Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_025_I16
(803 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q63009|ANM1_RAT Protein arginine N-methyltransferase 1 395 e-110
sp|Q9JIF0|ANM1_MOUSE Protein arginine N-methyltransferase 1 395 e-110
sp|Q99873|ANM1_HUMAN Protein arginine N-methyltransferase 1... 394 e-109
sp|Q6PAK3|ANM4_MOUSE Protein arginine N-methyltransferase 4... 383 e-106
sp|Q9NR22|ANM4_HUMAN Protein arginine N-methyltransferase 4... 382 e-106
sp|Q9URX7|ANM1_SCHPO Probable protein arginine N-methyltran... 293 4e-79
sp|P38074|HMT1_YEAST HNRNP arginine N-methyltransferase (OD... 263 4e-70
sp|O60678|ANM3_HUMAN Protein arginine N-methyltransferase 3... 251 2e-66
sp|O70467|ANM3_RAT Protein arginine N-methyltransferase 3 (... 246 7e-65
sp|Q922H1|ANM3_MOUSE Protein arginine N-methyltransferase 3... 238 1e-62
>sp|Q63009|ANM1_RAT Protein arginine N-methyltransferase 1
Length = 353
Score = 395 bits (1014), Expect = e-110
Identities = 185/257 (71%), Positives = 221/257 (85%)
Frame = +3
Query: 30 DASDMTSKDYYFDSYAHFGIHEEMLKDEVRTLTYRNALYHNKHXXXXXXXXXXGCGTGIL 209
+A DMTSKDYYFDSYAHFGIHEEMLKDEVRTLTYRN+++HN+H G GTGIL
Sbjct: 25 NAEDMTSKDYYFDSYAHFGIHEEMLKDEVRTLTYRNSMFHNRHLFKDKVVLDVGSGTGIL 84
Query: 210 CMFAVKAGAKKVIGIDCSNIIDYAKEIIKANKMEDKITLIKGKVEEVELPEDVLKVDIII 389
CMFA KAGA+KVIGI+CS+I DYA +I+KANK++ +T+IKGKVEEVELP V KVDIII
Sbjct: 85 CMFAAKAGARKVIGIECSSISDYAVKIVKANKLDHVVTIIKGKVEEVELP--VEKVDIII 142
Query: 390 SEWMGYCLFYESMLNTVLFARDKWLKTGGIIMPDKATLHLCAIEDRQYKDEKINWWENVY 569
SEWMGYCLFYESMLNTVL ARDKWL G+I PD+ATL++ AIEDRQYKD KI+WWENVY
Sbjct: 143 SEWMGYCLFYESMLNTVLHARDKWLAPDGLIFPDRATLYVTAIEDRQYKDYKIHWWENVY 202
Query: 570 GFDMSCIRKVAVSEPLVDVVNPNQIVSNFCIVKEVNMYEIKVEDLSFSSPFTLAVRKNDY 749
GFDMSCI+ VA+ EPLVDVV+P Q+V+N C++KEV++Y +KVEDL+F+SPF L V++NDY
Sbjct: 203 GFDMSCIKDVAIKEPLVDVVDPKQLVTNACLIKEVDIYTVKVEDLTFTSPFCLQVKRNDY 262
Query: 750 IHALVAFFNIDFTSSHK 800
+HALVA+FNI+FT HK
Sbjct: 263 VHALVAYFNIEFTRCHK 279
>sp|Q9JIF0|ANM1_MOUSE Protein arginine N-methyltransferase 1
Length = 371
Score = 395 bits (1014), Expect = e-110
Identities = 185/257 (71%), Positives = 221/257 (85%)
