Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_025_D21
(616 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P60891|PRPS1_HUMAN Ribose-phosphate pyrophosphokinase I ... 135 6e-32
sp|Q9D7G0|PRPS1_MOUSE Ribose-phosphate pyrophosphokinase I ... 135 8e-32
sp|Q4R4R7|PRPS2_MACFA Ribose-phosphate pyrophosphokinase II... 133 4e-31
sp|P09330|PRPS2_RAT Ribose-phosphate pyrophosphokinase II (... 133 4e-31
sp|Q9CS42|PRPS2_MOUSE Ribose-phosphate pyrophosphokinase II... 132 5e-31
sp|P21108|PRPS3_HUMAN Ribose-phosphate pyrophosphokinase II... 129 6e-30
sp|P38689|KPR3_YEAST Ribose-phosphate pyrophosphokinase 3 (... 115 7e-26
sp|O60256|KPRB_HUMAN Phosphoribosyl pyrophosphate synthetas... 107 3e-23
sp|Q8R574|KPRB_MOUSE Phosphoribosyl pyrophosphate synthetas... 105 9e-23
sp|O08618|KPRB_RAT Phosphoribosyl pyrophosphate synthetase-... 105 9e-23
>sp|P60891|PRPS1_HUMAN Ribose-phosphate pyrophosphokinase I (Phosphoribosyl pyrophosphate
synthetase I) (PRS-I) (PPRibP)
sp|P60892|PRPS1_RAT Ribose-phosphate pyrophosphokinase I (Phosphoribosyl pyrophosphate
synthetase I) (PRS-I)
Length = 318
Score = 135 bits (341), Expect = 6e-32
Identities = 69/165 (41%), Positives = 108/165 (65%), Gaps = 2/165 (1%)
Frame = +1
Query: 4 ISWIKKNISKWEEITIFSLNVTSAERVANMANTLKVRFGLIYVEKKEASE--QIILVGDV 177
+ WI++NIS+W TI S + A+RV ++A+ L V F LI+ E+K+A+E +++LVGDV
Sbjct: 152 LKWIRENISEWRNCTIVSPDAGGAKRVTSIADRLNVDFALIHKERKKANEVDRMVLVGDV 211
Query: 178 VSRIAVILLDIIDNCDLVISSVKRLKEVGAAGVYVIATHGMLSERLMKEVDDSIITKLVV 357
R+A+++ D+ D C + + +L GA VY I THG+ S + ++++ +VV
Sbjct: 212 KDRVAILVDDMADTCGTICHAADKLLSAGATRVYAILTHGIFSGPAISRINNACFEAVVV 271
Query: 358 TNTICQEKYVKQSDKIACLDVSVIFAEAIRRIHYGESVSCLYNNL 492
TNTI QE +K KI +D+S+I AEAIRR H GESVS L++++
Sbjct: 272 TNTIPQEDKMKHCSKIQVIDISMILAEAIRRTHNGESVSYLFSHV 316
>sp|Q9D7G0|PRPS1_MOUSE Ribose-phosphate pyrophosphokinase I (Phosphoribosyl pyrophosphate
synthetase I) (PRS-I)
Length = 318
Score = 135 bits (340), Expect = 8e-32
Identities = 69/165 (41%), Positives = 107/165 (64%), Gaps = 2/165 (1%)
Frame = +1
Query: 4 ISWIKKNISKWEEITIFSLNVTSAERVANMANTLKVRFGLIYVEKKEASE--QIILVGDV 177
+ WI++NIS+W TI S + A+RV ++A L V F LI+ E+K+A+E +++LVGDV
Sbjct: 152 LKWIRENISEWRNCTIVSPDAGGAKRVTSIAERLNVDFALIHKERKKANEVDRMVLVGDV 211
Query: 178 VSRIAVILLDIIDNCDLVISSVKRLKEVGAAGVYVIATHGMLSERLMKEVDDSIITKLVV 357
R+A+++ D+ D C + + +L GA VY I THG+ S + ++++ +VV
Sbjct: 212 KDRVAILVDDMADTCGTICHAADKLLSAGATRVYAILTHGIFSGPAISRINNACFEAVVV 271
Query: 358 TNTICQEKYVKQSDKIACLDVSVIFAEAIRRIHYGESVSCLYNNL 492
TNTI QE +K KI +D+S+I AEAIRR H GESVS L++++
Sbjct: 272 TNTIPQEDKMKHCSKIQVIDISMILAEAIRRTHNGESVSYLFSHV 316
