Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_025_F06
(604 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P23785|GRN_RAT Granulins precursor [Contains: Acrogranin... 116 4e-26
sp|P28797|GRN_CAVPO Granulins precursor (Proepithelin) (PEP... 115 9e-26
sp|P28798|GRN_MOUSE Granulins precursor (Acrogranin) (Proep... 114 2e-25
sp|P28799|GRN_HUMAN Granulins precursor (Proepithelin) (PEP... 113 3e-25
sp|P80059|PMD1_LOCMI Pars intercerebralis major peptide D1 ... 64 4e-10
sp|P80930|ENA1_HORSE Antimicrobial peptide eNAP-1 59 7e-09
sp|P81013|GRN1_CYPCA Granulin-1 55 1e-07
sp|P81015|GRN3_CYPCA Granulin-3 54 3e-07
sp|P81014|GRN2_CYPCA Granulin-2 50 4e-06
sp|O42182|FBLN1_BRARE Fibulin-1 precursor 44 3e-04
>sp|P23785|GRN_RAT Granulins precursor [Contains: Acrogranin; Granulin-1 (Granulin G);
Granulin-2 (Granulin F); Granulin-3 (Granulin B)
(Epithelin-2); Granulin-4 (Granulin A) (Epithelin-1);
Granulin-5 (Granulin C); Granulin-6 (Granulin D);
Granulin-7 (Granulin E)]
Length = 588
Score = 116 bits (291), Expect = 4e-26
Identities = 56/151 (37%), Positives = 73/151 (48%), Gaps = 2/151 (1%)
Frame = +2
Query: 71 ICQNGKALCGDQKTCCASKSGGHQCCQYSNAVCCGDQLHCCPEGTTCDLVNKRCIHQSNE 250
+C + K C D TCC +G + CC NA+CC D LHCCP+ T CDL+ +CI +
Sbjct: 205 VCPDAKTQCPDDSTCCELPTGKYGCCPMPNAICCSDHLHCCPQDTVCDLIQSKCISK--- 261
Query: 251 PIEWPVVETIDSAKIETPKYTVERSTLREFMVKIGDKNNCPDGGQCAGLQTCCLMYTGHY 430
+ + P Y V VK + +CPDG TCC + TG +
Sbjct: 262 -------DYTTDLMTKLPGYPVNE-------VKCDLEVSCPDG------YTCCRLNTGAW 301
Query: 431 GCCPFSLGVCCPDLRTCCAPGYHC--VTGGC 517
GCCPF+ VCC D CC G+ C TG C
Sbjct: 302 GCCPFTKAVCCEDHIHCCPAGFQCHTETGTC 332
Score = 97.1 bits (240), Expect = 3e-20
Identities = 49/143 (34%), Positives = 63/143 (44%)
Frame = +2
Query: 74 CQNGKALCGDQKTCCASKSGGHQCCQYSNAVCCGDQLHCCPEGTTCDLVNKRCIHQSNEP 253
C + C D TCC G CC A CC D++HCCP G +CDLV+ RCI +
Sbjct: 125 CPGSQFECPDSATCCIMIDGSWGCCPMPQASCCEDRVHCCPHGASCDLVHTRCISPTG-- 182
Query: 254 IEWPVVETIDSAKIETPKYTVERSTLREFMVKIGDKNNCPDGGQCAGLQTCCLMYTGHYG 433
P+++ + P R+ +V K CPD TCC + TG YG
Sbjct: 183 -THPLLK-------KFPAQRTNRAVASFSVVCPDAKTQCPDD------STCCELPTGKYG 228
Query: 434 CCPFSLGVCCPDLRTCCAPGYHC 502
CCP +CC D CC C
Sbjct: 229 CCPMPNAICCSDHLHCCPQDTVC 251
Score = 95.9 bits (237), Expect = 7e-20
Identities = 50/140 (35%), Positives = 64/140 (45%)
Frame = +2
Query: 95 CGDQKTCCASKSGGHQCCQYSNAVCCGDQLHCCPEGTTCDLVNKRCIHQSNEPIEWPVVE 274
C +TCC S G CCQ +AVCC D+ HCCP G TC++ + C
Sbjct: 447 CPVGQTCCPSLKGSWACCQLPHAVCCEDRQHCCPAGYTCNVKARTC-------------- 492
Query: 275 TIDSAKIETPKYTVERSTLREFMVKIGDKNNCPDGGQCAGLQTCCLMYTGHYGCCPFSLG 454
E +V+ S F K+G+ C G C Q+CC G + CCP+ G
Sbjct: 493 -------EKDAGSVQPSMDLTFGSKVGNV-ECGAGHFCHDNQSCCKDSQGGWACCPYVKG 544
Query: 455 VCCPDLRTCCAPGYHCVTGG 514
VCC D R CC G+HC G
Sbjct: 545 VCCRDGRHCCPIGFHCSAKG 564
