Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_025_F23
(877 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q8VDL4|ADPGK_MOUSE ADP-dependent glucokinase (ADPGK) (AD... 110 5e-24
sp|Q9BRR6|ADPGK_HUMAN ADP-dependent glucokinase (ADPGK) (AD... 108 3e-23
sp|Q9V1A6|K6PF_PYRAB ADP-specific phosphofructokinase (ADP-... 58 3e-08
sp|O59355|K6PF_PYRHO ADP-specific phosphofructokinase (ADP-... 58 3e-08
sp|Q9V2Z7|K6PF_PYRFU ADP-specific phosphofructokinase (ADP-... 58 4e-08
sp|Q977Q3|K6PF_THELI ADP-specific phosphofructokinase (ADP-... 58 4e-08
sp|Q5JD05|K6PF_PYRKO ADP-specific phosphofructokinase (ADP-... 54 6e-07
sp|Q9HH12|K6PF_THEZI ADP-specific phosphofructokinase (ADP-... 53 1e-06
sp|Q5JE39|GLKA_PYRKO ADP-dependent glucokinase (ADPGK) (ADP... 46 1e-04
sp|Q9V2Z6|GLKA_PYRFU ADP-dependent glucokinase (ADPGK) (ADP... 45 3e-04
>sp|Q8VDL4|ADPGK_MOUSE ADP-dependent glucokinase (ADPGK) (ADP-GK)
Length = 496
Score = 110 bits (275), Expect = 5e-24
Identities = 80/254 (31%), Positives = 122/254 (48%), Gaps = 3/254 (1%)
Frame = +1
Query: 4 LEKLESKIKAFKPDIFVLGGLQMMDGFPYQKGEMNEQINRLERFLATIPKDVPIHFEMAS 183
LE S ++ F+PD+ VL GL MM+G K +++ + ++ IP +P+H E+AS
Sbjct: 243 LEVFVSSLEEFQPDLVVLSGLHMMEG--QSKELQRKRLLEVVTAISDIPTGIPVHLELAS 300
Query: 184 FIEKQFFLKLKNQ-IIPYADSLGFNEQELPNLFSILDSDSITTLST--AYPRTSHMLDHM 354
++ + +Q + P SLG NEQEL L S S ++LS+ P + D +
Sbjct: 301 MTNRELMSSIVHQQVFPAVASLGLNEQELLFL-SQSASGPHSSLSSWDGVPDVGMVSDIL 359
Query: 355 RRVWEIIVDQLPSNGTRNKLSRLHLHTIGYQIIMTNKHSKFWHSSRSAVAKASLVAHRYT 534
W I+ + S + L+R+H HT+ Y I+ T W + +AVA + VA
Sbjct: 360 --FW-ILKEHGRSENRASDLTRIHFHTLVYHILATV--DGHWANQLAAVAAGARVAGTQA 414
Query: 535 CGIHNVDIERSKLLMDDSFSISEIPNSPRVHFNFTDPVSCWEERELEICVAPVLVCTKVI 714
C +D R L F+ S + + R+ N PV W + PVLVC +
Sbjct: 415 CATETIDTNRVSLRAPQEFTTSHLESGSRIVLNPDKPVVEWHREGITFHFTPVLVCKDPV 474
Query: 715 RTVGGGDNISSAAL 756
RTVG GD IS+ L
Sbjct: 475 RTVGLGDAISAEGL 488
>sp|Q9BRR6|ADPGK_HUMAN ADP-dependent glucokinase (ADPGK) (ADP-GK) (RbBP-35)
Length = 497
Score = 108 bits (269), Expect = 3e-23
Identities = 78/253 (30%), Positives = 114/253 (45%), Gaps = 2/253 (0%)
Frame = +1
Query: 4 LEKLESKIKAFKPDIFVLGGLQMMDGFPYQKGEMNEQINRLERFLATIPKDVPIHFEMAS 183
LE S ++ F+PD+ VL GL MM+G K +++ + ++ IP +P+H E+AS
Sbjct: 243 LEVFVSSLEEFQPDLVVLSGLHMMEG--QSKELQRKRLLEVVTSISDIPTGIPVHLELAS 300
