Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_025_L05
(534 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q9GL24|CATL_CANFA Cathepsin L precursor [Contains: Cathe... 177 1e-44
sp|Q28944|CATL_PIG Cathepsin L precursor [Contains: Catheps... 172 5e-43
sp|P07711|CATL_HUMAN Cathepsin L precursor (Major excreted ... 170 2e-42
sp|Q24940|CATLP_FASHE Cathepsin L-like proteinase precursor 169 3e-42
sp|P25975|CATL_BOVIN Cathepsin L precursor [Contains: Cathe... 169 3e-42
sp|O60911|CATL2_HUMAN Cathepsin L2 precursor (Cathepsin V) ... 168 7e-42
sp|P06797|CATL_MOUSE Cathepsin L precursor (Major excreted ... 159 4e-39
sp|P07154|CATL_RAT Cathepsin L precursor (Major excreted pr... 158 7e-39
sp|P61277|CATK_MACMU Cathepsin K precursor >gi|47117667|sp|... 157 2e-38
sp|P43236|CATK_RABIT Cathepsin K precursor (OC-2 protein) 156 3e-38
>sp|Q9GL24|CATL_CANFA Cathepsin L precursor [Contains: Cathepsin L heavy chain; Cathepsin
L light chain]
Length = 333
Score = 177 bits (449), Expect = 1e-44
Identities = 87/173 (50%), Positives = 109/173 (63%)
Frame = +1
Query: 16 NSELNEEWETYKTTFGRKYDELTDITRRLIWEQNLKYIQKHNLEYDLGKHTYSLGLNQFA 195
+ LN +W +K T R Y + RR +WE+N+K I+ HN EY GKH +++ +N F
Sbjct: 22 DQSLNAQWYQWKATHRRLYGMNEEGWRRAVWEKNMKMIELHNREYSQGKHGFTMAMNAFG 81
Query: 196 DMTNEEFKAKYLGIMKTKPTLEGSTYMAPENIGVLPASVDWRQKGYVTPVKNQQQCGSCW 375
DMTNEEF+ G K +G + P +P SVDWR+KGYVTPVKNQ QCGSCW
Sbjct: 82 DMTNEEFRQVMNGFQNQKHK-KGKMFQEPL-FAEIPKSVDWREKGYVTPVKNQGQCGSCW 139
Query: 376 SFSATGSLEGQYFRKNNRLISFSEQQLVDCSXXXXXXXXXXXLMDNAFRYITD 534
+FSATG+LEGQ FRK +L+S SEQ LVDCS LMDNAFRY+ D
Sbjct: 140 AFSATGALEGQMFRKTGKLVSLSEQNLVDCSRAQGNEGCNGGLMDNAFRYVKD 192
>sp|Q28944|CATL_PIG Cathepsin L precursor [Contains: Cathepsin L heavy chain; Cathepsin
L light chain]
Length = 334
Score = 172 bits (436), Expect = 5e-43
Identities = 86/174 (49%), Positives = 110/174 (63%)
Frame = +1
Query: 13 VNSELNEEWETYKTTFGRKYDELTDITRRLIWEQNLKYIQKHNLEYDLGKHTYSLGLNQF 192
++ L+ +W +K T GR Y + RR +WE+N+K I+ HN EY GKH +S+ +N F
Sbjct: 21 LDQNLDADWYKWKATHGRLYGMNEEGWRRAVWEKNMKMIELHNQEYSQGKHGFSMAMNAF 80
Query: 193 ADMTNEEFKAKYLGIMKTKPTLEGSTYMAPENIGVLPASVDWRQKGYVTPVKNQQQCGSC 372
DMTNEEF+ G K +G + + V P SVDWR+KGYVT VKNQ QCGSC
Sbjct: 81 GDMTNEEFRQVMNGFQNQKHK-KGKVFHESLVLEV-PKSVDWREKGYVTAVKNQGQCGSC 138
Query: 373 WSFSATGSLEGQYFRKNNRLISFSEQQLVDCSXXXXXXXXXXXLMDNAFRYITD 534
