Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= Dr_sW_025_L04 (769 letters) Database: Non-redundant SwissProt sequences 184,735 sequences; 68,354,980 total letters Score E Sequences producing significant alignments: (bits) Value sp|Q24940|CATLP_FASHE Cathepsin L-like proteinase precursor 211 2e-54 sp|P07154|CATL_RAT Cathepsin L precursor (Major excreted pr... 210 4e-54 sp|O60911|CATL2_HUMAN Cathepsin L2 precursor (Cathepsin V) ... 208 1e-53 sp|P55097|CATK_MOUSE Cathepsin K precursor 206 6e-53 sp|P06797|CATL_MOUSE Cathepsin L precursor (Major excreted ... 206 6e-53 sp|P43236|CATK_RABIT Cathepsin K precursor (OC-2 protein) 205 1e-52 sp|P07711|CATL_HUMAN Cathepsin L precursor (Major excreted ... 205 1e-52 sp|P43235|CATK_HUMAN Cathepsin K precursor (Cathepsin O) (C... 204 2e-52 sp|P61277|CATK_MACMU Cathepsin K precursor >gi|47117667|sp|... 204 2e-52 sp|Q9GL24|CATL_CANFA Cathepsin L precursor [Contains: Cathe... 202 6e-52
>sp|Q24940|CATLP_FASHE Cathepsin L-like proteinase precursor Length = 326 Score = 211 bits (537), Expect = 2e-54 Identities = 98/202 (48%), Positives = 139/202 (68%), Gaps = 2/202 (0%) Frame = +1 Query: 70 NDEWNLYKTRYQKSYLSIVELTRRIIWEENLRYIQHHNLEYDLGKHSYYLGVNEYADLTH 249 +D W+ +K Y K Y + RR IWE+N+++IQ HNL +DLG +Y LG+N++ D+T Sbjct: 18 DDLWHQWKRMYNKEYNGADDQHRRNIWEKNVKHIQEHNLRHDLGLVTYTLGLNQFTDMTF 77 Query: 250 EEFKIKFLGLKPINRNYSRTIFMPPENMDN--YPKSVDWRKKGYVTPVKNQGQCGSCWSF 423 EEFK K+L ++R P +N P +DWR+ GYVT VK+QG CGSCW+F Sbjct: 78 EEFKAKYL--TEMSRASDILSHGVPYEANNRAVPDKIDWRESGYVTEVKDQGNCGSCWAF 135 Query: 424 STTGALEGQHFRKRKQLVSLSEQQLVDCSKDYQNNGCNGGLMDNAFQYIQKYGLESEADY 603 STTG +EGQ+ + + +S SEQQLVDCS + NNGC+GGLM+NA+QY++++GLE+E+ Y Sbjct: 136 STTGTMEGQYMKNERTSISFSEQQLVDCSGPWGNNGCSGGLMENAYQYLKQFGLETESSY 195 Query: 604 PYTAMDGPCKYDSTKVVAHCTG 669 PYTA++G C+Y+ VA TG Sbjct: 196 PYTAVEGQCRYNKQLGVAKVTG 217
>sp|P07154|CATL_RAT Cathepsin L precursor (Major excreted protein) (MEP) (Cyclic protein 2) (CP-2) [Contains: Cathepsin L heavy chain; Cathepsin L light chain] Length = 334 Score = 210 bits (534), Expect = 4e-54 Identities = 109/223 (48%), Positives = 147/223 (65%), Gaps = 1/223 (0%) Frame = +1 Query: 4 VLLLFTILLRSSAFKFQINEELNDEWNLYKTRYQKSYLSIVELTRRIIWEENLRYIQHHN 183 +LLL + L ++ + ++ N +W+ +K+ +++ Y + E RR +WE+N+R IQ HN Sbjct: 4 