Query: 184 FIEKQFFLKLKNQ-IIPYADSLGFNEQELPNLFSILDSDSITTLS-TAYPRTSHMLDHMR 357
++ + +Q + P SLG NEQEL L + S P + D +
Sbjct: 301 MTNRELMSSIVHQQVFPAVTSLGLNEQELLFLTQSASGPHSSLSSWNGVPDVGMVSDIL- 359
Query: 358 RVWEIIVDQLPSNGTRNKLSRLHLHTIGYQIIMTNKHSKFWHSSRSAVAKASLVAHRYTC 537
W I+ + S + L+R+H HT+ Y I+ T W + +AVA + VA C
Sbjct: 360 -FW-ILKEHGRSKSRASDLTRIHFHTLVYHILATV--DGHWANQLAAVAAGARVAGTQAC 415
Query: 538 GIHNVDIERSKLLMDDSFSISEIPNSPRVHFNFTDPVSCWEERELEICVAPVLVCTKVIR 717
+D R L F S R+ N PV W + PVLVC IR
Sbjct: 416 ATETIDTSRVSLRAPQEFMTSHSEAGSRIVLNPNKPVVEWHREGISFHFTPVLVCKDPIR 475
Query: 718 TVGGGDNISSAAL 756
TVG GD IS+ L
Sbjct: 476 TVGLGDAISAEGL 488
>sp|Q9V1A6|K6PF_PYRAB ADP-specific phosphofructokinase (ADP-dependent
phosphofructokinase) (ADP-Pfk)
Length = 451
Score = 58.2 bits (139), Expect = 3e-08
Identities = 57/217 (26%), Positives = 97/217 (44%), Gaps = 6/217 (2%)
Frame = +1
Query: 127 ERFLATIPKDVPIHFEMASFIEKQFFLKLKNQIIPYADSLGFNEQELPNLFSILDSDSIT 306
E ++ +DV +H E+AS +++ K+ I+P ADS+G +E E+ L S+L +
Sbjct: 246 EDIISLKEEDVKVHVELASIQDRKLRKKVITNILPIADSVGIDEAEIAQLLSVLGYRDLA 305
Query: 307 TLSTAYPRTSHMLDHMRRVWEIIVDQLPSNGTRNKLSRLHLHTIGYQIIMTNKHSKFWHS 486
Y R L+ II+D+L L +HTI Y + +T++ +
Sbjct: 306 DRIFTYNR----LEDSILGGMIILDEL-------NFEILQVHTIYYLMYITHRDNPLSEE 354
Query: 487 S--RSAVAKASLVAHRYTCGIHNVDIERSKLLMDDSFSIS-EIPNSPR---VHFNFTDPV 648
+S +L A R + G DI R + + I ++P + R V F +
Sbjct: 355 ELMKSLEFGTTLAAARASLG----DINR-----PEDYEIGLKVPFNERSEYVKLRFEEAK 405
Query: 649 SCWEERELEICVAPVLVCTKVIRTVGGGDNISSAALL 759
+ RE ++ V P + + TVG GD IS+ A +
Sbjct: 406 TKLRMREYKVVVIPTRLVPNPVLTVGLGDTISAGAFI 442
>sp|O59355|K6PF_PYRHO ADP-specific phosphofructokinase (ADP-dependent
phosphofructokinase) (ADP-Pfk)
Length = 450
Score = 58.2 bits (139), Expect = 3e-08
Identities = 58/211 (27%), Positives = 92/211 (43%), Gaps = 5/211 (2%)
Frame = +1
Query: 151 KDVPIHFEMASFIEKQFFLKLKNQIIPYADSLGFNEQELPNLFSILDSDSITTLSTAYPR 330
KDV IH E AS +++ K+ I+P+ DS+G +E E+ + S+L + Y R
Sbjct: 253 KDVKIHVEFASVQDRKLRKKIITNILPFVDSVGIDEAEIAQILSVLGYRELADRIFTYNR 312
Query: 331 TSHMLDHMRRVWEIIVDQLPSNGTRNKLSRLHLHTIGYQIIMTNKHSKFWHS--SRSAVA 504
L+ II+D+L L +HT Y + +T++ + ++S
Sbjct: 313 ----LEDSILGGMIILDEL-------NFEILQVHTTYYLMYITHRDNPLSEEELAKSLEF 361
Query: 505 KASLVAHRYTCGIHNVDIERSKLLMDDSFSISEIPNSPR---VHFNFTDPVSCWEERELE 675