Score = 90.9 bits (224), Expect = 2e-18
Identities = 43/140 (30%), Positives = 64/140 (45%)
Frame = +2
Query: 95 CGDQKTCCASKSGGHQCCQYSNAVCCGDQLHCCPEGTTCDLVNKRCIHQSNEPIEWPVVE 274
C D TCC +G CC ++ AVCC D +HCCP G C C ++ P ++
Sbjct: 287 CPDGYTCCRLNTGAWGCCPFTKAVCCEDHIHCCPAGFQCHTETGTC---ELGVLQVPWMK 343
Query: 275 TIDSAKIETPKYTVERSTLREFMVKIGDKNNCPDGGQCAGLQTCCLMYTGHYGCCPFSLG 454
+ +A + P + ++ + C D C TCC + +G +GCCP
Sbjct: 344 KV-TASLSLPDPQILKNDVP-----------CDDFSSCPSNNTCCRLSSGDWGCCPMPEA 391
Query: 455 VCCPDLRTCCAPGYHCVTGG 514
VCC D + CC G+ C+ G
Sbjct: 392 VCCLDHQHCCPQGFKCMDEG 411
Score = 78.2 bits (191), Expect = 2e-14
Identities = 44/136 (32%), Positives = 53/136 (38%)
Frame = +2
Query: 95 CGDQKTCCASKSGGHQCCQYSNAVCCGDQLHCCPEGTTCDLVNKRCIHQSNEPIEWPVVE 274
C TCC SG CC AVCC D HCCP+G C ++ +
Sbjct: 369 CPSNNTCCRLSSGDWGCCPMPEAVCCLDHQHCCPQGFKC--------------MDEGYCQ 414
Query: 275 TIDSAKIETPKYTVERSTLREFMVKIGDKNNCPDGGQCAGLQTCCLMYTGHYGCCPFSLG 454
D K V ++TL + GD C C QTCC G + CC
Sbjct: 415 KGDRMVAGLEKMPVRQTTLLQH----GDIG-CDQHTSCPVGQTCCPSLKGSWACCQLPHA 469
Query: 455 VCCPDLRTCCAPGYHC 502
VCC D + CC GY C
Sbjct: 470 VCCEDRQHCCPAGYTC 485
Score = 76.6 bits (187), Expect = 4e-14
Identities = 41/136 (30%), Positives = 51/136 (37%)
Frame = +2
Query: 95 CGDQKTCCASKSGGHQCCQYSNAVCCGDQLHCCPEGTTCDLVNKRCIHQSNEPIEWPVVE 274
C D +C + SG CC +S V C D HCCP G C K C S+ +
Sbjct: 67 CPDGYSCLLTVSGTSSCCPFSEGVSCDDGQHCCPRGFHCSADGKSCSQISDSLL------ 120
Query: 275 TIDSAKIETPKYTVERSTLREFMVKIGDKNNCPDGGQCAGLQTCCLMYTGHYGCCPFSLG 454
++ P G + CPD TCC+M G +GCCP
Sbjct: 121 ----GAVQCP----------------GSQFECPDSA------TCCIMIDGSWGCCPMPQA 154
Query: 455 VCCPDLRTCCAPGYHC 502
CC D CC G C
Sbjct: 155 SCCEDRVHCCPHGASC 170
Score = 60.1 bits (144), Expect = 4e-09
Identities = 25/86 (29%), Positives = 37/86 (43%), Gaps = 9/86 (10%)
Frame = +2
Query: 11 CNILQHVIAKTPGLLKENLNICQNGKA---------LCGDQKTCCASKSGGHQCCQYSNA 163
CN+ K G ++ ++++ K C D ++CC GG CC Y
Sbjct: 485 CNVKARTCEKDAGSVQPSMDLTFGSKVGNVECGAGHFCHDNQSCCKDSQGGWACCPYVKG 544
Query: 164 VCCGDQLHCCPEGTTCDLVNKRCIHQ 241
VCC D HCCP G C +C+ +
Sbjct: 545 VCCRDGRHCCPIGFHCSAKGTKCLRK 570
Score = 51.6 bits (122), Expect = 2e-06
Identities = 22/52 (42%), Positives = 29/52 (55%)
Frame = +2
Query: 359 KNNCPDGGQCAGLQTCCLMYTGHYGCCPFSLGVCCPDLRTCCAPGYHCVTGG 514
+++CPDG +C L +G CCPFS GV C D + CC G+HC G
Sbjct: 64 RDHCPDG------YSCLLTVSGTSSCCPFSEGVSCDDGQHCCPRGFHCSADG 109
>sp|P28797|GRN_CAVPO Granulins precursor (Proepithelin) (PEPI) [Contains: Acrogranin;
Granulin-1; Granulin-2; Granulin-3; Granulin-4;
Granulin-5; Granulin-6; Granulin-7]
Length = 591
Score = 115 bits (288), Expect = 9e-26
Identities = 58/159 (36%), Positives = 79/159 (49%), Gaps = 3/159 (1%)
Frame = +2
Query: 41 TPGLLKENLN---ICQNGKALCGDQKTCCASKSGGHQCCQYSNAVCCGDQLHCCPEGTTC 211
+PGLL L IC + ++ C D TCC SG + CC NA+CC D LHCCP+ T C