Frame = +3
Query: 30 DASDMTSKDYYFDSYAHFGIHEEMLKDEVRTLTYRNALYHNKHXXXXXXXXXXGCGTGIL 209
+A DMTSKDYYFDSYAHFGIHEEMLKDEVRTLTYRN+++HN+H G GTGIL
Sbjct: 43 NAEDMTSKDYYFDSYAHFGIHEEMLKDEVRTLTYRNSMFHNRHLFKDKVVLDVGSGTGIL 102
Query: 210 CMFAVKAGAKKVIGIDCSNIIDYAKEIIKANKMEDKITLIKGKVEEVELPEDVLKVDIII 389
CMFA KAGA+KVIGI+CS+I DYA +I+KANK++ +T+IKGKVEEVELP V KVDIII
Sbjct: 103 CMFAAKAGARKVIGIECSSISDYAVKIVKANKLDHVVTIIKGKVEEVELP--VEKVDIII 160
Query: 390 SEWMGYCLFYESMLNTVLFARDKWLKTGGIIMPDKATLHLCAIEDRQYKDEKINWWENVY 569
SEWMGYCLFYESMLNTVL ARDKWL G+I PD+ATL++ AIEDRQYKD KI+WWENVY
Sbjct: 161 SEWMGYCLFYESMLNTVLHARDKWLAPDGLIFPDRATLYVTAIEDRQYKDYKIHWWENVY 220
Query: 570 GFDMSCIRKVAVSEPLVDVVNPNQIVSNFCIVKEVNMYEIKVEDLSFSSPFTLAVRKNDY 749
GFDMSCI+ VA+ EPLVDVV+P Q+V+N C++KEV++Y +KVEDL+F+SPF L V++NDY
Sbjct: 221 GFDMSCIKDVAIKEPLVDVVDPKQLVTNACLIKEVDIYTVKVEDLTFTSPFCLQVKRNDY 280
Query: 750 IHALVAFFNIDFTSSHK 800
+HALVA+FNI+FT HK
Sbjct: 281 VHALVAYFNIEFTRCHK 297
>sp|Q99873|ANM1_HUMAN Protein arginine N-methyltransferase 1 (Interferon receptor 1-bound
protein 4)
Length = 361
Score = 394 bits (1013), Expect = e-109
Identities = 185/257 (71%), Positives = 221/257 (85%)
Frame = +3
Query: 30 DASDMTSKDYYFDSYAHFGIHEEMLKDEVRTLTYRNALYHNKHXXXXXXXXXXGCGTGIL 209
+A DMTSKDYYFDSYAHFGIHEEMLKDEVRTLTYRN+++HN+H G GTGIL
Sbjct: 33 NAEDMTSKDYYFDSYAHFGIHEEMLKDEVRTLTYRNSMFHNRHLFKDKVVLDVGSGTGIL 92
Query: 210 CMFAVKAGAKKVIGIDCSNIIDYAKEIIKANKMEDKITLIKGKVEEVELPEDVLKVDIII 389
CMFA KAGA+KVIGI CS+I DYA +I+KANK++ +T+IKGKVEEVELP V KVDIII
Sbjct: 93 CMFAAKAGARKVIGIVCSSISDYAVKIVKANKLDHVVTIIKGKVEEVELP--VEKVDIII 150
Query: 390 SEWMGYCLFYESMLNTVLFARDKWLKTGGIIMPDKATLHLCAIEDRQYKDEKINWWENVY 569
SEWMGYCLFYESMLNTVL+ARDKWL G+I PD+ATL++ AIEDRQYKD KI+WWENVY
Sbjct: 151 SEWMGYCLFYESMLNTVLYARDKWLAPDGLIFPDRATLYVTAIEDRQYKDYKIHWWENVY 210
Query: 570 GFDMSCIRKVAVSEPLVDVVNPNQIVSNFCIVKEVNMYEIKVEDLSFSSPFTLAVRKNDY 749
GFDMSCI+ VA+ EPLVDVV+P Q+V+N C++KEV++Y +KVEDL+F+SPF L V++NDY
Sbjct: 211 GFDMSCIKDVAIKEPLVDVVDPKQLVTNACLIKEVDIYTVKVEDLTFTSPFCLQVKRNDY 270
Query: 750 IHALVAFFNIDFTSSHK 800
+HALVA+FNI+FT HK
Sbjct: 271 VHALVAYFNIEFTRCHK 287