+L A R + G DI DD ++P + R V F + S RE +
Sbjct: 362 GTTLAAARASLG----DIRGP----DDYKVGLKVPFNERSEYVKLRFEEAKSRLRMREYK 413
Query: 676 ICVAPVLVCTKVIRTVGGGDNISSAALLNQL 768
+ V P + + TVG GD IS+ A L L
Sbjct: 414 VVVIPTRLVQNPVLTVGLGDTISAGAFLTYL 444
>sp|Q9V2Z7|K6PF_PYRFU ADP-specific phosphofructokinase (ADP-dependent
phosphofructokinase) (ADP-Pfk)
Length = 454
Score = 57.8 bits (138), Expect = 4e-08
Identities = 66/270 (24%), Positives = 116/270 (42%), Gaps = 13/270 (4%)
Frame = +1
Query: 4 LEKLESK--IKAFKPDIFVLGGLQMMDGFP-----YQKG-EMNEQINRLERFLATIPK-- 153
+ ++E+K ++ F P+I + ++ G+ Y G + N + R + + + K
Sbjct: 197 ISRIETKDELRKFLPEIGEMVDGAILSGYQGIRLQYSDGKDANYYLRRAKEDIRLLKKNK 256
Query: 154 DVPIHFEMASFIEKQFFLKLKNQIIPYADSLGFNEQELPNLFSILDSDSITTLSTAYPRT 333
D+ IH E AS +++ K+ N I P DS+G +E E+ + S+L + Y R
Sbjct: 257 DIKIHVEFASIQDRRLRKKVVNNIFPMVDSVGMDEAEIAYILSVLGYSDLADRIFMYNRI 316
Query: 334 SH-MLDHMRRVWEIIVDQLPSNGTRNKLSRLHLHTIGYQIIMTNKHSKFWHSS--RSAVA 504
+L M II+D+L L +HTI Y + +T++ + RS
Sbjct: 317 EDAILGGM-----IILDEL-------NFEILQVHTIYYLMYITHRDNPLSEEELMRSLDF 364
Query: 505 KASLVAHRYTCGIHNVDIERSKLLMDDSFSISEIPNSPRVHFNFTDPVSCWEERELEICV 684
L A R + G N D K+ M S+ S + F + +E ++ +
Sbjct: 365 GTILAATRASLGDIN-DPRDVKVGM----SVPYNERSEYIKLRFEEAKRKLRLKEYKVVI 419
Query: 685 APVLVCTKVIRTVGGGDNISSAALLNQLRI 774
P + + TVG GD IS+ L+ L +
Sbjct: 420 VPTRLVPNPVSTVGLGDTISTGTFLSYLSL 449
>sp|Q977Q3|K6PF_THELI ADP-specific phosphofructokinase (ADP-dependent
phosphofructokinase) (ADP-Pfk)
Length = 459
Score = 57.8 bits (138), Expect = 4e-08
Identities = 60/261 (22%), Positives = 112/261 (42%), Gaps = 10/261 (3%)
Frame = +1
Query: 22 KIKAFKPDI------FVLGGLQMMDGFPYQKGEMNEQINRLERFLATIPK--DVPIHFEM 177
++K + P+I +L G Q + + + N + + + + + K D+ IH E
Sbjct: 210 ELKPYLPEIGEMVDGAILSGYQGLRRYYSDGKDANYYLRKAKEDIKLLKKKKDIKIHVEF 269
Query: 178 ASFIEKQFFLKLKNQIIPYADSLGFNEQELPNLFSILDSDSITTLSTAYPRTSHMLDHMR 357
AS +++ K+ I P DS+G +E E+ ++ S+L ++ Y R + +
Sbjct: 270 ASIQDRELRKKVIYNIFPLVDSVGMDEAEIAHILSVLGYRELSDRIFTYNRIEDAVLGAK 329
Query: 358 RVWEIIVDQLPSNGTRNKLSRLHLHTIGYQIIMTNKHSKFWHS--SRSAVAKASLVAHRY 531
I++D+L L L +HTI Y + +T+ + ++S +L A R
Sbjct: 330 ----ILLDEL-------NLEILQVHTIYYLMYITHNDNPLTEEELTKSLEVGTTLAAARA 378
Query: 532 TCGIHNVDIERSKLLMDDSFSISEIPNSPRVHFNFTDPVSCWEERELEICVAPVLVCTKV 711
G DI+R + + +I V F + + RE +I + P +