Sbjct: 194 SPGLLPAALPTSVICPDSRSQCPDDTTCCLLASGEYGCCPMPNAICCSDHLHCCPQDTVC 253
Query: 212 DLVNKRCIHQSNEPIEWPVVETIDSAKIETPKYTVERSTLREFMVKIGDKNNCPDGGQCA 391
DL RC+ Q+ + + P +TV + V+ + +CP+G
Sbjct: 254 DLRQSRCLSQNK----------AKTLLTKLPSWTV-------WDVECDQEVSCPEG---- 292
Query: 392 GLQTCCLMYTGHYGCCPFSLGVCCPDLRTCCAPGYHCVT 508
QTCC + +G +GCCPF VCC D CC + C T
Sbjct: 293 --QTCCRLQSGKWGCCPFPKAVCCEDHVHCCPERFRCHT 329
Score = 103 bits (257), Expect = 3e-22
Identities = 55/154 (35%), Positives = 72/154 (46%)
Frame = +2
Query: 53 LKENLNICQNGKALCGDQKTCCASKSGGHQCCQYSNAVCCGDQLHCCPEGTTCDLVNKRC 232
L + ++ + A C ++TCC GG CCQ +AVCC D HCCP G TC++ + C
Sbjct: 433 LSQTTDVGCDQHASCPVRQTCCPKLGGGWACCQLPHAVCCEDGQHCCPAGYTCNVKARSC 492
Query: 233 IHQSNEPIEWPVVETIDSAKIETPKYTVERSTLREFMVKIGDKNNCPDGGQCAGLQTCCL 412
+ D A + P ST V GD++ C D QTCC
Sbjct: 493 ------------EKAADGAHLAAP--LAVGSTGGVMDVACGDRHFCHDE------QTCCR 532
Query: 413 MYTGHYGCCPFSLGVCCPDLRTCCAPGYHCVTGG 514
G + CCPF GVCC D R CC G+HC + G
Sbjct: 533 DSRGGWACCPFHQGVCCKDQRHCCPAGFHCESQG 566
Score = 99.0 bits (245), Expect = 8e-21
Identities = 53/147 (36%), Positives = 67/147 (45%), Gaps = 4/147 (2%)
Frame = +2
Query: 74 CQNGKALCGDQKTCCASKSGGHQCCQYSNAVCCGDQLHCCPEGTTCDLVNKRCIHQ-SNE 250
C G+ C D TCC G CC A CC D++HCCP G +CDLV+ RC+ +
Sbjct: 112 CPGGEFECPDSSTCCHMLDGSWGCCPMPQASCCEDRVHCCPHGASCDLVHIRCVTALGSH 171
Query: 251 PI--EWPVVETIDSAKIETPKYTVERSTLREFMVKIGDKNNCPDG-GQCAGLQTCCLMYT 421
P+ + P T + TP V L + CPD QC TCCL+ +
Sbjct: 172 PLTTKLPAQRTNYTGAEGTP--VVSPGLL---PAALPTSVICPDSRSQCPDDTTCCLLAS 226
Query: 422 GHYGCCPFSLGVCCPDLRTCCAPGYHC 502
G YGCCP +CC D CC C
Sbjct: 227 GEYGCCPMPNAICCSDHLHCCPQDTVC 253
Score = 67.4 bits (163), Expect = 3e-11
Identities = 23/61 (37%), Positives = 34/61 (55%)
Frame = +2
Query: 65 LNICQNGKALCGDQKTCCASKSGGHQCCQYSNAVCCGDQLHCCPEGTTCDLVNKRCIHQS 244
+++ + C D++TCC GG CC + VCC DQ HCCP G C+ RC+H+
Sbjct: 514 MDVACGDRHFCHDEQTCCRDSRGGWACCPFHQGVCCKDQRHCCPAGFHCESQGTRCVHKK 573
Query: 245 N 247
+
Sbjct: 574 S 574
Score = 67.0 bits (162), Expect = 3e-11
Identities = 35/123 (28%), Positives = 50/123 (40%)
Frame = +2
Query: 95 CGDQKTCCASKSGGHQCCQYSNAVCCGDQLHCCPEGTTCDLVNKRCIHQSNEPIEWPVVE 274
C + +TCC +SG CC + AVCC D +HCCPE C C Q + W
Sbjct: 289 CPEGQTCCRLQSGKWGCCPFPKAVCCEDHVHCCPERFRCHTEKDTC-EQGLLQVPWAQKT 347
Query: 275 TIDSAKIETPKYTVERSTLREFMVKIGDKNNCPDGGQCAGLQTCCLMYTGHYGCCPFSLG 454
++ P + + +C + C CC + +G +GCCP S G
Sbjct: 348 PAQPSRPSQPSPPGPPGPPSP-PGPLRSEISCDEVVSCRPGNICCRLASGEWGCCPSSEG 406
Query: 455 VCC 463
C
Sbjct: 407 YLC 409
Score = 64.3 bits (155), Expect = 2e-10
Identities = 41/150 (27%), Positives = 55/150 (36%), Gaps = 1/150 (0%)
Frame = +2
Query: 74 CQNGKALCGDQKTCCASKSGGHQCCQYSNAVCCGDQLHCCPEGTTCDLVNKRCIHQSNEP 253
CQ+ A C +C + +G CC +S A+ CGD HCCP G C CI +
Sbjct: 47 CQS-PANCPIGHSCVLTAAGTAACCPFSQAMACGDGHHCCPYGFHCSTDGGTCIQR---- 101
