCSPTFLDHGVLAVGYGTESTKDYWLVKNSWGSSWGDAGYIK 301
Query: 540 MSKDKKNQCGIATMASYPLV 599
MS+++ N CGIA+ SYP V
Sbjct: 302 MSRNRDNNCGIASEPSYPTV 321
>sp|Q28944|CATL_PIG Cathepsin L precursor [Contains: Cathepsin L heavy chain; Cathepsin
L light chain]
Length = 334
Score = 229 bits (585), Expect = 4e-60
Identities = 116/205 (56%), Positives = 138/205 (67%), Gaps = 6/205 (2%)
Frame = +3
Query: 3 NQQQCGSCWSFSATGSLEGQYFRKNNRLISFSEQQLVDCSXXXXXXXXXXXLMDNAFRYI 182
NQ QCGSCW+FSATG+LEGQ FRK +L+S SEQ LVDCS LMDNAF+Y+
Sbjct: 131 NQGQCGSCWAFSATGALEGQMFRKTGKLVSLSEQNLVDCSRPQGNQGCNGGLMDNAFQYV 190
Query: 183 KDQ-GIESEGDYPYTATD-GTCKRNPSKIVTKCTGFTDIQSQNETDLANAVATVGPVSVA 356
KD G+++E YPY + +C P TGF DI Q E L AVATVGP+SVA
Sbjct: 191 KDNGGLDTEESYPYLGRETNSCTYKPECSAANDTGFVDI-PQREKALMKAVATVGPISVA 249
Query: 357 IDAGHASFQLYKSGIYNEESCSTTQLDHGVLAVGYGTQ----IGKKYWIVKNSWDVTWGE 524
IDAGH+SFQ YKSGIY + CS+ LDHGVL VGYG + K+WIVKNSW WG
Sbjct: 250 IDAGHSSFQFYKSGIYYDPDCSSKDLDHGVLVVGYGFEGTDSNSSKFWIVKNSWGPEWGW 309
Query: 525 SGYIKMSKDKKNQCGIATMASYPLV 599
+GY+KM+KD+ N CGI+T ASYP V
Sbjct: 310 NGYVKMAKDQNNHCGISTAASYPTV 334
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 72,770,139
Number of Sequences: 369166
Number of extensions: 1384936
Number of successful extensions: 4468
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 3908
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 4023
length of database: 68,354,980
effective HSP length: 106
effective length of database: 48,773,070
effective search space used: 5657676120
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)