>sp|Q4R4R7|PRPS2_MACFA Ribose-phosphate pyrophosphokinase II (Phosphoribosyl pyrophosphate
synthetase II) (PRS-II)
sp|P11908|PRPS2_HUMAN Ribose-phosphate pyrophosphokinase II (Phosphoribosyl pyrophosphate
synthetase II) (PRS-II) (PPRibP)
Length = 318
Score = 133 bits (334), Expect = 4e-31
Identities = 67/165 (40%), Positives = 108/165 (65%), Gaps = 2/165 (1%)
Frame = +1
Query: 4 ISWIKKNISKWEEITIFSLNVTSAERVANMANTLKVRFGLIYVEKKEASE--QIILVGDV 177
+ WI++NI++W+ I S + A+RV ++A+ L V F LI+ E+K+A+E +++LVGDV
Sbjct: 152 LQWIRENIAEWKNCIIVSPDAGGAKRVTSIADRLNVEFALIHKERKKANEVDRMVLVGDV 211
Query: 178 VSRIAVILLDIIDNCDLVISSVKRLKEVGAAGVYVIATHGMLSERLMKEVDDSIITKLVV 357
R+A+++ D+ D C + + +L GA VY I THG+ S + ++++ +VV
Sbjct: 212 KDRVAILVDDMADTCGTICHAADKLLSAGATKVYAILTHGIFSGPAISRINNAAFEAVVV 271
Query: 358 TNTICQEKYVKQSDKIACLDVSVIFAEAIRRIHYGESVSCLYNNL 492
TNTI QE +K KI +D+S+I AEAIRR H GESVS L++++
Sbjct: 272 TNTIPQEDKMKHCTKIQVIDISMILAEAIRRTHNGESVSYLFSHV 316
>sp|P09330|PRPS2_RAT Ribose-phosphate pyrophosphokinase II (Phosphoribosyl pyrophosphate
synthetase II) (PRS-II)
Length = 318
Score = 133 bits (334), Expect = 4e-31
Identities = 67/165 (40%), Positives = 107/165 (64%), Gaps = 2/165 (1%)
Frame = +1
Query: 4 ISWIKKNISKWEEITIFSLNVTSAERVANMANTLKVRFGLIYVEKKEASE--QIILVGDV 177
+ WI++NI++W I S + A+RV ++A+ L V F LI+ E+K+A+E +++LVGDV
Sbjct: 152 LQWIRENITEWRNCIIVSPDAGGAKRVTSIADRLNVEFALIHKERKKANEVDRMVLVGDV 211
Query: 178 VSRIAVILLDIIDNCDLVISSVKRLKEVGAAGVYVIATHGMLSERLMKEVDDSIITKLVV 357
R+A+++ D+ D C + + +L GA VY I THG+ S + ++++ +VV
Sbjct: 212 KDRVAILVDDMADTCGTICHAADKLLSAGATKVYAILTHGIFSGPAISRINNAAFEAVVV 271
Query: 358 TNTICQEKYVKQSDKIACLDVSVIFAEAIRRIHYGESVSCLYNNL 492
TNTI QE +K KI +D+S+I AEAIRR H GESVS L++++
Sbjct: 272 TNTIPQEDKMKHCSKIQVIDISMILAEAIRRTHNGESVSYLFSHV 316
>sp|Q9CS42|PRPS2_MOUSE Ribose-phosphate pyrophosphokinase II (Phosphoribosyl pyrophosphate
synthetase II) (PRS-II)
Length = 318
Score = 132 bits (333), Expect = 5e-31
Identities = 67/165 (40%), Positives = 106/165 (64%), Gaps = 2/165 (1%)
Frame = +1
Query: 4 ISWIKKNISKWEEITIFSLNVTSAERVANMANTLKVRFGLIYVEKKEASE--QIILVGDV 177
+ WI++NI++W I S + A+RV ++A+ L V F LI+ E+K+A+E +++LVGDV
Sbjct: 152 LQWIRENITEWRNCIIVSPDAGGAKRVTSIADRLNVEFALIHKERKKANEVDRMVLVGDV 211
Query: 178 VSRIAVILLDIIDNCDLVISSVKRLKEVGAAGVYVIATHGMLSERLMKEVDDSIITKLVV 357
R+A+++ D+ D C + + +L GA VY I THG+ S + ++ + +VV
Sbjct: 212 KDRVAILVDDMADTCGTICHAADKLLSAGATKVYAILTHGIFSGPAISRINSAAFEAVVV 271
Query: 358 TNTICQEKYVKQSDKIACLDVSVIFAEAIRRIHYGESVSCLYNNL 492
TNTI QE +K KI +D+S+I AEAIRR H GESVS L++++
Sbjct: 272 TNTIPQEDKMKHCSKIQVIDISMILAEAIRRTHNGESVSYLFSHV 316
