Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_025_J21
(820 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q24940|CATLP_FASHE Cathepsin L-like proteinase precursor 168 2e-41
sp|O60911|CATL2_HUMAN Cathepsin L2 precursor (Cathepsin V) ... 162 8e-40
sp|Q9R014|CATJ_MOUSE Cathepsin J precursor (Cathepsin P) (C... 157 4e-38
sp|Q9GL24|CATL_CANFA Cathepsin L precursor [Contains: Cathe... 154 4e-37
sp|Q28944|CATL_PIG Cathepsin L precursor [Contains: Catheps... 153 6e-37
sp|Q9JIA9|CATR_MOUSE Cathepsin R precursor 152 8e-37
sp|P07711|CATL_HUMAN Cathepsin L precursor (Major excreted ... 151 2e-36
sp|Q26636|CATL_SARPE Cathepsin L precursor [Contains: Cathe... 149 7e-36
sp|Q9JL96|CATM_MOUSE Cathepsin M precursor 149 7e-36
sp|Q95029|CATL_DROME Cathepsin L precursor (Cysteine protei... 149 1e-35
>sp|Q24940|CATLP_FASHE Cathepsin L-like proteinase precursor
Length = 326
Score = 168 bits (425), Expect = 2e-41
Identities = 92/257 (35%), Positives = 139/257 (54%), Gaps = 6/257 (2%)
Frame = +3
Query: 57 WEDYKTIFNKKYSDETDLIRRNIWEENLKFIKQHNLQFDLGKTKFSVGLNEFSDMNQKEF 236
W +K ++NK+Y+ D RRNIWE+N+K I++HNL+ DLG +++GLN+F+DM +EF
Sbjct: 21 WHQWKRMYNKEYNGADDQHRRNIWEKNVKHIQEHNLRHDLGLVTYTLGLNQFTDMTFEEF 80
Query: 237 QSNILSVXXXXXXXXXXXXXXXXXXLSRNDFITT------PNNIKLPDSWDWREKGAVSP 398
++ L+ +SR I + NN +PD DWRE G V+
Sbjct: 81 KAKYLT------------------EMSRASDILSHGVPYEANNRAVPDKIDWRESGYVTE 122
Query: 399 VGNQRNNCCGYAFAAAGALEGQNFNLTKTLEILSKQQIIDCSIYYGNSNCYSGCILSKAY 578
V +Q N +AF+ G +EGQ +T S+QQ++DCS +GN+ C SG ++ AY
Sbjct: 123 VKDQGNCGSCWAFSTTGTMEGQYMKNERTSISFSEQQLVDCSGPWGNNGC-SGGLMENAY 181
Query: 579 AYLADYGSELDEDYPFVGYNSNCKYDKSLATVKPYGFKYVSRGKEADLMNAVYNIGPISA 758
YL +G E + YP+ C+Y+K L K G+ V G E +L N V P +
Sbjct: 182 QYLKQFGLETESSYPYTAVEGQCRYNKQLGVAKVTGYYTVHSGSEVELKNLVGARRPAAV 241
Query: 759 AIDASPNTFKQYKTGIY 809
A+D + F Y++GIY
Sbjct: 242 AVDVE-SDFMMYRSGIY 257
>sp|O60911|CATL2_HUMAN Cathepsin L2 precursor (Cathepsin V) (Cathepsin U)
Length = 334
Score = 162 bits (411), Expect = 8e-40
Identities = 91/259 (35%), Positives = 137/259 (52%), Gaps = 1/259 (0%)
Frame = +3
Query: 36 NSQLNKDWEDYKTIFNKKYSDETDLIRRNIWEENLKFIKQHNLQFDLGKTKFSVGLNEFS 215
+ L+ W +K + Y + RR +WE+N+K I+ HN ++ GK F++ +N F
Sbjct: 22 DQNLDTKWYQWKATHRRLYGANEEGWRRAVWEKNMKMIELHNGEYSQGKHGFTMAMNAFG 81
Query: 216 DMNQKEFQSNILSVXXXXXXXXXXXXXXXXXXLSRNDFITTPNNIKLPDSWDWREKGAVS 395
DM +EF+ + + P + LP S DWR+KG V+
Sbjct: 82 DMTNEEFRQMM--------------GCFRNQKFRKGKVFREPLFLDLPKSVDWRKKGYVT 127