W+FSATG+LEGQ FRK +L+S SEQ LVDCS LMDNAF+Y+ D
Sbjct: 139 WAFSATGALEGQMFRKTGKLVSLSEQNLVDCSRPQGNQGCNGGLMDNAFQYVKD 192
>sp|P07711|CATL_HUMAN Cathepsin L precursor (Major excreted protein) (MEP) [Contains:
Cathepsin L heavy chain; Cathepsin L light chain]
Length = 333
Score = 170 bits (430), Expect = 2e-42
Identities = 85/170 (50%), Positives = 106/170 (62%)
Frame = +1
Query: 25 LNEEWETYKTTFGRKYDELTDITRRLIWEQNLKYIQKHNLEYDLGKHTYSLGLNQFADMT 204
L +W +K R Y + RR +WE+N+K I+ HN EY GKH++++ +N F DMT
Sbjct: 25 LEAQWTKWKAMHNRLYGMNEEGWRRAVWEKNMKMIELHNQEYREGKHSFTMAMNAFGDMT 84
Query: 205 NEEFKAKYLGIMKTKPTLEGSTYMAPENIGVLPASVDWRQKGYVTPVKNQQQCGSCWSFS 384
+EEF+ G KP +G + P P SVDWR+KGYVTPVKNQ QCGSCW+FS
Sbjct: 85 SEEFRQVMNGFQNRKPR-KGKVFQEPLFYEA-PRSVDWREKGYVTPVKNQGQCGSCWAFS 142
Query: 385 ATGSLEGQYFRKNNRLISFSEQQLVDCSXXXXXXXXXXXLMDNAFRYITD 534
ATG+LEGQ FRK RLIS SEQ LVDCS LMD AF+Y+ D
Sbjct: 143 ATGALEGQMFRKTGRLISLSEQNLVDCSGPQGNEGCNGGLMDYAFQYVQD 192
>sp|Q24940|CATLP_FASHE Cathepsin L-like proteinase precursor
Length = 326
Score = 169 bits (429), Expect = 3e-42
Identities = 81/164 (49%), Positives = 105/164 (64%)
Frame = +1
Query: 37 WETYKTTFGRKYDELTDITRRLIWEQNLKYIQKHNLEYDLGKHTYSLGLNQFADMTNEEF 216
W +K + ++Y+ D RR IWE+N+K+IQ+HNL +DLG TY+LGLNQF DMT EEF
Sbjct: 21 WHQWKRMYNKEYNGADDQHRRNIWEKNVKHIQEHNLRHDLGLVTYTLGLNQFTDMTFEEF 80
Query: 217 KAKYLGIMKTKPTLEGSTYMAPENIGVLPASVDWRQKGYVTPVKNQQQCGSCWSFSATGS 396
KAKYL M + N +P +DWR+ GYVT VK+Q CGSCW+FS TG+
Sbjct: 81 KAKYLTEMSRASDILSHGVPYEANNRAVPDKIDWRESGYVTEVKDQGNCGSCWAFSTTGT 140
Query: 397 LEGQYFRKNNRLISFSEQQLVDCSXXXXXXXXXXXLMDNAFRYI 528
+EGQY + ISFSEQQLVDCS LM+NA++Y+
Sbjct: 141 MEGQYMKNERTSISFSEQQLVDCSGPWGNNGCSGGLMENAYQYL 184
>sp|P25975|CATL_BOVIN Cathepsin L precursor [Contains: Cathepsin L heavy chain; Cathepsin
L light chain]
Length = 334
Score = 169 bits (429), Expect = 3e-42
Identities = 86/174 (49%), Positives = 106/174 (60%)
Frame = +1
Query: 13 VNSELNEEWETYKTTFGRKYDELTDITRRLIWEQNLKYIQKHNLEYDLGKHTYSLGLNQF 192
++ L+ W +K T R Y + RR +WE+N K I HN EY GKH + + +N F
Sbjct: 21 LDPNLDAHWHQWKATHRRLYGMNEEEWRRAVWEKNKKIIDLHNQEYSEGKHAFRMAMNAF 80
Query: 193 ADMTNEEFKAKYLGIMKTKPTLEGSTYMAPENIGVLPASVDWRQKGYVTPVKNQQQCGSC 372
DMTNEEF+ G K +G + P + V P SVDW +KGYVTPVKNQ QCGSC
Sbjct: 81 GDMTNEEFRQVMNGFQNQKHK-KGKLFHEPLLVDV-PKSVDWTKKGYVTPVKNQGQCGSC 138
Query: 373 WSFSATGSLEGQYFRKNNRLISFSEQQLVDCSXXXXXXXXXXXLMDNAFRYITD 534