>sp|Q6PAK3|ANM4_MOUSE Protein arginine N-methyltransferase 4 (Heterogeneous nuclear
ribonucleoprotein methyltransferase-like protein 4)
Length = 394
Score = 383 bits (983), Expect = e-106
Identities = 177/258 (68%), Positives = 218/258 (84%)
Frame = +3
Query: 27 IDASDMTSKDYYFDSYAHFGIHEEMLKDEVRTLTYRNALYHNKHXXXXXXXXXXGCGTGI 206
++ +MTS+DYYFDSYAHFGIHEEMLKDEVRTLTYRN++YHNKH G GTGI
Sbjct: 65 LNPEEMTSRDYYFDSYAHFGIHEEMLKDEVRTLTYRNSMYHNKHVFKDKVVLDVGSGTGI 124
Query: 207 LCMFAVKAGAKKVIGIDCSNIIDYAKEIIKANKMEDKITLIKGKVEEVELPEDVLKVDII 386
L MFA KAGAKKV GI+CS+I DY+++IIKAN +++ IT+ KGKVEEVELP V KVDII
Sbjct: 125 LSMFAAKAGAKKVFGIECSSISDYSEKIIKANHLDNVITIFKGKVEEVELP--VEKVDII 182
Query: 387 ISEWMGYCLFYESMLNTVLFARDKWLKTGGIIMPDKATLHLCAIEDRQYKDEKINWWENV 566
ISEWMGYCLFYESMLNTV+FARDKWLK GG++ PD+A L++ AIEDRQYKD KI+WWENV
Sbjct: 183 ISEWMGYCLFYESMLNTVIFARDKWLKPGGLMFPDRAALYVVAIEDRQYKDFKIHWWENV 242
Query: 567 YGFDMSCIRKVAVSEPLVDVVNPNQIVSNFCIVKEVNMYEIKVEDLSFSSPFTLAVRKND 746
YGFDM+CIR VA+ EPLVD+V+P Q+V+N C++KEV++Y +K E+LSF+S F L +++ND
Sbjct: 243 YGFDMTCIRDVAMKEPLVDIVDPKQVVTNACLIKEVDIYTVKTEELSFTSAFCLQIQRND 302
Query: 747 YIHALVAFFNIDFTSSHK 800
Y+HALV +FNI+FT HK
Sbjct: 303 YVHALVTYFNIEFTKCHK 320
>sp|Q9NR22|ANM4_HUMAN Protein arginine N-methyltransferase 4 (Heterogeneous nuclear
ribonucleoprotein methyltransferase-like protein 4)
Length = 334
Score = 382 bits (982), Expect = e-106
Identities = 177/258 (68%), Positives = 218/258 (84%)
Frame = +3
Query: 27 IDASDMTSKDYYFDSYAHFGIHEEMLKDEVRTLTYRNALYHNKHXXXXXXXXXXGCGTGI 206
++ +MTS+DYYFDSYAHFGIHEEMLKDEVRTLTYRN++YHNKH G GTGI
Sbjct: 5 LNPEEMTSRDYYFDSYAHFGIHEEMLKDEVRTLTYRNSMYHNKHVFKDKVVLDVGSGTGI 64
Query: 207 LCMFAVKAGAKKVIGIDCSNIIDYAKEIIKANKMEDKITLIKGKVEEVELPEDVLKVDII 386
L MFA KAGAKKV GI+CS+I DY+++IIKAN +++ IT+ KGKVEEVELP V KVDII
Sbjct: 65 LSMFAAKAGAKKVFGIECSSISDYSEKIIKANHLDNIITIFKGKVEEVELP--VEKVDII 122
Query: 387 ISEWMGYCLFYESMLNTVLFARDKWLKTGGIIMPDKATLHLCAIEDRQYKDEKINWWENV 566
ISEWMGYCLFYESMLNTV+FARDKWLK GG++ PD+A L++ AIEDRQYKD KI+WWENV
Sbjct: 123 ISEWMGYCLFYESMLNTVIFARDKWLKPGGLMFPDRAALYVVAIEDRQYKDFKIHWWENV 182