Query: 254 IEWPVVETIDSAKIETPKYTVERSTLREFMVKIGDKNNCPDGG-QCAGLQTCCLMYTGHY 430
P + + + + CP G +C TCC M G +
Sbjct: 102 ---PDIHLLGAVQ-------------------------CPGGEFECPDSSTCCHMLDGSW 133
Query: 431 GCCPFSLGVCCPDLRTCCAPGYHCVTGGCA 520
GCCP CC D HC G +
Sbjct: 134 GCCPMPQASCCED-------RVHCCPHGAS 156
>sp|P28798|GRN_MOUSE Granulins precursor (Acrogranin) (Proepithelin) (PEPI) (PC
cell-derived growth factor) (PCDGF) [Contains: Granulin
1; Granulin 2; Granulin 3; Granulin 4; Granulin 5;
Granulin 6; Granulin 7]
Length = 589
Score = 114 bits (285), Expect = 2e-25
Identities = 54/146 (36%), Positives = 74/146 (50%)
Frame = +2
Query: 71 ICQNGKALCGDQKTCCASKSGGHQCCQYSNAVCCGDQLHCCPEGTTCDLVNKRCIHQSNE 250
+C + K C D TCC +G + CC NA+CC D LHCCP+ T CDL+ +C+ ++
Sbjct: 206 VCPDAKTQCPDDSTCCELPTGKYGCCPMPNAICCSDHLHCCPQDTVCDLIQSKCLSKN-- 263
Query: 251 PIEWPVVETIDSAKIETPKYTVERSTLREFMVKIGDKNNCPDGGQCAGLQTCCLMYTGHY 430
T D + P Y V+ VK + +CP+G TCC + TG +
Sbjct: 264 -------YTTD-LLTKLPGYPVKE-------VKCDMEVSCPEG------YTCCRLNTGAW 302
Query: 431 GCCPFSLGVCCPDLRTCCAPGYHCVT 508
GCCPF+ VCC D CC G+ C T
Sbjct: 303 GCCPFAKAVCCEDHIHCCPAGFQCHT 328
Score = 99.4 bits (246), Expect = 6e-21
Identities = 51/140 (36%), Positives = 68/140 (48%)
Frame = +2
Query: 95 CGDQKTCCASKSGGHQCCQYSNAVCCGDQLHCCPEGTTCDLVNKRCIHQSNEPIEWPVVE 274
C +TCC S G CCQ +AVCC D+ HCCP G TC++ + C + + I+ PV+
Sbjct: 448 CPVGQTCCPSLKGSWACCQLPHAVCCEDRQHCCPAGYTCNVKARTC-EKDVDFIQPPVLL 506
Query: 275 TIDSAKIETPKYTVERSTLREFMVKIGDKNNCPDGGQCAGLQTCCLMYTGHYGCCPFSLG 454
T+ K+G+ C +G C QTCC G + CCP+ G
Sbjct: 507 TLGP--------------------KVGNV-ECGEGHFCHDNQTCCKDSAGVWACCPYLKG 545
Query: 455 VCCPDLRTCCAPGYHCVTGG 514
VCC D R CC G+HC G
Sbjct: 546 VCCRDGRHCCPGGFHCSARG 565
Score = 97.4 bits (241), Expect = 2e-20
Identities = 49/144 (34%), Positives = 61/144 (42%), Gaps = 1/144 (0%)
Frame = +2
Query: 74 CQNGKALCGDQKTCCASKSGGHQCCQYSNAVCCGDQLHCCPEGTTCDLVNKRCIHQSNEP 253
C + C D TCC G CC A CC D++HCCP G +CDLV+ RC+ +
Sbjct: 125 CPGSQFECPDSATCCIMVDGSWGCCPMPQASCCEDRVHCCPHGASCDLVHTRCVSPTG-- 182
Query: 254 IEWPVVETIDSAKIETPKYTVERSTLREFMVKIGD-KNNCPDGGQCAGLQTCCLMYTGHY 430
+ + P R+ F V D K CPD TCC + TG Y
Sbjct: 183 --------THTLLKKFPAQKTNRAVSLPFSVVCPDAKTQCPDD------STCCELPTGKY 228
Query: 431 GCCPFSLGVCCPDLRTCCAPGYHC 502
GCCP +CC D CC C
Sbjct: 229 GCCPMPNAICCSDHLHCCPQDTVC 252
Score = 92.0 bits (227), Expect = 1e-18
Identities = 47/167 (28%), Positives = 71/167 (42%)
Frame = +2
Query: 14 NILQHVIAKTPGLLKENLNICQNGKALCGDQKTCCASKSGGHQCCQYSNAVCCGDQLHCC 193
N ++ K PG + + + + C + TCC +G CC ++ AVCC D +HCC
Sbjct: 263 NYTTDLLTKLPGYPVKEVKC--DMEVSCPEGYTCCRLNTGAWGCCPFAKAVCCEDHIHCC 320
Query: 194 PEGTTCDLVNKRCIHQSNEPIEWPVVETIDSAKIETPKYTVERSTLREFMVKIGDKNNCP 373
P G C H E +++ K+ P + L+ C
Sbjct: 321 PAGFQC--------HTEKGTCEMGILQVPWMKKVIAPLRLPDPQILKS-------DTPCD 365