W+FSATG+LEGQ FRK +L+S SEQ LVDCS LMDNAF+YI D
Sbjct: 139 WAFSATGALEGQMFRKTGKLVSLSEQNLVDCSRAQGNQGCNGGLMDNAFQYIKD 192
>sp|O60911|CATL2_HUMAN Cathepsin L2 precursor (Cathepsin V) (Cathepsin U)
Length = 334
Score = 168 bits (426), Expect = 7e-42
Identities = 84/177 (47%), Positives = 113/177 (63%)
Frame = +1
Query: 4 KFSVNSELNEEWETYKTTFGRKYDELTDITRRLIWEQNLKYIQKHNLEYDLGKHTYSLGL 183
KF N L+ +W +K T R Y + RR +WE+N+K I+ HN EY GKH +++ +
Sbjct: 20 KFDQN--LDTKWYQWKATHRRLYGANEEGWRRAVWEKNMKMIELHNGEYSQGKHGFTMAM 77
Query: 184 NQFADMTNEEFKAKYLGIMKTKPTLEGSTYMAPENIGVLPASVDWRQKGYVTPVKNQQQC 363
N F DMTNEEF+ + +G + + +G + P + LP SVDWR+KGYVTPVKNQ+QC
Sbjct: 78 NAFGDMTNEEFR-QMMGCFRNQKFRKGKVFREPLFLD-LPKSVDWRKKGYVTPVKNQKQC 135
Query: 364 GSCWSFSATGSLEGQYFRKNNRLISFSEQQLVDCSXXXXXXXXXXXLMDNAFRYITD 534
GSCW+FSATG+LEGQ FRK +L+S SEQ LVDCS M AF+Y+ +
Sbjct: 136 GSCWAFSATGALEGQMFRKTGKLVSLSEQNLVDCSRPQGNQGCNGGFMARAFQYVKE 192
>sp|P06797|CATL_MOUSE Cathepsin L precursor (Major excreted protein) (MEP) (p39 cysteine
proteinase) [Contains: Cathepsin L heavy chain;
Cathepsin L light chain]
Length = 334
Score = 159 bits (402), Expect = 4e-39
Identities = 83/167 (49%), Positives = 104/167 (62%)
Frame = +1
Query: 34 EWETYKTTFGRKYDELTDITRRLIWEQNLKYIQKHNLEYDLGKHTYSLGLNQFADMTNEE 213
EW +K+T R Y + RR IWE+N++ IQ HN EY G+H +S+ +N F DMTNEE
Sbjct: 28 EWHQWKSTHRRLYGTNEEEWRRAIWEKNMRMIQLHNGEYSNGQHGFSMEMNAFGDMTNEE 87
Query: 214 FKAKYLGIMKTKPTLEGSTYMAPENIGVLPASVDWRQKGYVTPVKNQQQCGSCWSFSATG 393
F+ G K +G + P + + P SVDWR+KG VTPVKNQ QCGSCW+FSA+G
Sbjct: 88 FRQVVNGYRHQKHK-KGRLFQEPLMLKI-PKSVDWREKGCVTPVKNQGQCGSCWAFSASG 145
Query: 394 SLEGQYFRKNNRLISFSEQQLVDCSXXXXXXXXXXXLMDNAFRYITD 534
LEGQ F K +LIS SEQ LVDCS LMD AF+YI +
Sbjct: 146 CLEGQMFLKTGKLISLSEQNLVDCSHAQGNQGCNGGLMDFAFQYIKE 192
>sp|P07154|CATL_RAT Cathepsin L precursor (Major excreted protein) (MEP) (Cyclic
protein 2) (CP-2) [Contains: Cathepsin L heavy chain;
Cathepsin L light chain]
Length = 334
Score = 158 bits (400), Expect = 7e-39
Identities = 81/169 (47%), Positives = 105/169 (62%)
Frame = +1
Query: 28 NEEWETYKTTFGRKYDELTDITRRLIWEQNLKYIQKHNLEYDLGKHTYSLGLNQFADMTN 207
N +W +K+T R Y + RR +WE+N++ IQ HN EY GKH +++ +N F DMTN
Sbjct: 26 NAQWHQWKSTHRRLYGTNEEEWRRAVWEKNMRMIQLHNGEYSNGKHGFTMEMNAFGDMTN 85
Query: 208 EEFKAKYLGIMKTKPTLEGSTYMAPENIGVLPASVDWRQKGYVTPVKNQQQCGSCWSFSA 387
EEF+ G K +G + P + + P +VDWR+KG VTPVKNQ QCGSCW+FSA