>sp|P21108|PRPS3_HUMAN Ribose-phosphate pyrophosphokinase III (Phosphoribosyl
pyrophosphate synthetase III) (PRS-III) (Phosphoribosyl
pyrophosphate synthetase 1-like 1)
Length = 318
Score = 129 bits (324), Expect = 6e-30
Identities = 67/165 (40%), Positives = 106/165 (64%), Gaps = 2/165 (1%)
Frame = +1
Query: 4 ISWIKKNISKWEEITIFSLNVTSAERVANMANTLKVRFGLIYVEKKEASEQ--IILVGDV 177
+ WI++NI +W+ I S + A+RV ++A+ L V F LI+ E+K+A+E I+LVGDV
Sbjct: 152 LKWIRENIPEWKNCIIVSPDAGGAKRVTSIADQLNVDFALIHKERKKANEVDCIVLVGDV 211
Query: 178 VSRIAVILLDIIDNCDLVISSVKRLKEVGAAGVYVIATHGMLSERLMKEVDDSIITKLVV 357
R+A+++ D+ D C + + +L GA VY I THG+ S + ++ + +VV
Sbjct: 212 NDRVAILVDDMADTCVTICLAADKLLSAGATRVYAILTHGIFSGPAISRINTACFEAVVV 271
Query: 358 TNTICQEKYVKQSDKIACLDVSVIFAEAIRRIHYGESVSCLYNNL 492
TNTI Q++ +K KI +D+S+I AEAIRR H GESVS L++++
Sbjct: 272 TNTIPQDEKMKHCSKIRVIDISMILAEAIRRTHNGESVSYLFSHV 316
>sp|P38689|KPR3_YEAST Ribose-phosphate pyrophosphokinase 3 (Phosphoribosyl pyrophosphate
synthetase 3)
Length = 320
Score = 115 bits (289), Expect = 7e-26
Identities = 61/164 (37%), Positives = 106/164 (64%), Gaps = 2/164 (1%)
Frame = +1
Query: 4 ISWIKKNISKWEEITIFSLNVTSAERVANMANTLKVRFGLIYVEKKEASE--QIILVGDV 177
+ +IK+N++ + I I S + A+R A +A+ L + F LI+ E+ A+E +++LVGDV
Sbjct: 155 VRYIKENVNYMDSI-IISPDAGGAKRAATLADRLDLNFALIHKERARANEVSRMVLVGDV 213
Query: 178 VSRIAVILLDIIDNCDLVISSVKRLKEVGAAGVYVIATHGMLSERLMKEVDDSIITKLVV 357
+I +I+ D+ D C + + + L E A V I THG+LS R ++ +++S + ++V
Sbjct: 214 TDKICIIVDDMADTCGTLAKAAEILLENRAKSVIAIVTHGVLSGRAIENINNSKLDRVVC 273
Query: 358 TNTICQEKYVKQSDKIACLDVSVIFAEAIRRIHYGESVSCLYNN 489
TNT+ E+ +K+ K+A +D+S + AE+IRR+H GES+S L+ N
Sbjct: 274 TNTVPFEEKIKKCPKLAVIDISSVLAESIRRLHNGESISYLFKN 317
>sp|O60256|KPRB_HUMAN Phosphoribosyl pyrophosphate synthetase-associated protein 2 (PRPP
synthetase-associated protein 2) (41 kDa
phosphoribosypyrophosphate synthetase-associated
protein) (PAP41)
Length = 369
Score = 107 bits (266), Expect = 3e-23
Identities = 64/196 (32%), Positives = 106/196 (54%), Gaps = 33/196 (16%)
Frame = +1
Query: 4 ISWIKKNISKWEEITIFSLNVTSAERVANMANTLKVRFGLIYVEKKEASEQII------- 162
+ +I++ I + I + + SA+R + A L++ +I+ E ++A ++
Sbjct: 170 LQYIQEEIPDYRNAVIVAKSPASAKRAQSFAERLRLGIAVIHGEAQDAESDLVDGRHSPP 229
Query: 163 --------------------------LVGDVVSRIAVILLDIIDNCDLVISSVKRLKEVG 264
+VGDV RIA+I+ DIID+ D +++ + LKE G
Sbjct: 230 MVRSVAAIHPSLEIPMLIPKEKPPITVVGDVGGRIAIIVDDIIDDVDSFLAAAETLKERG 289
Query: 265 AAGVYVIATHGMLSERLMKEVDDSIITKLVVTNTICQEKYVKQSDKIACLDVSVIFAEAI 444
A ++V+ATHG+LS + +++S I ++VVTNTI E Q KI +D+S+I +EAI
Sbjct: 290 AYKIFVMATHGLLSSDAPRRIEESAIDEVVVTNTIPHEVQKLQCPKIKTVDISMILSEAI 349