Query: 374 DGGQCAGLQTCCLMYTGHYGCCPFSLGVCCPDLRTCCAPGYHCVTGG 514
D +C TCC + +G +GCCP VCC D + CC G+ C+ G
Sbjct: 366 DFTRCPTNNTCCKLNSGDWGCCPIPEAVCCSDNQHCCPQGFTCLAQG 412
Score = 83.2 bits (204), Expect = 5e-16
Identities = 42/136 (30%), Positives = 53/136 (38%)
Frame = +2
Query: 95 CGDQKTCCASKSGGHQCCQYSNAVCCGDQLHCCPEGTTCDLVNKRCIHQSNEPIEWPVVE 274
C +C + SG CC +S V CGD HCCP+G C K C S+ P+
Sbjct: 67 CPAGYSCLLTVSGTSSCCPFSKGVSCGDGYHCCPQGFHCSADGKSCFQMSDNPL------ 120
Query: 275 TIDSAKIETPKYTVERSTLREFMVKIGDKNNCPDGGQCAGLQTCCLMYTGHYGCCPFSLG 454
++ P G + CPD TCC+M G +GCCP
Sbjct: 121 ----GAVQCP----------------GSQFECPDSA------TCCIMVDGSWGCCPMPQA 154
Query: 455 VCCPDLRTCCAPGYHC 502
CC D CC G C
Sbjct: 155 SCCEDRVHCCPHGASC 170
Score = 82.4 bits (202), Expect = 8e-16
Identities = 47/137 (34%), Positives = 56/137 (40%), Gaps = 1/137 (0%)
Frame = +2
Query: 95 CGDQKTCCASKSGGHQCCQYSNAVCCGDQLHCCPEGTTCDLVNKRCIHQSNEPIEWPVVE 274
C TCC SG CC AVCC D HCCP+G TC L C
Sbjct: 370 CPTNNTCCKLNSGDWGCCPIPEAVCCSDNQHCCPQGFTC-LAQGYC-------------- 414
Query: 275 TIDSAKIETPKYTVERSTLREFM-VKIGDKNNCPDGGQCAGLQTCCLMYTGHYGCCPFSL 451
K +T +E+ R+ ++IGD C C QTCC G + CC
Sbjct: 415 ----QKGDTMVAGLEKIPARQTTPLQIGDIG-CDQHTSCPVGQTCCPSLKGSWACCQLPH 469
Query: 452 GVCCPDLRTCCAPGYHC 502
VCC D + CC GY C
Sbjct: 470 AVCCEDRQHCCPAGYTC 486
Score = 55.5 bits (132), Expect = 1e-07
Identities = 20/49 (40%), Positives = 25/49 (51%)
Frame = +2
Query: 95 CGDQKTCCASKSGGHQCCQYSNAVCCGDQLHCCPEGTTCDLVNKRCIHQ 241
C D +TCC +G CC Y VCC D HCCP G C +C+ +
Sbjct: 523 CHDNQTCCKDSAGVWACCPYLKGVCCRDGRHCCPGGFHCSARGTKCLRK 571
Score = 51.2 bits (121), Expect = 2e-06
Identities = 21/50 (42%), Positives = 25/50 (50%)
Frame = +2
Query: 365 NCPDGGQCAGLQTCCLMYTGHYGCCPFSLGVCCPDLRTCCAPGYHCVTGG 514
+C G C +C L +G CCPFS GV C D CC G+HC G
Sbjct: 60 SCQTHGHCPAGYSCLLTVSGTSSCCPFSKGVSCGDGYHCCPQGFHCSADG 109
>sp|P28799|GRN_HUMAN Granulins precursor (Proepithelin) (PEPI) [Contains: Acrogranin;
Paragranulin; Granulin-1 (Granulin G); Granulin-2
(Granulin F); Granulin-3 (Granulin B); Granulin-4
(Granulin A); Granulin-5 (Granulin C); Granulin-6
(Granulin D); Granulin-7 (Granulin E)]
Length = 593
Score = 113 bits (283), Expect = 3e-25
Identities = 53/146 (36%), Positives = 73/146 (50%)
Frame = +2
Query: 71 ICQNGKALCGDQKTCCASKSGGHQCCQYSNAVCCGDQLHCCPEGTTCDLVNKRCIHQSNE 250
+C + ++ C D TCC SG + CC NA CC D LHCCP+ T CDL+ +C+ + N
Sbjct: 207 MCPDARSRCPDGSTCCELPSGKYGCCPMPNATCCSDHLHCCPQDTVCDLIQSKCLSKENA 266
Query: 251 PIEWPVVETIDSAKIETPKYTVERSTLREFMVKIGDKNNCPDGGQCAGLQTCCLMYTGHY 430
+ + P +TV VK + +CPDG TCC + +G +
Sbjct: 267 TTD---------LLTKLPAHTVGD-------VKCDMEVSCPDG------YTCCRLQSGAW 304
Query: 431 GCCPFSLGVCCPDLRTCCAPGYHCVT 508
GCCPF+ VCC D CC G+ C T
Sbjct: 305 GCCPFTQAVCCEDHIHCCPAGFTCDT 330
Score = 101 bits (252), Expect = 1e-21
Identities = 56/176 (31%), Positives = 77/176 (43%)