Sbjct: 86 EEFRQIVNGYRHQKHK-KGRLFQEPLMLQI-PKTVDWREKGCVTPVKNQGQCGSCWAFSA 143
Query: 388 TGSLEGQYFRKNNRLISFSEQQLVDCSXXXXXXXXXXXLMDNAFRYITD 534
+G LEGQ F K +LIS SEQ LVDCS LMD AF+YI +
Sbjct: 144 SGCLEGQMFLKTGKLISLSEQNLVDCSHDQGNQGCNGGLMDFAFQYIKE 192
>sp|P61277|CATK_MACMU Cathepsin K precursor
sp|P61276|CATK_MACFA Cathepsin K precursor
Length = 329
Score = 157 bits (396), Expect = 2e-38
Identities = 82/170 (48%), Positives = 105/170 (61%), Gaps = 2/170 (1%)
Frame = +1
Query: 25 LNEEWETYKTTFGRKYDELTD-ITRRLIWEQNLKYIQKHNLEYDLGKHTYSLGLNQFADM 201
L+ WE +K T ++Y+ D I+RRLIWE+NLKYI HNLE LG HTY L +N DM
Sbjct: 22 LDTHWELWKKTHRKQYNSKVDEISRRLIWEKNLKYISIHNLEASLGVHTYELAMNHLGDM 81
Query: 202 TNEEFKAKYLGI-MKTKPTLEGSTYMAPENIGVLPASVDWRQKGYVTPVKNQQQCGSCWS 378
TNEE K G+ + + T P+ G P SVD+R+KGYVTPVKNQ QCGSCW+
Sbjct: 82 TNEEVVQKMTGLKVPASHSRSNDTLYIPDWEGRAPDSVDYRKKGYVTPVKNQGQCGSCWA 141
Query: 379 FSATGSLEGQYFRKNNRLISFSEQQLVDCSXXXXXXXXXXXLMDNAFRYI 528
FS+ G+LEGQ +K +L++ S Q LVDC M NAF+Y+
Sbjct: 142 FSSVGALEGQLKKKTGKLLNLSPQNLVDC--VSENDGCGGGYMTNAFQYV 189
>sp|P43236|CATK_RABIT Cathepsin K precursor (OC-2 protein)
Length = 329
Score = 156 bits (395), Expect = 3e-38
Identities = 82/171 (47%), Positives = 109/171 (63%), Gaps = 3/171 (1%)
Frame = +1
Query: 25 LNEEWETYKTTFGRKYDELTD-ITRRLIWEQNLKYIQKHNLEYDLGKHTYSLGLNQFADM 201
L+ +WE +K T+ ++Y+ D I+RRLIWE+NLK+I HNLE LG HTY L +N DM
Sbjct: 22 LDTQWELWKKTYSKQYNSKVDEISRRLIWEKNLKHISIHNLEASLGVHTYELAMNHLGDM 81
Query: 202 TNEEFKAKYLGIMKTKPTLEGS--TYMAPENIGVLPASVDWRQKGYVTPVKNQQQCGSCW 375
T+EE K G+ K P+ S T P+ G P S+D+R+KGYVTPVKNQ QCGSCW
Sbjct: 82 TSEEVVQKMTGL-KVPPSRSHSNDTLYIPDWEGRTPDSIDYRKKGYVTPVKNQGQCGSCW 140
Query: 376 SFSATGSLEGQYFRKNNRLISFSEQQLVDCSXXXXXXXXXXXLMDNAFRYI 528
+FS+ G+LEGQ +K +L++ S Q LVDC M NAF+Y+
Sbjct: 141 AFSSVGALEGQLKKKTGKLLNLSPQNLVDC--VSENYGCGGGYMTNAFQYV 189
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.316 0.132 0.399
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 55,203,218
Number of Sequences: 369166
Number of extensions: 1078787
Number of successful extensions: 3126
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 2905
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 2993
length of database: 68,354,980
effective HSP length: 103
effective length of database: 49,327,275
effective search space used: 3650218350
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)