LLLLAVLCLGTALATPKFDQTFNAQWHQWKSTHRRLYGTNEEEWRRAVWEKNMRMIQLHN 63 Query: 184 LEYDLGKHSYYLGVNEYADLTHEEFKIKFLGLKPINRNYSRTIFMPPENMDNYPKSVDWR 363 EY GKH + + +N + D+T+EEF+ G + R +F P M PK+VDWR Sbjct: 64 GEYSNGKHGFTMEMNAFGDMTNEEFRQIVNGYRHQKHKKGR-LFQEPL-MLQIPKTVDWR 121 Query: 364 KKGYVTPVKNQGQCGSCWSFSTTGALEGQHFRKRKQLVSLSEQQLVDCSKDYQNNGCNGG 543 +KG VTPVKNQGQCGSCW+FS +G LEGQ F K +L+SLSEQ LVDCS D N GCNGG Sbjct: 122 EKGCVTPVKNQGQCGSCWAFSASGCLEGQMFLKTGKLISLSEQNLVDCSHDQGNQGCNGG 181 Query: 544 LMDNAFQYIQKY-GLESEADYPYTAMDGPCKYDSTKVVAHCTG 669 LMD AFQYI++ GL+SE YPY A DG CKY + VA+ TG Sbjct: 182 LMDFAFQYIKENGGLDSEESYPYEAKDGSCKYRAEYAVANDTG 224
Score = 37.4 bits (85), Expect = 0.045 Identities = 21/27 (77%), Positives = 22/27 (81%) Frame = +2 Query: 668 GFVDIKKGNEKDLTKAVATVGPISVAM 748 GFVDI + EK L KAVATVGPISVAM Sbjct: 224 GFVDIPQ-QEKALMKAVATVGPISVAM 249
>sp|O60911|CATL2_HUMAN Cathepsin L2 precursor (Cathepsin V) (Cathepsin U) Length = 334 Score = 208 bits (530), Expect = 1e-53 Identities = 110/223 (49%), Positives = 146/223 (65%), Gaps = 1/223 (0%) Frame = +1 Query: 4 VLLLFTILLRSSAFKFQINEELNDEWNLYKTRYQKSYLSIVELTRRIIWEENLRYIQHHN 183 VL F + + S+ KF N L+ +W +K +++ Y + E RR +WE+N++ I+ HN Sbjct: 6 VLAAFCLGIASAVPKFDQN--LDTKWYQWKATHRRLYGANEEGWRRAVWEKNMKMIELHN 63 Query: 184 LEYDLGKHSYYLGVNEYADLTHEEFKIKFLGLKPINRNYSRTIFMPPENMDNYPKSVDWR 363 EY GKH + + +N + D+T+EEF+ + +G + +F P +D PKSVDWR Sbjct: 64 GEYSQGKHGFTMAMNAFGDMTNEEFR-QMMGCFRNQKFRKGKVFREPLFLD-LPKSVDWR 121 Query: 364 KKGYVTPVKNQGQCGSCWSFSTTGALEGQHFRKRKQLVSLSEQQLVDCSKDYQNNGCNGG 543 KKGYVTPVKNQ QCGSCW+FS TGALEGQ FRK +LVSLSEQ LVDCS+ N GCNGG Sbjct: 122 KKGYVTPVKNQKQCGSCWAFSATGALEGQMFRKTGKLVSLSEQNLVDCSRPQGNQGCNGG 181 Query: 544 LMDNAFQYIQKY-GLESEADYPYTAMDGPCKYDSTKVVAHCTG 669 M AFQY+++ GL+SE YPY A+D CKY VA+ TG Sbjct: 182 FMARAFQYVKENGGLDSEESYPYVAVDEICKYRPENSVANDTG 224
Score = 38.1 bits (87), Expect = 0.026 Identities = 19/27 (70%), Positives = 20/27 (74%) Frame = +2 Query: 668 GFVDIKKGNEKDLTKAVATVGPISVAM 748 GF + G EK L KAVATVGPISVAM Sbjct: 224 GFTVVAPGKEKALMKAVATVGPISVAM 250