Frame = +2
Query: 5 ALCNILQHVIAKTPGLLKENLNICQNGKALCGDQKTCCASKSGGHQCCQYSNAVCCGDQL 184
A ++L + A T G +K ++ + C D TCC +SG CC ++ AVCC D +
Sbjct: 266 ATTDLLTKLPAHTVGDVKCDMEVS------CPDGYTCCRLQSGAWGCCPFTQAVCCEDHI 319
Query: 185 HCCPEGTTCDLVNKRCIHQSNEPIEWPVVETIDSAKIETPKYTVERSTLREFMVKIGDKN 364
HCCP G TCD C P + P +E + ++R
Sbjct: 320 HCCPAGFTCDTQKGTC---EQGPHQVPWMEKAPAHLSLPDPQALKRDV------------ 364
Query: 365 NCPDGGQCAGLQTCCLMYTGHYGCCPFSLGVCCPDLRTCCAPGYHCVTGGCA*LGS 532
C + C TCC + +G +GCCP VCC D + CC GY CV G GS
Sbjct: 365 PCDNVSSCPSSDTCCQLTSGEWGCCPIPEAVCCSDHQHCCPQGYTCVAEGQCQRGS 420
Score = 95.5 bits (236), Expect = 9e-20
Identities = 51/144 (35%), Positives = 63/144 (43%), Gaps = 1/144 (0%)
Frame = +2
Query: 74 CQNGKALCGDQKTCCASKSGGHQCCQYSNAVCCGDQLHCCPEGTTCDLVNKRCIHQSNEP 253
C + + C D TCC G CC A CC D++HCCP G CDLV+ RCI +
Sbjct: 126 CPDSQFECPDFSTCCVMVDGSWGCCPMPQASCCEDRVHCCPHGAFCDLVHTRCITPTG-- 183
Query: 254 IEWPVVETIDSAKIETPKYTVERSTLREFMVKIGD-KNNCPDGGQCAGLQTCCLMYTGHY 430
T AK + P R+ V D ++ CPDG TCC + +G Y
Sbjct: 184 -------THPLAK-KLPAQRTNRAVALSSSVMCPDARSRCPDG------STCCELPSGKY 229
Query: 431 GCCPFSLGVCCPDLRTCCAPGYHC 502
GCCP CC D CC C
Sbjct: 230 GCCPMPNATCCSDHLHCCPQDTVC 253
Score = 94.0 bits (232), Expect = 3e-19
Identities = 47/141 (33%), Positives = 62/141 (43%), Gaps = 1/141 (0%)
Frame = +2
Query: 95 CGDQKTCCASKSGGHQCCQYSNAVCCGDQLHCCPEGTTCDLVNKRCIHQSNEPIEWPVVE 274
C +TCC S G CCQ +AVCC D+ HCCP G TC++ + C
Sbjct: 450 CPVGQTCCPSLGGSWACCQLPHAVCCEDRQHCCPAGYTCNVKARSC-------------- 495
Query: 275 TIDSAKIETPKYTVERSTLREFMVKIGDKN-NCPDGGQCAGLQTCCLMYTGHYGCCPFSL 451
E + + +T +G K+ C +G C QTCC + CCP+
Sbjct: 496 -------EKEVVSAQPATFLARSPHVGVKDVECGEGHFCHDNQTCCRDNRQGWACCPYRQ 548
Query: 452 GVCCPDLRTCCAPGYHCVTGG 514
GVCC D R CC G+ C G
Sbjct: 549 GVCCADRRHCCPAGFRCAARG 569
Score = 82.0 bits (201), Expect = 1e-15
Identities = 51/159 (32%), Positives = 65/159 (40%)
Frame = +2
Query: 26 HVIAKTPGLLKENLNICQNGKALCGDQKTCCASKSGGHQCCQYSNAVCCGDQLHCCPEGT 205
H+ P LK ++ C N + C TCC SG CC AVCC D HCCP+G
Sbjct: 351 HLSLPDPQALKRDVP-CDNVSS-CPSSDTCCQLTSGEWGCCPIPEAVCCSDHQHCCPQGY 408
Query: 206 TCDLVNKRCIHQSNEPIEWPVVETIDSAKIETPKYTVERSTLREFMVKIGDKNNCPDGGQ 385
TC + +C S I + + P S R+ + +CP G
Sbjct: 409 TC-VAEGQCQRGSE----------IVAGLEKMPARRASLSHPRD--IGCDQHTSCPVG-- 453
Query: 386 CAGLQTCCLMYTGHYGCCPFSLGVCCPDLRTCCAPGYHC 502
QTCC G + CC VCC D + CC GY C
Sbjct: 454 ----QTCCPSLGGSWACCQLPHAVCCEDRQHCCPAGYTC 488
Score = 77.8 bits (190), Expect = 2e-14
Identities = 44/159 (27%), Positives = 56/159 (35%), Gaps = 1/159 (0%)
Frame = +2
Query: 29 VIAKTPGLLKENLNICQNGKALCGDQKTCCASKSGGHQCCQYSNAVCCGDQLHCCPEGTT 208
++ K P L +L A C +C + SG CC + AV CGD HCCP G
Sbjct: 45 LLDKWPTTLSRHLGGPCQVDAHCSAGHSCIFTVSGTSSCCPFPEAVACGDGHHCCPRGFH 104
Query: 209 CDLVNKRCIHQSNEPIEWPVVETIDSAKIETPKYTVERSTLREFMVKIGDKNNCPDGG-Q 385