Sbjct: 379 FLG----DIKRPE-DVKVGLNIPFNEKGEYVKLRFEEAKAKMRTREYKIVIIPTRLVRNP 433
Query: 712 IRTVGGGDNISSAALLNQLRI 774
+ TVG GD IS+ A + L +
Sbjct: 434 VSTVGLGDTISAGAFASYLSL 454
>sp|Q5JD05|K6PF_PYRKO ADP-specific phosphofructokinase (ADP-dependent
phosphofructokinase) (ADP-Pfk)
Length = 461
Score = 53.9 bits (128), Expect = 6e-07
Identities = 64/270 (23%), Positives = 111/270 (41%), Gaps = 19/270 (7%)
Frame = +1
Query: 16 ESKIKAFKPDI------FVLGG-----LQMMDGFP--YQKGEMNEQINRLERFLATIPKD 156
E ++K F P+I +L G L+ DG Y E + I L+R KD
Sbjct: 208 EPELKPFLPEIGQRVDGAILSGYQGIKLRYSDGKDANYYLREAKKDILLLKR-----EKD 262
Query: 157 VPIHFEMASFIEKQFFLKLKNQIIPYADSLGFNEQELPNLFSILDSDSITTLSTAYPRTS 336
V +H E AS ++ K+ + P DS+G +E E+ + S L D + Y R
Sbjct: 263 VKVHLEFASIQNRELRKKVIYNLFPLVDSVGMDEAEIAYVLSALGYDKLAERIFTYNR-- 320
Query: 337 HMLDHMRRVWEIIVDQLPSNGTRNKLSRLHLHTIGYQIIMTNKHSKFWHSS--RSAVAKA 510
++ +I++D++ L L +HTI Y + + + ++ + +S
Sbjct: 321 --IEDTVLGGKILIDEM-------NLELLQIHTIYYIMYIAHANNPLSEAELRQSLELAT 371
Query: 511 SLVAHRYTCGIHNVDIERSKLLMDDSFSIS-EIPNSPR---VHFNFTDPVSCWEERELEI 678
+L A R + G + D S+ +P + R V F + +E ++
Sbjct: 372 TLAASRASLG---------DIASPDQISVGMNVPYNERGEYVKLRFEEAKRRLRTKEYKL 422
Query: 679 CVAPVLVCTKVIRTVGGGDNISSAALLNQL 768
+ P + + TVG GD IS+ A + L
Sbjct: 423 VIIPTRLVQNPVSTVGLGDTISTGAFTSYL 452
>sp|Q9HH12|K6PF_THEZI ADP-specific phosphofructokinase (ADP-dependent
phosphofructokinase) (ADP-Pfk)
Length = 461
Score = 53.1 bits (126), Expect = 1e-06
Identities = 51/212 (24%), Positives = 88/212 (41%), Gaps = 6/212 (2%)
Frame = +1
Query: 151 KDVPIHFEMASFIEKQFFLKLKNQIIPYADSLGFNEQELPNLFSILDSDSITTLSTAYPR 330
KD+ +H E AS ++ K+ + P ADS+G +E E+ + S L D + Y R
Sbjct: 261 KDLKVHLEFASIQSRELRKKVIYNLFPLADSVGMDEAEIAYVLSALGYDELADRIFTYNR 320
Query: 331 TSHMLDHMRRVWEIIVDQLPSNGTRNKLSRLHLHTIGYQIIMTNKHSKFWHSS--RSAVA 504
++ +I++D++ L L +HTI Y + +T+ + RS
Sbjct: 321 ----IEDTVLGGKILLDEM-------NLDVLQIHTIYYIMYITHADNPLSEEELRRSLEL 369
Query: 505 KASLVAHRYTCGIHNVDIERSKLLMDDSFSIS-EIPNSPR---VHFNFTDPVSCWEEREL 672
+L A R + G + D I +P + R V F + +E
Sbjct: 370 ATTLAASRASLG---------DITSPDQIEIGLRVPYNERGEYVKLRFEEAKRKLRTKEY 420
Query: 673 EICVAPVLVCTKVIRTVGGGDNISSAALLNQL 768
++ + P + + TVG GD IS+ A + L
Sbjct: 421 KLVIIPTRLVQNPVSTVGLGDTISTGAFASYL 452
>sp|Q5JE39|GLKA_PYRKO ADP-dependent glucokinase (ADPGK) (ADP-GK)