>sp|P55097|CATK_MOUSE Cathepsin K precursor Length = 329 Score = 206 bits (524), Expect = 6e-53 Identities = 108/219 (49%), Positives = 140/219 (63%), Gaps = 3/219 (1%) Frame = +1 Query: 22 ILLRSSAFKFQINEELNDEWNLYKTRYQKSYLSIV-ELTRRIIWEENLRYIQHHNLEYDL 198 +LL +F E L+ +W L+K +QK Y S V E++RR+IWE+NL+ I HNLE L Sbjct: 7 LLLPMVSFALSPEEMLDTQWELWKKTHQKQYNSKVDEISRRLIWEKNLKQISAHNLEASL 66 Query: 199 GKHSYYLGVNEYADLTHEEFKIKFLGLK-PINRNYSRTIFMPPENMDNYPKSVDWRKKGY 375 G H+Y L +N D+T EE K GL+ P +R+YS PE P S+D+RKKGY Sbjct: 67 GVHTYELAMNHLGDMTSEEVVQKMTGLRIPPSRSYSNDTLYTPEWEGRVPDSIDYRKKGY 126 Query: 376 VTPVKNQGQCGSCWSFSTTGALEGQHFRKRKQLVSLSEQQLVDCSKDYQNNGCNGGLMDN 555 VTPVKNQGQCGSCW+FS+ GALEGQ +K +L++LS Q LVDC +N GC GG M Sbjct: 127 VTPVKNQGQCGSCWAFSSAGALEGQLKKKTGKLLALSPQNLVDCVT--ENYGCGGGYMTT 184 Query: 556 AFQYIQKY-GLESEADYPYTAMDGPCKYDSTKVVAHCTG 669 AFQY+Q+ G++SE YPY D C Y++T A C G Sbjct: 185 AFQYVQQNGGIDSEDAYPYVGQDESCMYNATAKAAKCRG 223
Score = 33.9 bits (76), Expect = 0.50 Identities = 16/27 (59%), Positives = 21/27 (77%) Frame = +2 Query: 668 GFVDIKKGNEKDLTKAVATVGPISVAM 748 G+ +I GNEK L +AVA VGPISV++ Sbjct: 223 GYREIPVGNEKALKRAVARVGPISVSI 249
>sp|P06797|CATL_MOUSE Cathepsin L precursor (Major excreted protein) (MEP) (p39 cysteine proteinase) [Contains: Cathepsin L heavy chain; Cathepsin L light chain] Length = 334 Score = 206 bits (524), Expect = 6e-53 Identities = 109/223 (48%), Positives = 146/223 (65%), Gaps = 1/223 (0%) Frame = +1 Query: 4 VLLLFTILLRSSAFKFQINEELNDEWNLYKTRYQKSYLSIVELTRRIIWEENLRYIQHHN 183 +LLL + L ++ + ++ + EW+ +K+ +++ Y + E RR IWE+N+R IQ HN Sbjct: 4 LLLLAVLCLGTALATPKFDQTFSAEWHQWKSTHRRLYGTNEEEWRRAIWEKNMRMIQLHN 63 Query: 184 LEYDLGKHSYYLGVNEYADLTHEEFKIKFLGLKPINRNYSRTIFMPPENMDNYPKSVDWR 363 EY G+H + + +N + D+T+EEF+ G + R +F P M PKSVDWR Sbjct: 64 GEYSNGQHGFSMEMNAFGDMTNEEFRQVVNGYRHQKHKKGR-LFQEPL-MLKIPKSVDWR 121 Query: 364 KKGYVTPVKNQGQCGSCWSFSTTGALEGQHFRKRKQLVSLSEQQLVDCSKDYQNNGCNGG 543 +KG VTPVKNQGQCGSCW+FS +G LEGQ F K +L+SLSEQ LVDCS N GCNGG Sbjct: 122 EKGCVTPVKNQGQCGSCWAFSASGCLEGQMFLKTGKLISLSEQNLVDCSHAQGNQGCNGG 181 Query: 544 LMDNAFQYIQKY-GLESEADYPYTAMDGPCKYDSTKVVAHCTG 669 LMD AFQYI++ GL+SE YPY A DG CKY + VA+ TG Sbjct: 182 LMDFAFQYIKENGGLDSEESYPYEAKDGSCKYRAEFAVANDTG 224
Score = 37.4 bits (85), Expect = 0.045 Identities = 21/27 (77%), Positives = 22/27 (81%) Frame = +2 Query: 668 GFVDIKKGNEKDLTKAVATVGPISVAM 748 GFVDI + EK L KAVATVGPISVAM Sbjct: 224 GFVDIPQ-QEKALMKAVATVGPISVAM 249