C + C +S + CPD +
Sbjct: 105 CSADGRSCFQRSGNNSVGAI--------------------------------QCPDSQFE 132
Query: 386 CAGLQTCCLMYTGHYGCCPFSLGVCCPDLRTCCAPGYHC 502
C TCC+M G +GCCP CC D CC G C
Sbjct: 133 CPDFSTCCVMVDGSWGCCPMPQASCCEDRVHCCPHGAFC 171
Score = 57.4 bits (137), Expect = 3e-08
Identities = 20/49 (40%), Positives = 25/49 (51%)
Frame = +2
Query: 95 CGDQKTCCASKSGGHQCCQYSNAVCCGDQLHCCPEGTTCDLVNKRCIHQ 241
C D +TCC G CC Y VCC D+ HCCP G C +C+ +
Sbjct: 527 CHDNQTCCRDNRQGWACCPYRQGVCCADRRHCCPAGFRCAARGTKCLRR 575
Score = 43.9 bits (102), Expect = 3e-04
Identities = 17/49 (34%), Positives = 21/49 (42%)
Frame = +2
Query: 368 CPDGGQCAGLQTCCLMYTGHYGCCPFSLGVCCPDLRTCCAPGYHCVTGG 514
C C+ +C +G CCPF V C D CC G+HC G
Sbjct: 61 CQVDAHCSAGHSCIFTVSGTSSCCPFPEAVACGDGHHCCPRGFHCSADG 109
>sp|P80059|PMD1_LOCMI Pars intercerebralis major peptide D1 (PMP-D1)
Length = 54
Score = 63.5 bits (153), Expect = 4e-10
Identities = 23/47 (48%), Positives = 28/47 (59%)
Frame = +2
Query: 95 CGDQKTCCASKSGGHQCCQYSNAVCCGDQLHCCPEGTTCDLVNKRCI 235
C +TCC + G CC Y VCC D +HCCP GT CD ++RCI
Sbjct: 7 CPGTETCCTTPQGEEGCCPYKEGVCCLDGIHCCPSGTVCDEDHRRCI 53
Score = 48.9 bits (115), Expect = 1e-05
Identities = 19/39 (48%), Positives = 21/39 (53%)
Frame = +2
Query: 386 CAGLQTCCLMYTGHYGCCPFSLGVCCPDLRTCCAPGYHC 502
C G +TCC G GCCP+ GVCC D CC G C
Sbjct: 7 CPGTETCCTTPQGEEGCCPYKEGVCCLDGIHCCPSGTVC 45
>sp|P80930|ENA1_HORSE Antimicrobial peptide eNAP-1
Length = 46
Score = 59.3 bits (142), Expect = 7e-09
Identities = 21/36 (58%), Positives = 23/36 (63%)
Frame = +2
Query: 95 CGDQKTCCASKSGGHQCCQYSNAVCCGDQLHCCPEG 202
C D +TCC + GG CC YS VCC DQ HCCP G
Sbjct: 10 CHDXQTCCRASQGGXACCPYSQGVCCADQRHCCPVG 45
Score = 53.9 bits (128), Expect = 3e-07
Identities = 21/43 (48%), Positives = 24/43 (55%)
Frame = +2
Query: 368 CPDGGQCAGLQTCCLMYTGHYGCCPFSLGVCCPDLRTCCAPGY 496
C +G C QTCC G CCP+S GVCC D R CC G+
Sbjct: 4 CGEGHFCHDXQTCCRASQGGXACCPYSQGVCCADQRHCCPVGF 46
>sp|P81013|GRN1_CYPCA Granulin-1
Length = 57
Score = 55.5 bits (132), Expect = 1e-07
Identities = 24/45 (53%), Positives = 26/45 (57%)
Frame = +2
Query: 368 CPDGGQCAGLQTCCLMYTGHYGCCPFSLGVCCPDLRTCCAPGYHC 502
CPDG TCCL G + CCPFS+G CC D CC GYHC
Sbjct: 10 CPDG------TTCCLSPYGVWYCCPFSMGQCCRDGIHCCRHGYHC 48
Score = 53.5 bits (127), Expect = 4e-07
Identities = 20/48 (41%), Positives = 25/48 (52%)
Frame = +2
Query: 92 LCGDQKTCCASKSGGHQCCQYSNAVCCGDQLHCCPEGTTCDLVNKRCI 235
+C D TCC S G CC +S CC D +HCC G CD + C+
Sbjct: 9 ICPDGTTCCLSPYGVWYCCPFSMGQCCRDGIHCCRHGYHCDSTSTHCL 56
>sp|P81015|GRN3_CYPCA Granulin-3
Length = 57
Score = 53.9 bits (128), Expect = 3e-07
Identities = 22/45 (48%), Positives = 24/45 (53%)
Frame = +2
Query: 368 CPDGGQCAGLQTCCLMYTGHYGCCPFSLGVCCPDLRTCCAPGYHC 502
C G C TCC G + CCPF +G CC D R CC GYHC
Sbjct: 4 CDAGITCPSGTTCCRSPFGVWYCCPFLMGQCCRDGRHCCRHGYHC 48