Query: 396 PVGNQRNNCCGYAFAAAGALEGQNFNLTKTLEILSKQQIIDCSIYYGNSNCYSGCILSKA 575
PV NQ+ +AF+A GALEGQ F T L LS+Q ++DCS GN C +G +++A
Sbjct: 128 PVKNQKQCGSCWAFSATGALEGQMFRKTGKLVSLSEQNLVDCSRPQGNQGC-NGGFMARA 186
Query: 576 YAYLADYGS-ELDEDYPFVGYNSNCKYDKSLATVKPYGFKYVSRGKEADLMNAVYNIGPI 752
+ Y+ + G + +E YP+V + CKY + GF V+ GKE LM AV +GPI
Sbjct: 187 FQYVKENGGLDSEESYPYVAVDEICKYRPENSVANDTGFTVVAPGKEKALMKAVATVGPI 246
Query: 753 SAAIDASPNTFKQYKTGIY 809
S A+DA ++F+ YK+GIY
Sbjct: 247 SVAMDAGHSSFQFYKSGIY 265
>sp|Q9R014|CATJ_MOUSE Cathepsin J precursor (Cathepsin P) (Catlrp-p)
Length = 333
Score = 157 bits (396), Expect = 4e-38
Identities = 97/261 (37%), Positives = 140/261 (53%), Gaps = 5/261 (1%)
Frame = +3
Query: 42 QLNKDWEDYKTIFNKKYSDETDLIRRNIWEENLKFIKQHNLQFDLGKTKFSVGLNEFSDM 221
+L+ +W+D+KT + K YS E + +RR +WEEN++ IK HN + LGK F++ +N+F D
Sbjct: 24 KLDAEWKDWKTKYAKSYSPE-EALRRAVWEENMRMIKLHNKENSLGKNNFTMKMNKFGDQ 82
Query: 222 NQKEFQSNILSVXXXXXXXXXXXXXXXXXXLSRNDFITTPN-----NIKLPDSWDWREKG 386
+EF+ +I ++ +T P+ +I LPD DWRE+G
Sbjct: 83 TSEEFRKSIDNIPIPAA-------------------MTDPHAQNHVSIGLPDYKDWREEG 123
Query: 387 AVSPVGNQRNNCCGYAFAAAGALEGQNFNLTKTLEILSKQQIIDCSIYYGNSNCYSGCIL 566
V+PV NQ +AFAAAGA+EGQ F T L LS Q ++DCS GN C SG
Sbjct: 124 YVTPVRNQGKCGSCWAFAAAGAIEGQMFWKTGNLTPLSVQNLLDCSKTVGNKGCQSGTAH 183
Query: 567 SKAYAYLADYGSELDEDYPFVGYNSNCKYDKSLATVKPYGFKYVSRGKEADLMNAVYNIG 746
L + G E + YP+ G + C+Y A+ + + E L AV +IG
Sbjct: 184 QAFEYVLKNKGLEAEATYPYEGKDGPCRYRSENASANITDYVNLP-PNELYLWVAVASIG 242
Query: 747 PISAAIDASPNTFKQYKTGIY 809
P+SAAIDAS ++F+ Y GIY
Sbjct: 243 PVSAAIDASHDSFRFYNGGIY 263
>sp|Q9GL24|CATL_CANFA Cathepsin L precursor [Contains: Cathepsin L heavy chain; Cathepsin
L light chain]
Length = 333
Score = 154 bits (388), Expect = 4e-37
Identities = 91/262 (34%), Positives = 135/262 (51%), Gaps = 2/262 (0%)
Frame = +3
Query: 36 NSQLNKDWEDYKTIFNKKYSDETDLIRRNIWEENLKFIKQHNLQFDLGKTKFSVGLNEFS 215
+ LN W +K + Y + RR +WE+N+K I+ HN ++ GK F++ +N F
Sbjct: 22 DQSLNAQWYQWKATHRRLYGMNEEGWRRAVWEKNMKMIELHNREYSQGKHGFTMAMNAFG 81
Query: 216 DMNQKEFQSNILSVXXXXXXXXXXXXXXXXXXLSRNDFITTPNNIKLPDSWDWREKGAVS 395
DM +EF+ + + P ++P S DWREKG V+
Sbjct: 82 DMTNEEFRQVMNGFQNQKH--------------KKGKMFQEPLFAEIPKSVDWREKGYVT 127
Query: 396 PVGNQRNNCCGYAFAAAGALEGQNFNLTKTLEILSKQQIIDCSIYYGNSNCYSGCILSKA 575
PV NQ +AF+A GALEGQ F T L LS+Q ++DCS GN C +G ++ A
Sbjct: 128 PVKNQGQCGSCWAFSATGALEGQMFRKTGKLVSLSEQNLVDCSRAQGNEGC-NGGLMDNA 186
Query: 576 YAYLADYGS-ELDEDYPFVGYNS-NCKYDKSLATVKPYGFKYVSRGKEADLMNAVYNIGP 749