Query: 567 YGFDMSCIRKVAVSEPLVDVVNPNQIVSNFCIVKEVNMYEIKVEDLSFSSPFTLAVRKND 746
YGFDM+CIR VA+ EPLVD+V+P Q+V+N C++KEV++Y +K E+LSF+S F L +++ND
Sbjct: 183 YGFDMTCIRDVAMKEPLVDIVDPKQVVTNACLIKEVDIYTVKTEELSFTSAFCLQIQRND 242
Query: 747 YIHALVAFFNIDFTSSHK 800
Y+HALV +FNI+FT HK
Sbjct: 243 YVHALVTYFNIEFTKCHK 260
>sp|Q9URX7|ANM1_SCHPO Probable protein arginine N-methyltransferase
Length = 339
Score = 293 bits (750), Expect = 4e-79
Identities = 138/255 (54%), Positives = 190/255 (74%)
Frame = +3
Query: 36 SDMTSKDYYFDSYAHFGIHEEMLKDEVRTLTYRNALYHNKHXXXXXXXXXXGCGTGILCM 215
S +T+KDYYFDSY+H+GIHEEMLKD+VRTL+YR+A+ N H GCGTGIL M
Sbjct: 11 SGLTAKDYYFDSYSHWGIHEEMLKDDVRTLSYRDAIMQNPHLFRDKIVLDVGCGTGILSM 70
Query: 216 FAVKAGAKKVIGIDCSNIIDYAKEIIKANKMEDKITLIKGKVEEVELPEDVLKVDIIISE 395
F +AGAK V G+D S II A +I++ NK+ D+ITLI+GK+EE++LP V KVDII+SE
Sbjct: 71 FCARAGAKHVYGVDMSEIIHKAVQIVEVNKLSDRITLIQGKMEEIQLP--VEKVDIIVSE 128
Query: 396 WMGYCLFYESMLNTVLFARDKWLKTGGIIMPDKATLHLCAIEDRQYKDEKINWWENVYGF 575
WMGY L YESML+TVL ARD++L G++ PD+A + L AIED YK EKI +W++VYGF
Sbjct: 129 WMGYFLLYESMLDTVLVARDRYLAPDGLLFPDRAQIQLAAIEDADYKSEKIGFWDDVYGF 188
Query: 576 DMSCIRKVAVSEPLVDVVNPNQIVSNFCIVKEVNMYEIKVEDLSFSSPFTLAVRKNDYIH 755
D S I+K EPLVD V+ + +N C++ ++++ +K EDL+FSSPF + +ND++H
Sbjct: 189 DFSPIKKDVWKEPLVDTVDRIAVNTNSCVILDLDLKTVKKEDLAFSSPFEITATRNDFVH 248
Query: 756 ALVAFFNIDFTSSHK 800
A +A+F+I+F++ HK
Sbjct: 249 AFLAWFDIEFSACHK 263
>sp|P38074|HMT1_YEAST HNRNP arginine N-methyltransferase (ODP1 protein)
Length = 348
Score = 263 bits (672), Expect = 4e-70
Identities = 128/246 (52%), Positives = 174/246 (70%)
Frame = +3
Query: 48 SKDYYFDSYAHFGIHEEMLKDEVRTLTYRNALYHNKHXXXXXXXXXXGCGTGILCMFAVK 227
S+ +YF+SY H+GIHEEML+D VRTL+YRNA+ NK GCGTGIL MFA K
Sbjct: 19 SEQHYFNSYDHYGIHEEMLQDTVRTLSYRNAIIQNKDLFKDKIVLDVGCGTGILSMFAAK 78
Query: 228 AGAKKVIGIDCSNIIDYAKEIIKANKMEDKITLIKGKVEEVELPEDVLKVDIIISEWMGY 407
GAK VIG+D S+II+ AKE+++ N DKITL++GK+E+V LP KVDIIISEWMGY
Sbjct: 79 HGAKHVIGVDMSSIIEMAKELVELNGFSDKITLLRGKLEDVHLPFP--KVDIIISEWMGY 136
Query: 408 CLFYESMLNTVLFARDKWLKTGGIIMPDKATLHLCAIEDRQYKDEKINWWENVYGFDMSC 587
L YESM++TVL+ARD +L GG+I PDK ++HL +ED QYKDEK+N+W++VYGFD S