Score = 45.8 bits (107), Expect = 8e-05
Identities = 18/47 (38%), Positives = 21/47 (44%)
Frame = +2
Query: 95 CGDQKTCCASKSGGHQCCQYSNAVCCGDQLHCCPEGTTCDLVNKRCI 235
C TCC S G CC + CC D HCC G CD + C+
Sbjct: 10 CPSGTTCCRSPFGVWYCCPFLMGQCCRDGRHCCRHGYHCDSTSTLCL 56
>sp|P81014|GRN2_CYPCA Granulin-2
Length = 57
Score = 50.1 bits (118), Expect = 4e-06
Identities = 19/52 (36%), Positives = 24/52 (46%)
Frame = +2
Query: 80 NGKALCGDQKTCCASKSGGHQCCQYSNAVCCGDQLHCCPEGTTCDLVNKRCI 235
N + C + TCC S G CC + CC D HCC G CD + C+
Sbjct: 5 NARTTCPSRTTCCRSPFGVWYCCPFLMGQCCRDGRHCCRHGYRCDSTSTLCL 56
Score = 48.9 bits (115), Expect = 1e-05
Identities = 19/39 (48%), Positives = 21/39 (53%)
Frame = +2
Query: 386 CAGLQTCCLMYTGHYGCCPFSLGVCCPDLRTCCAPGYHC 502
C TCC G + CCPF +G CC D R CC GY C
Sbjct: 10 CPSRTTCCRSPFGVWYCCPFLMGQCCRDGRHCCRHGYRC 48
>sp|O42182|FBLN1_BRARE Fibulin-1 precursor
Length = 681
Score = 43.9 bits (102), Expect = 3e-04
Identities = 49/181 (27%), Positives = 66/181 (36%), Gaps = 18/181 (9%)
Frame = +2
Query: 68 NICQNGKALCGDQKTCCASKSGGHQCCQYSNAVCCGDQLHCCPEGTTCDLVNKRC---IH 238
+IC +G + DQ +C A SG C + +CC CC G++ RC +
Sbjct: 70 SICTSGINMAKDQSSCDALLSGSSTCETKTTKMCC----ECCLLGSS------RCRIRVS 119
Query: 239 QSNEPIEWPVVETIDSAKIETPKYTVERSTLREFMVKIGDKNNCPDGGQCAGLQTCCLMY 418
+ W + S V++ GD N D + AG CL
Sbjct: 120 PVSSVCRWSI-----SRGPGVRSCCVDKQPAHGVQPSKGDAQNTEDQCRAAGCAQRCL-- 172
Query: 419 TGHYGCCP-FSL---GVCCPDLRTCCAPGYHCVTGG--CA*LGSYE---------GYFIT 553
G C F L G C D+ C +HCVTG LGSY GY +T
Sbjct: 173 NGTCSCLDGFKLKTDGKHCEDINECLLGPHHCVTGERCINTLGSYRCQREISCGTGYELT 232
Query: 554 D 556
D
Sbjct: 233 D 233
Score = 29.6 bits (65), Expect = 6.2
Identities = 44/192 (22%), Positives = 63/192 (32%), Gaps = 17/192 (8%)
Frame = +2
Query: 11 CNILQHVIAKTPGLLKENLNICQNGKALCGDQKTCCASKSGGHQCCQYSNAVCCGDQLHC 190
C+ L KT G E++N C G C + C + G ++C + CG
Sbjct: 176 CSCLDGFKLKTDGKHCEDINECLLGPHHCVTGERCI-NTLGSYRC---QREISCGTGYEL 231
Query: 191 -----CPEGTTCDLVNKRCIHQSNEPIEWPVVETIDSAKIETPKYTVERSTLREFMVKIG 355
C + CDL C E T S + P+ +++ +
Sbjct: 232 TDNNKCKDIDECDLGTHNCA------AEMECQNTAGSFRCR-PRMQCAAGFIQDALGSCI 284
Query: 356 DKNNCPDGGQCAGLQTCCLMYTGHYGCCPFSL-----------GVCCPDLRTCCAPGYHC 502
D N C + Q C G + C S+ G C D+ C P C
Sbjct: 285 DINECVSVTALSRGQMC-FNTVGSFICQRHSVTCGRGYHLNAEGTRCVDIDECAGPDNSC 343
Query: 503 VTGGCA*L-GSY 535
GC L GSY
Sbjct: 344 DGHGCINLVGSY 355
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 74,351,794
Number of Sequences: 369166
Number of extensions: 1677725
Number of successful extensions: 5801
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 4945
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 5653
length of database: 68,354,980
effective HSP length: 105
effective length of database: 48,957,805
effective search space used: 4650991475
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)