Length = 453
Score = 46.2 bits (108), Expect = 1e-04
Identities = 50/249 (20%), Positives = 101/249 (40%), Gaps = 1/249 (0%)
Frame = +1
Query: 31 AFKPDIFVLGGLQMMDGFPYQKGEMNEQINRLERFLATIP-KDVPIHFEMASFIEKQFFL 207
A K ++ ++ GLQ + +G E ++ L + K +P H E A F +
Sbjct: 222 AEKTELAIISGLQALT-----EGNYREPFETIKEHLDVLEGKGIPAHLEFA-FTPDETVR 275
Query: 208 KLKNQIIPYADSLGFNEQELPNLFSILDSDSITTLSTAYPRTSHMLDHMRRVWEIIVDQL 387
K ++ S+G NE EL ++ ++ ++ A+ ++ V + ++
Sbjct: 276 KEILGVLGKFWSVGLNEVELASIMDVMGEKTLAEKLLAHDPVDPIV-----VTKAMLKLA 330
Query: 388 PSNGTRNKLSRLHLHTIGYQIIMTNKHSKFWHSSRSAVAKASLVAHRYTCGIHNVDIERS 567
G R R+H HT GY + +T+ +F + A A+ A + N+D
Sbjct: 331 EKTGVR----RIHFHTYGYYLALTDYRGEFVRDALLFAALAA-AAKAKLGDVRNIDDVVK 385
Query: 568 KLLMDDSFSISEIPNSPRVHFNFTDPVSCWEERELEICVAPVLVCTKVIRTVGGGDNISS 747
+ + + + + + + ++ E ++ P + K TVG GD ISS
Sbjct: 386 AMDVPVNEKAKGVEEALTKEYGMENGIA--EVNGYQLAFIPTKIVAKPKSTVGIGDTISS 443
Query: 748 AALLNQLRI 774
+A + + +
Sbjct: 444 SAFVGEFAL 452
>sp|Q9V2Z6|GLKA_PYRFU ADP-dependent glucokinase (ADPGK) (ADP-GK)
Length = 455
Score = 45.1 bits (105), Expect = 3e-04
Identities = 40/205 (19%), Positives = 84/205 (40%)
Frame = +1
Query: 151 KDVPIHFEMASFIEKQFFLKLKNQIIPYADSLGFNEQELPNLFSILDSDSITTLSTAYPR 330
+++P+H E A +++ ++ N ++ S+G NE EL ++ IL + A+
Sbjct: 259 REIPVHLEFAFTPDEKVREEILN-VLGMFYSVGLNEVELASIMEILGEKKLAKELLAHDP 317
Query: 331 TSHMLDHMRRVWEIIVDQLPSNGTRNKLSRLHLHTIGYQIIMTNKHSKFWHSSRSAVAKA 510
+ + + + + + R+H HT GY + +T + + A A
Sbjct: 318 VDPIA---------VTEAMLKLAKKTGVKRIHFHTYGYYLALTEYKGEHVRDALLFAALA 368
Query: 511 SLVAHRYTCGIHNVDIERSKLLMDDSFSISEIPNSPRVHFNFTDPVSCWEERELEICVAP 690
+ A I +++ R + + +++ R + + + E +I P
Sbjct: 369 A-AAKAMKGNITSLEEIREATSVPVNEKATQVEEKLRAEYGIKEGIG--EVEGYQIAFIP 425
Query: 691 VLVCTKVIRTVGGGDNISSAALLNQ 765
+ K TVG GD ISS+A + +
Sbjct: 426 TKIVAKPKSTVGIGDTISSSAFIGE 450
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 101,211,186
Number of Sequences: 369166
Number of extensions: 2045507
Number of successful extensions: 4590
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 4434
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 4570
length of database: 68,354,980
effective HSP length: 110
effective length of database: 48,034,130
effective search space used: 8694177530
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)