+ Y+ D G + +E YP++G ++ C Y + GF + + +E LM AV +GP
Sbjct: 187 FRYVKDNGGLDSEESYPYLGRDTETCNYKPECSAANDTGFVDLPQ-REKALMKAVATLGP 245
Query: 750 ISAAIDASPNTFKQYKTGIYDD 815
IS AIDA +F+ YK+GIY D
Sbjct: 246 ISVAIDAGHQSFQFYKSGIYFD 267
>sp|Q28944|CATL_PIG Cathepsin L precursor [Contains: Cathepsin L heavy chain; Cathepsin
L light chain]
Length = 334
Score = 153 bits (386), Expect = 6e-37
Identities = 94/270 (34%), Positives = 140/270 (51%), Gaps = 2/270 (0%)
Frame = +3
Query: 12 ASRIDSNVNSQLNKDWEDYKTIFNKKYSDETDLIRRNIWEENLKFIKQHNLQFDLGKTKF 191
A ++D N L+ DW +K + Y + RR +WE+N+K I+ HN ++ GK F
Sbjct: 18 APKLDQN----LDADWYKWKATHGRLYGMNEEGWRRAVWEKNMKMIELHNQEYSQGKHGF 73
Query: 192 SVGLNEFSDMNQKEFQSNILSVXXXXXXXXXXXXXXXXXXLSRNDFITTPNNIKLPDSWD 371
S+ +N F DM +EF+ + + +++P S D
Sbjct: 74 SMAMNAFGDMTNEEFRQVMNGFQNQKH--------------KKGKVFHESLVLEVPKSVD 119
Query: 372 WREKGAVSPVGNQRNNCCGYAFAAAGALEGQNFNLTKTLEILSKQQIIDCSIYYGNSNCY 551
WREKG V+ V NQ +AF+A GALEGQ F T L LS+Q ++DCS GN C
Sbjct: 120 WREKGYVTAVKNQGQCGSCWAFSATGALEGQMFRKTGKLVSLSEQNLVDCSRPQGNQGC- 178
Query: 552 SGCILSKAYAYLADYGS-ELDEDYPFVGYNSN-CKYDKSLATVKPYGFKYVSRGKEADLM 725
+G ++ A+ Y+ D G + +E YP++G +N C Y + GF + + +E LM
Sbjct: 179 NGGLMDNAFQYVKDNGGLDTEESYPYLGRETNSCTYKPECSAANDTGFVDIPQ-REKALM 237
Query: 726 NAVYNIGPISAAIDASPNTFKQYKTGIYDD 815
AV +GPIS AIDA ++F+ YK+GIY D
Sbjct: 238 KAVATVGPISVAIDAGHSSFQFYKSGIYYD 267
>sp|Q9JIA9|CATR_MOUSE Cathepsin R precursor
Length = 334
Score = 152 bits (385), Expect = 8e-37
Identities = 89/261 (34%), Positives = 135/261 (51%)
Frame = +3
Query: 33 VNSQLNKDWEDYKTIFNKKYSDETDLIRRNIWEENLKFIKQHNLQFDLGKTKFSVGLNEF 212
++S L+ +W+D+K +NK YS + + ++R +WEE LK IK HN + LGK F++ +NEF
Sbjct: 21 LDSSLDAEWQDWKIKYNKSYSLKEEKLKRVVWEEKLKMIKLHNRENSLGKNGFTMKMNEF 80
Query: 213 SDMNQKEFQSNILSVXXXXXXXXXXXXXXXXXXLSRNDFITTPNNIKLPDSWDWREKGAV 392
D +EF+ ++ + + LP DWR+KG V
Sbjct: 81 GDQTDEEFRKMMIEISVWTHREGKSIMKREAGSI-------------LPKFVDWRKKGYV 127
Query: 393 SPVGNQRNNCCGYAFAAAGALEGQNFNLTKTLEILSKQQIIDCSIYYGNSNCYSGCILSK 572
+PV Q + +AFA GA+E Q T L LS Q ++DCS GN+ C G +
Sbjct: 128 TPVRRQGDCDACWAFAVTGAIEAQAIWQTGKLTPLSVQNLVDCSKPQGNNGCLGGDTYNA 187
Query: 573 AYAYLADYGSELDEDYPFVGYNSNCKYDKSLATVKPYGFKYVSRGKEADLMNAVYNIGPI 752
L + G E + YP+ G + C+Y+ + + GF + + ++ LM AV IGPI
Sbjct: 188 FQYVLHNGGLESEATYPYEGKDGPCRYNPKNSKAEITGFVSLPQSEDI-LMAAVATIGPI 246
Query: 753 SAAIDASPNTFKQYKTGIYDD 815
+A IDAS +FK YK GIY +
Sbjct: 247 TAGIDASHESFKNYKGGIYHE 267