Query: 445 RRIHYGESVSCLYNNL 492
RRIH GES+S L+ N+
Sbjct: 350 RRIHNGESMSYLFRNI 365
>sp|Q8R574|KPRB_MOUSE Phosphoribosyl pyrophosphate synthetase-associated protein 2 (PRPP
synthetase-associated protein 2) (41 kDa
phosphoribosypyrophosphate synthetase-associated
protein) (PAP41)
Length = 369
Score = 105 bits (262), Expect = 9e-23
Identities = 64/196 (32%), Positives = 106/196 (54%), Gaps = 33/196 (16%)
Frame = +1
Query: 4 ISWIKKNISKWEEITIFSLNVTSAERVANMANTLKVRFGLIYVEKKEASEQII------- 162
+ +I++ I + I + + SA+R + A L++ +I+ E ++A ++
Sbjct: 170 LQYIQEEIPDYRNAVIVAKSPASAKRAQSFAERLRLGIAVIHGEAQDAESDLVDGRHSPP 229
Query: 163 --------------------------LVGDVVSRIAVILLDIIDNCDLVISSVKRLKEVG 264
+VGDV RIA+I+ DIID+ D +++ + LKE G
Sbjct: 230 MVRSVAAIHPSLEIPMLIPKEKPPITVVGDVGGRIAIIVDDIIDDVDSFLAAAETLKERG 289
Query: 265 AAGVYVIATHGMLSERLMKEVDDSIITKLVVTNTICQEKYVKQSDKIACLDVSVIFAEAI 444
A ++V+ATHG+LS + +++S I ++VVTNTI E Q KI +D+S+I +EAI
Sbjct: 290 AYKIFVMATHGLLSSDAPRLIEESAIDEVVVTNTIPHEIQKLQCPKIKTVDISMILSEAI 349
Query: 445 RRIHYGESVSCLYNNL 492
RRIH GES+S L+ N+
Sbjct: 350 RRIHNGESMSYLFRNI 365
>sp|O08618|KPRB_RAT Phosphoribosyl pyrophosphate synthetase-associated protein 2 (PRPP
synthetase-associated protein 2) (41 kDa
phosphoribosypyrophosphate synthetase-associated
protein) (PAP41)
Length = 369
Score = 105 bits (262), Expect = 9e-23
Identities = 64/196 (32%), Positives = 106/196 (54%), Gaps = 33/196 (16%)
Frame = +1
Query: 4 ISWIKKNISKWEEITIFSLNVTSAERVANMANTLKVRFGLIYVEKKEASEQII------- 162
+ +I++ I + I + + SA+R + A L++ +I+ E ++A ++
Sbjct: 170 LQYIQEEIPDYRNAVIVAKSPASAKRAQSFAERLRLGIAVIHGEAQDAESDLVDGRHSPP 229
Query: 163 --------------------------LVGDVVSRIAVILLDIIDNCDLVISSVKRLKEVG 264
+VGDV RIA+I+ DIID+ D +++ + LKE G
Sbjct: 230 MVRSVAAIHPSLEIPMLIPKEKPPITVVGDVGGRIAIIVDDIIDDVDSFLAAAETLKERG 289
Query: 265 AAGVYVIATHGMLSERLMKEVDDSIITKLVVTNTICQEKYVKQSDKIACLDVSVIFAEAI 444
A ++V+ATHG+LS + +++S I ++VVTNTI E Q KI +D+S+I +EAI
Sbjct: 290 AYKIFVMATHGLLSSDAPRLIEESAIDEVVVTNTIPHEIQKLQCPKIKTVDISMILSEAI 349
Query: 445 RRIHYGESVSCLYNNL 492
RRIH GES+S L+ N+
Sbjct: 350 RRIHNGESMSYLFRNI 365
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 66,856,968
Number of Sequences: 369166
Number of extensions: 1253679
Number of successful extensions: 3655
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 3404
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 3600
length of database: 68,354,980
effective HSP length: 105
effective length of database: 48,957,805
effective search space used: 4846822695
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)