>sp|P43236|CATK_RABIT Cathepsin K precursor (OC-2 protein) Length = 329 Score = 205 bits (522), Expect = 1e-52 Identities = 109/222 (49%), Positives = 141/222 (63%), Gaps = 3/222 (1%) Frame = +1 Query: 13 LFTILLRSSAFKFQINEELNDEWNLYKTRYQKSYLSIV-ELTRRIIWEENLRYIQHHNLE 189 L +LL +F E L+ +W L+K Y K Y S V E++RR+IWE+NL++I HNLE Sbjct: 4 LKVLLLPVVSFALHPEEILDTQWELWKKTYSKQYNSKVDEISRRLIWEKNLKHISIHNLE 63 Query: 190 YDLGKHSYYLGVNEYADLTHEEFKIKFLGLK-PINRNYSRTIFMPPENMDNYPKSVDWRK 366 LG H+Y L +N D+T EE K GLK P +R++S P+ P S+D+RK Sbjct: 64 ASLGVHTYELAMNHLGDMTSEEVVQKMTGLKVPPSRSHSNDTLYIPDWEGRTPDSIDYRK 123 Query: 367 KGYVTPVKNQGQCGSCWSFSTTGALEGQHFRKRKQLVSLSEQQLVDCSKDYQNNGCNGGL 546 KGYVTPVKNQGQCGSCW+FS+ GALEGQ +K +L++LS Q LVDC +N GC GG Sbjct: 124 KGYVTPVKNQGQCGSCWAFSSVGALEGQLKKKTGKLLNLSPQNLVDCVS--ENYGCGGGY 181 Query: 547 MDNAFQYIQK-YGLESEADYPYTAMDGPCKYDSTKVVAHCTG 669 M NAFQY+Q+ G++SE YPY D C Y+ T A C G Sbjct: 182 MTNAFQYVQRNRGIDSEDAYPYVGQDESCMYNPTGKAAKCRG 223
Score = 35.8 bits (81), Expect = 0.13 Identities = 16/27 (59%), Positives = 22/27 (81%) Frame = +2 Query: 668 GFVDIKKGNEKDLTKAVATVGPISVAM 748 G+ +I +GNEK L +AVA VGP+SVA+ Sbjct: 223 GYREIPEGNEKALKRAVARVGPVSVAI 249
>sp|P07711|CATL_HUMAN Cathepsin L precursor (Major excreted protein) (MEP) [Contains: Cathepsin L heavy chain; Cathepsin L light chain] Length = 333 Score = 205 bits (521), Expect = 1e-52 Identities = 107/223 (47%), Positives = 139/223 (62%), Gaps = 1/223 (0%) Frame = +1 Query: 4 VLLLFTILLRSSAFKFQINEELNDEWNLYKTRYQKSYLSIVELTRRIIWEENLRYIQHHN 183 +L F + + S+ F + L +W +K + + Y E RR +WE+N++ I+ HN Sbjct: 6 ILAAFCLGIASATLTF--DHSLEAQWTKWKAMHNRLYGMNEEGWRRAVWEKNMKMIELHN 63 Query: 184 LEYDLGKHSYYLGVNEYADLTHEEFKIKFLGLKPINRNYSRTIFMPPENMDNYPKSVDWR 363 EY GKHS+ + +N + D+T EEF+ G + NR + P+SVDWR Sbjct: 64 QEYREGKHSFTMAMNAFGDMTSEEFRQVMNGFQ--NRKPRKGKVFQEPLFYEAPRSVDWR 121 Query: 364 KKGYVTPVKNQGQCGSCWSFSTTGALEGQHFRKRKQLVSLSEQQLVDCSKDYQNNGCNGG 543 +KGYVTPVKNQGQCGSCW+FS TGALEGQ FRK +L+SLSEQ LVDCS N GCNGG Sbjct: 122 EKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGRLISLSEQNLVDCSGPQGNEGCNGG 181 Query: 544 LMDNAFQYIQ-KYGLESEADYPYTAMDGPCKYDSTKVVAHCTG 669 LMD AFQY+Q GL+SE YPY A + CKY+ VA+ TG Sbjct: 182 LMDYAFQYVQDNGGLDSEESYPYEATEESCKYNPKYSVANDTG 224
Score = 37.4 bits (85), Expect = 0.045 Identities = 21/27 (77%), Positives = 22/27 (81%) Frame = +2 Query: 668 GFVDIKKGNEKDLTKAVATVGPISVAM 748 GFVDI K EK L KAVATVGPISVA+ Sbjct: 224 GFVDIPK-QEKALMKAVATVGPISVAI 249