>sp|P07711|CATL_HUMAN Cathepsin L precursor (Major excreted protein) (MEP) [Contains:
Cathepsin L heavy chain; Cathepsin L light chain]
Length = 333
Score = 151 bits (382), Expect = 2e-36
Identities = 90/256 (35%), Positives = 131/256 (51%), Gaps = 1/256 (0%)
Frame = +3
Query: 45 LNKDWEDYKTIFNKKYSDETDLIRRNIWEENLKFIKQHNLQFDLGKTKFSVGLNEFSDMN 224
L W +K + N+ Y + RR +WE+N+K I+ HN ++ GK F++ +N F DM
Sbjct: 25 LEAQWTKWKAMHNRLYGMNEEGWRRAVWEKNMKMIELHNQEYREGKHSFTMAMNAFGDMT 84
Query: 225 QKEFQSNILSVXXXXXXXXXXXXXXXXXXLSRNDFITTPNNIKLPDSWDWREKGAVSPVG 404
+EF+ + + P + P S DWREKG V+PV
Sbjct: 85 SEEFRQVMNGFQNRKPR--------------KGKVFQEPLFYEAPRSVDWREKGYVTPVK 130
Query: 405 NQRNNCCGYAFAAAGALEGQNFNLTKTLEILSKQQIIDCSIYYGNSNCYSGCILSKAYAY 584
NQ +AF+A GALEGQ F T L LS+Q ++DCS GN C +G ++ A+ Y
Sbjct: 131 NQGQCGSCWAFSATGALEGQMFRKTGRLISLSEQNLVDCSGPQGNEGC-NGGLMDYAFQY 189
Query: 585 LADYGS-ELDEDYPFVGYNSNCKYDKSLATVKPYGFKYVSRGKEADLMNAVYNIGPISAA 761
+ D G + +E YP+ +CKY+ + GF + + ++A LM AV +GPIS A
Sbjct: 190 VQDNGGLDSEESYPYEATEESCKYNPKYSVANDTGFVDIPKQEKA-LMKAVATVGPISVA 248
Query: 762 IDASPNTFKQYKTGIY 809
IDA +F YK GIY
Sbjct: 249 IDAGHESFLFYKEGIY 264
>sp|Q26636|CATL_SARPE Cathepsin L precursor [Contains: Cathepsin L heavy chain; Cathepsin
L light chain]
Length = 339
Score = 149 bits (377), Expect = 7e-36
Identities = 85/259 (32%), Positives = 138/259 (53%), Gaps = 2/259 (0%)
Frame = +3
Query: 45 LNKDWEDYKTIFNKKYSDETD-LIRRNIWEENLKFIKQHNLQFDLGKTKFSVGLNEFSDM 221
+ ++W YK K Y++E + R I+ EN I +HN F GK + +GLN+++DM
Sbjct: 24 IKEEWHTYKLQHRKNYANEVEERFRMKIFNENRHKIAKHNQLFAQGKVSYKLGLNKYADM 83
Query: 222 NQKEFQSNILSVXXXXXXXXXXXXXXXXXXLSRNDFITTPNNIKLPDSWDWREKGAVSPV 401
EF+ + L +I P ++ +P S DWRE GAV+ V
Sbjct: 84 LHHEFKETM-----NGYNHTLRQLMRERTGLVGATYI-PPAHVTVPKSVDWREHGAVTGV 137
Query: 402 GNQRNNCCGYAFAAAGALEGQNFNLTKTLEILSKQQIIDCSIYYGNSNCYSGCILSKAYA 581
+Q + +AF++ GALEGQ+F L LS+Q ++DCS YGN+ C +G ++ A+
Sbjct: 138 KDQGHCGSCWAFSSTGALEGQHFRKAGVLVSLSEQNLVDCSTKYGNNGC-NGGLMDNAFR 196
Query: 582 YLADYGS-ELDEDYPFVGYNSNCKYDKSLATVKPYGFKYVSRGKEADLMNAVYNIGPISA 758
Y+ D G + ++ YP+ G + +C ++K+ GF + G E + AV +GP+S
Sbjct: 197 YIKDNGGIDTEKSYPYEGIDDSCHFNKATIGATDTGFVDIPEGDEEKMKKAVATMGPVSV 256
Query: 759 AIDASPNTFKQYKTGIYDD 815
AIDAS +F+ Y G+Y++
Sbjct: 257 AIDASHESFQLYSEGVYNE 275
>sp|Q9JL96|CATM_MOUSE Cathepsin M precursor
Length = 333
Score = 149 bits (377), Expect = 7e-36
Identities = 89/256 (34%), Positives = 139/256 (54%), Gaps = 1/256 (0%)
Frame = +3