Sbjct: 137 FLLYESMMDTVLYARDHYLVEGGLIFPDKCSIHLAGLEDSQYKDEKLNYWQDVYGFDYSP 196
Query: 588 IRKVAVSEPLVDVVNPNQIVSNFCIVKEVNMYEIKVEDLSFSSPFTLAVRKNDYIHALVA 767
+ + EP+VD V N + + + E ++ +K+ DL+F S F L ++ D I+ +V
Sbjct: 197 FVPLVLHEPIVDTVERNNVNTTSDKLIEFDLNTVKISDLAFKSNFKLTAKRQDMINGIVT 256
Query: 768 FFNIDF 785
+F+I F
Sbjct: 257 WFDIVF 262
>sp|O60678|ANM3_HUMAN Protein arginine N-methyltransferase 3 (Heterogeneous nuclear
ribonucleoprotein methyltransferase-like protein 3)
Length = 531
Score = 251 bits (641), Expect = 2e-66
Identities = 120/242 (49%), Positives = 168/242 (69%)
Frame = +3
Query: 60 YFDSYAHFGIHEEMLKDEVRTLTYRNALYHNKHXXXXXXXXXXGCGTGILCMFAVKAGAK 239
YF SY H+GIHEEMLKD++RT +YR+ +Y N H GCGTGIL MFA KAGAK
Sbjct: 220 YFSSYGHYGIHEEMLKDKIRTESYRDFIYQNPHIFKDKVVLDVGCGTGILSMFAAKAGAK 279
Query: 240 KVIGIDCSNIIDYAKEIIKANKMEDKITLIKGKVEEVELPEDVLKVDIIISEWMGYCLFY 419
KV+G+D S I+ A +II+ NK+ED ITLIKGK+EEV LP V KVD+IISEWMGY L +
Sbjct: 280 KVLGVDQSEILYQAMDIIRLNKLEDTITLIKGKIEEVHLP--VEKVDVIISEWMGYFLLF 337
Query: 420 ESMLNTVLFARDKWLKTGGIIMPDKATLHLCAIEDRQYKDEKINWWENVYGFDMSCIRKV 599
ESML++VL+A++K+L GG + PD T+ L A+ D ++I +W++VYGF MSC++K
Sbjct: 338 ESMLDSVLYAKNKYLAKGGSVYPDICTISLVAVSDVNKHADRIAFWDDVYGFKMSCMKKA 397
Query: 600 AVSEPLVDVVNPNQIVSNFCIVKEVNMYEIKVEDLSFSSPFTLAVRKNDYIHALVAFFNI 779
+ E +V+V++P ++S C +K ++ + + DL FSS FTL + + A+ +F+I
Sbjct: 398 VIPEAVVEVLDPKTLISEPCGIKHIDCHTTSISDLEFSSDFTLKITRTSMCTAIAGYFDI 457
Query: 780 DF 785
F
Sbjct: 458 YF 459
>sp|O70467|ANM3_RAT Protein arginine N-methyltransferase 3 (Heterogeneous nuclear
ribonucleoprotein methyltransferase-like protein 3)
Length = 528
Score = 246 bits (627), Expect = 7e-65
Identities = 121/242 (50%), Positives = 165/242 (68%)
Frame = +3
Query: 60 YFDSYAHFGIHEEMLKDEVRTLTYRNALYHNKHXXXXXXXXXXGCGTGILCMFAVKAGAK 239
YF SY H+GIHEEMLKD+VRT +YR+ +Y N H GCGTGIL MFA KAGAK
Sbjct: 217 YFSSYGHYGIHEEMLKDKVRTESYRDFIYQNPHIFKDKVVLDVGCGTGILSMFAAKAGAK 276
Query: 240 KVIGIDCSNIIDYAKEIIKANKMEDKITLIKGKVEEVELPEDVLKVDIIISEWMGYCLFY 419
KVI +D S I+ A +II+ NK+ED I LIKGK+EEV LP V KVD+IISEWMGY L +
Sbjct: 277 KVIAVDQSEILYQAMDIIRLNKLEDTIVLIKGKIEEVSLP--VEKVDVIISEWMGYFLLF 334