>sp|P43235|CATK_HUMAN Cathepsin K precursor (Cathepsin O) (Cathepsin X) (Cathepsin O2) Length = 329 Score = 204 bits (519), Expect = 2e-52 Identities = 109/222 (49%), Positives = 141/222 (63%), Gaps = 3/222 (1%) Frame = +1 Query: 13 LFTILLRSSAFKFQINEELNDEWNLYKTRYQKSYLSIV-ELTRRIIWEENLRYIQHHNLE 189 L +LL +F E L+ W L+K ++K Y + V E++RR+IWE+NL+YI HNLE Sbjct: 4 LKVLLLPVVSFALYPEEILDTHWELWKKTHRKQYNNKVDEISRRLIWEKNLKYISIHNLE 63 Query: 190 YDLGKHSYYLGVNEYADLTHEEFKIKFLGLK-PINRNYSRTIFMPPENMDNYPKSVDWRK 366 LG H+Y L +N D+T EE K GLK P++ + S PE P SVD+RK Sbjct: 64 ASLGVHTYELAMNHLGDMTSEEVVQKMTGLKVPLSHSRSNDTLYIPEWEGRAPDSVDYRK 123 Query: 367 KGYVTPVKNQGQCGSCWSFSTTGALEGQHFRKRKQLVSLSEQQLVDCSKDYQNNGCNGGL 546 KGYVTPVKNQGQCGSCW+FS+ GALEGQ +K +L++LS Q LVDC +N+GC GG Sbjct: 124 KGYVTPVKNQGQCGSCWAFSSVGALEGQLKKKTGKLLNLSPQNLVDCVS--ENDGCGGGY 181 Query: 547 MDNAFQYIQK-YGLESEADYPYTAMDGPCKYDSTKVVAHCTG 669 M NAFQY+QK G++SE YPY + C Y+ T A C G Sbjct: 182 MTNAFQYVQKNRGIDSEDAYPYVGQEESCMYNPTGKAAKCRG 223
Score = 35.8 bits (81), Expect = 0.13 Identities = 16/27 (59%), Positives = 22/27 (81%) Frame = +2 Query: 668 GFVDIKKGNEKDLTKAVATVGPISVAM 748 G+ +I +GNEK L +AVA VGP+SVA+ Sbjct: 223 GYREIPEGNEKALKRAVARVGPVSVAI 249
>sp|P61277|CATK_MACMU Cathepsin K precursor sp|P61276|CATK_MACFA Cathepsin K precursor Length = 329 Score = 204 bits (519), Expect = 2e-52 Identities = 109/222 (49%), Positives = 141/222 (63%), Gaps = 3/222 (1%) Frame = +1 Query: 13 LFTILLRSSAFKFQINEELNDEWNLYKTRYQKSYLSIV-ELTRRIIWEENLRYIQHHNLE 189 L +LL +F E L+ W L+K ++K Y S V E++RR+IWE+NL+YI HNLE Sbjct: 4 LKVLLLPVMSFALYPEEILDTHWELWKKTHRKQYNSKVDEISRRLIWEKNLKYISIHNLE 63 Query: 190 YDLGKHSYYLGVNEYADLTHEEFKIKFLGLK-PINRNYSRTIFMPPENMDNYPKSVDWRK 366 LG H+Y L +N D+T+EE K GLK P + + S P+ P SVD+RK Sbjct: 64 ASLGVHTYELAMNHLGDMTNEEVVQKMTGLKVPASHSRSNDTLYIPDWEGRAPDSVDYRK 123 Query: 367 KGYVTPVKNQGQCGSCWSFSTTGALEGQHFRKRKQLVSLSEQQLVDCSKDYQNNGCNGGL 546 KGYVTPVKNQGQCGSCW+FS+ GALEGQ +K +L++LS Q LVDC +N+GC GG Sbjct: 124 KGYVTPVKNQGQCGSCWAFSSVGALEGQLKKKTGKLLNLSPQNLVDCVS--ENDGCGGGY 181 Query: 547 MDNAFQYIQK-YGLESEADYPYTAMDGPCKYDSTKVVAHCTG 669 M NAFQY+QK G++SE YPY + C Y+ T A C G Sbjct: 182 MTNAFQYVQKNRGIDSEDAYPYVGQEESCMYNPTGKAAKCRG 223