Query: 45 LNKDWEDYKTIFNKKYSDETDLIRRNIWEENLKFIKQHNLQFDLGKTKFSVGLNEFSDMN 224
L+ +W+ +K + K YS E + +R +WE+N+K IK HN + LGK F++ +N F DM
Sbjct: 25 LDVEWQKWKIKYGKAYSLEEEGQKRAVWEDNMKKIKLHNGENGLGKHGFTMEMNAFGDMT 84
Query: 225 QKEFQSNILSVXXXXXXXXXXXXXXXXXXLSRNDFITTPNNIKLPDSWDWREKGAVSPVG 404
+EF+ ++ + + + + ++ LP +W+++G V+PV
Sbjct: 85 LEEFRKVMIEIPVPT--------------VKKGKSVQKRLSVNLPKFINWKKRGYVTPVQ 130
Query: 405 NQ-RNNCCGYAFAAAGALEGQNFNLTKTLEILSKQQIIDCSIYYGNSNCYSGCILSKAYA 581
Q R N C +AF+ GA+EGQ F T L LS Q ++DCS GN CY G +
Sbjct: 131 TQGRCNSC-WAFSVTGAIEGQMFRKTGQLIPLSVQNLVDCSRPQGNWGCYLGNTYLALHY 189
Query: 582 YLADYGSELDEDYPFVGYNSNCKYDKSLATVKPYGFKYVSRGKEADLMNAVYNIGPISAA 761
+ + G E + YP+ + +C+Y +T GF++V + ++A LMNAV +IGPIS A
Sbjct: 190 VMENGGLESEATYPYEEKDGSCRYSPENSTANITGFEFVPKNEDA-LMNAVASIGPISVA 248
Query: 762 IDASPNTFKQYKTGIY 809
IDA +F YK GIY
Sbjct: 249 IDARHASFLFYKRGIY 264
>sp|Q95029|CATL_DROME Cathepsin L precursor (Cysteine proteinase 1) [Contains: Cathepsin
L heavy chain; Cathepsin L light chain]
Length = 341
Score = 149 bits (375), Expect = 1e-35
Identities = 84/257 (32%), Positives = 137/257 (53%), Gaps = 2/257 (0%)
Frame = +3
Query: 51 KDWEDYKTIFNKKYSDETD-LIRRNIWEENLKFIKQHNLQFDLGKTKFSVGLNEFSDMNQ 227
++W +K K Y DET+ R I+ EN I +HN +F GK F + +N+++D+
Sbjct: 27 EEWHTFKLEHRKNYQDETEERFRLKIFNENKHKIAKHNQRFAEGKVSFKLAVNKYADLLH 86
Query: 228 KEFQSNILSVXXXXXXXXXXXXXXXXXXLSRNDFITTPNNIKLPDSWDWREKGAVSPVGN 407
EF+ + FI+ P ++ LP S DWR KGAV+ V +
Sbjct: 87 HEFRQ----LMNGFNYTLHKQLRAADESFKGVTFIS-PAHVTLPKSVDWRTKGAVTAVKD 141
Query: 408 QRNNCCGYAFAAAGALEGQNFNLTKTLEILSKQQIIDCSIYYGNSNCYSGCILSKAYAYL 587
Q + +AF++ GALEGQ+F + L LS+Q ++DCS YGN+ C +G ++ A+ Y+
Sbjct: 142 QGHCGSCWAFSSTGALEGQHFRKSGVLVSLSEQNLVDCSTKYGNNGC-NGGLMDNAFRYI 200
Query: 588 ADYGS-ELDEDYPFVGYNSNCKYDKSLATVKPYGFKYVSRGKEADLMNAVYNIGPISAAI 764
D G + ++ YP+ + +C ++K GF + +G E + AV +GP+S AI
Sbjct: 201 KDNGGIDTEKSYPYEAIDDSCHFNKGTVGATDRGFTDIPQGDEKKMAEAVATVGPVSVAI 260
Query: 765 DASPNTFKQYKTGIYDD 815
DAS +F+ Y G+Y++
Sbjct: 261 DASHESFQFYSEGVYNE 277
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 75,839,710
Number of Sequences: 369166
Number of extensions: 1318036
Number of successful extensions: 4238
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 3832
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 3987
length of database: 68,354,980
effective HSP length: 109
effective length of database: 48,218,865
effective search space used: 7859674995
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)