Query: 420 ESMLNTVLFARDKWLKTGGIIMPDKATLHLCAIEDRQYKDEKINWWENVYGFDMSCIRKV 599
ESML++VL+A+ K+L GG + PD T+ L A+ D ++I +W++VYGF+MSC++K
Sbjct: 335 ESMLDSVLYAKSKYLAKGGSVYPDICTISLVAVSDVSKHADRIAFWDDVYGFNMSCMKKA 394
Query: 600 AVSEPLVDVVNPNQIVSNFCIVKEVNMYEIKVEDLSFSSPFTLAVRKNDYIHALVAFFNI 779
+ E +V+VV+ ++S+ C +K ++ + + DL FSS FTL K A+ +F+I
Sbjct: 395 VIPEAVVEVVDHKTLISDPCDIKHIDCHTTSISDLEFSSDFTLRTTKTAMCTAVAGYFDI 454
Query: 780 DF 785
F
Sbjct: 455 YF 456
>sp|Q922H1|ANM3_MOUSE Protein arginine N-methyltransferase 3 (Heterogeneous nuclear
ribonucleoprotein methyltransferase-like protein 3)
Length = 532
Score = 238 bits (608), Expect = 1e-62
Identities = 120/246 (48%), Positives = 164/246 (66%), Gaps = 4/246 (1%)
Frame = +3
Query: 60 YFDSYAHFGIHEEMLKDEVRTLTYRNALYHNKHXXXXXXXXXXGCGTGILCMFAVKAGAK 239
YF SY H+GIHEEMLKD+VRT +YR+ +Y N H GCGTGIL MFA K GAK
Sbjct: 217 YFSSYGHYGIHEEMLKDKVRTESYRDFIYQNPHIFKDKVVLDVGCGTGILSMFAAKVGAK 276
Query: 240 KVIGIDCSNIIDYAKEIIKANKMEDKITLIKGKVEEVELPEDVLKVDIIISEWMGYCLFY 419
KVI +D S I+ A +II+ NK+ED I LIKGK+EEV LP V KVD+IISEWMGY L +
Sbjct: 277 KVIAVDQSEILYQAMDIIRLNKLEDTIVLIKGKIEEVSLP--VEKVDVIISEWMGYFLLF 334
Query: 420 ESMLNTVLFARDKWLKTGGIIMPDKATLHLCAIEDRQYKDEKINWWENVYGFDMSCIRKV 599
ESML++VL+A+ K+L GG + PD T+ L A+ D ++I +W++VYGF+MSC++K
Sbjct: 335 ESMLDSVLYAKSKYLAKGGSVYPDICTISLVAVSDVSKHADRIAFWDDVYGFNMSCMKKA 394
Query: 600 AVSEPLVDVVNPNQIVSNFCIV----KEVNMYEIKVEDLSFSSPFTLAVRKNDYIHALVA 767
+ E +V+VV+ ++S+ C + K ++ + + DL FSS FTL K A+
Sbjct: 395 VIPEAVVEVVDHKTLISDPCDIKMDGKHIDCHTTSISDLEFSSDFTLRTTKTAMCTAVAG 454
Query: 768 FFNIDF 785
+F+I F
Sbjct: 455 YFDIYF 460
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 80,876,083
Number of Sequences: 369166
Number of extensions: 1481669
Number of successful extensions: 4312
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 4153
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 4288
length of database: 68,354,980
effective HSP length: 109
effective length of database: 48,218,865
effective search space used: 7618580670
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)