Score = 35.8 bits (81), Expect = 0.13 Identities = 16/27 (59%), Positives = 22/27 (81%) Frame = +2 Query: 668 GFVDIKKGNEKDLTKAVATVGPISVAM 748 G+ +I +GNEK L +AVA VGP+SVA+ Sbjct: 223 GYREIPEGNEKALKRAVARVGPVSVAI 249
>sp|Q9GL24|CATL_CANFA Cathepsin L precursor [Contains: Cathepsin L heavy chain; Cathepsin L light chain] Length = 333 Score = 202 bits (515), Expect = 6e-52 Identities = 105/216 (48%), Positives = 139/216 (64%), Gaps = 2/216 (0%) Frame = +1 Query: 28 LRSSAFKFQINEELNDEWNLYKTRYQKSYLSIVELTRRIIWEENLRYIQHHNLEYDLGKH 207 + S+A KF ++ LN +W +K +++ Y E RR +WE+N++ I+ HN EY GKH Sbjct: 14 IASAAPKF--DQSLNAQWYQWKATHRRLYGMNEEGWRRAVWEKNMKMIELHNREYSQGKH 71 Query: 208 SYYLGVNEYADLTHEEFKIKFLGLKPINRNYSRTIFMPPENMDNYPKSVDWRKKGYVTPV 387 + + +N + D+T+EEF+ G + N+ + + PKSVDWR+KGYVTPV Sbjct: 72 GFTMAMNAFGDMTNEEFRQVMNGFQ--NQKHKKGKMFQEPLFAEIPKSVDWREKGYVTPV 129 Query: 388 KNQGQCGSCWSFSTTGALEGQHFRKRKQLVSLSEQQLVDCSKDYQNNGCNGGLMDNAFQY 567 KNQGQCGSCW+FS TGALEGQ FRK +LVSLSEQ LVDCS+ N GCNGGLMDNAF+Y Sbjct: 130 KNQGQCGSCWAFSATGALEGQMFRKTGKLVSLSEQNLVDCSRAQGNEGCNGGLMDNAFRY 189 Query: 568 IQ-KYGLESEADYPYTAMD-GPCKYDSTKVVAHCTG 669 ++ GL+SE YPY D C Y A+ TG Sbjct: 190 VKDNGGLDSEESYPYLGRDTETCNYKPECSAANDTG 225
Score = 33.9 bits (76), Expect = 0.50 Identities = 18/27 (66%), Positives = 22/27 (81%) Frame = +2 Query: 668 GFVDIKKGNEKDLTKAVATVGPISVAM 748 GFVD+ + EK L KAVAT+GPISVA+ Sbjct: 225 GFVDLPQ-REKALMKAVATLGPISVAI 250
Database: Non-redundant SwissProt sequences Posted date: Dec 6, 2005 7:40 AM Number of letters in database: 68,354,980 Number of sequences in database: 184,735 Database: swissprot.01 Posted date: Dec 6, 2005 8:18 AM Number of letters in database: 66,202,850 Number of sequences in database: 184,431 Lambda K H 0.318 0.134 0.401 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 86,234,980 Number of Sequences: 369166 Number of extensions: 1787258 Number of successful extensions: 5324 Number of sequences better than 10.0: 10 Number of HSP's better than 10.0 without gapping: 4764 Number of HSP's successfully gapped in prelim test: 0 Number of HSP's that attempted gapping in prelim test: 0 Number of HSP's gapped (non-prelim): 4976 length of database: 68,354,980 effective HSP length: 108 effective length of database: 48,403,600 effective search space used: 7115329200 frameshift window, decay const: 40, 0.1 T: 12 A: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.7 bits)